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A1166C polymorphism

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https://www.readbyqxmd.com/read/27816405/atrial-flutter-fibrillation-in-patients-receiving-transcatheter-closure-of-atrial-septal-defect
#1
Shuenn-Nan Chiu, Mei-Hwan Wu, Chia-Ti Tsai, Ling-Ping Lai, Jiunn-Lee Lin, Ming-Tai Lin, Chun-Wei Lu, Jou-Kou Wang
BACKGROUND/PURPOSE: Atrial flutter/fibrillation (AFL/Af) is a common late complication in atrial septal defect (ASD) patients even after occluder implantation. We try to delineate the risk factors of persistent AFL/Af. METHODS: From 1998 to 2010, all patients older than 18 years of age who received ASD occluder implantation in our hospital were enrolled, and their records were retrospectively reviewed. In addition, renin-angiotensin system gene polymorphisms including angiotensinogen gene, A1166C polymorphism on the angiotensin II type I receptor gene, and insertion/deletion (I/D) patterns on the angiotensin-converting enzyme gene were checked using direct sequencing...
November 2, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27753954/os-08-04-epistatic-and-sex-dependent-association-analyses-of-genes-of-the-renin-angiotensin-aldosterone-system-and-blood-pressure-in-families
#2
Stephen Harrap, Katrina Scurrah, Angela Lamantia, Justine Ellis
OBJECTIVE: Genes encoding key elements of the renin-angiotensin-aldosterone system (RAAS) cascade have been previously but inconsistently associated with blood pressure. Sex-dependency might be important here and functional genetic polymorphisms might exhibit epistatic effects. DESIGN AND METHOD: We assessed variation in the genes encoding renin (REN), angiotensinogen (AGT), angiotensin converting enzyme (ACE), angiotensin II type 1 receptor (AGTR1) and aldosterone synthase (CYP11B2)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753829/sy-03-2-pathophysiologic-significance-of-non-coding-rna-in-hypertension
#3
Stephen Harrap
Genetic discovery in blood pressure is generally referenced in relation to protein-coding genes, despite the fact that genes less than 2% of the genome. Recent exploration of the DNA sequences between genes, once called "junk" DNA, has revealed a wealth of transcripts for RNA species that do not encode protein. These non-coding RNAs (ncRNAs) have emerged as dynamic managers of the business of the genome, able to coordinate the expression of genes in time and space to achieve the complexities of normal development and growth...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643349/os-08-04-epistatic-and-sex-dependent-association-analyses-of-genes-of-the-renin-angiotensin-aldosterone-system-and-blood-pressure-in-families
#4
Stephen Harrap, Katrina Scurrah, Angela Lamantia, Justine Ellis
OBJECTIVE: Genes encoding key elements of the renin-angiotensin-aldosterone system (RAAS) cascade have been previously but inconsistently associated with blood pressure. Sex-dependency might be important here and functional genetic polymorphisms might exhibit epistatic effects. DESIGN AND METHOD: We assessed variation in the genes encoding renin (REN), angiotensinogen (AGT), angiotensin converting enzyme (ACE), angiotensin II type 1 receptor (AGTR1) and aldosterone synthase (CYP11B2)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642882/sy-03-2-pathophysiologic-significance-of-non-coding-rna-in-hypertension
#5
Stephen Harrap
Genetic discovery in blood pressure is generally referenced in relation to protein-coding genes, despite the fact that genes less than 2% of the genome. Recent exploration of the DNA sequences between genes, once called "junk" DNA, has revealed a wealth of transcripts for RNA species that do not encode protein. These non-coding RNAs (ncRNAs) have emerged as dynamic managers of the business of the genome, able to coordinate the expression of genes in time and space to achieve the complexities of normal development and growth...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27492398/analysis-of-polymorphism-of-angiotensin-system-genes-ace-agtr1-and-agt-and-gene-itgb3-in-patients-with-arterial-hypertension-in-combination-with-metabolic-syndrome
#6
T Yu Zotova, A P Kubanova, M M Azova, A Ait Aissa, O O Gigani, V A Frolov
Changes in the frequencies of genotypes and mutant alleles of ACE, AGTR1, AGT, and ITGB3 genes were analyzed in patients with arterial hypertension coupled with metabolic syndrome (N=15) and compared with population data and corresponding parameters in patients with isolated hypertension (N=15). Increased frequency of genotype ID of ACE gene (hypertension predictor) was confirmed for both groups. In case of isolated hypertension, M235M genotype (gene AGT) was more frequent, in case of hypertension combined with metabolic syndrome, the frequency of genotypes A1166C and C1166C of the gene AGTR1 was higher in comparison with population data...
