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https://www.readbyqxmd.com/read/27901103/fsh-protects-mouse-granulosa-cells-from-oxidative-damage-by-repressing-mitophagy
#1
Ming Shen, Yi Jiang, Zhiqiang Guan, Yan Cao, Shao-Chen Sun, Honglin Liu
Oxidative stress has been implicated in triggering granulosa cell (GC) death during follicular atresia. Recent studies suggested that follicle-stimulating hormone (FSH) has a pivotal role in protecting GCs from oxidative injury, although the exact mechanism remains largely unknown. Here, we report that FSH promotes GC survival by inhibiting oxidative stress-induced mitophagy. The loss of GC viability caused by oxidative stress was significantly reduced after FSH treatment, which was correlated with impaired activation of mitophagy upon oxidative stress...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27882941/tgf-%C3%AE-signaling-controls-fshr-signaling-reduced-ovarian-granulosa-cell-apoptosis-through-the-smad4-mir-143-axis
#2
Xing Du, Lifan Zhang, Xinyu Li, Zengxiang Pan, Honglin Liu, Qifa Li
Follicle-stimulating hormone receptor (FSHR) and its intracellular signaling control mammalian follicular development and female infertility. Our previous study showed that FSHR is downregulated during follicular atresia of porcine ovaries. However, its role and regulation in follicular atresia remain unclear. Here, we showed that FSHR knockdown induced porcine granulosa cell (pGC) apoptosis and follicular atresia, and attenuated the levels of intracellular signaling molecules such as PKA, AKT and p-AKT. FSHR was identified as a target of miR-143, a microRNA that was upregulated during porcine follicular atresia...
November 24, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27821562/oxidative-stress-in-granulosa-lutein-cells-from-in-vitro-fertilization-patients
#3
Julio Ávila, Rebeca González-Fernández, Deborah Rotoli, Jairo Hernández, Angela Palumbo
Ovarian aging is associated with gradual follicular loss by atresia/apoptosis. Increased production of toxic metabolites such as reactive oxygen species (ROS) and reactive nitrogen species as well as external oxidant agents plays an important role in the process of ovarian senescence and in the pathogenesis of ovarian pathologies such as endometriosis and polycystic ovary syndrome (PCOS). This review provides a synthesis of available studies of oxidative stress (OS) in the ovary, focusing on the most recent evidence obtained in mural granulosa-lutein (GL) cells of in vitro fertilization patients...
December 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27821561/the-ovarian-renin-angiotensin-system-ovras-a-major-factor-in-ovarian-function-and-disease
#4
Angela Palumbo, Julio Ávila, Frederick Naftolin
This contribution summarizes the pivotal role of the ovarian renin-angiotensin system (OVRAS) in ovarian physiology and disease, with particular emphasis on human clinical implications and established translational applications. The presence of a complete OVRAS in all studied species has been known for decades. The OVRAS has major effects on follicle development/atresia and ovulation and steroid hormone secretion, that is, it is necessary for normal reproduction. It is well established that OVRAS activity is regulated by gonadotropins and depends on activation of proteases in the area of growing follicles...
December 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27761969/the-possible-fat1-mediated-apoptotic-pathways-in-porcine-cumulus-cells
#5
Xinhui Wu, Yao Fu, Xulei Sun, Chang Liu, Menglong Chai, Chengzhen Chen, Lisheng Dai, Yan Gao, Hao Jiang, Jiabao Zhang
Porcine cumulus cells are localized around oocytes and act as a specific type of granulosa that plays essential roles in the development and maturation of oocytes, the development and atresia of follicles and the development of embryos. Studies of FAT1 have demonstrated its functions in cell-cell contact, actin dynamics, and cell growth suppression. To understand whether the FAT1 gene affects the apoptosis of porcine cumulus cells and to elucidate the mechanism of this potential action, FAT1 was knocked down using RNA interference...
