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https://www.readbyqxmd.com/read/28336929/developmental-whole-brain-white-matter-alterations-in-transgenic-huntington-s-disease-monkey
#1
Yuguang Meng, Jie Jiang, Jocelyne Bachevalier, Xiaodong Zhang, Anthony W S Chan
Transgenic Huntington's disease monkey (HD monkey) model provides great opportunity for studying disease progression that could lead to new insight for developing biomarker, early intervention and novel therapeutics. Whole brain white matter integrity of HD-monkeys was examined longitudinally from 6 to 48 months using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). Progressive developmental white matter alterations in HD monkeys were widespread and were observed not only in fiber bundles connecting cortical areas to the striatum (e...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28318507/usefulness-of-diffusion-tensor-mri-in-the-diagnosis-of-parkinson-variant-of-multiple-system-atrophy-and-parkinson-s-disease-a-valuable-tool-to-differentiate-between-them
#2
B Chen, G Fan, W Sun, X Shang, S Shi, S Wang, G Lv, C Wu
AIM: To evaluate the differences between patients with Parkinson's disease (PD) and Parkinson variant of multiple system atrophy (MSAp) at fractional anisotropy (FA) in the white matter when using the tract-based spatial statistics (TBSS) algorithm to provide objective markers for a differential diagnosis. MATERIALS AND METHODS: Diffusion-tensor imaging (DTI) data were acquired from 18 PD patients, 20 MSAp patients, and 24 healthy controls using a GE 3 T Signa HDx magnetic resonance imaging (MRI) system...
March 16, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28295280/structural-and-functional-connectivity-in-children-and-adolescents-with-and-without-attention-deficit-hyperactivity-disorder
#3
Dienke J Bos, Bob Oranje, Michelle Achterberg, Chantal Vlaskamp, Sara Ambrosino, Marcel A de Reus, Martijn P van den Heuvel, Serge A R B Rombouts, Sarah Durston
BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) has frequently been associated with changes in resting-state functional connectivity, and decreased white matter (WM) integrity. In the current study, we investigated functional connectivity within Default Mode and frontal control resting-state networks (RSNs) in children with and without ADHD. We hypothesized the RSNs of interest would show a pattern of impaired functional integration and segregation and corresponding changes in WM structure...
March 10, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28294462/disruption-of-white-matter-structural-integrity-and-connectivity-in-posttraumatic-stress-disorder-a-tbss-and-tractography-study
#4
Elizabeth A Olson, Jiaolong Cui, Rena Fukunaga, Lisa D Nickerson, Scott L Rauch, Isabelle M Rosso
BACKGROUND: Most studies of brain white matter (WM) in posttraumatic stress disorder (PTSD) have focused on combat trauma, and often were confounded by neurological and substance dependence comorbidity. This study used tract-based spatial statistics (TBSS) and probabilistic tractography to characterize WM microstructure in a mixed-sex community sample of PTSD patients exposed to diverse and multiple traumas, and in trauma-exposed normal comparison (TENC) subjects. METHODS: TBSS compared diffusion measures between 20 adults with DSM-IV PTSD and 17 TENC, using a whole-brain voxel-wise approach...
March 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28291592/white-matter-and-cortical-changes-in-atypical-parkinsonisms-a-multimodal-quantitative-mr-study
#5
Stefano Zanigni, Stefania Evangelisti, Claudia Testa, David N Manners, Giovanna Calandra-Buonaura, Maria Guarino, Anna Gabellini, Laura Ludovica Gramegna, Giulia Giannini, Luisa Sambati, Pietro Cortelli, Raffaele Lodi, Caterina Tonon
OBJECTIVES: To evaluate white matter and cortical changes in patients with parkinsonisms and healthy controls (HC), applying both hypothesis-free and regions of interest (ROI)-based advanced brain MR analyses. METHODS: Twenty-five patients with Progressive Supranuclear Palsy - Richardson's Syndrome (PSP-RS), nine with cerebellar and nine with parkinsonian Multiple System Atrophy variants (MSA-C and MSA-P), forty-seven with Parkinson's Disease (PD) and twenty-seven HC underwent a 1...
