Estefania Viano, Natalia S Baez, Constanza Savid-Frontera, Eliana Baigorrí, Brenda Dinatale, Maria Florencia Pacini, Camila Bulfoni Balbi, Florencia Belén Gonzalez, Laura Fozzatti, Nicolas L Lidón, Howard A Young, Deborah Hodge, Fabio Cerban, Cinthia Stempin, Ana Rosa Pérez, Maria Cecilia Rodriguez Galán
The thymus plays a crucial role in T cell differentiation, a complex process influenced by various factors such as antigens, the microenvironment and thymic architecture. The way the thymus resolves infections is critical, as chronic persistence of microbes or inflammatory mediators can obstruct the differentiation. Here, we illustrate that following inflammatory T helper 1 infectious processes like those caused by C. albicans or T. cruzi, single positive thymocytes adopt a mature phenotype. Further investigations focused on T...
April 12, 2024: Microbes and Infection