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https://www.readbyqxmd.com/read/29053620/self-nanoemulsifying-drug-delivery-systems-containing-plantago-lanceolata-an-assessment-of-their-antioxidant-and-antiinflammatory-effects
#1
Azin Kalantari, Dóra Kósa, Dániel Nemes, Zoltán Ujhelyi, Pálma Fehér, Miklós Vecsernyés, Judit Váradi, Ferenc Fenyvesi, Ákos Kuki, Sándor Gonda, Gábor Vasas, Rudolf Gesztelyi, Anayatollah Salimi, Ildikó Bácskay
The most important components of Plantago lanceolata L. leaves are catalpol, aucubin, and acteoside (=verbascoside). These bioactive compounds possess different pharmacological effects: anti-inflammatory, antioxidant, antineoplastic, and hepatoprotective. The aim of this study was to protect Plantago lanceolata extract from hydrolysis and to improve its antioxidant effect using self-nano-emulsifying drug delivery systems (SNEDDS). Eight SNEDDS compositions were prepared, and their physical properties, in vitro cytotoxicity, and in vivo AST/ALT values were investigated...
October 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29053347/phytotoxicity-of-tin-mine-waste-and-accumulation-of-involved-heavy-metals-in-common-buckwheat-fagopyrum-esculentum-moench
#2
Jürgen Franzaring, Walter Damsohn, Andreas Fangmeier, Sonja Schlosser, Hannes Kurz, Philipp Büttner
Extraction and processing of cassiterite (SnO2) left large tailings with high concentrations of tin, tungsten, molybdenum and lithium. Information on the phytotoxicity of mine waste is important with regard to ecological hazards. Exposure studies help to identify plants useful for the stabilization of waste tips and the phytomining of metals. A greenhouse study was performed using a dilution series of mine waste and four crops, a halophytic and a metallophytic species to derive dose response curves. Based on effective doses for growth reductions, sensitivity increased in the following order: maize > common buckwheat > quinoa > garden bean...
October 20, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/29051434/comparative-analysis-between-ecotoxicity-of-nitrogen-phosphorus-and-potassium-based-fertilizers-and-their-active-ingredients
#3
Nathan de Castro Soares Simplício, Daphne Heloísa de Freitas Muniz, Fernanda Regina Moreira Rocha, Denis Cavalcanti Martins, Zélia Malena Barreira Dias, Bruno Pereira da Costa Farias, Eduardo Cyrino Oliveira-Filho
This study aimed to analyze the ecotoxicity of nitrogen-, phosphorus-, and potassium-based compounds to organisms of two different trophic levels in order to compare the toxic effect between high-purity substances and these substances as components of fertilizers. Dilutions were made with the fertilizers' potassium chloride, potassium nitrate, superphosphate, urea, and their equivalent reagents, to conduct assays to establish the acute lethal concentration for half of the population (LC50). Ten individuals of the benthic snail Biomphalaria glabrata and the fish Danio rerio were exposed to each concentration of tested compounds...
December 27, 2016: Toxics
https://www.readbyqxmd.com/read/29049867/ion-pair-and-solvation-dynamics-of-bmim-bf4-water-system
#4
João Cascão, Wagner Silva, Ana S D Ferreira, Eurico J Cabrita
In this work, [Bmim][BF4 ]/water mixtures were analysed over the whole water composition (xw ) in order to study the rotational and translational behaviour of the ions. We employed a multinuclear NMR approach to determine anion/cation/water diffusion coefficients and longitudinal relaxation rates at different water content. In neat IL the cation diffuses faster than the anion and at low xw anions and cations share almost the same diffusion coefficient, but above a critical water concentration the anion begins to diffuse faster than the cation...
October 19, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29049032/large-scale-calculations-of-thermoelectric-transport-coefficients-a-case-study-of-%C3%AE-graphyne-with-point-defects
#5
Jinghua Liang, Huijun Liu, Dengdong Fan, Peiheng Jiang
Defects such as vacancies and impurities could have profound effects on the transport properties of thermoelectric materials. However, it is usually quite difficult to directly calculate the thermoelectric properties of defect-containing systems via first-principles methods since a very large supercell is required. In this work, based on the linear response theory and the kernel polynomial method, we present an efficient approach that can help to calculate the thermoelectric transport coefficients of a large system containing millions of atoms at arbitrary chemical potential and temperature...
