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Sexual side effects

Alex Borchert, David A Leavitt
PURPOSE OF REVIEW: Review how the various surgical treatments for benign prostatic hyperplasia and lower urinary tract symptoms impact on male sexual health and function. RECENT FINDINGS: The interplay between benign prostatic hyperplasia and erectile function is complex, and the conditions seem linked. Most cavitating procedures to improve male voiding will degrade ejaculatory and possibly erectile function. Many of the newer minimally invasive therapies appear to preserve sexual function in the short term while sacrificing some of the voiding improvements realized with more complete removal of the prostate adenoma...
June 19, 2018: Current Urology Reports
Eliza Govender, Quarraisha Abdool Karim
Despite significant advances to the HIV epidemic, prevention remains a challenge globally. Adolescent girls and young women in southern and Eastern Africa are still at high risk of acquiring HIV infection with limited prevention options. The expanding product pipeline of novel drugs and delivery approaches has highlighted the importance of acceptability and uptake of these anti-retroviral based products to realize their full prevention potential. Community engagement is now imperative to inform both product development and uptake; with research directed to understand what potential users are willing to use given the broader cultural-gender context in which HIV prevention product choices are made/negotiated...
June 18, 2018: AIDS Care
M Faya, C Marchetti, M Priotto, M Grisolía, F D'Francisco, C Gobello
The objective of this study was to assess the efficiency and clinical safety of postnatal administration of a GnRH agonist on canine puberty postponement. Sexual steroids and histological gonadal changes were also described. Twenty-four littermate puppies were randomly assigned to: Deslorelin acetate 18.8 mg sc (DESLO; n = 12) or Placebo: sc (PLACE; n = 12) postnatally. The dogs were clinically and endocrinologically followed up until puberty when they were gonadectomized and their gonads histomorphometrically studied...
June 2, 2018: Theriogenology
Eric P Raffin, Kristina L Penniston, Jodi A Antonelli, Davis P Viprakasit, Timothy D Averch, Vincent G Bird, Ben H Chew, Sri Sivalingam, Roger L Sur, Stephen Y Nakada, Vernon M Pais
INTRODUCTION: It is unknown whether benefits of medical management of urolithiasis outweigh potential side effects of utilized medications including potassium citrate (Kcit) and thiazide diuretics. Therefore, we sought to evaluate the relationship between Kcit or thiazides and overall stone-related health related quality of life (HRQOL). METHODS: Using cross-sectional data from stone forming enrollees in the North American Stone Quality of Life Consortium, we used the Wisconsin Stone Quality of Life questionnaire (WISQOL) to compare HRQOL between patients treated and not treated with Kcit or thiazide type diuretics...
June 15, 2018: Journal of Urology
Jane M Ussher, Janette Perz, Duncan Rose, Andrew Kellett, Gary Dowsett
The use of assistive aids in sexual rehabilitation after prostate cancer (PCa) was examined in 124 gay, bisexual, and other men who have sex with men (GBM) and 225 heterosexual men. GBM were significantly more likely to use assistive aids (79% versus 56%), to try multiple assistive aids (M = 1.65 versus M = 0.83) including medication, penile injection, penile implant, vacuum pump, and nonmedical sex aids, and to seek information about sexual rehabilitation on the Internet, through counseling, or in a support group...
June 18, 2018: Journal of Sex Research
Evelyne Kestelyn, Jennifer Ilo Van Nuil, Marie Michelle Umulisa, Grace Umutoni, Alice Uwingabire, Lambert Mwambarangwe, Mireille Uwineza, Stephen Agaba, Tania Crucitti, Janneke van de Wijgert, Thérèse Delvaux
BACKGROUND: Introduction of contraceptive vaginal rings (CVRs) could expand the contraceptive method mix reducing the unmet need for family planning in Rwanda, but data on acceptability of CVRs from low and middle-income countries are lacking. METHODS: This study explores acceptability of contraceptive vaginal ring (NuvaRing) use in Kigali, Rwanda using a mixed methods approach. We collected quantitative and qualitative data before, during and after conducting a clinical trial, using Case Report Forms, Interviewer Administered Questionnaires, In Depth Interviews and Focus Group Discussions...
2018: PloS One
Mohammed A Said, Akanksha Mehta
PURPOSE OF REVIEW: Male pattern hair loss, mediated by dihydrotestosterone, is a common hair loss disorder, affecting over 50% of men over the age of 50. The 5-α reductase inhibitors, finasteride and dutasteride, are Food and Drug Administration-approved drugs for the treatment of this disorder. Several recent studies have reported adverse sexual and spermatogenic events among young men using 5-α reductase inhibitors, such as erectile dysfunction, decreased ejaculate volume, decreased libido, and infertility...