October 20, 2016: Cell Biology International
https://www.readbyqxmd.com/read/27752308/characterization-of-blood-flow-and-the-effects-of-exogenous-estradiol-benzoate-on-residual-follicles-formed-after-ultrasound-guided-transvaginal-follicle-aspiration-in-cattle
#6
Alberto Mansur Ghetti, Luiz Gustavo Bruno Siqueira, Eduardo Kenji Nunes Arashiro, Miller Pereira Palhao, Felipe Zandonadi Brandao, Joao Henrique Moreira Viana
BACKGROUND: Removal of the follicular content by ultrasound-guided transvaginal follicle aspiration (TVFA) may fail to induce immediate atresia and loss of function, resulting in the occurrence of residual follicles (RF). The aims of this study were to characterize the blood flow in RF and to determine the effects of the treatment with estradiol benzoate on RF fate. Lactating, cyclic Holstein-Gir crossbred cows were used. In Experiment 1, follicular wave emergence (D0) was synchronized in cows (n = 10) and follicular growth was then monitored by transrectal ultrasonography from D0 to D8, followed by TVFA of the largest follicle present on the ovaries 24 h later...
2016: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/27746409/an-immortalized-steroidogenic-goat-granulosa-cell-line-as-a-model-system-to-study-the-effect-of-the-endoplasmic-reticulum-er-stress-response-on-steroidogenesis
#7
Diqi Yang, Lei Wang, Pengfei Lin, Tingting Jiang, Nan Wang, Fan Zhao, Huatao Chen, Keqiong Tang, Dong Zhou, Aihua Wang, Yaping Jin
With granulosa and theca cells, the ovaries are responsible for producing oocytes and secreting sex steroids such as estrogen and progesterone. Endoplasmic reticulum stress (ERS) plays an important role in follicle atresia and embryo implantation. In this study, goat granulosa cells were isolated from medium-sized (4-6 mm) healthy follicles. Primary granulosa cells were immortalized by transfection with human telomerase reverse transcriptase (hTERT) to establish a goat granulosa cell line (hTERT-GGCs). These hTERT-GGCs expressed hTERT and had relatively long telomeres at passage 50...
October 15, 2016: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/27734466/timecourse-of-oocyte-development-in-saithe-pollachius-virens
#8
J E Skjaeraasen, J A Devine, J A Godiksen, M Fonn, H OtterÅ, O S Kjesbu, B Norberg, Ø Langangen, Ø Karlsen
Wild caught North Sea saithe Pollachius virens were monitored for growth, sex steroid profiles and oocyte development pre-spawning and measured for egg size and group fecundity during the spawning season in the laboratory. Vitellogenesis commenced in late October-early November, at a leading cohort size (CL ) of c. 250 µm, after which oocytes grew rapidly in size until spawning started in February. Notably, a distinct cortical alveoli stage was virtually absent with yolk granules observed in developing oocytes at the very beginning of vitellogenesis...
October 13, 2016: Journal of Fish Biology
https://www.readbyqxmd.com/read/27708774/effects-of-chronic-heat-stress-on-granulosa-cell-apoptosis-and-follicular-atresia-in-mouse-ovary
#9
Jieyun Li, Hui Gao, Zhen Tian, Yi Wu, Yingzheng Wang, Yuan Fang, Lu Lin, Ying Han, Shuaishuai Wu, IhteshamUl Haq, Shenming Zeng
BACKGROUND: Heat stress is known to alter follicular dynamics and granulosa cell function and may contribute to the diminished reproductive efficiency commonly observed in mammals during the summer. Although several investigators have studied heat-induced ovarian injury, few reports have focused on the effects of chronic heat stress on ovarian function and the molecular mechanisms through which it induces ovarian injury. METHODS: In Exp. 1, 48 female mice were assigned to a control or heat-stressed treatment...
2016: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/27664382/a-mirna-target-network-putatively-involved-in-follicular-atresia
#10
F X Donadeu, B T Mohammed, J Ioannidis
In a previous microarray study, we identified a subset of micro RNAS (miRNAs), which expression was distinctly higher in atretic than healthy follicles of cattle. In the present study, we investigated the involvement of those miRNAs in granulosa and theca cells during atresia. Reverse Transcription-quantitative Polymerase Chain Reaction (RT-qPCR) confirmed that miR-21-5p/-3p, miR-150, miR-409a, miR-142-5p, miR-378, miR-222, miR-155, and miR-199a-5p were expressed at higher levels in atretic than healthy follicles (9-17 mm, classified based on steroidogenic capacity)...
