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https://www.readbyqxmd.com/read/28079154/local-anesthesia-for-transrectal-ultrasound-guided-biopsy-of-the-prostate-a-meta-analysis
#1
Mingchao Li, Zhengyun Wang, Hao Li, Jun Yang, Ke Rao, Tao Wang, Shaogang Wang, Jihong Liu
A meta-analysis was performed to evaluate the efficacy of local anesthesia in alleviating pain during prostate biopsy. We searched relevant articles in PubMed and Embase. The included studies should be randomized controlled trials (RCT) using local anesthesia to alleviate pain during biopsy, which was recorded by a pain scale. Analgesic efficacy of different local anesthesia techniques were analyzed, including intrarectal local anesthesia (IRLA), periprostatic nerve block (PNB), pelvic plexus block (PPB) and intraprostatic local anesthesia (IPLA)...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28073199/transrectal-ultrasound-trus-guided-prostate-biopsy-three-different-types-of-local-anesthesia
#2
Giuseppina Anastasi, Enrica Subba, Rosa Pappalardo, Luciano Macchione, Gioacchino Ricotta, Graziella Muscarà, Francesco Lembo, Carlo Magno
: Transrectal Ultrasound (TRUS) guided prostate biopsy is regarded as the gold standard for prostate cancer diagnosis. The majority of patients perceive TRUS-guided prostate biopsy as a physically and psychologically traumatic experience. We aimed to compare in this paper the efficacy of three different anesthesia techniques to control the pain during the procedure. MATERIALS AND METHODS: 150 patients who underwent transrectal ultrasound (TRUS) guided prostate biopsy were randomly divided into three groups...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28066874/the-effect-of-a-lidocaine-prilocaine-topical-anesthetic-on-pain-and-discomfort-associated-with-orthodontic-elastomeric-separator-placement
#3
M Abu Al-Melh, L Andersson
BACKGROUND: The initial placement of orthodontic elastomeric separators can be uncomfortable and painful. Therefore, it is important to relieve this disturbing sensation to create a discomfort or pain-free orthodontic visit. The purpose of this study was to investigate the effect of a lidocaine/prilocaine topical anesthetic on pain and discomfort associated with the placement of orthodontic elastomeric separators. METHODS: Fifty subjects aging between 20-35 years were included in this study...
December 2017: Progress in Orthodontics
https://www.readbyqxmd.com/read/28017670/presynaptic-facilitation-by-tetracaine-of-glutamatergic-spontaneous-excitatory-transmission-in-the-rat-spinal-substantia-gelatinosa-involvement-of-trpa1-channels
#4
Lian-Hua Piao, Tsugumi Fujita, Ting Yu, Eiichi Kumamoto
The amide-type local anesthetic (LA) lidocaine activates transient receptor potential (TRP) ankyrin-1 (TRPA1) channels to facilitate spontaneous L-glutamate release onto spinal substantia gelatinosa (SG) neurons, which play a crucial role in regulating nociceptive transmission. In contrast, the ester-type LA procaine reduces the spontaneous release of L-glutamate in SG neurons. In order to determine whether TRPA1 activation by LAs is specific to amide-types, we examined the actions of tetracaine, another ester-type LA, and other amide-type LAs on glutamatergic spontaneous excitatory transmission in SG neurons by focusing on TRP activation...
December 22, 2016: Brain Research
https://www.readbyqxmd.com/read/28017546/a-double-blind-randomized-prospective-study-comparing-prilocaine-versus-ropivacaine-in-upper-blepharoplasty
#5
Florian Ensat, Klemens Heinrich, Hassan Mahmoud Kholosy, Julia Wimbauer, Michaela Hladik, Gottfried Wechselberger
BACKGROUND: Upper blepharoplasties are a common procedure in plastic surgery. This procedure can be performed effectively under local anesthesia with or without sedation. The ideal local anesthetic should cause less intraoperative bleeding and less postoperative edema. Our study aimed to show the difference between the two local anesthetics 1% prilocaine (Xylonaest) in combination with epinephrine 1:100,000 and ropivacaine (Naropin) in combination with epinephrine 1:100,000 including sodium chloride, particularly in regard to swelling and bleeding in patients undergoing upper blepharoplasties...