March 6, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28291264/abnormal-white-matter-structural-connectivity-in-adults-with-obsessive-compulsive-disorder
#6
J Gan, M Zhong, J Fan, W Liu, C Niu, S Cai, L Zou, Ya Wang, Yi Wang, C Tan, R C K Chan, X Zhu
Obsessive-compulsive disorder (OCD) is a complex and severe psychiatric disorder whose pathogenesis is not fully understood. Recent studies have shown white matter (WM) alterations in adults with OCD, but the results have been inconsistent. The present study investigated WM structure in OCD patients with the hypothesis that large-scale brain networks may be disrupted in OCD. A total of 24 patients with OCD and 23 healthy controls (HCs) were scanned with diffusion tensor imaging. A tract-based spatial statistics (TBSS) approach was used to detect differences across the whole brain in patients with OCD vs HCs; post hoc fiber tractography was applied to characterize developmental differences between the two groups...
March 14, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28263923/bilingualism-modulates-the-white-matter-structure-of-language-related-pathways
#7
Sini Hämäläinen, Viljami Sairanen, Alina Leminen, Minna Lehtonen
Learning and speaking a second language (L2) may result in profound changes in the human brain. Here, we investigated local structural differences along two language-related white matter trajectories, the arcuate fasciculus and the inferior fronto-occipital fasciculus (IFOF), between early simultaneous bilinguals and late sequential bilinguals. We also examined whether early exposure to two languages might lead to a more bilateral structural organization of the arcuate fasciculus. Fractional anisotropy, mean and radial diffusivities (FA, MD, and RD respectively) were extracted to analyse tract-specific changes...
March 2, 2017: NeuroImage
https://www.readbyqxmd.com/read/28255458/brain-white-matter-impairment-in-patients-with-spinal-cord-injury
#8
Weimin Zheng, Qian Chen, Xin Chen, Lu Wan, Wen Qin, Zhigang Qi, Nan Chen, Kuncheng Li
It remains unknown whether spinal cord injury (SCI) could indirectly impair or reshape the white matter (WM) of human brain and whether these changes are correlated with injury severity, duration, or clinical performance. We choose tract-based spatial statistics (TBSS) to investigate the possible changes in whole-brain white matter integrity and their associations with clinical variables in fifteen patients with SCI. Compared with the healthy controls, the patients exhibited significant decreases in WM fractional anisotropy (FA) in the left angular gyrus (AG), right cerebellum (CB), left precentral gyrus (PreCG), left lateral occipital region (LOC), left superior longitudinal fasciculus (SLF), left supramarginal gyrus (SMG), and left postcentral gyrus (PostCG) (p < 0...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28251596/cocaine-dependence-does-not-contribute-substantially-to-white-matter-abnormalities-in-hiv-infection
#9
Daniella M Cordero, Sheri L Towe, Nan-Kuei Chen, Kevin R Robertson, David J Madden, Scott A Huettel, Christina S Meade
This study investigated the association of HIV infection and cocaine dependence with cerebral white matter integrity using diffusion tensor imaging (DTI). One hundred thirty-five participants stratified by HIV and cocaine status (26 HIV+/COC+, 37 HIV+/COC-, 37 HIV-/COC+, and 35 HIV-/COC-) completed a comprehensive substance abuse assessment, neuropsychological testing, and MRI with DTI. Among HIV+ participants, all were receiving HIV care and 46% had an AIDS diagnosis. All COC+ participants were current users and met criteria for cocaine use disorder...
March 1, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28236715/the-association-of-sleep-and-physical-activity-with-integrity-of-white-matter-microstructure-in-bipolar-disorder-patients-and-healthy-controls
#10
Sanne Verkooijen, Remi Stevelink, Lucija Abramovic, Christiaan H Vinkers, Roel A Ophoff, René S Kahn, Marco P M Boks, Neeltje E M van Haren
We investigate how the sleep disruptions and irregular physical activity levels that are prominent features of bipolar disorder (BD) relate to white matter microstructure in patients and controls. Diffusion tension imaging (DTI) and 14-day actigraphy recordings were obtained in 51 BD I patients and 55 age-and-gender-matched healthy controls. Tract-based spatial statistics (TBSS) was used for voxelwise analysis of the association between fractional anisotropy (FA) and sleep and activity characteristics in the overall sample...
