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https://www.readbyqxmd.com/read/28815853/changes-to-white-matter-microstructure-in-transient-ischemic-attack-a-longitudinal-diffusion-tensor-imaging-study
#1
Jennifer K Ferris, Jodi D Edwards, Jennifer A Ma, Lara A Boyd
Transient ischemic attack (TIA) is associated with localized ischemic changes, identifiable by diffusion-weighted imaging. Past research has not considered whether TIA is also associated with diffuse changes to white matter microstructure; further past work has not tracked changes longitudinally. Here we examine whole-brain changes in fractional anisotropy (FA) in individuals with TIA presenting with sensorimotor symptoms. Twenty individuals with a recent (within 30 days) TIA and 12 healthy older adults were recruited...
August 16, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28802959/a-combined-tract-based-spatial-statistics-and-voxel-based-morphometry-study-of-the-first-mri-scan-after-diagnosis-of-amyotrophic-lateral-sclerosis-with-subgroup-analysis
#2
A R Alruwaili, K Pannek, A Coulthard, R Henderson, N D Kurniawan, P McCombe
BACKGROUND AND PURPOSE: This study aims to compare the cortical and subcortical deep gray matter (GM) and white matter (WM) of ALS subjects and controls and to compare ALS subjects with (ALScog) and without (ALSnon-cog) cognitive impairment. MATERIALS AND METHODS: The study was performed in 30 ALS subjects, and 19 healthy controls. Structural T1- and diffusion-weighted MRI data were analyzed using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS)...
August 9, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28791662/combination-antiretroviral-therapy-improves-cognitive-performance-and-functional-connectivity-in-treatment-na%C3%A3-ve-hiv-infected-individuals
#3
Yuchuan Zhuang, Xing Qiu, Lu Wang, Qing Ma, Mark Mapstone, Amneris Luque, Miriam Weber, Madalina Tivarus, Eric Miller, Roberto C Arduino, Jianhui Zhong, Giovanni Schifitto
Our study aimed to investigate the short-term effect of combination antiretroviral therapy (cART) on cognitive performance and functional and structural connectivity and their relationship to plasma levels of antiretroviral (ARV) drugs. Seventeen ARV treatment-naïve HIV-infected individuals (baseline mean CD4 cell count, 479 ± 48 cells/mm(3)) were age matched with 17 HIV-uninfected individuals. All subjects underwent a detailed neurocognitive and functional assessment and magnetic resonance imaging. HIV-infected subjects were scanned before starting cART and 12 weeks after initiation of treatment...
August 8, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28756994/dual-energy-x-ray-absorptiometry-predictors-of-vertebral-deformities-in-beta-thalassemia-major
#4
Giangiacomo Osella, Adriano Massimiliano Priola, Sandro Massimo Priola, Antonio Piga, Filomena Longo, Massimo Ventura, Giuseppe Bentivegna, Alberto Angeli, Andrea Veltri, Massimo Terzolo
Vertebral fractures in beta-thalassemia major are increasingly found because of the longer life expectancy of patients, with a major negative impact on their quality of life. We performed a retrospective cross-sectional study to investigate the prevalence of vertebral deformities in thalassemic patients and to identify their best dual-energy X-ray absorptiometry (DXA) predictor among trabecular bone score (TBS), bone mineral density (BMD), and Z-score. Eighty-two outpatients with beta-thalassemia major on regular conventional treatment were studied at a single academic center...
July 27, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28729077/white-matter-microstructure-degenerates-in-patients-with-postherpetic-neuralgia
#5
Fuxiang Chen, Fuyong Chen, Zhanfang Shang, Yuan Shui, Guorong Wu, Chen Liu, Zhangya Lin, Yuanxiang Lin, Lianghong Yu, Dezhi Kang, Wei Tao, Yongjie Li
OBJECTIVE: The central mechanisms underlying postherpetic neuralgia (PHN) pain remains unknown. The primary purpose of this study was to identify microstructural white matter changes closely related to the PHN pain by means of diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS) analysis. METHODS: DTI data of the brains were obtained from 8 PHN patients and 8 healthy controls (HC) that were matched in age, gender, and educational level. DTI metrics, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD), were separately compared between the two groups using TBSS analysis to detect subtle microstructural changes...
