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https://www.readbyqxmd.com/read/29453316/brd1-mediated-acetylation-promotes-integrin-%C3%AE-v-gene-expression-via-interaction-with-sulfatide
#1
Qian Qian Cai, Yi Wei Dong, Bing Qi, Xiao-Ting Shao, Rong Wang, Zhong Yi Chen, Bao Mei He, Xing Zhong Wu
Integrin αV (ITGAV) gene expression is often dysregulated in cancers especially in hepatocellular carcinoma (HCC); however, the mechanism of regulation is poorly understood. Here, it is demonstrated that sulfatide activated integrin αV gene transcription, through histone H3K9/14 acetylation at the promoter, and high integrin αV expression are closely associated with poor prognosis. To elucidate the mechanism of regulation of acetylation, sulfatide-bound proteins were screened by mass spectrometry (MS), and BRD1 (bromodomain containing protein 1) was identified as an interacting protein that also co-localized with sulfatide in HCC cells...
February 16, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29452105/label-free-electrochemical-aptasensor-for-detection-of-alpha-fetoprotein-based-on-afp-aptamer-and-thionin-reduced-graphene-oxide-gold-nanoparticles
#2
Guiyin Li, Shanshan Li, Zhihong Wang, Yewei Xue, Chenyang Dong, Junxiang Zeng, Yong Huang, Jintao Liang, Zhide Zhou
Sensitive and accurate detection of tumor markers is critical to early diagnosis, point-of-care and portable medical supervision. Alpha fetoprotein (AFP) is an important clinical tumor marker for hepatocellular carcinoma (HCC), and the concentration of AFP in human serum is related to the stage of HCC. In this paper, a label-free electrochemical aptasensor for AFP detection was fabricated using AFP-aptamer as the recognition molecule and thionin/reduced graphene oxide/gold nanoparticles (TH/RGO/Au NPs) as the sensor platform...
February 13, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29445190/the-chemokine-receptor-ccr10-promotes-inflammation-driven-hepatocarcinogenesis-via-pi3k-akt-pathway-activation
#3
Qiong Wu, Jin-Xian Chen, Yu Chen, Li-Li Cai, Xiao-Zhong Wang, Wu-Hua Guo, Jian-Feng Zheng
G-protein-coupled receptor (GPCR)-related proteins are dysregulated and the GPCR CC-chemokine receptor 10 (CCR10) is significantly upregulated in inflammation-driven HCC. However, CCR10's role in inflammation-driven hepatocarcinogenesis remains unknown. The aim of this study was to evaluate the role of CCR10 in inflammation-driven hepatocarcinogenesis. Via a targeted gene expression microarray screening alterations in GPCR family gene expression, we found CCR10 to be significantly upregulated in hepatocytes isolated from inflammation-driven human HCC tumors and matching paracancerous tissues...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29439451/wogonin-suppresses-the-activity-of-matrix-metalloproteinase-9-and-inhibits-migration-and-invasion-in-human-hepatocellular-carcinoma
#4
Ming Hong, Honghui Cheng, Lei Song, Wencai Wang, Qi Wang, Donggang Xu, Weiwei Xing
As one of the major active ingredients in Radix Scutellariae, wogonin has been shown to be associated with various pharmacological activities on cancer cell growth, apoptosis, and cell invasion and migration. Here, we demonstrated that wogonin may harbor potential anti-metastatic activities in hepatocarcinoma (HCC). The anti-metastasis potential of wogonin and its underlying mechanisms were evaluated by ligand-protein docking approach, surface plasmon resonance assay, and in vitro gelatin zymography studies...
February 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29438748/neuregulin-1-discovered-as-a-cleavage-target-for-the-hcv-ns3-4a-protease-by-a-microfluidic-membrane-protein-array
#5
Nika Schwartz, Michal Pellach, Yair Glick, Reuven Gil, Gahl Levy, Dorit Avrahami, Efrat Barbiro-Michaely, Yaakov Nahmias, Doron Gerber
The hepatitis C virus (HCV) non-structural protein 3 (NS3) is essential for HCV maturation. The NS3/4A protease is a target for several HCV treatments and is a well-known target for HCV drug discovery. The protein is membrane associated and thus probably interacts with other membrane proteins. However, the vast majority of known NS3 host partners are soluble proteins rather than membrane proteins, most likely due to lack of appropriate platforms for their discovery. Utilization of an integrated microfluidics platform enables analysis of membrane proteins in their native form...