July 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27339867/blood-pressure-arterial-stiffness-and-endogenous-lithium-clearance-in-relation-to-agtr1-a1166c-and-agtr2-g1675a-gene-polymorphisms
#7
Marcin Cwynar, Jerzy Gąsowski, Anna Głuszewska, Jarosław Królczyk, Henryk Bartoń, Agnieszka Słowik, Tomasz Grodzicki
INTRODUCTION: Although recently a matter of epidemiologic controversy, sodium overload and its interaction with genetic factors predispose to hypertension and related target organ complications. METHODS: In 131 (66 male) treated hypertensives, we measured peripheral and central arterial pressures and pulse wave augmentation indexes (AIx(P), AIx(C1), AIx(C2)), pulse wave velocity (PWV), daily urinary sodium excretion and did genetic studies of AGTR1 A1166C and AGTR2 G1675A polymorphisms...
April 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/27068935/renin-angiotensin-system-gene-polymorphisms-and-endometrial-cancer
#8
Kirsty G Pringle, Sarah J Delforce, Yu Wang, Katie A Ashton, Anthony Proietto, Geoffrey Otton, C Caroline Blackwell, Rodney J Scott, Eugenie R Lumbers
Endometrial cancer (EC) is the most common gynaecological malignancy and its incidence is increasing. Dysregulation of the endometrial renin-angiotensin system (RAS) could predispose to EC; therefore, we studied the prevalence of RAS single nucleotide polymorphisms (SNPs) in Australian women with EC. SNPs assessed were AGT M235T (rs699); AGTR1 A1166C (rs5186); ACE A240T and T93C (rs4291, rs4292) and ATP6AP2 (rs2968915). They were identified using TaqMan SNP Genotyping Assays. The C allele of the AGTR1 SNP (rs5186) was more prevalent in women with EC (odds ratio (OR) 1...
May 2016: Endocrine Connections
https://www.readbyqxmd.com/read/27050965/analysis-of-correlations-between-coronary-heart-disease-and-haplotypes-of-the-angiotensin-ii-receptor-type-1-agtr1-gene
#9
L J Duan, X D Wang
This study aimed to explore correlations between haplotypes of the angiotensin II receptor type 1 (AGTR1) gene and coronary heart disease (CHD). In total, 204 patients with CHD and 206 healthy controls were genotyped using denaturing high-performance liquid chromatography between 2008 and 2014. Five polymorphic loci were found, namely, A-43281G, A-32954G, G-32839A, G-11064A, and A1880G. Likelihood estimates were used to identify haplotypes consisting of the A1166C locus and four of these five loci, then correlations between these haplotypes and CHD were assessed...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27016615/angiotensin-receptor-type-1-polymorphism-a1166c-is-associated-with-altered-at1r-and-mir-155-expression-in-carotid-plaque-tissue-and-development-of-hypoechoic-carotid-plaques
#10
Aleksandra Stanković, Ana Kolaković, Maja Živković, Tamara Djurić, Maja Bundalo, Igor Končar, Lazar Davidović, Dragan Alavantić
BACKGROUND AND AIMS: The principal biologic effects of the renin-angiotensin system are mediated by activation of the AT1R receptor. The microRNA miR-155 regulates AT1R expression, with both its, and AT1R's activity, linked to atherosclerosis. Target sites for miR-155 lie within the 3' UTR of the human AT1R gene, and include the AT1R A1166C polymorphism. Thus far, only levels of circulating miR-155 have been investigated with respect to A1166C genotypes. We hypothesized that the A1166C polymorphism could correlate with different, ultra-sonographically defined plaque phenotypes, as well as with an altered expression of AT1R mRNA and protein in human carotid plaques (CP), and altered expression of miR-155 in patients with advanced atherosclerosis...
