keyword
https://read.qxmd.com/read/26037926/functional-interaction-between-the-scaffold-protein-kidins220-arms-and-neuronal-voltage-gated-na-channels
#21
JOURNAL ARTICLE
Fabrizia Cesca, Annyesha Satapathy, Enrico Ferrea, Thierry Nieus, Fabio Benfenati, Joachim Scholz-Starke
Kidins220 (kinase D-interacting substrate of 220 kDa)/ankyrin repeat-rich membrane spanning (ARMS) acts as a signaling platform at the plasma membrane and is implicated in a multitude of neuronal functions, including the control of neuronal activity. Here, we used the Kidins220(-/-) mouse model to study the effects of Kidins220 ablation on neuronal excitability. Multielectrode array recordings showed reduced evoked spiking activity in Kidins220(-/-) hippocampal networks, which was compatible with the increased excitability of GABAergic neurons determined by current-clamp recordings...
July 17, 2015: Journal of Biological Chemistry
https://read.qxmd.com/read/25636783/investigating-the-role-of-ankyrin-rich-membrane-spanning-protein-in-human-immunodeficiency-virus-type-1-tat-induced-microglia-activation
#22
JOURNAL ARTICLE
Vir B Singh, Alicia K Wooten, Joseph W Jackson, Sanjay B Maggirwar, Michelle Kiebala
Long-term persistence of human immunodeficiency virus type-1 (HIV) in the central nervous system (CNS) results in mild to severe neurocognitive impairment in a significant proportion of the HIV-infected population. These neurological deficits are known as HIV-associated neurocognitive disorders (HAND). Microglia are CNS-resident immune cells that are directly infected by HIV and consequently secrete proinflammatory molecules that contribute to HIV-induced neuroinflammation. Indeed, the number of activated macrophage and microglia in the brain is more highly correlated with cognitive impairment than the amount of neuronal apoptosis...
April 2015: Journal of Neurovirology
https://read.qxmd.com/read/25410904/ankyrin-repeat-rich-membrane-spanning-arms-kidins220-scaffold-protein-regulates-neuroblastoma-cell-proliferation-through-p21
#23
JOURNAL ARTICLE
Heekyung Jung, Joo-Hyun Shin, Young-Seok Park, Mi-Sook Chang
Cell proliferation is tightly controlled by the cell-cycle regulatory proteins, primarily by cyclins and cyclin-dependent kinases (CDKs) in the G1 phase. The ankyrin repeat-rich membrane spanning (ARMS) scaffold protein, also known as kinase D-interacting substrate of 220 kDa (Kidins 220), has been previously identified as a prominent downstream target of neurotrophin and ephrin receptors. Many studies have reported that ARMS/Kidins220 acts as a major signaling platform in organizing the signaling complex to regulate various cellular responses in the nervous and vascular systems...
December 31, 2014: Molecules and Cells
https://read.qxmd.com/read/24649008/blockade-of-ankyrin-repeat-rich-membrane-spanning-protein-modulates-extracellular-signal-regulated-kinase-expression-and-inhibits-allergic-inflammation-in-ovalbumin-sensitized-mice
#24
Xiuqin Ni, Xing Li, Shuhua Tao, Minghui Xu, Hongmei Ma, Xiuli Wang
Ankyrin repeat-rich membrane spanning protein (ARMS), also known as kinase D-interacting substrate of 220 kDa (Kidins220), is a transmembrane protein that has been reported to be involved in the pathogenesis of asthma through the nerve growth factor (NGF)/tyrosine kinase A (TrkA) receptor signaling pathway. To investigate whether NGF/TrkA-Kidins220/ARMS-extracellular signal-regulated kinase (ERK) signaling is activated in airway inflammation of asthma, BALB/c mice were sensitized and challenged with ovalbumin (OVA)...
July 2013: Biomedical Reports
https://read.qxmd.com/read/24307304/kidins220-arms-is-dynamically-expressed-during-xenopus-laevis-development
#25
JOURNAL ARTICLE
Silvia Marracci, Marianna Giannini, Marianna Vitiello, Massimiliano Andreazzoli, Luciana Dente
Kidins220 (Kinase D interacting substrate of 220 kDa)/ARMS (Ankyrin Repeat-rich Membrane Spanning) is a conserved scaffold protein that acts as a downstream substrate for protein kinase D and mediates multiple receptor signalling pathways. Despite the dissecting of the function of this protein in mammals, using both in vitro and in vivo studies, a detailed characterization of its gene expression during early phases of embryogenesis has not been described yet. Here, we have used Xenopus laevis as a vertebrate model system to analyze the gene expression and the protein localization of Kidins220/ARMS...
