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kisspeptin/GPR54

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https://www.readbyqxmd.com/read/27890710/in-vivo-and-vitro-characterization-of-the-effects-of-kisspeptin-13-endogenous-ligands-for-gpr54-on-mouse-gastrointestinal-motility
#1
Jinhong Jiang, Weidong Jin, Yali Peng, Zhen He, Lijuan Wei, Shu Li, Xiaoli Wang, Min Chang, Rui Wang
Kisspeptin (KP), the endogenous ligand of GPR54, is a mammalian amidated neurohormone, which belongs to the RF-amide peptide family. However, in contrast with the related members of the RF-amide family, little information is available regarding its role in the gastrointestinal motility. With regard to the recent data suggesting KP play an important role in food intake, and while gastrointestinal motility are closely related to it. Thus, in the present work, effects of central administration of KP-13, one of the endogenous active isoforms, on gastrointestinal motility were investigated...
November 25, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27774662/kisspeptin-10-and-the-g-protein-coupled-receptor-54-are-differentially-expressed-in-the-canine-pregnant-uterus-and-trophoblast-cells
#2
S Schäfer-Somi, S S Ay, D Kaya, M Sözmen, H B Beceriklisoy, A R Ağaoğlu, M Fındık, T van Haeften, S Aslan
Uterine tissue was collected from bitches after ovariohysterectomy at different times after ovulation. Samples were assigned to four groups: metestrous non-pregnant, day 10-12, n = 4; pre-implantation, day 10-12, n = 9; post-implantation, day 18-25, n = 13; mid-gestation, day 30-40, n = 7. RT-qPCR detection was performed for kiss1 and the G protein-coupled receptor 54 (GPR54, specific receptor for kisspeptin). In addition, immunohistochemistry was performed for detection of kisspeptin-10 (KP-10), GPR54, as well as pan-cytokeratin and vimentin...
October 23, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27673555/excess-testosterone-exposure-alters-hypothalamic-pituitary-testicular-axis-dynamics-and-gene-expression-in-sheep-fetuses
#3
Charles E Roselli, Rebecka Amodei, Kyle P Gribbin, Keely Corder, Fred Stormshak, Charles T Estill
Prenatal exposure to excess androgen may result in impaired adult fertility in a variety of mammalian species. However, little is known about what feedback mechanisms regulate gonadotropin secretion during early gestation and how they respond to excess T exposure. The objective of this study was to determine the effect of exogenous exposure to T on key genes that regulate gonadotropin and GnRH secretion in fetal male lambs as compared with female cohorts. We found that biweekly maternal testosterone propionate (100 mg) treatment administered from day 30 to day 58 of gestation acutely decreased (P < ...
November 2016: Endocrinology
https://www.readbyqxmd.com/read/27651548/the-role-of-kisspeptin-signalling-in-control-of-reproduction-in-genetically-similar-species
#4
Amir Babiker, Adnan Al Shaikh
Kisspeptin (previously known as metastin) is a protein encoded by the KISS-1 gene in humans. Kisspeptin producing neurons seem to bridge the gap between the sex steroid levels and feedback mechanisms that control the gonadotropin releasing hormone secretion. Since 2003, there are many studies on the facets of neuroendocrine networks that control puberty and fertility. These have explored the role of Kisspeptins in puberty and fertility using animal models. Kisspeptins are universally recognized as essential activators of the gonadotropic axis and they play an essential role in the metabolic regulation of fertility...
2016: Sudanese Journal of Paediatrics
https://www.readbyqxmd.com/read/27616469/kisspeptin-levels-in-idiopathic-hypogonadotropic-hypogonadism-diagnosed-male-patients-and-its-relation-with-glucose-insulin-dynamic
#5
Hasan Öztin, Eylem Çağıltay, Sinan Çağlayan, Mustafa Kaplan, Yaşam Kemal Akpak, Nilay Karaca, Mesut Tığlıoğlu
Male hypogonadism is defined as the deficiency of testosterone or sperm production synthesized by testicles or the deficiency of both. The reasons for hypogonadism may be primary, meaning testicular or secondary, meaning hypothalamohypophyseal. In hypogonadotropic hypogonadism (HH), there is indeficiency in gonadotropic hormones due to hypothalamic or hypophyseal reasons. Gonadotropin-releasing hormone (GnRH) is an important stimulant in releasing follicular stimulant hormone (FSH), mainly luteinizing hormone (LH)...
