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https://www.readbyqxmd.com/read/29765443/management-of-cardiac-hemochromatosis
#1
Wilbert S Aronow
Iron-overload syndromes may be hereditary or acquired. Patients may be asymptomatic early in the disease. Once heart failure develops, there is rapid deterioration. Cardiac hemochromatosis is characterized by a dilated cardiomyopathy with dilated ventricles, reduced ejection fraction, and reduced fractional shortening. Deposition of iron may occur in the entire cardiac conduction system, especially the atrioventricular node. Cardiac hemochromatosis should be considered in any patient with unexplained heart failure...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29753673/prevalence-and-prognostic-significance-of-malnutrition-using-3-scoring-systems-among-outpatients-with-heart-failure-a-comparison-with-body-mass-index
#2
Shirley Sze, Pierpaolo Pellicori, Syed Kazmi, Alan Rigby, John G F Cleland, Kenneth Wong, Andrew Lawrence Clark
OBJECTIVES: The authors sought to report the prevalence, clinical associations, and prognostic consequences of malnutrition in outpatients with heart failure (HF). BACKGROUND: Malnutrition may be common in HF and associated with adverse outcomes, but few data exist. METHODS: We applied the geriatric nutritional risk index (GNRI), controlling nutritional status (CONUT) score, and prognostic nutritional index (PNI) to consecutive patients referred with suspected HF to a clinic serving a local population (n = 550,000)...
May 2, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29734153/clinical-impact-of-left-ventricular-diastolic-dysfunction-in-chronic-kidney-disease
#3
Tetsuya Ogawa, Kosaku Nitta
Left ventricular diastolic dysfunction (LVDD) frequently occurs in chronic kidney disease (CKD) and is associated with heart failure and higher mortality. LVDD is observed in patients with early stages of CKD and is associated with cardiovascular events, in patients undergoing incident hemodialysis in the absence of systolic function. The pathogenesis of CKD includes abnormal ventricular filling in diastole and a higher LV filling pressure (LVFP) because of LV hypertrophy (LVH), in addition to myocardial interstitial fibrosis...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29707413/end-stage-renal-failure-is-an-independent-risk-factor-for-1-year-mortality-after-hip-fracture-surgery
#4
Louise Woon Theng Lo, Xu Yanling, Andrew Chia Chen Chou, Tet Sen Howe, John Carson Allen, Joyce Suang Bee Koh
Introduction: End-stage renal failure (ESRF) with its associated comorbidities increase postoperative mortality in hip fracture patients. This study investigated the association of ESRF with various comorbidities in patients on dialysis and assessed rates ESRF as an independent risk factor for all-cause postoperative 1- year mortality rates. Methods: This was a retrospective cohort study on patients aged 55 years and older who underwent their first nonpathological, low-energy hip fracture surgery at an Asian tertiary hospital from June 2007 to 2012...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29704619/factors-associated-with-adherence-to-14-day-office-appointments-after-heart-failure-discharge
#5
Karen Distelhorst, Renee Claussen, Kelly Dion, James F Bena, Shannon L Morrison, Donna Walker, Hua-Li Tai, Nancy M Albert
BACKGROUND: Follow-up within 14 days after hospital discharge for heart failure (HF) may prevent 30-day hospital readmission, but adherence varies. The purpose of this study was to determine predictors of non-adherence to scheduled appointments. METHODS AND RESULTS: A medical record review included patients hospitalized for decompensated HF at 3 health system hospitals, and who had a scheduled 14-day office appointment. Patient demographics, and social, HF and hospital factors were studied for association with appointment adherence...
April 25, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29703552/incidence-and-predictors-of-30-day-readmissions-in-patients-hospitalized-with-chronic-pancreatitis-a-nationwide-analysis
#6
Rushikesh Shah, Christopher Haydek, Ramzi Mulki, Emad Qayed
BACKGROUND: Patients with chronic pancreatitis are prone to frequent readmissions. The aim of this study is to evaluate the rate and predictors of 30-day readmissions in patients with chronic pancreatitis using the Nationwide Readmission Database (NRD). METHODS: We performed a retrospective analysis of all adult patients with the principal discharge diagnosis of chronic pancreatitis from 2010 through 2014. We excluded patients who died during the hospitalization...
