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https://www.readbyqxmd.com/read/28647729/analgesic-effects-of-diluted-bee-venom-acupuncture-mediated-by-%C3%AE-opioid-and-%C3%AE-2-adrenergic-receptors-in-osteoarthritic-rats
#1
Jeong-Eun Huh, Byung-Kwan Seo, Jung-Woo Lee, Yeon-Cheol Park, Yong-Hyeon Baek
Context • Pain from osteoarthritis is associated with peripheral nociception and central pain processing. Given the unmet need for innovative, effective, and well-tolerated therapies, many patients, after looking for more satisfactory alternatives, decide to use complementary and alternative modalities. The analgesic mechanism of subcutaneous injections of diluted bee venom into an acupoint is thought to be part of an anti-inflammatory effect and the central modulation of pain processing. Objectives • Using the rat model of collagenase-induced osteoarthritis (CIOA), the study intended to investigate the analgesic effects of bee venom acupuncture (BVA) as they are related to the acupuncture points and dosage used and to determine whether the analgesic mechanisms of BVA for pain were mediated by opioid or adrenergic receptors...
June 23, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28646299/effective-combined-water-and-sideband-suppression-for-low-speed-tissue-and-in-vivo-mas-nmr
#2
Yalda Liaghati Mobarhan, Jochem Struppe, Blythe Fortier-McGill, André J Simpson
High-resolution magic angle spinning (HR-MAS) NMR is a powerful technique that can provide metabolic profiles and structural constraints on intact biological and environmental samples such as cells, tissues and living organisms. However, centripetal force from fast spinning can lead to a loss of sample integrity. In analyses focusing on structural organization, metabolite compartmentalization or in vivo studies, it is critical to keep the sample intact. As such, there is growing interest in slow spinning studies that preserve sample longevity...
June 23, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28645772/increased-of-the-hepatocytes-and-splenocytes-apoptosis-accompanies-clinical-improvement-and-higher-survival-in-mice-infected-with-trypanosoma-cruzi-and-treated-with-highly-diluted-lycopodium-clavatum
#3
Gislaine Janaina Falkowski-Temporini, Carina Ribeiro Lopes, Paula Fernanda Massini, Camila Fernanda Brustolin, Fabiana Nabarro Ferraz, Patricia Flora Sandri, Luzmarina Hernandes, Denise Lessa Aleixo, Terezinha Fátima Barion, Luiz Gilson Esper, Silvana Marques de Araújo
Recent evidence includes apoptosis as a defense against Trypanosoma cruzi infection, which promotes an immune response in the host induced by T cells, type 1, 2 and 17. Currently, there is no medicine completely preventing the progression of this disease. We investigated the immunological and apoptotic effects, morbidity and survival of mice infected with T. cruzi and treated with dynamized homeopathic compounds 13c: Kalium causticum (GCaus), Conium maculatum, (GCon), Lycopodium clavatum (GLy) and 7% alcohol solution (control, vehicle compounds, GCI)...
June 20, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28645709/aquatic-biodiversity-in-sedimentation-ponds-receiving-road-runoff-what-are-the-key-drivers
#4
Zhenhua Sun, John E Brittain, Ekaterina Sokolova, Helene Thygesen, Svein Jakob Saltveit, Sebastien Rauch, Sondre Meland
Recently, increased attention has been paid to biodiversity conservation provided by blue-green solutions such as engineered ponds that are primarily established for water treatment and flood control. However, little research has been done to analyse the factors that affect biodiversity in such ponds. The purpose of this study was to evaluate the influence of environmental factors on aquatic biodiversity, mainly macroinvertebrate communities, in road sedimentation ponds in order to provide a foundation for recommendations on aquatic biodiversity conservation...
June 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28645580/chemostat-studies-of-bacteriophage-m13-infected-escherichia-coli-jm109-for-continuous-ssdna-production
#5
Benjamin Kick, Karl Lorenz Behler, Timm Steffen Severin, Dirk Weuster-Botz
Steady state studies in a chemostat enable the control of microbial growth rate at defined reaction conditions. The effects of bacteriophage M13 infection on maximum growth rate of Escherichia coli JM109 were studied in parallel operated chemostats on a milliliter-scale to analyze the steady state kinetics of phage production. The bacteriophage infection led to a decrease in maximum specific growth rate of 15 % from 0.74 h(-1) to 0.63 h(-1). Under steady state conditions, a constant cell specific ssDNA formation rate of 0...
