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follicle atresia

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https://www.readbyqxmd.com/read/29349677/mercuric-chloride-induced-ovarian-oxidative-stress-by-suppressing-nrf2-keap1-signal-pathway-and-its-downstream-genes-in-laying-hens
#1
Yan Ma, Mingkun Zhu, Liping Miao, Xiaoyun Zhang, Xinyang Dong, Xiaoting Zou
The present study evaluated the effects of mercury chloride (HgCl2) on follicular atresia rate, sex hormone secretion, and ovarian oxidative stress in laying hens. Antioxidant enzyme genes and the nuclear factor erythroid 2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) signal pathway were further studied to uncover the molecular mechanism. A total of 768 40-week-old Hy-Line Brown laying hens were randomly allocated to four treatments with eight pens per treatment and 24 hens of each pen...
January 18, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29334208/effects-of-crocin-on-the-pituitary-gonadal-axis-and-hypothalamic-kiss-1-gene-expression-in-female-wistar-rats
#2
Dina Zohrabi, Kazem Parivar, Mohammad Hossein Sanati, Nasim Hayati Roodbari
Background: Saffron (Crocus sativus L.) has been traditionally used as a spice for coloring and flavoring in some countries cuisine. One of the main components of saffron is Crocin. Recent research have shown that crocin has various pharmacological effects. The aim of this study was to assess the effects of crocin on the Pituitary-Gonadal axis and Kiss-1 gene expression in hypothalamus and ovarian tissue organization in female Wistar rats. MATERIALS AND METHODS: In this experimental study, 18 adult female Wistar rats were randomly divided into three groups...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29331755/sphingosine-1-phosphate-protects-human-ovarian-follicles-from-apoptosis-in-vitro
#3
Yilmaz Guzel, Gamze Bildik, Ozgur Oktem
OBJECTIVE(S): We aimed to analyze if anti-apoptotic agent sphingosine-1-phosphate offers protection against in vitro follicle atresia during culture of human ovarian cortical samples. STUDY DESIGN: A translational research study of ex-vivo and in-vitro models of human ovarian tissue. MATERIAL AND METHODS: Ovarian cortical tissue fragments (1 × 0.5 cm) were obtained from young patients (n = 15 mean age ± SD: 29.4 ± 2.5) undergoing laparoscopic excision of benign ovarian cysts...
January 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29259464/expression-of-cytokine-induced-neutrophil-chemoattractant-suppresses-tumor-necrosis-factor-alpha-expression-and-thereby-prevents-the-follicles-from-undergoing-atresia-and-apoptosis
#4
Yu Tanaka, Akira Kuwahara, Kenjiro Ushigoe, Yuya Yano, Yuka Taniguchi, Yuri Yamamoto, Toshiya Matsuzaki, Toshiyuki Yasui, Minoru Irahara
Aim: Cytokine-induced neutrophil chemoattractant (CINC/gro) is a CXC family chemokine, similar to interleukin-8 in rats, and is one of the factors that regulates ovulation. However, the mechanism that regulates atresia of the ovaries postovulation is not clearly defined. Methods: Whether antibody-blocking of CINC/gro can alter the number of ovulated oocytes and modulate neutrophil infiltration was investigated. The effect of the antibody on the level of inflammatory cytokine production and follicular atresia was examined...
April 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29258955/evaluation-of-toxicological-endpoints-in-female-zebrafish-after-bisphenol-a-exposure
#5
Ana M Molina, Nieves Abril, Noelia Morales-Prieto, José G Monterde, Antonio J Lora, Nahúm Ayala, Rosario Moyano
Given the importance of bisphenol A (BPA) as a xenoestrogen and its potential effects on human and animal health, we evaluated BPA exposure's short-term effects on follicular development, yolk protein vitellogenin (VTG) production and aromatase expression in female zebrafish. Histological modifications were observed along with increased presence of atretic follicles. Whole-body VTG concentration increased with the dose of BPA exposure. In contrast, expression of Cyp19a mRNA in the ovaries of BPA-exposed fish exhibited an apparent non-monotonic response curve, marked by downregulation at 1 μg/L BPA, upregulation at 10 μg/L BPA, and a return to downregulation at 100 μg/L BPA and higher doses...
