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https://www.readbyqxmd.com/read/29777510/clopidogrel-pharmacogenetics-in-iranian-patients-undergoing-percutaneous-coronary-intervention
#1
Nejat Mahdieh, Ahmad Rabbani, Ata Firouzi, Ali Zahedmehr, Maryam Hoseinimoghaddam, Sedigheh Saeidi, Hamidreza Sanati, Hosseinali Basiri, Feridoun Noohi, Bahareh Rabbani, Majid Maleki
Clopidogrel is used in patients with coronary syndromes and at risk of thrombotic events or receiving percutaneous coronary intervention (PCI) for reducing heart attack and stroke. Here we present genotype and phenotype study of Iranian patients undergoing PCI treated with clopidogrel during a 6-month period of follow-up; common variants of CYP2C19, CYP3A5, CYP3A4, and ABCB1 genes were determined as well as the patients' cardiovascular outcomes to find out the effect of these variants individually and in combination...
May 18, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29768318/angiographic-characteristics-of-st-elevation-myocardial-infarction-patients-with-infarct-related-coronary-artery-ectasia-undergoing-primary-percutaneous-coronary-intervention
#2
Babak Geraiely, Mojtaba Salarifar, Mohammad Alidoosti, Seyedeh Hamideh Mortazavi
Coronary ectasia accounts for 0.3%-4.9% of patients undergoing coronary angiography. We conducted the present study to evaluate the angiographic characteristics of ST-elevation myocardial infarction (STEMI) patients with infarct-related coronary artery ectasia (IRAE) undergoing primary percutaneous coronary intervention. We evaluated 667 STEMI patients who were divided into 2 groups of IRAE (n = 81) and non-IRAE (n = 568). Preprocedural thrombolysis in myocardial infarction (TIMI) flow grade, postprocedural TIMI flow grade, thrombus burden grade, and TIMI frame count were then evaluated...
June 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29754760/the-role-of-scube1-in-the-development-of-late-stent-thrombosis-presenting-with-st-elevation-myocardial-infarction
#3
Hasan Ata Bolayır, Tarık Kıvrak, Hakan Güneş, Dursun Akaslan, Ömer Şahin, Aslı Bolayır
INTRODUCTION AND AIM: There is an important link between platelets and inflammation, thrombosis, and vascular and tissue repair mechanisms. SCUBE1 (signal peptide-CUB-EGF domain-containing protein 1) may function as a novel platelet-endothelial adhesion molecule and play pathological roles in cardiovascular biology. Stent thrombosis (ST) following percutaneous coronary intervention is an uncommon and potentially catastrophic event that can manifest as myocardial infarction and sudden death...
May 10, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29751953/temporal-trends-and-factors-associated-with-prolonged-length-of-stay-in-patients-with-st-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#4
Poonam Velagapudi, Dhaval Kolte, Kashif Ather, Sahil Khera, Tanush Gupta, Paul C Gordon, Herbert D Aronow, Ajay J Kirtane, J Dawn Abbott
Improved procedural techniques and process of care initiatives have decreased length of stay (LOS) after primary percutaneous coronary intervention (PPCI) for ST-elevation myocardial infarction (STEMI). However, there remains a subset of patients who continue to require longer LOS. We used the 2005 to 2014 National Inpatient Sample databases to identify all hospitalizations for PPCI for STEMI in patients ≥18 years of age. Hospitalizations in which patients were discharged home alive were included. Multivariable linear and logistic regression models were used to examine temporal trends in LOS and to identify independent predictors of longer LOS (LOS >3 days)...
April 11, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29726987/admission-macrophage-migration-inhibitory-factor-predicts-long-term-prognosis-in-patients-with-st-elevation-myocardial-infarction
#5
Xiang-Ning Deng, Xin-Yu Wang, Hai-Yi Yu, Shao-Min Chen, Xin-Ye Xu, Wei Huai, Gui-Hua Liu, Qing-Bian Ma, You-Yi Zhang, Anthony M Dart, Xiao-Jun Du, Wei Gao
Background: We previously showed in patients with ST-segment elevated myocardial infarction (STEMI) that admission levels of macrophage migration inhibitory factor (MIF) predict infarct size. It remains unclear whether admission MIF alone or in combination with other biomarkers is useful for risk assessment of acute and chronic clinical outcomes in STEMI patients. Methods and Results: 566 STEMI patients treated with primary percutaneous coronary intervention (PCI) were consecutively recruited...