October 19, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29048999/structural-distortions-due-to-missense-mutations-in-human-formylglycine-generating-enzyme-leading-to-multiple-sulfatase-deficiency
#6
D Meshach Paul, Tania Chadah, B Senthilkumar, Rao Sethumadhavan, R Rajasekaran
The major candidate for multiple sulfatase deficiency is defective formylglycine-generating enzyme (FGE). Though adequately produced, mutations in FGE stall the activation of sulfatases and prevent their activity. Missense mutations viz., E130D, S155P, A177P, W179S, C218Y, R224W, N259I, P266L, A279V, C336R, R345C, A348P, R349Q and R349W associated with multiple sulfatase deficiency are yet to be computationally studied. Aforementioned mutants were initially screened through ws-SNPs&GO(3D) program. Mutant R345C acquired the highest score and hence was studied in detail...
October 19, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29048844/-determination-of-microcystins-in-algal-bloom-samples-by-ultra-performance-liquid-chromatography-tandem-mass-spectrometry-and-elimination-of-their-matrix-effects
#7
Fei Shen, Yanjuan Xu, Sheng Jiang, Bin Zhao, Junzhe Shi, Jing Chen
A rapid and simple method was commonly used for the determination of microcystins by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The reliability, accuracy and sensitivity of LC-MS/MS determination were affected by the matrix effect because of the complex matrices in algal bloom samples. In this study, the matrix interference and matrix effect problems were effectively reduced or eliminated by diluting samples, optimizing gradient elution programs, and reducing injection volumes...
July 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048704/hydroxyapatite-decreases-cytotoxicity-of-a-glass-ionomer-cement-by-calcium-fluoride-uptake-in-vitro
#8
Casiano Del Angel-Mosqueda, Rene Hernandez-Delgadillo, Osvelia E Rodríguez-Luis, María T Ramírez-Rodríguez, Silvia Munguía-Moreno, Norma V Zavala-Alonso, Juan M Solís-Soto, María A A Nakagoshi-Cepeda, Rosa I Sánchez-Nájera, Sergio E Nakagoshi-Cepeda, Claudio Cabral-Romero
BACKGROUND: Glass ionomer cements (GICs) are widely used in dentistry because of their remineralizing and cariostatic potential induced by fluoride. In vitro studies have reported cell toxicity triggered by GICs; however, the influence of hydroxyapatite (HAp) must be considered. The aim of this study was to evaluate the effect of HAp in decreasing the cytotoxicity of the GIC 3M Vitrebond in vitro. METHODS: Samples of 3M Vitrebond (powder, liquid and light-cured) were incubated in Dulbecco's modified Eagle's medium-Ham's F12 (DMEM-F12) for 24 hours at 37°C...
October 14, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/29048161/effects-of-temperature-and-concentration-on-the-rate-of-photo-bleaching-of-erythrosine-in-water
#9
Joshua K G Karlsson, Owen J Woodford, Roza A S Al-Aqar, Anthony Harriman
Erythrosine, a popular food dye, undergoes fast O2-sensitive bleaching in water when subjected to visible light illumi-nation. In dilute solution, Erythrosine undergoes photo-bleaching via first-order kinetics, where the rate of bleaching depends critically on the rate of photon absorption and on the concentration of dissolved oxygen. Kinetic studies indi-cate that this inherent bleaching is augmented by self-catalysis at higher concentrations of Erythrosine and on long exposure times. Under the conditions used, bleaching occurs by way of geminate attack of singlet molecular oxygen on the chromophore...
October 19, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29047297/inhibition-of-the-solid-state-transformation-of-carbamazepine-in-aqueous-solution-impact-of-polymeric-properties
#10
Alan D Gift, Jacob A Hettenbaugh, Rachel A Quandahl, Madison Mapes
The effects of polymers on the anhydrate-to-hydrate transformation of carbamazepine (CBZ) was investigated. The three types of polymers studied were polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA) and substituted celluloses which included hydroxypropyl methylcellulose (HPMC) and methylcellulose (MC). Anhydrous CBZ was added to dilute aqueous polymer solutions and Raman spectroscopy measurements were collected to monitor the kinetics of the solution-mediated transformation to CBZ dihydrate. Polymers exhibiting the greatest inhibition were able to reduce the growth phase of the solvent mediated transformation and change the habit of the hydrate crystal indicating polymer adsorption to the hydrate crystal surface as the mechanism of inhibition...
