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JOURNAL ARTICLE
Ming Zhang, Shuai-Shuai Huang, Wen-Yue He, Wei-Juan Cao, Min-Yi Sun, Ning-Wei Zhu
INTRODUCTION: Basic fibroblast growth factor (bFGF) shows great potential for preventing vascular dementia (VD). However, the blood‒brain barrier (BBB) and low bioavailability of bFGF in vivo limit its application. The present study investigated how nasal administration of bFGF-loaded nanoliposomes (bFGF-lips) affects the impaired learning and cognitive function of VD mice and the underlying mechanism involved. METHODS: A mouse model of VD was established through repeated cerebral ischemia‒reperfusion...
2024: International Journal of Nanomedicine
#22
JOURNAL ARTICLE
Lu Xue, Su Jiang, Xian-Yao Wan
BACKGROUND: Sesamol is a natural antioxidant known for its potent antioxidant and free radical scavenging properties. This study aimed to explore the therapeutic effects and underlying mechanisms of sesamol in the development of renal ischemia-reperfusion injury (IRI) in mice. METHODS: C57BL/6J wild-type mice were divided into 3 groups: IR group, treated with normal saline after undergoing the IRI procedure; Sesamol + IR group, treated with 30 mg/kg/d of sesamol after the IRI procedure; and Sham group, treated with normal saline but not subjected to the IRI process...
February 12, 2024: Transplantation Proceedings
#23
JOURNAL ARTICLE
Hongjing Liu, Feiyang Hu, Zehong Cao, Yi Qu, Hongmei Wen, Xinzhi Wang, Wei Li
NAD(P)H:quinone oxidoreductase 1 (NQO1) is a potential biomarker for breast cancer (BC) diagnosis and prognosis. However, existing fluorescent probes for NQO1 detection have limitations such as short emission wavelength, weak fluorescence response, or large background interference. Here, we developed two novel near-infrared (NIR) fluorescent probes, DCl-Q and DCl2 -Q, that selectively detect NQO1 activity in BC cells and tissues. They consist of a trimethyl-locked quinone as the recognition group and a donor-π-acceptor structure with halogen atoms as the reporter group...
January 20, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
#24
JOURNAL ARTICLE
Doaa Adnan Atshan, Munaf Hashim Zalzala
Cholestasis is a hepatobiliary condition that manifests as acute or chronic and results from disruptions in the bile flow, formation, or secretion processes. The Farnesoid X receptor (FXR) is a vital target for the therapy of cholestasis since it regulates BA homeostasis. Despite the discovery of multiple active FXR agonists, there are still no effective treatments for cholestasis. Papaverine is identified as an FXR agonist.This study investigates papaverine's efficacy and probable mechanism in protecting against alpha naphthylisothiocyanate (ANIT) induced cholestasis...
2024: Curr Res Pharmacol Drug Discov
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JOURNAL ARTICLE
Taehun Lim, Shivani Rajoriya, Bohyeon Kim, Augustine Natasha, Hyeonjoo Im, Hyun Soo Shim, Junsang Yoo, Jong Woo Kim, Eun-Woo Lee, Hye Jin Shin, Soon Ha Kim, Won-Keun Kim
The COVID-19 pandemic caused by SARS-CoV-2 becomes a serious threat to global health and requires the development of effective antiviral therapies. Current therapies that target viral proteins have limited efficacy with side effects. In this study, we investigated the antiviral activity of MIT-001, a small molecule reactive oxygen species (ROS) scavenger targeting mitochondria, against SARS-CoV-2 and other zoonotic viruses in vitro. The antiviral activity of MIT-001 was quantified by RT-qPCR and plaque assay...
February 1, 2024: Virus Research
#26
JOURNAL ARTICLE
Risa Okamoto, Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Keiichi Hosaka
BACKGROUND: Cardamonin is classified as a natural chalcone, and has been reported to possess various bioactive effects. However, there have been limited attempts to utilize cardamonin in the treatment of periodontitis. This study aimed to investigate whether cardamonin has anti-inflammatory effects on human periodontal ligament cells (HPDLCs), which are a component cell of periodontal tissue. Specifically, the study seeks to determine whether cardamonin affects the expression of inflammatory mediators, such as cytokines and adhesion molecules, induced by interleukin-1β (IL-1β) in HPDLCs, as well as the signaling pathways activated by IL-1β...
