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Hair AND Biotin

Ching-Chang Lin, Da-Shiuan Sun, Ya-Lin Lin, Tsung-Tso Tsai, Chieh Cheng, Wen-Hsien Sun, Fu-Hsiang Ko
A flexible and miniaturized metal semiconductor metal (MSM) biomolecular photodetector was developed as the core photocurrent system through chemiluminescence for hydrogen peroxide sensing. The flexible photocurrent sensing system was manufactured on a 30-µm-thick crystalline silicon chip by chemical etching process, which produced a flexible silicon chip. A surface texturization design on the flexible device enhanced the light-trapping effect and minimized reflectivity losses from the incident light. The model protein streptavidin bound to horseradish peroxidase (HRP) was successfully immobilized onto the sensor surface through high-affinity conjugation with biotin...
April 15, 2017: Biosensors & Bioelectronics
Ralph M Trüeb
Biotin is a coenzyme for carboxylase enzymes that assist various metabolic reactions involved in fatty acid synthesis, branched-chain amino acid catabolism, and gluconeogenesis important for maintenance of healthy skin and hair. Due to its availability, affordability, and effective marketing for this purpose, biotin is a popular nutritional supplement for treatment of hair loss. However, there are little data on the frequency of biotin deficiency in patients complaining of hair loss and on the value of oral biotin for treatment of hair loss that is not due to an inborn error of biotin metabolism or deficiency...
April 2016: International Journal of Trichology
Mohamed A Adly, Hanan A Assaf, Mahmoud Rezk Abdelwahed Hussein
Glial cell line-derived neurotrophic factor (GDNF) and its cognate receptor (GFRα-1) are expressed in normal human skin. They are involved in murine hair follicle morphogenesis and cycling control. We hypothesize that 'GDNF and GFRα-1 protein expression in human skin undergoes age-associated alterations. To test our hypothesis, the expression of these proteins was examined in human skin specimens obtained from 30 healthy individuals representing three age groups: children (5-18 years), adults (19-60 years) and the elderly (61-81 years)...
June 2016: International Journal of Experimental Pathology
Jiwon Chang, June Choi, Yoon Chan Rah, Myung Hoon Yoo, Kyoung Ho Oh, Gi Jung Im, Seung Hoon Lee, Soon Young Kwon, Hae-Chul Park, Sung Won Chae, Hak Hyun Jung
Sodium selenite is a trace element essential for many physiological functions in the body. It is involved in various biological processes; it acts as a cofactor for antioxidant enzymes that protect against free radicals and is reported to limit metal-mediated oxidative DNA damage. In the present study, we investigated the effect of sodium selenite on neomycin ototoxicity in wild-type and transgenic zebrafish (Brn3C: EGFP). Five or six days post-fertilization, zebrafish larvae were co-exposed to 125 μM neomycin and various concentrations (10 μM, 100 μM, 250 μM, and 500 μM) of sodium selenite for 1 h...
2016: PloS One
Marcin Kazmierczak, Suzan L Harris, Piotr Kazmierczak, Prahar Shah, Valentin Starovoytov, Kevin K Ohlemiller, Martin Schwander
UNLABELLED: Disordered protein ubiquitination has been linked to neurodegenerative disease, yet its role in inner ear homeostasis and hearing loss is essentially unknown. Here we show that progressive hearing loss in the ethylnitrosourea-generated mambo mouse line is caused by a mutation in Usp53, a member of the deubiquitinating enzyme family. USP53 contains a catalytically inactive ubiquitin-specific protease domain and is expressed in cochlear hair cells and a subset of supporting cells...
November 25, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Sonia Watson
Mechanotransduction by proprioceptive sensory organs is poorly understood. Evidence was recently shown that muscle spindle and hair follicle primary afferents (lanceolates) constantly release glutamate from synaptic-like vesicles (SLVs) within the terminals. The secreted glutamate activates a highly unusual metabotropic glutamate receptor (mGluR) to modulate the firing rate (spindles) and SLV recycling (lanceolates). This receptor has yet to be isolated and sequenced. To further investigate this receptor's pharmacology, ligands selective for classical mGluRs have been recently characterised for their ability to alter stretch-evoked spindle firing and SLV endocytosis in these different endings...
August 2015: Journal of Anatomy
Shannon Famenini, Carolyn Goh
Currently, topical minoxidil and finasteride are the only treatments that have been FDA approved for the treatment of female pattern hair loss and androgenetic alopecia. Given the incomplete efficacy and sife effect profile of these medications, some patients utilize alternative treatments to help improve this condition. In this review, we illustrate the scientific evidence underlying the efficacy of these alternative approaches, including biotin, caffeine, melatonin, a marine extract, and zinc.
