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https://www.readbyqxmd.com/read/28812769/multiplex-coaxial-flow-focusing-for-producing-multicompartment-janus-microcapsules-with-tunable-material-compositions-and-structural-characteristics
#1
Qiang Wu, Chaoyu Yang, Guangli Liu, Wanghuai Xu, Zhiqiang Zhu, Ting Si, Ronald X Xu
We propose a simple but efficient multiplex coaxial flow focusing (MCFF) process for single-step fabrication of multicompartment Janus microcapsules (MJMs) in a wide range of operating parameters. The produced MJMs consist of a multicompartmental core-shell structure with material compositions tunable in individual shell and core compartments. Potential applications of such a MJM agent are demonstrated in both benchtop and in vitro experiments. For the benchtop experiment, magnetic nanoparticles are loaded into one of the shell compartments and photopolymerized under ultraviolet light for controlled alignment and rotation of the microcapsules in a magnetic field...
August 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28810405/a-case-control-study-of-psychosocial-factors-and-their-relationship-to-impairment-and-functionality-in-multiple-sclerosis
#2
Laia Briones-Buixassa, Raimon Milà, Francesc X Arrufat, Josep Mª Aragonès, Enric Bufill, Olivier Luminet, Rona Moss-Morris
The stress effect on multiple sclerosis remains unclear. Moderating psychosocial factors may be involved. This study compares some of them in people with multiple sclerosis and healthy controls, and their association with disease parameters. Coping style, social support, anxiety, alexithymia and early-life stress were measured, along with impairment and functionality. People with multiple sclerosis scored significantly higher on anxiety, alexithymia, and avoidance and instinctive coping but lower in social support...
February 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28809833/application-of-granger-causality-analysis-of-the-directed-functional-connection-in-alzheimer-s-disease-and-mild-cognitive-impairment
#3
Mei Wang, Zhengluan Liao, Dewang Mao, Qi Zhang, Yumei Li, Enyan Yu, Zhongxiang Ding
Impaired functional connectivity in the Default Mode Network (DMN) may be involved in the progression of Alzheimer's Disease (AD). The Posterior Cingulate Cortex (PCC) is a potential imaging marker for monitoring the progression of AD. Previous studies did not focus on the functional connectivity between the PCC and nodes in regions outside the DMN, but our study is an effort to explore these overlooked functional connections. For collecting data, we used functional Magnetic Resonance Imaging (fMRI) and Granger Causality Analysis (GCA)...
August 7, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28809680/high-performance-saw-resonator-on-new-multi-layered-substrate-using-litao3-crystal
#4
Tsutomu Takai, Hideki Iwamoto, Yuichi Takamine, Hisashi Yamazaki, Toshiyuki Fuyutsume, Haruki Kyoya, Takeshi Nakao, Hajime Kando, Masahiro Hiramoto, Takanori Toi, Masayoshi Koshino, Norio Nakajima
To develop the high performance filters and duplexers required for recent LTE frequency bands in mobile handsets, a surface acoustic wave (SAW) resonator is needed that have higher quality (Q) and a lower temperature coefficient of frequency (TCF). To achieve this, the authors focused on acoustic energy confinement in the depth direction for a rotated Y-X LiTaO3 (LT) substrate. Characteristics of multi-layered substrates with low impedance and high impedance layers under LT layer were studied numerically in terms of acoustic energy distribution, phase velocity, coupling coefficient and temperature characteristics employing a finite element method (FEM) simulation...
