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https://www.readbyqxmd.com/read/29684268/conducting-polymers-for-tissue-engineering
#1
Baolin Guo, Peter X Ma
Electrically conducting polymers such as polyaniline, polypyrrole, polythiophene and their derivatives (mainly aniline oligomer and poly(3,4-ethylenedioxythiophene)) with good biocompatibility find wide applications in biomedical fields including bioactuators, biosensors, neural implants, drug delivery systems and tissue engineering scaffolds. This review focuses on these conductive polymers for tissue engineering application. Conductive polymers exhibited promising conductivity as bioactive scaffolds for tissue regeneration and their conductive nature allows cells or tissue cultured on them to be stimulated by electrical signals...
April 23, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29680625/ultrasonic-synthesis-of-hydroxyapatite-in-non-cavitation-and-cavitation-modes
#2
A L Nikolaev, A V Gopin, A V Severin, V N Rudin, M A Mironov, N V Dezhkunov
The size control of materials is of great importance in research and technology because materials of different size and shape have different properties and applications. This paper focuses on the synthesis of hydroxyapatite in ultrasound fields of different frequencies and intensities with the aim to find the conditions which allow control of the particles size. The results are evaluated by X-ray diffraction, Transmission Electron Microscopy, morphological and sedimentation analyses. It is shown that the hydroxyapatite particles synthesized at low intensity non-cavitation regime of ultrasound have smaller size than those prepared at high intensity cavitation regime...
June 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29680301/quantification-of-hydroxyl-radicals-and-solvated-electrons-produced-by-irradiated-gold-nanoparticles-suggests-a-crucial-role-of-interfacial-water
#3
Manon Gilles, Emilie Brun, Cécile Sicard-Roselli
The potential benefit of gold nanoparticles (GNP) to radiotherapy has been demonstrated in a range of cell lines and radiation sources as well as in rodent models, sometimes with contradictory results. Few experimental studies have explored the involved deleterious species, hydroxyl radical being so far the most cited, whereas theoretical studies have usually focused on secondary electrons emitted from GNP, making comparison between these two approaches difficult. Here we focus on the physico-chemical step (i...
April 5, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29680241/the-structure-function-relationship-in-antimicrobial-peptides-what-can-we-obtain-from-structural-data
#4
Marlon H Cardoso, Karen G N Oshiro, Samilla B Rezende, Elizabete S Cândido, Octávio L Franco
Antimicrobial peptides (AMPs) have been widely isolated from most organisms in nature. This class of antimicrobials may undergo changes in their sequence for improved physicochemical properties, including charge, hydrophobicity, and hydrophobic moment. It is known that such properties may be directly associated with AMPs' structural arrangements and, consequently, could interfere in their modes of action against microorganisms. In this scenario, biophysical methodologies, such as nuclear magnetic resonance spectroscopy, X-ray crystallography, and cryo-electron microscopy, allied to in silico approaches, including molecular modeling, docking, and dynamics nowadays represent an enormous first step for the structural elucidation of AMPs, leading to further structure-function annotation...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29679856/b7-h6-expression-is-induced-by-lipopolysaccharide-and-facilitates-cancer-invasion-and-metastasis-in-human-gliomas
#5
Fengyuan Che, Xiaoli Xie, Long Wang, Quanping Su, Feiyu Jia, Yufu Ye, Lanlan Zang, Jing Wang, Hongyan Li, Yanchun Quan, Cuiping You, Jiawei Yin, Zhiqiang Wang, Gen Li, Yifeng Du, Lijuan Wang
Although great progress has been made in treatment regimens, gliomas are still incurable and the 5-year survival remains poor. Studies focusing on molecules that regulate tumorigenesis or tumor immunity may provide potential therapeutic strategies for patients with glioma. B7-H6 is selectively expressed in tumor cells and plays vital roles in host immune responses. In this study, we demonstrated that B7-H6 was expressed in glioma cell lines, including CRT, U251, SHG-44, SF-295, TG-905 and U373, and tumor tissues isolated from glioma patients...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29678474/the-impact-of-body-awareness-on-women-s-sexual-health-a-comprehensive-review
#6
REVIEW
Brooke N Seal, Cindy M Meston
INTRODUCTION: Body awareness has been linked to female sexual response in laboratory manipulation studies and is used in clinical settings to ameliorate sexual difficulties. AIM: To evaluate and review the literature on body awareness and female sexual function. METHODS: A literature review was conducted through PsycInfo, PsycARTICLES, and PubMed using terms such as body awareness and sexual function. A manual search also was conducted using reference lists...
