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Ming-Ching Wen, Hannah S E Heng, Samuel Y E Ng, Louis C S Tan, Ling Ling Chan, Eng King Tan
Parkinson's disease (PD) is a debilitating neurodegenerative disorder. Findings on specific white matter (WM) alterations in PD have been inconsistent. We hypothesized that WM changes occur in early PD patients and unbiased whole-brain analysis may provide additional evidence of pathological WM changes in PD. In this study, we examined various indexes of WM microstructure in newly diagnosed PD patients at the whole-brain level. 64 PDs with Hoehn &Yahr stage 1 (HY1PDs), 87 PDs with Hoehn &Yahr stage 2 (HYPD2s), and 60 controls (HCs) were recruited...
October 20, 2016: Scientific Reports
Yi-Bin Xi, Fan Guo, Hua Li, Xiao Chang, Jin-Bo Sun, Yuan-Qiang Zhu, Wen-Ming Liu, Long-Biao Cui, Gang Chen, Hua-Ning Wang, Hong Yin
Heterogeneous findings across studies of structural abnormality in schizophrenia (SZ) have impeded the development a unified theory of white matter pathology. As a cardinal symptom of SZ, auditory verbal hallucination (AVH) has been suspected to be associated with improper communication among several brain regions, which might indicated white matter pathology. Participants comprised 25 first-episode (FE) patients with AVH, 25 patients without AVH and 25 healthy subjects. Diffusion tensor imaging (DTI) measures were calculated using the TBSS of FSL...
September 28, 2016: Psychiatry Research
Zora Kikinis, Kang Ik K Cho, Ioana L Coman, Petya D Radoeva, Sylvain Bouix, Yingying Tang, Ryan Eckbo, Nikos Makris, Jun Soo Kwon, Marek Kubicki, Kevin M Antshel, Wanda Fremont, Martha E Shenton, Wendy R Kates
BACKGROUND: 22q11.2 Deletion Syndrome (22q11DS) is considered to be a promising cohort to explore biomarkers of schizophrenia risk based on a 30 % probability of developing schizophrenia in adulthood. In this study, we investigated abnormalities in the microstructure of white matter in adolescents with 22q11DS and their specificity to prodromal symptoms of schizophrenia. METHODS: Diffusion Magnetic Resonance Imaging (dMRI) data were acquired from 50 subjects with 22q11DS (9 with and 41 without prodromal psychotic symptoms), and 47 matched healthy controls (mean age 18 +/-2 years)...
October 11, 2016: Brain Imaging and Behavior
Diane Goldenberg, Eva H Telzer, Matthew D Lieberman, Andrew J Fuligni, Adriana Galván
Adolescence is a period of learning, exploration, and continuous adaptation to fluctuating environments. Response variability during adolescence is an important, understudied, and developmentally-appropriate behavior. The purpose of this study was to identify the association between performance on a dynamic risky decision making task and white matter microstructure in a sample of 48 adolescents (14-16 yrs). Individuals with the greatest response variability on the task obtained the widest range of experience with potential outcomes to risky choice...
September 20, 2016: Social Cognitive and Affective Neuroscience
Farida Grinberg, Ivan I Maximov, Ezequiel Farrher, Irene Neuner, Laura Amort, Heike Thönneßen, Eileen Oberwelland, Kerstin Konrad, N Jon Shah
The most common modality of diffusion MRI used in the ageing and development studies is diffusion tensor imaging (DTI) providing two key measures, fractional anisotropy and mean diffusivity. Here, we investigated diffusional changes occurring between childhood (average age 10.3 years) and mitddle adult age (average age 54.3 years) with the help of diffusion kurtosis imaging (DKI), a recent novel extension of DTI that provides additional metrics quantifying non-Gaussianity of water diffusion in brain tissue...
September 14, 2016: NeuroImage
Jin Fang, Shumei Li, Meng Li, Queenie Chan, Xiaofen Ma, Huanhuan Su, Tianyue Wang, Wenfeng Zhan, Jianhao Yan, Ming Xu, Yaxi Zhang, Luxian Zeng, Junzhang Tian, Guihua Jiang
The neural mechanisms underlying the pathophysiology of irritable bowel syndrome(IBS) are far from being completely understood. The purpose of the present study was to investigate potential white matter (WM) microstructural changes and underlying causes for WM impairment in IBS using diffusion tensor imaging. The present prospective study involved 19 patients with IBS and 20 healthy controls. Whole-brain voxel-wise analyses of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were performed by tract-based spatial statistics (TBSS) to localize abnormal WM regions between the 2 groups...
September 14, 2016: Brain Imaging and Behavior
Ying Xiong, Xiaohong Joe Zhou, Robyn A Nisi, Kelly R Martin, M Muge Karaman, Kejia Cai, Terri E Weaver
PURPOSE: To investigate white matter (WM) structural alterations using diffusion tensor imaging (DTI) in obstructive sleep apnea (OSA) patients, with or without residual sleepiness, following adherent continuous positive airway pressure (CPAP) treatment. Possible quantitative relationships were explored between the DTI metrics and two clinical assessments of somnolence. MATERIALS AND METHODS: Twenty-nine male patients (30-55 years old) with a confirmed diagnosis of OSA were recruited...
