keyword
https://read.qxmd.com/read/38537154/the-future-of-liver-transplantation
#1
JOURNAL ARTICLE
Sandy Feng, Garrett R Roll, Foad J Rouhani, Alberto Sanchez Fueyo
Over the last 50 years, liver transplantation has evolved into a procedure routinely performed in many countries worldwide. Those able to access this therapy frequently experience a miraculous risk-benefit ratio since, particularly if they face imminently life threatening disease. Over the decades, the success of liver transplantation, with dramatic improvements in early post-transplant survival, has aggressively driven demand. However, in spite of the emergence of living donors to augment deceased donors as a source of organs, supply has lagged far behind demand...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537143/-fusarium-amaranthuense-sp-nov-from-amaranth-is-an-emergent-species-closely-related-to-fusarium-circinatum
#2
JOURNAL ARTICLE
Oliul Hassan, Hyunjoo Ryu, Sang-Yeob Lee, Hyo-Won Choi
Amaranth ( Amaranthus spp. L) is not native to South Korea but cultivated in small scales for ornamental purposes as well as leafy vegetables and pseudo cereals. In this study, a new species within the genus Fusarium was isolated from amaranth, showing stem rot symptoms from a farmer field in Hwaseong, South Korea. The disease is characterized by dark-brown spots with black borders, leading to withering. Phylogenetic analysis based on concatenated sequences of translation elongation factor 1-alpha ( TEF1 ), beta-tubulin ( tub2 ), calmodulin ( cmdA ), RNA polymerase largest subunit ( RPB1 ) and RNA polymerase II second largest subunit ( RPB2 ) genes, revealed that the obtained isolates were formed a distinct clade within the Fusarium fujikuroi species complex and closely related to F ...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537081/performance-of-outbreak-management-plans-for-emerging-plant-diseases-the-case-of-almond-leaf-scorch-caused-by-xylella-fastidiosa-in-mainland-spain
#3
JOURNAL ARTICLE
Martina Cendoya, Elena Lázaro, Ana Navarro-Quiles, Antonio López-Quílez, David Conesa, Antonio Vicent
Outbreak response to quarantine pathogens and pests in the European Union (EU) is regulated by the EU Plant Health Law, but the performance of outbreak management plans in terms of their effectiveness and efficiency has been quantified only to a limited extent. As a case study, the disease dynamics of almond leaf scorch, caused by Xylella fastidiosa ( Xf ), in the affected area of Alicante, Spain, were approximated using an individual-based spatial epidemiological model. The emergence of this outbreak was dated based on phylogenetic studies, and official surveys were used to delimit the current extent of the disease...
March 27, 2024: Phytopathology
https://read.qxmd.com/read/38537056/perioperative-outcomes-and-long-term-survival-of-cryosurgery-on-unresectable-pancreatic-cancer-a-systematic-review-and-meta-analysis
#4
JOURNAL ARTICLE
Kang Xue, Xiaofeng Liu, Xiaolin Xu, Li Wang, Bole Tian
BACKGROUND: Pancreatic cancer (PC) continues to rank as one of the deadliest forms of cancer, with the majority of patients being diagnosed with unresectable disease. The implementation of cryoablation-based comprehensive treatment is expected to lead to a reduction in tumor size and potentially achieve complete resection. However, the availability of systematic and evidence-based treatment guidelines for cryoablation in pancreatic cancer is currently limited. MATERIALS AND METHODS: A computerized search was conducted in the Medline, Embase, Cochrane Library databases, and Clinicaltrials to retrieve studies published from August 1987 to June 2023...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38536999/occurrence-of-arbovirus-infections-in-two-riverine-populations-in-the-municipality-of-humait%C3%A3-amazonas-brazil
#5
JOURNAL ARTICLE
Jaqueline Carvalho de Oliveira Silva, Igor Rodrigo Ferreira Siqueira, Leormando Fortunato Dornelas, Cristhian Magalhães Ribeiro, João Pedro Berno Gomes, Iagor Wingenbah Guadagnin, Antonieta Relvas Pereira, Genimar Rebouças Julião, Juliana de Souza Almeida Aranha Camargo, Sergio Almeida Basano, Luís Marcelo Aranha Camargo
BACKGROUND: The riverine communities of the Amazon comprise different social groups that inhabit the rural areas on the banks of rivers and lakes. Residents usually travel by river to rural and urban areas and are then exposed to urbanized diseases such as those caused by arbovirus infection. In Brazil, emerging diseases such as dengue, Zika, chikungunya, and those caused by infection with Oropouche and Mayaro viruses necessitate epidemiological surveillance. This study was aimed at determining the frequency of positivity for immunoglobulin (Ig)G and IgM antibodies against Zika, chikungunya, and dengue viruses and performing molecular analyses to detect viral RNA for the Zika, chikungunya, dengue virus, Oropouche, and Mayaro viruses, in the same serum samples obtained from riverside populations...