January 28, 2024: Molecular Biology Reports
#27
JOURNAL ARTICLE
Jiangzhou Song, Guiqing Zou, Zhou Zhao, Ya Zhu, Jiayu Xue, Lanjia Ao, Huiyong Sun, Haiping Hao, Bo Zhang, Xiaowei Xu
NAD(P)H: quinone oxidoreductase 1 (NQO1) is a flavin protease highly expressed in various cancer cells. NQO1 catalyzes a futile redox cycle in substrates, leading to substantial reactive oxygen species (ROS) production. This ROS generation results in extensive DNA damage and elevated poly (ADP-ribose) polymerase 1 (PARP1)-mediated consumption of nicotinamide adenine dinucleotide (NAD+ ), ultimately causing cell death. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD+ salvage synthesis pathway, emerges as a critical target in cancer therapy...
January 2024: Chinese Journal of Natural Medicines
#28
JOURNAL ARTICLE
Serena Jasmine Aleo, Valentina Del Dotto, Martina Romagnoli, Claudio Fiorini, Giada Capirossi, Camille Peron, Alessandra Maresca, Leonardo Caporali, Mariantonietta Capristo, Concetta Valentina Tropeano, Claudia Zanna, Fred N Ross-Cisneros, Alfredo A Sadun, Maria Gemma Pignataro, Carla Giordano, Chiara Fasano, Andrea Cavaliere, Anna Maria Porcelli, Gaia Tioli, Francesco Musiani, Alessia Catania, Costanza Lamperti, Stefania Bianchi Marzoli, Annamaria De Negri, Maria Lucia Cascavilla, Marco Battista, Piero Barboni, Michele Carbonelli, Giulia Amore, Chiara La Morgia, Dmitrii Smirnov, Catalina Vasilescu, Aiman Farzeen, Beryll Blickhaeuser, Holger Prokisch, Claudia Priglinger, Bettina Livonius, Claudia B Catarino, Thomas Klopstock, Valeria Tiranti, Valerio Carelli, Anna Maria Ghelli
Idebenone, the only approved treatment for Leber hereditary optic neuropathy (LHON), promotes recovery of visual function in up to 50% of patients, but we can neither predict nor understand the non-responders. Idebenone is reduced by the cytosolic NAD(P)H oxidoreductase I (NQO1) and directly shuttles electrons to respiratory complex III, bypassing complex I affected in LHON. We show here that two polymorphic variants drastically reduce NQO1 protein levels when homozygous or compound heterozygous. This hampers idebenone reduction...
January 17, 2024: Cell reports medicine
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JOURNAL ARTICLE
Santosh Kumar Behera, Christoffer Briggs Lambring, Albina Hashmi, Sriharika Gottipolu, Riyaz Basha
OBJECTIVE: NAD(P)H: Quinone oxidoreductase1 (NQO1) plays a crucial role in cellular defense against oxidative stress. Overexpression of NQO1 is linked to various cancer pathways. Despite its potential, the actual mechanisms to inhibit NQO1 and increase the efficacy of standard therapeutic options are not yet established. Resveratrol is an anti-cancer polyphenol found in dietary products and red wine. The objective of this investigation is to employ in silico methods to explore how resveratrol interacts with NQO1...
December 2023: European journal of biology
#30
JOURNAL ARTICLE
NQO1 Mediates Lenvatinib Resistance by Regulating ROS-induced Apoptosis in Hepatocellular Carcinoma.
Wei Xue, Ting Wang, Wen-Jing Tian, Si-Qi Pang, Hua-Feng Zhang, Wei-Dong Jia
OBJECTIVE: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death worldwide. As a first-line drug for advanced HCC treatment, lenvatinib faces a significant hurdle due to the development of both intrinsic and acquired resistance among patients, and the underlying mechanism remains largely unknown. The present study aims to identify the pivotal gene responsible for lenvatinib resistance in HCC, explore the potential molecular mechanism, and propose combinatorial therapeutic targets for HCC management...
