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Prilocaine

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https://www.readbyqxmd.com/read/28284831/plga-implants-how-poloxamer-peo-addition-slows-down-or-accelerates-polymer-degradation-and-drug-release
#1
M C Hamoudi-Ben Yelles, V Tran Tan, F Danede, J F Willart, J Siepmann
The aim of this study was to evaluate the impact of the addition of small amounts of hydrophilic polymers (Poloxamer 188 and PEO 200kDa) to PLGA-based implants loaded with prilocaine. Special emphasis was placed on the importance of the type of preparation technique: direct compression of milled drug-polymer powder blends versus compression of drug loaded microparticles (prepared by spray-drying). The implants were thoroughly characterized before and upon exposure to phosphate buffer pH7.4, e.g. using optical and scanning electron microscopy, X-ray diffraction, DSC and GPC...
March 9, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28236870/neuraxial-anesthesia-after-local-anesthesia-for-management-of-percutaneous-vertebroplasty-complication-during-vertebroplasty
#2
Hüseyin Balkarlı, Mesut Kılıç, İbrahim Öztürk
Percutaneous vertebroplasty is a relatively safe, simple and commonly performed interventional procedure for the management of vertebral compression fractures. However, serious complications are rarely reported in the procedure. Those are pulmonary embolism, severe infection, paraplegia and an occurrence of a new fracture in an adjacent vertebra after vertebroplasty. Acute complications are generally associated with the procedure. We present the case of neuraxial anesthesia, developed after local anesthesia with 8mL of 2% prilocaine, in a 68-year-old woman who underwent percutaneous vertebroplasty after an osteoporotic collapsed fracture in the L1 vertebra due to trauma...
March 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/28230244/topical-anaesthetics-for-pain-control-during-repair-of-dermal-laceration
#3
REVIEW
Baraa O Tayeb, Anthony Eidelman, Cristy L Eidelman, Ewan D McNicol, Daniel B Carr
BACKGROUND: Topical local anaesthetics provide effective analgesia for patients undergoing numerous superficial procedures, including repair of dermal lacerations. The need for cocaine in topical anaesthetic formulations has been questioned because of concern about adverse effects, thus novel preparations of cocaine-free anaesthetics have been developed. This review was originally published in 2011 and has been updated in 2017. OBJECTIVES: To assess whether benefits of non-invasive topical anaesthetic application occur at the expense of decreased analgesic efficacy...
February 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28196085/what-device-would-be-best-for-early-infant-male-circumcision-in-east-and-southern-africa-provider-experiences-and-opinions-with-three-different-devices-in-kenya
#4
Robert C Bailey, Irene Nyaboke, Fredrick O Otieno
Voluntary medical male circumcision (VMMC) reduces risk of HIV acquisition in heterosexual men by approximately 60%. As some countries approach targets for proportions of adolescents and adults circumcised, some are considering early infant male circumcision (EIMC) as a means to achieve sustainability of VMMC for long term reduction of HIV incidence. Evaluations of specialized devices for EIMC are important to provide programs with information required to make informed decisions about how to design safe, effective EIMC programs...
2017: PloS One
https://www.readbyqxmd.com/read/28181622/a-framework-for-multi-scale-simulation-of-crystal-growth-in-the-presence-of-polymers
#5
Taraknath Mandal, Wenjun Huang, Jodi M Mecca, Ashley Getchell, William W Porter, Ronald G Larson
We present a multi-scale simulation method for modeling crystal growth in the presence of polymer excipients. The method includes a coarse-grained (CG) model for small molecules of known crystal structure whose force field is obtained using structural properties from atomistic simulations. This CG model is capable of stabilizing the molecular crystal structure and capturing the crystal growth from the melt for a wide range of small organic molecules, as demonstrated by application of our method to the molecules isoniazid, urea, sulfamethoxazole, prilocaine, oxcarbazepine, and phenytoin...