2024: Revista da Sociedade Brasileira de Medicina Tropical
https://read.qxmd.com/read/38536917/sensitive-detection-of-multiple-blood-biomarkers-via-immunomagnetic-exosomal-pcr-for-the-diagnosis-of-alzheimer-s-disease
#6
JOURNAL ARTICLE
Shun Hu, Liding Zhang, Ying Su, Xiaohan Liang, Jie Yang, Qingming Luo, Haiming Luo
Blood exosomes are emerging as potential biomarkers for diagnosing brain diseases such as Alzheimer's disease (AD). There is currently a lack of an ultrasensitive technology for identifying core AD biomarkers in blood exosomes to optimize the utility of biomarkers in clinical practice. Here, an immunomagnetic exosomal polymerase chain reaction (iMEP) platform was developed using DNA-conjugated antibodies for the rapid detection of amyloid-β (Aβ1-40 and Aβ1-42 ) and phosphorylated tau (p-tau396,404 and p-tau181 ) in clinical blood exosomes...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536898/clonal-hematopoiesis-the-emergent-cvd-risk-factor
#7
JOURNAL ARTICLE
Jesse D Cochran, Kenneth Walsh
No abstract text is available yet for this article.
April 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38536864/sex-related-differences-in-pre-dialysis-trajectories-and-dialysis-initiation-a-french-nationwide-retrospective-study
#8
JOURNAL ARTICLE
Maxime Raffray, Louise Bourasseau, Cécile Vigneau, Cécile Couchoud, Clémence Béchade, François Glowacki, Sahar Bayat
BACKGROUND: In the last two decades, sex and gender differences have been documented in chronic kidney disease (CKD) management, including access to renal replacement therapy and its outcomes. The objectives of this study were to 1) compare the pre-dialysis healthcare utilization in men and women, and 2) examine the sex-specific factors associated with emergency dialysis start. METHODS: Adult patients with CKD who started dialysis in France in 2015 were extracted from the Renal Epidemiology and Information Network registry...
2024: PloS One
https://read.qxmd.com/read/38536716/scratching-beneath-the-surface-an-evaluation-of-the-management-of-scabies-2017-2023
#9
JOURNAL ARTICLE
Bryony Broster, Amanda Clarke, Collins Iwuji, Suneeta Soni
INTRODUCTION: Possible resistance to recommended treatments for scabies has emerged recently. In response to anecdotal reports of a recent increase in treatment failure with permethrin, the British Association for Sexual Health and HIV (BASHH) released a statement alerting members to this. AIMS: To examine attendances and the treatment pathways for scabies cases seen at local sexual health clinics. METHODOLOGY: A case note review of scabies attendances between January 2017 and December 2023 was conducted...
March 27, 2024: International Journal of STD & AIDS
https://read.qxmd.com/read/38536705/from-animal-models-to-gut-on-chip-the-challenging-journey-to-capture-inter-individual-variability-in-chronic-digestive-disorders
#10
JOURNAL ARTICLE
Aicha Kriaa, Vincent Mariaule, Charlotte De Rudder, Amin Jablaoui, Harry Sokol, Paul Wilmes, Emmanuelle Maguin, Moez Rhimi
Chronic digestive disorders are of increasing incidence worldwide with expensive treatments and no available cure. Available therapeutic schemes mainly rely on symptom relief, with large degrees of variability in patients' response to such treatments, underlining the need for new therapeutic strategies. There are strong indications that the gut microbiota's contribution seems to be a key modulator of disease activity and patients' treatment responses. Hence, efforts have been devoted to understanding host-microbe interactions and the mechanisms underpinning such variability...
2024: Gut Microbes
https://read.qxmd.com/read/38536649/emergent-coronary-thrombectomy-for-acute-myocardial-infarction-immediately-following-craniotomy-with-tumor-resection
#11
JOURNAL ARTICLE
Curtis R Ginder, Giselle A Suero-Abreu, Saad S Ghumman, Brian A Bergmark, Omar Arnaout, Robert P Giugliano
The management of perioperative acute myocardial infarction (AMI) following oncologic neurosurgery requires balancing competing risks of myocardial ischemia and postoperative bleeding. There are limited human data to establish the safest timing of antiplatelet or anticoagulation therapy following neurosurgical procedures. For patients with malignancy experiencing AMI in the acute postoperative period, staged percutaneous coronary intervention (PCI) with upfront coronary aspiration thrombectomy followed by delayed completion PCI may offer an opportunity for myocardial salvage while minimizing postoperative bleeding risks...