January 13, 2024: Current Medical Science
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JOURNAL ARTICLE
Wei-Zheng Zhang, Xiao-Ming Qi, Yu-Qin Zuo, Qing-Shan Li
This paper aims to investigate the protective effect and mechanism of Astragalus membranaceus and Angelica sinensis before and after compatibility against triptolide(TP)-induced hepatotoxicity. The experiment was divided into a blank group, model group, Astragalus membranaceus group, Angelica sinensis group, and compatibility groups with Astragalus membranaceus/Angelica sinensis ratio of 1∶1, 2∶1, and 5∶1. TP-induced hepatotoxicity model was established, and corresponding drug intervention was carried out...
December 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
#32
JOURNAL ARTICLE
Wenjun Li, Yuanyuan Li, Qi Wang, Runze Liu, Jianing Lu, Wenju Lu, Song Qin
INTRODUCTION: The prevention and treatment of chronic obstructive pulmonary disease (COPD) is closely tied to anti-oxidation and anti-inflammation. Phycocyanin (PC) have numerous pharmacological effects such as anti-oxidation, anti-inflammation, and so on. But it remains unclear whether PC can play a therapeutic role in COPD. OBJECTIVE: As inflammation and oxidative stress can aggravate the COPD, this study is to explore the effect of PC on COPD mice and its mechanisms...
January 9, 2024: Journal of Advanced Research
#33
JOURNAL ARTICLE
Mohammed A Alqahtani, Mahmoud A El-Ghiaty, Sara R El-Mahrouk, Ayman O S El-Kadi
Methylmercury (MeHg) and 2,3,7,8-tetrachlorodibenzodioxin (TCDD) are potent environmental pollutants implicated in the modulation of xenobiotic-metabolizing enzymes, particularly the cytochrome P450 1 family (CYP1) which is regulated by the aryl hydrocarbon receptor (AHR). However, the co-exposure to MeHg and TCDD raises concerns about their potential combined effects, necessitating thorough investigation. The primary objective of this study was to investigate the individual and combined effects of MeHg and TCDD on AHR-regulated CYP1 enzymes in mouse extrahepatic tissues...
January 10, 2024: Biological Trace Element Research
#34
JOURNAL ARTICLE
Ahmed Ismaeel, Mary M McDermott, Jai K Joshi, Jada C Sturgis, Dongxue Zhang, Karen J Ho, Robert Sufit, Luigi Ferrucci, Charlotte A Peterson, Kate Kosmac
The pathophysiology of muscle damage in peripheral artery disease (PAD) includes increased oxidant production and impaired antioxidant defenses. Epicatechin (EPI), a naturally occurring flavanol, has antioxidant properties which may mediate the beneficial effects of natural products such as cocoa. In a Phase II randomized trial, a cocoa-flavanol rich beverage significantly improved walking performance compared to placebo in people with PAD. In the present work, the molecular mechanisms underlying the therapeutic effect of cocoa flavanols were investigated by analyzing baseline and follow-up muscle biopsies from participants...
January 8, 2024: American Journal of Physiology. Cell Physiology
#35
JOURNAL ARTICLE
Hua Rong, Xiaoming Li, Chunlei Yu, Wenbao Wang, Libo Li, Tianjiao Xu, Yisong Ding, Yingshi Su, Xiaoli Wang
Oxidative stress is a pivotal stimulating factor in neurocyte apoptosis and has been involved in the pathogenesis of Parkinson's disease (PD). In this study, we have demonstrated that the improvement in the motor disorder of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)/Pro-induced mice caused by b-Ecdysterone (b-Ecd) treatment is due to its antioxidant properties. Using open field, rotarod, and pole climbing tests, we have found that b-Ecd alleviates motor disorder in MPTP/Pro-induced mice and ultimately reduces the impairment of tyrosine hydroxylase (TH)-positive dopaminergic neurons in the substantia nigra (SN)...
