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https://www.readbyqxmd.com/read/29033806/is-congenital-amusia-a-disconnection-syndrome-a-study-combining-tract-and-network-based-analysis
#1
Jieqiong Wang, Caicai Zhang, Shibiao Wan, Gang Peng
Previous studies on congenital amusia mainly focused on the impaired fronto-temporal pathway. It is possible that neural pathways of amusia patients on a larger scale are affected. In this study, we investigated changes in structural connections by applying both tract-based and network-based analysis to DTI data of 12 subjects with congenital amusia and 20 demographic-matched normal controls. TBSS (tract-based spatial statistics) was used to detect microstructural changes. The results showed that amusics had higher diffusivity indices in the corpus callosum, the right inferior/superior longitudinal fasciculus, and the right inferior frontal-occipital fasciculus (IFOF)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29031764/combined-resting-state-functional-magnetic-resonance-imaging-and-diffusion-tensor-imaging-study-in-patients-with-idiopathic-restless-legs-syndrome
#2
Yaoyao Zhuo, Yuncheng Wu, Yanhong Xu, Lunbo Lu, Ting Li, Xifu Wang, Kangan Li
OBJECTIVE: Restless legs syndrome (RLS) is a common neurological disorder characterized by an urge to move the legs along with paraesthesia deep within them. In this study, we aimed to use diffusion tensor imaging (DTI) and regional homogeneity (ReHo) to investigate the changes in regional spontaneous brain activity change for RLS patients against age- and gender-matched normal control (NC) subjects. METHODS: A total of 35 RLS patients and 27 age- and gender-matched NC subjects were recruited for group comparison research that used DTI and ReHo techniques...
October 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28984377/age-and-sex-related-effects-in-children-with-mild-traumatic-brain-injury-on-diffusion-magnetic-resonance-imaging-properties-a-comparison-of-voxelwise-and-tractography-methods
#3
Naomi J Goodrich-Hunsaker, Tracy J Abildskov, Garrett Black, Erin D Bigler, Daniel M Cohen, Leslie K Mihalov, Barbara A Bangert, H Gerry Taylor, Keith O Yeates
Although there are several techniques to analyze diffusion-weighted imaging, any technique must be sufficiently sensitive to detect clinical abnormalities. This is especially critical in disorders like mild traumatic brain injury (mTBI), where pathology is likely to be subtle. mTBI represents a major public health concern, especially for youth under 15 years of age. However, the developmental period from birth to 18 years is also a time of tremendous brain changes. Therefore, it is important to establish the degree of age- and sex-related differences...
October 6, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28970540/microstructural-network-alterations-of-olfactory-dysfunction-in-newly-diagnosed-parkinson-s-disease
#4
Ming-Ching Wen, Zheyu Xu, Zhonghao Lu, Ling Ling Chan, Eng King Tan, Louis C S Tan
Olfactory dysfunction is a robust and early sign for Parkinson's disease (PD). Previous studies have revealed its association with dementia and related neural changes in PD. Yet, how olfactory dysfunction affects white matter (WM) microstructure in newly diagnosed and untreated PD remains unclear. Here we comprehensively examined WM features using unbiased whole-brain analyses. 88 newly diagnosed PD patients without dementia (70 with hyposmia and 18 without hyposmia) and 33 healthy controls underwent clinical assessment and diffusion tensor imaging (DTI) scanning...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28956133/the-effects-of-mild-germinal-matrix-intraventricular-haemorrhage-on-the-developmental-white-matter-microstructure-of-preterm-neonates-a-dti-study
#5
Domenico Tortora, Carola Martinetti, Mariasavina Severino, Sara Uccella, Mariya Malova, Alessandro Parodi, Fabia Brera, Giovanni Morana, Luca Antonio Ramenghi, Andrea Rossi
OBJECTIVES: To evaluate white matter (WM) microstructural changes in preterm neonates (PN) with mild germinal matrix-intraventricular haemorrhage (mGMH-IVH) (grades I and II) and no other associated MRI abnormalities, and correlate them with gestational age (GA) and neurodevelopmental outcome. METHODS: Tract-based spatial-statistics (TBSS) was performed on DTI of 103 patients studied at term-equivalent age, to compare diffusional parameters (fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD)) between mGMH-IVH neonates (24/103) and controls matched by GA at birth and sex...
