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https://www.readbyqxmd.com/read/29232254/orthotropic-live-transplantation-for-cirrhosis-from-hepatitis-c-virus-leads-to-correction-of-factor-ix-deficiency-allowing-for-ankle-arthroplasty-without-factor-replacement-in-a-patient-with-moderate-haemophilia-b
#1
Kumiko Ono, Jun Hirose, Song H Chang, Minoru Kubota, Junya Kinkawa, Megumi Noguchi, Hideyuki Takedani
: Liver transplantation is one of the treatments for haemophilic patients having severe liver cirrhosis who are infected with the hepatitis C virus. Patients with haemophilia can develop arthroplasty requiring surgical intervention, and the surgical outcomes of patients undergoing such procedures after liver transplant has not been reported. Treatment for arthropathy is important for improving the quality of life for patients who survive after liver transplantation. We report the first case of ankle arthroscopic arthrodesis in a patient with haemophilia B after undergoing living donor liver transplantation...
December 11, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29231235/the-perioperative-use-of-synthetic-and-biological-disease-modifying-antirheumatic-drugs-in-patients-with-rheumatoid-arthritis
#2
Gregory Fleury, Silvano Mania, Didier Hannouche, Cem Gabay
Disease-modifying antirheumatic drugs (DMARDs) have become essential treatments in the management of patients with inflammatory rheumatic diseases. Their use has resulted in a marked improvement of disease control and a limitation of joint damage, although some patients still require subsequent corrective or joint replacement surgery. Due to their immunosuppressive effects, some DMARDs are associated with an increased risk of infection. The aim of this review is to discuss the available literature on the management of DMARDs during the perioperative period, particularly in the case of orthopaedic surgery...
December 12, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29230489/-potential-of-allogeneic-bone-grafts-as-antibiotic-carriers-effect-of-different-preparation-processes-on-efficacy
#3
REVIEW
D C Coraça-Huber, M Nogler, K-D Kühn
BACKGROUND: The rising number of primary joint replacements worldwide is causing an increase of endoprosthetic revision surgery due bacterial infection. Revision surgery using non-cemented implants seems beneficial for the long-term outcome, and the use of antibiotic-impregnated bone grafts might control the infection and provide a good support for the implant. In this study, we evaluated the release of antibiotics from fresh-frozen and lyophilized allogeneic bone grafts. METHODS: Heat-treated, lyophilized and fresh frozen cryopreserved bone chips were impregnated with gentamicin sulphate, gentamicin palmitate and vancomycin, and calcium carbonate/calcium sulphate treated with antibiotics...
December 11, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/29228407/-sport-after-total-knee-and-hip-arthroplasty
#4
Friedrich Boettner, Maximilian F Kasparek, Kilian Rueckl, Christian Liebau
The introduction of new materials and better implant coatings seems to provide the prerequisites for more intense physical activities after total joint arthroplasties of the lower extremity. Despite recent advances in implant design and materials, recommendations for sport after total joint arthroplasty have not been updated over the past 20 years. The introduction of modern uncemented fixation as well as highly cross-linked polyethylene into total hip arthroplasty allow for a more active life-style without an increased risk of loosening or complications...
December 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/29226660/bone-and-joint-diseases-in-present-and-future
#5
Yasuharu Nakashima, Ken Okazak, Koichiet Nakayama, Seiji Okada, Hideki Mizu-uchi
With the increase of elderly population, orthopaedic surgeons need to deal with the diseases related to aging, such as joint disorders and fragility fractures. The number of total joint replacements, for example, is two times more than it was 10 years ago. With these backgrounds, the Japanese Orthopaedic Association (JOA) has proposed the concept of locomotive syndrome; conditions under which the elderly have been receiving care services due to problems of the locomotive organs. To prevent geriatric or disuse syndrome, JOA is currently providing the care‒prevention programs such as the loco-check and loco-training...
January 2017: Fukuoka Igaku Zasshi, Hukuoka Acta Medica
https://www.readbyqxmd.com/read/29223595/modulation-of-cartilage-s-response-to-injury-can-chondrocyte-apoptosis-be-reversed
#6
REVIEW
Ippokratis Pountos, Peter V Giannoudis
Osteoarthritis is characterized by a chronic, progressive and irreversible degradation of the articular cartilage associated with joint inflammation and a reparative bone response. More than 100 million people are affected by this condition worldwide with significant health and welfare costs. Our available treatment options in osteoarthritis are extremely limited. Chondral or osteochondral grafts have shown some promising results but joint replacement surgery is by far the most common therapeutic approach. The difficulty lies on the limited regeneration capacity of the articular cartilage, poor blood supply and the paucity of resident progenitor stem cells...