May 2, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29725361/predictors-of-decreased-left-ventricular-function-subsequent-to-follow-up-echocardiography-after-percutaneous-coronary-intervention-following-acute-st-elevation-myocardial-infarction
#6
Dong-Hee Kim, Chang-Bum Park, Eun-Sun Jin, Hui-Jeong Hwang, Il Suk Sohn, Jin-Man Cho, Chong-Jin Kim
The preferred treatment for patients with ST elevation myocardial infarction (STEMI) is primary percutaneous coronary intervention (PCI). However, not all patients improve or maintain heart function following primary PCI, and certain patients may experience decreased heart function. The present study investigated factors associated with left ventricular (LV) dysfunction, and improvement or deterioration of LV ejection fraction (LVEF) at follow-up echocardiography following successful primary PCI. The clinical outcomes following primary PCI were also investigated...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29720999/the-contribution-of-gender-and-age-on-early-and-late-mortality-following-st-segment-elevation-myocardial-infarction-results-from-the-korean-acute-myocardial-infarction-national-registry-with-registries
#7
Ae-Young Her, Eun-Seok Shin, Yong Hoon Kim, Scot Garg, Myung Ho Jeong
Background: Although previous studies using Korean data have already reported higher rates of mortality in women, it is less clear whether these gender differences in prognosis post ST-segment elevation myocardial infarction (STEMI), are age dependent. The aim of this study is to examine the gender-age interaction with early and late mortality in patients with STEMI enrolled in the Korean nationwide registry. Methods: This prospective study stratified outcomes according to gender and age from 17,021 STEMI patients...
March 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29719035/single-center-retrospective-study-of-risk-factors-and-predictive-value-of-framingham-risk-score-of-patients-with-st-elevation-myocardial-infarction
#8
Sohail Ikram, Ajay Pachika, Henrike Schuster, Aman Ghotra, Laura Dotson, Shoaib Akbar, Abdur Rahman Khan
OBJECTIVES: The objective of this study was to identify risk factors and clinical profile of the patients presenting with ST elevation myocardial infarction (STEMI). We further evaluated the utility of the Framingham Risk Score (FRS) in the accurate identification of these patients if used before their coronary event. METHODS: We evaluated the demographic, clinical, and angiographic characteristics of patients admitted with STEMI. We also calculated cardiovascular event risk using the FRS in a subset of patients without prior known coronary artery disease and diabetes mellitus...
April 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29709405/influence-of-obesity-and-metabolic-syndrome-on-clinical-outcomes-of-st-segment-elevation-myocardial-infarction-in-men-undergoing-primary-percutaneous-coronary-intervention
#9
Seung Hun Lee, Myung Ho Jeong, Ju Han Kim, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Youngkeun Ahn, Shung Chull Chae, In Whan Seong, Jong Sun Park, Jei Keon Chae, Seung Ho Hur, Kwang-Soo Cha, Hyo-Soo Kim, Hyeon Cheol Gwon, Ki Bae Seung, Seung Woon Rha
BACKGROUND: The correlation between obesity and metabolic syndrome (MetS) and its impact on cardiovascular disease remains unclear. This study aims to investigate the impact of metabolic status and obesity on clinical outcomes of male patients with ST-segment elevation myocardial infarction (STEMI). METHODS: Data from the Korea Acute Myocardial Infarction Registry-National Institutes of Health registry were used to evaluate the impact of obesity and MetS on patients undergoing primary percutaneous coronary intervention (PPCI) from November 2005 to November 2015...
April 27, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29703083/relationship-between-circulating-mirna-30e-and-no-reflow-phenomenon-in-stemi-patients-undergoing-primary-coronary-intervention
#10
Qiang Su, Ziliang Ye, Yuhan Sun, Huafeng Yang, Lang Li
To investigate the relationship between miRNA-30e level in circulation and no-reflow phenomenon in patients with acute ST-segment elevation myocardial infarction (STEMI) during primary percutaneous coronary intervention (pPCI). A total of 255 consecutive patients with STEMI undergoing pPCI were enrolled in this study. These patients were divided into two groups according to the occurrence of reflow during pPCI, namely normal-reflow group with 214 cases and no-reflow group with 41 cases. The plasma levels of miRNA-30e were quantified using real-time quantitative polymerase chain reaction...
