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https://www.readbyqxmd.com/read/29447628/sexual-side-effects-of-5-%C3%AE-reductase-inhibitors-finasteride-and-dutasteride-a-comprehensive-review
#1
Raymond M Fertig, A Caresse Gamret, Evan Darwin, Sudeep Gaudi
The 5-α-reductase inhibitors finasteride and dutasteride are frequently used in the treatment of androgenetic alopecia and benign prostatichyperplasia. These drugs are effective at reducing levels of dihydrotestosterone, the primary androgen responsible for the pathogenesis of both these conditions. However, finasteride and dutasteride have also been shown to produce an increase in the incidence of sexual dysfunction, namely, impotence, decreased libido, and ejaculation disorder. The purpose of this study is to review the existing medical literature with regard to the sexual side effects of 5-α-reductase inhibitor therapy...
November 11, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29444462/photodynamic-therapy-as-a-new-approach-to-trichomonas-vaginalis-inactivation
#2
Thaisa Helena Silva Fonseca, Marina Alacoque, Fabrício Marcus Silva Oliveira, Betânia Maria Soares, Henrique Vitor Leite, Marcelo Vidigal Caliari, Maria Aparecida Gomes, Haendel Busatti
The emergence of nitroimidazole resistant isolates has been an aggravating factor in the treatment of trichomoniasis, the most common non-viral sexually transmitted disease in the world. This particularity highlights the importance of new technologies that are safe, effective, and have minor side effects or resistance. Hence, we evaluated the effectiveness of photodynamic therapy on the inactivation of Trichomonas vaginalis in vitro. We used methylene blue as a photosensitizing substance, and a light-emitting diode (LED) for irradiation of metronidazole sensitive and resistant strains...
February 11, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29437542/quality-of-life-questionnaires-in-breast-cancer-related-lymphedema-patients-review-of-the-literature
#3
Anouk J M Cornelissen, Melissa Kool, Xavier H A Keuter, Esther M Heuts, Andrzej A Piatkowski de Grzymala, René R W J van der Hulst, Shan Shan Qiu
PURPOSE: Lymphedema of the arm is one of the most common and underestimated side effects of breast cancer treatment. It is known to negatively affect the quality of life (QoL) in breast cancer survivors. However, there are multiple questionnaires used to measure QoL in lymphedema patients. The current study aimed to determine the most complete and accurate questionnaire. METHODS: A systematic literature search in Cochrane Library database CENTRAL, MEDLINE, and EMBASE was conducted in August 2016 by two independent researchers...
February 13, 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29435794/emergency-contraceptive-pills-ecp-knowledge-attitudes-and-practices-among-women-working-in-the-entertainment-industry-and-men-in-the-trucking-industry-bhutan
#4
Deki Pem, Tshewang Nidup, Ugyen Wangdi, Dorji Pelzom, Ali Mirzazadeh, Willi McFarland
Emergency contraceptive pills (ECP) were recently made available over the counter in Bhutan. We evaluated knowledge, attitudes, and practices concerning ECP in 2 populations at risk for HIV and STI (sexually transmitted infections): entertainment women (drayang) and male truck drivers and helpers (truckers). Of 179 drayang and 437 truckers intercepted at venues, 73.7 and 21.1%, respectively, had heard of ECP; 47.0% of drayang had used them. Their concerns about ECP use included harm to the body, impact on future pregnancy, side effects, and HIV/STI risk...
February 12, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29433012/talking-about-male-body-based-contraceptives-the-counseling-visit-and-the-feminization-of-contraception
#5
Katrina Kimport
In developed countries, women bear the primary, and sometimes exclusive, responsibility for preventing pregnancy in heterosexual sexual relations. This unequal burden is not an intrinsic fact; it is the consequence of broad social narratives and interpersonal negotiations. The contraceptive counseling visit is increasingly recognized as a site of the discursive production of normative ideas about reproduction, suggesting that clinicians themselves may contribute to the assignment of responsibility for contraceptive labor to women (i...