July 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28721394/interhemispheric-disconnectivity-in-the-sensorimotor-network-in-bipolar-disorder-revealed-by-functional-connectivity-and-diffusion-tensor-imaging-analysis
#6
Takuya Ishida, Tomohiro Donishi, Jun Iwatani, Shinichi Yamada, Shun Takahashi, Satoshi Ukai, Kazuhiro Shinosaki, Masaki Terada, Yoshiki Kaneoke
BACKGROUND: Little is known regarding interhemispheric functional connectivity (FC) abnormalities via the corpus callosum in subjects with bipolar disorder (BD), which might be a key pathophysiological basis of emotional processing alterations in BD. METHODS: We performed tract-based spatial statistics (TBSS) using diffusion tensor imaging (DTI) in 24 healthy control (HC) and 22 BD subjects. Next, we analyzed the neural networks with independent component analysis (ICA) in 32HC and 25 BD subjects using resting-state functional magnetic resonance imaging...
June 2017: Heliyon
https://www.readbyqxmd.com/read/28710748/longitudinal-changes-in-white-matter-fractional-anisotropy-in-adult-onset-niemann-pick-disease-type-c-patients-treated-with-miglustat
#7
Elizabeth A Bowman, Dennis Velakoulis, Patricia Desmond, Mark Walterfang
Niemann-Pick disease type C (NPC) is a rare neurometabolic disorder resulting in impaired intracellular lipid trafficking. The only disease-modifying treatment currently available is miglustat, an iminosugar that inhibits the accumulation of lipid metabolites in neurons and other cells. This longitudinal diffusion tensor imaging (DTI) study examined how the rate of white matter change differed between treated and non-treated adult-onset NPC patient groups. Nine adult-onset NPC patients (seven undergoing treatment with miglustat, two not treated) underwent DTI neuroimaging...
July 15, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28709907/the-details-of-structural-disconnectivity-in-psychotic-disorder-a-family-based-study-of-non-fa-diffusion-weighted-imaging-measures
#8
Stijn Michielse, Ed Gronenschild, Patrick Domen, Jim van Os, Machteld Marcelis
BACKGROUND: Diffusion Tensor Imaging (DTI) studies in psychotic disorder have shown reduced FA, often interpreted as disturbed white matter integrity. The observed 'dysintegrity' may be of multifactorial origin, as changes in FA are thought to reflect a combination of changes in myelination, fiber organization and number of axons. Examining the structural substrate of the diffusion tensor in individuals with (risk for) psychotic disorder may provide better understanding of the underlying structural changes...
July 11, 2017: Brain Research
https://www.readbyqxmd.com/read/28702836/sequential-language-learning-and-language-immersion-in-bilingualism-diffusion-mri-connectometry-reveals-microstructural-evidence
#9
Farzaneh Rahmani, Soheila Sobhani, Mohammad Hadi Aarabi
Study of bilingual brain has provided evidence for probable advantageous outcomes of early second language learning and brain structural correlates to these outcomes. DMRI connectometry is a novel approach that tracts fibers based on correlation of the adjacent voxels with a variable of interest or group differences. Using the data deposited by Pliatsikas et al., we investigated through diffusion MRI connectometry and correlation analysis, the structural differences in white matter tracts of 20 healthy sequential bilingual adults who used English as a second language on a daily basis, compared to 25 age matched in fiber differentiation analyses...
July 12, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28688263/white-matter-correlates-of-impaired-attention-control-in-major-depressive-disorder-and-healthy-volunteers
#10
Mina M Rizk, Harry Rubin-Falcone, John Keilp, Jeffrey M Miller, M Elizabeth Sublette, Ainsley Burke, Maria A Oquendo, Ahmed M Kamal, Mohamed A Abdelhameed, J John Mann
BACKGROUND: Major depressive disorder (MDD) is associated with impaired attention control and alterations in frontal-subcortical connectivity. We hypothesized that attention control as assessed by Stroop task interference depends on white matter integrity in fronto-cingulate regions and assessed this relationship using diffusion tensor imaging (DTI) in MDD and healthy volunteers (HV). METHODS: DTI images and Stroop task were acquired in 29 unmedicated MDD patients and 16 HVs, aged 18-65 years...
