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https://www.readbyqxmd.com/read/28231671/-spatiotemporal-characteristics-of-hiv-aids-in-shandong-province-2009-2015
#1
N Zhang, X G Yang, G Y Wang, X R Tao, D M Kang, N Wang
Objective: To analyze the spatiotemporal characteristics of HIV/AIDS in Shandong province, 2009-2015. Methods: Data on HIV/AIDS between 2009 and 2015 were derived from the Shandong provincial HIV/AIDS Comprehensive Response Information Management System at the end of 2015. All the data were geographically referenced based on 139 spatial units in the related counties of Shandong province. Electronic maps were obtained from China CDC. Global Moran' s I statistics and LISA statistics were used to detect the global and local spatial distribution patterns of HIV/AIDS in Shandong...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28231592/cxcr4-a-new-player-in-an-old-scene
#2
Andreas Knopf, Marie Kristin Fritsche, Yin Li
Transmembrane C-X-C chemokine receptor 4 (CXCR4) and its ligand C-X-C motif chemokine 12 (CXCL12) came into focus in many solid cancers, allowing a more fundamental diagnostic and therapeutic approach by modulating the immune response against cancer cells. CXCR4 and CXCL12 mediate cell proliferation, migration, and metastatic outgrowth in head and neck squamous cell carcinoma (HNSCC) and are strongly associated with cancer recurrence and patient survival. Despite recent advances in molecular imaging and cancer therapy in lymphoma using CXCL12 analogues, clinical trials evaluating the diagnostic and therapeutic impact on HNSCC are missing...
February 24, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28229194/screening-level-assessment-of-metal-concentrations-in-streambed-sediments-and-floodplain-soils-within-the-grand-lake-watershed-in-northeastern-oklahoma-usa
#3
Ean M Garvin, Cas F Bridge, Meredith S Garvin
Metal releases have been received by the Grand Lake watershed from the Tri-State Mining District (TSMD) since the mid 1800s. To address data gaps in metal distributions in the Oklahoma portion of the watershed, streambed sediment and floodplain soil was sampled on various streams. The <63-µm fraction was analyzed for Cd, Pb, and Zn concentrations by portable X-ray fluorescence spectroscopy and inductively coupled plasma-mass spectrometry. Mean metal concentration results at reference transects indicated that background sediment/soil concentrations for Cd, Pb, and Zn within the watershed were 0...
February 22, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28229115/data-on-the-auditory-duration-mismatch-negativity-for-different-sound-pressure-levels-and-visual-perceptual-loads
#4
Stefan Wiens, Malina Szychowska, Rasmus Eklund, Mats E Nilsson
The data presented in this article are related to our research article entitled "Effects of sound pressure level and visual perceptual load on the auditory mismatch negativity" (M. Szychowska, R. Eklund, M.E. Nilsson, S. Wiens, 2016) [1]. The duration MMN was recorded at three sound pressure levels (SPLs) during two levels of visual perceptual load. In an oddball paradigm (standard=75 ms, deviant=30 ms, within-subjects design), participants were presented with tones at 56, 66, or 76 dB SPL (between-subjects design)...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28229112/chronic-psychosocial-stressors-in-adulthood-studies-in-mice-rats-and-tree-shrews
#5
REVIEW
Christopher R Pryce, Eberhard Fuchs
Human psychological stress is the major environmental risk factor for major depression and certain of the anxiety disorders. Psychological stressors often occur in the context of the adult social environment, and they or the memory formed of them impact on the individual across an extended period, thereby constituting chronic psychosocial stress (CPS). Psychosocial stressors often involve loss to the individual, such as the ending of a social relationship or the onset of interpersonal conflict leading to loss of social control and predictability...
February 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28228082/recent-advances-in-protein-tyrosine-phosphatase-1b-targeted-drug-discovery-for-type-ii-diabetes-and-obesity
#6
Neelesh Maheswari, Chandrabose Karthikeyan, Piyush Trivedi, N S Hari Narayana Moorthy
Protein tyrosine phosphatase 1B (PTP1B) is an important therapeutic target for type II diabetes and obesity because of its pivotal role as a negative modulator in both insulin and leptin signalling pathways. Consequently, the discovery of PTP1B inhibitors has been the focus of researchers in both academia and pharmaceutical industry over the last two decades. Though, intense pharmaceutical research in this area has resulted in many potent PTP1B inhibitors, a vast majority of them possessed pTyr mimetic group such as phosphonates, carboxylic acids and sulphamic acids, which led to poor PTP1B selectivity and insufficient in vivo efficacy due to low cell permeability and bioavailability...