April 27, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29699746/characteristics-management-and-outcome-of-transient-st-elevation-versus-persistent-st-elevation-and-non-st-elevation-myocardial-infarction
#11
David S Blondheim, Michael Kleiner-Shochat, Aya Asif, Mark Kazatsker, Aaron Frimerman, Rami Abu-Fanne, Elena Neiman, Maguli Barel, Yaniv Levy, Naama Amsalem, Avraham Shotan, Simcha R Meisel
Patients with acute myocardial infarctions (AMIs) present as persistent ST-elevation myocardial infarction (STEMI) or as non-ST-segment elevation myocardial infarction (NSTEMI). In some patients with STEMI, ST elevations are transient and resolve before coronary intervention (transient ST-elevation myocardial infarction [TSTEMI]). We analyzed our registry comprising all consecutive patients with AMI admitted during 2009 to 2014, and compared the characteristics, management, and outcome of patients with TSTEMI with those of patients with STEMI and NSTEMI...
March 12, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29691186/does-micropuncture-technique-really-help-reduce-vascular-complications
#12
Hari Bogabathina, Sampath Singireddy, Runhua Shi, Liam Morris, Abdulrahman Abdulbaki, Henock Zabher, Pavan Katikaneni, Kalgi Modi
BACKGROUND: Micropuncture technique (MPT) is being adapted nationally to reduce vascular complications (VC). We initiated a quality improvement project in our cath lab to reduce VCs utilizing MPT. METHODS: We utilized MPT on all of our non-STEMI femoral artery (FA) access cases starting September 2016. As a comparator group, we collected data from April to August 2016. Anatomic localization of FA and fluoroscopic marking of femoral head was utilized in all cases...
March 26, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29685010/expressions-and-clinical-significance-of-factors-related-to-acute-coronary-syndrome
#13
H Sun, J Zhang, Y Zheng, S Shang
Acute coronary syndrome (ACS) is the acute stage of coronary artery disease, which remains a major cause of mortality and morbidity. It is essential to explore the role of matrix metalloproteinase -2 (MMP-2) and interleukin (IL)-18 and their association with disease in patients with severe ACS. Circulating MMP-2 and IL-18 levels were measured using enzyme linked immunosorbent assay (ELISA) in 94 subjects with acute coronary syndrome (ACS, n=38), stable angina pectoris (SAP, n=27) and healthy individuals (control group, n=29)...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29670472/seasonal-incidence-of-acute-coronary-syndrome-and-its-features
#14
Enisa Hodzic, Semir Perla, Amer Iglica, Marina Vucijak
Introduction: Acute coronary syndrome (ACS) is one of the most common health problems in the world and the leading cause of death. Goal: The goals of this study are to determine: ACS type, risk factors, incidence and the seasonal distribution of occurrence Spring/Summer, Autumn/Winter, ACS incidence by age and gender, and complications (post-infarction angina and heart failure) and fatal outcomes of ACS per season. Material and methodology: This study is designed as retrospective-prospective and analytical, which included 250 patients hospitalized in the Intensive Cardiac care unit of the Clinic for heart disease, blood vessels and rheumatism in the period from June 2013 to July 2014...
March 2018: Materia Socio-medica
https://www.readbyqxmd.com/read/29665154/development-and-validation-of-a-risk-stratification-score-for-new-onset-atrial-fibrillation-in-stemi-patients-undergoing-primary-percutaneous-coronary-intervention
#15
Annamaria Mazzone, Marco Scalese, Umberto Paradossi, Serena Del Turco, Nicoletta Botto, Alberto De Caterina, Giuseppe Trianni, Marcello Ravani, Antonio Rizza, Sabrina Molinaro, Cataldo Palmieri, Sergio Berti, Giuseppina Basta
AIM: New-onset atrial fibrillation (NOAF) is a complication not infrequent in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) and has been associated with worse in-hospital and long-term prognosis. We aimed to develop and validate a risk score based on common clinical risk factors and routine blood biomarkers to assess the early incidence of NOAF post-pPCI, before discharge. METHODS: The risk score for NOAF occurrence during hospitalisation (about 5 days) was developed in a cohort of 1135 consecutive STEMI patients undergoing pPCI while was externally validated in a temporal cohort of 771 STEMI patients...