September 27, 2017: European Radiology
https://www.readbyqxmd.com/read/28948081/sex-specific-effects-of-comt-val158met-polymorphism-on-corpus-callosum-structure-a-whole-brain-diffusion-weighted-imaging-study
#6
Wissam El-Hage, Helen Cléry, Frederic Andersson, Isabelle Filipiak, Michel Thiebaut de Schotten, Benedicte Gohier, Simon Surguladze
BACKGROUND: Genetic polymorphisms play a significant role in determining brain morphology, including white matter structure and may thus influence the development of brain functions. The main objective of this study was to examine the effect of Val158Met (rs4680) polymorphism of Catechol-O-Methyltransferase (COMT) gene on white matter connectivity in healthy adults. METHODS: We used a whole-brain diffusion-weighted imaging method with Tract-Based Spatial Statistics (TBSS) analysis to examine white matter structural integrity in intrinsic brain networks on a sample of healthy subjects (N = 82)...
September 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28927715/microstructural-white-matter-changes-and-their-relation-to-neuropsychological-deficits-in-patients-with-juvenile-myoclonic-epilepsy
#7
Susanne Knake, Christine Roth, Marcus Belke, Jens Sonntag, Tobias Kniess, Soeren Krach, Andreas Jansen, Jens Sommer, Frieder M Paulus, Barbara Carl, Felix Rosenow, Anke M Hermsen, Katja Menzler
OBJECTIVE: Juvenile myoclonic epilepsy (JME) is the most common idiopathic generalized epilepsy syndrome. Neuropsychological, electrophysiological, and neuroimaging studies have led to the hypothesis that JME is related to dysfunction of frontal brain regions and mainly frontal thalamocortical networks. METHODS: We investigated possible microstructural white matter abnormalities of 20 patients with JME as compared with 20 healthy control subjects using diffusion tensor imaging (DTI)...
September 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28922736/reduced-white-matter-integrity-in-borderline-personality-disorder-a-diffusion-tensor-imaging-study
#8
Taiga Ninomiya, Harumi Oshita, Yoshihisa Kawano, Chiharu Goto, Mai Matsuhashi, Koji Masuda, Fuku Takita, Toshihiko Izumi, Ayako Inoue, Haruka Higuma, Masayuki Kanehisa, Jotaro Akiyoshi
BACKGROUND: Borderline personality disorder (BPD) has a pervasive pattern of instability in interpersonal relationships, self-image, and emotions. BPD may be linked to an abnormal brain anatomy, but little is known about possible impairments of the white matter microstructure in BPD or their relationship with impulsivity or risky behaviors. The aims of the present study were to explore the relationship between BPD and diffusion tensor imaging (DTI) parameters and psychological tests. METHODS: We evaluated 35 un-medicated BPD patients in a medication-free state and 50 healthy controls (HCs)...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28918257/pathways-of-the-inferior-frontal-occipital-fasciculus-in-overt-speech-and-reading
#9
Claire Rollans, Kulpreet Cheema, George K Georgiou, Jacqueline Cummine
In this study, we examined the relationship between tractography-based measures of white matter integrity (ex. fractional anisotropy [FA]) from diffusion tensor imaging (DTI) and five reading-related tasks, including rapid automatized naming (RAN) of letters, digits, and objects, and reading of real words and nonwords. Twenty university students with no reported history of reading difficulties were tested on all five tasks and their performance was correlated with diffusion measures extracted through DTI tractography...
November 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28914724/the-role-of-brain-structure-in-predicting-adherence-to-a-physical-activity-regimen
#10
Swathi Gujral, Edward McAuley, Lauren E Oberlin, Arthur F Kramer, Kirk I Erickson
OBJECTIVE: Physical activity is important for maintaining health throughout the lifespan. However, adherence to PA regimens is poor with approximately 50% of older adults terminating activity intervention programs within 6 months. In this study we tested whether gray matter volume and white matter microstructural integrity prior to the initiation of a PA intervention predicts PA adherence. METHODS: 159 adults aged 60-80 years were randomly assigned to a moderate-intensity aerobic walking condition or a non-aerobic stretching and toning condition...
