keyword
MENU ▼
Read by QxMD icon Read
search

Vegfr3

keyword
https://www.readbyqxmd.com/read/27901498/targeting-the-vegf-c-vegfr3-axis-suppresses-slug-mediated-cancer-metastasis-and-stemness-via-inhibition-of-kras-yap1-signaling
#1
REVIEW
Yu-Wen Yeh, Ching-Chia Cheng, Shu-Ting Yang, Chi-Feng Tseng, Ting-Yu Chang, Sin-Ying Tsai, Earl Fu, Chien-Ping Chiang, Li-Chuan Liao, Pei-Wen Tsai, Yung-Luen Yu, Jen-Liang Su
Vascular endothelial growth factor-C (VEGF-C) has been implicated in epithelial-mesenchymal transition (EMT) processes and various human cancers, including skin cancer. Skin cancer is an aggressive human malignancy with increasing incidence worldwide; however, the underlying mechanisms involved in VEGF-C-induced skin cancer stemness and metastasis remain unclear. Here, we report that VEGF-C enhances skin cancer migration, invasion and stemness through Slug up-regulation. Oncomine database analysis indicated that the KRAS/MAPK (mitogen-activated protein kinases) pathway and YAP1 (yes-associated protein 1) expression are positively correlated with metastatic skin cancer...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27896475/an-exploratory-association-of-polymorphisms-in-angiogenesis-related-genes-with-susceptibility-clinical-response-and-toxicity-in-gastrointestinal-stromal-tumors-receiving-sunitinib-after-imatinib-failure
#2
Gloria Ravegnini, Margherita Nannini, Corrado Zenesini, Vittorio Simeon, Giulia Sammarini, Milena Urbini, Lidia Gatto, Maristella Saponara, Guido Biasco, Maria A Pantaleo, Nicola Venturoli, Patrizia Hrelia, Sabrina Angelini
The angiogenic pathway plays a pivotal role in tumor growth, invasiveness and metastasis. The most important actors in the angiogenic pathway are VEGFA and its receptors VEGFR1, 2 and 3. These genes are polymorphic, and the presence of single nucleotide polymorphisms may result in angiogenic deregulation. Herein, we hypothesized that germline variants may affect sunitinib efficacy (TTP and OS) and/or toxicity. Therefore, we investigated 19 polymorphisms, in four genes, in 54 GIST patients, treated with second-line sunitinib and 147 healthy controls...
November 28, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27861873/notch-signaling-pathway-regulates-angiogenesis-via-endothelial-cell-in-3d-co-culture-model
#3
Dan Zhao, Changyue Xue, Shiyu Lin, Sirong Shi, Qianshun Li, Mengting Liu, Xiaoxiao Cai, Yunfeng Lin
This study aimed to investigate the role of Notch signaling pathway for angiogenesis in a three-dimensional (3D) collagen gel model with co-culture of adipose-derived stromal cells (ASCs) and endothelial cells (ECs). A 3D collagen gel model was established in vitro by implanting both ASCs from green fluorescent protein-labeled mouse and ECs from red fluorescent protein-labeled mouse, and the phenomena of angiogenesis with Notch signaling inducer Jagged1, inhibitor DAPT and PBS, respectively were observed by confocal laser scanning microscopy...
November 10, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27787629/lymphangiogenesis-in-rat-asthma-model
#4
Aigul Moldobaeva, John Jenkins, Qiong Zhong, Elizabeth M Wagner
Although bronchial angiogenesis has been well documented in allergic asthma, lymphangiogenesis has not been widely studied. Therefore, we evaluated changes in lung lymphatics in a rat model of allergen-induced asthma using house dust mite (Der p 1; 100 μg/challenge). Additionally, properties of isolated lung lymphatic endothelial cells (CD45(-), CD141(+), LYVE-1(+), Prox-1(+)) were studied in vitro. Three weeks after the onset of intranasal allergen exposure (twice-weekly), an increase in the number of lung lymphatic vessels was measured (34% increase) by lung morphometry...
October 27, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27783948/macrophage-induced-lymphangiogenesis-and-metastasis-following-paclitaxel-chemotherapy-is-regulated-by-vegfr3
#5
Dror Alishekevitz, Svetlana Gingis-Velitski, Orit Kaidar-Person, Lilach Gutter-Kapon, Sandra D Scherer, Ziv Raviv, Emmanuelle Merquiol, Yael Ben-Nun, Valeria Miller, Chen Rachman-Tzemah, Michael Timaner, Yelena Mumblat, Neta Ilan, David Loven, Dov Hershkovitz, Ronit Satchi-Fainaro, Galia Blum, Jonathan P Sleeman, Israel Vlodavsky, Yuval Shaked
While chemotherapy strongly restricts or reverses tumor growth, the response of host tissue to therapy can counteract its anti-tumor activity by promoting tumor re-growth and/or metastases, thus limiting therapeutic efficacy. Here, we show that vascular endothelial growth factor receptor 3 (VEGFR3)-expressing macrophages infiltrating chemotherapy-treated tumors play a significant role in metastasis. They do so in part by inducing lymphangiogenesis as a result of cathepsin release, leading to VEGF-C upregulation by heparanase...
