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https://www.readbyqxmd.com/read/28885176/applications-of-bioinformatics-to-plant-biotechnology
#1
Diego F Gomez-Casati, María V Busi, Julieta Barchiesi, Diego A Peralta, Nicolás Hedin, Vijai Bhadauria
Bioinformatics encompasses many tools and techniques that today are essential for all areas of research in the biological sciences. New databases with a wealth of information about genomes, proteins, metabolites, and metabolic pathways appear almost daily. Particularly, for scientists who carry out research in plant biology, the amount of information has multiplied exponentially due to the large number of databases available for many individual plant species. In this sense, bioinformatics together with next generation sequencing and 'omics' approaches, can provide tools for plant breeding and the genetic engineering of plants...
September 8, 2017: Current Issues in Molecular Biology
https://www.readbyqxmd.com/read/28884359/development-of-a-shear-stress-free-microfluidic-gradient-generator-capable-of-quantitatively-analyzing-single-cell-morphology
#2
David Barata, Giulia Spennati, Cristina Correia, Nelson Ribeiro, Björn Harink, Clemens van Blitterswijk, Pamela Habibovic, Sabine van Rijt
Microfluidics, the science of engineering fluid streams at the micrometer scale, offers unique tools for creating and controlling gradients of soluble compounds. Gradient generation can be used to recreate complex physiological microenvironments, but is also useful for screening purposes. For example, in a single experiment, adherent cells can be exposed to a range of concentrations of the compound of interest, enabling high-content analysis of cell behaviour and enhancing throughput. In this study, we present the development of a microfluidic screening platform where, by means of diffusion, gradients of soluble compounds can be generated and sustained...
September 7, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28878364/analysis-and-imaging-of-biocidal-agrochemicals-using-tof-sims
#3
Valerio Converso, Sarah Fearn, Ecaterina Ware, David S McPhail, Anthony J Flemming, Jacob G Bundy
ToF-SIMS has been increasingly widely used in recent years to look at biological matrices, in particular for biomedical research, although there is still a lot of development needed to maximise the value of this technique in the life sciences. The main issue for biological matrices is the complexity of the mass spectra and therefore the difficulty to specifically and precisely detect analytes in the biological sample. Here we evaluated the use of ToF-SIMS in the agrochemical field, which remains a largely unexplored area for this technique...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28862626/a-protocol-for-searching-the-most-probable-phase-retrieved-maps-in-coherent-x-ray-diffraction-imaging-by-exploiting-the-relationship-between-convergence-of-the-retrieved-phase-and-success-of-calculation
#4
Yuki Sekiguchi, Saki Hashimoto, Amane Kobayashi, Tomotaka Oroguchi, Masayoshi Nakasako
Coherent X-ray diffraction imaging (CXDI) is a technique for visualizing the structures of non-crystalline particles with size in the submicrometer to micrometer range in material sciences and biology. In the structural analysis of CXDI, the electron density map of a specimen particle projected along the direction of the incident X-rays can be reconstructed only from the diffraction pattern by using phase-retrieval (PR) algorithms. However, in practice, the reconstruction, relying entirely on the computational procedure, sometimes fails because diffraction patterns miss the data in small-angle regions owing to the beam stop and saturation of the detector pixels, and are modified by Poisson noise in X-ray detection...
September 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28855813/saudi-medicinal-plants-for-the-treatment-of-scorpion-sting-envenomation
#5
REVIEW
Abdulrahman Al-Asmari, Rajamohamed Abbas Manthiri, Nasreddien Abdo, Fawzi Abdullah Al-Duaiji, Haseeb Ahmad Khan
Scorpion sting envenoming poses major public health problems. The treatment modalities include antivenoms, chemical antidotes and phytotherapy, with varying degrees of effectiveness and side effects. In this investigation, we reviewed the use of Saudi medicinal plants for the treatment of scorpion sting patients. The relevant literature was collected using the online search engines including Science Direct, Google and PubMed with the help of specific keywords. We also used the printed and online resources at our institutional library to gather the relevant information on the use of medicinal plants for the treatment of scorpion sting patients...
September 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28822173/-breakthrough-in-key-science-and-technologies-in-dendrobium-catenatum-industry
#6
Ji-Ping Si, Qi Wang, Zhong-Jian Liu, Jing-Jing Liu, Yi-Bo Luo
In view of the significant difficulties of propagation, planting and simple product in Dendrobium catenatum(D. officinale)industry development, a series of research were carried out. Genome study showed that D. catenatum is a specie of diploid with 38 chromosomes and 28 910 protein-coding genes. It was identified that specific genes accumulated in different organs at the transcriptome level. We got an insight into the gene regulation mechanism of the loss of the endospermous seed, the wide ecological adaptability and the synthesis of polysaccharides, which provided a theoretical basis for genetic engineering breeding and development and utilization of active pharmaceutical ingredients...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28800754/current-concepts-in-bone-metastasis-contemporary-therapeutic-strategies-and-ongoing-clinical-trials
#7
REVIEW
Andrew S Gdowski, Amalendu Ranjan, Jamboor K Vishwanatha
BACKGROUND: Elucidation of mechanisms regulating bone metastasis has progressed significantly in recent years and this has translated to many new therapeutic options for patients with bone metastatic cancers. However, the rapid rate of progress in both the basic science literature and therapies undergoing clinical trials makes staying abreast with current developments challenging. This review seeks to provide an update on the current state of the science in bone metastasis research and give a snap shot of therapies in clinical trials for bone metastatic cancer...