January 4, 2024: Folia Neuropathologica
#36
REVIEW
Li Yuhan, Maryam Khaleghi Ghadiri, Ali Gorji
NAD(P)H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation of neuronal function and synaptic plasticity, cellular adaptation to oxidative stress, neuroinflammatory and degenerative processes, and tumorigenesis in the central nervous system (CNS). Impairment of the NQO1 activity in the CNS can result in abnormal neurotransmitter release and clearance, increased oxidative stress, and aggravated cellular injury/death. Furthermore, it can cause disturbances in neural circuit function and synaptic neurotransmission...
January 2, 2024: Journal of Translational Medicine
#37
JOURNAL ARTICLE
Fang Cheng, Yongtai Zhang, Hongli Xiong, Minzhu Zhao, Qi Wang, Ying Zhu, Yongguo Li, Renkuan Tang, Jianbo Li
Doxorubicin (DOX) is one of the most widely used antineoplastic drugs with known cardiotoxicity while other organ toxicity, such as hepatotoxicity is not well defined. This study was to explore the role of nicotinamide adenine dinucleotide (NAD+ ) in DOX-induced hepatotoxicity. DOX (20 mg/kg) induced acute liver injury and oxidative stress in C57BL/6 J mice at 48 h. Notably, the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and NAD(P)H dehydrogenase quinone 1 (NQO1) were downregulated...
December 29, 2023: Toxicology and Applied Pharmacology
#38
JOURNAL ARTICLE
Qizhen Zheng, Tianyu Ma, Ming Wang
ConspectusProenzymes, functioning as inactive precursor forms of enzymes, hold significant promise for regulating essential biological processes. Their inherent property of latency, remaining inert until they arrive at the intended site of action, positions them as particularly promising candidates for the development of targeted therapeutics. Despite this potential, the therapeutic potential of proenzymes is challenged by designing proenzymes with excellent selectivity for disease cells. This limitation is further exacerbated by the inability of proenzymes to spontaneously cross the cell membrane, a biological barrier that impedes the cellular internalization of exogenous macromolecules...
December 24, 2023: Accounts of Chemical Research
#39
JOURNAL ARTICLE
Jiangwei Wang, Xiaolin Su, Lingxiang Jiang, Matthew W Boudreau, Lindsay E Chatkewitz, Jessica A Kilgore, Kashif Rafiq Zahid, Noelle S Williams, Yaomin Chen, Shaohui Liu, Paul J Hergenrother, Xiumei Huang
Lung and breast cancers rank as two of the most common and lethal tumors, accounting for a substantial number of cancer-related deaths worldwide. While the past two decades have witnessed promising progress in tumor therapy, developing targeted tumor therapies continues to pose a significant challenge. NAD(P)H quinone oxidoreductase 1 (NQO1), a two-electron reductase, has been reported as a promising therapeutic target across various solid tumors. β-Lapachone (β-Lap) and deoxynyboquinone (DNQ) are two NQO1 bioactivatable drugs that have demonstrated potent antitumor effects...
December 14, 2023: Cancers
#40
JOURNAL ARTICLE
Hamza M Assiry, Ahmed R Hamed, Gamal A Mohamed, Sabrin R M Ibrahim, Abdulrahman E Koshak, Azizah M Malebari, Sana A Fadil, Hossam M Abdallah
Extraction and fractionation of Barleria trispinosa growing in Saudi Arabia yielded four iridoid compounds identified by spectroscopic techniques as acetylbarlerin ( 1 ), barlerin ( 2 ), shanzhiside methyl ester ( 3 ) and 6-⍺-L-rhamnopyranosyl-8-O-acetylshanzihiside methyl ester ( 4 ). Preliminary experiments confirmed that compound 1 acts as an inducer of chemopreventive NAD(P)H:Quinone oxidoreductase 1 (NQO1) enzymatic activity in a murine hepatoma (Hepa1c1c7) chemoprevention model. It also demonstrated the ability to inhibit the lipopolysaccharides (LPS)-induced nitric oxide (NO) production in the RAW264...
December 20, 2023: Journal of Biomolecular Structure & Dynamics
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