February 9, 2017: Soft Matter
https://www.readbyqxmd.com/read/28130888/first-time-success-with-needle-procedures-was-higher-with-a-warm-lidacaine-and-tetracaine-patch-than-an-eutectic-mixture-of-lidocaine-and-prilocaine-cream
#6
Giorgio Cozzi, Fabio Borrometi, Franca Benini, Elena Neri, Francesca Rusalen, Loredana Celentano, Davide Zanon, Silvana Schreiber, Luca Ronfani, Egidio Barbi
AIM: More than 50% of children report apian during venipuncture or intravenous cannulation and using local anaesthetics before needle procedures can lead to different success rates. This study examined how many needle procedures were successful at the first attempt when children received either a warm lidocaine and tetracaine patch or an eutectic mixture of lidocaine and prilocaine (EMLA) cream. METHODS: We conducted this multicentre randomised controlled trial at three tertiary-level children's hospitals in Italy in 2015...
January 27, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28079154/local-anesthesia-for-transrectal-ultrasound-guided-biopsy-of-the-prostate-a-meta-analysis
#7
Mingchao Li, Zhengyun Wang, Hao Li, Jun Yang, Ke Rao, Tao Wang, Shaogang Wang, Jihong Liu
A meta-analysis was performed to evaluate the efficacy of local anesthesia in alleviating pain during prostate biopsy. We searched relevant articles in PubMed and Embase. The included studies should be randomized controlled trials (RCT) using local anesthesia to alleviate pain during biopsy, which was recorded by a pain scale. Analgesic efficacy of different local anesthesia techniques were analyzed, including intrarectal local anesthesia (IRLA), periprostatic nerve block (PNB), pelvic plexus block (PPB) and intraprostatic local anesthesia (IPLA)...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28073199/transrectal-ultrasound-trus-guided-prostate-biopsy-three-different-types-of-local-anesthesia
#8
Giuseppina Anastasi, Enrica Subba, Rosa Pappalardo, Luciano Macchione, Gioacchino Ricotta, Graziella Muscarà, Francesco Lembo, Carlo Magno
Transrectal Ultrasound (TRUS) guided prostate biopsy is regarded as the gold standard for prostate cancer diagnosis. The majority of patients perceive TRUS-guided prostate biopsy as a physically and psychologically traumatic experience. We aimed to compare in this paper the efficacy of three different anesthesia techniques to control the pain during the procedure. MATERIALS AND METHODS: 150 patients who underwent transrectal ultrasound (TRUS) guided prostate biopsy were randomly divided into three groups...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28066874/the-effect-of-a-lidocaine-prilocaine-topical-anesthetic-on-pain-and-discomfort-associated-with-orthodontic-elastomeric-separator-placement
#9
M Abu Al-Melh, L Andersson
BACKGROUND: The initial placement of orthodontic elastomeric separators can be uncomfortable and painful. Therefore, it is important to relieve this disturbing sensation to create a discomfort or pain-free orthodontic visit. The purpose of this study was to investigate the effect of a lidocaine/prilocaine topical anesthetic on pain and discomfort associated with the placement of orthodontic elastomeric separators. METHODS: Fifty subjects aging between 20-35 years were included in this study...
December 2017: Progress in Orthodontics
https://www.readbyqxmd.com/read/28017670/presynaptic-facilitation-by-tetracaine-of-glutamatergic-spontaneous-excitatory-transmission-in-the-rat-spinal-substantia-gelatinosa-involvement-of-trpa1-channels
#10
Lian-Hua Piao, Tsugumi Fujita, Ting Yu, Eiichi Kumamoto
The amide-type local anesthetic (LA) lidocaine activates transient receptor potential (TRP) ankyrin-1 (TRPA1) channels to facilitate spontaneous L-glutamate release onto spinal substantia gelatinosa (SG) neurons, which play a crucial role in regulating nociceptive transmission. In contrast, the ester-type LA procaine reduces the spontaneous release of L-glutamate in SG neurons. In order to determine whether TRPA1 activation by LAs is specific to amide-types, we examined the actions of tetracaine, another ester-type LA, and other amide-type LAs on glutamatergic spontaneous excitatory transmission in SG neurons by focusing on TRP activation...