April 17, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29657032/referral-for-cardiac-rehabilitation-after-acute-myocardial-infarction-insights-from-nationwide-amis-plus-registry-2005-2017
#16
Matthias Hermann, Fabienne Witassek, Paul Erne, Dragana Radovanovic, Hans Rickli
BACKGROUND: Referral rates for cardiac rehabilitation (CR) after an acute myocardial infarction (AMI) are low despite a Class I recommendation in the present guidelines. Therefore, we aimed to identify predictors for referral and patient characteristics from the national Swiss AMIS Plus registry. DESIGN AND METHODS: Data were extracted from the Swiss AMIS Plus registry between 2005 and 2017, which included patients with ST-elevation myocardial infarction (STEMI) and Non-ST-elevation myocardial infarction (NSTEMI)...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29642997/gender-differences-in-symptom-presentation-of-st-elevation-myocardial-infarction-an-observational-multicenter-survey-study
#17
Sofia Sederholm Lawesson, Rose-Marie Isaksson, Ingela Thylén, Maria Ericsson, Karin Ängerud, Eva Swahn
BACKGROUND: Symptom presentation has been sparsely studied from a gender perspective restricting the inclusion to ST elevation myocardial infarction (STEMI) patients. Correct symptom recognition is vital in order to promptly seek care in STEMI where fast reperfusion therapy is of utmost importance. Female gender has been found associated with atypical presentation in studies on mixed MI populations but it is unclear whether this is valid also in STEMI. OBJECTIVES: We assessed whether there are gender differences in symptoms and interpretation of these in STEMI, and if this is attributable to sociodemographic and clinical factors...
March 24, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29622964/correlation-of-corrected-qt-dispersion-with-the-severity-of-coronary-artery-disease-detected-by-syntax-score-in-non-diabetic-patients-with-stemi
#18
Hatem Helmy, Ahmed Abdel-Galeel, Yehia Taha Kishk, Khaled Mohammed Sleem
Introduction: Determination of the QT interval dispersion by means of a standard ECG at rest has been widely used for cardiovascular risk assessment during the last 15 years as one of the recent explanations for the development of life threatening ventricular arrhythmias. However, little is known about the relation between QT dispersion and the severity of coronary artery atherosclerosis as defined by SYNTAX score. Aim of work: The present study was done to assess the correlation between QTc dispersion and the severity of coronary artery disease in acute ST elevation myocardial infarction (STEMI) detected by SYNTAX score...
June 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29582106/trends-and-variations-in-the-prescribing-of-secondary-preventative-cardiovascular-therapies-for-non-st-elevation-myocardial-infarction-nstemi-in-malaysia
#19
Padmaa Venkatason, Nur Lisa Zaharan, Muhammad Dzafir Ismail, Wan Azman Wan Ahmad, Ahmad Syadi Mahmood Zuhdi
PURPOSE: Information is lacking on prescribing of preventative cardiovascular pharmacotherapies for patients with non-ST elevation myocardial infarction (NSTEMI) in the Asian region. This study examined the prescribing rate of these pharmacotherapies, comparing NSTEMI to STEMI, and variations across demographics and clinical factors within the NSTEMI group in the multi-ethnic Malaysian population. METHODS: This is a retrospective analysis of the Malaysian National Cardiovascular Disease Database-Acute Coronary Syndrome registry from year 2006 to 2013 (n = 30,873)...
March 26, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29578439/occupational-hazards-as-a-risk-factor-of-onset-and-unfavorable-outcome-of-ischemic-heart-disease
#20
H Svitlyk, M Harbar, V Salo, O Kapustynskyy, Y Svitlyk
Objective -to identify the role of occupational hazards (OH) as a risk factor of onset and unfavorable outcome of coronary artery disease (CAD). Retrospective study included analysis of 307 case reports of CAD patients, including 59 patients with long term history of OH exposure. Prospective study included observation of 244 STEMI patients during their in-patient treatment, including 113 patients with prior exposure to OH. OH were demonstrated to contribute to the risk of CAD, and to be directly involved in atherosclerotic coronary artery (CA) injury, its role being equal to that of the classical risk factors, such as arterial hypertension (AH), dyslipidemia, and diabetes mellitus (DM)...
February 2018: Georgian Medical News
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