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https://www.readbyqxmd.com/read/29453442/white-matter-integrity-in-medication-free-women-with-peripartum-depression-a-tract-based-spatial-statistics-study
#1
Michelle Silver, Constance M Moore, Vanessa Villamarin, Nina Jaitly, Janet E Hall, Anthony J Rothschild, Kristina M Deligiannidis
Diffusion tensor imaging (DTI) studies in depression show decreased structural connectivity in the left anterior limb of the internal capsule and the genu of the corpus callosum but no such studies exist in peripartum depression (PPD), which affects 1 in 8 women. We analyzed fractional anisotropy (FA) as a measure of white matter integrity of these two tracts using tract-based spatial statistics (TBSS). We then conducted an exploratory whole-brain analysis to identify additional regions implicated in PPD. Seventy-five pregnant, medication-free women were evaluated with the Edinburgh Postnatal Depression Scale (EPDS) and Structured Clinical Interview (SCID) for DSM-IV-TR in pregnancy and in the postpartum...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29383515/diffusion-tensor-imaging-in-metachromatic-leukodystrophy
#2
Diane F van Rappard, Marsh Königs, Marjan E Steenweg, Jaap Jan Boelens, Jaap Oosterlaan, Marjo S van der Knaap, Nicole I Wolf, Petra J W Pouwels
OBJECTIVE: We aimed to gain more insight into the pathomechanisms of metachromatic leukodystrophy (MLD), by comparing magnitude and direction of diffusion between patients and controls at diagnosis and during follow-up. METHODS: Four late-infantile, 16 juvenile and 8 adult onset MLD patients [of which 13 considered eligible for hematopoietic cell transplantation (HCT)] and 47 controls were examined using diffusion tensor imaging. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) were quantified and compared between groups using tract-based spatial statistics (TBSS)...
January 30, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29378320/white-matter-microstructural-variability-mediates-the-relation-between-obesity-and-cognition-in-healthy-adults
#3
Rui Zhang, Frauke Beyer, Leonie Lampe, Tobias Luck, Steffi G Riedel-Heller, Markus Loeffler, Matthias L Schroeter, Michael Stumvoll, Arno Villringer, A Veronica Witte
Obesity has been linked with structural and functional brain changes. However, the impact of obesity on brain and cognition in aging remains debatable, especially for white matter. We therefore aimed to determine the effects of obesity on white matter microstructure and potential implications for cognition in a well-characterized large cohort of healthy adults. In total, 1255 participants (50% females, 19-80 years, BMI 16.8-50.2 kg/m2) with diffusion-weighted magnetic resonance imaging at 3T were analysed...
January 25, 2018: NeuroImage
https://www.readbyqxmd.com/read/29368035/alteration-of-putaminal-fractional-anisotropy-in-parkinson-s-disease-a-longitudinal-diffusion-kurtosis-imaging-study
#4
Yulia Surova, Markus Nilsson, Björn Lampinen, Jimmy Lätt, Sara Hall, Håkan Widner, Danielle van Westen, Oskar Hansson
PURPOSE: In Parkinson's disease (PD), pathological microstructural changes occur that may be detected using diffusion magnetic resonance imaging (dMRI). However, there are few longitudinal studies that explore the effect of disease progression on diffusion indices. METHODS: We prospectively included 76 patients with PD and 38 healthy controls (HC), all of whom underwent diffusion kurtosis imaging (DKI) as part of the prospective Swedish BioFINDER study at baseline and 2 years later...
January 24, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29362992/white-matter-integrity-correlates-with-residual-consciousness-in-patients-with-severe-brain-injury
#5
Lubin Wang, Yi Yang, Shanshan Chen, Mingmei Ge, Jianghong He, Zheng Yang, Pan Lin, Xinhuai Wu
Previous studies have suggested that white matter disruption plays an important role in disorders of consciousness (DOC) after severe brain injury. Nevertheless, the integrity of white matter architecture supporting consciousness and its relations with clinical severity in patients with DOC remain to be established. In this study, diffusion tensor imaging (DTI) data was collected from 14 DOC patients and 15 healthy control subjects. We combined tract-based spatial statistics (TBSS) with region of interest (ROI) analysis to examine differences of DTI metrics on white matter skeletons between DOC patients and healthy controls, and the association between white matter integrity and patients' residual consciousness assessed by Coma Recovery Scale-Revised (CRS-R)...
