keyword
MENU ▼
Read by QxMD icon Read
search

Medullary

keyword
https://www.readbyqxmd.com/read/29031027/evaluation-of-renal-perfusion-in-hyperthyroid-cats-before-and-after-radioiodine-treatment
#1
E Stock, S Daminet, D Paepe, E Buresova, E Vandermeulen, P Smets, L Duchateau, J H Saunders, K Vanderperren
BACKGROUND: Hyperthyroidism and chronic kidney disease (CKD) are common in elderly cats. Consequently, both diseases often occur concurrently. Furthermore, renal function is affected by thyroid status. Because changes in renal perfusion play an important role in functional renal changes in hyperthyroid cats, investigation of renal perfusion may provide novel insights. OBJECTIVES: To evaluate renal perfusion in hyperthyroid cats with contrast-enhanced ultrasound (CEUS)...
October 14, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29027612/penetrance-of-a-rare-familial-mutation-predisposing-to-papillary-thyroid-cancer
#2
Donika Saporito, Pamela Brock, Heather Hampel, Jennifer Sipos, Soledad Fernandez, Sandya Liyanarachchi, Albert de la Chapelle, Rebecca Nagy
Familial non-medullary thyroid cancer (FNMTC) is clinically defined as two or more first-degree relatives with NMTC and appears to follow an autosomal dominant inheritance pattern. Approximately 5-7% of NMTC is hereditary and affects multiple generations with a young age of onset. The primary aim of this study was to determine the age-specific penetrance of NMTC in individuals from a large family with FNMTC with a previously identified private mutation at 4q32, with a secondary aim to determine the penetrance for benign thyroid disease in this family...
October 12, 2017: Familial Cancer
https://www.readbyqxmd.com/read/29027577/assessment-of-renal-perfusion-impairment-in-a-rat-model-of-acute-renal-congestion-using-contrast-enhanced-ultrasonography
#3
Kaoru Komuro, Yoshihiro Seo, Masayoshi Yamamoto, Seika Sai, Tomoko Ishizu, Kyo Shimazu, Yumi Takahashi, Shogo Imagawa, Teisuke Anzai, Kazuya Yonezawa, Kazutaka Aonuma
Renal congestion is caused by elevated central venous pressure (CVP), and decreases glomerular filtration in patients with congestive heart failure. Since real-time contrast-enhanced ultrasonography (CEUS) using microbubble-based contrast agents can visualize the perfused microvascular bed, we sought to evaluate the impairment of renal perfusion during acute renal congestion with CEUS. In Wister rats, CEUS of kidney was performed with the direct monitoring of CVP and intra-renal pressure (IRP). When CVP was elevated to 10 and 15 mmHg after the bolus injection of normal saline via the femoral vein, peak intensity (PI, dB) and time to PI (TTP) in the renal cortex and medulla were compared with control rats...
October 13, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29026772/lateral-medullary-syndrome-after-a-scorpion-sting
#4
Vineeth Varghese Thomas, Tina George, Ajay Kumar Mishra, Pavithra Mannam, I Ramya
Scorpion bites are a common problem in Southern parts of India. The sting of Mesobuthus tamulus belonging to the Buthidae family is known for being fatal. The toxidrome of scorpion sting is known for its effect on the cardiovascular system, and there have been rare reports of cerebrovascular accidents as well. We describe a case of lateral medullary syndrome secondary to scorpion sting. As per the knowledge of the authors, this is the first case report of the same.