February 10, 2018: New Biotechnology
https://www.readbyqxmd.com/read/29436633/microarray-analysis-for-the-identification-of-specific-proteins-and-functional-modules-involved-in-the-process-of-hepatocellular-carcinoma-originating-from-cirrhotic-liver
#6
Wufeng Fan, Guangming Ye
In order to identify the potential pathogenesis of hepatocellular carcinoma (HCC) developing from cirrhosis, a microarray‑based transcriptome profile was analyzed. The GSE63898 expression profile was downloaded from the Gene Expression Omnibus database, which included data from 228 HCC tissue samples and 168 cirrhotic tissue samples. The Robust Multi‑array Average in the Affy package of R was used for raw data processing and Student's t‑test was used to screen differentially expressed genes (DEGs). An enrichment analysis was then conducted using the Database for Annotation, Visualization and Integrated Discovery online tool, and the protein‑protein interaction (PPI) network was constructed using the Search Tool for the Retrieval of Interacting Genes and Cytoscape...
February 2, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29435219/medullary-like-hepatocellular-carcinoma
#7
Alessandra Cristaudi, Jessica Barizzi, Raffaele Rosso, Marco Varini, Mario Alerci, Laura Rubbia Brandt, Pietro Majno, Ruben Carlo Balzarotti Canger
Hepatocellular carcinoma (HCC) is the most frequent primary hepatic cancer. Pathological features can define the biological behavior and prognosis. Medullary-like HCC is a very rare variant that has been described only twice in literature. In the present study, we report the case of a non-cirrhotic 72-year-old man, who presented two HCC lesions on routine screening for hepatitis C virus liver disease. Radiological imaging and biopsy showed two different subtypes: one classic HCC, which was treated with chemoembolization, and a second PET/CT-positive carcinoma with a PET/CT-positive metastatic coeliac lymph node, which was resected laparoscopically with a left lateral sectionectomy and extended lymphadenectomy...
February 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29434874/antitumor-effects-of-matrine-on-cancer-stem-like-cells-isolated-from-the-human-liver-cancer-smmc-7721-cell-line
#8
Yong Wang, Yahui Liu, Jianshuai Jiang, Hanbin Cui
The existence of cancer stem cells (CSCs) or cancer stem-like cells (CSLCs) is regarded as the cause of tumor formation and recurrence. Matrine has been reported to exhibit antitumor effects in cancer cells. In the present study, a preliminary study was performed on the mechanisms of matrine on hepatocellular carcinoma (HCC) stem-like cells. The HCC SMMC-7721 cell line was cultured in tumor stem cell-specific medium to form spheres, and different concentrations (1, 2 and 5 mg/kg) of cisplatin were then used in order to purify the most drug-resistant cells, which were used as CSLCs...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29432829/vitamin-d-receptor-gene-methylation-in-hepatocellular-carcinoma
#9
Mai Abdalla, Eman Khairy, Manal L Louka, Randa Ali-Labib, Eman Abdel-Salam Ibrahim
Worldwide, hepatocellular carcinoma (HCC) is the major subtype of primary liver cancers. HCC is typically diagnosed late in its course. With respect to cancer, the genomic actions of vitamin D are mediated through binding to the Vitamin D Receptor (VDR), which allows it to modulate the expression of genes in a cell-and tissue-specific manner. Epigenetics is a rapidly evolving field of genetic study applicable to HCC. Changes in DNA methylation patterns are thought to be early events in hepatocarcinogenesis...
February 9, 2018: Gene
https://www.readbyqxmd.com/read/29427493/the-next-wave-of-hepatitis-c-virus-the-epidemic-of-intravenous-drug-use
#10
REVIEW
Mitchell L Shiffman
The epidemic of hepatitis C virus (HCV) began in the 1960s when transmission was primarily the result of blood transfusions. By 1990, when HCV was identified and a serologic test for screening donated blood was implemented, 123 million persons had already become infected worldwide and HCV was the most common cause of cirrhosis, hepatocellular carcinoma and the most common indication for liver transplantation. Approximately 75% of persons with HCV are "baby boomers" born between the years 1945 and 1965...