December 2017: Injury
https://www.readbyqxmd.com/read/29216915/rheumatoid-arthritis-bone-marrow-environment-supports-th17-response
#7
Ewa Kuca-Warnawin, Weronika Kurowska, Monika Prochorec-Sobieszek, Anna Radzikowska, Tomasz Burakowski, Urszula Skalska, Magdalena Massalska, Magdalena Plebańczyk, Barbara Małdyk-Nowakowska, Iwona Słowińska, Robert Gasik, Włodzimierz Maśliński
BACKGROUND: Rheumatoid arthritis (RA) is a systemic, autoimmune disease leading to joint destruction and ultimately disability. Bone marrow (BM) is an important compartment in RA, where pathological processes from "outside the joint" can occur. IL-17 is a cytokine that exerts proinflammatory effects and participates in the process of bone destruction. It is believed that IL-17 is involved in pathogenesis of RA. However, little is known about the biology of this cytokine in BM. In the present study we investigated Th17-related cytokines in RA BM...
December 8, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29212694/minimising-aseptic-loosening-in-extreme-bone-resections-custom-made-tumour-endoprostheses-with-short-medullary-stems-and-extra-cortical-plates
#8
J D Stevenson, C Wigley, H Burton, S Ghezelayagh, G Morris, S Evans, M Parry, L Jeys
AIMS: Following the resection of an extensive amount of bone in the treatment of a tumour, the residual segment may be insufficient to accept a standard length intramedullary cemented stem. Short-stemmed endoprostheses conceivably have an increased risk of aseptic loosening. Extra-cortical plates have been added to minimise this risk by supplementing fixation. The aim of this study was to investigate the survivorship of short-stemmed endoprostheses and extra-cortical plates. PATIENTS AND METHODS: The study involved 37 patients who underwent limb salvage surgery for a primary neoplasm of bone between 1998 and 2013...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29212384/articular-and-subcutaneous-adipose-tissues-of-rheumatoid-arthritis-patients-represent-equal-sources-of-immunoregulatory-mesenchymal-stem-cells
#9
Urszula Skalska, Ewa Kuca-Warnawin, Anna Kornatka, Iwona Janicka, Urszula Musiałowicz, Tomasz Burakowski, Ewa Kontny
Adipose-derived mesenchymal stem cells (ASCs) have immunoregulatory properties, but their activity is dependent on signals provided by the local microenvironment. It is likely that highly inflammatory milieu of rheumatoid joint affects ASCs activity. To test this hypothesis, the function of rheumatoid ASCs derived from articular adipose tissue (AT-ASCs) and ASCs derived from subcutaneous adipose tissue (Sc-ASCs) has been analysed. Articular adipose tissue (infrapatellar fat pad) and subcutaneous adipose tissue (from the site of skin closure with sutures) were obtained from rheumatoid arthritis (RA) patients undergoing total knee joint replacement surgery...
December 6, 2017: Autoimmunity
https://www.readbyqxmd.com/read/29208013/patients-and-surgeons-provide-endorsement-of-core-domains-for-total-joint-replacement-clinical-trials
#10
Anh Hoang, Susan M Goodman, Iris Y Navarro-Millán, Lisa A Mandl, Mark P Figgie, Mathias P Bostrom, Douglas E Padgett, Peter K Sculco, Alexander S McLawhorn, Jasvinder A Singh
BACKGROUND: Our objective in this study was to examine whether stakeholders further endorse the core domain set proposed by the Outcome Measures in Rheumatology Trials (OMERACT) total joint replacement (TJR) working group. METHODS: We emailed a survey to 3810 hip/knee arthroplasty patients and 49 arthroplasty surgeons at a high-volume arthroplasty center to rate the importance of each core domain (i.e., pain, function, patient satisfaction, revision surgery, adverse events, and death) and two additional domains (i...
December 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29205992/curative-effect-of-knee-arthroplasty-on-patients-with-osteoarthritis-and-analysis-of-long-term-joint-function-of-these-patients
#11
Xianxun Wang, Lin Cai
BACKGROUND: We aimed to explore the curative effect of knee arthroplasty on patients with osteoarthritis and analysis of their long-term joint function. METHODS: 96 cases of osteoarthritis patients, collected in our hospital from June 2010 to May 2011, were divided into control group and observation group (n=48, each group). Patients in observation group were treated by knee replacement, and patients in control group were treated by arthroscopic debridement. Bleeding during operation of patients and the operation time in both groups were comparable during their followed up for 6~60 months, with an average of 52 months...
December 4, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29204492/joint-replacement-surgery-in-homeless-veterans
#12
Chase G Bennett, Laura Y Lu, Kathleen A Thomas, Nicholas J Giori
Total joint arthroplasty (TJA) in a homeless patient is generally considered contraindicated. Here, we report our known medical and social (housing and employment) results of homeless veterans who had TJA. Thirty-seven TJAs were performed on 33 homeless patients (31 men) at our hospital between November 2000 and March 2014. This was 1.2% of all TJAs. Average age was 54 years. Average hospital stay was 4.1 days. There were no major inpatient complications. Thirty-four cases had at least 1-year follow-up in any clinic within the Veterans Affairs health care system...
