D Brabbing-Goldstein, D Kozlova, L Bazak, L Basel-Salmon, Y Gilboa, I Marciano-Levi, J Zahra, B Kanengisser-Pines, A Botvinik, A Kurolap, R Birnbaum, Y Yaron
OBJECTIVES: Mitochondrial complex I deficiency, nuclear type 16 is a rare autosomal recessive disorder caused by biallelic pathogenic variants in NDUFAF5 (C20orf7) [OMIM 618238]. This entity belongs to a genetically and clinically heterogenic group of complex I deficiency which accounts for up to 30% of childhood mitochondrial disorders presenting as Leigh syndrome, leukoencephalopathy, fatal infantile lactic acidosis, and other early-onset neurodegenerative disorders. We present very early, unique, and severe prenatal manifestation of this disorder, previously considered to manifest post-natally...
September 18, 2023: Ultrasound in Obstetrics & Gynecology