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https://www.readbyqxmd.com/read/28943040/treatment-of-musculo-skeletal-pain-in-haemophilia
#1
REVIEW
E Carlos Rodriguez-Merchan
Musculo-skeletal pain treatment is inadequate in many haemophilic patients. Analgesics are used only by 36% of adult patients. FVIII/FIX intravenous infusion is mainly used to lessen pain, followed in frequency by usage of NSAIDS (primarily COX-2 inhibitors). In about 30% of patients, pain continues after infusion of F VIII/IX. In acute haemarthroses pain treatment must continue until total disappearance (checked by ultrasonography) and include haematologic treatment, short-term rest of the involved joint, cryotherapy, joint aspiration and analgesic medication (paracetamol in mild pain, metamizole for more intense pain, and in a few precise patients, soft opioids such as codeine or tramadol)...
September 19, 2017: Blood Reviews
https://www.readbyqxmd.com/read/28941045/transthyretin-deposition-promotes-progression-of-osteoarthritis
#2
Tokio Matsuzaki, Yukio Akasaki, Merissa Olmer, Oscar Alvarez-Garcia, Natalia Reixach, Joel N Buxbaum, Martin K Lotz
Deposition of amyloid is a common aging-associated phenomenon in several aging-related diseases. Osteoarthritis (OA) is the most prevalent joint disease, and aging is its major risk factor. Transthyretin (TTR) is an amyloidogenic protein that is deposited in aging and OA-affected human cartilage and promotes inflammatory and catabolic responses in cultured chondrocytes. Here, we investigated the role of TTR in vivo using transgenic mice overexpressing wild-type human TTR (hTTR-TG). Although TTR protein was detected in cartilage in hTTR-TG mice, the TTR transgene was highly overexpressed in liver, but not in chondrocytes...
September 22, 2017: Aging Cell
https://www.readbyqxmd.com/read/28937534/the-spread-of-ultrasound-guided-injectate-from-the-adductor-canal-to-the-genicular-branch-of-the-posterior-obturator-nerve-and-the-popliteal-plexus-a-cadaveric-study
#3
Charlotte Runge, Bernhard Moriggl, Jens Børglum, Thomas Fichtner Bendtsen
BACKGROUND AND OBJECTIVES: The popliteal nerve plexus contributes to afferent knee-pain conduction. It is mainly formed by genicular branches from the posterior obturator and the tibial nerves, innervating the intra-articular and posterior knee region. A subinguinal obturator nerve block alleviates pain after total knee arthroplasty. Reduced hip adductor motor function could be avoided by a posterior obturator nerve block inside the popliteal fossa. The aim of this study was to evaluate the spread of dye after a distal adductor canal (AC) injection to the popliteal fossa and coloring of the popliteal plexus and the genicular branch of the posterior obturator nerve by dissection...
September 20, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28934876/comparison-of-intra-articular-injection-of-hyaluronic-acid-and-n-acetyl-cysteine-in-the-treatment-of-knee-osteoarthritis-a-pilot-study
#4
Mustafa Ozcamdalli, Abdulhamit Misir, Turan Bilge Kizkapan, Erdal Uzun, Fuat Duygulu, Cevat Yazici, Ibrahim Halil Kafadar
Objective To compare the relative effectiveness of intra-articular N-acetyl cysteine (NAC) and hyaluronic acid (HA) on pain, function and cartilage degradation markers in patients with mild to moderate knee osteoarthritis (OA). Design We prospectively conducted a clinical trial with 20 patients having a diagnosis of Kellgren-Lawrence grade 2-3 knee OA, and randomly allocated to the HA or NAC groups. Groups were matched on age, sex, and body mass index. Injections of 3-mL HA (Hylan G-F 20) or 3-mL NAC (Asist ampoule) were administered as a single shot...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28928049/role-for-cementoplasty-in-intra-articular-distal-radius-fractures-cadaver-study-and-application-to-arthroscopy
#5
V Fontaine, M Grunberg, J Soret, K El-Youssef, L E Gayet, R Taberne
BACKGROUND: Die-punch intra-articular fractures of the distal radius raise surgical challenges. The residual articular step-off must be less than 1mm to prevent the development of radio-carpal osteoarthritis. The objectives of this cadaver study were to evaluate whether cementoplasty was effective in reducing die-punch fractures and to determine whether this technique was feasible as an arthroscopic procedure. HYPOTHESIS: Cementoplasty performed as an arthroscopic procedure is effective in treating die-punch fractures...
