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Prilocaine

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https://www.readbyqxmd.com/read/29119061/emla-anaesthetic-cream-for-debridement-of-burns-a-study-of-plasma-concentrations-of-lidocaine-and-prilocaine-and-a-review-of-the-literature
#1
Stefan Lillieborg, Leif Aanderud
The lidocaine-prilocaine cream (EMLA(TM)) effectively reduces the pain from debridement of chronic leg ulcers. Studies have demonstrated that when applied to leg ulcers, plasma concentrations of the local anaesthetics are well below the threshold for CNS toxicity. However, there are minimal pharmacokinetic data available from EMLA application to burn wounds. This study evaluated EMLA cream for debridement of burns with regard to plasma concentrations of lidocaine and prilocaine, and reviewed the published literature on safety and efficacy of lidocaine-prilocaine applied epicutaneously to burns...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/29075099/design-and-evaluation-of-lidocaine-and-prilocaine-coloaded-nanoparticulate-drug-delivery-systems-for-topical-anesthetic-analgesic-therapy-a-comparison-between-solid-lipid-nanoparticles-and-nanostructured-lipid-carriers
#2
Peijun You, Ran Yuan, Chuanyu Chen
PURPOSE: Topical anesthesia analgesic therapy has diverse applicability in solving the barrier properties of skin and unfavorable physicochemical properties of drugs. Lidocaine (LID) combined with prilocaine (PRI) has been used as a topical preparation for dermal anesthesia for treatment of conditions such as paresthesia. MATERIALS AND METHODS: In this study, for combination anesthesia and overcoming the drawbacks of LID and PRI, respectively, LID- and PRI-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were prepared and characterized by determination of their particle size, drug loading capacity, stability, in vitro drug release behavior and in vitro cellular viability...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29069016/topical-cryoanesthesia-for-the-relief-of-pain-caused-by-steroid-injections-used-to-treat-hypertrophic-scars-and-keloids
#3
RANDOMIZED CONTROLLED TRIAL
Xiuxia Wang, Xiaoli Wu, Ke Liu, Lingling Xia, Xunxun Lin, Wei Liu, Zhen Gao
Intralesional steroid injections are the standard treatment for hypertrophic scars and keloids. The procedure is, however, quite painful and is unpopular with patients because of this. Topical application of anesthetic creams, such as Ametop gel (tetracaine) and EMLA cream (lidocaine and prilocaine), has limited efficacy because of poor drug penetration. The onset of the analgesic effect is also slow, which means that the use of topical anesthetics is time-consuming in clinical practice.We hypothesized that a commercially available cryotip could be used to provide fast-acting topical cryoanesthesia that would reduce the pain associated with steroid injections...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28974451/combining-amino-amide-salts-in-mucoadhesive-films-enhances-needle-free-buccal-anesthesia-in-adults
#4
Renê Oliveira do Couto, Camila Cubayachi, Paulo Linares Calefi, Renata Fonseca Vianna Lopez, Vinícius Pedrazzi, Cristiane Masetto De Gaitani, Osvaldo de Freitas
Needle-phobia is usually a great concern in dentistry, and the replacement of painful injections by patient-friendly needle-free topical formulations would bring several advantages in dental practice worldwide. In this pursuit, the effects of combining prilocaine hydrochloride (PCL) and lidocaine hydrochloride (LCL) in different proportions in mucoadhesive films on their in vitro permeation and retention through porcine esophageal mucosa was studied. Complementarily, the permeation and retention of isolated LCL was investigated...
September 30, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28971170/comparison-of-riva-and-infraclavicular-block-in-forearm-and-hand-surgery
#5
Zubeyir Sivrikaya, Guldem Turan, Reyhan Cetiner, Dilek Subasi, Gulcin Ozturk, Asu Ozgultekin, Osman Ekinci
OBJECTIVE: The aim of this study was to compare 2 techniques that are widely used in hand, wrist, and forearm: regional intravenous anesthesia (RIVA) and infraclavicular brachial block. METHODS: A total of 100 patients who were aged 18 to 85 years and who underwent hand, wrist, or forearm surgery of at least 30 minutes duration were included. RIVA was applied to Group 1 patients with administration of 40 mL of prilocaine (3 mg/kg). Ultrasonography-guided infraclavicular block was performed on Group 2 patients with 20 mL of 1% prilocaine...