November 19, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27831940/pseudo-bullous-dermatosis-induced-by-topical-anesthetic-agent-clues-to-this-localized-toxic-reaction
#6
Christopher R Kieliszak, John R Griffin, Tess H Pollinger, Jacqueline M Junkins-Hopkins
Eutectic mixture of 2.5% lidocaine and 2.5% prilocaine (EMLA AstraZeneca, DE) is a widely used topical anesthetic cream for preprocedural cutaneous analgesia. In addition to potential clinical cutaneous and systemic adverse effects, EMLA may also induce microscopic changes detectable by light and electron microscopy leading to difficulty in accurate diagnosis. We report the case of a biopsy demonstrating EMLA-induced histopathologic changes. The biopsy was taken from the back of a 5-month-old infant and submitted to rule out psoriasis...
October 26, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27823944/effect-of-cervical-lidocaine-prilocaine-cream-on-pain-perception-during-copper-t380a-intrauterine-device-insertion-among-parous-women-a-randomized-double-blind-controlled-trial
#7
Ahmed M Abbas, Mohamed S Abdellah, Mohamed Khalaf, Mustafa Bahloul, Noura H Abdellah, Mohamed K Ali, Ahmed M Abdelmagied
OBJECTIVE: The objective was to investigate the analgesic effect of cervical lidocaine-prilocaine (LP) cream in alleviating pain during copper T380A intrauterine device (IUD) insertion among parous women. STUDY DESIGN: We conducted a randomized, double-blind, placebo-controlled trial at Assiut Women's Health Hospital, Egypt, from October 2015 to April 2016 of parous women desiring copper IUD insertion. We randomized the subjects in a 1:1 ratio to LP cream or placebo...
November 4, 2016: Contraception
https://www.readbyqxmd.com/read/27747692/a-12-day-old-boy-with-methemoglobinemia-after-circumcision-with-local-anesthesia-lidocaine-prilocaine
#8
Evelien Kuiper-Prins, Gerthe Femke Kerkhof, Catharina Gertrudis Maria Reijnen, Pieter Jan van Dijken
A 12-day-old boy presented with duskiness 4 h after circumcision with local anesthesia: infiltration with lidocaine (6 mL 1 %) and topical EMLA cream (2.5 % lidocaine/2.5 % prilocaine). He had no respiratory distress, but a strikingly dark skin. A blood sample showed dark, chocolate brown blood with a raised methemoglobin of 49.8 % (normal <1.5 %) and a lactate of 10 mmol/L. A diagnosis of methemoglobinemia was made. The patient was treated with oxygen administration, but methemoglobin concentration was still 45 % 1 h later...
December 2016: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27746520/the-efficacy-of-eutectic-mixture-of-local-anesthetics-as-a-topical-anesthetic-agent-used-for-dental-procedures-a-brief-review
#9
REVIEW
Alireza Daneshkazemi, Seyyed Mohammad Abrisham, Pedram Daneshkazemi, Amin Davoudi
Dental pain management is one of the most critical aspects of modern dentistry which might affect patient's quality of life. Several methods are suggested to provide a painless situation for patients. Desensitization of the oral site using topical anesthetics is one of those methods. The improvements of topical anesthetic agents are probably one of the most important advances in dental science in the past 100 years. Most of them are safe and can be applied on oral mucosa with minimal irritation and allergic reactions...
September 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/27742968/ultrasound-guided-intermediate-cervical-plexus-block-and-perivascular-local-anesthetic-infiltration-for-carotid-endarterectomy-a%C3%A2-randomized-controlled-trial
#10
R Seidel, K Zukowski, A Wree, M Schulze
BACKGROUND AND OBJECTIVE: Ultrasound-guided blocks of the cervical plexus are established anesthetic procedures for carotid endarterectomy. This randomized, double-blind, placebo-controlled study tested the hypothesis that an additional ultrasound-guided periarterial injection of local anesthetic leads to a lower frequency of periarterial supplementation by the surgeon. METHODS: A total of 40 patients were randomly assigned to 1 of 2 groups. In both groups an ultrasound-guided intermediate cervical plexus block (20 ml of 0...