September 16, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28910961/paeonol-alleviates-interleukin-1%C3%AE-induced-inflammatory-responses-in-chondrocytes-during-osteoarthritis
#6
Mingran Liu, Shuqiang Zhong, Ruifeng Kong, Hong Shao, Chunyan Wang, Hongying Piao, Wentao Lv, Xiaojie Chu, Yan Zhao
Interleukin-1β (IL-1β)-induced inflammatory responses in chondrocytes play an important role in the pathogenesis of osteoarthritis (OA). Searching medicines that affect IL-1β-mediated chondrocytes function is critical in developing therapies for OA. Paeonol, as an important component in traditional Chinese medicine, has anti-inflammatory activity and can offer therapy for a multitude of inflammatory-related diseases. The purpose of this study was to investigate whether paeonol could alleviate the progression of OA through inhibition of IL-1β-induced inflammatory responses in chondrocytes...
September 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28902756/sacroiliac-joint-dysfunction-in-the-athlete-diagnosis-and-management
#7
Rebecca Peebles, Christopher E Jonas
Sacroiliac joint (SIJ) dysfunction is a common cause of low back pain in the athlete, especially in sports with repetitive, asymmetric loading. Complex anatomy and broad pain referral pattern make diagnosis difficult. Identifying three or more positive physical examination maneuvers for the SIJ improves examination sensitivity and specificity. Imaging is rarely helpful in establishing the diagnosis but is often used to rule out other pathology. Conservative management with activity modification, medication, physical therapy, manipulation and bracing is first line treatment...
September 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28902105/clinical-effectiveness-of-intra-articular-pulsed-radiofrequency-compared-to-intra-articular-corticosteroid-injection-for-management-of-atlanto-occipital-joint-pain-a-prospective-randomized-controlled-pilot-study
#8
So Min Shin, Sang Gyu Kwak, Dong Gyu Lee, Min Cheol Chang
STUDY DESIGN: A prospective randomized controlled pilot study OBJECTIVE.: We aimed to assess the effectiveness of pulsed radiofrequency (PRF) stimulation on the atlanto-occipital (AO) joint in patients with chronic joint pain. Additionally, we compared the effects of AO intra-articular (IA) PRF and AO IA corticosteroid. SUMMARY OF BACKGROUND DATA: IA injection of corticosteroids into the AO joint is widely used for the management of head and upper cervical pain, and its effectiveness has been shown in previous studies...
September 8, 2017: Spine
https://www.readbyqxmd.com/read/28899826/comparative-efficacy-of-intra-articular-steroid-injection-and-distension-in-patients-with-frozen-shoulder-a-systematic-review-and-network-meta-analysis
#9
REVIEW
Meng-Ting Lin, Ming-Yen Hsiao, Yu-Kang Tu, Tyng-Guey Wang
OBJECTIVE: To compare the efficacy of intra-articular (IA) steroid injection and distension in patients with frozen shoulder. DATA SOURCES: Databases, including MEDLINE (via PubMed), EMBASE, Scopus and Cochrane Library, were searched for studies published up to November 2016. STUDY SELECTION: We included all published randomized controlled trials (RCTs), quasi-experimental studies and observational studies investigating the effectiveness of IA steroid injection, distension and physiotherapy in patients with frozen shoulder...
September 9, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28892260/synthetic-poly-vinylalcohol-based-membranes-for-cartilage-surgery-and-repair
#10
Benjamin C U Tai, Chan Du, Shujun Gao, Andrew C A Wan
Cell-based therapies for cartilage repair are continually being developed to treat osteoarthritis. The cells are either introduced directly by intra-articular injection or via a cell-seeded matrix scaffold. Here, poly(vinylalcohol)-based membranes are developed to be used for mesenchymal stem cell implantation in cartilage repair procedures, having controllable physicochemical properties such as porosity, mechanical strength, and permeability, and a unique self-sealing property. The membranes possess a bilayer structure with a less porous layer providing mechanical strength and selective permeability, exhibit an elastic modulus of between 0...