February 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29427486/management-of-patients-with-non-alcoholic-steatohepatitis-nash-in-real-life
#11
REVIEW
Lawrence Serfaty
Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) is a prevalent condition that is associated with the development of cirrhosis and hepatocellular carcinoma and with no approved treatment options except for lifestyle changes. Guidelines have been drafted for the management of NAFLD patients in this setting. Because of the lack of real-life cohort data, we will focus on practice surveys on the management of patients with NAFLD/NASH, which included primary care practitioners, gastroenterologists/hepatologists and other specialists from various countries...
February 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29427482/how-to-improve-access-to-therapy-in-hepatitis-b-patients
#12
REVIEW
Miroslava Subic, Fabien Zoulim
Despite the availability of a preventive vaccine and active antiviral treatments that stop disease progression and reduce the risk of hepatocellular carcinoma, hepatitis B is still a major public health problem. Only an estimated 10% of the 257 million people living with HBV have been diagnosed and as few as 1% are being adequately treated. Barriers to diagnosis and treatment include: (i) limited awareness and lack of knowledge about HBV infection and HBV-related diseases; (ii) under-diagnosis with insufficient screening and referral to care; (iii) limited treatment due to drug availability, costs, reimbursement policies and the need for long-term or life-long therapy...
February 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29425151/liver-transplantation-for-alcoholic-liver-disease-and-hepatocellular-carcinoma
#13
REVIEW
Patrizia Burra, Alberto Zanetto, Giacomo Germani
Hepatocellular carcinoma is one of the main important causes of cancer-related death and its mortality is increasingly worldwide. In Europe, alcohol abuse accounts for approximately half of all liver cancer cases and it will become the leading cause of hepatocellular carcinoma in the next future with the sharp decline of chronic viral hepatitis. The pathophysiology of alcohol-induced carcinogenesis involves acetaldehyde catabolism, oxidative stress and chronic liver inflammation. Genetic background plays also a significant role and specific patterns of gene mutations in alcohol-related hepatocellular carcinoma have been characterized...
February 9, 2018: Cancers
https://www.readbyqxmd.com/read/29424599/screening-of-biomarkers-for-liver-adenoma-in-low-dose-rate-gamma-ray-irradiated-mice
#14
Takashi Sugihara, Satoshi Tanaka, Ignacia Braga-Tanaka, Hayato Murano, Masako Nakamura-Murano, Jun-Ichiro Komura
PURPOSE: Chronic low-dose-rate (20 mGy/d) gamma-irradiation increases the incidence of hepatocellular adenomas (HCA) in female B6C3F1 mice. The purpose of this study is to identify potential serum biomarkers for these HCAs by a new approach. MATERIAL AND METHODS: Microarray analysis were performed to compare the gene expression profiles of HCAs from mice exposed to low-dose-rate gamma rays with those of normal livers from non-irradiated mice. From the differentially expressed genes, those for possibly secretory proteins were selected...
February 9, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29416626/utilizing-glycine-n-methyltransferasegene-knockout-mice-as-a-model-for-identification-of-missing-proteins-in-hepatocellular-carcinoma
#15
Ming-Hui Yang, Wan-Jou Chen, Yaw-Syan Fu, Bin Huang, Wan-Chi Tsai, Yi-Ming Arthur Chen, Po-Chiao Lin, Cheng-Hui Yuan, Yu-Chang Tyan
Glycine N-methyltransferase is a tumor suppressor gene for hepatocellular carcinoma, which can activate DNA methylation by inducing the S-adenosylmethionine to S-adenosylhomocystine. Previous studies have indicated that the expression of Glycine N-methyltransferase is inhibited in hepatocellular carcinoma. To confirm and identify missing proteins, the pathologic analysis of the tumor-bearing mice will provide critical histologic information. Such a mouse model is applied as a screening tool for hepatocellular carcinoma as well as a strategy for missing protein discovery...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29408492/transcriptomic-analyses-of-chemokines-reveal-that-down-regulation-of-xcr1-is-associated-with-advanced-hepatocellular-carcinoma
#16
Wang Yanru, Bai Zhenyu, Niu Zhengchuan, Qi Qi, Liang Chunmin, Yao Weiqiang
Chemokines are essential coordinators of cellular migration and cell-cell interactions, therefore considerable attention has been paid to the application of chemokines to cancer immunotherapy. In this study, we screened for the expression levels of 58 human chemokines/chemokine receptors in hepatocellular carcinoma (HCC) by using samples from the TCGA LIHC cohort and found 16 consistently down-regulated and 11 up-regulated chemokine genes in HCC compared with normal samples. Furthermore, the expressions of XCR1 were verified by Western blot in liver cancer cell lines...