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026670/rare-case-of-conus-medullaris-glioblastoma-multiforme-in-a-teenager
#5
Lakhdar Fayçal, Bougrine Mouna, El Abbadi Najia
BACKGROUND: Primary intramedullary spinal glioblastoma multiforme (GBM) lesions are very rare comprising only 1.5% of all spinal cord tumors. These lesions typically result in rapid neurological deterioration and are associated with a very poor prognosis. CASE DESCRIPTION: A 16-year-old male exhibited a slowly progressive paraparesis with urinary incontinence, ultimately resulting in paraplegia. On magnetic resonance (MR), he was diagnosed with an intramedullary GBM of the spinal cord extending from the T9 level through the conus medullaris...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29026560/uncommon-response-of-cisplatin-and-etoposide-for-treatment-of-advanced-medullary-thyroid-carcinoma
#6
Nathamon Panomuppakarn, Patamintita Witoonpanich, Jariya Waisayarat, Chuleeporn Jiarpinitnun, Touch Ativitavas, Nuttapong Ngamphaiboon
Systemic treatment of Medullary thyroid carcinoma (MTC) is currently limited to the use of a tyrosine kinase inhibitor. Cytotoxic chemotherapy is not routinely recommended in the earlier lines of treatment due to the lack of efficacy. We describe a patient with locally advanced MTC who had an uncommon response to cisplatin and etoposide.
October 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29026467/chromogranin-a-as-a-biochemical-marker-for-neuroendocrine-tumors-a-single-center-experience-at-royal-hospital-oman
#7
Elham S Al-Risi, Fatma S Al-Essry, Waad-Allah S Mula-Abed
OBJECTIVES: To evaluate the significance of serum chromogranin A (CgA) status in patients with and without different neuroendocrine tumors (NETs) by conducting a retrospective assessment of the diagnostic utility and limitations of CgA as a biomarker for NETs in a tertiary care hospital in Oman. METHODS: We conducted a retrospective analysis of CgA requests referred to the Clinical Biochemistry Laboratory, Royal Hospital, Oman over a 24-month period (April 2012 to March 2014)...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29026273/detection-of-early-stage-medullary-thyroid-carcinoma-by-measuring-serum-calcitonin-using-an-electro-chemiluminescence-immuno-assay-a-case-report-of-a-young-japanese-woman-with-a-high-risk-ret-mutation
#8
Yuki Abe, Shinya Tsukano
Medullary thyroid carcinoma (MTC) in multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant disorder caused by the mutation of the RET proto-oncogene, that shows nearly complete penetration. The American Thyroid Association guidelines recommend prophylactic thyroidectomy for patients with high-risk RET mutations. However, in Japan, ethical and medical issues may preclude prophylactic treatment in young patients. Hence, an early diagnosis of MTC is necessary to ensure a favorable outcome. Here, we report the case of a young Japanese girl with a high-risk RET mutation, diagnosed with very early stage MTC using serum calcitonin (Ctn) values measured using an electro chemiluminescence immuno-assay (ECLIA)...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29025986/-18-f-fluorodeoxyglycose-avid-thyroid-incidentalomas-the-importance-of-contextual-interpretation
#9
David A Pattison, Michael Bozin, Alexandra Gorelik, Michael S Hofman, Rodney J Hicks, Anita Skandarajah
Background: FDG-avid thyroid incidentalomas (TI) are seen in approximately 2.5% of patients imaged for staging or response assessment of malignancy and represent thyroid cancer in approximately 35% of cases. Consequently, the 2015 ATA guidelines strongly recommend investigation of all FDG-avid nodules ≥1cm with US and fine needle aspiration cytology (FNA). This study aims to assess the overall and thyroid cancer specific survival in a large cohort of patients with FDG-avid TI with long-term follow-up to assess the validity of this approach...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29025983/predictive-value-of-fdg-pet-in-patients-with-advanced-medullary-thyroid-carcinoma-treated-with-vandetanib
#10
Rudolf A Werner, Jan Stefan Schmid, Takahiro Higuchi, Mehrbod Som Javadi, Steven P Rowe, Bruno Märkl, Christoph Aulmann, Martin Fassnacht, Matthias Kroiss, Christoph Reiners, Andreas K Buck, Michael Kreissl, Constantin Lapa
Introduction: Therapeutic options in advanced medullary thyroid carcinoma (MTC) have markedly improved since the introduction of tyrosine kinase inhibitors (TKI). We aimed to assess the role of metabolic imaging using 2-deoxy-2-((18)F)fluoro-D-glucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) shortly before and 3 months after initiation of TKI treatment. Methods: Eighteen patients with advanced and progressive MTC scheduled for vandetanib treatment underwent baseline (18)F-FDG PET/CT prior to and 3 months after TKI treatment initiation...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29022503/the-renal-outer-medullary-potassium-channel-romk-an-intriguing-pharmacological-target-for-an-innovative-class-of-diuretic-drugs
#11
Vincenzo Calderone, Alma Martelli, Eugenia Piragine, Valentina Citi, Lara Testai, Maria Cristina Breschi
In the last four decades, the several classes of diuretics, currently available for clinical use, have been the first line option for the therapy of widespread cardiovascular and non-cardiovascular diseases. Diuretic drugs generally exhibit an overall favourable risk/benefit balance. However, they are not devoid of side effects. In particular, all the classes of diuretics cause alteration of potassium homeostasis. In recent years, understanding of the physiological role of the renal outer medullary potassium (ROMK) channels, has shown an intriguing pharmacological target for developing an innovative class of diuretic agents: the ROMK inhibitors...
