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Papillary renal cell

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https://www.readbyqxmd.com/read/29452772/metabolic-and-lipidomic-reprogramming-in-renal-cell-carcinoma-subtypes-reflects-regions-of-tumor-origin
#1
Elke Schaeffeler, Florian Büttner, Anna Reustle, Verena Klumpp, Stefan Winter, Steffen Rausch, Pascale Fisel, Jörg Hennenlotter, Stephan Kruck, Arnulf Stenzl, Judith Wahrheit, Denise Sonntag, Marcus Scharpf, Falko Fend, Abbas Agaimy, Arndt Hartmann, Jens Bedke, Matthias Schwab
BACKGROUND: Renal cell carcinoma (RCC) consists of prognostic distinct subtypes derived from different cells of origin (eg, clear cell RCC [ccRCC], papillary RCC [papRCC], and chromophobe RCC [chRCC]). ccRCC is characterized by lipid accumulation and metabolic alterations, whereas data on metabolic alterations in non-ccRCC are limited. OBJECTIVE: We assessed metabolic alterations and the lipid composition of RCC subtypes and ccRCC-derived metastases. Moreover, we elucidated the potential of metabolites/lipids for subtype classification and identification of therapeutic targets...
February 13, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29429165/-clinicopathologic-features-with-collecting-duct-carcinoma-of-kidney-report-of-10-cases
#2
J X Zhou, X R He, G X Song, Z G Zou, L H Wang, R Hu, H X Li
Objective: To study the pathological features, immunophenotypes, differential diagnoses and prognostic parameters of collecting duct carcinoma of the kidney (CDC). Methods: Clinical imaging, histopathology, immunohistochemistry, and survival data of 10 patients at First Affiliated Hospital of Nanjing Medical University from January 2009 to August 2017 were retrospectively analyzed along with a review of literatures. Results: The clinical symptoms of CDC were not specific, and image examinations showed space-occupying mass lesions...
February 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29423582/a-retrospective-review-of-48-individuals-including-12-families-molecularly-diagnosed-with-hereditary-leiomyomatosis-and-renal-cell-cancer-hlrcc
#3
Priya T Bhola, Cathy Gilpin, Amanda Smith, Gail E Graham
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is caused by autosomal dominant germline mutations in the fumarate hydratase (FH) gene and is characterized by cutaneous leiomyomas, uterine leiomyomas and aggressive renal malignancies. We conducted a retrospective chart review to characterize the patients referred to our Regional Genetics Program for assessment of HLRCC from 2004 to mid-2016. Forty-eight of 69 (69.5%) referred individuals were positive for a pathogenic or likely pathogenic variant in FH; they had an average age of 39...
February 8, 2018: Familial Cancer
https://www.readbyqxmd.com/read/29416756/a-mirna-based-classification-of-renal-cell-carcinoma-subtypes-by-pcr-and-in-situ-hybridization
#4
Ashley Di Meo, Rola Saleeb, Samantha J Wala, Heba W Khella, Qiang Ding, Haiyan Zhai, Kalra Krishan, Adriana Krizova, Manal Gabril, Andrew Evans, Fadi Brimo, Maria D Pasic, Antonio Finelli, Eleftherios P Diamandis, George M Yousef
Renal cell carcinoma (RCC) constitutes an array of morphologically and genetically distinct tumors the most prevalent of which are clear cell, papillary, and chromophobe RCC. Accurate distinction between the typically benign-behaving renal oncocytoma and RCC subtypes is a frequent challenge for pathologists. This is critical for clinical decision making. Subtypes also have different survival outcomes and responses to therapy. We extracted RNA from ninety formalin-fixed paraffin-embedded (FFPE) tissues (27 clear cell, 29 papillary, 19 chromophobe, 4 unclassified RCC and 11 oncocytomas)...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416287/hereditary-leiomyomatosis-and-renal-cell-carcinoma-case-report-and-review-of-the-literature
#5
Ferreira Natália, Oliveira Tiago, Oliveira Pedro, Gaspar Sandro
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare genetic disorder in which the affected individuals tend to develop cutaneous leiomyomas, uterine leiomyomas, and renal cell cancer (RCC). Within the spectrum of this syndromic disease, RCC is the most severe manifestation, occurring at a younger age compared to the sporadic form. Pathological suspicion or diagnosis of HLRCC is critical for appropriate clinical management and genetic counseling of the affected family members. In this study, we report the case of a 27-year-old misdiagnosed carrier of HLRCC phenotype, who presented with a large solitary Type II papillary RCC...