2013: International Journal of Developmental Biology
https://read.qxmd.com/read/24168199/the-entorhinal-cortex-and-neurotrophin-signaling-in-alzheimer-s-disease-and-other-disorders
#26
REVIEW
Helen E Scharfman, Moses V Chao
A major problem in the field of neurodegeneration is the basis of selective vulnerability of subsets of neurons to disease. In aging, Alzheimer's disease (AD), and other disorders such as temporal lobe epilepsy, the superficial layers of the entorhinal cortex (EC) are an area of selective vulnerability. In AD, it has been suggested that the degeneration of these neurons may play a role in causing the disease because it occurs at an early stage. Therefore, it is important to define the distinctive characteristics of the EC that make this region particularly vulnerable...
2013: Cognitive Neuroscience
https://read.qxmd.com/read/24126542/expression-of-neuronal-protein-kidins220-arms-in-the-spleen-and-peripheral-blood-of-mice-following-airway-allergen-challenge
#27
JOURNAL ARTICLE
Ning Li, Xu Dong, Chang Yang, Yuli Liu, Xiuqin Ni
Nerve growth factor (NGF), combined with the high-affinity tyrosine kinase receptor A (TrkA), has been reported to be involved in the pathogenesis of asthma. Ankyrin-rich membrane spanning/transmembrane substrate of protein kinase D (ARMS/Kidins220), a TrkA‑binding protein, modulates the NGF signaling pathway. The aim of the present study was to investigate the expression of Kidins220/ARMS and the effect NGF has on the protein in the spleen and peripheral blood, following airway allergen challenge in mice...
December 2013: Molecular Medicine Reports
https://read.qxmd.com/read/23999075/kidins220-arms-is-expressed-in-neuroblastoma-tumors-and-stabilizes-neurotrophic-signaling-in-a-human-neuroblastoma-cell-line
#28
JOURNAL ARTICLE
Danny A Rogers, Nina F Schor
BACKGROUND: Neurotrophic signaling is an important factor in the survival of developing neurons, and the expression of neurotrophic receptors correlates with prognosis in neuroblastoma. Kinase D-interacting substrate of 220 kDa (Kidins220) associates with neurotrophic receptors and stabilizes them, but the expression and function of Kidins220 in neuroblastoma are unknown. METHODS: We study Kidins220 expression in human neuroblastoma cell lines and tumor samples by western blotting and microarray analyses...
November 2013: Pediatric Research
https://read.qxmd.com/read/23359496/kidins220-arms-associates-with-b-raf-and-the-tcr-promoting-sustained-erk-signaling-in-t-cells
#29
JOURNAL ARTICLE
Sumit Deswal, Anja Meyer, Gina J Fiala, Anja E Eisenhardt, Lisa C Schmitt, Mogjiborahman Salek, Tilman Brummer, Oreste Acuto, Wolfgang W A Schamel
The activation kinetics of MAPK Erk are critical for T cell development and activation. In particular, sustained Erk signaling is required for T cell activation and effector functions, such as IL-2 production. Although Raf-1 triggers transient Erk activation, B-Raf is implicated in sustained Erk signaling after TCR stimulation. In this study, we show that B-Raf is dephosphorylated on its inhibitory serine 365 upon TCR triggering. However, it is unknown how B-Raf activation is coupled to the TCR. Using mass spectrometry, we identified protein kinase D-interacting substrate of 220 kDa (Kidins220)/ankyrin repeat-rich membrane spanning protein, mammalian target of rapamycin, Rictor, Dock2, and GM130 as novel B-Raf interaction partners...
March 1, 2013: Journal of Immunology
https://read.qxmd.com/read/23333500/kidins220-arms-depletion-is-associated-with-the-neural-to-schwann-like-transition-in-a-human-neuroblastoma-cell-line-model
#30
JOURNAL ARTICLE
Danny A Rogers, Nina F Schor
Peripheral neuroblastic tumors exist as a heterogeneous mixture of neuroblastic (N-type) cells and Schwannian stromal (S-type) cells. These stromal cells not only represent a differentiated and less aggressive fraction of the tumor, but also have properties that can influence the further differentiation of nearby malignant cells. In vitro neuroblastoma cultures exhibit similar heterogeneity with N-type and S-type cells representing the neuroblastic and stromal portions of the tumor, respectively, in behavior, morphology, and molecular expression patterns...