2017: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/28903852/prilocaine-induced-methemoglobinemia
#6
Harun Gunes, Feruza Turan Sonmez, Fatih Guneysu, Hayati Kandis, Ayhan Saritas
No abstract text is available yet for this article.
August 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28902650/a-rare-cause-of-cyanosis-and-hypoxia-that-should-not-be-forgotten-after-implantable-cardioverter-defibrillator-implantation
#7
Uğur Canpolat, Nihan Bahadır, Levent Şahiner, Kudret Aytemir
Transvenous pacemaker or implantable cardioverter defibrillator (ICD) implantation procedures are usually performed under local anesthetic, and prilocaine is the most common agent to be used. The data regarding methemoglobinemia after cardiac device implantation are scarce. Thus, presently described is the case of a 47-year-old female patient with arrhythmogenic right ventricular cardiomyopathy/dysplasia who underwent ICD implantation for secondary prophylaxis and developed cyanosis as a result of prilocaine-associated methemoglobinemia...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28803262/topic-anaesthesia-with-a-eutectic-mixture-of-lidocaine-prilocaine-cream-after-elective-caesarean-section-a-randomised-placebo-controlled-trial
#8
Thomas Grosse-Steffen, Malin Krämer, Benjamin Tuschy, Christel Weiss, Marc Sütterlin, Sebastian Berlit
PURPOSE: Aim of the study was to investigate the topical application of a eutectic mixture of lidocaine/prilocaine (EMLA(®)) cream after caesarean section (CS) and its effect on postoperative pain, time to mobilisation, and time to discharge. MATERIALS AND METHODS: A total of 189 pregnant women were enrolled; full data sets were available for 139 of them, who were prospectively randomised to receive either placebo (control group) or EMLA(®) cream (study group) on the CS lesion directly as well as 24 h after surgery...
October 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28681498/tumescent-local-anaesthesia-for-early-dermatosurgery-in-infants
#9
M Heister, H M Häfner, H Breuninger, C Schulz, K Meier, L Kofler, C Spott, M Röcken, S M Schnabl, F C Eberle
BACKGROUND: Early paediatric dermatosurgery reveals excellent cosmetic results due to high skin-elasticity and pronounced capacity to recover from trauma. Furthermore, the size of skin lesions increases during life proportionally to skin growth and therefore early removal is of major importance. Selected local anaesthetics like prilocaine can cause methaemoglobinemia. However, in contrast to general anaesthesia many other local anaesthetics do not bare any major risks for infants. OBJECTIVE: In this retrospective study, we analysed infants aged less than 7 months receiving tumescent local anaesthesia (TLA) followed by dermatosurgery at our department between 2005 and 2015...
July 6, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28653424/anesthetic-ointment-only-lidocaine-prilocaine-instead-of-injectable-local-lidocaine-in-trans-radial-catheterization-a-viable-no-needle-alternative
#10
George Latsios, Kostas Toutouzas, Alexios S Antonopoulos, Eleni Melidi, Andreas Synetos, Georgia Vogiatzi, Aggeliki Stasinopoulou, Kostas Tsioufis, Eleftherios Tsiamis, Dimitrios Tousoulis
OBJECTIVE: The aim of the present study was to assess the level of access site pain in patients undergoing transradial coronary catheterization by using topical application of an anesthetic ointment (lidocaine/prilocaine-AO) compared to standard local anesthesia (LA) by means of injectable lidocaine. METHODS: We prospectively studied 444 patients undergoing elective trans-radial coronary angiography. The quality of analgesia was assessed using a visual analogue scale (VAS) immediately after the puncture and 30 min after the removal of the sheath...