September 10, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27593959/kisspeptins-estrogens-and-male-fertility
#6
Rosanna Chianese, Gilda Cobellis, Teresa Chioccarelli, Vincenza Ciaramella, Marina Migliaccio, Silvia Fasano, Riccardo Pierantoni, Rosaria Meccariello
BACKGROUND: The control of male fertility requires accurate endocrine, paracrine and autocrine communications along the hypothalamus-pituitary-gonad (HPG) axis. In this respect, the possible interplay between upcoming/classical modulators of reproductive functions deserves attention in that may be a successful tool for the future exploitation of new potential therapeutic targets in the treatment of fertility disorders. METHODS: In this review we will discuss upcoming data concerning the role of kisspeptins, the products of the Kiss1 gene, and estrogens - classically considered as female hormones - as well as their possible interplay in testis...
September 2, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27580229/seasonal-differential-expression-of-kiss-1-gpr54-in-the-striped-hamsters-cricetulus-barabensis-among-different-tissues
#7
Laixiang Xu, Huiliang Xue, Shenning Li, Jinhui Xu, Lei Chen
Kisspeptins and G protein coupled receptor (GPR54) play significant roles in regulating reproductive activity among seasonal reproductive animals; however, the mechanisms of KiSS-1 and GPR54 gene affecting the seasonal reproduction in striped hamster are still unknown. In this study, real-time quantitative PCR was employed to examine the expression profiles of KiSS-1 and GPR54 in the hypothalamus, ovarian, testis, uterus and epididymis of striped hamsters among four different seasons. Our results showed that, among different seasons, the KiSS-1 expression mode of male striped hamster and the GPR54 expression mode of female striped hamster were consistent with the seasonal photoperiod in the hypothalamus...
August 31, 2016: Integrative Zoology
https://www.readbyqxmd.com/read/27519634/prepubertal-exposure-to-an-oestrogenic-mycotoxin-zearalenone-induces-central-precocious-puberty-in-immature-female-rats-through-the-mechanism-of-premature-activation-of-hypothalamic-kisspeptin-gpr54-signaling
#8
Rong Yang, Yi-Mei Wang, Li Zhang, Zeng-Ming Zhao, Jun Zhao, Shuang-Qing Peng
Sporadic epidemics and several researches in rodents indicated that zearalenone (ZEA) and its metabolites, the prevailing oestrogenic mycotoxins in foodstuffs, were a triggering factor for true precocious puberty development in girls. Nevertheless, the neuroendocrine mechanism through which ZEA mycoestrogens advance puberty onset is not fully understood. To elucidate this issue, hypothalamic kisspeptin-G-protein coupled receptor-54 (GPR54) signaling pathway that regulates the onset of puberty was focused on in the present study...
December 5, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27478063/the-roles-of-kisspeptin-revisited-inside-and-outside-the-hypothalamus
#9
Yoshihisa Uenoyama, Vutha Pheng, Hiroko Tsukamura, Kei-Ichiro Maeda
Kisspeptin, encoded by KISS1/Kiss1 gene, is now considered a master regulator of reproductive functions in mammals owing to its involvement in the direct activation of gonadotropin-releasing hormone (GnRH) neurons after binding to its cognate receptor, GPR54. Ever since the discovery of kisspeptin, intensive studies on hypothalamic expression of KISS1/Kiss1 and on physiological roles of hypothalamic kisspeptin neurons have provided clues as to how the brain controls sexual maturation at the onset of puberty and subsequent reproductive performance in mammals...
July 29, 2016: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/27477782/role-of-the-kiss1-kiss1r-system-in-the-regulation-of-pituitary-cell-function
#10
Manuel D Gahete, Mari C Vázquez-Borrego, Antonio J Martínez-Fuentes, Manuel Tena-Sempere, Justo P Castaño, Raúl M Luque
Kisspeptin (Kiss1) is an amidated neurohormone that belongs to the RF-amide peptide family, which has a key role in the control of reproduction. Specifically, kisspeptin regulates reproductive events, including puberty and ovulation, primarily by activating the surface receptor Kiss1r (aka GPR54), at hypothalamic gonadotropin-releasing hormone (GnRH) neurons. More recently, it has been found that kisspeptin peptide is present in the hypophyseal portal circulation and that the Kiss1/Kiss1r system is expressed in pituitary cells, which suggest that kisspeptin could exert an endocrine, paracrine or even autocrine role at the pituitary gland level...