October 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29022190/in-vivo-study-of-a-bioactive-nanoparticle-gelatin-composite-scaffold-for-bone-defect-repair-in-rabbits
#12
Guojin Hou, Fang Zhou, Yan Guo, Zhongwei Yang, Ailing Li, Chen Wang, Dong Qiu
The purpose is to study the in vivo bioactivity of this scaffold and verify its ability to simulate the characteristics of cancellous bone. Twenty-four adult New Zealand white rabbits were divided into three groups. Bone defects above the femoral condylar of both sides were created. A newly designed bioactive nanoparticle-gelatin composite scaffold was implanted to the experimental side, while the control side was left without implantation. The repair of bone defect was monitored by X-ray examination, gross observation, Micro-CT examination and histological observation of the area of bone defect 4, 8 and 12 weeks after surgery...
October 11, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29021196/nf-%C3%AE%C2%BAb-dependent-upregulation-of-pro-renin-receptor-mediates-high-nacl-induced-apoptosis-in-mouse-inner-medullary-collecting-duct-cells
#13
Jiahui Su, Xiyang Liu, Chuanming Xu, Xiaohan Lu, Fei Wang, Hui Fang, Aihua Lu, Qixiang Qiu, Chunling Li, Tianxin Yang
(Pro)renin receptor (PRR), a new component of renin-angiotensin system (RAS), has emerged as a new regulator of collecting duct function. The present study was designed to investigate the role of PRR in high salt-induced apoptosis in cultured mouse inner medullary collecting duct cells, mIMCD-K2 cells. Exposure to high NaCl at 550 mOsm/kg H2O increased PRR protein abundance so did mannitol, sodium gluconate or choline chloride. This was accompanied with upregulation of phosphorylated NF-κB p65 protein abundance...
October 11, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29018191/d-serine-released-by-astrocytes-in-brainstem-regulates-breathing-response-to-co2-levels
#14
S Beltrán-Castillo, M J Olivares, R A Contreras, G Zúñiga, I Llona, R von Bernhardi, J L Eugenín
Central chemoreception is essential for adjusting breathing to physiological demands, and for maintaining CO2 and pH homeostasis in the brain. CO2-induced ATP release from brainstem astrocytes stimulates breathing. NMDA receptor (NMDAR) antagonism reduces the CO2-induced hyperventilation by unknown mechanisms. Here we show that astrocytes in the mouse caudal medullary brainstem can synthesize, store, and release D-serine, an agonist for the glycine-binding site of the NMDAR, in response to elevated CO2 levels...
October 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28993760/monitoring-the-secretory-behavior-of-the-rat-adrenal-medulla-by-high-performance-liquid-chromatography-based-catecholamine-assay-from-slice-supernatants
#15
Frédéric De Nardi, Claudie Lefort, Dimitri Bréard, Pascal Richomme, Christian Legros, Nathalie C Guérineau
Catecholamine (CA) secretion from the adrenal medullary tissue is a key step of the adaptive response triggered by an organism to cope with stress. Whereas molecular and cellular secretory processes have been extensively studied at the single chromaffin cell level, data available for the whole gland level are much scarcer. We tackled this issue in rat by developing an easy to implement experimental strategy combining the adrenal acute slice supernatant collection with a high-performance liquid chromatography-based epinephrine and norepinephrine (NE) assay...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28993517/revisiting-the-road-map-of-medullary-thymic-epithelial-cell-differentiation
#16
Chloé Michel, Corey N Miller, Rita Küchler, Benedikt Brors, Mark S Anderson, Bruno Kyewski, Sheena Pinto
The basic two-step terminal differentiation model of the medullary thymic epithelial cell (mTEC) lineage from immature MHC class II (MHCII)(lo) to mature MHCII(hi) mTECs has recently been extended to include a third stage, namely the post-Aire MHCII(lo) subset as identified by lineage-tracing models. However, a suitable surface marker distinguishing the phenotypically overlapping pre- from the post-Aire MHCII(lo) stage has been lacking. In this study, we introduce the lectin Tetragonolobus purpureas agglutinin (TPA) as a novel cell surface marker that allows for such delineation...