August 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28650749/comparative-effectiveness-of-radial-extracorporeal-shockwave-therapy-and-ultrasound-guided-local-corticosteroid-injection-treatment-for-plantar-fasciitis
#11
Sehriban Hocaoglu, Umit Erkan Vurdem, Mehtap Aykac Cebicci, Serap Tomruk Sutbeyaz, Zuhal Guldeste, Serap Gurek Yunsuroglu
BACKGROUND: We compared the long-term clinical and ultrasonographic effects of radial extracorporeal shockwave therapy (rESWT) versus ultrasound-guided corticosteroid injection treatment in patients with plantar fasciitis unresponsive to conservative therapy. METHODS: Seventy-two patients with unilateral plantar fasciitis were randomized to receive either rESWT (three times once per week) (n = 36) or corticosteroid treatment (a single 1-mL dose of betamethasone sodium plus 0...
May 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28594757/anesthetic-cream-use-during-office-pessary-removal-and-replacement-a-randomized-controlled-trial
#12
RANDOMIZED CONTROLLED TRIAL
Susanne K Taege, William Adams, Elizabeth R Mueller, Linda Brubaker, Colleen M Fitzgerald, Cynthia Brincat
OBJECTIVE: To estimate the effect of lidocaine-prilocaine cream on patient pain at the time of office pessary removal and reinsertion. METHODS: In this double-blind, randomized placebo-controlled trial, participants undergoing routine pessary care in a urogynecology office at a tertiary referral center were randomized to application of 4 g of either lidocaine-prilocaine or placebo cream 5 minutes before pessary change. Visual analog scale pain scores were collected from the patient at baseline, after pessary removal, and after pessary reinsertion...
July 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28580612/utility-of-basophil-activation-testing-to-assess-perioperative-anaphylactic-reactions-in-real-world-practice
#13
Bernadette Eberlein, Sibylle Wigand, Heidrun Lewald, Eberhard Kochs, Johannes Ring, Tilo Biedermann, Ulf Darsow
INTRODUCTION: Perioperative anaphylactic reactions due to drugs and substances associated with general anesthesia can potentially be life-threatening. The objective of this study was to investigate the significance of the basophil activation test (BAT) for allergy diagnosis work up. METHODS: A total of 14 patients (5 men, 9 women; mean age: 57.8 years) with clinical records of anaphylactic reactions under general anesthesia were studied by means of anesthesia records, skin and serological tests...
June 5, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28551190/clinical-trial-of-local-anesthetic-protocols-for-acute-pain-associated-with-caustic-paste-disbudding-in-dairy-calves
#14
Charlotte B Winder, Stephen J LeBlanc, Derek B Haley, Kerry D Lissemore, M Ann Godkin, Todd F Duffield
Caustic paste disbudding is becoming more commonplace in North America. A large body of work has examined pain control for cautery disbudding and surgical dehorning, but fewer studies have evaluated pain control for caustic paste disbudding, and results conflict regarding benefits of local anesthesia. In humans, the pain associated with a caustic, chemical burn can differ in nature, duration, and intensity compared with a thermal burn. The objective of this clinical trial was to evaluate the effects of either a lidocaine cornual nerve block or a topical anesthetic incorporated into caustic paste on the acute pain of caustic paste disbudding...
