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Gorden Muduma, Isaac Odeyemi, Richard Fulton Pollock
BACKGROUND: As of 2014, there were approximately 8300 patients with a functioning liver transplant in the UK Transplant Registry, with 880 liver transplants performed in 2013-2014 alone. Tacrolimus, typically used in combination with steroids and mycophenolate mofetil, currently represents the cornerstone of post-transplant immunosuppression in liver transplant recipients. OBJECTIVES: The objective of the present study was to evaluate the cost-effectiveness of prolonged-release (PR) tacrolimus (Advagraf(®), Astellas Pharma Inc...
March 2016: Drugs—Real World Outcomes
Suzy Duckworth, Lucy C Chappell, Paul T Seed, Lucy Mackillop, Andrew H Shennan, Rachael Hunter
OBJECTIVE: To model the resource implications of placental growth factor (PlGF) testing in women with suspected pre-eclampsia prior to 35 weeks' gestation as part of a management algorithm, compared with current practice. METHODS: Data on resource use from 132 women with suspected pre-eclampsia prior to 35 weeks' gestation, enrolled in a prospective observational cohort study evaluating PlGF measurement within antenatal assessment units within two UK consultant-led maternity units was extracted by case note review...
2016: PloS One
Ignacio Rodriguez-Una, Augusto Azuara-Blanco, Anthony J King
BACKGROUND: To evaluate the spectrum of glaucoma surgery and the post-operative follow-up regimes undertaken among glaucoma specialists in the United Kingdom. DESIGN: National survey. PARTICIPANTS: Seventy-five glaucoma specialists (consultants and fellows). METHODS: An eight-question survey was emailed to all glaucoma subspecialists members of the United Kingdom and Eire Glaucoma Society. MAIN OUTCOME MEASURES: Surgery undertaken, post-operative management, awareness of intervention tariff and handling of the follow-up burden generated through surgery...
October 11, 2016: Clinical & Experimental Ophthalmology
Maurizio Landolina, Giovanni Morani, Antonio Curnis, Antonello Vado, Antonio D'Onofrio, Valter Bianchi, Giuseppe Stabile, Martino Crosato, Barbara Petracci, Carlo Ceriotti, Luca Bontempi, Martina Morosato, Gian Paolo Ballari, Maurizio Gasparini
AIMS: Patients receiving cardiac resynchronization therapy defibrillators (CRT-Ds) are likely to undergo one or more device replacements, mainly for battery depletion. We assessed the economic impact of battery depletion on the overall cost of CRT-D treatment from the perspectives of the healthcare system and the hospital. We also compared devices of different generations and from different manufacturers in terms of therapy cost. METHODS AND RESULTS: We analysed data on 1792 CRT-Ds implanted in 1399 patients in 9 Italian centres...
October 4, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Yasuo Yanagi, Aya Fukuda, Victor Barzey, Kenji Adachi
OBJECTIVE: This analysis estimated the cost-effectiveness of intravitreal aflibercept injection(s) (IAI) for wet age-related macular degeneration (wAMD) compared with other treatments in Japan. METHODS: This was a cost-utility analysis based on published data. A state-transition cohort model was constructed with six health states based on best-corrected visual acuity in the better-seeing eye. The cycle time was 4 weeks, and the time horizon was 12 years. The model compared IAI 2mg every 8 weeks (2q8) for 2 years after three initial monthly injections, ranibizumab as needed, ranibizumab 0...
October 5, 2016: Journal of Medical Economics
Giuseppe Turchetti, S Bellelli, M Amato, S Bianchi, P Conti, A Cupisti, V Panichi, A Rosati, F Pizzarelli
This study aims to estimate the mean annual social cost per patient with chronic kidney disease (CKD) by stages 4 and 5 pre-dialyses and cost components in Italy. The multicenter cross-sectional study included all adult outpatients in charge of the 14 main Nephrology Centers of Tuscany Region during 7 weeks from 2012 to 2013. Direct medical costs have been estimated using tariffs for laboratory tests, diagnostic exams, visits, hospitalization and prices for drugs. Non-medical costs included expenses of low-protein special foods, travel, and formal and informal care...
October 3, 2016: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
Jean-Pascal Devailly, Laurence Josse
OBJECTIVE: In all countries, the boundaries are ambiguous between acute and post-acute as well as defining the dimensions of care. The aim of this study is to analyze relations between segmentation of care and payment systems. In the new prospective payment system implemented in French SSR, the grouping unit is inpatient stay and the week for day hospitalization. In 1991, the field of SSR mixed structures as diverse in their purposes as public or private hospital units of rehabilitation and "nursing homes"...