June 20, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28644725/quantifying-structural-modifications-of-gills-of-two-fish-species-astyanax-altiparanae-lambari-and-prochilodus-lineatus-curimbat%C3%A3-after-exposure-to-biodegradable-detergents-in-urban-lake-water
#6
Bruno Fiorelini Pereira, Anderson Luis Alves, José Augusto Senhorini, Priscilla Hakime Scalize, Fellipe Augusto Tocchini De Figueiredo, Dimítrius Leonardo Pitol, Flávio Henrique Caetano
Anthropic actions in rivers and urban lakes are a cause for concern to our ecosystem. The effects on fauna and flora of substances discharged into waterways have become a focus for investigations globally. Biodegradable detergents are widely used in residences and small industries, but little is known regarding the consequences on fish fauna. The objective of the present study was to identify modifications in gill structure in two fish species, Astyanax altiparanae and Prochilodus lineatus, after treatment with water obtained from an urban lake and an exposure to 1 ppm diluted biodegradable detergents (linear alkylbenzene sulfonate)...
June 23, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28643231/demodex-blepharitis-treated-with-a-novel-dilute-povidone-iodine-and-dmso-system-a-case-report
#7
Jesse S Pelletier, Kara Capriotti, Kevin S Stewart, Joseph A Capriotti
INTRODUCTION: Povidone-iodine aqueous solution is an antiseptic commonly used in ophthalmology for treatment of the ocular surface. Dimethylsulfoxide (DMSO) is a well-known skin penetration enhancer that is scarcely utilized in ophthalmic drug formulations. We describe here a low-dose formulation of 0.25% PVP-I in a gel containing DMSO for the treatment of Demodex blepharitis. CASE REPORT: A 95-year-old female presented with chronic blepharitis involving both the anterior and posterior eyelid margins...
June 22, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28642934/evaluation-of-the-antibacterial-and-antifungal-properties-of-phragmanthera-capitata-sprengel-balle-loranthaceae-a-mistletoe-growing-on-rubber-tree-using-the-dilution-techniques
#8
Franklin Uangbaoje Ohikhena, Olubunmi Abosede Wintola, Anthony Jide Afolayan
The alarming increase in multidrug resistance of pathogenic microorganisms to conventional drugs in recent years has prompted the search for new leads in alternative remedies in natural products. Hence, this study was aimed at evaluating the antimicrobial properties of Phragmanthera capitata, a parasitic mistletoe growing on rubber trees. The in vitro antimicrobial activities of the acetone, methanol, ethanol, and aqueous extracts were investigated using five gram-negative and five gram-positive bacteria and four fungi...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28641188/risk-assessment-of-triclosan-released-from-sewage-treatment-plants-in-european-rivers-using-a-combination-of-risk-quotient-methodology-and-monte-carlo-simulation
#9
Vasiliki S Thomaidi, Christos Matsoukas, Athanasios S Stasinakis
Ιn this study a probabilistic risk assessment was applied to investigate the environmental risks for the European aquatic environment associated with triclosan (TCS) occurrence in treated wastewater. The concentrations of TCS in effluents of European Sewage Treatment Plants (STPs) were recorded through literature review, while toxicity data was collected for three groups of aquatic organisms (algae, Daphnia magna and fish). The ratio of Measured Environmental Concentration (MEC) and Predicted No Effect Concentration (PNEC), expressed as a Risk Quotient (RQ), was calculated for risk characterization, while Monte Carlo simulation was applied to quantify the associated uncertainty...
June 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28640321/effects-of-direct-oral-anticoagulants-on-lupus-anticoagulant-assays-in-a-real-life-setting
#10
Aleksandra Antovic, Eva-Marie Norberg, Maria Berndtsson, Agnes Rasmuson, Rickard E Malmström, Mika Skeppholm, Jovan Antovic
Laboratory diagnosis of lupus anticoagulant (LA) is based on prolongation in at least one coagulation assay (diluted Russell's viper venom time - dRVVT or activated partial thromboplastin time - aPTT), which normalises after addition of phospholipids. Both assays may be influenced by anticoagulants and therefore LA should not be tested during warfarin or heparin treatment. It has been shown (primarily in vitro) that direct oral anticoagulants (DOACs - dabigatran [DAB], rivaroxaban [RIV] and apixaban [API]) may also influence LA testing...
