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https://www.readbyqxmd.com/read/28551905/-molecular-markers-for-prostate-cancer
#1
REVIEW
Dov Engelstein
Prostate cancer (PCa) is the most frequent malignancy and the second cause of death from malignancy in men in the Western world. Prostatic Specific Antigen (PSA) has been widely used as a possible marker for PCa for the last three decades, but its significant limitations are known, especially its lack of an exact cutoff level for diagnosis of PCa. Imprudent use of PSA has led to over-diagnosis and over-treatment in men with low risk PCa, not significant for survival. Therefore, researchers are looking for better and more accurate markers for diagnosis, treatment decisions and follow-up...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28551895/-sentinel-lymph-nodes-dissection-in-gynecological-malignancies
#2
REVIEW
Yael Naaman, Limor Goldenhersh, Alon Ben-Arie
During the last decade sentinel lymph nodes biopsy has become an essential part of primary surgical treatment in a number of malignancies including breast cancer, melanoma and head-and-neck malignancies. Dye or radioactive substances are injected at the primary tumor site, followed by pre-operative and intra-operative mapping. During surgery only positive lymph nodes are being dissected instead of a complete dissection of the lymphatic basin. The advantages of sentinel lymph nodes dissection are reducing the side effects of extensive lymph nodes dissection, while maintaining high detection rates and sensitivity in identifying cases with lymphatic tumor spread...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551890/-the-challenge-of-providing-high-standard-medical-services-in-a-public-hospital
#3
Shay Nathanson, Carlos Gruzman
Kaplan Medical Center (KMC) provides medical services to about 1 million Israeli citizens. The southern plain region is one of the leading areas in terms of population growth in Israel and as a result, the demand for medical services is constantly on the rise. The workload at KMC is tremendous; over 140,000 referrals to the emergency department with a 6% increase each year. Bed occupancy in the internal wards is above 120% on average per year (the highest in Israel) and ambulatory care referrals are rising at an overwhelming pace...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551865/pearls-and-pitfalls-of-hepatobiliary-and-splenic-trauma-what-every-trauma-radiologist-needs-to-know
#4
REVIEW
Joseph A Graves, Tarek N Hanna, Keith D Herr
With the universal acceptance of contrast-enhanced computed tomography (CT) as the imaging modality of first resort in the assessment of blunt abdominal injury, the trauma radiologist must be able to accurately and rapidly identify the range of CT manifestations of the traumatized abdomen. In this article, we lay out the fundamental principles in CT interpretation of blunt trauma to the hepatobiliary system and spleen, including vascular injury, with a focus on technical and interpretive pearls and pitfalls...
May 27, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28551858/cost-effectiveness-of-drug-treatments-for-advanced-melanoma-a-systematic-literature-review
#5
REVIEW
Darío Rubio-Rodríguez, Silvia De Diego Blanco, Maite Pérez, Carlos Rubio-Terrés
BACKGROUND: Until recently, advanced melanoma (unresectable and metastatic) has had a poor prognosis and has been treated with chemotherapy. The introduction of new treatments (BRAF and MEK inhibitors and immunotherapy) has improved overall survival and progression-free survival of some patients. OBJECTIVE: The objective of this study was to review the published evidence on the cost-effectiveness of pharmacological treatments for advanced melanoma. METHODS: A systematic literature search was conducted, without date or language restrictions, in PubMed, EMBASE, Scopus, the Cochrane Library, the UK National Institute for Health and Care Excellence databases and the Health Technology Assessment journal...
May 27, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28551729/use-of-platelet-rich-fibrin-in-regenerative-dentistry-a-systematic-review
#6
REVIEW
Richard J Miron, Giovanni Zucchelli, Michael A Pikos, Maurice Salama, Samuel Lee, Vincent Guillemette, Masako Fujioka-Kobayashi, Mark Bishara, Yufeng Zhang, Hom-Lay Wang, Fatiha Chandad, Cleopatra Nacopoulos, Alain Simonpieri, Alexandre Amir Aalam, Pietro Felice, Gilberto Sammartino, Shahram Ghanaati, Maria A Hernandez, Joseph Choukroun
OBJECTIVES: Research across many fields of medicine now points towards the clinical advantages of combining regenerative procedures with platelet-rich fibrin (PRF). This systematic review aimed to gather the extensive number of articles published to date on PRF in the dental field to better understand the clinical procedures where PRF may be utilized to enhance tissue/bone formation. MATERIALS AND METHODS: Manuscripts were searched systematically until May 2016 and separated into the following categories: intrabony and furcation defect regeneration, extraction socket management, sinus lifting procedures, gingival recession treatment, and guided bone regeneration (GBR) including horizontal/vertical bone augmentation procedures...