December 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/29198883/disease-burden-of-knee-osteoarthritis-patients-with-a-joint-replacement-compared-to-matched-controls-a-population-based-analysis-of-a-dutch-medical-claims-database
#13
Johannes T H Nielen, Annelies Boonen, Pieter C Dagnelie, Bart J F van den Bemt, Pieter J Emans, Floris P J G Lafeber, Willem E van Spil, Frank de Vries, Paco M J Welsing
OBJECTIVE: On a population level, the incidence of knee prostheses (KP) has increased, but excess health care costs per patient, compared to matched controls without a KP, in the years surrounding these procedures and their determinants are largely unknown. We therefore aimed to provide estimates of age and sex-specific incidence of KPs, revision KPs, and prosthesis complications in patients with knee osteoarthritis (OA) and to determine excess health care costs in the years surrounding surgery compared with matched controls...
November 30, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29196384/trends-in-joint-replacement-surgery-in-patients-with-rheumatoid-arthritis
#14
Bradley L Young, Shawna L Watson, Jorge L Perez, Gerald McGwin, Jasvinder A Singh, Brent A Ponce
OBJECTIVE: This study analyzed trends in large total joint arthroplasties (TJA) and in the proportion of these procedures performed on patients with rheumatoid arthritis (RA). METHODS: The US Nationwide Inpatient Sample (2002-2012) was used to identify the incidences of total shoulder (TSA), elbow (TEA), knee (TKA), hip (THA), and ankle (TAA) arthroplasty and the proportion of these performed with coexisting RA. RESULTS: The prevalence of RA among patients with TJA increased 3...
December 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29195854/hypothermia-in-total-joint-arthroplasty-a-wake-up-call
#15
Jordan B Simpson, Vijai S Thomas, Sabir K Ismaily, Pavel I Muradov, Philip C Noble, Stephen J Incavo
BACKGROUND: Total joint patients are particularly vulnerable to perioperative hypothermia (PH) (combined effects of anesthesia, radiation, and convective heat loss from exposed skin surfaces and cool temperatures in the operating room). There are limited studies on PH in these patients. METHODS: In a retrospective review of 204 patients undergoing primary hip and 179 undergoing primary knee replacement surgeries, time and temperature parameters were collected from the electronic health records from preoperative and postoperative recovery room nursing assessments, intraoperative anesthesia records, and floor nursing notes...
November 8, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29192730/3-phase-technicium-99m-bone-scanning-in-patients-with-pain-in-the-hip-region-after-cemented-total-hip-replacement-a-multicentre-series-of-100-cases
#16
Daniel S Hill, Soulat Naim, Roy J Powell, Denis Kinsella, Andrew D Toms, Jonathan Howell
INTRODUCTION: The aim of this study was to assess the benefit of a Technetium-99M (HDP) 3-phase bone scan (TPBS) as an additional diagnostic test in the evaluation of pain in the hip region following cemented total hip replacement (THR) surgery. METHODS: A retrospective study over a 24-month period was performed comprising 100 patients investigated with a TPBS. Investigations were summarised and analysed, and were classified as entirely normal, possibly abnormal, and definitely abnormal...
November 21, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29189881/satisfactory-functional-and-radiological-outcomes-can-be-expected-in-young-patients-under-45%C3%A2-years-old-after-open-wedge-high-tibial-osteotomy-in-a-long-term-follow-up
#17
Michael E Hantes, Prodromos Natsaridis, Antonios A Koutalos, Yohei Ono, Nikolaos Doxariotis, Konstantinos N Malizos
PURPOSE: To report the long-term outcomes of medial open wedge high tibial osteotomy (MOWHTO) for the treatment of medial compartment knee osteoarthritis in patients younger than 45 years old. It was hypothesized that the correction of knee alignment would result in preservation of knee function in a long-term follow-up. METHODS: Patients under 45 years old, who underwent MOWHTO for symptomatic medial compartment knee osteoarthritis between 2001 and 2005 were retrospectively reviewed after a minimum of 10 years...
November 30, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29189624/preoperative-risk-factors-for-subsyndromal-delirium-in-older-adults-who-undergo-joint-replacement-surgery
#18
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/29189623/preoperative-risk-factors-for-subsyndromal-delirium-in-older-adults-who-undergo-joint-replacement-surgery
#19
Dawn L Denny, Glenda Lindseth
BACKGROUND: Older adults with subsyndromal delirium have similar risks for adverse outcomes following joint replacement surgery as those who suffer from delirium. PURPOSE: This study examined relationships among subsyndromal delirium and select preoperative risk factors in older adults following major orthopaedic surgery. METHODS: Delirium assessments of a sample of 62 adults 65 years of age or older were completed on postoperative Days 1, 2, and 3 following joint replacement surgery...
November 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/29189125/use-of-antibiotic-loaded-biomaterials-for-the-management-of-bone-prosthesis-infections-rationale-and-limits
#20
Matilde Tschon, Maria Sartori, Deyanira Contartese, Gianluca Giavaresi, Nicolo Nicoli Aldini, Milena Fini
BACKGROUND: Periprosthetic joint infection still represents a challenging issue for the orthopedic community. In the United States approximately a million joint arthroplasties are performed each year, with infection rates ranging from 1 to 2%: revisions has significant implications in health care costs and appropriate resources management. The use of locally applied antibiotics as a prophylaxis measure or as a component of the therapeutic approach in primary or revision surgery is finalized at eliminating any microorganism and strengthening the effectiveness of systemic therapy...
November 29, 2017: Current Medicinal Chemistry
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