April 23, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29675620/management-of-anemia-in-low-risk-myelodysplastic-syndromes-treated-with-erythropoiesis-stimulating-agents-newer-and-older-agents
#7
REVIEW
Roberto Castelli, Riccardo Schiavon, Valentina Rossi, Giorgio Lambertenghi Deliliers
The myelodysplastic syndromes (MDSs) are clonal hematopoietic stem cell disorders. The International Prognostic Score System (IPSS) groups MDS in lower-risk (IPSS low and intermediate-1) and higher-risk disease (IPSS intermediate-2 and high). AML transformation is the main concern in higher-risk MDS, while anemia and transfusion dependency represent the major issues for low-risk MDS patients. Improving erythropoiesis, and eliminating fatigue and symptoms, is the main therapeutic goal for low-risk MDS patients...
April 19, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29667019/what-is-new-in-heart-failure-management-in-2017-update-on-acc-aha-heart-failure-guidelines
#8
REVIEW
Biykem Bozkurt
PURPOSE OF REVIEW: The goal of this paper is to provide a summary of the new recommendations in the most recent 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. The intent is to provide the background and the supporting evidence for the recommendations and to provide practical guidance for management strategies in treatment of heart failure patients...
April 17, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29657589/prognostic-significance-of-nonsustained-ventricular-tachycardia-in-patients-receiving-cardiac-resynchronization-therapy-for-primary-prevention-analysis-of-the-japan-cardiac-device-treatment-registry-database
#9
Hisashi Yokoshiki, Akihiko Shimizu, Takeshi Mitsuhashi, Hiroshi Furushima, Yukio Sekiguchi, Tetsuyuki Manaka, Nobuhiro Nishii, Takeshi Ueyama, Norishige Morita, Hideo Okamura, Takashi Nitta, Kenzo Hirao, Ken Okumura
Background: Whether nonsustained ventricular tachycardia (NSVT) is a marker of increased risk of sustained ventricular tachyarrhythmias (VTAs) remains to be established in patients receiving cardiac resynchronization therapy with a defibrillator (CRT-D) for primary prevention. Methods: Among the follow-up data of the Japan cardiac device treatment registry (JCDTR) with an implantation date between January 2011 and August 2015, information regarding a history of NSVT before the CRT-D implantation for primary prevention had been registered in 269 patients...
April 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29652187/blood-transfusion-during-total-ankle-arthroplasty-is-associated-with-increased-in-hospital-complications-and-costs
#10
Michael A Ewing, Samuel R Huntley, Dustin K Baker, Kenneth S Smith, Parke W Hudson, Gerald McGwin, Brent A Ponce, Michael D Johnson
INTRODUCTION: Total ankle arthroplasty (TAA) is an increasingly used, effective treatment for end-stage ankle arthritis. Although numerous studies have associated blood transfusion with complications following hip and knee arthroplasty, its effects following TAA are largely unknown. This study uses data from a large, nationally representative database to estimate the association between blood transfusion and inpatient complications and hospital costs following TAA. METHODS: Using the Nationwide Inpatient Sample (NIS) database from 2004 to 2014, 25 412 patients who underwent TAA were identified, with 286 (1...
April 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29622977/clinical-and-laboratory-characteristics-of-short-term-mortality-in-egyptian-patients-with-acute-heart-failure
#11
Ahmad Tageldien Abdellah, Alaa Desouky Mohamed, Hamdy Ali Hendawi, Magdi Ali Omera
Objective: To identify the clinical and laboratory predictors of short-term mortality in patients with acute heart failure (AHF). Subjects and methods: We conducted a prospective, single center study on 120 consecutive patients presented with acute heart failure to the emergency department. All patients had clinical, laboratory, electrocardiographic and echocardiographic evaluation. Short-term mortality was reported within 30 days of presentation. Results: Mean age was 59...