August 10, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28808322/neuroinflammation-alters-cellular-proteostasis-by-producing-endoplasmic-reticulum-stress-autophagy-activation-and-disrupting-erad-activation
#5
Cristina Pintado, Sandra Macías, Helena Domínguez-Martín, Angélica Castaño, Diego Ruano
Proteostasis alteration and neuroinflammation are typical features of normal aging. We have previously shown that neuroinflammation alters cellular proteostasis through immunoproteasome induction, leading to a transient decrease of proteasome activity. Here, we further investigated the role of acute lipopolysaccharide (LPS)-induced hippocampal neuroinflammation in cellular proteostasis. In particular, we focused on macroautophagy (hereinafter called autophagy) and endoplasmic reticulum-associated protein degradation (ERAD)...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807799/the-influence-of-yttrium-segregation-dependent-phase-partitioning-and-residual-stresses-on-the-aging-and-fracture-behaviour-of-3y-tzp-ceramics
#6
Dušan Bučevac, Tomaž Kosmač, Andraž Kocjan
The yttrium-segregation-dependent phase partitioning and residual stress development that influence both the aging and the fracture behaviour in 3Y-TZP bioceramics were studied by sintering alumina-free 3Y-TZP, varying the sintering temperature and the time, to yield ceramics with identical grain size distributions, but with different phase compositions. The structure and stability of the resulting tetragonal phases, in the form of transformable, yttria-lean t-ZrO2 (YLZ) and non-transformable, yttria-rich t"-ZrO2 and/or t'-ZrO2 (YRZ), were studied by X-ray diffraction (XRD) and focused ion beam scanning electron microscopy (FIB-SEM)...
August 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28804731/eye-tracking-in-catheter-based-cardiovascular-interventions-early-results
#7
Peter Lanzer, Mohammad Al-Naser, Syed Saqib Bukhari, Andreas Dengel, Elizabeth A Krupinski
Visual x-ray image processing (XRIP) represents a fundamental component of catheter-based cardiovascular interventions (CBCVIs). To date, no data are available to define XRIP in this setting. To characterize CBCVI XRIP, we developed a computer-based method allowing continuous temporal-spatial analysis of data recorded by a head-mounted eye-tracking device. Quantitative analysis of gaze duration of an expert operator (EO) revealed that the average time in minutes spent viewing the images on the display screen was [Formula: see text] and [Formula: see text] of the total recorded time in coronary angiography (CA) and in CA followed by CBCVI, respectively...
July 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28801001/examining-the-effects-of-a-home-based-palliative-heart-failure-program-on-quality-of-life-symptom-burden-satisfaction-with-care-and-caregiver-burden-among-patients-with-end-stage-heart-failure
#8
Alina Yee Man Ng, Frances Kam Yuet Wong
CONTEXT: Provision of home-based palliative care for seriously ill patients is important, yet few home-based palliative care services specifically or exclusively focus on end-stage heart failure (ESHF) patients. OBJECTIVES: This study aimed to examine the effect of a home-based palliative heart failure (HPHF) program on quality of life (QOL), symptoms burden, functional status, patient satisfaction and caregiver burden among patients with ESHF. METHODS: A two-group randomized controlled trial in three hospitals...
August 8, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28798900/recent-advances-in-unveiling-active-sites-in-molybdenum-sulfide-based-electrocatalysts-for-the-hydrogen-evolution-reaction
#9
REVIEW
Bora Seo, Sang Hoon Joo
Hydrogen has received significant attention as a promising future energy carrier due to its high energy density and environmentally friendly nature. In particular, the electrocatalytic generation of hydrogen fuel is highly desirable to replace current fossil fuel-dependent hydrogen production methods. However, to achieve widespread implementation of electrocatalytic hydrogen production technology, the development of highly active and durable electrocatalysts based on Earth-abundant elements is of prime importance...
2017: Nano Convergence
https://www.readbyqxmd.com/read/28797808/influence-of-buffer-solutions-in-the-adsorption-of-human-serum-proteins-onto-layered-double-hydroxide
#10
Diego R Gondim, Juan A Cecilia, Santângela O Santos, Thainá N B Rodrigues, José E Aguiar, Enrique Vilarrasa-García, Enrique Rodríguez-Castellón, Diana C S Azevedo, Ivanildo J Silva
The adsorption of human immunoglobulin G (IgG) and human serum albumin (HSA) on a non-calcined Mg-Al layered double hydroxide (3:1 Mg-Al LDH) was studied in batch and fixed bed experiments, focusing on the effect of buffer solution and pH over sorbent uptake. Mg-Al LDH was synthesized and characterized by X-ray diffraction (XRD), N2 adsorption-desorption isotherms at -196°C, X-ray photoelectron spectroscopy (XPS), Zero point charge (pHzpc), particle size distribution and Fourier transform infra-red (FTIR)...