September 2016: Annals of Physical and Rehabilitation Medicine
Emily-Ruth Marriott, Guy van Hazel, Peter Gibbs, Anthony J Hatswell
AIMS: The primary aim of this study was to perform a mapping of the EORTC-QLQ-C30 scores to EQ-5D-3L for the SIRFLOX study; a large dataset of patients with previously untreated liver-only or liver-dominant metastatic colorectal cancer (mCRC). A secondary aim was to compare the predictive validity of existing mappings from EORTC-QLQ-C30 to EQ-5D-3L conducted in other cancers. METHODS AND MATERIALS: Questionnaires (completed within 529 patients) were used in a linear mixed regression to model EQ-5D-3L utility values (scored using the UK tariff) as a function of the five function scores, nine symptom scores, and the global score from the EORTC-QLQ-C30 questionnaire...
October 13, 2016: Journal of Medical Economics
Michael B Fisher, Katherine F Shields, Terence U Chan, Elizabeth Christenson, Ryan D Cronk, Hannah Leker, Destina Samani, Patrick Apoya, Alexandra Lutz, Jamie Bartram
Safe drinking water is critical to human health and development. In rural sub-Saharan Africa, most improved water sources are boreholes with handpumps; studies suggest that up to one third of these handpumps are nonfunctional at any given time. This work presents findings from a secondary analysis of cross-sectional data from 1509 water sources in 570 communities in the rural Greater Afram Plains (GAP) region of Ghana; one of the largest studies of its kind. 79.4% of enumerated water sources were functional when visited; in multivariable regressions, functionality depended on source age, management, tariff collection, the number of other sources in the community, and the district...
October 2015: Water Resources Research
Raffaella Niola, Francesco Giurazza, Aleksandra Torbica, Emiliano Schena, Mattia Silvestre, Franco Maglione
Postpartum hemorrhages occur in 5 % of all deliveries. Open surgery and endovascular embolization techniques are the options commonly applied to face this life-threatening scenario. A cost analysis has been performed to compare the standard embolization endovascular approach, performed postpartum in emergency settlement, with a novel proposed preventive embolization approach, and performed in election in selected high-risk patients before the delivery. Two groups have been compared: 46 patients (non-preventive group) and 67 patients (preventive group)...
September 24, 2016: La Radiologia Medica
Anna Trisia Beby, Tom Cornelis, Raymund Zinck, Frank Xiaoqing Liu
INTRODUCTION: In the Netherlands, the current standard of care for treating patients with end-stage renal disease is three sessions of in-center hemodialysis (conventional ICHD). However, the literature indicates that high dose hemodialysis (high dose HD) may provide better health outcome such as survival and quality of life. The objective of this study was to determine the cost-effectiveness of high dose HD, both in-center and at home, in comparison to conventional ICHD from a Dutch payer's perspective over a 5 year period...
September 23, 2016: Advances in Therapy
R Fanous, S Sabharwal, A Altaie, C M Gupte, P Reilly
We present a review evaluating all litigation claims relating to hip fractures made in a 10-year period between 2005 and 2015. Data was obtained from the NHS Litigation Authority through a freedom of information request. All claims relating to hip fractures were reviewed. During the period analysed, 216 claims were made, of which 148 were successful (69%). The total cost of settling these claims was in excess of £5 million. The introduction of a best-practice tariff by the Department of Health in 2010 was designed to improve the quality of care for hip fracture patients...
September 23, 2016: Annals of the Royal College of Surgeons of England
Huong Thanh Vu
This paper by adopting the Software on Market Analysis and Restrictions on Trade assessed the ex-ante impact of tariff elimination under the European-Vietnam free trade agreement (EVFTA) on Vietnam's pharmaceutical imports from the EU based on two scenarios. The results showed that although Vietnam's tariff removal for the EU's medicines would not result in a significant increase in Vietnam's imports from the EU, Vietnam's deeper integration with ASEAN + 3 and TPP (the Trans-Pacific Partnership) nations would affect quite slightly on its imports from the EU...