June 16, 2018: Current Urology Reports
Frank J Penedo, Michael H Antoni, Patricia I Moreno, Lara Traeger, Dolores Perdomo, Jason Dahn, Gregory E Miller, Steve Cole, Julian Orjuela, Edgar Pizarro, Betina Yanez
Almost 2.8 million men in the U.S. are living with prostate cancer (PC), accounting for 40% of all male cancer survivors. Men diagnosed with prostate cancer may experience chronic and debilitating treatment side effects, including sexual and urinary dysfunction, pain and fatigue. Side effects can be stressful and can also lead to poor psychosocial functioning. Prior trials reveal that group-based cognitive behavioral stress and self-management (CBSM) is effective in reducing stress and mitigating some of these symptoms, yet little is known about the effects of culturally-translated CBSM among Spanish-speaking men with PC...
June 14, 2018: Contemporary Clinical Trials
Beric M Gilbert, Annemariè Avenant-Oldewage
Parasites of fishes have been shown to be effective bioindicators of the aquatic environment. Few investigations have been conducted on ectoparasite models and therefore little is known about the fate of trace elements and metals which they accumulate. In this study trace element sequestration was observed in the carapace of the fish louse, Argulus japonicus and found to relate to the sex of the parasite, as well as, the degree of sclerotization of the carapace. Adults of A. japonicus were collected from cyprinid hosts in the Vaal Dam, South Africa...
2018: PloS One
Tahereh Molkara, Farideh Akhlaghi, Mohammad Arash Ramezani, Roshanak Salari, Veda Vakili, Mohammad Kamalinejad, Mohammad Reza Fayyazi Bordbar, Ahmad Ghorbani, Malihe Motavasselian
Background: Globally, female sexual dysfunction is a serious concern based on negative family and social consequences, high side effects of medications and lack of effective treatment. Thus, the evaluation of treatment approach for this problem is an important priority for healthcare systems. Sexual life and its related disorders are considered the main aspects of a healthy lifestyle in traditional Persian medicine (TPM). Objective: The present study aimed to determine and compare the effects of food products containing Daucus carota, TPM-based training program, and a combination of these two interventions on the improvement of female sexual dysfunction...
April 2018: Electronic Physician
Kavitha Ganesan, Yacob Habboush, Senan Sultan
Female hypoactive sexual desire disorder (HSDD) is a multifactorial sexual dysfunction disorder characterized by a decrease in sexual desire and personal distress. HSDD occurs in naturally occurring postmenopausal women or secondary to oophorectomy. Multiple studies have assessed the use of transdermal testosterone (TDT) as a management option for patients with HSDD. Our aim is to assess published studies using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework for the quality of evidence regarding testosterone use as a short- and long-term therapy for HSDD...
March 31, 2018: Curēus
Marieke van Leeuwen, Olga Husson, Paola Alberti, Juan Ignacio Arraras, Olivier L Chinot, Anna Costantini, Anne-Sophie Darlington, Linda Dirven, Martin Eichler, Eva B Hammerlid, Bernhard Holzner, Colin D Johnson, Meropi Kontogianni, Trille Kristina Kjær, Ofir Morag, Sandra Nolte, Andrew Nordin, Andrea Pace, Monica Pinto, Katja Polz, John Ramage, Jaap C Reijneveld, Samantha Serpentini, Krzysztof A Tomaszewski, Vassilios Vassiliou, Irma M Verdonck-de Leeuw, Ingvild Vistad, Teresa E Young, Neil K Aaronson, Lonneke V van de Poll-Franse
BACKROUND: The number of cancer survivors is growing steadily and increasingly, clinical trials are being designed to include long-term follow-up to assess not only survival, but also late effects and health-related quality of life (HRQOL). Therefore it is is essential to develop patient-reported outcome measures (PROMs) that capture the full range of issues relevant to disease-free cancer survivors. The objectives of this project are: 1) to develop a European Organisation for Research and Treatment of Cancer (EORTC) questionnaire that captures the full range of physical, mental and social HRQOL issues relevant to disease-free cancer survivors; and 2) to determine at which minimal time since completion of treatment the questionnaire should be used...
June 4, 2018: Health and Quality of Life Outcomes
John Read, James Williams
BACKGROUND: Studies of the adverse effects of antidepressants tend to focus on biological symptoms. The prevalence of suicidality and withdrawal effects are currently a source of controversy. OBJECTIVE: To directly ascertain the experiences of an international sample of antidepressant users. METHOD: An online survey asked adult antidepressant users whether they had experienced 20 adverse effects 'as a result of taking the antidepressant', and if so, to what degree of severity...