March 27, 2024: Cardiology and Therapy
https://read.qxmd.com/read/38536648/catheter-ablation-of-ventricular-tachycardia-in-ischemic-heart-disease-what-is-known-and-new-perspectives
#12
REVIEW
Pasquale Valerio Falzone, Sara Vazquez-Calvo, Ivo Roca-Luque
PURPOSE OF THE REVIEW: This review aims to evaluate current evidence regarding ventricular tachycardia ablation in patients with ischemic heart disease and explore novel approaches currently developing to improve procedural and long-term outcomes. RECENT FINDINGS: Recently published trials (PARTITA, PAUSE-SCD, and SURVIVE-VT) have demonstrated the prognostic benefit of prophylactic ventricular tachycardia ablation compared to current clinical practice. Advanced cardiac imaging provides a valuable pre-procedural evaluation of the arrhythmogenic substrate, identifying ablation targets non-invasively...
March 27, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38536629/association-of-premorbid-glp-1ra-and-sglt-2i-prescription-alone-and-in-combination-with-covid-19-severity
#13
JOURNAL ARTICLE
Klara R Klein, Trine J Abrahamsen, Anna R Kahkoska, G Caleb Alexander, Christopher G Chute, Melissa Haendel, Stephanie S Hong, Hemalkumar Mehta, Richard Moffitt, Til Stürmer, Kajsa Kvist, John B Buse
INTRODUCTION: People with type 2 diabetes are at heightened risk for severe outcomes related to COVID-19 infection, including hospitalization, intensive care unit admission, and mortality. This study was designed to examine the impact of premorbid use of glucagon-like peptide-1 receptor agonist (GLP-1RA) monotherapy, sodium-glucose cotransporter-2 inhibitor (SGLT-2i) monotherapy, and concomitant GLP1-RA/SGLT-2i therapy on the severity of outcomes in individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...
March 27, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38536576/bruton-tyrosine-kinase-inhibition-an-effective-strategy-to-manage-waldenstr%C3%A3-m-macroglobulinemia
#14
REVIEW
Reema K Tawfiq, Jithma P Abeykoon, Prashant Kapoor
PURPOSE OF REVIEW: The treatment of Waldenström macroglobulinemia (WM) has evolved over the past decade. With the seminal discoveries of MYD88 and CXCR warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) mutations in WM cells, our understanding of the disease biology and treatment has improved. The development of a new class of agents, Bruton tyrosine kinase inhibitors (BTKi), has substantially impacted the treatment paradigm of WM. Herein, we review the current and emerging BTKi and the evidence for their use in WM...
March 27, 2024: Current Hematologic Malignancy Reports
https://read.qxmd.com/read/38536547/increased-risk-of-nephrolithiasis-an-emerging-issue-in-children-with-congenital-adrenal-hyperplasia-due-to-21-hydroxylase-deficiency
#15
JOURNAL ARTICLE
Mariangela Chiarito, Crescenza Lattanzio, Vito D'Ascanio, Donatella Capalbo, Paolo Cavarzere, Anna Grandone, Francesca Aiello, Giorgia Pepe, Malgorzata Wasniewska, Thomas Zoller, Mariacarolina Salerno, Maria Felicia Faienza
PURPOSE: To investigate the incidence of nephrolithiasis in a cohort of children with congenital adrenal hyperplasia (CAH), and to study if there is an association with the metabolic control of the disease. METHODS: This study was designed as a multicenter 1 year-prospective study involving 52 subjects (35 males) with confirmed molecular diagnosis of CAH due to 21-hydroxylase deficiency (21-OHD). Each patient was evaluated at three different time-points: T0, T1 (+6 months of follow-up), T2 (+12 months of follow up)...