2016: SpringerPlus
Rana Maroun, Franck Maunoury, Laure Benjamin, Gaëlle Nachbaur, Isabelle Durand-Zaleski
BACKGROUND & OBJECTIVES: The aim of this study was to assess the economic burden of hospitalisations for metastatic renal cell carcinoma (mRCC), to describe the patterns of prescribing expensive drugs and to explore the impact of geographic and socio-demographic factors on the use of these drugs. METHODS: We performed a retrospective analysis from the French national hospitals database. Hospital stays for mRCC between 2008 and 2013 were identified by combining the 10th revision of the International Classification of Diseases (ICD-10) codes for renal cell carcinoma (C64) and codes for metastases (C77 to C79)...
2016: PloS One
Marie Lindkvist, Inna Feldman
BACKGROUND: Many intervention-based studies aiming to improve mental health do not include a multi-attribute utility instrument (MAUI) that produces quality-adjusted life-years (QALYs) and it limits the applicability of the health economic analyses. This study aims to develop 'crosswalk' transformation algorithm between a measure for psychological distress General Health Questionnaire (GHQ-12) and MAUI EuroQoL (EQ-5D-3L). METHODS: The study is based on a survey questionnaire sent to a random sample in four counties in Sweden in 2012...
2016: Health and Quality of Life Outcomes
M I Boikov, V G Butova
Cost price of dental services in system of obligatory medical insurance is higher two fold than officially determined tariffs. Costs of the same services in medical organizations of the same federal region in Russia tend to varyMeasures directed at the stimulation of reduction of expenses connected with the keep of those medical organizations that have increased expenses (compared to other medical organizations) should be considered.
2016: Stomatologii︠a︡
Sukumar Biswas, Wei Fan, Rong Li, Sifan Li, Wenli Ping, Shujun Li, Alexandra Naumova, Tamara Peelen, Esther Kok, Zheng Yuan, Dabing Zhang, Jianxin Shi
Reliable methods are needed to detect the presence of tobacco components in tobacco products to effectively control smuggling and classify tariff and excise in tobacco industry to control illegal tobacco trade. In this study, two sensitive and specific DNA based methods, one quantitative real-time PCR (qPCR) assay and the other loop-mediated isothermal amplification (LAMP) assay, were developed for the reliable and efficient detection of the presence of tobacco (Nicotiana tabacum) in various tobacco samples and commodities...
2016: International Journal of Analytical Chemistry
Shuli Brammli-Greenberg, Ruth Waitzberg, Vadim Perman, Ronni Gamzu
Historically, Israel paid its non-profit hospitals on a perdiem (PD) basis. Recently, like other OECD countries, Israel has moved to activity-based payments. While most countries have adopted a diagnostic related group (DRG) payment system, Israel has chosen a Procedure-Related Group (PRG) system. This differs from the DRG system because it classifies patients by procedure rather than diagnosis. In Israel, the PRG system was found to be more feasible given the lack of data and information needed in the DRG classification system...
September 1, 2016: Health Policy
Renato P Ricci, Alfredo Vicentini, Antonio D'Onofrio, Antonio Sagone, Giovanni Rovaris, Luigi Padeletti, Loredana Morichelli, Antonio Fusco, Stefano De Vivo, Leonida Lombardi, Alessandra Denaro, Annalisa Pollastrelli, Irene Colangelo, Massimo Santini
BACKGROUND: Remote monitoring (RM) of cardiac implantable electronic devices has been demonstrated to improve outpatient clinic workflow and patient management. However, few data are available on the socioeconomic impact of RM. OBJECTIVE: The aim of this study was to assess the costs and benefits of RM compared with standard care (SC). METHODS: We used 12-month patient data from the Health Economics Evaluation Registry for Remote Follow-up (TARIFF) study (N = 209; RM: n = 102; SC: n = 107)...
September 8, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Yi Zhao, Rohina Joshi, Rasika Rampatige, Jixin Sun, Liping Huang, Shu Chen, Ruijun Wu, Bruce Neal, Alan D Lopez, Andrea L Stewart, Peter T Serina, Cong Li, Jing Zhang, Jianxin Zhang, Yuhong Zhang, Lijing L Yan
Traditionally, verbal autopsies (VA) are collected on paper-based questionnaires and reviewed by physicians for cause of death assignment, it is resource intensive and time consuming. The Population Health Metrics Research Consortium VA questionnaires was made available on an Android-based application and cause of death was derived using the Tariff method. Over one year, all adult deaths occurring in 48 villages in 4 counties were identified and a VA interview was conducted using the smartphone VA application...
September 8, 2016: Asia-Pacific Journal of Public Health
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