August 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28796953/advanced-statistical-analyses-to-reduce-inconsistency-of-bond-strength-data
#11
T Minamino, A Mine, A Shintani, M Higashi, A Kawaguchi-Uemura, T Kabetani, R Hagino, D Imai, Y Tajiri, M Matsumoto, H Yatani
This study was designed to clarify the interrelationship of factors that affect the value of microtensile bond strength (µTBS), focusing on nondestructive testing by which information of the specimens can be stored and quantified. µTBS test specimens were prepared from 10 noncarious human molars. Six factors of µTBS test specimens were evaluated: presence of voids at the interface, X-ray absorption coefficient of resin, X-ray absorption coefficient of dentin, length of dentin part, size of adhesion area, and individual differences of teeth...
August 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28796927/epithelial-to-mesenchymal-transition-contributes-to-invasion-in-squamous-cell-carcinomas-originated-from-actinic-keratosis-through-the-differentiated-pathway-whereas-proliferation-plays-a-more-significant-role-in-the-classical-pathway
#12
X Saenz-Sardà, C Carrato, L Pérez-Roca, L Puig, C Ferrándiz, A Ariza, M T Fernández-Figueras
BACKGROUND: Every actinic keratosis (AK) starts with atypia at the basal layers of the epidermis (AK I). Progression into invasive squamous cell carcinoma (iSCC) may occur following two main pathways, classical and differentiated. In the former, iSCC only occurs after involvement of the upper epidermal layers by atypical cells (AK III), while in the latter iSCC develops directly from AK I. In the anogenital mucosa, these two pathways are associated with differential expression of p53 and p16...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28796169/cell-surface-and-nuclear-receptors-in-the-colon-as-targets-for-bacterial-metabolites-and-its-relevance-to-colon-health
#13
REVIEW
Sathish Sivaprakasam, Yangzom D Bhutia, Sabarish Ramachandran, Vadivel Ganapathy
The symbiotic co-habitation of bacteria in the host colon is mutually beneficial to both partners. While the host provides the place and food for the bacteria to colonize and live, the bacteria in turn help the host in energy and nutritional homeostasis, development and maturation of the mucosal immune system, and protection against inflammation and carcinogenesis. In this review, we highlight the molecular mediators of the effective communication between the bacteria and the host, focusing on selective metabolites from the bacteria that serve as messengers to the host by acting through selective receptors in the host colon...
August 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28795608/focus-small-to-find-big-the-microbeam-story
#14
Jinhua Wu, Tom K Hei
PURPOSE: Even though the first ultraviolet microbeam was described by S. Tschachotin back in 1912, the development of sophisticated micro-irradiation facilities only began to flourish in the late 1980s. In this article, we highlight significant microbeam experiments, describe the latest microbeam irradiator configurations and critical discoveries made by using the microbeam apparatus. MATERIALS AND METHODS: Modern radiological microbeams facilities are capable of producing a beam size of a few micrometers, or even tens of nanometers in size, and can deposit radiation with high precision within a cellular target...
August 10, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28792731/catalytic-enantioselective-carbonyl-allylation-and-propargylation-via-alcohol-mediated-hydrogen-transfer-merging-the-chemistry-of-grignard-and-sabatier
#15
Seung Wook Kim, Wandi Zhang, Michael J Krische
Merging the characteristics of transfer hydrogenation and carbonyl addition, we have developed a new class of catalytic enantioselective C-C bond formations. In these processes, hydrogen transfer between alcohols and π-unsaturated reactants generates carbonyl-organometal pairs that combine to deliver products of addition. On the basis of this mechanistic paradigm, lower alcohols are converted directly to higher alcohols in the absence of premetalated reagents or discrete alcohol-to-carbonyl redox reactions...