May 2016: Atherosclerosis
https://www.readbyqxmd.com/read/26699833/retraction-notice
#11
(no author information available yet)
The following articles have been retracted at the request of the Editors and the Publisher.After conducting a thorough investigation, SAGE found that the submitting authors of a number of papers published in the Journal of the Renin-Angiotensin Aldosterone System (JRAAS) (listed below) had supplied fabricated contact details for their nominated reviewers. The Editors accepted these papers based on the reports supplied by the individuals using these fake reviewer email accounts. After concluding that the peer review process was therefore seriously compromised, SAGE and the journal Editors have decided to retract all affected articles...
December 2015: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/26670794/association-of-polymorphisms-in-endothelial-nitric-oxide-synthesis-and-renin-angiotensin-aldosterone-system-with-developing-of-coronary-artery-disease-in-bulgarian-patients
#12
Katya Mokretar, Hristo Velinov, Arman Postadzhiyan, Margarita Apostolova
AIM: The purpose of this study was to evaluate the association of common polymorphisms in endothelial nitric oxide synthesis (eNOS; G894T) and renin-angiotensin-aldosterone system (angiotensin converting enzyme [ACE]-I/D, angiotensinogen-T704C, and angiotensin II receptor type 1-A1166C) as risk factors in the pathogenesis of coronary artery disease (CAD) in Bulgarian patients. METHODS: This study included 171 patients with CAD and 123 control subjects. Polymerase chain reaction-restriction fragment length polymorphism was used for studying the single-nucleotide polymorphisms...
February 2016: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/26634463/angiotensin-ii-type-1-receptor-gene-a1166c-polymorphism-and-breast-cancer-susceptibility
#13
L Li, F Wang, P W Lv, M Z Zhu, J J He, G C Guo, Y T Gu, M L Han
Numerous studies have evaluated the association between the angiotensin II type-1 receptor (AGTR1) gene A1166C polymorphism and breast cancer risk. However, the specific association is controversial. The aim of the present study was to derive a more precise estimation of the relationship. A comprehensive research was conducted of the PubMed and the Google Scholar databases through February 2015. Data were assessed using STATA version 12.0. Pooled odds ratios with 95%CIs were derived from the fixed-effect or random-effect models...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26599707/pretreatment-with-antioxidants-augments-the-acute-arterial-vasoconstriction-caused-by-diesel-exhaust-inhalation
#14
Cora S Sack, Karen L Jansen, Kristen E Cosselman, Carol A Trenga, Pat L Stapleton, Jason Allen, Alon Peretz, Casey Olives, Joel D Kaufman
RATIONALE: Diesel exhaust inhalation, which is the model traffic-related air pollutant exposure, is associated with vascular dysfunction. OBJECTIVES: To determine whether healthy subjects exposed to diesel exhaust exhibit acute vasoconstriction and whether this effect could be modified by the use of antioxidants or by common variants in the angiotensin II type 1 receptor (AGTR1) and other candidate genes. METHODS: In a genotype-stratified, double-blind, four-way crossover study, 21 healthy adult subjects were exposed at rest in a randomized, balanced order to diesel exhaust (200 μg/m(3) particulate matter with an aerodynamic diameter ≤ 2...
May 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26588355/lack-of-association-between-polymorphisms-in-agt-and-atr1-and-iga-nephropathy-in-a-chinese-population
#15
Jie Gao, Qiao-Ling Yu, Rong-Guo Fu, Lin-Ting Wei, Meng Wang, Feng-Ming Dong, Zhe Wang, Peng-Tao Yang, Xing-Han Liu, Zhi-Jun Dai
OBJECTIVE: The mechanism of immunoglobulin A nephropathy (IgAN) remains unclear. Genetic factors may be associated with the risk of IgAN. This study aims to identify the possible association of M268T (rs699) in the Angiotensinogen (AGT) gene and A1166C (rs5186) in the Angiotensin II receptor type 1 (ATR1) gene with IgAN risk. METHODS: Study subjects included 351 patients with IgAN and 310 controls from the Chinese population. The tag SNPs (tSNPs) were genotyped by Sequenom MassARRAY RS1000...