March 27, 2024: Endocrine
https://read.qxmd.com/read/38536516/the-role-of-oxidative-stress-in-the-pathogenesis-of-ocular-diseases-an-overview
#16
REVIEW
Miao Zhang, Ruixue Zhang, Xiaoyue Zhao, Zhongyu Ma, Jizhao Xin, Shuqin Xu, Dadong Guo
Dysregulation of oxidative stress serves as a pivotal predisposing or exacerbating factor in the intricate development of numerous pathological processes and diseases. In recent years, substantial evidence has illuminated the crucial role of reactive oxygen species (ROS) in many fundamental cellular functions, including proliferation, inflammation, apoptosis, and gene expression. Notably, producing free radicals within ROS profoundly impacts a wide range of biomolecules, such as proteins and DNA, instigating cellular damage and impairing vital cellular functions...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536208/metagenomic-sequencing-sheds-light-on-microbes-putatively-associated-with-pneumonia-related-fatalities-of-white-tailed-deer-odocoileus-virginianus
#17
JOURNAL ARTICLE
Melanie B Prentice, Marie L J Gilbertson, Daniel J Storm, Wendy C Turner, Daniel P Walsh, Marie E Pinkerton, Pauline L Kamath
With emerging infectious disease outbreaks in human, domestic and wild animal populations on the rise, improvements in pathogen characterization and surveillance are paramount for the protection of human and animal health, as well as the conservation of ecologically and economically important wildlife. Genomics offers a range of suitable tools to meet these goals, with metagenomic sequencing facilitating the characterization of whole microbial communities associated with emerging and endemic disease outbreaks...
March 2024: Microbial Genomics
https://read.qxmd.com/read/38536202/venous-disorders-as-an-occupational-disease-a-systematic-review-on-epidemiology-pathophysiology-and-modification-strategies
#18
REVIEW
Tobias Hirsch, Uwe Wahl, Eberhard Rabe
<b/> Background: Forced postures are common in the workplace. Work in the primary economic sector is characterised by a high degree of physical activity and movement; however, activities in the secondary and tertiary sectors commonly require workers to stand or sit. An expansion of the tertiary sector in recent decades has meant that people in industrialised and emerging economies primarily sit or stand at work. The aim of the systematic review was to identify occupational factors relating to the presence of chronic venous disease (CVD), to place these in the context of developments in the workplace, and to determine whether measures are in place to prevent CVD...
March 27, 2024: VASA. Zeitschrift Für Gefässkrankheiten
https://read.qxmd.com/read/38536160/validation-of-thermal-imaging-and-the-alt-70-prediction-model-to-differentiate-cellulitis-from-pseudocellulitis
#19
JOURNAL ARTICLE
Michael S Pulia, Rebecca J Schwei, Roxana Alexandridis, Michael R Lasarev, Edward Harwick, Robert Glinert, Ambar Haleem, Jamie Hess, Thomas D Keenan, Joseph A McBride, Robert Redwood
IMPORTANCE: Cellulitis is misdiagnosed in up to 30% of cases due to mimic conditions termed pseudocellulitis. The resulting overuse of antibiotics is a threat to patient safety and public health. Surface thermal imaging and the ALT-70 (asymmetry, leukocytosis, tachycardia, and age ≥70 years) prediction model have been proposed as tools to help differentiate cellulitis from pseudocellulitis. OBJECTIVES: To validate differences in skin surface temperatures between patients with cellulitis and patients with pseudocellulitis, assess the optimal temperature measure and cut point for differentiating cellulitis from pseudocellulitis, and compare the performance of skin surface temperature and the ALT-70 prediction model in differentiating cellulitis from pseudocellulitis...
March 27, 2024: JAMA Dermatology
https://read.qxmd.com/read/38536116/regular-use-of-aspirin-and-statins-reduces-the-risk-of-cancer-in-individuals-with-systemic-inflammatory-diseases
#20
JOURNAL ARTICLE
Jia-Run Lin, Duan-Duan Han, Wei Wei, Qin Zeng, Zi-Xuan Rong, Xue Bai, Yan-Pei Zhang, Jian Wang, Xiao-Ting Cai, Xu-Guang Rao, Si-Cong Ma, Zhong-Yi Dong
Aspirin has shown potential for cancer prevention, but a recent large randomized controlled trial found no evidence for a reduction in cancer risk. Given the anti-inflammatory effects of aspirin, systemic inflammatory diseases (SIDs), such as osteoporosis, cardiovascular diseases, and metabolic diseases, could potentially modify the aspirin-cancer link. To investigate the impact of aspirin in people with SIDs, we conducted an observational study on a prospective cohort of 478,615 UK Biobank participants. Individuals with at least one of the 41 SIDs displayed a higher cancer risk than those without SIDs...
March 27, 2024: Cancer Research
keyword
keyword
88020
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.