September 14, 2016: Journal of Magnetic Resonance Imaging: JMRI
Chuanjun Zhuo, Xiaolei Ma, Hongru Qu, Lina Wang, Feng Jia, Chunli Wang
Fractional anisotropy (FA) and mean diffusivity (MD) are the most frequently used metrics to investigate white matter impairments in mental disorders. However, these two metrics are derived from intra-voxel analyses and only reflect the diffusion properties solely within the voxel unit. Local diffusion homogeneity (LDH) is a newly developed inter-voxel metric which quantifies the local coherence of water molecule diffusion in a model-free manner. In this study, 94 schizophrenia patients and 91 sex- and age-matched healthy controls underwent diffusion tensor imaging (DTI) examinations...
2016: PloS One
Patty Coker-Bolt, Andrew Barbour, Hunter Moss, Jordan Tillman, Emma Humphries, Emily Ward, Truman Brown, Dorothea Jenkins
PURPOSE: Diffusion tensor imaging (DTI) can detect injury to specific white matter (WM) tracts involved with sensorimotor processing and may provide sensitive measures for latent or nascent motor skills. We hypothesized that DTI measures of WM fractional anisotropy (FA) could predict early motor scores on a standardized assessment in a cohort of preterm infants at risk for WM injury. METHODS: In this prospective study, preterm infants (n= 26, 11 female, 15 male, mean gestational age 29...
September 2, 2016: Journal of Pediatric Rehabilitation Medicine
J Gan, J Yi, M Zhong, X Cao, X Jin, W Liu, X Zhu
OBJECTIVE: The pathogenesis of borderline personality disorder (BPD) is not well understood. We examined the microstructure of white matter in patients with BPD. METHOD: Treatment-naïve young adult with BPD (N = 30) and young-adult healthy controls (HCs; N = 31) were subjected diffusion tensor imaging (DTI). Microstructural parameters were analyzed via tract-based spatial statistics (TBSS) and post hoc tractography. RESULTS: TBSS analysis revealed that, relative to the HC group, the BPD group had significantly lower fractional anisotropy (FA) values in the genu and body of the corpus callosum (CC), right superior corona radiate, right anterior corona radiate, as well as higher radial diffusivity (RD) in the left anterior thalamic radiation...
September 9, 2016: Acta Psychiatrica Scandinavica
Anahit Grigorian, Larissa McKetton, Keith A Schneider
In albinism, the number of ipsilaterally projecting retinal ganglion cells (RGCs) is significantly reduced. The retina and optic chiasm have been proposed as candidate sites for misrouting. Since a correlation between the number of lateral geniculate nucleus (LGN) relay neurons and LGN size has been shown, and based on previously reported reductions in LGN volumes in human albinism, we suggest that fiber projections from LGN to the primary visual cortex (V1) are also reduced. Studying structural differences in the visual system of albinism can improve the understanding of the mechanism of misrouting and subsequent clinical applications...
2016: Journal of Visualized Experiments: JoVE
Matthew Leming, Rachel Steiner, Martin Styner
Tract-based spatial statistics (TBSS)(6) is a software pipeline widely employed in comparative analysis of the white matter integrity from diffusion tensor imaging (DTI) datasets. In this study, we seek to evaluate the relationship between different methods of atlas registration for use with TBSS and different measurements of DTI (fractional anisotropy, FA, axial diffusivity, AD, radial diffusivity, RD, and medial diffusivity, MD). To do so, we have developed a novel tool that builds on existing diffusion atlas building software, integrating it into an adapted version of TBSS called DAB-TBSS (DTI Atlas Builder-Tract-Based Spatial Statistics) by using the advanced registration offered in DTI Atlas Builder(7)...
February 27, 2016: Proceedings of SPIE
L Brambilla, D Rossi Sebastiano, D Aquino, V Torri Clerici, G Brenna, M Moscatelli, R Frangiamore, A M Giovannetti, C Antozzi, R Mantegazza, S Franceschetti, M G Bruzzone, A Erbetta, P Confalonieri
BACKGROUND: 4-aminopyridine (4-AP) is a potassium-channel blocker able to enhance walking speed in MS improving the action potentials of demyelinated axons on which internodal potassium channels are exposed. OBJECTIVE: to study early 4-AP effect with clinical, subjective, neurophysiological and neuroradiological tools. METHODS: Clinical (Timed 25-Foot Walk - T25FW, Timed Up-And-Go - TUG), subjective (MS Walking Scale-12 - MSWS-12), neurophysiological (Motor Evoked Potentials - MEPs) and imaging (Diffusion Tensor Imaging - DTI) evaluations were performed before (T0) and after (T1) 14days of 4-AP treatment...