February 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28218643/diffusion-assessment-of-cortical-changes-induced-by-traumatic-spinal-cord-injury
#11
Peng Sun, Rory K J Murphy, Paul Gamble, Ajit George, Sheng-Kwei Song, Wilson Z Ray
Promising treatments are being developed to promote functional recovery after spinal cord injury (SCI). Magnetic resonance imaging, specifically Diffusion Tensor Imaging (DTI) has been shown to non-invasively measure both axonal and myelin integrity following traumatic brain and SCI. A novel data-driven model-selection algorithm known as Diffusion Basis Spectrum Imaging (DBSI) has been proposed to more accurately delineate white matter injury. The objective of this study was to investigate whether DTI/DBSI changes that extend to level of the cerebral peduncle and internal capsule following a SCI could be correlated with clinical function...
February 17, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28205341/spatiotemporal-microstructural-white-matter-changes-in-diffusion-tensor-imaging-after-transient-focal-ischemic-stroke-in-rats
#12
Won-Beom Jung, Yong Hee Han, Julius Juhyun Chung, Sun Young Chae, Sung Hoon Lee, Geun Ho Im, JiHoon Cha, Jung Hee Lee
Structural reorganization in white matter (WM) after stroke is a potential contributor to substitute or to newly establish the functional field on the injured brain in nature. Diffusion tensor imaging (DTI) is an imaging modality that can be used to evaluate damage and recovery within the brain. This method of imaging allows for in vivo assessment of the restricted movements of water molecules in WM and provides a detailed look at structural connectivity in the brain. For longitudinal DTI studies after a stroke, the conventional region of interest method and voxel-based analysis are highly dependent on the user-hypothesis and parameter settings for implementation...
February 16, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28203530/longitudinal-evaluation-of-cerebral-and-spinal-cord-damage-in-amyotrophic-lateral-sclerosis
#13
Milena de Albuquerque, Lucas Melo T Branco, Thiago Junqueira R Rezende, Helen Maia Tavares de Andrade, Anamarli Nucci, Marcondes Cavalcante França
OBJECTIVE: To evaluate MRI-based parameters as biomarkers of Amyotrophic Lateral Sclerosis (ALS) progression. METHODS: Twenty-seven patients and 27 controls performed two clinical and MRI acquisitions 8 months apart. ALSFRS-R scale was used to quantify disease severity at both time points. Multimodal analyses of MRI included cortical thickness measurements (FreeSurfer software), analysis of white matter integrity using diffusion-tensor imaging (tract-based spatial statistics-TBSS) and measurement of cervical spinal cord cross-sectional area (SpineSeg software)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28190639/characterizing-white-matter-changes-in-chronic-schizophrenia-a-free-water-imaging-multi-site-study
#14
Lena K L Oestreich, Amanda E Lyall, Ofer Pasternak, Zora Kikinis, Dominick T Newell, Peter Savadjiev, Sylvain Bouix, Martha E Shenton, Marek Kubicki, Thomas J Whitford, Simon McCarthy-Jones
Diffusion tensor imaging (DTI) studies in chronic schizophrenia have found widespread but often inconsistent patterns of white matter abnormalities. These studies have typically used the conventional measure of fractional anisotropy, which can be contaminated by extracellular free-water. A recent free-water imaging study reported reduced free-water corrected fractional anisotropy (FAT) in chronic schizophrenia across several brain regions, but limited changes in the extracellular volume. The present study set out to validate these findings in a substantially larger sample...
February 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28176263/multi-site-harmonization-of-diffusion-mri-data-in-a-registration-framework
#15
Hengameh Mirzaalian, Lipeng Ning, Peter Savadjiev, Ofer Pasternak, Sylvain Bouix, Oleg Michailovich, Sarina Karmacharya, Gerald Grant, Christine E Marx, Rajendra A Morey, Laura A Flashman, Mark S George, Thomas W McAllister, Norberto Andaluz, Lori Shutter, Raul Coimbra, Ross D Zafonte, Mike J Coleman, Marek Kubicki, Carl-Fredrik Westin, Murray B Stein, Martha E Shenton, Yogesh Rathi
Diffusion MRI (dMRI) data acquired on different scanners varies significantly in its content throughout the brain even if the acquisition parameters are nearly identical. Thus, proper harmonization of such data sets is necessary to increase the sample size and thereby the statistical power of neuroimaging studies. In this paper, we present a novel approach to harmonize dMRI data (the raw signal, instead of dMRI derived measures such as fractional anisotropy) using rotation invariant spherical harmonic (RISH) features embedded within a multi-modal image registration framework...