June 22, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28638392/evaluation-of-borage-extracts-as-potential-biostimulant-using-a-phenomic-agronomic-physiological-and-biochemical-approach
#11
Roberta Bulgari, Silvia Morgutti, Giacomo Cocetta, Noemi Negrini, Stefano Farris, Aldo Calcante, Anna Spinardi, Enrico Ferrari, Ilaria Mignani, Roberto Oberti, Antonio Ferrante
Biostimulants are substances able to improve water and nutrient use efficiency and counteract stress factors by enhancing primary and secondary metabolism. Premise of the work was to exploit raw extracts from leaves (LE) or flowers (FE) of Borago officinalis L., to enhance yield and quality of Lactuca sativa 'Longifolia,' and to set up a protocol to assess their effects. To this aim, an integrated study on agronomic, physiological and biochemical aspects, including also a phenomic approach, has been adopted...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28638301/toxic-and-essential-trace-element-content-of-commonly-administered-pediatric-oral-medications
#12
Robert A Yokel, Sarah E Seger, Jason M Unrine
OBJECTIVES: The aim of this study was to test the hypothesis that commonly administered pediatric oral medications are a significant source of toxic elements. The concentrations of 16 elements were determined in 14 frequently used pediatric oral medications. METHODS: Samples were prepared for analysis by dilution or nitric acid microwave-assisted digestion and analyzed by inductively coupled plasma mass spectrometry. The intake of each element from administration for 1 week of the medication's maximum recommended daily dose to 6-month-olds was calculated and compared to an exposure guideline for that element...
May 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28637417/effect-of-heteropterys-aphrodisiaca-on-anxiety-and-male-exposure-of-female-mice-with-advanced-age
#13
Daniela Miranda Farias, Maria Silvia Ostetto, Rozimeri Colleti, Thais Barbosa, Jorge Aparecido Barros, Sergio Machado, Eric Murillo-Rodríguez, Susana E Moreno, André Barciela Veras
BACKGROUND: Effect of Heteropterys aphrodisiac (dog-node) on anxiety and function Of adult female wistar mice. The Project is an experiment with the use of Of H. aphrodisiac root extract, in order to observe the frequency of Sexual exposure of females exposed to the extract, quantify the effect of the extract on the Concentration of total testosterone and observe the anxiety levels of the animals Exposed. Results will be measured with the laboratory testosterone test and LCE and CA tests...
June 21, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28636165/a-feasibility-and-safety-study-of-intracoronary-hemodilution-during-primary-coronary-angioplasty-in-order-to-reduce-reperfusion-injury-in-myocardial-infarction
#14
Michael McGarvey, Omar Ali, M Bilal Iqbal, Charles Ilsley, Joyce Wong, Carlo Di Mario, Simon Redwood, Tiffany Patterson, Dudley J Pennell, Paula Rogers, Miles Dalby
OBJECTIVES: We designed a pilot study to evaluate safety and feasibility of an inexpensive and simple approach to intracoronary hemodilution during primary angioplasty (PPCI) to reduce reperfusion injury. INTRODUCTION: Early revascularization in acute myocardial infarction decreases infarct size and improves outcomes. However, abrupt restoration of coronary flow results in myocardial reperfusion injury and increased final infarct size. Dilution of coronary blood during revascularization may help reduce this damage...
June 21, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28636032/reline-aqueous-solutions-behaving-as-liquid-mixtures-of-h-bonded-co-solvents-microphase-segregation-and-formation-of-co-continuous-structures-as-indicated-by-brillouin-and-1-h-nmr-spectroscopies
#15
E Posada, N López-Salas, R J Jiménez Riobóo, M L Ferrer, M C Gutiérrez, F Del Monte
Deep eutectic solvents (DESs) offer a suitable alternative to conventional solvents in terms of both performance and cost-effectiveness. Some DESs also offer certain green features, the greenness of which is notoriously enhanced when combined with water. Aqueous DES dilutions are therefore attracting great attention as a novel green medium for biotechnological processes, with the aqueous dilutions of reline - a DES composed of urea and choline chloride - being one of the most studied systems. Despite their macroscopic homogeneous appearance, both (1)H NMR spectroscopic studies and molecular dynamics simulations have revealed the occurrence of certain dynamic heterogeneity at a microscopic molecular level...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28635414/core-shell-pla-pva-porous-microparticles-as-carriers-for-bacteriocin-nisin
#16
Pavlina Holcapkova, Martina Hrabalikova, Petra Stoplova, Vladimir Sedlarik
This work is focused on preparation of novel porous type of core-shell-structured microparticles based on polylactide (shell) and poly(vinyl alcohol) cross-linked with glutaric acid (GA) (core) prepared by water-in-oil-in-water solvent evaporation technique. The microparticle systems were used as delivery systems for immobilisation of model antibacterial agent - nisin. The effect of cross-linking and the initial amount of nisin on their morphology was investigated using scanning electron microscopy, BET analysis, zeta potential measurement and Fourier transform infra-red spectroscopy...