December 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29250140/effects-of-dimethyl-carbonate-induced-autophagic-activation-on-follicular-development-in-the-mouse-ovary
#6
Zonghao Tang, Zhenghong Zhang, Yedong Tang, Lingbin Qi, Fafu Yang, Zhengchao Wang
Dimethyl carbonate (DMC) is a widely used industrial chemical, which may be increasingly used in the future. However, its toxicity profile remains largely unknown. The present study was designed to investigate the effects of DMC exposure on the ovaries and the effect of autophagy activation on follicular development. Rats were randomly divided into a control group and low, medium and high dose DMC groups (all n=10). Histological analyses identified no marked differences in the rate of apoptosis between the control and low dose groups; however, marked apoptosis occurred in the medium and high dose groups...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29247838/a-retrospective-analysis-of-adverse-effects-of-an-in-vivo-fluoroquinolone-antibiotic-enrofloxacin-treatment-on-oocyte-quality-in-the-common-marmoset
#7
O Y Tkachenko, J U Scheerer-Bernhard, S Delimitreva, E Wedi, R R Valle, M Heistermann, P L Nayudu
Here we report a retrospective analysis of negative effects of routine enrofloxacin treatment of recurrent diarrhea on the ovary and the developing oocytes of the common marmoset, a small New World primate. The most deleterious effect on oocytes was observed about two months post treatment suggesting that the enrofloxacin effect is on early growing follicles. Manifestations of toxicity included decreased numbers of growing follicles and recovered culturable oocytes, as well as signs of early atresia of granulosa cells...
December 13, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/29232906/histology-of-the-ovary-of-the-laying-hen-gallus-domesticus
#8
K Denise Apperson, Karyn E Bird, Gita Cherian, Christiane V Löhr
The laying hen (Gallus domesticus) is a robust animal model for epithelial ovarian cancer. The use of animal models is critical in identifying early disease markers and developing and testing chemotherapies. We describe the microscopic characteristics of the normally functioning laying hen ovary and proximal oviduct to establish baselines from which lesions associated with ovarian cancer can be more readily identified. Ovaries and oviducts were collected from 18-month-old laying hens (n = 18) and fixed in 10% neutral buffered formalin...
December 11, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29229882/igf1-stimulates-differentiation-of-primary-follicles-and-their-growth-in-ovarian-explants-of-zebrafish-danio-rerio-cultured-in-vitro
#9
Pancharatna A Katti, Sheetal S Narvekar, Basavaraj B Goundadkar, Prasad A Deshpande
The present study is an attempt to elucidate the involvement of insulin-like growth factor (IGF1) in the differentiation and growth of primary follicles in ovarian explant cultures of zebrafish. Ovaries from adult females were cultured in triplicate sets/treatment group for 15 days at 22° in the laboratory. Culture medium was supplemented with either insulin (1 ng/mL) or IGF1 (1 ng/mL) or insulin + IGF1 (Experiment 1) or 0.1 or 1.0 or 10 ng/mL of IGF1 (Experiment 2). Ovaries cultured in medium alone served as controls and those fixed at the beginning of the culture as initial controls...
December 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/29207291/transcriptome-analysis-of-ovine-granulosa-cells-reveals-differences-between-small-antral-follicles-collected-during-the-follicular-and-luteal-phases
#10
Reza Talebi, Ahmad Ahmadi, Fazlollah Afraz, Julien Sarry, Florence Plisson-Petit, Carine Genêt, Stéphane Fabre
Ovarian follicular growth occurs in both the follicular and luteal phases of the estrous cycle but in very different endocrine contexts. In both phases, many small antral follicles with similar morphologic and histologic characteristics are present within the ovaries as a reserve for the terminal folliculogenesis. However, there are several gaps in our molecular knowledge of the gene expression profiles of small antral follicles in the follicular and luteal phases. The aim of the present study was to use RNA sequencing to compare and analyze the global transcriptional profile of ovine granulosa cells collected from small antral follicles (1-3 mm) either during the follicular or the luteal phase of the estrous cycle, with the hypothesis that they should be differential...