September 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29617510/symptomatic-aortic-paravalvular-leak-percutaneous-treatment-with-amplatzer-vascular-plug-iii-device-as-an-alternative-to-surgery
#12
Gabriel E Pérez Baztarrica, Gastón Heredia, Juan Arellano, Juan Fernández, Rafael Porcile
A significant prosthetic paravalvular leak is an uncommon and severe postsurgical complication correlated to the occurrence of congestive heart failure and hemolytic anemia. Percutaneous treatment has become an attractive and effective proposal to relieve symptoms and reduce complications in patients whose high rate of morbidity/mortality precludes a new surgery. This is the case of an 81-year-old patient with a history of biological aortic valve replacement seeking medical help due to heart failure and hemolytic anemia, with a prosthetic paravalvular regurgitation jet and high surgical mortality according to EuroSCORE II...
January 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29597053/associations-with-and-prognostic-and-discriminatory-role-of-n-terminal-pro-b-type-natriuretic-peptide-in-heart-failure-with-preserved-vs-mid-range-vs-reduced-ejection-fraction
#13
Gianluigi Savarese, Nicola Orsini, Camilla Hage, Ulf Dahlström, Ola Vedin, Giuseppe M C Rosano, Lars H Lund
BACKGROUND: Aim was to characterize N-terminal pro-B-type natriuretic peptide (NT-proBNP) in terms of determinants of levels and of its prognostic and discriminatory role in heart failure with mid-range (HFmrEF) vs. preserved (HFpEF) and reduced (HFrEF) ejection fraction. METHODS AND RESULTS: In 9,847 out-patients with HFpEF (n=1,811;18%), HFmrEF (n=2,122;22%) and HFrEF (n=5,914;60%) enrolled in the Swedish Heart Failure Registry, median NT-proBNP was 1,428, 1,540 and 2,288 pg/ml, respectively...
March 26, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29566812/transcatheter-aortic-valve-replacement-in-patients-with-low-flow-low-gradient-aortic-stenosis-the-topas-tavi-registry
#14
Henrique Barbosa Ribeiro, Stamatios Lerakis, Martine Gilard, João L Cavalcante, Raj Makkar, Howard C Herrmann, Stephan Windecker, Maurice Enriquez-Sarano, Asim N Cheema, Luis Nombela-Franco, Ignacio Amat-Santos, Antonio J Muñoz-García, Bruno Garcia Del Blanco, Alan Zajarias, John C Lisko, Salim Hayek, Vasilis Babaliaros, Florent Le Ven, Thomas G Gleason, Tarun Chakravarty, Wilson Y Szeto, Marie-Annick Clavel, Alberto de Agustin, Vicenç Serra, John T Schindler, Abdellaziz Dahou, Rishi Puri, Emilie Pelletier-Beaumont, Melanie Côté, Philippe Pibarot, Josep Rodés-Cabau
BACKGROUND: Few data exist on patients with low-flow, low-gradient aortic stenosis (LFLG-AS) undergoing transcatheter aortic valve replacement (TAVR). Also, very scarce data exist on the usefulness of dobutamine stress echocardiography (DSE) before TAVR in these patients. OBJECTIVES: The authors sought to evaluate clinical outcomes and changes in left ventricular ejection fraction (LVEF) following TAVR in patients with classical LFLG-AS. METHODS: This multicenter registry included 287 patients with LFLG-AS undergoing TAVR...
March 27, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29562736/pre-discharge-anemia-as-a-predictor-of-adverse-clinical-outcomes-in-patients-with-acute-decompensated-heart-failure
#15
Min Chul Kim, Kye Hun Kim, Jae Yeong Cho, Ki Hong Lee, Doo Sun Sim, Hyun Ju Yoon, Nam Sik Yoon, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park
Background/Aims: The impact of the timing of anemia during hospitalization on future clinical outcomes after surviving discharge from an index heart failure (HF) has been poorly studied in patients with acute decompensated heart failure (ADHF). Methods: A total of 384 surviving patients with acute ADHF were divided into two groups: an anemia group (n = 270, 199 anemia at admission and 71 pre-discharge anemia) and a no anemia group (n = 114). All-cause mortality and HF re-hospitalization were compared between groups...