December 2016: Der Anaesthesist
https://www.readbyqxmd.com/read/27716943/paracetamol-acetaminophen-for-prevention-or-treatment-of-pain-in-newborns
#11
REVIEW
Arne Ohlsson, Prakeshkumar S Shah
BACKGROUND: Newborn infants have the ability to experience pain. Hospitalised infants are exposed to numerous painful procedures. Healthy newborns are exposed to pain if the birth process consists of assisted vaginal birth by vacuum extraction or by forceps and during blood sampling for newborn screening tests. OBJECTIVES: To determine the efficacy and safety of paracetamol for the prevention or treatment of procedural/postoperative pain or pain associated with clinical conditions in neonates...
October 7, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27665091/a-randomized-trial-on-the-efficacy-of-topical-anesthesia-for-pain-reduction-during-frame-placement-for-gamma-knife-radiosurgery
#12
Sean Michael Duenas, Jonathan Pun, Hesham A Radwan, Meredith Akerman, Michael Schulder
BACKGROUND/AIMS: Frame application for gamma knife radiosurgery (GKR) may be perceived as painful by patients. This study was designed to assess the efficacy of EMLA (2.5% lidocaine/2.5% prilocaine) in pain reduction. METHODS: This was a prospective, randomized, and controlled trial approved by our institutional review board. Fifty-four patients undergoing outpatient GKR were divided into EMLA and placebo groups. Prior to frame placement, EMLA/placebo was applied to the patient's forehead...
September 24, 2016: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/27637996/-neuraxial-anesthesia-after-local-anesthesia-for-management-of-percutaneous-vertebroplasty-complication-during-vertebroplasty
#13
Hüseyin Balkarlı, Mesut Kılıç, İbrahim Öztürk
Percutaneous vertebroplasty is a relatively safe, simple and commonly performed interventional procedure for the management of vertebral compression fractures. However, serious complications are rarely reported in the procedure. Those are pulmonary embolism, severe infection, paraplegia and an occurrence of a new fracture in an adjacent vertebra after vertebroplasty. Acute complications are generally associated with the procedure. We present the case of neuraxial anesthesia, developed after local anesthesia with 8mL of 2% prilocaine, in a 68-year-old woman who underwent percutaneous vertebroplasty after an osteoporotic collapsed fracture in the L1 vertebra due to trauma...
September 13, 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/27617615/effective-local-anesthesia-for-onabotulinumtoxin-a-injections-to-treat-hyperhidrosis-associated-with-traumatic-amputation
#14
Lucy L Shi, Michael R Sargen, Suephy C Chen, Jack L Arbiser, Brian P Pollack
BACKGROUND: Botulinum toxin type A (BTX-A) injections are an effective treatment for controlling hyperhidrosis at sites of amputation. Hyperesthesia associated with amputated limbs is a major barrier to performing this procedure under local anesthesia. OBJECTIVE: To present a novel method for improving local anesthesia with BTX-A injections. Methods & RESULTS: A 29-year-old military veteran with a below-the-knee amputation of his right leg was suffering from amputation site hyperhidrosis, which was impeding his ability to comfortably wear a prosthesis...
June 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27595728/effect-of-topical-anesthesia-with-lidocaine-prilocaine-emla-cream-and-local-pressure-on-pain-during-infiltration-injection-for-maxillary-canines-a-randomized-double-blind-clinical-trial
#15
Amin S Milani, Vahid Zand, Amir A Abdollahi, Mohammad Froughreyhani, Parvin Zakeri-Milani, Mohammad A Jafarabadi
OBJECTIVES: This study compared the effect of local pressure and topical lidocaine-prilocaine (EMLA) cream on pain during infiltration injection for maxillary canine teeth. MATERIALS AND METHODS: A total of 140 volunteer students participated in this split-mouth design randomized clinical trial. The subjects were randomly divided into four groups (n = 35). Before administration of anesthesia, in each group, one side was randomly selected as the experimental and the opposite side as the control...