August 11, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28799377/ice-formation-on-kaolinite-insights-from-molecular-dynamics-simulations
#8
Gabriele C Sosso, Gareth A Tribello, Andrea Zen, Philipp Pedevilla, Angelos Michaelides
The formation of ice affects many aspects of our everyday life as well as important technologies such as cryotherapy and cryopreservation. Foreign substances almost always aid water freezing through heterogeneous ice nucleation, but the molecular details of this process remain largely unknown. In fact, insight into the microscopic mechanism of ice formation on different substrates is difficult to obtain even if state-of-the-art experimental techniques are used. At the same time, atomistic simulations of heterogeneous ice nucleation frequently face extraordinary challenges due to the complexity of the water-substrate interaction and the long time scales that characterize nucleation events...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28794897/uncovering-capgras-delusion-using-a-large-scale-medical-records-database
#9
Vaughan Bell, Caryl Marshall, Zara Kanji, Sam Wilkinson, Peter Halligan, Quinton Deeley
BACKGROUND: Capgras delusion is scientifically important but most commonly reported as single case studies. Studies analysing large clinical records databases focus on common disorders but none have investigated rare syndromes. AIMS: Identify cases of Capgras delusion and associated psychopathology, demographics, cognitive function and neuropathology in light of existing models. METHOD: Combined computational data extraction and qualitative classification using 250 000 case records from South London and Maudsley Clinical Record Interactive Search (CRIS) database...
July 2017: BJPsych Open
https://www.readbyqxmd.com/read/28791282/the-global-health-service-partnership-an-academic-clinical-partnership-to-build-nursing-and-medical-capacity-in-africa
#10
REVIEW
Eileen M Stuart-Shor, Elizabeth Cunningham, Laura Foradori, Elizabeth Hutchinson, Martha Makwero, Jill Smith, Jane Kasozi, Esther M Johnston, Aliasgar Khaki, Elisa Vandervort, Fabiola Moshi, Vanessa B Kerry
The World Health Organization estimates a global deficit of about 12.9 million skilled health professionals (midwives, nurses, and physicians) by 2035. These shortages limit the ability of countries, particularly resource-constrained countries, to deliver basic health care, to respond to emerging and more complex needs, and to teach, graduate, and retain their future health professionals-a vicious cycle that is perpetuated and has profound implications for health security. The Global Health Service Partnership (GHSP) is a unique collaboration between the Peace Corps, President's Emergency Plan for AIDS Relief, Seed and host-country institutions, which aims to strengthen the breadth and quality of medical and nursing education and care delivery in places with dire shortages of health professionals...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28773235/synchrotron-microtomography-reveals-the-fine-three-dimensional-porosity-of-composite-polysaccharide-aerogels
#11
Abdul Ghafar, Kirsti Parikka, David Haberthür, Maija Tenkanen, Kirsi S Mikkonen, Jussi-Petteri Suuronen
This study investigates the impact of ice-templating conditions on the morphological features of composite polysaccharide aerogels in relation to their mechanical behavior and aims to get a better insight into the parameters governing these properties. We have prepared polysaccharide aerogels of guar galactomannan (GM) and tamarind seed xyloglucan (XG) by enzymatic oxidation with galactose oxidase (GaO) to form hydrogels, followed by conventional and unidirectional ice-templating (freezing) methods and lyophilization to form aerogels...
July 28, 2017: Materials
https://www.readbyqxmd.com/read/28756321/enhanced-nucleation-of-diamond-on-three-dimensional-tools-via-stabilized-colloidal-nanodiamond-in-electrostatic-self-assembly-seeding-process
#12
Tao Wang, Stephan Handschuh-Wang, Songquan Zhang, Xuechang Zhou, Yongbing Tang
Nanocrystalline diamond particles are promising candidates for copious applications in materials science, biology and electronics. In this work, diamond nucleation density was unprecedentedly enhanced via a non-invasive electrostatic self-assembly seeding approach. By addition of glutamic acid to the nanodiamond seeding solution, the positively charged amino-group of glutamic acid, which is adsorbed on nanodiamond particles, enhances the adsorption on negative charged cemented carbide substrate. The highest nucleation density (1...
November 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28754140/assessing-citation-networks-for-dissemination-and-implementation-research-frameworks
#13
Ted A Skolarus, Todd Lehmann, Rachel G Tabak, Jenine Harris, Jesse Lecy, Anne E Sales
BACKGROUND: A recent review of frameworks used in dissemination and implementation (D&I) science described 61 judged to be related either to dissemination, implementation, or both. The current use of these frameworks and their contributions to D&I science more broadly has yet to be reviewed. For these reasons, our objective was to determine the role of these frameworks in the development of D&I science. METHODS: We used the Web of Science™ Core Collection and Google Scholar™ to conduct a citation network analysis for the key frameworks described in a recent systematic review of D&I frameworks (Am J Prev Med 43(3):337-350, 2012)...