November 27, 2017: Theriogenology
https://www.readbyqxmd.com/read/29180824/genetic-architecture-and-candidate-genes-identified-for-follicle-number-in-chicken
#11
Manman Shen, Hongyan Sun, Liang Qu, Meng Ma, Taocun Dou, Jian Lu, Jun Guo, Yuping Hu, Xingguo Wang, Yongfeng Li, Kehua Wang, Ning Yang
Follicular development has a major impact on reproductive performance. Most previous researchers focused on molecular mechanisms of follicular development. The genetic architecture underlying the number of follicle, however, has yet not to be thoroughly defined in chicken. Here we report a genome-wide association study for the genetic architecture determining the numbers of follicles in a large F2 resource population. The results showed heritability were low to moderate (0.05-0.28) for number of pre-ovulatory follicles (POF), small yellow follicles (SYF) and atresia follicles (AF)...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29151191/silica-nanoparticle-exposure-inducing-granulosa-cell-apoptosis-and-follicular-atresia-in-female-balb-c-mice
#12
Jianhui Liu, Man Yang, Li Jing, Lihua Ren, Jialiu Wei, Jin Zhang, Feng Zhang, Junchao Duan, Xianqing Zhou, Zhiwei Sun
Given that the effects of ultrafine fractions (< 0.1 μm) on reproductive diseases are gaining attention, this study aimed to explore the influence of silica nanoparticle (SiNP)-induced female reproductive dysfunction. In this study, 80 female mice were randomly divided into four groups including a control group and three concentrations of SiNP groups (7, 21, 35 mg/kg). Mice were exposed to the vehicle control and silica nanoparticles by tracheal perfusion every 3 days a total of five times in 15 days...
November 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29117655/genetic-etiology-of-primary-premature-ovarian-insufficiency
#13
Maja Franić-Ivanišević, Damir Franić, Miomira Ivović, Milina Tančić-Gajić, Ljiljana Marina, Marija Barac, Svetlana Vujović
Primary premature ovarian insufficiency (PPOI) is characterized by hypergonadotropic amenorrhea and hypoestrogenism in women under 40 years of age. PPOI incidence is 1:10,000 in women aged 18-25, 1:1000 in women aged 25-30 and 1:100 in women aged 35-40. In 10%-28% of cases, PPOI causes primary and in 4%-18% secondary amenorrhea. The process is a consequence of accelerated oocyte atresia, diminished number of germinated cells, and central nervous system aging. Specific genes are responsible for the control of oocyte number undergoing the ovulation process and the time to cessation of the reproductive function...
December 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29097592/low-glucose-availability-stimulates-progesterone-production-by-mouse-ovaries-in-vitro
#14
Kathryn Wilsterman, Aimee Pepper, George E Bentley
Steroid production by the ovary is primarily stimulated by gonadotropins but can also be affected by biological cues that provide information about energy status and environmental stress. To further understand which metabolic cues the ovary can respond to, we exposed gonadotropin-stimulated mouse ovaries in vitro to glucose metabolism inhibitors and measured steroid accumulation in media. Gonadotropin-stimulated ovaries exposed to 2-deoxy-d-glucose increased progesterone production and steroidogenic acute regulatory protein mRNA levels...
December 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29091903/chemoprotective-role-of-ethanol-extract-of-urtica-urens-l-against-the-toxicity-of-imidacloprid-on-endocrine-disruption-and-ovarian-morphometric-in-female-rats-gc-ms-analysis
#15
Massara Mzid, Zohra Ghlissi, Maryem Ben Salem, Sameh Ben Khedir, Khansa Chaabouni, Fatma Ayedi, Zouheir Sahnoun, Ahmed Hakim, Tarek Rebai
Imidacloprid (IMI) is a widely used in Tunisia and abroad, and high doses of IMI have been known to cause endocrine disruption. Some reports claim that Urtica urens L. (UU) can reduce toxicity thanks to it anti-inflammatory and antioxidant activities, but there is no scientific evidence justifying its use, which lets us think to its direct effect on the metabolism of the ovarian tissue. The present study was undertaken to evaluate the protective effect of UU against the toxicity of Confidor(®), whose active substance is imidacloprid (IMI), in female rat, as well as the chemical compositions of UU ethanol (EtOH) extract by GC-MS...
