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https://www.readbyqxmd.com/read/29452960/traditionally-practiced-medicinal-plant-extracts-inhibit-the-ergosterol-biosynthesis-of-clinically-isolated-dermatophytic-pathogens
#1
M Chellappandian, M Saravanan, P Pandikumar, P Harikrishnan, K Thirugnanasambantham, S Subramanian, V I Hairul-Islam, S Ignacimuthu
OBJECTIVE: Dermatophytes are resistant to some available antibiotics. Development of new plant drugs to control drug resistant microbes is urgently needed. This study evaluates the antidermatophytic potential of 18 selected medicinal plants used by traditional healers in Theni and Virudhunagar Districts of Tamil Nadu, India. MATERIALS AND METHODS: Selected plant parts were collected, shade dried and powdered. Plant powders were extracted with ethanol and their antifungal potency was investigated against and clinical dermatophytes...
February 13, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29452247/persistent-candidemia-despite-appropriate-fungal-therapy-first-case-of-candida-auris-from-the-united-arab-emirates
#2
Adnan Alatoom, Mohammad Sartawi, Karen Lawlor, Laila AbdelWareth, Jens Thomsen, Ahmad Nusair, Imran Mirza
In this case, we report an elderly patient with multiple chronic conditions and prolonged intensive care units (ICU) stay who had recurrent Candida auris (C. auris) in blood despite antifungal therapy. C. auris was misidentified using conventional automated identification system as Candida haemulonii resulting in delayed diagnosis. The isolate showed increasing minimum inhibitory concentrations (MICs) to different antifungal drugs and persisted in the patient's blood before the patient deceased. This is the first case of C...
February 13, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29446234/a-natural-antioxidant-tannic-acid-mitigates-iron-overload-induced-hepatotoxicity-in-swiss-albino-mice-through-ros-regulation
#3
Tapasree Basu, Sourav Panja, Anil Khushalrao Shendge, Abhishek Das, Nripendranath Mandal
Tannic acid (TA), a water soluble natural polyphenol with 8 gallic acids groups, is abundantly present in various medicinal plants. Previously TA has been investigated for its antimicrobial and antifungal properties. Being a large polyphenol, TA chelates more than 1 metal. Hence TA has been explored for potent antioxidant activities against reactive oxygen species (ROS), reactive nitrogen species (RNS) and as iron chelator in vitro thereby mitigating iron-overload induced hepatotoxicity in vivo. Iron dextran was injected intraperitoneally in Swiss albino mice to induce iron-overload triggered hepatotoxicity, followed by oral administration of TA for remediation...
February 15, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29441986/caspofungin-infusion-solutions-50-mg-100-ml-chemical-stability-and-antifungal-activity-against-candida-spp
#4
N Pinder, L H Pelzl, G Walther, J Backhaus, O Kurzai, T Hoppe-Tichy
BACKGROUND: Ready to use caspofungin infusion bags are centrally prepared in the Hospital Pharmacy, University Hospital of Heidelberg, for economic reasons and possibly occurring problems with drug shortages. The aim of this study was a quality control of the in-house preparation of caspofungin infusion bags and the preparation process. Caspofungin concentration with regard to chemical stability and antifungal activity of caspofungin preparations were defined as quality parameters. METHODS: Three caspofungin infusion bags (50 mg in 100 mL 0...
April 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29434320/host-guest-complexes-of-imazalil-with-cucurbit-8-uril-and-%C3%AE-cyclodextrin-and-their-effect-on-plant-pathogenic-fungi
#5
Naji Al-Dubaili, Khaled El-Tarabily, Na'il Saleh
We report the control of imazalil (IMZ) antifungal activity utilizing its non-covalent assembly with β-cyclodextrins (β-CD) and cucurbit[8]uril (CB8) macrocycles, as well as its stimuli-responsive disassembly with cadaverine. The NMR results are consistent with inclusion of a single IMZ molecule inside the cavities of either CB8 from its aromatic site or β-CD from its aliphatic end. Efficient complex formation with both host molecules and controlled released upon the addition of cadaverine is supported by NMR measurements...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29432912/in-vitro-evaluation-of-new-2-phenoxy-benzo-g-1-2-4-triazolo-1-5-a-quinazoline-derivatives-as-antimicrobial-agents
#6
Hatem A Abuelizz, Rabab A El-Dib, Mohamed Marzouk, Rashad Al-Salahi
Previously, seventeen 2-phenoxy-benzo[g][1,2,4]triazolo[1,5-a]quinazoline derivatives were prepared and characterized by physicochemical and spectral means. This study was conducted to evaluate their activities in vitro against five Gram-negative and five Gram-positive of clinically pathogenic bacterial strains and ten fungal strains. The antimicrobial activity was assessed, and the minimum inhibitory concentration values of the tested compounds were determined in μg ml-1, using the diffusion agar technique...