November 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28676035/white-matter-damage-in-maintenance-hemodialysis-patients-a-diffusion-tensor-imaging-study
#11
David A Drew, Bang-Bon Koo, Rafeeque Bhadelia, Daniel E Weiner, Sarah Duncan, Maria Mendoza-De la Garza, Aditi Gupta, Hocine Tighiouart, Tammy Scott, Mark J Sarnak
BACKGROUND: Patients treated with dialysis have high rates of brain infarcts, brain atrophy, and white matter disease. There are limited data regarding the presence of more subtle damage to brain white matter. METHODS: In the Cognition and Dialysis Study, we compared brain structure using diffusion tensor imaging in hemodialysis (HD) patients to individuals without known kidney disease, using tract based spatial statistics (TBSS) to compare Fractional Anisotropy (FA) and Mean Diffusivity (MD)...
July 5, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28671333/diffusion-tensor-imaging-studies-of-attention-deficit-hyperactivity-disorder-meta-analyses-and-reflections-on-head-motion
#12
Yuta Aoki, Samuele Cortese, Francisco Xavier Castellanos
BACKGROUND: Diffusion tensor imaging studies have shown atypical fractional anisotropy (FA) in individuals with attention-deficit/hyperactivity disorder (ADHD), albeit with conflicting results. We performed meta-analyses of whole-brain voxel-based analyses (WBVBA) and tract-based spatial statistics (TBSS) studies in ADHD, along with a qualitative review of TBSS studies addressing the issue of head motion, which may bias results. METHODS: We conducted a systematic literature search (last search on April 1st, 2016) to identify studies comparing FA values between individuals with ADHD and typically developing (TD) participants...
July 3, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28670271/white-matter-tract-integrity-in-alzheimer-s-disease-vs-late-onset-bipolar-disorder-and-its-correlation-with-systemic-inflammation-and-oxidative-stress-biomarkers
#13
Ariadna Besga, Darya Chyzhyk, Itxaso Gonzalez-Ortega, Jon Echeveste, Marina Graña-Lecuona, Manuel Graña, Ana Gonzalez-Pinto
Background: Late Onset Bipolar Disorder (LOBD) is the development of Bipolar Disorder (BD) at an age above 50 years old. It is often difficult to differentiate from other aging dementias, such as Alzheimer's Disease (AD), because they share cognitive and behavioral impairment symptoms. Objectives: We look for WM tract voxel clusters showing significant differences when comparing of AD vs. LOBD, and its correlations with systemic blood plasma biomarkers (inflammatory, neurotrophic factors, and oxidative stress)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28658309/microstructural-integrity-of-white-matter-tracts-amongst-older-fallers-a-dti-study
#14
Yoke Queen Wong, Li Kuo Tan, Pohchoo Seow, Maw Pin Tan, Khairul Azmi Abd Kadir, Anushya Vijayananthan, Norlisah Ramli
OBJECTIVES: This study assesses the whole brain microstructural integrity of white matter tracts (WMT) among older individuals with a history of falls compared to non-fallers. METHODS: 85 participants (43 fallers, 42 non-fallers) were evaluated with conventional MRI and diffusion tensor imaging (DTI) sequences of the brain. DTI metrics were obtained from selected WMT using tract-based spatial statistics (TBSS) method. This was followed by binary logistic regression to investigate the clinical variables that could act as confounding elements on the outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28658249/similar-white-matter-changes-in-schizophrenia-and-bipolar-disorder-a-tract-based-spatial-statistics-study
#15
Letizia Squarcina, Marcella Bellani, Maria Gloria Rossetti, Cinzia Perlini, Giuseppe Delvecchio, Nicola Dusi, Marco Barillari, Mirella Ruggeri, Carlo A Altamura, Alessandra Bertoldo, Paolo Brambilla
Several strands of evidence reported a significant overlapping, in terms of clinical symptoms, epidemiology and treatment response, between the two major psychotic disorders-Schizophrenia (SCZ) and Bipolar Disorder (BD). Nevertheless, the shared neurobiological correlates of these two disorders are far from conclusive. This study aims toward a better understanding of possible common microstructural brain alterations in SCZ and BD. Magnetic Resonance Diffusion data of 33 patients with BD, 19 with SCZ and 35 healthy controls were acquired...
2017: PloS One
https://www.readbyqxmd.com/read/28648753/association-of-increased-genotypes-risk-for-bipolar-disorder-with-brain-white-matter-integrity-investigated-with-tract-based-spatial-statistics-special-section-on-translational-and-neuroscience-studies-in-affective-disorders-section-editor-maria-nobile-md-phd
#16
REVIEW
L Squarcina, J Houenou, A C Altamura, J Soares, P Brambilla
BACKGROUND: Diffusion tensor imaging (DTI) studies, which allow the in-vivo investigation of brain tissue integrity, have shown that bipolar disorder (BD) patients present signs of white matter dysconnectivity. In parallel, genome-wide association studies (GWAS) identified several risk genetic variants for BD. I METHODS: In this mini-review, we summarized DTI studies coupling tract-based spatial statistics (TBSS), a reliable technique exploring white matter axon bundles, and genetics in BD...