October 25, 2016: Cell Reports
https://www.readbyqxmd.com/read/27781955/mmp14-regulates-vegfr3-expression-on-corneal-epithelial-cells
#6
Robert Jin-Hong Chang, Dimitri T Azar, Kyu-Yeon Han
Vascular endothelial growth factor receptor 3 (VEGFR3) regulates the growth and differentiation of blood and lymphatic vessels. To determine whether matrix metalloproteinase 14 (MMP14) modulates VEGFR3 expression in the corneal epithelium to influence the avascularity of the cornea, VEGFR3 expression was compared between wild-type and MMP14-deficient (MMP14 Δexon4) corneal epithelial cells. Western blot analysis showed that VEGFR3 protein expression was higher on MMP14 Δexon4 corneal epithelial cells than on wild-type cells, and quantitative RT-PCR analysis showed that VEGFR3 gene expression was highly induced in MMP14 Δexon4 corneal epithelial cells but not in wild-type corneal epithelial cells or wild-type and MMP14 Δexon4 corneal keratocytes...
October 24, 2016: Protein and Peptide Letters
https://www.readbyqxmd.com/read/27668980/vegf-a-and-vegfr1-snps-associate-with-preeclampsia-in-a-philippine-population
#7
Melissa D Amosco, Van Anthony M Villar, Justin Michael A Naniong, Lara Marie G David-Bustamante, Pedro A Jose, Cynthia P Palmes-Saloma
The vascular endothelial growth factor (VEGF) family is important for establishing normal pregnancy, and related single nucleotide polymorphisms (SNPs) are implicated in abnormal placentation and preeclampsia. We evaluated the association between preeclampsia and several VEGF SNPs among Filipinos, an ethnically distinct group with high prevalence of preeclampsia. The genotypes and allelic variants were determined in a case-control study (191 controls and 165 preeclampsia patients) through SNP analysis of VEGF-A (rs2010963, rs3025039) and VEGF-C (rs7664413) and their corresponding receptors VEGFR1 (rs722503, rs12584067, rs7335588) and VEGFR3 (rs307826) from venous blood DNA...
2016: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/27623309/coordinated-lymphangiogenesis-is-critical-in-lymph-node-development-and-maturation
#8
Yulia Ga-Eun Lee, Gou Young Koh
BACKGROUND: Lymph node (LN) formation requires multiple but coordinated signaling from intrinsic and extrinsic cellular components during embryogenesis. However, the contribution and role of lymphatic vessels (LVs) in LN formation and maturation are poorly defined. Here, using lymphatic-specific reporters, Prox1-GFP mice and Vegfc(+/LacZ) mice, we analyzed migration, assembly, and ingrowth of lymphatic endothelial cells (LECs) in LNs during pre- and postnatal development. RESULTS: Prox1(+) LECs form string-like connections rather than lymph sac-like structures until E14...
December 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27554585/novel-angiogenesis-markers-as-long-term-prognostic-factors-in-patients-with-renal-cell-cancer
#9
Anita M Lampinen, Juha P Virman, Petri Bono, Tiina H Luukkaala, Kaisa L Sunela, Paula M Kujala, Pipsa Saharinen, Pirkko-Liisa I Kellokumpu-Lehtinen
OBJECTIVE: To evaluate Ang-2 expression alone and in combination with expression of cell proliferation and cell survival markers (MIB-1 and Bcl-2) and angiogenesis markers (VEGFR3 and CD31), and the associations of these markers with renal cell cancer (RCC) in long-term survival. PATIENTS AND METHODS: Our study included 224 patients with RCC who were treated before the availability of antiangiogenic agents between 1985 and 1995, at the Pirkanmaa Hospital District in Finland...
July 21, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27553977/total-saponins-of-panaxnotoginseng-promotes-lymphangiogenesis-by-activation-vegf-c-expression-of-lymphatic-endothelial-cells
#10
Jinlong Li, Yan Chen, Li Zhang, Lianping Xing, Hao Xu, Yongjun Wang, Qi Shi, Qianqian Liang
ETHNOPHARMACOLOGICAL RELEVANCE: Lymphatic system plays an important role in maintaining the fluid homeostasis and normal immune responses, anatomic or functional obstruction of which leads to lymphedema, and treatments for therapeutic lymphangiogenesis are efficiency for secondary lymphedema. Total saponins of panaxnotoginseng (PNS) are a mixture isolated from Panaxnotoginseng (Burkill) F.H.Chen, which has been used as traditional Chinese medicine in China for treatment of cardio- and cerebro-vascular diseases...