September 13, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28841761/user-independent-diffusion-tensor-imaging-analysis-pipelines-in-a-rat-model-presenting-ventriculomegalia-a-comparison-study
#11
Luis Akakpo, Wyston C Pierre, Chen Jin, Irène Londono, Philippe Pouliot, Gregory A Lodygensky
Automated analysis of diffusion tensor imaging (DTI) data is an appealing way to process large datasets in an unbiased manner. However, automation can sometimes be linked to a lack of interpretability. Two whole-brain, automated and voxelwise methods exist: voxel-based analysis (VBA) and tract-based spatial statistics (TBSS). In VBA, the amount of smoothing has been shown to influence the results. TBSS is free of this step, but a projection procedure is introduced to correct for residual misalignments. This projection assigns the local highest fractional anisotropy (FA) value to the mean FA skeleton, which represents white matter tract centers...
August 25, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28834083/microstructural-white-matter-tract-alteration-in-prader-willi-syndrome-a-diffusion-tensor-imaging-study
#12
Lauren J Rice, Jim Lagopoulos, Michael Brammer, Stewart L Einfeld
Prader-Willi Syndrome (PWS) is a genetic disorder characterized by infantile hypotonia, hyperphagia, hypogonadism, growth hormone deficiency, intellectual disability, and severe emotional and behavioral problems. The brain mechanisms that underpin these disturbances are unknown. Diffusion tensor imaging (DTI) enables in vivo investigation of the microstructural integrity of white matter pathways. To date, only one study has used DTI to examine white matter alterations in PWS. However, that study used selected regions of interest, rather than a whole brain analysis...
September 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28815853/changes-to-white-matter-microstructure-in-transient-ischemic-attack-a-longitudinal-diffusion-tensor-imaging-study
#13
Jennifer K Ferris, Jodi D Edwards, Jennifer A Ma, Lara A Boyd
Transient ischemic attack (TIA) is associated with localized ischemic changes, identifiable by diffusion-weighted imaging. Past research has not considered whether TIA is also associated with diffuse changes to white matter microstructure; further past work has not tracked changes longitudinally. Here we examine whole-brain changes in fractional anisotropy (FA) in individuals with TIA presenting with sensorimotor symptoms. Twenty individuals with a recent (within 30 days) TIA and 12 healthy older adults were recruited...
August 16, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28802959/a-combined-tract-based-spatial-statistics-and-voxel-based-morphometry-study-of-the-first-mri-scan-after-diagnosis-of-amyotrophic-lateral-sclerosis-with-subgroup-analysis
#14
A R Alruwaili, K Pannek, A Coulthard, R Henderson, N D Kurniawan, P McCombe
BACKGROUND AND PURPOSE: This study aims to compare the cortical and subcortical deep gray matter (GM) and white matter (WM) of ALS subjects and controls and to compare ALS subjects with (ALScog) and without (ALSnon-cog) cognitive impairment. MATERIALS AND METHODS: The study was performed in 30 ALS subjects, and 19 healthy controls. Structural T1- and diffusion-weighted MRI data were analyzed using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS)...
August 9, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28791662/combination-antiretroviral-therapy-improves-cognitive-performance-and-functional-connectivity-in-treatment-na%C3%A3-ve-hiv-infected-individuals
#15
Yuchuan Zhuang, Xing Qiu, Lu Wang, Qing Ma, Mark Mapstone, Amneris Luque, Miriam Weber, Madalina Tivarus, Eric Miller, Roberto C Arduino, Jianhui Zhong, Giovanni Schifitto
Our study aimed to investigate the short-term effect of combination antiretroviral therapy (cART) on cognitive performance and functional and structural connectivity and their relationship to plasma levels of antiretroviral (ARV) drugs. Seventeen ARV treatment-naïve HIV-infected individuals (baseline mean CD4 cell count, 479 ± 48 cells/mm(3)) were age matched with 17 HIV-uninfected individuals. All subjects underwent a detailed neurocognitive and functional assessment and magnetic resonance imaging. HIV-infected subjects were scanned before starting cART and 12 weeks after initiation of treatment...