October 9, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28990511/sunitinib-in-the-treatment-of-thyroid-cancer
#17
Ferrari Silvia Martinaa, Centanni Marco, Virili Camilla, Miccoli Mario, Ferrari Paola, Ruffilli Ilaria, Ragusa Francesca, Antonelli Alessandro, Fallahi Poupak
BACKGROUND: Sunitinib (SU11248) is an oral, small-molecule, multi-targeted tyrosine kinase inhibitor (TKI), that inhibits receptors for platelet-derived growth factor (PDGF-Rs) and vascular endothelial growth factor receptors (VEGFRs), c-KIT, fms-related tyrosine kinase 3 (FLT3) and RET. The concurrent inhibition of these pathways reduces tumor vascularization and causes cancer cell apoptosis, inducing a tumor shrinkage. Sunitinib is approved for the treatment of imatinib-resistant gastrointestinal stromal tumor (GIST), renal carcinoma, and pancreatic neuroendocrine tumors...
October 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28990496/bone-marrow-findings-secondary-to-antineoplastic-compounds-hematopoietic-bone-and-cytokine-cross-talk
#18
Lise I Loberg, Michael Logan, Kirstin Barnhart, Stacey Fossey, Katharine Whitney
New medullary bone formation has been observed in rats administered a variety of antineoplastic compounds. Similar effects reported in rats administered granulocyte colony-stimulating factor (G-CSF) were attributed to exaggerated pharmacology of G-CSF as a cytokine and growth factor, resulting in stromal proliferation in addition to the intended hematopoietic effects. Similar phenomena of marrow stromal change are reported among other species in association with various growth factors. Case study summaries of test item-related histopathologic changes in bone marrow, reflecting trabecular and/or endosteal new bone formation, are presented...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28987939/a-hypothalamo-midbrain-medullary-pathway-involved-in-the-inhibition-of-the-respiratory-chemoreflex-response-induced-by-potassium-cyanide-in-rodents
#19
Tabinda Zafar, Charly Brouillard, Laurence Lanfumey, Caroline Sévoz-Couche
Recent studies have demonstrated that a mild stimulation of the dorsomedian nucleus of the hypothalamus (DMH), a defense area, induces the inhibition of the carotid chemoreflex tachypnea. DMH activation reduces the cardiac chemoreflex response via the dorsolateral part of the periaqueductal grey matter (dlPAG) and serotonin receptors (5-HT3 subtype) in the nucleus tractus solitarius (NTS). The objectives of this study were to assess whether dlPAG and subsequent NTS 5-HT3 receptors are involved in chemoreflex tachypnea inhibition during mild activation of the DMH...
October 4, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28987836/successful-surgical-resection-of-spinal-artery-aneurysms-report-of-three-cases
#20
Yanming Ren, Min He, Chao You, Jin Li
BACKGROUND: Spinal artery aneurysms (SAAs) are extremely rare lesions that can occur in isolation or associated with vascular malformations. Herein, we present three unusual cases of SAAs, and discuss imaging, diagnosis and surgical management strategies. CASE DESCRIPTION: The first case was a 57-year-old woman who presented with sudden onset of severe headache. Spinal angiography demonstrated an isolated anterior spinal artery (ASA) aneurysm at the level of craniocervical junction...
October 4, 2017: World Neurosurgery
keyword
keyword
87986
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"