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https://www.readbyqxmd.com/read/29234758/polymorphism-of-griseofulvin-concomitant-crystallization-from-the-melt-and-a-single-crystal-structure-of-a-metastable-polymorph-with-anomalously-large-thermal-expansion
#1
Yuan Su, Jia Xu, Qin Shi, Lian Yu, Ting Cai
Griseofulvin (GSF) is a classic antifungal drug that has been in clinical use for over 50 years, but its polymorphism was recognized only recently via melt crystallization. Here we report the structure of a single crystal of GSF form II which was unusually harvested from the supercooled melt. GSF form II exhibits an anomalously large thermal expansion coefficient.
December 13, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29232689/a-computational-model-for-regulation-of-nanoscale-glucan-exposure-in-candida-albicans
#2
Michael J Wester, Jia Lin, Aaron K Neumann
Candida albicans is a virulent human opportunistic pathogen. It evades innate immune surveillance by masking an immunogenic cell wall polysaccharide, β-glucan, from recognition by the immunoreceptor Dectin-1. Glucan unmasking by the antifungal drug caspofungin leads to changes in the nanostructure of glucan exposure accessible to Dectin-1. The physical mechanism that regulates glucan exposure is poorly understood, but it controls the nanobiology of fungal pathogen recognition. We created computational models to simulate hypothetical physical processes of unmasking glucan in a biologically realistic distribution of cell wall glucan fibrils...
2017: PloS One
https://www.readbyqxmd.com/read/29230923/primary-antifungal-prophylaxis-decrease-of-invasive-fungal-disease-incidence-and-reduction-of-risk-factors-in-hematological-patients-in-a-5-year-retrospective-study
#3
Yan Li, Mingjuan Liu, Bing Zhai, Xiaoli Zhao, Lijun Wang, Honghua Li, Shuhong Wang, Haiyan Zhu, Quanshun Wang, Chunji Gao, Wenrong Huang, Li Yu
BACKGROUND: Invasive fungal disease (IFD) is a major cause of morbidity and mortality in patients with hematological malignancies. AIM: To evaluate the efficacy and rationality of primary antifungal prophylaxis (PAP) in a 5-year real life setting and choose an appropriate PAP strategy. METHODS: Clinical data of patients were retrospectively reviewed and IFD was diagnosed using the revised diagnostic criteria. The efficacy of PAP and the risk factors for IFD, especially the rationality of PAP, were evaluated...
December 12, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29228870/augmented-photocatalytic-antibacterial-and-antifungal-activity-of-prunosynthetic-silver-nanoparticles
#4
Shaan Bibi Jaffri, Khuram Shahzad Ahmad
The present study has demystified the first and single step prunosynthesis of the spherical silver nanoparticles (AgNPs) from aqueous fruit extract of angiospermic plant, Prunus cerasifera, which has remarkable fusion of reducing cum stabilizing bioactive components (phenols, anthocyanins, carotenoids, flavonoids, organic acids, tannins and vitamins). Highly stable prunosynthetic AgNPs with 2.04 nm average crystallite size were synthesized in dark and in sunlight at optimized condition of temperature, time and P...
December 11, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29227917/design-synthesis-molecular-docking-of-new-lipophilic-acetamide-derivatives-affording-potential-anticancer-and-antimicrobial-agents
#5
Hany E A Ahmed, Saleh K Ihmaid, Abdelsattar M Omar, Ahmed M Shehata, Heba S Rateb, Mohammed F Zayed, Sahar Ahmed, Mahmoud M Elaasser
Fifteen new substituted N-2-(2-oxo-3-phenylquinoxalin-1(2H)-yl) acetamides 5a-f, 6a-f, and 8a-c were synthesized by reacting ethyl 2-(2-oxo-3-phenylquinoxalin-1(2H)-yl)acetate with various primary amines including benzylamines, sulfonamides, and amino acids. The in vitro antimicrobial screening of the target compounds was screened to assess their antibacterial and antifungal activity. As a result, seven compounds namely; 5a, 5c, 5d, 6a, 6c, 8b and 8c showed a promising broad spectrum antibacterial activity against both Gram-positive and Gram-negative strains...