July 28, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28725415/seed-production-areas-for-the-global-restoration-challenge
#14
Paul G Nevill, Sean Tomlinson, Carole P Elliott, Erin K Espeland, Kingsley W Dixon, David J Merritt
Wild-collected seed can no longer meet global demand in restoration. Dedicated Seed Production Areas (SPA) for restoration are needed and these require application of ecological, economic, and population-genetic science. SPA design and construction must embrace the ecological sustainability principles of restoration.
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28713412/the-emerging-oilseed-crop-sesamum-indicum-enters-the-omics-era
#15
REVIEW
Komivi Dossa, Diaga Diouf, Linhai Wang, Xin Wei, Yanxin Zhang, Mareme Niang, Daniel Fonceka, Jingyin Yu, Marie A Mmadi, Louis W Yehouessi, Boshou Liao, Xiurong Zhang, Ndiaga Cisse
Sesame (Sesamum indicum L.) is one of the oldest oilseed crops widely grown in Africa and Asia for its high-quality nutritional seeds. It is well adapted to harsh environments and constitutes an alternative cash crop for smallholders in developing countries. Despite its economic and nutritional importance, sesame is considered as an orphan crop because it has received very little attention from science. As a consequence, it lags behind the other major oil crops as far as genetic improvement is concerned. In recent years, the scenario has considerably changed with the decoding of the sesame nuclear genome leading to the development of various genomic resources including molecular markers, comprehensive genetic maps, high-quality transcriptome assemblies, web-based functional databases and diverse daft genome sequences...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28707186/natural-oils-for-skin-barrier-repair-ancient-compounds-now-backed-by-modern-science
#16
REVIEW
Alexandra R Vaughn, Ashley K Clark, Raja K Sivamani, Vivian Y Shi
Natural plant oils are commonly used as topical therapy worldwide. They are usually easily accessible and are relatively inexpensive options for skin care. Many natural oils possess specific compounds with antimicrobial, antioxidant, anti-inflammatory, and anti-itch properties, making them attractive alternative and complementary treatments for xerotic and inflammatory dermatoses associated with skin-barrier disruption. Unique characteristics of various oils are important when considering their use for topical skin care...
July 13, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28701046/a-review-of-the-antioxidant-activity-of-celery-apium-graveolens-l
#17
Wesam Kooti, Nahid Daraei
Plants are an important source of natural active products that are different, based on mechanism and biological properties. Celery ( Apium graveolens L) is a plant from the apiaceae family and phenolic and antioxidant compounds of this plant have been studied by several scientists. The aim of this study was to review systematically the antioxidant activity of celery. Required articles were searched from databases such as Science Direct, PubMed, Scopus, and Springer. Keywords used in this study were Apium graveolens L, celery, antioxidant, free radical, leaf, and seed...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28680783/johann-gaspar-spurzheim-a-life-dedicated-to-phrenology
#18
REVIEW
Mohammad Bilal, Bryan Edwards, Marios Loukas, Rod J Oskouian, R Shane Tubbs
Loved for his empathetic nature but admired for his analytical mind, Gaspar Spurzheim (1776-1832) was a prominent contributor to phrenology, a field of neuroscience focused on studying the shapes of the skulls in relation to the activity levels of certain functional areas of the brain. This curiosity about the connection between physical characteristics and brain function was seeded in the young mind of Spurzheim when he observed that classmates with seemingly superb memories also appeared to have bright eyes...
May 30, 2017: Curēus
https://www.readbyqxmd.com/read/28677044/ren%C3%A3-dubos-tuberculosis-and-the-ecological-facets-of-virulence
#19
Mark Honigsbaum
Reflecting on his scientific career toward the end of his life, the French-educated medical researcher René Dubos presented his flowering as an ecological thinker as a story of linear progression-the inevitable product of the intellectual seeds planted in his youth. But how much store should we set by Dubos's account of his ecological journey? Resisting retrospective biographical readings, this paper seeks to relate the development of Dubos's ecological ideas to his experimental practices and his career as a laboratory researcher...
September 2017: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/28675073/designing-interaction-voice-and-inclusion-in-aac-research
#20
Graham Pullin, Jutta Treviranus, Rupal Patel, Jeff Higginbotham
The ISAAC 2016 Research Symposium included a Design Stream that examined timely issues across augmentative and alternative communication (AAC), framed in terms of designing interaction, designing voice, and designing inclusion. Each is a complex term with multiple meanings; together they represent challenging yet important frontiers of AAC research. The Design Stream was conceived by the four authors, researchers who have been exploring AAC and disability-related design throughout their careers, brought together by a shared conviction that designing for communication implies more than ensuring access to words and utterances...
July 4, 2017: Augmentative and Alternative Communication: AAC
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