January 2018: Urology Annals
https://www.readbyqxmd.com/read/29414519/fat-status-detection-and-histotypes-differentiation-in-solid-renal-masses-using-dixon-technique
#6
Jun Sun, Zhaoyu Xing, Jie Chen, Tingting Zha, Yunjie Cao, Dachuan Zhang, Dexing Zeng, Wei Xing
PURPOSE: To detect fat status and differentiate histotypes of renal masses by using Dixon technique. MATERIALS AND METHODS: This study included 134 solid renal masses. Signal intensity index (SII) and fat fraction (FF) in different histotypes were compared. RESULTS: Only angiomyolipoma (AML), clear cell renal cell carcinoma (RCC), and papillary RCC were confirmed to contain fat. The FF of 16.8% can effectively differentiate AML from clear cell RCC, so did the SII of 9...
January 30, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29410489/pattern-multiplicity-and-fumarate-hydratase-fh-s-2-succino-cysteine-2sc-staining-but-not-eosinophilic-nucleoli-with-perinucleolar-halos-differentiate-hereditary-leiomyomatosis-and-renal-cell-carcinoma-associated-renal-cell-carcinomas-from-kidney-tumors-without
#7
Marie Muller, Marine Guillaud-Bataille, Julia Salleron, Catherine Genestie, Sophie Deveaux, Abdelhamid Slama, Brigitte Bressac de Paillerets, Stéphane Richard, Patrick R Benusiglio, Sophie Ferlicot
Hereditary leiomyomatosis and renal cell carcinoma syndrome is characterized by an increased risk of agressive renal cell carcinoma, often of type 2 papillary histology, and is caused by FH germline mutations. A prominent eosinophilic macronucleolus with a perinucleolar clear halo is distinctive of hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma according to the 2012 ISUP and 2016 WHO kidney tumor classification. From an immunohistochemistry perspective, tumors are often FH-negative and S-(2-succino)-cysteine (2SC) positive...
February 6, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29401040/imaging-follow-up-of-low-risk-incidental-pancreas-and-kidney-findings-effects-of-patient-age-and-comorbidity-on-projected-life-expectancy
#8
Tiana J Raphel, Davis T Weaver, Lincoln L Berland, Brian R Herts, Alec J Megibow, Amy B Knudsen, Pari V Pandharipande
Purpose To determine the effects of patient age and comorbidity level on life expectancy (LE) benefits associated with imaging follow-up of Bosniak IIF renal cysts and pancreatic side-branch (SB) intraductal papillary mucinous neoplasms (IPMNs). Materials and Methods A decision-analytic Markov model to evaluate LE benefits was developed. Hypothetical cohorts with varied age (60-80 years) and comorbidities (none, mild, moderate, or severe) were evaluated. For each finding, LE projections from two strategies were compared: imaging follow-up and no imaging follow-up...
February 5, 2018: Radiology
https://www.readbyqxmd.com/read/29398265/predicting-oncologic-outcomes-in-renal-cell-carcinoma-after-surgery
#9
Bradley C Leibovich, Christine M Lohse, John C Cheville, Harras B Zaid, Stephen A Boorjian, Igor Frank, R Houston Thompson, William P Parker
BACKGROUND: Predicting oncologic outcomes is important for patient counseling, clinical trial design, and biomarker study testing. OBJECTIVE: To develop prognostic models for progression-free (PFS) and cancer-specific survival (CSS) in patients with clear cell renal cell carcinoma (ccRCC), papillary RCC (papRCC), and chromophobe RCC (chrRCC). DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort review of the Mayo Clinic Nephrectomy registry from 1980 to 2010, for patients with nonmetastatic ccRCC, papRCC, and chrRCC...