February 2, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29430767/sexual-function-psychosocial-adjustment-to-illness-and-quality-of-life-among-chinese-gynaecological-cancer-survivors
#6
Ka Ming Chow, Winnie Kwok Wei So, Kai Chow Choi, Carmen Wing Han Chan
BACKGROUND: Disrupted sexual function is a prevalent and sustained side effect of gynaecological cancer and its related treatment. This problem may pose challenges to the survivors in the process of illness adjustment, leading to elevated psychological distress and impaired quality of life. However, care and interventions in this area have been neglected in most countries. OBJECTIVES: To investigate sexual function, psychosocial adjustment to illness and quality of life among Chinese gynaecological cancer survivors in Hong Kong, and to explore their associations...
February 12, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29430679/seeking-certainty-through-narrative-closure-men-s-stories-of-prostate-cancer-treatments-in-a-state-of-liminality
#7
Ilkka Pietilä, Raisa Jurva, Hanna Ojala, Teuvo Tammela
Radical treatments of prostate cancer often lead to a pervasive liminal state that is characterised by multiple uncertainties that relate both to a possible recurrence of cancer and recovery from side effects, such as erectile and urinary dysfunctions. Liminality can make it difficult for cancer patients to narrate their experiences, as their stories lack a definite ending. After interviews with 22 Finnish men who had undergone radical prostatectomy, we analysed how men produce closure in their illness narratives...
February 11, 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29426693/clinical-needs-assessment-for-sexual-health-among-cancer-patients-receiving-pelvic-radiation-implications-for-development-of-a-radiation-oncology-sexual-health-clinic
#8
Jennifer Y Wo, Lorraine C Drapek, Andrzej Niemierko, Brenda Silvia, Bridget N Noé, Andrea L Russo, David T Miyamoto, Theodore S Hong, Jason A Efstathiou, Anthony L Zietman, Don S Dizon
BACKGROUND: Cancer patients treated with pelvic radiation therapy (RT) often experience sexual health-related side effects during and following treatment. A clinical needs assessment was used to evaluate sexual health needs and to determine how needs differed between patients receiving and who had completed RT. METHODS AND MATERIALS: A questionnaire was used to evaluate sexual health needs among patients treated with pelvic RT. All answers were rated using a 4-point Likert scale...
November 21, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29405168/penile-sensory-thresholds-in-subtypes-of-premature-ejaculation-implications-of-comorbid-erectile-dysfunction
#9
Xiang Chen, Fei-Xiang Wang, Chao Hu, Nian-Qin Yang, Ji-Can Dai
Penile hypersensitivity plays an important role in premature ejaculation (PE), but differences in penile sensitivity among subtypes of PE are unknown. Therefore, we compared penile sensory thresholds in PE subtypes of lifelong and acquired PE, PE with and without erectile dysfunction (ED), PE with an intravaginal ejaculation latency time ≤1 min and >1 min, and PE with and without orgasmic pleasure perceptual dysfunction. During August 2014 to January 2016, 136 patients with PE were included. Penile warm, cold, and vibratory thresholds were measured...
February 6, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29403128/add-on-aripiprazole-for-atypical-antipsychotic-induced-clinically-significant-hyperprolactinemia
#10
Dhanya Raveendranthan, Naren P Rao, Mukund G Rao, Ajish G Mangot, Shivaram Varambally, Muralidharan Kesavan, Ganesan Venkatasubramanian, Bangalore N Gangadhar
Background: Antipsychotic treatment-induced hyperprolactinemia is a highly distressing and disabling side effect for patients. The use of add-on aripiprazole has been identified as a possible treatment strategy in this situation. However, data on prolactin changes with add-on aripiprazole in a real-world naturalistic clinical setting from India are sparse. Materials and Methods: The retrospective chart review was conducted at the specialty metabolic clinic at the National Institute of Mental Health and Neurosciences, Bengaluru, India...