March 10, 2013: Experimental Cell Research
https://read.qxmd.com/read/22699907/ankyrin-repeat-rich-membrane-spanning-protein-kidins220-is-required-for-neurotrophin-and-ephrin-receptor-dependent-dendrite-development
#31
JOURNAL ARTICLE
Yu Chen, Wing-Yu Fu, Jacque P K Ip, Tao Ye, Amy K Y Fu, Moses V Chao, Nancy Y Ip
Dendrites are the primary sites on neurons for receiving and integrating inputs from their presynaptic partners. Defects in dendrite development perturb the formation of neural circuitry and impair information processing in the brain. Extracellular cues are important for shaping the dendritic morphogenesis, but the underlying molecular mechanisms are not well understood. In this study, we examined the role of ARMS (ankyrin repeat-rich membrane spanning protein), also known as Kidins220 (kinase D-interacting substrate of 220 kDa), previously identified as a downstream target of neurotrophin and ephrin receptors, in dendrite development...
June 13, 2012: Journal of Neuroscience
https://read.qxmd.com/read/22609016/kidins220-arms-interacts-with-pdzrn3-a-protein-containing-multiple-binding-domains
#32
JOURNAL ARTICLE
Massimiliano Andreazzoli, Gaia Gestri, Elena Landi, Beatrice D'Orsi, Manuela Barilari, Angela Iervolino, Marianna Vitiello, Stephen W Wilson, Luciana Dente
We report the identification of a novel partner of Kidins220/ARMS (Kinase D-interacting substrate of 220 kDa/Ankyrin Repeat-rich Membrane Spanning) an adaptor of neurotrophin receptors playing crucial roles during neurogenesis. Screening a phage display library of brain cDNA products we found that D. rerio Pdzrn3, a protein containing RING-finger and PDZ-domains, interacts with Kidins220/ARMS through its first PDZ-domain. Both zebrafish proteins share high homology with the corresponding mammalian proteins and both genes are developmentally expressed in neural districts where early neurogenesis occurs...
September 2012: Biochimie
https://read.qxmd.com/read/22563401/kidins220-arms-is-a-novel-modulator-of-short-term-synaptic-plasticity-in-hippocampal-gabaergic-neurons
#33
JOURNAL ARTICLE
Joachim Scholz-Starke, Fabrizia Cesca, Giampietro Schiavo, Fabio Benfenati, Pietro Baldelli
Kidins220 (Kinase D interacting substrate of 220 kDa)/ARMS (Ankyrin Repeat-rich Membrane Spanning) is a scaffold protein highly expressed in the nervous system. Previous work on neurons with altered Kidins220/ARMS expression suggested that this protein plays multiple roles in synaptic function. In this study, we analyzed the effects of Kidins220/ARMS ablation on basal synaptic transmission and on a variety of short-term plasticity paradigms in both excitatory and inhibitory synapses using a recently described Kidins220 full knockout mouse...
2012: PloS One
https://read.qxmd.com/read/22562556/kidins220-arms-as-a-functional-mediator-of-multiple-receptor-signalling-pathways
#34
JOURNAL ARTICLE
Veronika E Neubrand, Fabrizia Cesca, Fabio Benfenati, Giampietro Schiavo
An increasing body of evidence suggests that several membrane receptors--in addition to activating distinct signalling cascades--also engage in substantial crosstalk with each other, thereby adjusting their signalling outcome as a function of specific input information. However, little is known about the molecular mechanisms that control their coordination and integration of downstream signalling. A protein that is likely to have a role in this process is kinase-D-interacting substrate of 220 kDa [Kidins220, also known as ankyrin repeat-rich membrane spanning (ARMS), hereafter referred to as Kidins220/ARMS]...
April 15, 2012: Journal of Cell Science
https://read.qxmd.com/read/22048169/kidins220-arms-is-an-essential-modulator-of-cardiovascular-and-nervous-system-development
#35
JOURNAL ARTICLE
F Cesca, A Yabe, B Spencer-Dene, A Arrigoni, M Al-Qatari, D Henderson, H Phillips, M Koltzenburg, F Benfenati, G Schiavo
The growth factor family of neurotrophins has major roles both inside and outside the nervous system. Here, we report a detailed histological analysis of key phenotypes generated by the ablation of the Kinase D interacting substrate of 220 kDa/Ankyrin repeat-rich membrane spanning (Kidins220/ARMS) protein, a membrane-anchored scaffold for the neurotrophin receptors Trk and p75(NTR). Kidins220 is important for heart development, as shown by the severe defects in the outflow tract and ventricle wall formation displayed by the Kidins220 mutant mice...
November 3, 2011: Cell Death & Disease
https://read.qxmd.com/read/22048155/kidins220-arms-mediates-the-integration-of-the-neurotrophin-and-vegf-pathways-in-the-vascular-and-nervous-systems
#36
JOURNAL ARTICLE
F Cesca, A Yabe, B Spencer-Dene, J Scholz-Starke, L Medrihan, C H Maden, H Gerhardt, I R Orriss, P Baldelli, M Al-Qatari, M Koltzenburg, R H Adams, F Benfenati, G Schiavo
Signaling downstream of receptor tyrosine kinases controls cell differentiation and survival. How signals from different receptors are integrated is, however, still poorly understood. In this work, we have identified Kidins220 (Kinase D interacting substrate of 220 kDa)/ARMS (Ankyrin repeat-rich membrane spanning) as a main player in the modulation of neurotrophin and vascular endothelial growth factor (VEGF) signaling in vivo, and a primary determinant for neuronal and cardiovascular development. Kidins220(-/-) embryos die at late stages of gestation, and show extensive cell death in the central and peripheral nervous systems...