December 2, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29227694/pulsed-electric-field-assisted-sensitization-of-multidrug-resistant-candida-albicans-to-antifungal-drugs
#6
Vitalij Novickij, Jurgita Švedienė, Algimantas Paškevičius, Svetlana Markovskaja, Irutė Girkontaitė, Auksė Zinkevičienė, Eglė Lastauskienė, Jurij Novickij
AIM: Determine the influence of pH on the inactivation efficiency of C. albicans in pulsed electric fields (PEF) and evaluate the possibilities for sensitization of a drug-resistant strain to antifungal drugs. MATERIALS & METHODS: The effects of PEF (2.5-25 kVcm-1) with fluconazole, terbinafine and naftifine were analyzed at a pH range of 3.0-9.0. Membrane permeabilization was determined by flow cytometry and propidium iodide. RESULTS: PEF induced higher inactivation of C...
December 11, 2017: Future Microbiology
https://www.readbyqxmd.com/read/29227574/light-treatments-of-nail-fungal-infections
#7
REVIEW
Jessica Houang, Gabriel Perrone, Damia Mawad, Philip C Boughton, Andrew J Ruys, Antonio Lauto
Nail fungal infections are notoriously persistent and difficult to treat which can lead to severe health impacts, particularly in the immunocompromised. Current antifungal treatments, including systemic and topical drugs, are prolonged and do not effectively provide a complete cure. Severe side effects are also associated with systemic antifungals, such as hepatoxicity. Light treatments of onychomycosis are an emerging therapy that has localised photodynamic, photothermal or photoablative action. These treatments have shown to be an effective alternative to traditional antifungal remedy with comparable or better cure rates achieved in shorter times and without systemic side effects...
December 11, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29227471/inhibiting-mitochondrial-phosphate-transport-as-an-unexploited-antifungal-strategy
#8
Catherine A McLellan, Benjamin M Vincent, Norma V Solis, Alex K Lancaster, Lucas B Sullivan, Cathy L Hartland, Willmen Youngsaye, Scott G Filler, Luke Whitesell, Susan Lindquist
The development of effective antifungal therapeutics remains a formidable challenge because of the close evolutionary relationship between humans and fungi. Mitochondrial function may present an exploitable vulnerability because of its differential utilization in fungi and its pivotal roles in fungal morphogenesis, virulence, and drug resistance already demonstrated by others. We now report mechanistic characterization of ML316, a thiohydantoin that kills drug-resistant Candida species at nanomolar concentrations through fungal-selective inhibition of the mitochondrial phosphate carrier Mir1...
December 11, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/29226215/in-vitro-antifungal-activity-of-hexahydropyrimidine-derivatives-against-the-causative-agents-of-dermatomycosis
#9
Francislene J Martins, César A Caneschi, Mônica P Senra, Gustavo S G Carvalho, Adilson D da Silva, Nádia R B Raposo
Nitrogenated heterocyclic compounds are present in both natural and synthetic drugs, and hexahydropyrimidine derivatives may prove to be efficient in treating dermatomycosis causing fungi. This study evaluated the antifungal activity of four hexahydropyrimidine derivatives against the dermatomycosis causing fungi. These derivatives were synthesized, characterized, and assessed in terms of their activity against Trichophyton mentagrophytes, Microsporum canis, Microsporum gypseum, Trichophyton rubrum, Fusarium oxysporum, and Epidermophyton floccosum between concentrations 7...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/29223801/the-external-face-of-candida-albicans-a-proteomic-view-of-the-cell-surface-and-the-extracellular-environment
#10
Ana Gil-Bona, Ahinara Amador-García, Concha Gil, Lucia Monteoliva
The cell surface and secreted proteins are the initial points of contact between Candida albicans and the host. Improvements in protein extraction approaches and mass spectrometers have allowed researchers to obtain a comprehensive knowledge of these external subproteomes. In this paper, we review the published proteomic studies that have examined C. albicans extracellular proteins, including the cell surface proteins or surfome and the secreted proteins or secretome. The use of different approaches to isolate cell wall and cell surface proteins, such as fractionation approaches or cell shaving, have resulted in different outcomes...
December 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29223551/recent-advances-in-delivery-of-antifungal-agents-for-therapeutic-management-of-candidiasis
#11
REVIEW
Bhakti Sawant, Tabassum Khan
Candidiasis is a fungal infection caused by yeasts that belong to the genus Candida. There are over twenty species of Candida yeasts that can cause infection in humans, the most common of which is Candida albicans. Candida yeasts normally reside in the intestinal tract and can be found on mucous membranes and skin without causing infection; however, overgrowth of these organisms can cause symptoms to develop. Presence of other diseases that compromises the patient's immunity makes it more difficult to treat...