October 19, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29046374/a-multivariate-test-of-disease-risk-reveals-conditions-leading-to-disease-amplification
#11
Fletcher W Halliday, Robert W Heckman, Peter A Wilfahrt, Charles E Mitchell
Theory predicts that increasing biodiversity will dilute the risk of infectious diseases under certain conditions and will amplify disease risk under others. Yet, few empirical studies demonstrate amplification. This contrast may occur because few studies have considered the multivariate nature of disease risk, which includes richness and abundance of parasites with different transmission modes. By combining a multivariate statistical model developed for biodiversity-ecosystem-multifunctionality with an extensive field manipulation of host (plant) richness, composition and resource supply to hosts, we reveal that (i) host richness alone could not explain most changes in disease risk, and (ii) shifting host composition allowed disease amplification, depending on parasite transmission mode...
October 25, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29046330/systematic-review-and-metaanalysis-comparing-the-bias-and-accuracy-of-the-modification-of-diet-in-renal-disease-and-chronic-kidney-disease-epidemiology-collaboration-equations-in-community-based-populations
#12
REVIEW
Emily C McFadden, Jennifer A Hirst, Jan Y Verbakel, Julie H McLellan J, F D Richard Hobbs, Richard J Stevens, Chris A O'Callaghan, Daniel S Lasserson
BACKGROUND: The majority of patients with chronic kidney disease are diagnosed and monitored in primary care. Glomerular filtration rate (GFR) is a key marker of renal function, but direct measurement is invasive; in routine practice, equations are used for estimated GFR (eGFR) from serum creatinine. We systematically assessed bias and accuracy of commonly used eGFR equations in populations relevant to primary care. CONTENT: MEDLINE, EMBASE, and the Cochrane Library were searched for studies comparing measured GFR (mGFR) with eGFR in adult populations comparable to primary care and reporting both the Modification of Diet in Renal Disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations based on standardized creatinine measurements...
October 18, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29045875/the-effect-of-solutes-on-the-temperature-of-miscibility-transitions-in-multicomponent-membranes
#13
David W Allender, M Schick
We address questions posed by experiments that show small-chain alcohols reduce the miscibility transition temperature when added to giant plasma membrane vesicles (GPMVs), but increase that temperature when added to giant unilamellar vesicles. In giant unilamellar vesicles the change in temperature displays a definite minimum, between decanol and tetradecanol, as a function of alcohol chain length; in GPMVs there is no such minimum. To emphasize the competition between internal entropies of the components and the interactions between them, we model the system as consisting of three different linear polymers...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29045472/sulfites-inhibit-the-growth-of-four-species-of-beneficial-gut-bacteria-at-concentrations-regarded-as-safe-for-food
#14
Sally V Irwin, Peter Fisher, Emily Graham, Ashley Malek, Adriel Robidoux
Sulfites and other preservatives are considered food additives to limit bacterial contamination, and are generally regarded as safe for consumption by governmental regulatory agencies at concentrations up to 5000 parts per million (ppm). Consumption of bactericidal and bacteriostatic drugs have been shown to damage beneficial bacteria in the human gut and this damage has been associated with several diseases. In the present study, bactericidal and bacteriostatic effects of two common food preservatives, sodium bisulfite and sodium sulfite, were tested on four known beneficial bacterial species common as probiotics and members of the human gut microbiota...