June 4, 2018: Current Drug Safety
Abdulla Homayuonfar, Alireza Aminsharifi, Alireza Salehi, Ali Sahraian, Shadab Dehshari, Mohsen Bahrami
Background: This randomized clinical trial was aimed to evaluate the effect of oral use of tamarind seed powder as an herbal product in patients affected by premature ejaculation (PE). Materials and Methods: In this study, 75 patients randomized in tamarind group (25 patients received daily 130 mg tamarind seed powder), paroxetine group (25 patients received daily 20 mg paroxetine), and placebo group (25 patients). Patients received the treatment regimen for 4 weeks...
2018: Advanced Biomedical Research
Leonessa Boing, Fátima Baptista, Gustavo Soares Pereira, Fabiana Flores Sperandio, Jéssica Moratelli, Allana Alexandre Cardoso, Adriano Ferreti Borgatto, Adriana Coutinho de Azevedo Guimarães
OBJECTIVE: To analyse the influence of belly dance on the quality of life, fatigue, and depressive symptoms in women with breast cancer. METHODS: Pilot study, with a design of non-randomised clinical trial study, analysing 19 women, with 8 allocated in the experimental group and 11 in the control group. The experimental group underwent 12 weeks of belly dance classes, with a frequency of twice a week and duration of 60 min for each lesson. Data collection was made through the use of questionnaires containing general information, quality of life (EORTC QLQ-BR23), fatigue (Piper Fatigue Scale) and depressive symptoms (BECK's Depression Inventory) applied on baseline and after intervention...
April 2018: Journal of Bodywork and Movement Therapies
Sydney E Ashton, Ben J Vernasco, Ignacio T Moore, M Rockwell Parker
Estrogens are important regulators of reproductive physiology including sexual signal expression and vitellogenesis. For the regulation to occur, the hormone must bind and activate receptors in target tissues, and expression of the receptors can vary by sex and/or season. By simultaneously comparing circulating hormone levels with receptor expression, a more complete understanding of hormone action can be gained. Our study species, the red-sided garter snake (Thamnophis sirtalis parietalis), provides an excellent opportunity to study the interaction between sex steroid hormones and receptor expression in addition to sexual dimorphism and seasonality...
May 25, 2018: General and Comparative Endocrinology
Malte Rieken, Tiago Antunes-Lopes, Bogdan Geavlete, Tom Marcelissen
Transurethral resection of the prostate as well as laser prostatectomy (by either holmium laser enucleation of the prostate or Greenlight laser vaporization) is associated with risks of sexual dysfunction such as antegrade ejaculation and occasionally erectile dysfunction. While ejaculation-sparing variations of these techniques show promising results, larger multicenter studies are needed to confirm promising data. Prostatic urethral lift maintains erectile and ejaculatory function at 5-yr follow-up. The same is true for the 3-yr data on the Rezum system...
May 23, 2018: European Urology Focus
Mustafa Suat Bolat, Onder Cinar, Ekrem Akdeniz, Ramazan Aşcı
The aim was to compare the differences between daily 5 mg and on-demand 20 mg tadalafil use in diabetic patients with erectile dysfunction (ED), and the effects of two different tadalafil protocols on ejaculatory and lower urinary tract symptoms (LUTS). Of the 63 diabetic patients with ED, 31 were given 5 mg tadalafil once a day, and 32 were given 20 mg tadalafil on-demand four times a month over three months. Erectile function, erectile hardness, ejaculatory function, and LUTS were assessed at pretreatment, first- and third-month controls...
May 25, 2018: International Journal of Impotence Research
Jeanette Martins, Brijesh S
Stress renders an individual to experience mental pressure and exhaustion which brings about feelings of anxiety, depression, anger and/or other negative emotions. Depression affects a person's state of mind, behaviour, health and is often associated with suicide. The use of anti-depressant drugs as therapeutic agents is associated with symptoms such as, delayed onset of action, side-effects, drug-drug and dietary interactions, sexual dysfunction, cardiac toxicity, etc. Thus, there is need to target these issues and improve current treatment options...
August 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Zuzana Vancova, Martina Cizmarikova, Jozef Dragasek, Silvia Zofcakova, Peter Kolarcik, Jan Mojzis
BACKGROUND The role of multidrug resistance 1 gene (MDR1 or ABCB1) polymorphism G2677T was studied in relation to paroxetine therapeutic efficacy and its side effects, as well as its association with selected demographic and clinical characteristics of patients with depressive disorder. MATERIAL AND METHODS To evaluate therapeutic efficacy, all patients (n=61) were rated at week 0, 2, 4, and 6 using the Hamilton Rating Scale for Depression (HAMD-21). They were labelled as "responders" (a decrease in HAMD ≥50%) and "nonresponders"...
May 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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