July 29, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27475299/molecular-cloning-of-kisspeptin-receptor-genes-gpr54-1-and-gpr54-2-and-their-expression-profiles-in-the-brain-of-a-tropical-damselfish-during-different-gonadal-stages
#11
Satoshi Imamura, Sung-Pyo Hur, Yuki Takeuchi, Selma Bouchekioua, Akihiro Takemura
The kisspeptin receptor (GPR54) mediates neuroendocrine control of kisspeptin in the brain and acts as a gateway for a pulsatile release of hypothalamic gonadotropin-releasing hormone. This study aimed to clone two GPR54 genes (gpr54-1 and gpr54-2) from the brain of the sapphire devil Chrysiptera cyanea, a tropical damselfish, and to study their involvement in reproduction. The partial sequences of the sapphire devil gpr54-1 cDNA (1059bp) and gpr54-2 cDNA (1098bp) each had an open reading frame encoding a protein of 353 and 366 amino acids, respectively, both of which had structural features of a G-protein-coupled receptor...
July 27, 2016: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/27340201/kisspeptin-across-the-human-lifespan-evidence-from-animal-studies-and-beyond
#12
REVIEW
Sophie A Clarke, Waljit S Dhillo
Since its first description in 1996, the KISS1 gene and its peptide products, kisspeptins, have increasingly become recognised as key regulators of reproductive health. With kisspeptins acting as ligands for the kisspeptin receptor KISS1R (previously known as GPR54 or KPR54), recent work has consistently shown that administration of kisspeptin across a variety of species stimulates gonadotrophin release through influencing gonadotrophin-releasing hormone secretion. Evidence from both animal and human studies supports the finding that kisspeptins are crucial for ensuring healthy development, with knockout animal models, as well as proband genetic testing in human patients affected by abnormal pubertal development, corroborating the notion that a functional kisspeptin receptor is required for appropriate gonadotrophin secretion...
June 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27216535/molecular-identification-of-kiss-gpr54-and-function-analysis-with-mrna-expression-profiles-exposure-to-17%C3%AE-ethinylestradiol-in-rare-minnow-gobiocypris-rarus
#13
Yanping Yang, Jiancao Gao, Cong Yuan, Yingying Zhang, Yongjing Guan, Zaizhao Wang
17α-ethinylestradiol (EE2) is a widely existed endocrine disrupting chemical in water environment. Kisspeptins act as indispensable regulators through GPR54 in the hypothalamic-pituitary-gonadal (HPG) axis. This study aimed to provide further understanding of the effect of EE2 on HPG axis. Molecular cloning and tissue distribution of kiss genes and GPR54s were performed in Gobiocypris rarus. The mRNA expression profiles of kiss1, kiss2, GPR54s and GnRHs were detected in G. rarus brain and/or gonad following 3- and 6-days EE2 (1, 5, 25 and 125 ng/L) exposure...
July 2016: Molecular Biology Reports
https://www.readbyqxmd.com/read/27045655/-effects-of-lipopolysaccharide-and-dexamethasone-on-the-expression-of-kisspeptin-gpr54-in-mouse-hypothalamus
#14
Jiangfeng Mao, Bingkun Huang, Zhao Sun, Qin Han, Min Nie, Xueyan Wu
OBJECTIVE: To evaluate the effects of lipopolysaccharide (LPS) and dexamethasone on function of hypothalamus-pituitary-testis axis and to explore the possible underlying mechanisms. METHODS: LPS (100 μg/kg), dexamethasone (DEX, 1 mg/kg) and phosphate buffer saline (PBS) were injected subcutaneously into castrated mice (n=5 in each group) for 4 weeks. The expression of Kisspeptin and its receptor GPR54 in hypothalamus were measured by immunohistochemistry, and plasma luteinizing hormone (LH) were measured by chemiluminescence immunoassay...
March 22, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27033929/relationships-between-leptin-kiss-1-gpr54-expression-and-tsh-secretion-from-pituitary-cells-of-pubertal-ewes-in-vitro
#15
Paulina Radwańska, Urszula Kosior-Korzecka
Kisspeptin and leptin play a crucial role in the puberty of sheep as they initiate the activity of hypothalamic-pituitary-ovarian axis. Also hormones of thyrotropic axis are probably involved in this process. The aim of study was to analyze the impact of leptin on kisspeptin-10 secretion as well as kisspeptin-1 and G protein-coupled receptor (GPR54) mRNA expression in pituitary cells of pubertal ewes in vitro. The influence of kisspeptin on TSH secretion was also examined. Cells were cultured in McCoy's 5A medium without hormones; with 10(-10)-10(-5)M of leptin; with 10(-11)-10(-5)M of kisspeptin-10; with peptide 234 (10(-7)M, antagonist of GPR54) or 10(-11)-10(-5)M of kisspeptin-10 and peptide 234...