June 21, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28635284/competing-stereocomplexation-and-homocrystallization-of-poly-l-lactic-acid-poly-d-lactic-acid-racemic-mixture-effects-of-miscible-blending-with-other-polymer
#17
Jianna Bao, Xiaojia Xue, Kai Li, Xiaohua Chang, Qing Xie, Chengtao Yu, Pengju Pan
Promoting the stereocomplexation ability of high-molecular-weight poly(L-lactic acid) (PLLA) and poly(D-lactic acid) (PDLA) is an efficient way to improve the thermal resistance of resulted materials. Herein, we studied the competing crystallization kinetics, polymorphic crystalline structure, and lamellae structure of PLLA/PDLA component in its miscible blends with poly(vinyl acetate) (PVAc) and proposed a method to improve the stereocomplexation ability of PLLA and PDLA through miscible blending with the other polymer...
June 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28633632/antagonizing-mir-455-3p-inhibits-chemoresistance-and-aggressiveness-in-esophageal-squamous-cell-carcinoma
#18
Aibin Liu, Jinrong Zhu, Geyan Wu, Lixue Cao, Zhanyao Tan, Shuxia Zhang, Lili Jiang, Jueheng Wu, Mengfeng Li, Libing Song, Jun Li
BACKGROUND: The plasticity of cancer stem cells (CSCs)/tumor-initiating cells (T-ICs) suggests that multiple CSC/T-IC subpopulations exist within a tumor and that multiple oncogenic pathways collaborate to maintain the CSC/T-IC state. Here, we aimed to identify potential therapeutic targets that concomitantly regulate multiple T-IC subpopulations and CSC/T-IC-associated pathways. METHODS: A chemoresistant patient-derived xenograft (PDX) model of human esophageal squamous cell carcinoma (ESCC) was employed to identify microRNAs that contribute to ESCC aggressiveness...
June 21, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28632435/relative-effects-of-plasma-fibrinogen-concentrate-and-factor-xiii-on-rotem-coagulation-profiles-in-an-in-vitro-model-of-massive-transfusion-in-trauma
#19
David E Schmidt, Märit Halmin, Agneta Wikman, Anders Östlund, Anna Ågren
Massive traumatic haemorrhage is aggravated through the development of trauma-induced coagulopathy, which is managed by plasma transfusion and/or fibrinogen concentrate administration. It is yet unclear whether these treatments are equally potent in ensuring adequate haemostasis, and whether additional factor XIII (FXIII) administration provides further benefits. In this study, we compared ROTEM whole blood coagulation profiles after experimental massive transfusion with different transfusion regimens in an in vitro model of dilution- and transfusion-related coagulopathy...
June 20, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28631476/room-temperature-rutile-tio2-nanoparticle-formation-on-protonated-layered-titanate-for-high-performance-heterojunction-creation
#20
Kanji Saito, Satoshi Tominaka, Shun Yoshihara, Koji Ohara, Yoshiyuki Sugahara, Yusuke Ide
We report a methodology for creating protonated layered titanate-rutile heterojunctions on the outer particle surface of protonated layered titanate by treating layered potassium titanate (K0.8Ti1.73Li0.27O4) with dilute HCl and then drying it at room temperature under reduced pressure. After Pt co-catalyst-loading, these protonated layered titanate-rutile heterojunctions showed higher photocatalytic H2 evolution activity from water under simulated solar light compared to that of Pt-loaded P25, the standard photocatalyst for this reaction...
June 20, 2017: ACS Applied Materials & Interfaces
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