January 2018: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29402232/evolution-of-quality-of-life-in-patients-with-breast-cancer-during-the-first-year-of-follow-up-in-morocco
#11
B M Traore, S El Fakir, H Charaka, N Benaicha, A Najdi, A Zidouh, M Bennani, H Errihani, N Mellass, A Benider, R Bekkali, C Nejjari
BACKGROUND: Quality of life has an important place in the future of patients with breast cancer. The objective of this study is to assess the evolution of the patient's quality of life with breast cancer in Morocco after a year of follow-up. METHODS: This study involved the patients with breast cancer with all types of treatment as determined by their physicians. Patient's quality of life was assessed with the Moroccan Arabic version of QLQ- EORTC QLQ C30 and EORTC-BR23 questionnaires...
February 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29397680/user-perspectives-on-implanon-nxt-in-south-africa-a-survey-of-12-public-sector-facilities
#12
D Pillay, Matthew Chersich, C Morroni, M Pleaner, O Adeagbo, N Naidoo, S Mullick, H Rees
Background. Implanon NXT, a long-acting reversible contraceptive, was introduced in South Africa (SA) in early 2014, aiming to expand the method mix and increase its effectiveness. Initial uptake was high, but has since declined considerably. In these early years after the implant’s introduction, it is important to identify reasons for the decline, and remedy gaps in services. Objectives. To determine periods of use, reasons for the use and early removal of the implant Implanon NXT. Methods. In 2016, we recruited 152 women from six clinics in the City of Johannesburg, and six in North West Province, SA...
October 1, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29396283/urological-survivorship-issues-among-adolescent-boys-and-young-men-who-are-cancer-survivors
#13
REVIEW
Troy Sukhu, Sherry Ross, R Matthew Coward
BACKGROUND: Urological survivorship issues encompass an area that may potentially be overlooked after treatment of childhood cancer in adolescent boys and young men. Side effects of cancer therapy may include subsequent development of erectile dysfunction (ED), hypogonadism, and infertility in adulthood. AIM: The purpose of this review is to focus on the etiology and prevalence of the range of sexual and gonadal dysfunction in adolescent boys and young men who are cancer survivors, while discussing current recommendations for evaluation and treatment...
January 27, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29396020/low-intensity-shockwave-therapy-for-erectile-dysfunction-a-randomized-clinical-trial-comparing-2-treatment-protocols-and-the-impact-of-repeating-treatment
#14
Dimitrios Kalyvianakis, Evangelos Memmos, Ioannis Mykoniatis, Paraskevi Kapoteli, Dimitrios Memmos, Dimitrios Hatzichristou
BACKGROUND: There is lack of evidence-based optimization of the protocol for low-intensity shockwave therapy for erectile dysfunction. Furthermore, the safety and efficacy of repeating shockwave therapy have not been explored. AIM: To compare the efficacy and safety of 6 and 12 treatment sessions within a 6-week treatment period and investigate the effect of repeat treatment after a 6-month period in a 2-phase study. METHODS: Patients with vasculogenic erectile dysfunction that responded to phosphodiesterase type 5 inhibitors were randomized into 2 groups: low-intensity shockwave therapy sessions once (group A, n = 21) or twice (group B, n = 21) per week for 6 consecutive weeks (phase 1)...
January 27, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29385738/chloro-1-4-dimethyl-9h-carbazole-derivatives-displaying-anti-hiv-activity
#15
Carmela Saturnino, Fedora Grande, Stefano Aquaro, Anna Caruso, Domenico Iacopetta, Maria Grazia Bonomo, Pasquale Longo, Dominique Schols, Maria Stefania Sinicropi
BACKGROUND: Despite the progress achieved by anti-retroviral drug research in the last decades, the discovery of novel compounds endowed with selective antiviral activity and reduced side effects is still a necessity. At present, the most urgent requirement includes the improvement of HIV (Human Immunodeficiency Virus) prevention and sexual transmission and the development of new drugs to treat the chronic lifelong infection. METHODS: Six chloro-1,4-dimethyl-9H-carbazoles (2a,b-4a,b) have been prepared following opportunely modified known chemical procedures and tested in luciferase and Escherichia coli β-galactosidase expressing CD4⁺, CXCR4⁺, CCR5⁺ TZM-bl cells...