May 27, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28551458/maternal-substance-use-and-child-protection-a-rapid-evidence-assessment-of-factors-associated-with-loss-of-child-care
#7
REVIEW
Martha Canfield, Polly Radcliffe, Sally Marlow, Marggie Boreham, Gail Gilchrist
This article reviews the literature on the factors associated with mothers who use substances losing care of their children. A rapid evidence assessment was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analyses. Medline and PsycINFO databases were searched to identify primary research studies published in English during January 2000-September 2016. Studies were included if they presented individual, formal support (e.g., receiving substance use treatment) or informal support (e...
May 25, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28551388/anaplastic-lymphoma-kinase-protein-positive-diffuse-large-b-cell-lymphoma-a-developing-world-experience
#8
Huzaifah Salat, Nasir Ud Din, Tariq Moatter, Naila Kayani, Arsalan Ahmed
Anaplastic lymphoma kinase (ALK) positive diffuse large B-cell lymphoma (ALK+DLBCL) is a rare, distinct and aggressive subtype of non-Hodgkin's lymphoma (NHL). These tumors are considered to be derived from post-germinal center B cells but peculiarly their distinction is based on the fact that they are ALK-positive neoplastic B cells but lack expression of B cell markers (CD19,CD20, CD79a), T cell markers (CD3, CD5) and CD30. Its broad differential diagnosis and similarities to plasmablastic lymphoma, immunoblastic DLBCL, Anaplastic large-cell lymphoma (ALCL) of T-null cell lineage, and poorly differentiated/anaplastic carcinoma pose a grave challenge to physicians with conventional costly treatment for DLBCL failing to yield any clinical or prognostic significance in ALK+DLBCL...
March 6, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28551335/transition-path-times-measured-by-single-molecule-spectroscopy
#9
REVIEW
Hoi Sung Chung
The transition path is a tiny fraction of a molecular trajectory during which the free-energy barrier is crossed. It is a single-molecule property and contains all mechanistic information of folding processes of biomolecules such as proteins and nucleic acids. However, the transition path has been difficult to probe because it is short and rarely visited when transitions actually occur. Recent technical advances in single-molecule spectroscopy have made it possible to directly probe transition paths, which has opened up new theoretical and experimental approaches to investigating folding mechanisms...
May 24, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28551287/osteochondritis-dissecans-development
#10
REVIEW
Stacy A Semevolos
This article reviews current knowledge of osteochondritis dissecans (OCD) development in horses, including normal cartilage development, early osteochondrosis pathogenesis, and factors that result in healing or advancement to OCD fragments. Discussion includes current theories, detection, and therapeutic options.
May 25, 2017: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/28551163/therapies-for-macular-edema-associated-with-branch-retinal-vein-occlusion-a-report-by-the-american-academy-of-ophthalmology
#11
Justis P Ehlers, Stephen J Kim, Steven Yeh, Jennifer E Thorne, Prithvi Mruthyunjaya, Scott D Schoenberger, Sophie J Bakri
PURPOSE: To evaluate the available evidence on the ocular safety and efficacy of current therapeutic alternatives for the management of macular edema (ME) secondary to branch retinal vein occlusion (BRVO). METHODS: Literature searches were last conducted on January 31, 2017, in PubMed with no date restrictions and limited to articles published in English, and in the Cochrane Database without language limitations. The searches yielded 321 citations, of which 109 were reviewed in full text and 27 were deemed appropriate for inclusion in this assessment...
May 24, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28551068/therapeutic-targets-in-the-management-of-striae-distensae-a-systematic-review
#12
REVIEW
Adam Hague, Ardeshir Bayat
BACKGROUND: Striae distensae are permanent dermal lesions that can cause significant psychosocial distress. A detailed understanding of the numerous treatment modalities available is essential to ensuring optimal patient outcomes. OBJECTIVE: Our objective was to evaluate and summarize the different treatment methods for striae distensae by linking their proposed modes of action with the histopathogenesis of the condition to guide patient treatment. METHODS: A systematic review of the literature was performed with no limits placed on publication date...
May 24, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28550936/the-bare-necessities-a-realist-review-of-necessity-argumentations-used-in-health-care-coverage-decisions
#13
REVIEW
Tineke Kleinhout-Vliek, Antoinette de Bont, Bert Boer
CONTEXT: Policy makers and insurance companies decide on coverage of care by both calculating (cost-) effectiveness and assessing the necessity of coverage. AIM: To investigate argumentations pertaining to necessity used in coverage decisions made by policy makers and insurance companies, as well as those argumentations used by patients, authors, the public and the media. METHODS: This study is designed as a realist review, adhering to the RAMESES quality standards...
