Zhouxun Chen, Tarek Mustafa, Bogusz Trojanowicz, Michael Brauckhoff, Oliver Gimm, Cornelia Schmutzler, Josef Köhrle, Hans-Jürgen Holzhausen, Astrid Kehlen, Thomas Klonisch, Rainer Finke, Henning Dralle, Cuong Hoang-Vu
CD82 (KAI1) and CD63 (ME491) are highly glycosylated proteins which belong to the transmembrane 4 superfamily (TM4SF). CD82 has been implicated as a possible prostate cancer metastasis suppressor gene, whereas CD63 is involved in the progression of human melanoma cancer. Down-regulation of both CD82 and CD63 expression has been associated with the metastatic potential of several solid tumors. Currently, information is lacking on the role of CD82 and CD63 during thyroid carcinogenesis. The aim of this study was to determine whether the expression of CD82 and CD63 is a useful prognostic indicator in patients with thyroid carcinoma...
October 2004: International Journal of Molecular Medicine