February 22, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28228008/integration-of-highly-strained-sige-in-source-and-drain-with-hk-and-mg-for-22%C3%A2-nm-bulk-pmos-transistors
#7
Guilei Wang, Jun Luo, Changliang Qin, Renrong Liang, Yefeng Xu, Jinbiao Liu, Junfeng Li, Huaxiang Yin, Jiang Yan, Huilong Zhu, Jun Xu, Chao Zhao, Henry H Radamson, Tianchun Ye
In this study, the integration of SiGe selective epitaxy on source/drain regions and high-k and metal gate for 22 nm node bulk pMOS transistors has been presented. Selective Si1-x Ge x growth (0.35 ≤ × ≤ 0.40) with boron concentration of 1-3 × 10(20) cm(-3) was used to elevate the source/drain. The main focus was optimization of the growth parameters to improve the epitaxial quality where the high-resolution x-ray diffraction (HRXRD) and energy dispersive spectrometer (EDS) measurement data provided the key information about Ge profile in the transistor structure...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28228001/fabrication-of-progesterone-loaded-nanofibers-for-the-drug-delivery-applications-in-bovine
#8
Chitra Karuppannan, Mehnath Sivaraj, J Ganesh Kumar, Rangasamy Seerangan, S Balasubramanian, Dhinakar Raj Gopal
Progesterone is a potent drug for synchronization of the estrus and ovulation cycles in bovine. At present, the estrus cycle of bovine is controlled by the insertion of progesterone-embedded silicone bands. The disadvantage of nondegradable polymer inserts is to require for disposal of these bands after their use. The study currently focuses on preparation of biodegradable progesterone-incorporated nanofiber for estrus synchronization. Three different concentrations (1.2, 1.9, and 2.5 g) of progesterone-impregnated nanofibers were fabricated using electrospinning...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28227791/nonlinear-3-d-simulation-of-high-intensity-focused-ultrasound-therapy-in-the-kidney
#9
Visa Suomi, Jiri Jaros, Bradley Treeby, Robin Cleveland, Visa Suomi, Jiri Jaros, Bradley Treeby, Robin Cleveland, Jiri Jaros, Bradley Treeby, Robin Cleveland, Visa Suomi
Kidney cancer is a severe disease which can be treated non-invasively using high-intensity focused ultrasound (HIFU) therapy. However, tissue in front of the transducer and the deep location of kidney can cause significant losses to the efficiency of the treatment. The effect of attenuation, refraction and reflection due to different tissue types on HIFU therapy of the kidney was studied using a nonlinear ultrasound simulation model. The geometry of the tissue was derived from a computed tomography (CT) dataset of a patient which had been segmented for water, bone, soft tissue, fat and kidney...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227320/three-dimensional-modeling-of-physiological-tremor-for-hand-held-surgical-robotic-instruments
#10
Sivanagaraja Tatinati, Yan Naing Aye, Anand Pual, Wei Tech Ang, Kalyana C Veluvolu, Sivanagaraja Tatinati, Yan Naing Aye, Anand Pual, Wei Tech Ang, Kalyana C Veluvolu, Sivanagaraja Tatinati, Anand Pual, Wei Tech Ang, Yan Naing Aye, Kalyana C Veluvolu
Hand-held robotic instruments are developed to compensate physiological tremor in real-time while augmenting the required precision and dexterity into normal microsurgical work-flow. The hardware (sensors and actuators) and software (causal linear filters) employed for tremor identification and filtering introduces time-varying unknown phase-delay that adversely affects the device performance. The current techniques that focus on three-dimensions (3D) tip position control involves modeling and canceling the tremor in 3-axes (x, y, and z axes) separately...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227009/a-machine-learning-framework-for-auto-classification-of-imaging-system-exams-in-hospital-setting-for-utilization-optimization
#11
Meru A Patil, Ravindra B Patil, P Krishnamoorthy, Jacob John, Meru A Patil, Ravindra B Patil, P Krishnamoorthy, Jacob John, Meru A Patil, Jacob John, Ravindra B Patil, P Krishnamoorthy