December 2015: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/26524813/at1r-a1166c-polymorphism-and-risk-of-pregnancy-induced-hypertension-a-meta-analysis-of-case-control-studies
#16
H Y Wang, X Q He, Z G Wang, M Fan, H X Liu
PURPOSE: The purpose of this study was to perform a quantitative review of previous case control studies examining the association between AT1R A1166C polymorphism and pregnancy-induced hypertension (PIH). MATERIALS AND METHODS: Odds ratio (OR) and 95% confidence intervals (CI) were used as measures of effect sizes. Overall effect sizes were derived using a random-effects model or fixed-effects model when appreciated, and stratified by ethnicity. Funnel plots and Egger's regression asymmetry tests were utilized for publication bias detection...
2015: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26509357/genetic-variants-in-the-renin-angiotensin-system-predict-response-to-bevacizumab-in-cancer-patients
#17
Diana Moreno-Muñoz, Juan R de la Haba-Rodríguez, Francisco Conde, Laura M López-Sánchez, Araceli Valverde, Vanessa Hernández, Antonio Martínez, Carlos Villar, Auxiliadora Gómez-España, Ignacio Porras, Antonio Rodríguez-Ariza, Enrique Aranda
BACKGROUND: Currently, there are no predictive biomarkers for anti-angiogenic strategies in cancer, but response to anti-angiogenic drugs is associated with development of hypertension secondary to treatment. Therefore, this study explored the clinical relevance of genetic polymorphisms in some components of the renin-angiotensin system (RAS). MATERIAL AND METHODS: Genomic DNA was isolated from peripheral blood from 95 metastatic breast or colorectal cancer patients treated with bevacizumab, and AGTR1-A1166C (rs5186), AGT-M235T (rs699) SNPs and ACE I/D (rs4646994) polymorphisms were genotyped using RT-PCR...
December 2015: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/26380021/association-of-atrial-fibrillation-with-gene-polymorphisms-of-connexin-40-and-angiotensin-ii-receptor-type-1-in-chongming-adults-of-shanghai
#18
Shuxin Hou, Yingmin Lu, Damin Huang, Xiaohan Luo, Dongmei Yue, Jinchun Zhang
OBJECTIVE: To characterized the gene polymorphisms of connexin 40 (cx40) and angiotensin II receptor type 1 (AT1R) in Chongming adults with atrial fibrillation (AF) and to explore their relationships with AF. METHODS: 82 patients with AF, and 82 subjects without AF were enrolled. Polymorphisms of cx40 G-44A and AT1 A1166C were detected. Moreover, several samples were randomly selected to validate the gene polymorphisms of cx40 and AT1. RESULTS: Genotypes AA, AG and GG of cx40 G-44A were found in both AF patients and controls...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26345849/association-of-agtr1-gene-a1166c-polymorphism-with-the-risk-of-heart-failure-a-meta-analysis
#19
J A Zhang, J R Li, Y J Qiao
The aim of this study was to investigate the correlation between the A1166C polymorphism in the angiotensin II type 1 receptor (AT1R) gene and heart failure (HF) risk using meta‑analysis. The PubMed database was searched, and data were extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the associations. Statistical analysis was performed using the STATA 12.0 software. The results of the meta‑analysis showed no significant association between the AT1R A1166C polymorphism and HF risk (AA vs CC: OR = 0...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26310144/at1r-a1166c-variants-in-patients-with-type-2-diabetes-mellitus-and-diabetic-nephropathy
#20
Mahmoudreza Moradi, Zohreh Rahimi, Sonia Amiri, Ziba Rahimi, Mahmood Vessal, Hamid Nasri
BACKGROUND: There are inconsistent reports related to the role of angiotensin II type 1 receptor (AT1R) on the risk of type 2 diabetes mellitus (T2DM) and its renal complications. OBJECTIVES: To identify the association between AT1R A1166C variants with the risk of T2DM and also with diabetic nephropathy (DN). PATIENTS AND METHODS: In a case-control study, the AT1R A1166C polymorphism was detected in 135 T2DM patients with and without DN and in 98 healthy subjects from Western Iran...
July 2015: Journal of Nephropathology
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