May 24, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28546768/effectiveness-of-various-formulations-of-local-anesthetics-and-additives-for-topical-anesthesia-a-prospective-randomized-double-blind-placebo-controlled-study
#15
Christian Weilbach, Christian Hoppe, Matthias Karst, Michael Winterhalter, Konstantinos Raymondos, Arthur Schultz, Niels Rahe-Meyer
BACKGROUND: Topical anesthesia is used to control pain associated with many procedures in medicine. Today, the product most commonly applied for topical anesthesia in Germany is EMLA(®) (lidocaine/prilocaine). However, since prilocaine is a methemoglobin-inducing agent, there are limitations to its use, especially in neonates and infants. The aim of this study was to evaluate the effect of prilocaine and lidocaine as well as propylene glycol, a penetration enhancer, and trometamol, a buffer substance, in anesthetic creams...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28480792/a-rare-presentation-of-meralgia-paraesthetica-in-limb-girdle-muscular-dystrophy
#16
Ozgur Zeliha Karaahmet, Eda Gurcay, Duygu Ozturk, Sukran Guzel, Aytul Cakci
A 44-year-old female with paraesthesia and pain on the left anterolateral thigh who had been diagnosed with limb-girdle muscular dystrophy by electromyography and muscle biopsy is presented. Neurological examination revealed atrophy of the proximal muscles of both shoulders, plus pseudo hypertrophy of both calves. Electromyography exhibited a myopathic pattern. Musculoskeletal ultrasound imaging demonstrated a fusiform nerve swelling below the inguinal ligament suggesting lateral femoral cutaneous nerve compression, consistent with meralgia paraesthetica...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/28474037/on-the-structure-of-prilocaine-in-aqueous-and-amphiphilic-solutions
#17
Alvaro Silva-Santisteban, Nicola Steinke, Andrew J Johnston, Guadalupe N Ruiz, Luis Carlos Pardo, Sylvia E McLain
The solvation of prilocaine has been investigated in pure water and in an amphiphilic methanol/water solution using a combination of neutron diffraction with isotopic substitution augmented by Empirical Potential Structure Refinement (EPSR) simulations. This combination of techniques allows for details of the solvation structure on the atomic scale to be unravelled. The hydration of prilocaine is significantly altered relative to when this molecule is in pure water (as a hydrochloride salt) or in an amphiphilic environment (as a freebase compound)...
May 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28408851/prilocaine-hydrochloride-2-hyperbaric-solution-for-intrathecal-injection-a-clinical-review
#18
REVIEW
Alberto Manassero, Andrea Fanelli
Prilocaine is a local anesthetic characterized by intermediate potency and duration and fast onset of action. As hyperbaric formulation of 5% solution, it was introduced and has been successfully used for spinal anesthesia since 1960. A new formulation of 2% plain and hyperbaric solution is currently available in Europe. Because of its lower incidence of transient neurological symptoms, prilocaine is suggested as substitute to lidocaine and mepivacaine in spinal anesthesia for ambulatory surgery, as well as a suitable alternative to low doses of long-acting local anesthetics...
2017: Local and Regional Anesthesia
https://www.readbyqxmd.com/read/28408390/lidocaine-prilocaine-spray-for-premature-ejaculation
#19
(no author information available yet)
Although premature ejaculation is the most common ejaculation problem, it is poorly understood and currently has no standard definition.(1) Typically, it involves reduced time to ejaculation, inability to control or delay ejaculation and associated distress.(1-5) Treatments that have been assessed include psychosexual counselling, antidepressants (e.g. selective serotonin reuptake inhibitors), phosphodiesterase type-5 inhibitors, tramadol and topical anaesthetic agents (e.g. lidocaine/prilocaine cream). A new formulation (cutaneous spray) of lidocaine/prilocaine (Fortacin-Plethora Solutions Ltd...
April 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28383414/lidocaine-prilocaine-cream-reduces-catheter-related-bladder-discomfort-in-male-patients-during-the-general-anesthesia-recovery-period-a-prospective-randomized-case-control-strobe-study
#20
RANDOMIZED CONTROLLED TRIAL
Li Mu, Li-Cheng Geng, Hui Xu, Man Luo, Jing-Miao Geng, Li Li
Urethral catheterization is a predictor of agitation during the general anesthesia recovery period. The aim of this study was to determine the effect of intraurethral 5% lidocaine and 25 mg/g prilocaine cream in reducing catheter-related bladder discomfort (CRBD) in male patients during the general anesthesia recovery period. Adult male patients undergoing elective operations that required urinary catheterization under general anesthesia were enrolled and assigned randomly to 2 groups. In the lidocaine-prilocaine cream group (n = 72), approximately 5 g of topical cream was spread in the preputial sac, the glans, the meatus, and on the urinary catheter surface before urinary catheterization...
April 2017: Medicine (Baltimore)
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