July 2014: Journal of Drugs in Dermatology: JDD
Moo Kyun Park, Gi Jung Im, Jiwon Chang, Sung Won Chae, Jun Yoo, Won-gue Han, Gyu Ho Hwang, Jong Yoon Jung, Jungim Choi, Hak Hyun Jung, Ah-Young Chung, Hae-Chul Park, June Choi
OBJECTIVE: Caffeic acid phenethyl ester (CAPE) is known to reduce the generation of oxygen-derived free radicals, which is a major mechanism of aminoglycoside-induced ototoxicity. The objective of the present study was to evaluate the effects of CAPE on neomycin-induced ototoxicity in zebrafish (Brn3c: EGFP). METHODS: Five-day post-fertilization zebrafish larvae (n=10) were exposed to 125 μM neomycin and one of the following CAPE concentrations for 1h: 50, 100, 250, 500, or 1000 μM...
August 2014: International Journal of Pediatric Otorhinolaryngology
Paul M Forlano, Spencer D Kim, Zuzanna M Krzyminska, Joseph A Sisneros
Although the neuroanatomical distribution of catecholaminergic (CA) neurons has been well documented across all vertebrate classes, few studies have examined CA connectivity to physiologically and anatomically identified neural circuitry that controls behavior. The goal of this study was to characterize CA distribution in the brain and inner ear of the plainfin midshipman fish (Porichthys notatus) with particular emphasis on their relationship with anatomically labeled circuitry that both produces and encodes social acoustic signals in this species...
September 1, 2014: Journal of Comparative Neurology
Qin Jia, Min Zhang, Yanan Kong, Shixuan Chen, Yinghua Chen, Xueer Wang, Lei Zhang, Weiya Lang, Lu Zhang, Lin Zhang
Activin B has been reported to promote the regeneration of hair follicles during wound healing. However, its role in the development and life cycle of hair follicles has not been elucidated. In our study, the effect of activin B on mouse hair follicles of cultured and neonatal mouse skin was investigated. In these models, PBS or activin B (5, 10 or 50 ng/ml) was applied, and hair follicle development was monitored. Hair follicle initiation and development was examined using hematoxylin and eosin staining, alkaline phosphatase activity staining, Oil Red O+ staining, and the detection of TdT-mediated dUTP-biotin nick end-labeling cell apoptosis...
2013: Cells, Tissues, Organs
Jiwon Chang, Gi Jung Im, Sung Won Chae, Seung Hoon Lee, Soon-Young Kwon, Hak Hyun Jung, Ah-Young Chung, Hae-Chul Park, June Choi
OBJECTIVES: Trimetazidine (TMZ) is known to reduce the generation of oxygen-derived free radicals. The objective of the present study was to evaluate the effects of TMZ on neomycin-induced ototoxicity in transgenic zebrafish (Brn3C: EGFP). METHODS: Five-day, postfertilization zebrafish larvae were exposed to 125 µM neomycin and one of the following TMZ concentrations for 1 hour: 10 µM, 100 µM, 500 µM, 1,000 µM, 1,500 µM, or 2,000 µM. Hair cells within the neuromasts of the supraorbital (SO1 and SO2), otic (O1), and occipital (OC1) lateral lines were analyzed using fluorescence microscopy and confocal microscopy (n=10)...
December 2013: Clinical and Experimental Otorhinolaryngology
Lijuan Shi, Yuxiang An, Aimei Wang, Qinghua Gao, Yu Yang
OBJECTIVE: The clinical use of aminoglycoside antibiotics is limited in most countries because of auditory toxicity side effects. However, their use is common in developing countries because they are inexpensive and convenient. Salvia miltiorrhiza extracts are used clinically in China for their antioxidant properties. We investigated the effect of a clinically approved injectable S. miltiorrhiza solution on inducible nitric oxide synthase (iNOS) generation induced by the aminoglycoside antibiotic gentamicin and an ototoxicity protective mechanism...
March 2014: American Journal of Otolaryngology
Jae-Jun Song, Jiwon Chang, Jungim Choi, Gi Jung Im, Sung Won Chae, Seung Hoon Lee, Soon-Young Kwon, Hak Hyun Jung, Ah-Young Chung, Hae-Chul Park, June Choi
NecroX-5, one of the derivatives of NecroX series compounds, is a mitochondrial reactive oxygen species and reactive nitrogen species scavenger that inhibits cell death against various kinds of oxidative stresses. The objective of the present study was to evaluate the effects of NecroX-5 on neomycin-induced ototoxicity in transgenic zebrafish (Brn3C: EGFP). Five days post-fertilization, zebrafish larvae were exposed to 125 μM neomycin and one of the following NecroX-5 concentrations for 1 h: 10, 25, 50, and 75 μM...