January 23, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29362155/pseudoexfoliation-syndrome-without-glaucoma-white-matter-abnormalities-detected-by-conventional-mri-and-diffusion-tensor-imaging
#6
Anastasia K Zikou, George Kitsos, Loukas G Astrakas, Vasileios G Xydis, Konstantinos Spiliopoulos, Eleni Bagli, Maria I Argyropoulou
PURPOSE: To assess macro- and microstructural brain changes in patients with pseudoexfoliation syndrome (PXS). MATERIALS AND METHODS: Comprehensive ophthalmic examination and brain MRI were conducted on 20 patients with PXS without glaucoma (aged 62.75 ± 0.4 years) and 20 controls (aged 62 ± 0.6 years). White matter (WM) integrity was evaluated on FLAIR and single-shot multisection SE-EPI diffusion tensor imaging (DTI) sequences. The presence and the number of white matter hyperintensities (WMHIs) on FLAIR images was compared between all patients and control subjects...
February 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29356252/white-matter-integrity-disruptions-correlate-with-cognitive-impairments-in-asthma
#7
Rongrong Bian, Yuqun Zhang, Yuan Yang, Yingying Yin, Xiaoxin Zhao, Huanxin Chen, Yonggui Yuan
BACKGROUND: Cognitive impairments are common in asthma, which is a serious global health problem characterized by chronic airway inflammation. However, the underlying neuromechanism is still unclear. PURPOSE/HYPOTHESIS: To investigate the neuromechanism underlying cognitive impairments of asthma. We hypothesized that asthma patients exhibit altered white matter (WM) microstructures, which may contribute to their cognitive impairments. STUDY TYPE: Case-control study...
January 21, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29350598/diffusion-tensor-imaging-and-ventricle-volume-quantification-in-patients-with-chronic-shunt-treated-hydrocephalus-a-matched-case-control-study
#8
Kristy Tan, Avital Meiri, Wenzhu B Mowrey, Rick Abbott, James T Goodrich, Adam L Sandler, Asif K Suri, Michael L Lipton, Mark E Wagshul
OBJECTIVE The object of this study was to use diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS) to characterize the long-term effects of hydrocephalus and shunting on white matter integrity and to investigate the relationship of ventricular size and alterations in white matter integrity with headache and quality-of-life outcome measures. METHODS Patients with shunt-treated hydrocephalus and age- and sex-matched healthy controls were recruited into the study and underwent anatomical and DTI imaging on a 3-T MRI scanner...
January 19, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29347868/differential-white-matter-regional-alterations-in-motor-subtypes-of-early-drug-naive-parkinson-s-disease-patients
#9
Ming-Ching Wen, Hannah S E Heng, Zhonghao Lu, Zheyu Xu, Ling Ling Chan, Eng King Tan, Louis C S Tan
BACKGROUND: Parkinson's disease (PD) can be classified into tremor dominant (TD) and postural instability and gait difficulty (PIGD) subtypes with TD considered as the benign subtype. The neural alterations of the 2 subtypes in the early stages before administration of medications remain elusive. OBJECTIVE: This study assessed the subtype-related white matter (WM) microstructural features in newly diagnosed and drug-naive PD patients from the Parkinson's Progression Markers Initiative (PPMI)...
January 1, 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29338891/gray-and-white-matter-changes-and-their-relation-to-illness-trajectory-in-first-episode-psychosis
#10
Alejandro Keymer-Gausset, Anna Alonso-Solís, Iluminada Corripio, Rosa B Sauras-Quetcuti, Edith Pomarol-Clotet, Erick J Canales-Rodriguez, Eva Grasa-Bello, Enric Álvarez, Maria J Portella
Previous works have studied structural brain characteristics in first-episode psychosis (FEP), but few have focused on the relation between brain differences and illness trajectories. The aim of this study is to analyze gray and white matter changes in FEP patients and their relation with one-year clinical outcomes. A sample of 41 FEP patients and 41 healthy controls (HC), matched by age and educational level was scanned with a 3T MRI during the first month of illness onset. One year later, patients were assigned to two illness trajectories (schizophrenia and non-schizophrenia)...