February 2012: Cell Death and Differentiation
https://read.qxmd.com/read/21419124/a-selective-role-for-arms-kidins220-scaffold-protein-in-spatial-memory-and-trophic-support-of-entorhinal-and-frontal-cortical-neurons
#37
JOURNAL ARTICLE
Aine M Duffy, Michael J Schaner, Synphen H Wu, Agnieszka Staniszewski, Asok Kumar, Juan Carlos Arévalo, Ottavio Arancio, Moses V Chao, Helen E Scharfman
Progressive cortical pathology is common to several neurodegenerative and psychiatric disorders. The entorhinal cortex (EC) and frontal cortex (FC) are particularly vulnerable, and neurotrophins have been implicated because they appear to be protective. A downstream signal transducer of neurotrophins, the ankyrin repeat-rich membrane spanning scaffold protein/Kidins 220 (ARMS) is expressed in the cortex, where it could play an important role in trophic support. To test this hypothesis, we evaluated mice with a heterozygous deletion of ARMS (ARMS(+/-) mice)...
June 2011: Experimental Neurology
https://read.qxmd.com/read/21381019/the-neuronal-protein-kidins220-arms-associates-with-icam-3-and-other-uropod-components-and-regulates-t-cell-motility
#38
JOURNAL ARTICLE
Roberto Martín Jean-Mairet, Celia López-Menéndez, Lucía Sánchez-Ruiloba, Sandra Sacristán, María Rodríguez-Martínez, Lorena Riol-Blanco, Paloma Sánchez-Mateos, Francisco Sánchez-Madrid, José Luis Rodríguez-Fernández, Miguel R Campanero, Teresa Iglesias
Kinase D interacting substrate of 220 kDa (Kidins220), also known as ankyrin repeat-rich membrane spanning (ARMS), is a protein that is mainly expressed in brain and neural cells where its function is only starting to be characterized. Here, we show that Kidins220/ARMS is also expressed in T lymphocytes where it is highly concentrated at the uropod of polarized T cells. In this cellular model, Kidins220/ARMS colocalizes with typical uropod T-cell molecules and coimmunoprecipitates with ICAM-3. Furthermore, Kidins220/ARMS associates with raft domains at the uropod and coimmunoprecipitates with caveolin-1, a molecule we show here to be also expressed in T cells...
April 2011: European Journal of Immunology
https://read.qxmd.com/read/20943655/the-ankyrin-repeat-rich-membrane-spanning-arms-kidins220-scaffold-protein-is-regulated-by-activity-dependent-calpain-proteolysis-and-modulates-synaptic-plasticity
#39
JOURNAL ARTICLE
Synphen H Wu, Juan Carlos Arévalo, Veronika E Neubrand, Hong Zhang, Ottavio Arancio, Moses V Chao
The expression of forms of synaptic plasticity, such as the phenomenon of long-term potentiation, requires the activity-dependent regulation of synaptic proteins and synapse composition. Here we show that ARMS (ankyrin repeat-rich membrane spanning protein)/Kidins220, a transmembrane scaffold molecule and BDNF TrkB substrate, is significantly reduced in hippocampal neurons after potassium chloride depolarization. The activity-dependent proteolysis of ARMS/Kidins220 was found to occur through calpain, a calcium-activated protease...
December 24, 2010: Journal of Biological Chemistry
https://read.qxmd.com/read/20936698/regulation-of-inhibitory-neurotransmission-by-the-scaffolding-protein-ankyrin-repeat-rich-membrane-spanning-kinase-d-interacting-substrate-of-220-kda
#40
JOURNAL ARTICLE
Jhon-Jairo Sutachan, Moses V Chao, Ipe Ninan
Scaffolding proteins play a critical role in the proper development and function of neural circuits. In contrast to the case for excitatory circuits, in which the role of several scaffolding proteins has been characterized, less is known about the scaffolding proteins that regulate inhibitory neurotransmission. The ankyrin repeat-rich membrane spanning (ARMS)/kinase D-interacting substrate of 220 kDa (Kidins220) scaffolding protein is expressed during the establishment of γ-aminobutyric acid (GABA) neurotransmission and is highly regulated by activity...
December 2010: Journal of Neuroscience Research
keyword
keyword
87951
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.