February 9, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29432386/validation-of-a-reversed-phase-ultra-high-performance-liquid-chromatographic-method-with-photodiode-array-detection-for-the-determination-of-voriconazole-in-human-serum-and-its-application-to-therapeutic-drug-monitoring
#7
Ignacio G Bressán, Mariana L Mendez, María I Gimenez
BACKGROUND: Voriconazole is a broad-spectrum triazole antifungal agent. It is widely used in the treatment of invasive fungal infections in immunocompromised patients. Because the pharmacokinetics of voriconazole demonstrates considerable variability, monitoring its serum levels plays an important role in optimizing therapies against many clinically relevant fungal pathogens. The aim of this study was to validate a simple and rapid U-HPLC-PDA method with minimal sample preparation for routine therapeutic drug monitoring (TDM) of voriconazole...
February 8, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29431860/continuously-infused-amphotericin-b-deoxycholate-for-primary-treatment-of-invasive-fungal-disease-in-acute-myeloid-leukaemia
#8
Christoph Rothenbühler, Ulrike Held, Markus G Manz, Urs Schanz, Bernhard Gerber
Continuous administration of amphotericin B deoxycholate over 24 hours (24 h-D-AmB) is better tolerated than rapid infusions. However, toxicity and outcome have not been assessed in a homogenous patient population with acute myeloid leukaemia (AML). We retrospectively analysed renal function and outcome in all adult patients with AML undergoing intensive chemotherapy between 2007 and 2012 at our institution. We compared a patient group with exposure to 24 h-D-AmB to a patient group without exposure to 24 h-D-AmB...
February 12, 2018: Hematological Oncology
https://www.readbyqxmd.com/read/29427473/antimicrobial-and-cytotoxic-activity-of-silver-nanoparticles-synthesized-from-two-haloalkaliphilic-actinobacterial-strains-alone-and-in-combination-with-antibiotics
#9
Magdalena Wypij, Magdalena Świecimska, Joanna Czarnecka, Hanna Dahm, Mahendra Rai, Patrycja Golinska
AIMS: Presently, the effective antimicrobial agents have been limited by emergence of microbial strains with multi-drug resistance and biofilm formation potential. In the present study, we report remarkable antimicrobial activity of silver nanoparticles (AgNPs) synthesized from Streptomyces calidiresistens IF11 and IF17 strains, including inhibition of biofilm formation and synergistic effect of AgNPs and antibiotics against selected bacteria and yeasts. Cytotoxic effect of AgNPs on mammalian cell lines was also evaluated...
February 10, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29427422/relative-abundance-of-candida-albicans-and-candida-glabrata-in-in-vitro-co-culture-biofilms-impacts-biofilm-structure-and-formation
#10
Michelle L Olson, Arul Jayaraman, Katy C Kao
Candida is a member of the normal human microbiota and often resides on mucosal surfaces such as the oral cavity or the gastrointestinal tract. In addition to their commensality, Candida species can opportunistically become pathogenic if the host microbiota is disrupted or if the host immune system becomes compromised. An important factor for Candida pathogenesis is its ability to form biofilm communities. The two most medically important species - Candida albicans and Candida glabrata - are often co-isolated from infection sites, suggesting the importance of Candida co-culture biofilms...