April 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/26973595/kisspeptin-activates-ankrd-26-gene-expression-in-migrating-embryonic-gnrh-neurons
#16
Tomoko Soga, Wei Ling Lim, Alan Soo-Beng Khoo, Ishwar S Parhar
Kisspeptin, a newly discovered neuropeptide, regulates gonadotropin-releasing hormone (GnRH). Kisspeptins are a large RF-amide family of peptides. The kisspeptin coded by KiSS-1 gene is a 145-amino acid protein that is cleaved to C-terminal peptide kisspeptin-10. G-protein-coupled receptor 54 (GPR54) has been identified as a kisspeptin receptor, and it is expressed in GnRH neurons and in a variety of cancer cells. In this study, enhanced green fluorescent protein (EGFP) labeled GnRH cells with migratory properties, which express GPR54, served as a model to study the effects of kisspeptin on cell migration...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/26899179/transcripts-of-genes-encoding-reproductive-neuroendocrine-hormones-and-androgen-receptor-in-the-brain-and-testis-of-goldfish-exposed-to-vinclozolin-flutamide-testosterone-and-their-combinations
#17
Mahdi Golshan, Hamid R Habibi, Sayyed Mohammad Hadi Alavi
Vinclozolin (VZ) is a pesticide that acts as an anti-androgen to impair reproduction in mammals. However, VZ-induced disruption of reproduction is largely unknown in fish. In the present study, we have established a combination exposure in which adult goldfish were exposed to VZ (30 and 100 μg/L), anti-androgen flutamide (Flu, 300 μg/L), and androgen testosterone (T, 1 μg/L) to better understand effects of VZ on reproductive endocrine system. mRNA levels of kisspeptin (kiss-1 and kiss-2) and its receptor (gpr54), salmon gonadotropin-releasing hormone (gnrh3) and androgen receptor (ar) in the mid-brain, and luteinizing hormone receptor (lhr) in the testis were analyzed and compared with those of control following 10 days of exposure...
August 2016: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/26853724/effects-of-high-fat-diet-induced-obesity-and-diabetes-on-kiss1-and-gpr54-expression-in-the-hypothalamic-pituitary-gonadal-hpg-axis-and-peripheral-organs-fat-pancreas-and-liver-in-male-rats
#18
M Dudek, P A Kołodziejski, E Pruszyńska-Oszmałek, M Sassek, K Ziarniak, K W Nowak, J H Sliwowska
Recent data indicates that kisspeptin, encoded by the KISS1 gene, could play a role in transducing metabolic information into the hypothalamic-pituitary-gonadal (HPG) axis, the mechanism that controls reproductive functions. Numerous studies have shown that in a state of negative energy balance, the hypothalamic kisspeptin system is impaired. However, data concerning positive energy balance (e.g. diabetes and obesity) and the role of kisspeptin in the peripheral tissues is scant. We hypothesized that: 1) in diet-induced obese (DIO) male rats and/or rats with diabetes type 1 (DM1) and type 2 (DM2), altered reproductive functions are related to an imbalance in Kiss1 and GPR54 mRNA in the HPG axis; and 2) in DIO and/or DM1 and/or DM2 rats, Kiss1 and GPR 54 expression are altered in the peripheral tissues involved in metabolic functions (fat, pancreas and liver)...
April 2016: Neuropeptides
https://www.readbyqxmd.com/read/26833836/hypothalamic-control-of-the-male-neonatal-testosterone-surge
#19
REVIEW
Jenny Clarkson, Allan E Herbison
Sex differences in brain neuroanatomy and neurophysiology underpin considerable physiological and behavioural differences between females and males. Sexual differentiation of the brain is regulated by testosterone secreted by the testes predominantly during embryogenesis in humans and the neonatal period in rodents. Despite huge advances in understanding how testosterone, and its metabolite oestradiol, sexually differentiate the brain, little is known about the mechanism that actually generates the male-specific neonatal testosterone surge...
February 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/26726951/divergent-regulation-of-er-and-kiss-genes-by-17%C3%AE-estradiol-in-hypothalamic-arc-versus-avpv-models
#20
Alice K Treen, Vicky Luo, Jennifer A Chalmers, Prasad S Dalvi, Dean Tran, Wenqing Ye, Ginah L Kim, Zoey Friedman, Denise D Belsham
Kisspeptin (Kiss) and G-protein-coupled receptor (Gpr)54 have emerged as key regulators of reproduction. 17β-estradiol (E2)-mediated regulation of these neurons is nuclei specific, where anteroventral periventricular (AVPV) Kiss neurons are positively regulated by E2, whereas arcuate nucleus (ARC) neurons are inhibited. We have generated immortalized Kiss cell lines from male and female adult-derived murine hypothalamic primary culture, as well as cell lines from microdissected AVPV and ARC from female Kiss-green fluorescent protein (GFP) mice...
February 2016: Molecular Endocrinology
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