February 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29407981/the-lead-optimization-of-the-polyamine-conjugate-of-flavonoid-with-a-naphthalene-motif-synthesis-and-biological-evaluation
#17
Qian Li, Zi-Xin Zhu, Xin Zhang, Wen Luo, Li-Ping Chang, Shuai Chen, Yu-Xia Wang, Song-Qiang Xie, Cong-Cong Chang, Chao-Jie Wang
Polyamine conjugated flavonoid with a naphthalene moiety (ZYY14) displayed excellent therapeutic activity against hepatocellular carcinoma. In this study, three different series of novel flavonoid-polyamine conjugates were designed and screened against tumor cell lines. The structure-activity relationship study demonstrated the importance of the naphthalene moiety (as the B-ring), the basic side chains in the A-ring, and the methoxy group linked to the C-ring. The optimized compound 9b displayed better antitumor potency in vitro and in vivo than the lead compound ZYY14...
January 31, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29399157/the-serum-metabolic-profiles-of-different-barcelona-stages-hepatocellular-carcinoma-associated-with-hepatitis-b-virus
#18
Lei Zhang, Guang-Ye Wu, Yu-Jing Wu, Shu-Ye Liu
The present study aimed to explore the characteristic ions distinguishing different Barcelona stages in patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) using the ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) platform, and to evaluate their value in diagnosing and monitoring the progress of HCC. The serum was sampled from 20 healthy volunteers, 20 patients with HBV-induced cirrhosis and 75 patients with HBV-associated HCC of different BCLC stages. Samples were all examined using UPLC-MS...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29399153/silymarin-mediated-regulation-of-the-cell-cycle-and-dna-damage-response-exerts-antitumor-activity-in-human-hepatocellular-carcinoma
#19
Hong Cui, Tie-Ling Li, Hai-Feng Guo, Jia-Liang Wang, Ping Xue, Ying Zhang, Jing-Hui Fan, Zhi-Ping Li, Yue-Juan Gao
A novel module-search algorithm method was used to screen for potential signatures and investigate the molecular mechanisms of inhibiting hepatocellular carcinoma (HCC) growth following treatment with silymarin (SM). The modules algorithm was used to identify the modules via three major steps: i) Seed gene selection; ii) module search by seed expansion and entropy minimization; and iii) module refinement. The statistical significance of modules was computed to select the differential modules (DMs), followed by the identification of core modules using the attract method...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29391313/post-transplant-malignancies-in-pediatric-liver-transplant-recipients-experience-of-two-centers-in-turkey
#20
Miray Karakoyun, Şebnem Önen, Maşallah Baran, Murat Çakır, Çiğdem Ömür Ecevit, Murat Kılıç, Mehmet Kantar, Serap Aksoylar, Funda Özgenç, Sema Aydoğdu
BACKGROUND/AIMS: A liver transplant is the preferred treatment for patients with end-stage liver disease, as it usually results in longterm survival. However, due to the use of chronic immunosuppressive therapy, which is necessary to prevent rejection, de novo cancer is a major risk after transplantation. The aim of this study was to assess the incidence of post-transplant malignancies in children after liver transplantations. MATERIALS AND METHODS: The study group consisted of 206 liver transplant recipients, with no history of cancer, including hepatocellular carcinoma, in two liver transplantation centers in Turkey between 1997 and 2015...
January 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
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