September 15, 2016: Journal of the Neurological Sciences
Wei Wang, Shaowen Qian, Kai Liu, Bo Li, Min Li, Kuolin Xin, Gang Sun
The purpose of this study was to explore white matter microstructural alterations in the patients with generalized anxiety disorder (GAD) using diffusion tensor imaging (DTI) technique, and to assess neural associations with the symptom severity. Twenty-eight first-episode, treatment-naive GAD patients without co-morbidities and 28 matched healthy controls underwent DTI acquisition and clinical symptom assessments. Tract-based spatial statistics (TBSS) was used to analyze white matter microstructural abnormalities in patients with GAD, as well as their associations with clinical symptom scores in a voxel-wise manner...
November 1, 2016: Behavioural Brain Research
Alexander Drobyshevsky
PURPOSE: To examine the extent of gray and white matter (WM) injury following global antenatal hypoxia-ischemia (H-I) and resulting in muscle hypertonia in newborns in a rabbit cerebral palsy model. MATERIALS AND METHODS: Rabbit dams (n = 15) underwent uterine ischemia procedure resulting in a global fetal H-I at embryonic day 22 (embryonic 22 days gestation). Newborn's brains underwent high resolution diffusion tensor imaging on a 14 Tesla magnet ex vivo. Fractional anisotropy (FA) in brains of hypertonic (n = 9), nonhypertonic (n = 6), and sham control (n = 5) kits were compared voxel-wise using Tract-Based Spatial Statistics (TBSS) approach...
August 9, 2016: Journal of Magnetic Resonance Imaging: JMRI
Amity E Green, Rodney J Croft, Jerome J Maller, Paul B Fitzgerald
Episodic memory (EM) impairments in schizophrenia (SZ) are predictive of functional outcome and are a potential endophenotype of the disorder. The current study investigated the neuroanatomical correlates of EM encoding and retrieval in SZ with structural magnetic resonance and diffusion tensor imaging (DTI) measures in 22 patients with SZ and 22 age- and gender-matched healthy controls. Tract-based Spatial Statistics (TBSS) was used to investigate microstructural alterations in white matter (WM), while FreeSurfer surface-based analysis was used to determine abnormalities in grey matter (GM) and WM volumetrics and cortical thickness...
August 30, 2016: Psychiatry Research
Xianjun Li, Jie Gao, Miaomiao Wang, Mingxi Wan, Jian Yang
PURPOSE: The relatively poor image contrast and variation in the neonatal brain size are technical challenges associated with the typical tract-based spatial statistics (TBSS) for the target identification and normalization. This study aimed to develop a rapid and reliable pipeline for the neonatal TBSS. MATERIALS AND METHODS: A rapid TBSS strategy was proposed based on the group-wise target choice for fractional anisotropy (FA) derived from diffusion tensor imaging (DTI)...
November 2016: Magnetic Resonance Imaging
Sila Genc, Vicki Anderson, Nicholas Peter Ryan, Charles B Malpas, Cathy Catroppa, Miriam Helen Beauchamp, Tim J Silk
Previous studies in paediatric traumatic brain injury (TBI) have been variable in describing the effects of injury severity on white matter development. The present study used diffusion tensor imaging to investigate prospective sub-acute and longitudinal relationships between early clinical indicators of injury severity, diffusion metrics, and neuropsychological outcomes. Paediatric TBI patients underwent MR imaging (n = 78, M = 10.56, SD = 2.21 years of age) at the sub-acute stage following injury (M = 5.55, SD = 3...
July 28, 2016: Journal of Neurotrauma
Lizhou Chen, Xinyu Hu, Luo Ouyang, Ning He, Yi Liao, Qi Liu, Ming Zhou, Min Wu, Xiaoqi Huang, Qiyong Gong
Diffusion tensor imaging (DTI) studies that use tract-based spatial statistics (TBSS) have demonstrated the microstructural abnormalities of white matter (WM) in patients with attention-deficit/hyperactivity disorder (ADHD); however, robust conclusions have not yet been drawn. The present study integrated the findings of previous TBSS studies to determine the most consistent WM alterations in ADHD via a narrative review and meta-analysis. The literature search was conducted through October 2015 to identify TBSS studies that compared fractional anisotropy (FA) between ADHD patients and healthy controls...
September 2016: Neuroscience and Biobehavioral Reviews
Sigrid Baldanzi, Paolo Cecchi, Serena Fabbri, Ilaria Pesaresi, Costanza Simoncini, Corrado Angelini, Ubaldo Bonuccelli, Mirco Cosottini, Gabriele Siciliano
Myotonic dystrophy type 1 (DM1) has a wide phenotypic spectrum and potentially may affect central nervous system with mild to severe involvement. Our aim was to investigate grey matter (GM) and white matter (WM) structural alterations in a sample of adult-onset DM1 patients and to evaluate relationship with clinical and cognitive variables. Thirty DM1 patients underwent neuropsychological investigation and 3T-MRI protocol. GM and WM changes were evaluated calculating brain parenchymal fraction (BPF), voxel-based morphometry (VBM), white matter lesion load (LL% and Fazekas scale) and tract based spatial statistical (TBSS)...
2016: NeuroImage: Clinical
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