January 12, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29326869/prenatal-methadone-exposure-is-associated-with-altered-neonatal-brain-development
#11
Victoria J Monnelly, Devasuda Anblagan, Alan Quigley, Manuel Blesa Cabez, E Sarah Cooper, Helen Mactier, Scott I Semple, Mark E Bastin, James P Boardman
Methadone is used for medication-assisted treatment of heroin addiction during pregnancy. The neurodevelopmental outcome of children with prenatal methadone exposure can be sub-optimal. We tested the hypothesis that brain development is altered among newborn infants whose mothers were prescribed methadone. 20 methadone-exposed neonates born after 37 weeks' postmenstrual age (PMA) and 20 non-exposed controls underwent diffusion MRI at mean PMA of 39+ 2 and 41+ 1 weeks, respectively. An age-optimized Tract-based Spatial Statistics (TBSS) pipeline was used to perform voxel-wise statistical comparison of fractional anisotropy (FA) data between exposed and non-exposed neonates...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29322222/urinary-pentosidine-levels-negatively-associates-with-trabecular-bone-scores-in-patients-with-type-2-diabetes-mellitus
#12
Y J Choi, S Y Ock, Y Jin, J S Lee, S H Kim, Y -S Chung
Pentosidine levels were higher in diabetic patients with vertebral fractures. Trabecular bone scores were negatively associated with pentosidine levels in diabetic patients only. Our results provide further evidence that AGEs are associated with the pathogenesis of bone fragility in patients with T2DM. INTRODUCTION: Type 2 diabetes mellitus (T2DM) is associated with fracture risk. Pentosidine, an advanced glycation end product (AGE), is associated with prevalent vertebral fractures (VFs) in patients with T2DM...
January 10, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29316038/effect-of-dimethyl-fumarate-on-gray-and-white-matter-pathology-in-subjects-with-relapsing-multiple-sclerosis-a-longitudinal-study
#13
Robert Zivadinov, Jesper Hagemeier, Niels Bergsland, Eleonora Tavazzi, Bianca Weinstock-Guttman
BACKGROUND: Dimethyl fumarate (DMF) is an oral treatment for relapsing remitting multiple sclerosis (RRMS) with anti-inflammatory and possible neuroprotective properties. Its effect on white matter (WM) and gray matter (GM) pathology is still not fully understood. OBJECTIVE: To characterize the effect of DMF on normal appearing WM (NAWM) and thalamic pathology longitudinally. METHODS: In this observational, longitudinal, 24-month MRI study, 75 RRMS treated with DMF and 40 age- and sex- matched healthy individuals (HIs) were enrolled...
January 5, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29315514/cytotoxic-edema-at-onset-in-west-syndrome-of-unknown-etiology-a-longitudinal-diffusion-tensor-imaging-study
#14
Chikako Ogawa, Hiroyuki Kidokoro, Tatsuya Fukasawa, Hiroyuki Yamamoto, Naoko Ishihara, Yuji Ito, Yoko Sakaguchi, Yu Okai, Atsuko Ohno, Tomohiko Nakata, Yoshiteru Azuma, Ayako Hattori, Tetsuo Kubota, Takeshi Tsuji, Akihiro Hirakawa, Hisashi Kawai, Jun Natsume
OBJECTIVE: To clarify longitudinal changes in white matter microstructures from the onset of disease in patients with West syndrome (WS) of unknown etiology. METHODS: Diffusion tensor imaging (DTI) was prospectively performed at onset and at 12 and 24 months old in 17 children with WS of unknown etiology. DTI was analyzed using tract-based spatial statistics (TBSS) and tract-specific analysis (TSA) of 13 fiber tracts, and fractional anisotropy (FA) and mean diffusivity (MD) were compared with those of 42 age-matched controls...
January 8, 2018: Epilepsia
https://www.readbyqxmd.com/read/29273881/altered-white-matter-microstructure-in-conduct-disorder-is-specifically-associated-with-elevated-callous-unemotional-traits
#15
Ignazio Puzzo, Kiran Seunarine, Kate Sully, Angela Darekar, Chris Clark, Edmund J S Sonuga-Barke, Graeme Fairchild
Adolescents with conduct disorder (CD) and elevated callous-unemotional (CU) traits have been reported to present with a more severe and persistent pattern of antisocial behaviour than those with low levels of CU traits. However, relatively few studies have investigated whether there are differences in brain structure between these subgroups.We acquired diffusion tensor imaging data and used tract-based spatial statistics (TBSS) to compare adolescents with CD and high levels of CU traits (CD/CU+; n = 18, CD and low levels of CU traits (CD/CU-; n = 17) and healthy controls (HC; n = 32) on measures of fractional anisotropy (FA), axial (AD), radial (RD) and mean (MD) diffusivity...