2017: PloS One
https://www.readbyqxmd.com/read/29043250/canine-food-preference-assessment-of-animal-and-vegetable-ingredient-based-diets-using-single-pan-tests-and-behavioral-observation
#15
Meghan C Callon, Cara Cargo-Froom, Trevor J DeVries, Anna K Shoveller
Knowledge of canine food selection is critical for both the pet food industry and dog owners, since owners want quality foods that are palatable, while fulfilling their pet's nutritional requirements. There are two common methods for assessing canine food preference: the two-pan test and the one-pan test. Neither test fully accounts for the complexity of the canine feeding experience nor do they provide applicable representations of canine feeding behavior in the home. The objectives of this study were to (1) determine whether dogs display a preference for animal ingredient-based diets when compared with vegetable ingredient-based diets and (2) examine whether dogs experience neophobia when presented with a novel diet...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29042921/protective-effects-of-ellagic-acid-against-tetrachloride-induced-cirrhosis-in-mice-through-the-inhibition-of-reactive-oxygen-species-formation-and-angiogenesis
#16
Yuan Ding, Lizhou Wang, Jie Song, Shi Zhou
Ellagic acid has been proven to have anticancer, antimutation, antimicrobial and antiviral functions. The present study investigated whether treatment with ellagic acid was able to prevent tetrachloride (CCl4)-induced cirrhosis through the inhibition of reactive oxygen species (ROS) formation and angiogenesis. CCl4 diluted in olive oil at a final concentration of 10% was used to induce a cirrhosis model. A total of 40 mice were random allocated into four groups, as follows: Control, cirrhosis model, 7.5 mg/kg ellagic acid and 15 mg/kg ellagic acid groups...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042725/the-effect-of-polymerization-and-preparation-techniques-on-the-microleakage-of-composite-laminate-veneers
#17
Neslihan Celik, Merve Iscan Yapar, Numan Taşpınar, Nilgun Seven
BACKGROUND: Marginal leakage is the important factor influencing the maintenance of dental esthetic. AIM: The purpose of this study was to evaluate the relationship between the preparation techniques and type of polymerization techniques on microleakage of composite laminate veneers. MATERIALS AND METHODS: Ninety-one same sized, caries-free human maxillary central incisors were randomly assigned to 13 groups (n = 7) and were designed with four different preparation techniques (window type, feather type, bevel type, and incisal overlap type)...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29042666/equation-of-state-and-self-bound-droplet-in-rabi-coupled-bose-mixtures
#18
Alberto Cappellaro, Tommaso Macrì, Giovanni F Bertacco, Luca Salasnich
Laser induced transitions between internal states of atoms have been playing a fundamental role to manipulate atomic clouds for many decades. In absence of interactions each atom behaves independently and their coherent quantum dynamics is described by the Rabi model. Since the experimental observation of Bose condensation in dilute gases, static and dynamical properties of multicomponent quantum gases have been extensively investigated. Moreover, at very low temperatures quantum fluctuations crucially affect the equation of state of many-body systems...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038939/effect-of-cobalt-on-sperm-motility-in-an-endangered-trout-species-salmo-coruhensis
#19
Mehmet Kocabaş, Filiz Kutluyer
Experiments were designed to examine the in vitro effect of cobalt on sperm motility of the endangered trout species (Salmo coruhensis). Sperm samples were diluted in an immobilizing solution, and activated in a motility-activation solution that was supplemented with cobalt at concentrations of 1, 10, 100 and 1000 mg/L. The percentage of motile sperm and duration of motility were determined. Cobalt concentrations of 1-100 mg/L had a positive effect on the percentage of motile sperm and duration of motility compared to the control group, while a concentration of 1000 mg/L resulted in decreases in these parameters (p < 0...
October 16, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29038277/dilution-factor-of-quantitative-bacterial-cultures-obtained-by-bronchoalveolar-lavage-in-patients-with-ventilator-associated-bacterial-pneumonia-implications-for-optimal-antimicrobial-therapy-ventilator-associated-bacterial-pneumonia-study-group
#20
George L Drusano, Michael L Corrado, Gino Girardi, Evelyn J Ellis-Grosse, Richard G Wunderink, Helen Donnelly, Kenneth V Leeper, Mona Brown, Tasnova Malek, Robert Duncan Hite, Michelle Ferrari, Danijela Djureinovic, Marin H Kollef, Lisa Mayfield, Ann Doyle, Jean Chastre, Alain Combes, Thomas J Walsh, Krisztina Dorizas, Hassan Alnuaimat, Brooks Edward Morgan, Jordi Rello, Cristopher Alan Mazo Torre, Ronald N Jones, Robert K Flamm, Leah Woosley, Paul G Ambrose, Sujata Bhavnani, Christopher M Rubino, Catharine C Bulik, Arnold Louie, Michael Vicchiarelli, Colleen Berman
Ventilator-Associated Bacterial Pneumonia (VABP) is a difficult therapeutic problem. Considerable controversy exists regarding the optimal chemotherapy for this entity. The recent IDSA/ATS guidelines recommended a 7-day therapeutic course for VABP based on the balance of no negative impact on all-cause mortality, less resistance emergence and fewer antibiotic days counterbalanced with a higher relapse rate for patients whose pathogen is a non-fermenter. The bacterial burden causing an infection will have a substantial impact on treatment outcome and resistance selection...
October 16, 2017: Antimicrobial Agents and Chemotherapy
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