February 2, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29427394/a-simplified-regimen-of-targeted-antifungal-prophylaxis-in-liver-transplant-recipients-a-single-center-experience
#11
Bruna Lavezzo, Damiano Patrono, Francesco Tandoi, Silvia Martini, Fabrizio Fop, Valentina Ballerini, Chiara Stratta, Stefano Skurzak, Francesco Lupo, Paolo Strignano, Pier Paolo Donadio, Mauro Salizzoni, Renato Romagnoli, Francesco Giuseppe De Rosa
Invasive fungal infection (IFI) is a severe complication of liver transplantation burdened by high mortality. Guidelines recommend targeted rather than universal antifungal prophylaxis based on tiers of risk METHODS: We aimed to evaluate IFI incidence, risk factors and outcome after implementation of a simplified two-tiered targeted prophylaxis regimen based on a single broad-spectrum antifungal drug (amphotericin B). Patients presenting one or more risk factors according to literature were administered prophylaxis...
February 10, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29426804/escmid-study-group-for-infections-in-compromised-hosts-esgich-consensus-document-on-the-safety-of-targeted-and-biologic-therapies-an-infectious-diseases-perspective-cell-surface-receptors-and-associated-signaling-pathways
#12
REVIEW
J Aguilar-Company, M Fernández-Ruiz, R García-Campelo, A C Garrido-Castro, I Ruiz-Camps
BACKGROUND: The present review is part of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Infections in Compromised Hosts (ESGICH) consensus document on the safety of targeted and biologic therapies. AIMS: To review, from an infectious diseases perspective, the safety profile of therapies targeting cell surface receptors and associated signaling pathways among cancer patients and to suggest preventive recommendations...
February 6, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29423632/murine-model-to-follow-hyphal-development-in-invasive-pulmonary-aspergillosis
#13
Zsuzsa M Szigeti, Laszlo Talas, Zoltan Palicz, Peter Szentesi, Zoltan Hargitai, Laszlo Csernoch, Jozsef Balla, Istvan Pocsi, Gaspar Banfalvi, Gabor Szeman-Nagy
Aspergillus fumigatus is an opportunistic pathogen, the leading cause of invasive and disseminated aspergillosis in systemic immunocompromised patients, and an important cause of mortality. The aim of the present study was to adapt a pulmonary aspergillosis murine model, to determine pathodynamical parameters quantitatively, and to follow the progression of fungal infection in vivo. The nasal inoculation of Aspergillus conidia in mice previously subjected to immunosuppression with cyclophosphamide (CP) turned out to be a more suitable model than that of immunosuppressed with hydrocortisone (HC)...
February 8, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29421056/taste-masking-and-rheology-improvement-of-drug-complexed-with-beta-cyclodextrin-and-hydroxypropyl-%C3%AE-cyclodextrin-by-hot-melt-extrusion
#14
Lorena F B Malaquias, Lívia C L Sá-Barreto, Daniel O Freire, Izabel C R Silva, Kapish Karan, Thomas Durig, Eliana M Lima, Ricardo N Marreto, Guilherme M Gelfuso, Tais Gratieri, Marcilio Cunha-Filho
This study aimed to mask fluconazole (FLU) taste and improve its rheological properties by an efficient process of cyclodextrin complexation. For this, hot-melt extrusion (HME) was used to obtain extrudates composed of FLU, hydroxypropylcellulose, and one of two different cyclodextrins (β-cyclodextrin or hydroxypropyl-β-cyclodextrin) maintaining the drug:cyclodextrin molar ratio at 1:0.3 or 1:0.2, respectively. Samples were characterized by physicochemical tests, palatability using e-tongue and antifungal assays...
April 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29420801/in-vitro-effects-of-promethazine-on-cell-morphology-and-structure-and-mitochondrial-activity-of-azole-resistant-candida-tropicalis
#15
Raimunda Sâmia Nogueira Brilhante, Jonathas Sales de Oliveira, Antonio José de Jesus Evangelista, Vandbergue Santos Pereira, Lucas Pereira Alencar, Débora de Souza Collares Maia Castelo-Branco, Lília Maria Carneiro Câmara, Reginaldo Gonçalves de Lima-Neto, Rossana de Aguiar Cordeiro, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
The aim of this study was to evaluate the effect of promethazine on the antifungal minimum inhibitory concentrations against planktonic cells and mature biofilms of Candida tropicalis, as well as investigate its potential mechanisms of cell damage against this yeast species. Three C. tropicalis isolates (two azole-resistant and one azole-susceptible) were evaluated for their planktonic and biofilm susceptibility to promethazine alone and in combination with itraconazole, fluconazole, voriconazole, amphotericin B, and caspofungin...