January 30, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29376616/-laser-therapy-for-mens-infertility-part-2-systematic-review-of-clinical-trials
#16
O I Apolikhin, S V Moskvin
Male infertility is a multifactorial syndrome associated with a wide range of pathological conditions affecting both the sexual and other body systems: endocrine, nervous, blood, and immune. Laser therapy is a form of modern physiotherapy that applies low-intensity laser irradiation (LILI) in various parts of the body. It is widely used in all areas of modern medicine due to its high efficiency, ease of use, the absence of contraindications and side effects. The authors reviewed the results of 171 studies investigating laser therapy, of which 93 were experimental (20 in Russian and 73 international publications), four clinical and experimental (all in Russian), 74 clinical (73 in Russian and 1 in English)...
December 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29355224/rationale-and-design-of-a-multi-center-open-label-randomised-clinical-trial-comparing-hiv-incidence-and-contraceptive-benefits-in-women-using-three-commonly-used-contraceptive-methods-the-echo-study
#17
G Justus Hofmeyr, Charles S Morrison, Jared M Baeten, Tsungai Chipato, Deborah Donnell, Peter Gichangi, Nelly Mugo, Kavita Nanda, Helen Rees, Petrus Steyn, Douglas Taylor
BACKGROUND: In vitro, animal, biological and observational clinical studies suggest that some hormonal methods, particularly depot medroxyprogesterone acetate - DMPA, may increase women's risk of HIV acquisition. DMPA is the most common contraceptive used in many countries worst affected by the HIV epidemic. To provide robust evidence for contraceptive decision-making among women, clinicians and planners, we are conducting the Evidence for Contraceptive Options and HIV Outcomes (ECHO) study in four countries with high HIV incidence and DMPA use: Kenya, South Africa, Swaziland, and Zambia (Clinical Trials...
December 29, 2017: Gates Open Res
https://www.readbyqxmd.com/read/29352696/safety-and-efficacy-of-prostatic-artery-chemoembolization-for-prostate-cancer-initial-experience
#18
João Pisco, Tiago Bilhim, Nuno V Costa, Manuel Pinto Ribeiro, Lucia Fernandes, António G Oliveira
PURPOSE: To evaluate outcome of prostatic artery chemoembolization for patients with prostate cancer (PCa). MATERIALS AND METHODS: This single-center prospective cohort study was conducted between August 2013 and July 2016 in 20 patients with PCa who underwent chemoembolization. Mean patient age was 67.5 years ± 6.4. Gleason score was 6-10, and staging was T2N0M0. Fifteen patients refused prostatectomy and 5 wanted to stop hormonal therapy because of side effects...
January 15, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29350154/use-of-pristinamycin-for-macrolide-resistant-mycoplasma-genitalium-infection
#19
Tim R H Read, Jørgen S Jensen, Christopher K Fairley, Mieken Grant, Jennifer A Danielewski, Jenny Su, Gerald L Murray, Eric P F Chow, Karen Worthington, Suzanne M Garland, Sepehr N Tabrizi, Catriona S Bradshaw
High levels of macrolide resistance and increasing fluoroquinolone resistance are found in Mycoplasma genitalium in many countries. We evaluated pristinamycin for macrolide-resistant M. genitalium in a sexual health center in Australia. Microbiologic cure was determined by M. genitalium-specific 16S PCR 14-90 days after treatment began. Of 114 persons treated with pristinamycin, infection was cured in 85 (75%). This percentage did not change when pristinamycin was given at daily doses of 2 g or 4 g or at 3 g combined with 200 mg doxycycline...
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29344340/assessment-and-management-of-sexual-dysfunction-in-the-context-of-depression
#20
REVIEW
Pratap R Chokka, Jeffrey R Hankey
Sexual dysfunction (SD) is pervasive and underreported, and its effects on quality of life are underestimated. Due in part to its bidirectional relationship with depression, SD can be difficult to diagnose; it is also a common side effect of many antidepressants, leading to treatment noncompliance. While physicians often count on patients to spontaneously report SD, treatment is optimized when the clinician instead performs a thorough assessment of sexual functioning before and during drug therapy using a standardized questionnaire such as the Arizona Sexual Experiences Scale (ASEX)...
January 2018: Therapeutic Advances in Psychopharmacology
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