December 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27549240/interleukin-12-shows-a-better-curative-effect-on-lung-cancer-than-paclitaxel-and-cisplatin-doublet-chemotherapy
#11
Ting Yue, Xiaodong Zheng, Yaling Dou, Xiaohu Zheng, Rui Sun, Zhigang Tian, Haiming Wei
BACKGROUND: Interleukin 12 (IL-12) is a cytokine that has been reported to exhibit potent tumoricidal effects in animal tumor models. A combined approach using Paclitaxel and platinum-based doublet chemotherapy is the most commonly used backbone regimen for treating lung cancer. Despite numerous studies regarding the anti-tumor effects of IL-12 and the widespread use of conventional chemotherapy, few direct comparisons of IL-12 and conventional chemotherapy in the treatment of lung cancer have been performed...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27527412/pathway-related-molecules-of-vegfc-d-vegfr3-nrp2-axis-in-tumor-lymphangiogenesis-and-lymphatic-metastasis
#12
REVIEW
Jingwen Wang, Yuhong Huang, Jun Zhang, Yuanyi Wei, Salma Mahoud, Ahmed Musa Hago Bakheet, Li Wang, Shuting Zhou, Jianwu Tang
Precondition for tumor lymphatic metastasis is that tumor cells induce formation of original and newborn lymphatic vessels and invade surrounding lymphatic vessels in tumor stroma, while some pathway-related molecules play an important role in mechanisms associated with proliferation and migration of lymphatic endothelial cells (LECs) and tumor cells. In lymphangiogenesis and lymphatic metastasis, the pathway-related molecules of VEGFC/D-VEGFR3/NRP2 axis, such as Furin-like enzyme, CNTN1, Prox1, LYVE-1, Podoplanin, SOX18, SDF1 and CXCR4, are direct constitutors as a portion of VEGFC/D-VEGFR3/NRP2 axis, and their biological activities rely on this ligand-receptor system...
October 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27525437/lymphatic-vessels-regulate-immune-microenvironments-in-human-and-murine-melanoma
#13
Amanda W Lund, Marek Wagner, Manuel Fankhauser, Eli S Steinskog, Maria A Broggi, Stefani Spranger, Thomas F Gajewski, Kari Alitalo, Hans P Eikesdal, Helge Wiig, Melody A Swartz
Lymphatic remodeling in tumor microenvironments correlates with progression and metastasis, and local lymphatic vessels play complex and poorly understood roles in tumor immunity. Tumor lymphangiogenesis is associated with increased immune suppression, yet lymphatic vessels are required for fluid drainage and immune cell trafficking to lymph nodes, where adaptive immune responses are mounted. Here, we examined the contribution of lymphatic drainage to tumor inflammation and immunity using a mouse model that lacks dermal lymphatic vessels (K14-VEGFR3-Ig mice)...
September 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27520484/chemotherapy-enhances-tumor-vascularization-via-notch-signaling-mediated-formation-of-tumor-derived-endothelium-in-breast-cancer
#14
Peng Zhang, Dongxu He, Zhen Chen, Qiongxi Pan, Fangfang Du, Xian Zang, Yan Wang, Chunlei Tang, Hong Li, He Lu, Xiaoqiang Yao, Jian Jin, Xin Ma
It is believed that tumor cells can give rise to endothelial cells and tumor endothelium has a neoplastic origin. Yet, the stimuli and underlying mechanism remain unclear. Here, we demonstrate that adriamycin or paclitaxel, first-line chemotherapy agent, induced breast cancer cells to generate morphological, phenotypical and functional features of endothelial cells in vitro. In xenografts models, challenges from adriamycin or paclitaxel induced cancer cells to generate the majority of microvessels. Importantly, in breast cancer specimens from patients with neoadjuvant anthracycline-based or taxane-based chemotherapy, tumor-derived endothelial microvessels, lined by EGFR-amplified or/and TP53(+)-CD31(+) endothelial cells, was significantly higher in patients with progressive or stable disease (PD/SD) than in those with a partial or complete response (PR/CR)...
October 15, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27512727/a-small-molecule-based-strategy-for-endothelial-differentiation-and-three-dimensional-morphogenesis-from-human-embryonic-stem-cells
#15
Yijie Geng, Bradley Feng
The emerging models of human embryonic stem cell (hESC) self-organizing organoids provide a valuable in vitro platform for studying self-organizing processes that presumably mimic in vivo human developmental events. Here we report that through a chemical screen, we identified two novel and structurally similar small molecules BIR1 and BIR2 which robustly induced the self-organization of a balloon-shaped three-dimensional structure when applied to two-dimensional adherent hESC cultures in the absence of growth factors...