October 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29080194/follicle-dynamics-visualization-and-analysis-of-follicle-growth-and-maturation-using-murine-ovarian-tissue-culture
#16
Tomohiko Murase, Akira Iwase, Kouji Komatsu, Bayasula, Tomoko Nakamura, Satoko Osuka, Sachiko Takikawa, Maki Goto, Tomomi Kotani, Fumitaka Kikkawa
PURPOSE: To visualize and analyze follicle development in ovarian tissue culture using physiological concentrations of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in order to establish an ovarian tissue culture system that enables efficient in vitro growth of follicles. METHODS: Ovarian tissues from 4-week-old female ICR mice were sliced and cultured. Images of ovarian tissues in culture were obtained at 24-h or 30-min intervals by using a microscope...
October 27, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29024988/low-dose-metronomic-delivery-of-cyclophosphamide-is-less-detrimental-to-granulosa-cell-viability-ovarian-function-and-fertility-than-maximum-tolerated-dose-delivery-in-the-mouse
#17
Jacqueline Dynes, Kata Osz, Allyssa Hooper, Jim Petrik
Chemotherapy can cause early menopause or infertility in women and have a profound negative impact on the quality of life of young female cancer survivors. Various factors are known to influence the risk of chemotherapy-induced ovarian failure, including the drug dose and treatment duration; however, the scheduling of dose administration has not yet been evaluated as an independent risk factor. We hypothesized that low-dose metronomic (LDM) chemotherapy scheduling would be less detrimental to ovarian function than the traditional maximum tolerated dose (MTD) strategy...
September 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28927438/activated-ovarian-endothelial-cells-promote-early-follicular-development-and-survival
#18
Alon Kedem, Anate Aelion-Brauer, Peipei Guo, Duancheng Wen, Bi-Sen Ding, Raphael Lis, Du Cheng, Vladislav M Sandler, Shahin Rafii, Zev Rosenwaks
BACKGROUND: New data suggests that endothelial cells (ECs) elaborate essential "angiocrine factors". The aim of this study is to investigate the role of activated ovarian endothelial cells in early in-vitro follicular development. METHODS: Mouse ovarian ECs were isolated using magnetic cell sorting or by FACS and cultured in serum free media. After a constitutive activation of the Akt pathway was initiated, early follicles (50-150 um) were mechanically isolated from 8-day-old mice and co-cultured with these activated ovarian endothelial cells (AOEC) (n = 32), gel (n = 24) or within matrigel (n = 27) in serum free media for 14 days...
September 19, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28924180/%C3%AE-snap-is-expressed-in-mouse-ovarian-granulosa-cells-and-plays-a-key-role-in-folliculogenesis-and-female-fertility
#19
Alexis Arcos, Matilde de Paola, Diego Gianetti, Diego Acuña, Zahady D Velásquez, María Paz Miró, Gabriela Toro, Bryan Hinrichsen, Rosa Iris Muñoz, Yimo Lin, Gonzalo A Mardones, Pamela Ehrenfeld, Francisco J Rivera, Marcela A Michaut, Luis Federico Batiz
The balance between ovarian folliculogenesis and follicular atresia is critical for female fertility and is strictly regulated by a complex network of neuroendocrine and intra-ovarian signals. Despite the numerous functions executed by granulosa cells (GCs) in ovarian physiology, the role of multifunctional proteins able to simultaneously coordinate/modulate several cellular pathways is unclear. Soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (α-SNAP) is a multifunctional protein that participates in SNARE-mediated membrane fusion events...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28914456/ovarian-structure-and-oogenesis-of-the-extremophile-viviparous-teleost-poecilia-mexicana-poeciliidae-from-an-active-sulfur-spring-cave-in-southern-mexico
#20
Aarón Torres-Martínez, Arlette Hernández-Franyutti, Mari Carmen Uribe, Wilfrido Miguel Contreras-Sánchez
The structure of the ovary and oogenesis of Poecilia mexicana from an active sulfur spring cave is documented. Poecilia mexicana is the only poeciliid adapted to a subterranean environment with high hydrogen sulfide levels and extreme hypoxic conditions. Twenty females were captured throughout one year at Cueva del Azufre, located in the State of Tabasco in Southern Mexico. Ovaries were processed with histological techniques. P. mexicana has a single, ovoid ovary with ovigerous lamella that project to the ovarian lumen...
September 15, 2017: Journal of Morphology
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