December 22, 2016: Brain Research
https://www.readbyqxmd.com/read/28017546/a-double-blind-randomized-prospective-study-comparing-prilocaine-versus-ropivacaine-in-upper-blepharoplasty
#11
Florian Ensat, Klemens Heinrich, Hassan Mahmoud Kholosy, Julia Wimbauer, Michaela Hladik, Gottfried Wechselberger
BACKGROUND: Upper blepharoplasties are a common procedure in plastic surgery. This procedure can be performed effectively under local anesthesia with or without sedation. The ideal local anesthetic should cause less intraoperative bleeding and less postoperative edema. Our study aimed to show the difference between the two local anesthetics 1% prilocaine (Xylonaest) in combination with epinephrine 1:100,000 and ropivacaine (Naropin) in combination with epinephrine 1:100,000 including sodium chloride, particularly in regard to swelling and bleeding in patients undergoing upper blepharoplasties...
November 19, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27831940/pseudo-bullous-dermatosis-induced-by-topical-anesthetic-agent-clues-to-this-localized-toxic-reaction
#12
Christopher R Kieliszak, John R Griffin, Tess H Pollinger, Jacqueline M Junkins-Hopkins
Eutectic mixture of 2.5% lidocaine and 2.5% prilocaine (EMLA AstraZeneca, DE) is a widely used topical anesthetic cream for preprocedural cutaneous analgesia. In addition to potential clinical cutaneous and systemic adverse effects, EMLA may also induce microscopic changes detectable by light and electron microscopy leading to difficulty in accurate diagnosis. We report the case of a biopsy demonstrating EMLA-induced histopathologic changes. The biopsy was taken from the back of a 5-month-old infant and submitted to rule out psoriasis...
February 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27823944/effect-of-cervical-lidocaine-prilocaine-cream-on-pain-perception-during-copper-t380a-intrauterine-device-insertion-among-parous-women-a-randomized-double-blind-controlled-trial
#13
Ahmed M Abbas, Mohamed S Abdellah, Mohamed Khalaf, Mustafa Bahloul, Noura H Abdellah, Mohamed K Ali, Ahmed M Abdelmagied
OBJECTIVE: The objective was to investigate the analgesic effect of cervical lidocaine-prilocaine (LP) cream in alleviating pain during copper T380A intrauterine device (IUD) insertion among parous women. STUDY DESIGN: We conducted a randomized, double-blind, placebo-controlled trial at Assiut Women's Health Hospital, Egypt, from October 2015 to April 2016 of parous women desiring copper IUD insertion. We randomized the subjects in a 1:1 ratio to LP cream or placebo...
March 2017: Contraception
https://www.readbyqxmd.com/read/27747692/a-12-day-old-boy-with-methemoglobinemia-after-circumcision-with-local-anesthesia-lidocaine-prilocaine
#14
Evelien Kuiper-Prins, Gerthe Femke Kerkhof, Catharina Gertrudis Maria Reijnen, Pieter Jan van Dijken
A 12-day-old boy presented with duskiness 4 h after circumcision with local anesthesia: infiltration with lidocaine (6 mL 1 %) and topical EMLA cream (2.5 % lidocaine/2.5 % prilocaine). He had no respiratory distress, but a strikingly dark skin. A blood sample showed dark, chocolate brown blood with a raised methemoglobin of 49.8 % (normal <1.5 %) and a lactate of 10 mmol/L. A diagnosis of methemoglobinemia was made. The patient was treated with oxygen administration, but methemoglobin concentration was still 45 % 1 h later...
December 2016: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27746520/the-efficacy-of-eutectic-mixture-of-local-anesthetics-as-a-topical-anesthetic-agent-used-for-dental-procedures-a-brief-review
#15
REVIEW
Alireza Daneshkazemi, Seyyed Mohammad Abrisham, Pedram Daneshkazemi, Amin Davoudi
Dental pain management is one of the most critical aspects of modern dentistry which might affect patient's quality of life. Several methods are suggested to provide a painless situation for patients. Desensitization of the oral site using topical anesthetics is one of those methods. The improvements of topical anesthetic agents are probably one of the most important advances in dental science in the past 100 years. Most of them are safe and can be applied on oral mucosa with minimal irritation and allergic reactions...