July 2016: Heliyon
https://www.readbyqxmd.com/read/27512293/negative-pressure-wound-therapy-induces-early-wound-healing-by-increased-and-accelerated-expression-of-vascular-endothelial-growth-factor-receptors
#16
Tsuruhito Tanaka, Nirmal Panthee, Yoshifumi Itoda, Naoko Yamauchi, Masashi Fukayama, Minoru Ono
BACKGROUND: Negative pressure wound therapy (NPWT) is commonly used to accelerate wound healing, especially following thoracic surgery; however, the mechanism remains elusive. Given the important role of vasculogenesis in wound healing, we evaluated whether NPWT might accelerate vasculogenesis in the wound area. Toward this end, we investigated the temporal expression of vascular endothelial growth factor receptors (VEGFRs) in an NPWT-wound healing rabbit model. METHODS: Rabbits were divided into an NPWT group and a non-NPWT control group, and tissue samples were collected around wounds made in the skin of each rabbit at five time points: 0, 7, 14, 21, and 28 days after wound creation...
2016: European Journal of Plastic Surgery
https://www.readbyqxmd.com/read/27488093/predictive-immunohistochemical-markers-related-to-drug-selection-for-patients-treated-with-sunitinib-or-sorafenib-for-metastatic-renal-cell-cancer
#17
Xin Ma, Lei Wang, Hongzhao Li, Yu Zhang, Yu Gao, Gang Guo, Kan Liu, Qingyu Meng, Chaofei Zhao, Dianjun Wang, Zhigang Song, Xu Zhang
Targeted drug decisions in metastatic renal cell carcinoma are exclusively made on the basis of clinical criteria. We investigated whether these biomarkers (HIF-1α, HIF-2α, CAIX, VEGF, VEGFR1, VEGFR2, VEGFR3, PDGFB, PDGFRA, PDGFRB, CD31, CD44, bcl-xL, KIT, p21, CXCR4, PTEN, (CSF)-1R, RET, and FLT-3) can predictive the different effects between sunitinib and sorafenib treatments and are available to guide targeted drug selection. We enrolled all patients who underwent nephrectomy with postoperative sunitinib- or sorafenib-treatment at our institution from 2007 to 2012...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27477767/the-endoderm-indirectly-influences-morphogenetic-movements-of-the-zebrafish-head-kidney-through-the-posterior-cardinal-vein-and-vegfc
#18
Chih-Wei Chou, Hsiao-Chu Hsu, May-Su You, Jamie Lin, Yi-Wen Liu
Integration of blood vessels and organ primordia determines organ shape and function. The head kidney in the zebrafish interacts with the dorsal aorta (DA) and the posterior cardinal vein (PCV) to achieve glomerular filtration and definitive hematopoiesis, respectively. How the head kidney co-develops with both the axial artery and vein remains unclear. We found that in endodermless sox32-deficient embryos, the head kidney associated with the PCV but not the DA. Disrupted convergent migration of the PCV and the head kidney in sox32-deficient embryos was rescued in a highly coordinated fashion through the restoration of endodermal cells...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27460008/a-taspine-derivative-supresses-caco-2-cell-growth-by-competitively-targeting-ephrinb2-and-regulating-its-pathway
#19
Bingling Dai, Wenjie Wang, Yujiao Ma, Rui Liu, Yanmin Zhang
Colorectal cancer is a common gastrointestinal malignancy worldwide and it is a lethal and aggressive malignancy with a dismal prognosis. In the present study, we investigated the effect of taspine derivative 12k on human colorectal cancer targeted at EphrinB2 and its PDZ. The results indicated that 12k could bind to EphrinB2 and showed a higher suppressive effect on EphrinB2/HEK293 than on HEK293 cells. Caco‑2 cells were screened for high expression of EphrinB2. We found that 12k not only significantly decreased Caco‑2 cell viability and colony formation but impaired migration...
September 2016: Oncology Reports
https://www.readbyqxmd.com/read/27398740/efficacy-of-lenvatinib-in-treating-thyroid-cancer
#20
Jolanta Krajewska, Aleksandra Kukulska, Barbara Jarzab
INTRODUCTION: Radioiodine [RAI]-resistant advanced and progressive differentiated thyroid cancer [DTC], although rare, constitutes a real challenge as its prognosis is poor and available therapeutic options, until now, have been limited. Discovery of a crucial role of distinct tyrosine kinases in DTC pathogenesis opened up new options in systemic treatment. Lenvatinib is an oral potent multi kinase inhibitor [MKI] of different growth factor receptors including VEGFR1/Flt-1, VEGFR2/KDR, VEGFR3, FGFR1,2,3,4, PDGFR-β as well as RET and KIT signaling networks...
August 2016: Expert Opinion on Pharmacotherapy
keyword
keyword
88026
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"