October 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29420794/itraconazole-in-combination-with-neutrophil-depletion-reduces-the-expression-of-genes-related-to-pulmonary-fibrosis-in-an-experimental-model-of-paracoccidioidomycosis
#16
Juan David Puerta-Arias, Paula Andrea Pino-Tamayo, Julián Camilo Arango, Lina María Salazar-Peláez, Angel González
Itraconazole (ITC) is the drug of choice for treating paracoccidioidomycosis (PCM); nonetheless, patients with the chronic form of this mycosis develop fibrosis, a residual pulmonary abnormality, even after treatment. Recently, we observed that the depletion of neutrophils with a specific monoclonal antibody (mAb-anti-Ly6G) during the chronic stages of PCM was associated with a decrease in the fungal burden, the inflammatory response and a reduction of fibrosis. Herein, we aimed to evaluate the effect of ITC in combination with the mAb-anti-Ly6G in an experimental model of pulmonary PCM...
October 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29420778/deletion-of-aspergillus-nidulans-gdp-mannose-transporters-affects-hyphal-morphometry-cell-wall-architecture-spore-surface-character-cell-adhesion-and-biofilm-formation
#17
Ashraf A Kadry, Amira M El-Ganiny, Rasha A Mosbah, Susan G W Kaminskyj
Systemic human fungal infections are increasingly common. Aspergillus species cause most of the airborne fungal infections. Life-threatening invasive aspergillosis was formerly found only in immune-suppressed patients, but recently some strains of A. fumigatus have become primary pathogens. Many fungal cell wall components are absent from mammalian systems, so they are potential drug targets. Cell-wall-targeting drugs such as echinocandins are used clinically, although echinocandin-resistant strains were discovered shortly after their introduction...
October 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29420763/analysis-of-the-in-vitro-activity-of-human-neutrophils-against-aspergillus-fumigatus-in-presence-of-antifungal-and-immunosuppressive-agents
#18
Christina Decker, Sebastian Wurster, Maria Lazariotou, Anna-Maria Hellmann, Hermann Einsele, Andrew J Ullmann, Jürgen Löffler
Neutrophils are essential in the first line defense against moulds. This in vitro study assessed different neutrophil effector mechanisms in the presence of clinically relevant antifungal and immunosuppressive agents. Therapeutic concentrations of liposomal amphotericin B led to reduced IL-8 and oxidative burst response to the synthetic stimulus PMA, whereas no major alterations of oxidative burst, phagocytosis, or cytokine response to germinated stages of Aspergillus fumigatus and no supra-additive effects of antifungal and immunosuppressive drugs were observed...
October 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29419285/increased-degree-of-unsaturation-in-the-lipid-of-antifungal-cationic-amphiphiles-facilitates-selective-fungal-cell-disruption
#19
Kfir B Steinbuch, Raphael I Benhamou, Lotan Levin, Reuven Stein, Micha Fridman
Antimicrobial cationic amphiphiles derived from aminoglycosides act through cell membrane permeabilization but have limited selectivity for microbial cell membranes. Herein, we report that an increased degree of unsaturation in the fatty acid segment of antifungal cationic amphiphiles derived from the aminoglycoside tobramycin significantly reduced toxicity to mammalian cells. A collection of tobramycin-derived cationic amphiphiles substituted with C18 lipid chains varying in degree of unsaturation and double bond configuration were synthesized...
February 8, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29416360/clinical-characteristics-of-the-first-cases-of-invasive-candidiasis-in-china-due-to-pan-echinocandin-resistant-candida-tropicalis-and-candida-glabrata-isolates-with-delineation-of-their-resistance-mechanisms
#20
Meng Xiao, Xin Fan, Xin Hou, Sharon Ca Chen, He Wang, Fanrong Kong, Zi-Yong Sun, Yun-Zhuo Chu, Ying-Chun Xu
Echinocandin antifungal agents have become the first-line therapy for invasive candidiasis (IC) in many countries. Despite their increasing use, resistance to this class of drug is, overall, still uncommon. Here, we report two patients from the People's Republic of China with IC, one with infection caused by pan-echinocandin-resistant Candida tropicalis and the other by pan-echinocandin-resistant Candida glabrata. We also describe the mechanisms of drug resistance of these isolates. The echinocandin-resistant C...
2018: Infection and Drug Resistance
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