March 23, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29548288/relationship-between-high-density-lipoprotein-cholesterol-and-the-red-cell-distribution-width-in-patients-with-coronary-artery-disease
#16
Eyup Avci, Tuncay Kiris, Abdullah Orhan Demirtas, Hasan Kadi
BACKGROUND: The red cell distribution width (RDW) is a numerical measurement of variability in the size of red blood cells. Many studies have shown that high-density lipoprotein cholesterol (HDL-C), has an anti-inflammatory effect. The aim of this study was to investigate the relationship between the serum HDL-C level and RDW in patients with coronary artery disease (CAD). METHODS: Patients who underwent coronary angiography were reviewed. Patients who had moderate or severe heart failure, moderate or severe renal failure, significant systemic disease, anemia, a blood transfusion within the last 3 months, or a hematologic disease, as well as those who were taking lipid-lowering medication, were excluded from the study...
March 16, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29543671/iron-overload-cardiomyopathy-from-diagnosis-to-management
#17
Carles Díez-López, Josep Comín-Colet, José González-Costello
PURPOSE OF REVIEW: Iron overload cardiomyopathy (IOC) is an important predictor of prognosis in a significant number of patients with hereditary hemochromatosis and hematologic diseases. Its prevalence is increasing because of improved treatment strategies, which significantly improve life expectancy. We will review diagnosis, treatment, and recent findings in the field. RECENT FINDINGS: The development of preclinical translational disease models during the last years have helped our understanding of specific disease pathophysiological pathways that might eventually change the outcomes of these patients...
March 14, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29538209/the-safety-of-endothelin-receptor-antagonists-in-the-treatment-of-pulmonary-arterial-hypertension-protocol-for-a-systemic-review-and-network-meta-analysis
#18
REVIEW
Zhi-Chun Gu, Yi-Jing Zhang, Mang-Mang Pan, Chi Zhang, Xiao-Yan Liu, An-Hua Wei, Ying-Jie Su
BACKGROUND: Pulmonary arterial hypertension (PAH) is a progressive disease and ultimately leads to right heart failure. Endothelin receptor antagonists (ERAs) have been demonstrated to significantly improve prognosis in PAH. However, ERAs-induced side effects can result in poor patient tolerance. Thus, we aim to evaluate current safety evidence of ERAs in PAH. METHODS: An electronic search will be performed for randomized controlled trials (RCTs) that reported the interested safety data (abnormal liver function, peripheral edema, and anemia) of ERAs in PAH...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29532755/homocysteine-and-hyperhomocysteinaemia
#19
Bozidarka L Zaric, Milan Obradovic, Vladan Bajic, Mohamed A Haidara, Milos Jovanovic, Esma R Isenovic
Homocysteine (Hcy) is thiol group containing the amino acid, which naturally occurs in all humans. Hcy is degraded in the body through two metabolic pathways, while a minor part is excreted through kidneys. The chemical reactions that are necessary for degradation of Hcy require the presence of the folic acid, vitamins B6 and B12. Consequently, the level of the total Hcy in the serum is influenced by the presence or absence of these vitamins. An elevated level of the Hcy, hyperhomocysteinemia (HHcy) and homocystinuria are connected with occlusive artery disease, especially in the brain, the heart, and the kidney, in addition to venous thrombosis, chronic renal failure, megaloblastic anemia, osteoporosis, depression, Alzheimer's disease, pregnancy problems, and others...
March 12, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29512626/iron-deficiency-and-hematinic-deficiencies-in-atrial-fibrillation-a-new-insight-into-comorbidities
#20
Muhammed Keskin, Dilek Ural, Servet Altay, Onur Argan, Edibe Betül Börklü, Ömer Kozan
OBJECTIVE: Iron deficiency (ID) is the most common nutritional deficiency, and iron metabolism becomes further deteriorated in the presence of certain conditions, such as heart failure (HF). Atrial fibrillation (AF) has many similarities to HF, including a chronic inflammatory pathophysiology; however, the prevalence of ID and other hematinic deficiencies in AF patients have not been determined. METHODS: In this study, the prevalence of iron (serum ferritin <100 µg/L or ferritin 100-299 µg/L with transferrin saturation <20%), vitamin B12 (<200 pg/mL), and folate deficiency (<4...
March 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
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