January 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27621248/smoking-alcohol-and-caffeine-in-relation-to-two-hormonal-indicators-of-ovarian-age-during-the-reproductive-years
#11
J Kline, A Tang, B Levin
OBJECTIVE: To examine whether or not cigarette smoking, alcohol and caffeine intake are related to two indicators of ovarian age-anti-Müllerian hormone (AMH) and follicle stimulating hormone (FSH). STUDY DESIGN: Cross-sectional study of 477 women with a recent index spontaneous abortion (SA) (105 trisomic, 93 non-trisomic) or livebirth (LB) (279) with hormones measured on days 2-4 of an apparently normal menstrual cycle after the index pregnancy. RESULTS: Current smoking is associated with about a 15% increase in median FSH (β for ln(FSH)=0...
October 2016: Maturitas
https://www.readbyqxmd.com/read/27569271/altered-state-of-primordial-follicles-in-neonatal-and-early-infantile-rats-due-to-maternal-hypothyroidism-light-and-electron-microscopy-approach
#12
Jelena Danilović Luković, Aleksandra Korać, Ivan Milošević, Tijana Lužajić, Nela Puškaš, Milica Kovačević Filipović, Anita Radovanović
Thyroid hormones (TH) are one of the key factors for normal prenatal development in mammals. Previously, we showed that subclinical maternal hypothyroidism leads to premature atresia of ovarian follicles in female rat offspring in the pre-pubertal and pubertal periods. The influence of decreased concentration of TH on primordial follicles pool formation during neonatal and early infantile period of rat pups was not investigated previously. Maternal hypothyroidism during pregnancy has irreversible negative influence on primordial follicles pool formation and population of resting oocytes in female rat offspring...
November 2016: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/27562289/ovarian-ageing-the-role-of-mitochondria-in-oocytes-and-follicles
#13
Pascale May-Panloup, Lisa Boucret, Juan-Manuel Chao de la Barca, Valérie Desquiret-Dumas, Véronique Ferré-L'Hotellier, Catherine Morinière, Philippe Descamps, Vincent Procaccio, Pascal Reynier
BACKGROUND: There is a great inter-individual variability of ovarian ageing, and almost 20% of patients consulting for infertility show signs of premature ovarian ageing. This feature, taken together with delayed childbearing in modern society, leads to the emergence of age-related ovarian dysfunction concomitantly with the desire for pregnancy. Assisted reproductive technology is frequently inefficacious in cases of ovarian ageing, thus raising the economic, medical and societal costs of the procedures...
August 25, 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/27535959/the-novel-pig-in-vitro-maturation-system-to-improve-developmental-competence-of-oocytes-derived-from-atretic-non-vascularized-follicle
#14
Asako Okamoto, Maki Ikeda, Aeri Kaneko, Chika Kishida, Masayuki Shimada, Yasuhisa Yamashita
The in vitro maturation (IVM) technique is beneficial for producing animal offspring, but the blastocyst rate is low after IVM. In this technique, cumulus-oocyte complexes (COCs) are collected from medium size follicles. The follicles are ultimately selected as large dominant follicles or atretic follicles; therefore it is possible that the COCs collected using IVM are contaminated by follicles that will develop into large follicles and induce atresia. In the dominant follicles, estradiol-17beta and progesterone induce the differentiation of follicular somatic cells which exhibit the ability to respond to ovulation during follicular development...
August 17, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27530864/di-2-ethylhexyl-phthalate-adverse-effects-on-folliculogenesis-that-cannot-be-neglected
#15
Teng Zhang, Wei Shen, Massimo De Felici, Xi-Feng Zhang
Primordial follicle formation and the subsequent transition of follicles through primary and secondary stages constitute crucial events of oogenesis. In particular, in mammals, defects in the processes that precede and accompany the formation of the primordial follicle pool can affect the size of this population significantly, while alterations in follicle activation, growth and maturation can result in premature depletion of the follicle reserve or cause follicle arrest at immature stages. Over the last decade, in vitro and in vivo approaches have been used to provide evidence that exposure to di(2-ethylhexyl)phthalate(DEHP), the most widely used plasticizer, has a deleterious effect on various stages of folliculogenesis in rodents...