In clinical environment, Interventional X-Ray (IXR) system is used on various anatomies and for various types of the procedures. It is important to classify correctly each exam of IXR system into respective procedures and/or assign to correct anatomy. This classification enhances productivity of the system in terms of better scheduling of the Cath lab, also provides means to perform device usage/revenue forecast of the system by hospital management and focus on targeted treatment planning for a disease/anatomy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226877/a-wearable-biofeedback-control-system-based-body-area-network-for-freestyle-swimming
#12
Rui Li, Zibo Cai, WeeSit Lee, Daniel T H Lai, Rui Li, Zibo Cai, WeeSit Lee, Daniel T H Lai, WeeSit Lee, Daniel T H Lai, Rui Li, Zibo Cai
Wearable posture measurement units are capable of enabling real-time performance evaluation and providing feedback to end users. This paper presents a wearable feedback prototype designed for freestyle swimming with focus on trunk rotation measurement. The system consists of a nine-degree-of-freedom inertial sensor, which is built in a central data collection and processing unit, and two vibration motors for delivering real-time feedback. Theses devices form a fundamental body area network (BAN). In the experiment setup, four recreational swimmers were asked to do two sets of 4 x 25m freestyle swimming without and with feedback provided respectively...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225866/circulating-myeloid-derived-suppressor-cells-predict-disease-activity-and-treatment-response-in-patients-with-immune-thrombocytopenia
#13
J Zhou, Y Zhou, J Wen, X Sun, X Zhang
Immune thrombocytopenia (ITP) is a disease characterized by isolated thrombocytopenia. Abnormal effector T cell activation is an important mechanism in the pathogenesis of ITP. Regulatory T cells (Treg) have a strong immunosuppressive function for T cell activation and their importance in the pathophysiology and clinical treatment of ITP has been confirmed. Myeloid-derived suppressor cells (MDSCs) are other immunosuppressive cells, which can also suppress T cell activation by secreting arginase, iNOS and ROS, and are essential for Treg cells' differentiation and maturation...
February 16, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28225819/lipid-interactions-and-angle-of-approach-to-the-hiv-1-viral-membrane-of-broadly-neutralizing-antibody-10e8-insights-for-vaccine-and-therapeutic-design
#14
Adriana Irimia, Andreia M Serra, Anita Sarkar, Ronald Jacak, Oleksandr Kalyuzhniy, Devin Sok, Karen L Saye-Francisco, Torben Schiffner, Ryan Tingle, Michael Kubitz, Yumiko Adachi, Robyn L Stanfield, Marc C Deller, Dennis R Burton, William R Schief, Ian A Wilson
Among broadly neutralizing antibodies to HIV, 10E8 exhibits greater neutralizing breadth than most. Consequently, this antibody is the focus of prophylactic/therapeutic development. The 10E8 epitope has been identified as the conserved membrane proximal external region (MPER) of gp41 subunit of the envelope (Env) viral glycoprotein and is a major vaccine target. However, the MPER is proximal to the viral membrane and may be laterally inserted into the membrane in the Env prefusion form. Nevertheless, 10E8 has not been reported to have significant lipid-binding reactivity...
February 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28225625/spin-orbit-coupling-effects-on-ligand-free-icosahedral-matryoshka-superatoms
#15
Feiyun Long, Haitao Liu, Dafang Li, Jun Yan
With the help of density functional theory, a series of matryoshka superatoms $\rm{X@Y_{12}@X_{20}}$ (X=Ge, Y=Zn; X=Sn, Y=Mg, Mn, Zn or Cd; X=Pb, Y= Mg, Mn, Cd or Hg) with icosahedral symmetry has been extensively studied, to focus on the influence of the spin-orbit coupling on geometries, stabilities, electronic structures and magnetic moments for these clusters. Generally speaking, the effect of spin-orbit coupling is highly correlated with composition elements of these clusters. $\rm{Ge@Zn_{12}@Ge_{20}}$ is little affected by the spin-orbit coupling, while clusters containing Sn atom will generally undergo a moderate influence on their atomization energy, HOMO-LUMO gap and projected density of states...