December 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29223452/antimicrobial-activity-of-bulbothrix-setschwanensis-zahlbr-hale-lichen-by-cell-wall-disruption-of-staphylococcus-aureus-and-cryptococcus-neoformans
#12
Indresh K Maurya, Samer Singh, Rupinder Tewari, Manish Tripathi, Shashi Upadhyay, Yogesh Joshi
In the present study, antimicrobial activity of a common Himalayan lichen viz. Bulbothrix setschwanensis (Zahlbr.) Hale extract in three common solvents (acetone, chloroform and methanol) was evaluated against six bacterial and seven fungal clinical strains. The acetone extract showed promising antimicrobial activity against S. aureus (1.56 mg/mL) and C. neoformans (6.25 mg/mL). Further, GC-MS analysis revealed 2,3-bis(2-methylpentanoyloxy)propyl 2-methylpentanoate and Ethyl 2-[(2R,3R,4aR,8aS)-3-hydroxy-2,3,4,4a,6,7,8,8a-octahydropyrano [3,2-b]pyran-2-yl]acetate as the predominant compounds...
December 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29222709/successful-treatment-of-canine-sporotrichosis-with-terbinafine-case-reports-and-literature-review
#13
Paula Gonçalves Viana, Anna Barreto Fernandes Figueiredo, Isabella Dib Ferreira Gremião, Luisa Helena Monteiro de Miranda, Isabela Maria da Silva Antonio, Jéssica Sepulveda Boechat, Ana Caroline de Sá Machado, Manoel Marques Evangelista de Oliveira, Sandro Antonio Pereira
Sporotrichosis occurs worldwide, and the metropolitan region of Rio de Janeiro, Brazil, is a main endemic area, with a large number of human and animal cases in the last 19 years. This mycosis is more frequently described in cats rather than in dogs. There are a limited number of oral antifungal agents for the treatment of sporotrichosis in animals. In this context, the effectiveness of terbinafine in the treatment of sporotrichosis in humans, as well as the promising results of in vitro susceptibility tests, inspired us to use this drug in the therapy of this mycosis in dogs...
December 8, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29221882/effective-inhibition-of-cbf-14-against-cryptococcus-neoformans-infection-in-mice-and-its-related-anti-inflammatory-activity
#14
Changzhong Yu, Shanshan Wei, Xiaorong Han, Hanhan Liu, Mengxiao Wang, Meiling Jiang, Min Guo, Jie Dou, Changlin Zhou, Lingman Ma
Cbf-14 (RLLRKFFRKLKKSV), a designed peptide derived from cathelicidin family AMP, has proven to be potent against drug-resistant bacteria. In the present study, we investigated the anti-cryptococcal activity of Cbf-14 in vitro and in a pulmonary infection mouse model. Sensitivity test indicated that Cbf-14 possessed effective antifungal activity against Cryptococcus neoformans with an MIC of 4-16 µg/ml, and killing experiments showed that fungicidal activity was achieved after only 4 h treatment with Cbf-14 at 4× MIC concentrations in vitro...
December 5, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/29221859/photodynamic-antimicrobial-chemotherapy-pact-using-toluidine-blue-o-inhibits-the-viability-of-biofilm-produced-by-candida-albicans-at-different-stages-of-development
#15
Ana Paula Pinto, Isabela Bueno Rosseti, Moisés Lopes Carvalho, Bruna Graziele Marques da Silva, Carlos Alberto-Silva, Maricilia Silva Costa
BACKGROUND: Candida albicans is an opportunistic fungus producing both superficial and systemic infections, especially in immunocompromised individuals. It has been demonstrated that C. albicans ability to form biofilms is a crucial process for colonization and virulence. Furthermore, a correlation between the development of drug resistance and biofilm maturation at Candida biofilms has been shown. Photodynamic Antimicrobial Chemotherapy (PACT) is a potential antimicrobial therapy that combines visible light and a non-toxic dye, known as a photosensitizer, producing reactive oxygen species (ROS) that can kill the treated cells...
December 5, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29219892/toxicity-of-vincristine-combined-with-posaconazole-in-children-with-acute-lymphoblastic-leukemia
#16
Esra Pekpak, Talia İleri, Elif İnce, Mehmet Ertem, Zümrüt Uysal
BACKGROUND: Vincristine (VCR) is one of the main drugs of acute lymphoblastic leukemia (ALL) treatment. Azole antifungal medications are used for treatment or prophylaxis of invasive fungal infections in acute leukemia. Coadministration of these drugs increases the risk of VCR toxicity. OBSERVATIONS: We presented a girl with ALL using posaconazole prophylaxis. She developed VCR toxicity that included tubulopathy, high blood pressure, neuropathic pain, difficulty walking, diffuse muscular weakness, constipation, abdominal pain...