April 17, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29678281/an-orphan-g-protein-coupled-receptor-causes-human-gigantism-and-or-acromegaly-molecular-biology-and-clinical-correlations
#7
REVIEW
Giampaolo Trivellin, Laura C Hernández-Ramírez, Jeremy Swan, Constantine A Stratakis
X-linked acrogigantism (X-LAG) is a recently described form of familial or sporadic pituitary gigantism characterized by very early onset GH and IGF-1 excess, accelerated growth velocity, gigantism and/or acromegaloid features. Germline or somatic microduplications of the Xq26.3 chromosomal region, invariably involving the GPR101 gene, constitute the genetic defect leading to X-LAG. GPR101 encodes a class A G protein-coupled receptor that activates the 3',5'-cyclic adenosine monophosphate signaling pathway...
April 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29677823/photocatalytic-degradation-effect-of-%C3%AE-dielectric-barrier-discharge-plasma-treated-titanium-dioxide-nanoparticles-on-environmental-contaminant
#8
Hyeon Jin Seo, Ki-Hwan Hwang, Young Hoon Na, Jin-Hyo Boo
This study focused on the photocatalytic degradation effect of the μ-dielectric barrier discharge (μ-DBD) plasma treated titanium dioxide (TiO2) nanoparticles on environmental contaminant such as formaldehyde. TiO2 nanoparticles were treated by a μ-DBD plasma source with nitrogen gas. We analyzed the degradation of formaldehyde with the plasma treated TiO2 nanoparticles by UV-visible spectrophotometer (UV-VIS), and demonstrated that the photocatalytic activity of the μ-DBD plasma-treated TiO2 nanoparticles showed significantly high catalytic efficiency rather than without plasma treated TiO2 nanoparticles...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677727/feasibility-study-of-phosphor-screen-containing-nano-scale-anti-reflection-layer-for-improved-optical-properties-in-indirect-x-ray-detector
#9
Kyo-Tae Kim, Joo-Hee Kim, Ye-Ji Heo, Cheol-Ha Baek, Si-Cheol Noh, Yun-Seon Choi, Ki-Jung Ahn, Heung-Lae Cho, Chi-Woong Mun, Sung-Kwang Park
With increasingly strict regulations regarding patient exposure, research on digital radiography technology has recently focused on indirect methods that can produce high-quality images for a low radiation dose. In particular, medical imaging systems based on indirect methods universally use rare-earth metal phosphors, because of their high atomic number and excellent luminescence efficiency. Thus, various studies aiming to improve the luminescence efficiency of phosphors have been conducted. Despite this research, however, the current luminescence efficiencies are insufficient...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677380/end-of-life-education-and-discussions-with-assisted-living-certified-nursing-assistants
#10
Wendy L Mohlman, Kara Dassel, Katherine P Supiano, Michael Caserta
In previous work, the current researchers examined attitudes and experiences of certified nursing assistants (CNAs) providing end-of-life (EOL) care in an assisted living facility (ALF). Results showed that 70% of participating CNAs felt unprepared to provide EOL care, largely due to not having received prior EOL care education within their schools or workplaces. Therefore, the goal of the current study was to implement and evaluate EOL and postmortem education to ALF CNAs. A focus group of 14 CNAs within an ALF was provided EOL education pertaining to the physiological and psychological changes observed in patients nearing EOL and postmortem care...