February 22, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28225131/modification-of-n-doped-tio2-photocatalysts-using-noble-metals-pt-pd-a-combined-xps-and-dft-study
#16
K Batalović, N Bundaleski, J Radaković, N Abazović, M Mitrić, R A Silva, M Savić, J Belošević-Čavor, Z Rakočević, C M Rangel
Nitrogen-doped TiO2 (N-TiO2) is considered as one of the most promising materials for various photocatalytic applications, while noble metals Pd and Pt are known as good catalysts for hydrogen evolution. This work focuses on the determination of structural and electronic modifications of N-TiO2, achieved by noble metal deposition at the surface, as a starting indicator for potential applications. We focus on the properties of easily synthesized nanocrystalline nitrogen-doped anatase TiO2, modified by depositing small amounts of Pd (0...
February 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28222724/financial-barriers-and-coping-strategies-a-qualitative-study-of-accessing-multidrug-resistant-tuberculosis-and-tuberculosis-care-in-yunnan-china
#17
C Hutchison, M S Khan, J Yoong, X Lin, R J Coker
BACKGROUND: Tuberculosis (TB) and multidrug-resistance tuberculosis (MDR-TB) pose serious challenges to global health, particularly in China, which has the second highest case burden in the world. Disparities in access to care for the poorest, rural TB patients may be exacerbated for MDR-TB patients, although this has not been investigated widely. We examine whether certain patient groups experience different barriers to accessing TB services, whether there are added challenges for patients with MDR-TB, and how patients and health providers cope in Yunnan, a mountainous province in China with a largely rural population and high TB burden...
February 22, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28220760/focused-electron-beam-induced-deposition-of-copper-with-high-resolution-and-purity-from-aqueous-solutions
#18
Samaneh Esfandiarpour, Lindsay Boehme, J Todd Hastings
Electron-beam induced deposition of high-purity copper nanostructures is desirable for nanoscale rapid prototyping, interconnection of chemically synthesized structures, and integrated circuit editing. However, metalorganic, gas-phase precursors for copper introduce high levels of carbon contamination. Here we demonstrate electron beam induced deposition of high-purity copper nanostructures from aqueous solutions of copper sulfate. The addition of sulfuric acid eliminates oxygen contamination from the deposit and produces a deposit with ∼95 at% copper...
February 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28217991/simultaneous-formation-and-spatial-patterning-of-zno-on-ito-surfaces-by-local-laser-induced-generation-of-microbubbles-in-aqueous-solutions-of-zn-nh3-4-2
#19
Sho Fujii, Ryuta Fukano, Yoshihito Hayami, Hiroaki Ozawa, Eiro Muneyuki, Noboru Kitamura, Masa-Aki Haga
We demonstrate the simultaneous formation and spatial patterning of ZnO nanocrystals on an indium-tin oxide (ITO) surface upon local heating using a laser (1064 nm) and subsequent formation of microbubbles. Laser irradiation of an ITO surface in aqueous [Zn(NH3)4](2+) solution (1.0 × 10(-2) M at pH = 12.0) under an optical microscope produced ZnO nanocrystals, the presence of which was confirmed by X-ray diffraction analysis and Raman microspectroscopy. Scanning the focused laser beam over the ITO surface generated a spatial ZnO pattern (height: ~60 nm, width: ~1 m) in the absence of a template or mask...
February 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28216063/the-nad-precursor-nicotinic-acid-improves-genomic-integrity-in-human-peripheral-blood-mononuclear-cells-after-x-irradiation
#20
Kathrin Weidele, Sascha Beneke, Alexander Bürkle
NAD(+) is an essential cofactor for enzymes catalyzing redox-reactions as well as an electron carrier in energy metabolism. Aside from this, NAD(+) consuming enzymes like poly(ADP-ribose) polymerases and sirtuins are important regulators involved in chromatin-restructuring processes during repair and epigenetics/transcriptional adaption. In order to replenish cellular NAD(+) levels after cleavage, synthesis starts from precursors such as nicotinamide, nicotinamide riboside or nicotinic acid to match the need for this essential molecule...
February 13, 2017: DNA Repair
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