December 6, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29218389/primary-prophylaxis-of-invasive-fungal-infections-in-patients-with-haematological-malignancies-2017-update-of-the-recommendations-of-the-infectious-diseases-working-party-agiho-of-the-german-society-for-haematology-and-medical-oncology-dgho
#17
REVIEW
Sibylle C Mellinghoff, Jens Panse, Nael Alakel, Gerhard Behre, Dieter Buchheidt, Maximilian Christopeit, Justin Hasenkamp, Michael Kiehl, Michael Koldehoff, Stefan W Krause, Nicola Lehners, Marie von Lilienfeld-Toal, Annika Y Löhnert, Georg Maschmeyer, Daniel Teschner, Andrew J Ullmann, Olaf Penack, Markus Ruhnke, Karin Mayer, Helmut Ostermann, Hans-H Wolf, Oliver A Cornely
Immunocompromised patients are at high risk of invasive fungal infections (IFI), in particular those with haematological malignancies undergoing remission-induction chemotherapy for acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) and recipients of allogeneic haematopoietic stem cell transplants (HSCT). Despite the development of new treatment options in the past decades, IFI remains a concern due to substantial morbidity and mortality in these patient populations. In addition, the increasing use of new immune modulating drugs in cancer therapy has opened an entirely new spectrum of at risk periods...
December 7, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29217144/histatin-5-induces-the-reversal-of-pdr5p-mediated-fluconazole-resistance-in-saccharomyces%C3%A2-cerevisae
#18
J A da Rocha Curvelo, L F Reis de Sá, D C Clemente de Moraes, R M Soares, A Ferreira-Pereira
BACKGROUND: Candidiasis is a major opportunistic fungal infection in humans. The low number of antifungal drugs available to treat Candida infections and the increasing incidence of multidrug resistant (MDR) strains point to an urgent need of identifying new therapeutic options. The role of salivary components can provide insights for the development of new methodologies of control. OBJECTIVE: The aim of this study was to evaluate the ability of histatin-5, a constitutive immunological peptide present in saliva, in reversing fungal MDR phenotype, using a resistant Saccharomyces cerevisiae strain as model of study...
December 4, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29214974/insights-into-the-candidacidal-mechanism-of-ctn-15-34-a-carboxyl-terminal-crotalicidin-derived-peptide-related-to-cathelicidins
#19
Carolina Sidrim P Cavalcante, Francisca Lidiane Linhares de Aguiar, Raquel O S Fontenelle, Ramon Roseo de P P B de Menezes, Alice Maria Costa Martins, Cláudio B Falcão, David Andreu, Gandhi Rádis-Baptista
PURPOSE: Ctn[15-34], a carboxyl-terminal fragment of crotalicidin (a cathelicidin from the venom gland of a South American rattlesnake), has shown antifungal activity against clinical and standard strains of Candida species. The aim of the present work was to investigate the underlying mechanisms of the candidicidal activity of Ctn[15-34]. METHODOLOGY: The time-kill profile and drug synergism were evaluated by means of a microdilution assay and multi-parametric flow cytometry...
December 7, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29212705/update-from-a-twelve-year-nationwide-fungaemia-surveillance-increasing-intrinsic-and-acquired-resistance-causes-concern
#20
K M T Astvad, H K Johansen, B L Røder, F S Rosenvinge, J D Knudsen, L Lemming, H C Schønheyder, R K Hare, L Kristensen, L Nielsen, J B Gertsen, E Dzajic, M Pedersen, C Østergård, B Olesen, T S Søndergaard, M C Arendrup
New data from the Danish National Fungaemia Surveillance 2012-15 is reported and epidemiological trends are investigated in a 12-year perspective (2004-15). During 2012-15, 1900 out of 1939 (98%) fungal bloodstream isolates were included. The average incidence was 8.4/100,000 inhabitants and this appears to be stabilizing after the increase to 10.1/100,000 in 2011. The incidence was higher in males than females (10.0 vs 6.8) and in patients above 50 years, mainly driven by an increasing incidence among 80-89 years old males (65...
December 6, 2017: Journal of Clinical Microbiology
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