February 2, 2018: European Urology
https://www.readbyqxmd.com/read/29390196/diagnostic-performance-and-interreader-agreement-of-a-standardized-mr-imaging-approach-in-the-prediction-of-small-renal-mass-histology
#10
Fernando U Kay, Noah E Canvasser, Yin Xi, Daniella F Pinho, Daniel N Costa, Alberto Diaz de Leon, Gaurav Khatri, John R Leyendecker, Takeshi Yokoo, Aaron H Lay, Nicholas Kavoussi, Ersin Koseoglu, Jeffrey A Cadeddu, Ivan Pedrosa
Purpose To assess the diagnostic performance and interreader agreement of a standardized diagnostic algorithm in determining the histologic type of small (≤4 cm) renal masses (SRMs) with multiparametric magnetic resonance (MR) imaging. Materials and Methods This single-center retrospective HIPAA-compliant institutional review board-approved study included 103 patients with 109 SRMs resected between December 2011 and July 2015. The requirement for informed consent was waived. Presurgical renal MR images were reviewed by seven radiologists with diverse experience...
February 1, 2018: Radiology
https://www.readbyqxmd.com/read/29382453/accuracy-of-kidney-cancer-diagnosis-and-histological-subtype-within-canadian-cancer-registry-data
#11
Jeffrey G Himmelman, Jennifer Merrimen, Kara Matheson, Chris Theriault, Lori A Wood
INTRODUCTION: Provincial/territorial cancer registries (PTCRs) are the mainstay for Canadian population-based cancer statistics. Each jurisdiction captures this data in a population-based registry, including the Nova Scotia Cancer Registry (NSCR). The goal of this study was to describe data from the NSCR regarding renal cell carcinoma (RCC) pathology subtype and method of diagnosis and compare it to the actual pathology reports to determine the accuracy of diagnosis and histological subtype assignment...
September 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29379740/recurrent-papillary-renal-cell-carcinoma-with-concomitant-ipsilateral-upper-urinary-tract-urothelial-carcinoma-and-metachronous-urothelial-carcinoma-of-the-bladder
#12
Pooya Banapour, Kian Asanad, Roger Chan, Viet Q Tran
No abstract text is available yet for this article.
March 2018: Urology Case Reports
https://www.readbyqxmd.com/read/29378660/clinical-activity-of-nivolumab-in-patients-with-non-clear-cell-renal-cell-carcinoma
#13
Vadim S Koshkin, Pedro C Barata, Tian Zhang, Daniel J George, Michael B Atkins, William J Kelly, Nicholas J Vogelzang, Sumanta K Pal, JoAnn Hsu, Leonard J Appleman, Moshe C Ornstein, Timothy Gilligan, Petros Grivas, Jorge A Garcia, Brian I Rini
BACKGROUND: Nivolumab is approved for patients with metastatic renal cell carcinoma (mRCC) refractory to prior antiangiogenic therapy. The clinical activity of nivolumab in patients with non-clear cell RCC subtypes remains unknown as these patients were excluded from the original nivolumab trials. METHODS: Patients from 6 centers in the United States who received at least one dose of nivolumab for non-clear cell mRCC between 12/2015 and 06/2017 were identified. A retrospective analysis including patient characteristics, objective response rate according to RECIST v1...
January 29, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29373116/uncommon-hereditary-gynaecological-tumour-syndromes-pathological-features-in-tumours-that-may-predict-risk-for-a-germline-mutation
#14
REVIEW
Karuna Garg, Anthony N Karnezis, Joseph T Rabban
The most common hereditary gynaecological tumour syndromes are hereditary breast and ovarian cancer syndrome and Lynch syndrome. However, pathologists also may encounter gynaecological tumours in women with rare hereditary syndromes. Many of these tumours exhibit distinctive gross and microscopic features that are associated with a risk for an inherited gene mutation. The sensitivity and specificity of these tumour pathology features for predicting an inherited mutation vary depending on the syndrome. By recognising these tumour features, pathologists may potentially contribute to the diagnosis of an unsuspected syndrome by recommending referral of the patient for formal risk assessment by genetic counselling...
January 17, 2018: Pathology
https://www.readbyqxmd.com/read/29372355/worth-a-second-look-outcomes-of-patients-with-initial-finding-of-regular-renal-tissue-in-ct-guided-renal-tumor-biopsies
#15
M Sadat-Khonsari, M Papayannis, P Schriefer, L Kluth, C Meyer, V Schüttfort, M Regier, M Rink, F Chun, M Fisch, A Becker
INTRODUCTION AND OBJECTIVE: Renal tumor biopsy is recommended for histological diagnosis of radiologically indeterminate renal masses, to select patients with small-renal masses for surveillance approaches, before ablative treatments and to confirm metastatic spread of renal cell cancer (RCC), according to the EAU guidelines. We aimed to determine outcomes of patients with suspicious renal masses with initial finding of regular renal tissue in renal tumor biopsies. METHODS: Retrospective database analysis of 101 patients undergoing CT-guided-, percutaneous renal tumor biopsies in local anesthesia...
