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intestinal obstruction secondary metastasis

Muhammad Wasif Saif, James A Knost, E Gabriela Chiorean, Siva Rama Prasad Kambhampati, Danni Yu, Bronislaw Pytowski, Amy Qin, John S Kauh, Bert H O'Neil
PURPOSE: Metastasis of solid tumors to regional lymph nodes is facilitated by tumor lymphangiogenesis, which is primarily mediated by the vascular endothelial growth factor receptor 3 (VEGFR-3). We conducted a phase 1 dose-escalation (part A) study of the VEGFR-3 human immunoglobulin G subclass 1 monoclonal antibody LY3022856 in advanced solid tumors, followed by a colorectal cancer (CRC) expansion (part B). METHODS: Part A evaluated the safety profile and maximum tolerated dose (MTD) of LY3022856 in patients treated intravenously at doses of 5-30 mg/kg weekly (qwk)...
October 2016: Cancer Chemotherapy and Pharmacology
Dumitru Cristinel Badiu, Cristina Alexandra Manea, Vlad Porojan, Marius Paraschiv, Claudia Mehedintu, Ionut Simion Coman, Valentin Titus Grigorean
Osteosarcomas are the most frequent primary malignant bone tumors in children and adolescents. Like brain metastases in osteosarcomas, the bowel metastases are very rare. We present the case of a 23-year-old female patient, diagnosed and operated in 2008 of osteosarcoma at the tibia, for which she had sessions of neoadjuvant and adjuvant chemotherapy, but presented lungs metastases for which she underwent surgery in 2014. Then, in March 2015, she was diagnosed with an intracranial expansive process, an osteosarcoma metastasis, for which a total ablation of the tumor was performed during the early postoperatory period, being transferred to the General Surgery Clinic for abdominal pain, abdominal distention, vomiting, and lack of intestinal transit regarding faeces and intestinal gas...
May 2016: Chirurgia
Eduardo Moreno-Aguilera, Francisco Iván Galeana-Nogueda, Jesús Vera-Aguilera, Carlos Vera-Aguilera, Luis Alfonso Ley-Marcial
BACKGROUND: The first reported case of intestinal perforation secondary to metastatic lung carcinoma was reported in 1957. Intestinal metastases are present in up to 1.8% of the cases, with small bowel obstruction as the most common clinical presentation. CLINICAL CASE: An 89 year-old male, who was diagnosed with a high-grade pulmonary mucoepidermoid tumour 2 months previously. The patient was admitted to the hospital for 3 days due to diffuse colic abdominal pain of moderate to severe intensity, accompanied by nausea and gastric vomiting, as well as 2 episodes of bloody bowel movements...
May 31, 2016: Cirugia y Cirujanos
Chang Woo Kim, Jeong-Heum Baek, Gyu-Seog Choi, Chang Sik Yu, Sung Bum Kang, Won Cheol Park, Bong Hwa Lee, Hyeong Rok Kim, Jae Hwan Oh, Jae-Hwang Kim, Seung-Yong Jeong, Jung Bae Ahn, Seung Hyuk Baik
BACKGROUND: Approximately 20 % of all patients with colorectal cancer are diagnosed as having Stage IV cancer; 80 % of these present with unresectable metastatic lesions. It is controversial whether chemotherapy with or without primary tumor resection (PTR) is effective for the treatment of patients with colorectal cancer with unresectable metastasis. Primary tumor resection could prevent tumor-related complications such as intestinal obstruction, perforation, bleeding, or fistula. Moreover, it may be associated with an increase in overall survival...
2016: Trials
Andrew James Hotchen, Khimara Naidoo, Sandro Lanzon-Miller
INTRODUCTION: Gastropancreato-neuroendocrine tumours (GETs) are rare, especially when they occur alongside colorectal adenocarcinoma. Furthermore, multiple GETs occurring within the small bowel are less frequent with only two cases described within the literature. PRESENTATION OF CASE: A healthy 58-year old woman presented with severe gastrointestinal pain and faecal incontinence. Family history revealed consanguineous parents and a brother who had recently died of a gastric GET...
September 2014: Annals of Medicine and Surgery
Vincenzo Vigorita, Fabio Ausania, Marco Bertucci Zoccali, Cristina Facal Alvarez, Blanca De Urrutia Nadal, Jose Enrique Casal Nuñez
INTRODUCTION: Primary intestinal melanoma is a rare entity, however the gastrointestinal tract, and particularly the small bowel, is a common site of recurrence from cutaneous melanoma. PRESENTATION OF CASE We report the case of a 48 year old woman with small bowel intussusception secondary to metastatic cutaneous melanoma, 15 years after excision of the primary tumor. The patient underwent an emergency small bowel resection with negative margins on final pathology. DISCUSSION: Surgical resection is a palliative, yet necessary, procedure in the setting of small bowel obstruction due to intussusception secondary to intestinal metastatic melanoma...