February 7, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28162167/-change-of-white-matter-neuronal-integrity-associated-with-spatial-navigation-impairment-in-mild-cognitive-impairment
#16
W P Li, F F Wang, J M Lu, S C Wu, W B Wu, R Y Liu, X Zhang, M Li, H Zhao, B Zhu, Y Xu, B Zhang
Objective: To analyze the correlation between white matter integrity and spatial navigation impairment in patients with mild cognitive impairment (MCI). Methods: A total of 27 MCI subjects and 24 healthy controls were enrolled from the Affiliated Drum Tower Hospital of Nanjing University Medical School from May 2015 to February 2016, who underwent 3.0 T MRI scan and 2D-computer version spatial navigation test.DTI preprocessing and tract-based spatial statistics (TBSS) were performed by PANDA.Two sample t-test and partial correlation coefficients were performed to investigate the correlation of white matter impairments and spatial navigation decline...
January 17, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28117841/white-matter-changes-in-microstructure-associated-with-a-maladaptive-response-to-stress-in-rats
#17
R Magalhães, J Bourgin, F Boumezbeur, P Marques, M Bottlaender, C Poupon, B Djemaï, E Duchesnay, S Mériaux, N Sousa, T M Jay, A Cachia
In today's society, every individual is subjected to stressful stimuli with different intensities and duration. This exposure can be a key trigger in several mental illnesses greatly affecting one's quality of life. Yet not all subjects respond equally to the same stimulus and some are able to better adapt to them delaying the onset of its negative consequences. The neural specificities of this adaptation can be essential to understand the true dynamics of stress as well as to design new approaches to reduce its consequences...
January 24, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28109978/structural-brain-alteration-in-survivors-of-acute-lymphoblastic-leukemia-with-chemotherapy-treatment-a-voxel-based-morphometry-and-diffusion-tensor-imaging-study
#18
Liwei Zou, Lianzi Su, Jiajia Xu, Li Xiang, Longsheng Wang, Zhimin Zhai, Suisheng Zheng
OBJECTIVE: To assess structural brain changes in survivors of acute lymphoblastic leukemia (ALL) with chemotherapy treatment by combining voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS). METHODS: 28 ALL patients (mean age: 40.71±8.58 years, years since diagnosis: 7-38) and 20 age-matched control subjects (mean age: 42.95±6.39 years) selected in this study with 3D T1 and diffusion tensor imaging acquired on a 3.0T Siemens MRI scanner. The ALL group had a history of chemotherapy treatment and off-therapy at least for 3 years was enrolled...
January 18, 2017: Brain Research
https://www.readbyqxmd.com/read/28107493/white-matter-abnormalities-in-two-different-subtypes-of-amnestic-mild-cognitive-impairment
#19
Jianghong Liu, Peipeng Liang, Linlin Yin, Ni Shu, Tengda Zhao, Yi Xing, Fangyu Li, Zhilian Zhao, Kuncheng Li, Ying Han
White matter (WM) degeneration has been found during the course of cognitive decline in both Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI), however, it is unclear whether there are different WM microstructural abnormalities between two subtypes of aMCI, including single domain aMCI (aMCI-s) and multiple domain aMCI (aMCI-m). Thirty-two patients of aMCI single-domain (aMCI-s), twenty-three patients of aMCI multiple-domain (aMCI-m) and twenty-three healthy normal controls (NC) participated in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28092023/white-matter-alterations-in-college-football-players-a-longitudinal-diffusion-tensor-imaging-study
#20
Michael Christian Mayinger, Kian Merchant-Borna, Jakob Hufschmidt, Marc Muehlmann, Isabelle Ruth Weir, Boris-Stephan Rauchmann, Martha Elizabeth Shenton, Inga Katharina Koerte, Jeffrey John Bazarian
The aim of this study was to evaluate longitudinal changes in the diffusion characteristics of brain white matter (WM) in collegiate athletes at three time points: prior to the start of the football season (T1), after one season of football (T2), followed by six months of no-contact rest (T3). Fifteen male collegiate football players and 5 male non-athlete student controls underwent diffusion MR imaging and computerized cognitive testing at all three timepoints. Whole-brain tract-based spatial statistics (TBSS) were used to compare fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), and trace between all timepoints...
January 14, 2017: Brain Imaging and Behavior
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