January 25, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29371091/risk-based-surveillance-after-surgical-treatment-of-renal-cell-carcinoma
#16
Paolo Capogrosso, Alessandro Larcher, Daniel D Sjoberg, Emily A Vertosick, Francesco Cianflone, Paolo Dell'Oglio, Cristina Carenzi, Andrea Salonia, Andrew J Vickers, Francesco Montorsi, Roberto Bertini, Umberto Capitanio
PURPOSE: To assess the accuracy of the University of California Los Angeles integrated staging system (UISS) in predicting postoperative recurrence of RCC, and to evaluate whether including patient age and tumor histology may improve clinical decision-making. MATERIALS AND METHODS: Analyses were performed for 1,630 patients treated with nephrectomy at a single academic center. The accuracy of the UISS model to predict early (<=12 months) and late (>60 months) recurrence after surgery was compared with a new model that includes patient age and disease histology...
January 22, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29361731/in-vitro-antitumor-activity-of-aloperine-on-human-thyroid-cancer-cells-through-caspase-dependent-apoptosis
#17
Ying-Ray Lee, Shu-Hsin Chen, Ching-Yen Lin, Wen-Ying Chao, Yun-Ping Lim, Hui-I Yu, Chieh-Hsiang Lu
The global incidence of thyroid cancer, one of the most common endocrine malignancies, is especially high among women. Although most patients with thyroid cancers exhibit a good prognosis with standard treatment, there are no effective therapies for patients with anaplastic thyroid cancers or cancers that have reached an advanced or recurrent level. Therefore, it is important to develop highly effective compounds for treating such patients. Aloperine, a natural compound isolated from Sophora alopecuroides, has been reported to possess antioxidant, anti-inflammatory, anti-neuronal injury, anti-renal injury, antitumor, anti-allergic, and antiviral properties...
January 21, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29356723/architectural-patterns-are-a-relevant-morphologic-grading-system-for-clear-cell-renal-cell-carcinoma-prognosis-assessment-comparisons-with-who-isup-grade-and-integrated-staging-systems
#18
Jérôme Verine, Delphine Colin, Mary Nheb, Dominique Prapotnich, Guillaume Ploussard, Xavier Cathelineau, François Desgrandchamps, Pierre Mongiat-Artus, Jean-Paul Feugeas
We developed and validated an architecture-based grading for clear cell renal cell carcinoma (ccRCC) in an observational retrospective cohort study including 506 tumors (principal cohort, n=254; validation cohort, n=252). Study endpoints were disease-free survival (DFS) and cancer-specific survival (CSS). Relationships with outcome were analyzed using Harrell concordance index, time-dependent receiver operating characteristic curve, area under curve, and Cox regression model. An architecture-based grading was devised on positive likelihood ratio (LR+) for DFS at 50 months as follows: grade 1 (LR+<0...
January 19, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29344091/the-correlation-between-gain-of-chromosome-8q-and-survival-in-patients-with-clear-and-papillary-renal-cell-carcinoma
#19
Reza Mehrazin, Essel Dulaimi, Robert G Uzzo, Karthik Devarjan, Jianming Pei, Marc C Smaldone, Alexander Kutikov, Joseph R Testa, Tahseen Al-Saleem
Background: The proto-oncogene c-MYC, located on chromosome 8q, can be upregulated through gain of 8q, causing alteration in biology of renal cell carcinoma (RCC). The aim of this study was to evaluate the prevalence of c-MYC through chromosome 8q gain and to correlate findings with cancer-specific mortality (CSM), and overall survival (OS). Methods: Cytogenetic analysis by conventional or Chromosomal Genomic Microarray Analysis (CMA) was performed on 414 renal tumors...
January 2018: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29343919/papillary-renal-cell-carcinoma-with-abscess-formation-a-report-of-three-cases
#20
Girdhar Singh Bora, Pankaj Panwar, Ravimohan S Mavuduru, Nandita Kakkar
We report three cases of renal cell carcinoma (RCC) associated with abscess formation. Such association has been reported uncommonly in literature. Our cases were unique in that final histopathological report was papillary RCC in all of the patients.
January 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
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