August 8, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28756994/dual-energy-x-ray-absorptiometry-predictors-of-vertebral-deformities-in-beta-thalassemia-major
#16
Giangiacomo Osella, Adriano Massimiliano Priola, Sandro Massimo Priola, Antonio Piga, Filomena Longo, Massimo Ventura, Giuseppe Bentivegna, Alberto Angeli, Andrea Veltri, Massimo Terzolo
Vertebral fractures in beta-thalassemia major are increasingly found because of the longer life expectancy of patients, with a major negative impact on their quality of life. We performed a retrospective cross-sectional study to investigate the prevalence of vertebral deformities in thalassemic patients and to identify their best dual-energy X-ray absorptiometry (DXA) predictor among trabecular bone score (TBS), bone mineral density (BMD), and Z-score. Eighty-two outpatients with beta-thalassemia major on regular conventional treatment were studied at a single academic center...
July 27, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28729077/white-matter-microstructure-degenerates-in-patients-with-postherpetic-neuralgia
#17
Fuxiang Chen, Fuyong Chen, Zhanfang Shang, Yuan Shui, Guorong Wu, Chen Liu, Zhangya Lin, Yuanxiang Lin, Lianghong Yu, Dezhi Kang, Wei Tao, Yongjie Li
OBJECTIVE: The central mechanisms underlying postherpetic neuralgia (PHN) pain remains unknown. The primary purpose of this study was to identify microstructural white matter changes closely related to the PHN pain by means of diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS) analysis. METHODS: DTI data of the brains were obtained from 8 PHN patients and 8 healthy controls (HC) that were matched in age, gender, and educational level. DTI metrics, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD), were separately compared between the two groups using TBSS analysis to detect subtle microstructural changes...
July 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28721394/interhemispheric-disconnectivity-in-the-sensorimotor-network-in-bipolar-disorder-revealed-by-functional-connectivity-and-diffusion-tensor-imaging-analysis
#18
Takuya Ishida, Tomohiro Donishi, Jun Iwatani, Shinichi Yamada, Shun Takahashi, Satoshi Ukai, Kazuhiro Shinosaki, Masaki Terada, Yoshiki Kaneoke
BACKGROUND: Little is known regarding interhemispheric functional connectivity (FC) abnormalities via the corpus callosum in subjects with bipolar disorder (BD), which might be a key pathophysiological basis of emotional processing alterations in BD. METHODS: We performed tract-based spatial statistics (TBSS) using diffusion tensor imaging (DTI) in 24 healthy control (HC) and 22 BD subjects. Next, we analyzed the neural networks with independent component analysis (ICA) in 32HC and 25 BD subjects using resting-state functional magnetic resonance imaging...
June 2017: Heliyon
https://www.readbyqxmd.com/read/28710748/longitudinal-changes-in-white-matter-fractional-anisotropy-in-adult-onset-niemann-pick-disease-type-c-patients-treated-with-miglustat
#19
Elizabeth A Bowman, Dennis Velakoulis, Patricia Desmond, Mark Walterfang
Niemann-Pick disease type C (NPC) is a rare neurometabolic disorder resulting in impaired intracellular lipid trafficking. The only disease-modifying treatment currently available is miglustat, an iminosugar that inhibits the accumulation of lipid metabolites in neurons and other cells. This longitudinal diffusion tensor imaging (DTI) study examined how the rate of white matter change differed between treated and non-treated adult-onset NPC patient groups. Nine adult-onset NPC patients (seven undergoing treatment with miglustat, two not treated) underwent DTI neuroimaging...
July 15, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28709907/the-details-of-structural-disconnectivity-in-psychotic-disorder-a-family-based-study-of-non-fa-diffusion-weighted-imaging-measures
#20
Stijn Michielse, Ed Gronenschild, Patrick Domen, Jim van Os, Machteld Marcelis
BACKGROUND: Diffusion Tensor Imaging (DTI) studies in psychotic disorder have shown reduced FA, often interpreted as disturbed white matter integrity. The observed 'dysintegrity' may be of multifactorial origin, as changes in FA are thought to reflect a combination of changes in myelination, fiber organization and number of axons. Examining the structural substrate of the diffusion tensor in individuals with (risk for) psychotic disorder may provide better understanding of the underlying structural changes...
July 11, 2017: Brain Research
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