October 2016: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/27495896/dehp-exposure-in-utero-disturbs-sex-determination-and-is-potentially-linked-with-precocious-puberty-in-female-mice
#16
Yongan Wang, Qing Yang, Wei Liu, Mingxi Yu, Zhou Zhang, Xiaoyu Cui
Human's ubiquitous exposure to di (2-ethylhexyl) phthalate (DEHP) is thought to be associated with female reproductive toxicity. Previous studies found that DEHP inhibited follicle growth and decreased estradiol levels in adult female mice. However, limited information is available on the link between in utero DEHP exposure and ovarian development in female mouse offspring. The present study evaluates the disturbances in regulatory genes involved in female sex determination and the ovarian outcomes in fetal and postnatal female mice treated with in utero DEHP exposure...
September 15, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27460518/genomic-portrait-of-ovarian-follicle-growth-regulation-in-cattle
#17
Anna E Zielak-Steciwko, Alexander C O Evans
The female reproductive cycle is characterized by cyclic patterns of growth of ovarian follicles destined to ovulate and the degeneration of those not chosen for ovulation. Apoptosis is the underlying mechanism of ovarian follicle degeneration during atresia. The fate of ovarian follicles is under the control of endocrine hormones (e.g. gonadotropins) and intra-ovarian regulators (e.g. growth factors and gonadal steroids), but the intra-cellular and molecular regulation of follicle fate (cellular proliferation or atresia) are still not fully understood...
September 2016: Reproductive Biology
https://www.readbyqxmd.com/read/27436181/age-associated-up-regulation-of-egr1-promotes-granulosa-cell-apoptosis-during-follicle-atresia-in-mice-through-the-nf-%C3%AE%C2%BAb-pathway
#18
Suzhen Yuan, Jingyi Wen, Jing Cheng, Wei Shen, Su Zhou, Wei Yan, Lu Shen, Aiyue Luo, Shixuan Wang
Follicular atresia is the main process responsible for the loss of follicles and oocytes from the ovary, and it is the root cause of ovarian aging. Apoptosis of granulosa cells (GCs) is the cellular mechanism responsible for follicular atresia in mammals. Recent advances have highlighted fundamental roles for EGR1 in age-related diseases via the induction of apoptosis. In the present study, we found that the expression of EGR1 was significantly increased in aged mouse ovaries compared with young ovaries. Immunohistochemical analysis revealed strongly positive EGR1 staining in atretic follicles, especially in apoptotic granulosa cells...
November 2016: Cell Cycle
https://www.readbyqxmd.com/read/27417237/microrna-let-7g-regulates-mouse-granulosa-cell-autophagy-by-targeting-insulin-like-growth-factor-1-receptor
#19
Jilong Zhou, Wang Yao, Kaiqing Liu, Qiannan Wen, Wangjun Wu, Honglin Liu, Qifa Li
As an important type of somatic cell, granulosa cells play a major role in deciding the fate of follicles. Therefore, analyses of granulosa cell apoptosis and follicular atresia have become hotspots of animal research. Autophagy is a cellular catabolic mechanism that protects cells from stress conditions, including starvation, hypoxia, and accumulation of misfolded proteins. However, the relationship between autophagy and apoptosis in granulosa cells is not well known. Here, we demonstrate that let-7g regulates the mouse granulosa cell autophagy signaling pathway by inhibiting insulin-like growth factor 1 receptor expression and affecting the phosphorylation of protein kinase B/mammalian target of rapamycin...
September 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27391761/effects-of-melatonin-on-follicular-atresia-and-granulosa-cell-apoptosis-in-the-porcine
#20
Yamei He, Honghui Deng, Zhongliang Jiang, Qingwang Li, Meihong Shi, Huali Chen, Zengsheng Han
The accumulation of reactive oxygen species is detrimental to the health of the ovarian follicle. The protective, antioxidant properties of melatonin, an endogenous component of porcine follicular fluid, on apoptosis of granulosa cells were evaluated in this study. Porcine granulosa cells from medium-sized (3-5 mm), healthy follicles were cultured in serum-free conditions with melatonin (0, 0.01, 0.1, 1.0, 10, and 100 ng/mL) with or without its receptor antagonist, luzindole, followed by evaluation of apoptotic markers in the treated cells...
August 2016: Molecular Reproduction and Development
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