May 5, 2017: Health Policy
https://www.readbyqxmd.com/read/28550868/esophageal-replacement
#14
Shaun M Kunisaki, Arnold G Coran
This article focuses on esophageal replacement as a surgical option for pediatric patients with end-stage esophageal disease. While it is obvious that the patient׳s own esophagus is the best esophagus, persisting with attempts to retain a native esophagus with no function and at all costs are futile and usually detrimental to the overall well-being of the child. In such cases, the esophagus should be abandoned, and the appropriate esophageal replacement is chosen for definitive reconstruction. We review the various types of conduits used for esophageal replacement and discuss the unique advantages and disadvantages that are relevant for clinical decision-making...
April 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/28550845/the-clinical-management-of-awake-bruxism
#15
Ronald E Goldstein, Wendy Auclair Clark
BACKGROUND: Awake bruxism is a common clinical condition that often goes undetected, often leading to pain or damaged teeth and restorations. METHODS: The authors searched electronic databases regarding the treatment and effects of awake bruxism compared with those of sleep bruxism. The authors used the search terms diurnal bruxism and oral parafunction. The authors combined information from relevant literature with clinical experience to establish a recommended protocol for diagnosis and treatment...
June 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28550785/gender-gaps-and-glass-ceilings-a-survey-of-gender-specific-publication-trends-in-psychiatry-between-1994-and-2014
#16
S Süßenbacher, M Amering, A Gmeiner, B Schrank
BACKGROUND: Within academic psychiatry, women are underrepresented in the higher academic ranks. However, basic determinants of women's lack of academic advancement such as publication activity are poorly understood. The present study examines women's publication activity in high-impact psychiatry journals over two decades and reports developments in the numbers of male and female authorship over time and across cultural areas. METHODS: We conducted a retrospective bibliometric review of all articles published in 2004 and 2014 in three high-ranking general psychiatry journals...
April 6, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28550770/laparoscopic-versus-open-radical-nephrectomy-for-renal-cell-carcinoma-a-systematic-review-and-meta-analysis
#17
Gang Liu, Yulei Ma, Shouhua Wang, Xiancheng Han, Dianjun Gao
BACKGROUND: The aim of this study is to summarize and quantify the current evidence on the therapeutic efficacy of laparoscopic radical nephrectomy (LRN) compared with open radical nephrectomy (ORN) in patients with renal cell carcinoma (RCC) in a meta-analysis. METHODS: Data were collected by searching Pubmed, Embase, Web of Science, and ScienceDirect for reports published up to September 26, 2016. Studies that reported data on comparisons of therapeutic efficacy of LRN and ORN were included...
May 24, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28550764/mechanical-properties-of-crossed-lamellar-structures-in-biological-shells-a-review
#18
REVIEW
X W Li, H M Ji, W Yang, G P Zhang, D L Chen
The self-fabrication of materials in nature offers an alternate and powerful solution towards the grand challenge of designing advanced structural materials, where strength and toughness are always mutually exclusive. Crossed-lamellar structures are the most common microstructures in mollusks that are composed of aragonites and a small amount of organic materials. Such a distinctive composite structure has a fracture toughness being much higher than that of pure carbonate mineral. These structures exhibiting complex hierarchical microarchitectures that span several sub-level lamellae from microscale down to nanoscale, can be grouped into two types, i...
May 17, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28550713/state-of-the-art-on-oocyte-cryopreservation-in-female-cancer-patients-a-critical-review-of-the-literature
#19
REVIEW
Claudia Massarotti, Paola Scaruffi, Matteo Lambertini, Valentino Remorgida, Lucia Del Mastro, Paola Anserini
During the last decades, important advances in therapeutic options have led to increased survival rates in cancer patients; however, cancer treatments are associated with several potential adverse effects including infertility in those diagnosed during their reproductive years. A proper discussion about fertility preservation options before the use of therapies with potential gonadotoxicity (i.e. oncofertility counseling) is standard of care and should be offered to all patients of childbearing age. Temporary ovarian suppression with LH-RH analogs, oocyte and embryo cryopreservation are standard strategies for fertility preservation in female cancer patients...
May 9, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28550637/breaking-bad-the-structure-and-function-of-the-blood-brain-barrier-in-epilepsy
#20
Hadas Han, Aniv Mann, Dana Ekstein, Sara Eyal
Epilepsy is a neurological disease with variable etiology and clinical manifestation, affecting more than 50 million people worldwide. Although the ultimate precipitators of seizures are neurons, it is becoming evident that epileptic activity is associated with changes in the function of other cell types, including those consisting the blood-brain barrier (BBB) and regulating its permeability. The interrelationships between impaired BBB function and epilepsy are complex, as BBB dysfunction may both lead to seizures and be induced by epileptic activity...
May 26, 2017: AAPS Journal
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