February 2014: Archives of Toxicology
Masahiro Yuasa, Tomoyoshi Matsui, Saori Ando, Yoshie Ishii, Hiromi Sawamura, Shuhei Ebara, Toshiaki Watanabe
OBJECTIVE: Biotin is a water-soluble vitamin that acts as a cofactor for several carboxylases. The ketogenic diet, a low-carbohydrate, high-fat diet, is used to treat drug-resistant epilepsy and promote weight loss. In Japan, the infant version of the ketogenic diet is known as the "ketone formula." However, as the special infant formulas used in Japan, including the ketone formula, do not contain sufficient amounts of biotin, biotin deficiency can develop in infants who consume the ketone formula...
October 2013: Nutrition
Viswanathan Venkataraman, Padma Balaji, Debasis Panigrahi, Rafat Jamal
This study reports the clinical, laboratory profile and outcome in seven patients with biotinidase deficiency. The serum biotinidase activity was assayed using spectrophotometric analysis. The age at presentation varied from day 1 of life to the 5 th month. Seizures were the presenting complaint in six patients and clonic seizures were the predominant seizure type. Sparse hair was seen in four patients, while three did not have any cutaneous manifestation. None of the patients had acidosis or hyperammonemia...
July 2013: Neurology India
Gowri Nayak, Sue I Lee, Rizwan Yousaf, Stephanie E Edelmann, Claire Trincot, Christina M Van Itallie, Ghanshyam P Sinha, Maria Rafeeq, Sherri M Jones, Inna A Belyantseva, James M Anderson, Andrew Forge, Gregory I Frolenkov, Saima Riazuddin
The two compositionally distinct extracellular cochlear fluids, endolymph and perilymph, are separated by tight junctions that outline the scala media and reticular lamina. Mutations in TRIC (also known as MARVELD2), which encodes a tricellular tight junction protein known as tricellulin, lead to nonsyndromic hearing loss (DFNB49). We generated a knockin mouse that carries a mutation orthologous to the TRIC coding mutation linked to DFNB49 hearing loss in humans. Tricellulin was absent from the tricellular junctions in the inner ear epithelia of the mutant animals, which developed rapidly progressing hearing loss accompanied by loss of mechanosensory cochlear hair cells, while the endocochlear potential and paracellular permeability of a biotin-based tracer in the stria vascularis were unaltered...
September 2013: Journal of Clinical Investigation
Yüksel Olgun, Günay Kırkım, Efsun Kolatan, Müge Kıray, Alper Bagrıyanık, Aybüke Olgun, Deniz Cakır Kızmazoglu, Hülya Ellıdokuz, Bulent Serbetcıoglu, Zekiye Altun, Safiye Aktas, Osman Yılmaz, Enis Alpin Günerı
OBJECTIVES/HYPOTHESIS: Our objectives were to study effects of orally administered resveratrol (RV) against cisplatin (CDDP) ototoxicity in different doses and to investigate ultrastructural changes in the cochlea and brainstem. STUDY DESIGN: In vivo study using an animal model. METHODS: Thirty-two male Wistar albino rats were divided into six groups. Baseline distortion product otoacoustic emissions (DPOAEs) and auditory brainstem response (ABR) measurements were made...
March 2014: Laryngoscope
Seok Jin Hong, Gi Jung Im, Jiwon Chang, Sung Won Chae, Seung Hoon Lee, Soon Young Kwon, Hak Hyun Jung, Ah Young Chung, Hae Chul Park, June Choi
OBJECTIVE: Edaravone is known to have a potent free radical scavenging effect. The objective of the present study was to evaluate the effects of edaravone on cisplatin-induced ototoxicity in transgenic zebrafish (Brn3C: EGFP). METHODS: Five day post-fertilization zebrafish larvae were exposed to 1000 μM cisplatin and 50 μM, 100 μM, 250 μM, 500 μM, 750 μM, and 1000 μM concentrations of edaravone for 4h. Hair cells within neuromasts of the supraorbital (SO1 and SO2), otic (O1), and occipital (OC1) lateral lines were analyzed by fluorescence microscopy and confocal microscopy (n=10)...
June 2013: International Journal of Pediatric Otorhinolaryngology
Lena Lünnemann, Annika Vogt, Ulrike Blume-Peytavi, Natalie Garcia Bartels
No abstract text is available yet for this article.
March 2013: JAMA Dermatology
Thomas G Landry, James B Fallon, Andrew K Wise, Robert K Shepherd
Cochlear implants restore hearing cues in the severe-profoundly deaf by electrically stimulating spiral ganglion neurons (SGNs). However, SGNs degenerate following loss of cochlear hair cells, due at least in part to a reduction in the endogenous neurotrophin (NT) supply, normally provided by hair cells and supporting cells of the organ of Corti. Delivering exogenous NTs to the cochlea can rescue SGNs from degeneration and can also promote the ectopic growth of SGN neurites. This resprouting may disrupt the cochleotopic organization upon which cochlear implants rely to impart pitch cues...
August 15, 2013: Journal of Comparative Neurology
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