2015: International Journal of Surgery Case Reports
Louis Tsun Cheung Chow
The differentiation between osteomyelitis and bone tumor may be difficult due to their overlapping clinical and radiological features. A 25-year-old lady presented with left knee pain and joint effusion associated with redness and hotness. A sub-optimally taken plain radiograph showed mixed osteolytic and osteoblastic lesion in the left lower femur with surrounding soft tissue swelling. Since the clinical diagnosis was acute osteomyelitis and arthritis, arthroscopic lavage was performed as a diagnostic and therapeutic procedure...
December 2014: Pathology, Research and Practice
Ben-Hua Xu, Pan Chi, Jin-Hua Guo, Guo-Xian Guan, Tian-Lan Tang, Ying-Hong Yang, Ming-Qiu Chen, Jian-Yuan Song, Chang-Yin Feng
AIMS AND BACKGROUND: Locally advanced rectal adenocarcinoma is typically treated with neoadjuvant chemoradiotherapy and surgery. We assessed the effect of an additional cycle of capecitabine/oxaliplatin chemotherapy before surgery in 57 patients with T3/4, N+/- or T1/2, N+ rectal cancer. MATERIALS AND STUDY DESIGN: Radiotherapy (total dose, 50.4 Gy) was combined with three cycles of chemotherapy (two cycles concomitant with radiotherapy), and each cycle consisted of oxaliplatin (130 mg/m2 on day 1) and capecitabine (825 mg/m2, twice per day from day 1 to day 14) for 21 days...
March 2014: Tumori
Seiichiro Abe, Ichiro Oda, Koji Inaba, Haruhisa Suzuki, Shigetaka Yoshinaga, Satoru Nonaka, Madoka Morota, Naoya Murakami, Jun Itami, Yukio Kobayashi, Akiko Miyagi Maeshima, Yutaka Saito
BACKGROUND: The favorable response rate of radiotherapy for localized gastric mucosa-associated lymphoid tissue lymphoma refractory to Helicobacter pylori eradication has been demonstrated. However, there are limited data available on the long-term outcomes. The aim of this retrospective study was to evaluate the long-term outcomes of radiotherapy for localized gastric mucosa-associated lymphoid tissue lymphoma refractory to Helicobacter pylori eradication. METHODS: Thirty-four consecutive patients with localized gastric mucosa-associated lymphoid tissue lymphoma that were refractory to eradication were treated with radiotherapy (a total dose of 30 Gy)...
September 2013: Japanese Journal of Clinical Oncology
Yi-Zarn Wang, Heather King, Anne Diebold
OBJECTIVES: Neuroendocrine tumors (NETs) are relatively rare with an indolent nature. As a result, treatment is often delayed and passive. The most commonly recognized disease progression leading to death is from the sequelae of bowel obstruction, ischemia, or liver failure secondary to liver metastasis. We recently recognized a rare cocoon-like formation in patients with metastatic gastroenteropancreatic NETs and hypothesize that this may be a distinct, final pathway for these patients...
August 2013: Pancreas
Charles Sabbagh, Denis Chatelain, Nathalie Trouillet, François Mauvais, Sif Bendjaballah, François Browet, Jean-Marc Regimbeau
BACKGROUND: In a recent propensity score study, we established that overall- and disease-free survival were worse after use of a colonic stent (CS) than after emergency surgery for colonic obstruction. The present study sought to explain the association between CS use and poor survival by analyzing pathological specimens. METHODS: From January 1998 to December 2011, all patients with left obstructive colon cancer and having been operated on with curative intent were included in the study...
October 2013: Surgical Endoscopy
Laurence E McCahill, Greg Yothers, Saima Sharif, Nicholas J Petrelli, Lily Lau Lai, Naftali Bechar, Jeffrey K Giguere, Shaker R Dakhil, Louis Fehrenbacher, Samia H Lopa, Lawrence D Wagman, Michael J O'Connell, Norman Wolmark
PURPOSE: Major concerns surround combining chemotherapy with bevacizumab in patients with colon cancer presenting with an asymptomatic intact primary tumor (IPT) and synchronous yet unresectable metastatic disease. Surgical resection of asymptomatic IPT is controversial. PATIENTS AND METHODS: Eligibility for this prospective, multicenter phase II trial included Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1, asymptomatic IPT, and unresectable metastases...
September 10, 2012: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Fernando A Alvarez, Matías Nicolás, Jeremías Goransky, Carlos A Vaccaro, Axel Beskow, Demetrio Cavadas
The small intestine is a frequent site of melanoma metastases and the most common cause of secondary intestinal tumors. Even though, its presentation with intestinal obstruction due to intussusception is very rare. We present a 47-year-old woman with a medical history of facial melanoma operated 17 years ago and recently diagnosed of cervical recurrence who complained of abdominal pain of one week duration accompanied with vomiting and abdominal distension. Computed tomography (CT) scan revealed marked distension of the small intestine with features suggesting intussusception of the distal ileum...