December 22, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29239261/white-matter-tract-integrity-an-indicator-of-axonal-pathology-after-mild-traumatic-brain-injury
#16
Sohae Chung, Els Fieremans, Xiuyuan Wang, Nuri E Kucukboyaci, Charles J Morton, James S Babb, Prin Amorapanth, Farng-Yang Foo, Dmitry S Novikov, Steven R Flanagan, Joseph F Rath, Yvonne W Lui
We seek to elucidate the underlying pathophysiology of injury sustained after mild traumatic brain injury (MTBI) using multi-shell diffusion MRI, deriving compartment-specific WM tract integrity (WMTI) metrics. WMTI allows a more biophysical interpretation of WM changes by describing microstructural characteristics in both intra- and extra-axonal environments. Thirty-two patients with MTBI within 30 days of injury and twenty-one age- and sex-matched controls were imaged on a 3T MR scanner. Multi-shell diffusion acquisition was performed with 5 b-values (250 - 2500 s/mm<sup>2</sup>) along 6 - 60 diffusion encoding directions...
December 14, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29226284/gray-matter-surface-based-spatial-statistics-gs-bss-in-diffusion-microstructure
#17
Prasanna Parvathaneni, Baxter P Rogers, Yuankai Huo, Kurt G Schilling, Allison E Hainline, Adam W Anderson, Neil D Woodward, Bennett A Landman
Tract-based spatial statistics (TBSS) has proven to be a popular technique for performing voxel-wise statistical analysis that aims to improve sensitivity and interpretability of analysis of multi-subject diffusion imaging studies in white matter. With the advent of advanced diffusion MRI models - e.g., the neurite orientation dispersion density imaging (NODDI), it is of interest to analyze microstructural changes within gray matter (GM). A recent study has proposed using NODDI in gray matter based spatial statistics (N-GBSS) to perform voxel-wise statistical analysis on GM microstructure...
September 2017: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/29216635/deficits-in-docosahexaenoic-acid-accrual-during-adolescence-reduce-rat-forebrain-white-matter-microstructural-integrity-an-in-vivo-diffusion-tensor-imaging-study
#18
Robert K McNamara, Jennifer D Schurdak, Ruth H Asch, Bart D Peters, Diana M Lindquist
Neuropsychiatric disorders that frequently initially emerge during adolescence are associated with deficits in the omega-3 (n-3) fatty acid docosahexaenoic acid (DHA), elevated proinflammatory signaling, and regional reductions in white matter integrity (WMI). This study determined the effects of altering brain DHA accrual during adolescence on WMI in the rat brain by diffusion tensor imaging (DTI), and investigated the potential mediating role of proinflammatory signaling. During periadolescent development, male rats were fed a diet deficient in n-3 fatty acids (DEF, n = 20), a fish oil-fortified diet containing preformed DHA (FO, n = 20), or a control diet (CON, n = 20)...
December 8, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/29204342/sex-differences-in-white-matter-alterations-following-repetitive-subconcussive-head-impacts-in-collegiate-ice-hockey-players
#19
Nico Sollmann, Paul S Echlin, Vivian Schultz, Petra V Viher, Amanda E Lyall, Yorghos Tripodis, David Kaufmann, Elisabeth Hartl, Philipp Kinzel, Lorie A Forwell, Andrew M Johnson, Elaine N Skopelja, Christian Lepage, Sylvain Bouix, Ofer Pasternak, Alexander P Lin, Martha E Shenton, Inga K Koerte
Objective: Repetitive subconcussive head impacts (RSHI) may lead to structural, functional, and metabolic alterations of the brain. While differences between males and females have already been suggested following a concussion, whether there are sex differences following exposure to RSHI remains unknown. The aim of this study was to identify and to characterize sex differences following exposure to RSHI. Methods: Twenty-five collegiate ice hockey players (14 males and 11 females, 20...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29199095/analysis-of-white-matter-characteristics-with-tract-based-spatial-statistics-according-to-diffusion-tensor-imaging-in-early-parkinson-s-disease
#20
Xiang-Rong Li, Yan-De Ren, Bo Cao, Xuan-Li Huang
OBJECTIVE: To analyze the microstructure of brain white matter according to diffusion tensor imaging (DTI) based on tract-based spatial statistics (TBSS) in early Parkinson's disease (PD). MATERIALS AND METHODS: A total of 31 age- and sex-matched early PD patients and 22 healthy volunteers were recruited in the present study. DTI was performed, and the data analyzed with fsl4.0 software. The fractional anisotropy (FA) was compared between both groups with an independent t test, and the differential area was analyzed...
November 30, 2017: Neuroscience Letters
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