September 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/27742968/ultrasound-guided-intermediate-cervical-plexus-block-and-perivascular-local-anesthetic-infiltration-for-carotid-endarterectomy-a%C3%A2-randomized-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
R Seidel, K Zukowski, A Wree, M Schulze
BACKGROUND AND OBJECTIVE: Ultrasound-guided blocks of the cervical plexus are established anesthetic procedures for carotid endarterectomy. This randomized, double-blind, placebo-controlled study tested the hypothesis that an additional ultrasound-guided periarterial injection of local anesthetic leads to a lower frequency of periarterial supplementation by the surgeon. METHODS: A total of 40 patients were randomly assigned to 1 of 2 groups. In both groups an ultrasound-guided intermediate cervical plexus block (20 ml of 0...
December 2016: Der Anaesthesist
https://www.readbyqxmd.com/read/27716943/paracetamol-acetaminophen-for-prevention-or-treatment-of-pain-in-newborns
#17
REVIEW
Arne Ohlsson, Prakeshkumar S Shah
BACKGROUND: Newborn infants have the ability to experience pain. Hospitalised infants are exposed to numerous painful procedures. Healthy newborns are exposed to pain if the birth process consists of assisted vaginal birth by vacuum extraction or by forceps and during blood sampling for newborn screening tests. OBJECTIVES: To determine the efficacy and safety of paracetamol for the prevention or treatment of procedural/postoperative pain or pain associated with clinical conditions in neonates...
October 7, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27665091/a-randomized-trial-on-the-efficacy-of-topical-anesthesia-for-pain-reduction-during-frame-placement-for-gamma-knife-radiosurgery
#18
Sean Michael Duenas, Jonathan Pun, Hesham A Radwan, Meredith Akerman, Michael Schulder
BACKGROUND/AIMS: Frame application for gamma knife radiosurgery (GKR) may be perceived as painful by patients. This study was designed to assess the efficacy of EMLA (2.5% lidocaine/2.5% prilocaine) in pain reduction. METHODS: This was a prospective, randomized, and controlled trial approved by our institutional review board. Fifty-four patients undergoing outpatient GKR were divided into EMLA and placebo groups. Prior to frame placement, EMLA/placebo was applied to the patient's forehead...
September 24, 2016: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/27637996/-neuraxial-anesthesia-after-local-anesthesia-for-management-of-percutaneous-vertebroplasty-complication-during-vertebroplasty
#19
Hüseyin Balkarlı, Mesut Kılıç, İbrahim Öztürk
Percutaneous vertebroplasty is a relatively safe, simple and commonly performed interventional procedure for the management of vertebral compression fractures. However, serious complications are rarely reported in the procedure. Those are pulmonary embolism, severe infection, paraplegia and an occurrence of a new fracture in an adjacent vertebra after vertebroplasty. Acute complications are generally associated with the procedure. We present the case of neuraxial anesthesia, developed after local anesthesia with 8mL of 2% prilocaine, in a 68-year-old woman who underwent percutaneous vertebroplasty after an osteoporotic collapsed fracture in the L1 vertebra due to trauma...
March 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/27617615/effective-local-anesthesia-for-onabotulinumtoxin-a-injections-to-treat-hyperhidrosis-associated-with-traumatic-amputation
#20
Lucy L Shi, Michael R Sargen, Suephy C Chen, Jack L Arbiser, Brian P Pollack
BACKGROUND: Botulinum toxin type A (BTX-A) injections are an effective treatment for controlling hyperhidrosis at sites of amputation. Hyperesthesia associated with amputated limbs is a major barrier to performing this procedure under local anesthesia. OBJECTIVE: To present a novel method for improving local anesthesia with BTX-A injections. Methods & RESULTS: A 29-year-old military veteran with a below-the-knee amputation of his right leg was suffering from amputation site hyperhidrosis, which was impeding his ability to comfortably wear a prosthesis...
June 15, 2016: Dermatology Online Journal
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