October 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28629742/statistical-differences-in-the-white-matter-tracts-in-subjects-with-depression-by-using-different-skeletonized-voxel-wise-analysis-approaches-and-dti-fitting-procedures
#17
Maurizio Bergamino, Madison Farmer, Hung-Wen Yeh, Elisabeth Paul, J Paul Hamilton
Major depressive disorder (MDD) is one of the most significant contributors to the global burden of illness. Diffusion tensor imaging (DTI) is a procedure that has been used in several studies to characterize abnormalities in white matter (WM) microstructural integrity in MDD. These studies, however, have provided divergent findings, potentially due to the large variety of methodological alternatives available in conducting DTI research. In order to determine the importance of different approaches to coregistration of DTI-derived metrics to a standard space, we compared results from two different skeletonized voxel-wise analysis approaches: the standard TBBS pipeline and the Advanced Normalization Tools (ANTs) approach incorporating a symmetric image normalization (SyN) algorithm and a group-wise template (ANTs TBSS)...
June 16, 2017: Brain Research
https://www.readbyqxmd.com/read/28627942/diffusion-imaging-of-mild-traumatic-brain-injury-in-the-impact-accelerated-rodent-model-a-pilot-study
#18
Zora Kikinis, Marc Muehlmann, Ofer Pasternak, Sharon Peled, Praveen Kulkarni, Craig Ferris, Sylvain Bouix, Yogesh Rathi, Inga K Koerte, Steve Pieper, Alexander Yarmarkovich, Caryn L Porter, Bruce S Kristal, Martha E Shenton
PRIMARY OBJECTIVE: There is a need to understand pathologic processes of the brain following mild traumatic brain injury (mTBI). Previous studies report axonal injury and oedema in the first week after injury in a rodent model. This study aims to investigate the processes occurring 1 week after injury at the time of regeneration and degeneration using diffusion tensor imaging (DTI) in the impact acceleration rat mTBI model. RESEARCH DESIGN: Eighteen rats were subjected to impact acceleration injury, and three rats served as sham controls...
June 19, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28609689/a-distinctive-abnormality-of-diffusion-tensor-imaging-parameters-in-the-fornix-of-patients-with-bipolar-ii-disorder
#19
Akeo Kurumaji, Michio Itasaka, Akihito Uezato, Kazuo Takiguchi, Daisuke Jitoku, Mizue Hobo, Toru Nishikawa
Diffusion tensor imaging (DTI) studies have revealed a changed integrity in the white matter of bipolar disorder. However, only a few investigations have examined bipolar II disorder (BP-II). A cross-sectional study was conducted to compare thirty-eight patients with BP-II (mean age = 38.26 years, F/M = 19/19) with thirty-eight age- and gender-matched healthy controls (mean age = 34.45 years, F/M = 18/20). Tract Based Spatial Statistics (TBSS) analysis of the fractional anisotropy (FA) was done with age, gender and education years as covariates, then a complementary atlas-based region-of-interest (ROI) analysis including the axial diffusivity (AD) and radial diffusivity (RD) was conducted to obtain further information...
June 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28579941/chronic-ketamine-exposure-causes-white-matter-microstructural-abnormalities-in-adolescent-cynomolgus-monkeys
#20
Qi Li, Lin Shi, Gang Lu, Hong-Luan Yu, Fu-Ki Yeung, Nai-Kei Wong, Lin Sun, Kai Liu, David Yew, Fang Pan, De-Feng Wang, Pak C Sham
Acute and repeated exposures to ketamine mimic aspects of positive, negative, and cognitive symptoms of schizophrenia in humans. Recent studies by our group and others have shown that chronicity of ketamine use may be a key element for establishing a more valid model of cognitive symptoms of schizophrenia. However, current understanding on the long-term consequences of ketamine exposure on brain circuits has remained incomplete, particularly with regard to microstructural changes of white matter tracts that underpin the neuropathology of schizophrenia...
2017: Frontiers in Neuroscience
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