2011: International Journal of Surgery Case Reports
Martin B Niederle, Bruno Niederle
BACKGROUND: The aim of this prospectively collected, retrospectively analyzed clinical investigation was to describe "unmasked" clinical symptoms and methods of diagnosis, treatment, and short-term follow-up of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) diagnosed during 1 year in Austria. METHODS: In total, 277 patients with GEP-NETs were documented. All tumors were immunhistochemically defined according to recently summarized criteria (World Health Organization, European Neuroendocrine Tumour Society)...
2011: Oncologist
Hsin-Chung Lin, Cheng-Ping Yu, Hsin-An Lin, Herng-Sheng Lee
Metastasis from lung cancer, often found in the adrenal glands, bone, liver, brain, and kidneys, have been thought to be rare in the digestive system. When a metastatic tumor is found in the intestine, it is most commonly metastatic melanoma or carcinoma of the cervix uteri, ovary, or breast. Yet, intestinal metastases have been described in 11% of lung cancers at autopsy. These metastases may induce gastrointestinal perforation, obstruction, or bleeding. Patients with bleeding from small intestinal metastases secondary to lung cancer almost uniformly have poor prognoses...
May 2011: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Enver Ihtiyar, Ozgül Paşaoğlu, Serdar Erkasap, Barış R Karakaş, Fatih N Yaşar
Goblet cell carcinoid of the large intestine is a rare neoplasm, usually located in ascending colon and rectum. A 60-year-old male patient underwent surgery after the diagnosis of acute abdomen. Exploratory laparotomy revealed perforation with a diameter of 1 cm at the site of the previously performed gastroenterostomy and dilatation of the right colic flexure, secondary to a solid obstructive mass located in the mid-portion of transverse colon. Histopathological investigation of the biopsies, taken from the gastroenterostomy site and the tumor, revealed mixed carcinoid-adenocarcinoma with carcinoid component, predominantly composed of goblet cells...
2010: World Journal of Surgical Oncology
Aydın Aktaş, Gültekin Hoş, Serdar Topaloğlu, Adnan Calık, Abdülkadir Reis, Burhan Pişkin
We herein report a case of ileal invagination secondary to metastasis of a cutaneous melanoma. A 45-year-old female was admitted with intermittent abdominal pain and nausea. The patient's medical history was remarkable for cutaneous malignant melanoma. Imaging studies showed a solid mass in the right lower quadrant and the possibility of invagination. We made a preoperative diagnosis of partial intestinal obstruction, and laparotomy was performed. Intraoperative findings revealed ileal invagination. Segmental ileum resection with wide mesenteric lymph node dissection was performed...
September 2010: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Joshua A Marks, Atul S Rao, David Loren, Agnes Witkiewicz, Michael J Mastrangelo, Adam C Berger
CONTEXT: Malignant melanoma commonly metastasizes to the small intestine where it can cause pain, bleeding, and obstruction. However, jaundice from metastatic melanoma is relatively uncommon. CASE REPORT: A case of known malignant melanoma presenting as new onset obstructive jaundice as a result of a rarely reported metastasis to the ampulla of Vater. CONCLUSION: Multidisciplinary management of patients with metastatic melanoma is essential...
2010: JOP: Journal of the Pancreas
M El Ajmi, R Ksantini, F Chebbi, A Makni, W Rebai, A Daghfous, H Bedioui, F Fteriche, M Jouini, M Kacem, Z Ben Safta
BACKGROUND: Parosteal osteosarcoma is a rare, well-differentiated, predominantly fibro-osseous variant of osteosarcoma. It is regarded as a distinct form of osteosarcoma with better prognosis than conventional osteosarcoma. AIM: We report an unusual case of abdominal mass recurrence of parosteal osteosarcoma of the left distal femur treated eight years previously with wide resection, hip disarticulation and chemotherapy, which presented as an acute abdomen: we discuss the clinical outcomes of this rare entity...
October 2009: Acta Chirurgica Belgica
Yujiro Ito, Koshiro Nishimoto, Kentaro Ogata, Toshio Fujioka
Recurrent urothelial carcinoma of the bladder is often a locally progressive disease. Invasive bladder cancers frequently show lymphatic or hematogenous metastasis. Regional lymph node metastasis is a frequent finding and may be the first sign of recurrence. Rectal involvement and obstruction is rare, but metastasis to the colon, small intestine, and stomach have been reported. Here, we report an unusual case of urothelial carcinoma of the bladder manifesting as an annular rectal obstruction.
August 2008: Hinyokika Kiyo. Acta Urologica Japonica
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