August 9, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28791702/developmental-neurotoxicity-of-the-organophosphorus-insecticide-chlorpyrifos-from-clinical-findings-to-preclinical-models-and-potential-mechanisms
#16
REVIEW
Richard D Burke, Spencer W Todd, Eric Lumsden, Roger J Mullins, Jacek Mamczarz, William P Fawcett, Rao P Gullapalli, William R Randall, Edna F R Pereira, Edson X Albuquerque
Organophosphorus (OP) insecticides are pest-control agents heavily used worldwide. Unfortunately, they are also well known for the toxic effects that they can trigger in humans. Clinical manifestations of an acute exposure of humans to OP insecticides include a well-defined cholinergic crisis that develops as a result of the irreversible inhibition of acetylcholinesterase (AChE), the enzyme that hydrolyzes the neurotransmitter acetylcholine (ACh). Prolonged exposures to levels of OP insecticides that are insufficient to trigger signs of acute intoxication, which are hereafter referred to as subacute exposures, have also been associated with neurological deficits...
August 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28791288/a-practical-approach-to-the-diagnosis-and-management-of-hair-loss-in-children-and-adolescents
#17
REVIEW
Liwen Xu, Kevin X Liu, Maryanne M Senna
Hair loss or alopecia is a common and distressing clinical complaint in the primary care setting and can arise from heterogeneous etiologies. In the pediatric population, hair loss often presents with patterns that are different from that of their adult counterparts. Given the psychosocial complications that may arise from pediatric alopecia, prompt diagnosis and management is particularly important. Common causes of alopecia in children and adolescents include alopecia areata, tinea capitis, androgenetic alopecia, traction alopecia, trichotillomania, hair cycle disturbances, and congenital alopecia conditions...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28790108/cyclophilin-a-maintains-glioma-initiating-cell-stemness-by-regulating-wnt-%C3%AE-catenin-signaling
#18
Guangzhi Wang, Jia Shen, Jiahang Sun, Zhenfeng Jiang, Jiabing Fan, Hongjun Wang, Shan Yu, Yu Long, Yi Liu, HOngbo Bao, Kelvin X Zhang, Ke Han, Min-Wei Zhu, Yongri Zheng, Zhiguo Lin, Chuanlu Jiang, Mian Guo
PURPOSE: Glioma-initiating cells (GICs) are glioma stem-like cells that contribute to glioblastoma (GBM) development, recurrence, and resistance to chemotherapy and radiotherapy. They have recently become the focus of novel treatment strategies. Cyclophilin A (CypA) is a cytosolic protein that belongs to the peptidyl-prolyl isomerase (PPIase) family and the major intracellular target of the immunosuppressive drug cyclosporin A (CsA). In this study, we investigate the functions of CypA and its mechanism of action in GICs' development...
August 8, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28783319/sharper-reaction-monitoring-generation-of-a-narrow-line-width-nmr-singlet-without-x-pulses-in-an-inhomogeneous-magnetic-field
#19
Ariana B Jones, Guy C Lloyd-Jones, Dusan Uhrin
We report a new 'pure-shift' method, termed 'SHARPER' (Sensitive, Homogeneous And Resolved PEaks in Real time) de-signed for the analysis of reactions and equilibria by NMR. By focusing on a single selected signal, SHARPER removes all heteronuclear couplings of a selected nucleus without the need to pulse on X channels, thus overcoming hardware limitations of conventional spectrometers. A more versatile decoupling scheme, termed 'sel-SHARPER', removes all heteronuclear and homonuclear couplings of the selected signal...
August 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28782411/on-road-assessment-of-fitness-to-drive-in-persons-with-ms-with-cognitive-impairment-a-prospective-study
#20
Sarah A Morrow, Sherrilene Classen, Miriam Monahan, Tim Danter, Robert Taylor, Sarah Krasniuk, Heather Rosehart, Wenqing He
BACKGROUND: Cognitive impairment is common in multiple sclerosis (MS). In other populations, cognitive impairment is known to affect fitness-to-drive. Few studies have focused on fitness-to-drive in MS and no studies have solely focused on the influence of cognitive impairment. OBJECTIVE: To assess fitness-to-drive in persons with MS with cognitive impairment and low physical disability. METHODS: Persons with MS, aged 18-59 years with EDSS ⩽ 4...
August 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
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