July 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27595402/a-novel-pain-alternative-for-patients-with-anorectal-pathologies-the-comparison-of-transperineal-prostatic-blockage-technique-with-periprostatic-nerve-blockage-and-rectal-gel-technique-in-initial-transrectal-ultrasound-guided-prostate-biopsy-a-prospective-randomized
#16
Deniz Bolat, Tansu Degirmenci, Bulent Gunlusoy, Erhan Aydin, Ozgu Aydogdu, Yasin Ceylan
INTRODUCTION: The study aimed to compare the efficiency of periprostatic nerve blockage (PPNB) and intrarectal lidocaine gel (PPNB + gel) with a transperineal prostatic block (TPPB) technique during transrectal ultrasound-guided prostate biopsy (TRUS-PBx) in patients with anorectal pathologies. MATERIALS AND METHODS: A total of 376 patients who underwent TRUS-PBx were randomized into 2 groups. Group-I (n = 198) received TPPB with 10 ml 2% prilocaine, and group-II (n = 178) received intrarectal administration of 10 ml 2% lidocaine gel followed by PPNB with 10 ml 2% prilocaine...
2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27592116/local-anesthetics-affect-gramicidin-a-channels-via-membrane-electrostatic-potentials
#17
Svetlana S Efimova, Anastasiia A Zakharova, Ludmila V Schagina, Olga S Ostroumova
The effects of local anesthetics (LAs), including aminoamides and aminoesters, on the characteristics of single gramicidin A (GA) channels in 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) bilayers were studied. Aminoamides, namely lidocaine (LDC), prilocaine (PLC), mepivacaine (MPV), and bupivacaine (BPV), reduced the conductance of GA channels. Aminoesters influenced the current fluctuations induced by GA differently; procaine (PC) did not affect the fluctuations, whereas tetracaine (TTC) distinctly reduced the conductance of single GA channels...
December 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27543066/nanostructured-lipid-carriers-as-robust-systems-for-topical-lidocaine-prilocaine-release-in-dentistry
#18
Lígia N M Ribeiro, Michelle Franz-Montan, Márcia C Breitkreitz, Ana C S Alcântara, Simone R Castro, Viviane A Guilherme, Raquel M Barbosa, Eneida de Paula
In dental practice, local anesthesia causes pain, fear, and stress, and is frequently the reason that patients abandon treatment. Topical anesthetics are applied in order to minimize the discomfort caused by needle insertion and injection, and to reduce the symptoms of superficial trauma at the oral mucosa, but there are still no efficient commercially available formulations. Factorial design is a multivariate data analysis procedure that can be used to optimize the manufacturing processes of lipid nanocarriers, providing valuable information and minimizing development time...
October 10, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27500801/analgesic-efficacy-of-equimolar-50-nitrous-oxide-oxygen-gas-premix-kalinox%C3%A2-as-compared-with-a-5-eutectic-mixture-of-lidocaine-prilocaine-emla%C3%A2-in-chronic-leg-ulcer-debridement
#19
Juerg Traber, Ulrike Held, Maria Signer, Tobias Huebner, Stefan Arndt, Thomas A Neff
Chronic foot and leg ulcers are a common health problem worldwide. A mainstay of chronic ulcer therapy is sharp mechanical wound debridement requiring potent analgesia. In this prospective, controlled, single-centre, crossover design study, patients were assigned to either the administration of topical analgesia with 5% lidocaine/prilocaine cream or the inhalation of an analgesic 50% N2 O/O2 gas premix. Primary outcome parameter was level of pain at maximum wound depth during debridement as measured by a visual analogue scale...
August 8, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27480118/in-vitro-and-in-vivo-evaluation-of-new-topical-anaesthetic-cream-formulated-with-palm-oil-base
#20
Sitti Nor Khamdiah Khodari, Zamri Chik, Mohamed Ibrahim Noordin, Lucy Chan
BACKGROUND: Topical local anaesthetic cream was reported to be useful for pain relief for cutaneous procedures such as minor surgery and venipuncture. OBJECTIVE: The aim of this study was to evaluate the effectiveness of new formulation of lidocaine topical anaesthetic using palm oil base, HAMIN® and to determine how fast this new formulation produces adequate numbness compared to the currently used EMLA cream, in the University of Malaya Medical Centre (UMMC) set-up...
August 1, 2016: Current Drug Delivery
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