April 19, 2018: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/29677183/divergent-genome-evolution-caused-by-regional-variation-in-dna-gain-and-loss-between-human-and-mouse
#11
Reuben M Buckley, R Daniel Kortschak, David L Adelson
The forces driving the accumulation and removal of non-coding DNA and ultimately the evolution of genome size in complex organisms are intimately linked to genome structure and organisation. Our analysis provides a novel method for capturing the regional variation of lineage-specific DNA gain and loss events in their respective genomic contexts. To further understand this connection we used comparative genomics to identify genome-wide individual DNA gain and loss events in the human and mouse genomes. Focusing on the distribution of DNA gains and losses, relationships to important structural features and potential impact on biological processes, we found that in autosomes, DNA gains and losses both followed separate lineage-specific accumulation patterns...
April 20, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29675672/low-virulence-bacterial-infections-in-cervical-intervertebral-discs-a-prospective-case-series
#12
Yilei Chen, Xianjun Wang, Xuyang Zhang, Hong Ren, Bao Huang, Jian Chen, Junhui Liu, Zhi Shan, Zhihai Zhu, Fengdong Zhao
STUDY DESIGN: A prospective cross-sectional case series study. OBJECTIVE: To investigate the prevalence of low virulence disc infection and its associations with characteristics of patients or discs in the cervical spine. BACKGROUND: Low virulence bacterial infections could be a possible cause of intervertebral disc degeneration and/or back pain. Controversies are continuing over whether these bacteria, predominantly Propionibacterium acnes (P...
April 19, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29675253/understanding-light-driven-h-2-evolution-through-the-electronic-tuning-of-aminopyridine-cobalt-complexes
#13
Arnau Call, Federico Franco, Noufal Kandoth, Sergio Fernández, María González-Béjar, Julia Pérez-Prieto, Josep M Luis, Julio Lloret-Fillol
A new family of cobalt complexes with the general formula [CoII (OTf)2 (Y,X PyMe tacn)] ( 1R , Y,X PyMe tacn = 1-[(4-X-3,5-Y-2-pyridyl)methyl]-4,7-dimethyl-1,4,7-triazacyclononane, (X = CN ( 1CN ), CO2 Et ( 1CO2Et ), Cl ( 1Cl ), H ( 1H ), NMe2 ( 1NMe2 )) where (Y = H, and X = OMe when Y = Me ( 1DMM )) is reported. We found that the electronic tuning of the Y,X PyMe tacn ligand not only has an impact on the electronic and structural properties of the metal center, but also allows for a systematic water-reduction-catalytic control...
March 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29672908/molecular-insights-into-trypanothione-reductase-inhibitor-interaction-a-structure-based-review
#14
REVIEW
Neha Tiwari, Neetu Tanwar, Manoj Munde
Information on how small molecules bind to the target enzyme has the potential to impact immensely on how medicinal chemists go about antiparasitic drug discovery. In this review, for the first time, we intend to make an assessment of the structural aspects of trypanothione reductase as drug target, and its complexes with several reversible drugs from the Protein Data Bank (PDB). We attempt to reveal the mechanism of these interactions by careful accounting of the X-ray structures and their possible roles in biological activity to treat Trypanosomatidae diseases...
April 19, 2018: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29667697/resources-for-psychiatric-clinicians-working-with-breastfeeding-mothers
#15
Nancy M Terres
In today's health care-focused climate, in which encouraging breastfeeding is part of national and international health care initiatives, clinicians in any field should have resources available for breastfeeding mothers. The current article provides information for psychiatric clinicians on how breastfeeding may affect women with psychiatric conditions, the type of lactation counselor likely to be best prepared to collaborate with psychiatric clinicians, and resources available regarding maternal psychiatric medications safe for breastfeeding infants...
April 17, 2018: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29667684/interaction-of-na-k-mg-2-and-ca-2-counter-cations-with-rna
#16
REVIEW
Stefan K Kolev, Petko St Petkov, Miroslav A Rangelov, Dimitar V Trifonov, Teodor I Milenov, Georgi N Vayssilov
Alkaline and alkaline earth ions, namely Na+, K+, Mg2+ and Ca2+, are critical for the stability, proper folding and functioning of RNA. Moreover, those metal ions help to facilitate macromolecular interactions as well as the formation of supramolecular structures (e.g. the ribosome and the ribozymes). Therefore, identifying the interactions between ions and nucleic acids is a key to the better comprehension of the physical nature and biological functions of those biomolecules. The scope of this review is to highlight the preferential location and binding sites of alkaline and alkaline earth metal ions compensating the negatively charged backbone of nucleic acids and interacting with other electronegative centers, focusing on RNA...
April 18, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29665214/an-analysis-of-clinical-transition-stresses-experienced-by-dental-students-a-qualitative-methods-approach
#17
M Botelho, X Gao, S Y Bhuyan
INTRODUCTION: Stress in dental students is well established with potential psychological distress, emotional exhaustion and burnout-related symptoms. Little attention has been given to the problems encountered by dental students during the transition from theoretical or paraclinical training to the clinical environment. The aim of this study was to adopt a qualitative research methods approach to understand the perceived stressors during students' clinical transition and provide insights for curriculum planners to enhance learning...
April 17, 2018: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29665068/osteoporosis-and-hip-fracture-risk-from-routine-computed-tomography-scans-the-fracture-osteoporosis-and-ct-utilization-study-focus
#18
Annette L Adams, Heidi Fischer, David L Kopperdahl, David C Lee, Dennis M Black, Mary L Bouxsein, Shireen Fatemi, Sundeep Khosla, Eric S Orwoll, Ethel S Siris, Tony M Keaveny
Methods now exist for analyzing previously taken clinical computed tomography (CT) scans to measure a dual-energy X-ray absorptiometry (DXA)-equivalent bone mineral density (BMD) at the hip and a finite element analysis-derived femoral strength. We assessed the efficacy of this "biomechanical CT" (BCT) approach for identifying patients at high risk of incident hip fracture in a large clinical setting. Using a case-cohort design sampled from 111,694 women and men aged 65 or older who had a prior hip CT scan, a DXA within 3 years of the CT, and no prior hip fracture, we compared those with subsequent hip fracture (n = 1959) with randomly selected sex-stratified controls (n = 1979) and analyzed their CT scans blinded to all other data...
April 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29664877/juvenile-osteochondritis-dissecans-of-the-trochlea-a-cohort-study-of-34-trochlear-lesions-associated-with-sporting-activities-that-load-the-patellofemoral-joint
#19
Meghan J Price, Maria Tuca, Joseph Nguyen, Jason Silberman, Eva Luderowski, Tyler J Uppstrom, Daniel W Green
BACKGROUND: Juvenile osteochondritis dissecans (JOCD) lesions are rarely located in the trochlea and few studies have focused on the causes and outcomes of JOCD lesions in this part of the knee. The purpose of this study is to (1) evaluate the clinical characteristics and outcomes of patients who undergo surgery for JOCD in this unusual location as well as (2) assess the association between trochlear JOCD and participation in sporting activities that load the patellofemoral joint. METHODS: We conducted a retrospective cohort study of 34 trochlear JOCD lesions in 30 patients...
April 16, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29662983/the-recognition-of-glycans-by-protein-receptors-insights-from-nmr-spectroscopy
#20
Ana Ardá, Jesús Jiménez-Barbero
Carbohydrates (glycans, saccharides, sugars) are everywhere. In fact, glycan-protein interactions are involved in many essential processes of life and disease. The understanding of the key structural details at the atomic and molecular level is of paramount importance to effectively design molecules for therapeutic purposes. Different approximations may be employed to decipher these molecular recognition processes with high resolution. Advances in cryo-electron microscopy are providing exquisite details on different biological mechanisms involving sugars, while better and better protocols for structural refinement in the application of X-ray methods for protein-sugar complexes and glycoproteins are also permitting fantastic advances in the glycoscience arena...
April 17, 2018: Chemical Communications: Chem Comm
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