September 11, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28888902/a-small-molecule-inhibitor-of-the-wnt-pathway-sm04690-as-a-potential-disease-modifying-agent-for-the-treatment-of-osteoarthritis-of-the-knee
#11
V Deshmukh, H Hu, C Barroga, C Bossard, S Kc, L Dellamary, J Stewart, K Chiu, M Ibanez, M Pedraza, T Seo, L Do, S Cho, J Cahiwat, B Tam, J R S Tambiah, J Hood, N E Lane, Y Yazici
OBJECTIVES: Osteoarthritis (OA) is a degenerative disease characterized by loss of cartilage and increased subchondral bone within synovial joints. Wnt signaling affects the pathogenesis of OA as this pathway modulates both the differentiation of osteoblasts and chondrocytes, and production of catabolic proteases. A novel small-molecule Wnt pathway inhibitor, SM04690, was evaluated in a series of in vitro and in vivo animal studies to determine its effects on chondrogenesis, cartilage protection and synovial-lined joint pathology...
September 6, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28885454/attenuation-of-early-phase-inflammation-by-cannabidiol-prevents-pain-and-nerve-damage-in-rat-osteoarthritis
#12
Holly T Philpott, Melissa O'Brien, Jason J McDougall
Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration, intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a non-euphoria producing constituent of cannabis that has the potential to relieve pain. The aim of this study was to determine if CBD is anti-nociceptive in OA, and whether inhibition of inflammation by CBD could prevent the development of OA pain and joint neuropathy. OA was induced in male Wistar rats (150-175g) by intra-articular injection of sodium monoiodoacetate (MIA; 3mg)...
September 1, 2017: Pain
https://www.readbyqxmd.com/read/28882752/mechanosensitive-ion-channels-msics-in-articular-nociceptors-drive%C3%A2-mechanical-allodynia-in-osteoarthritis-oa
#13
B H He, M Christin, S Mouchbahani-Constance, A Davidova, R Sharif-Naeini
OBJECTIVE: Osteoarthritis (OA) is a disabling and highly prevalent condition affecting millions worldwide. Pain is the major complaint of OA patients and is presently inadequately managed. It manifests as mechanical allodynia, a painful response to innocuous stimuli such as joint movement. Allodynia is due in part to the sensitization of articular nociceptors to mechanical stimuli. These nociceptors respond to noxious mechanical stimuli applied to their terminals via the expression of depolarizing high-threshold mechanosensitive ion channels (MSICs) that convert painful mechanical forces into electrical signals...
September 5, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28874727/effectiveness-of-glenohumeral-joint-dilatation-for-treatment-of-frozen-shoulder-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#14
Wei-Ting Wu, Ke-Vin Chang, Der-Sheng Han, Chung-Hsun Chang, Fu-Sui Yang, Chih-Peng Lin
The objective was to explore the effectiveness of glenohumeral joint distension for the treatment of frozen shoulder. We searched electronic data sources including PubMed, Scopus, and Embase from the earliest records available to February 2017. Eleven randomized controlled trials including at least one pair of comparisons between capsular distension and a reference treatment were included, comprising 747 participants. Patients' characteristics, details of reference treatments, aspects of capsular distension therapy, and outcome measurement were evaluated at three points in time: baseline, early following intervention, and at the trial's end...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28871338/comparison-of-the-effectiveness-on-intra-articular-and-subcutaneous-tnf-inhibitor-in-rheumatoid-arthritis-patients
#15
Fangze Zhang, Cuili Ma
The objective of this study is to evaluate the efficacy of single intra-articular (IA) injection of tumor necrosis factor α (TNFα) inhibitor in knee joints comparing with subcutaneous injection in rheumatoid arthritis (RA) patients. Forty-eight RA patients with 73 knee arthritis were divided into three groups, group A: received a single injection of TNF inhibitor into knee joints; group B: received regular subcutaneous injection; and group C: received both of the regimen as groups A and B. Ultrasound, erythrocyte sedimentation rate, C-reactive protein (CRP), patients' global visual analogue scale (VAS), and 28-joint Disease Activity Score (DAS28) were collected pre- and post-therapy 4 weeks...
September 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28870302/perioperative-pain-management-in-hip-and-knee-arthroplasty
#16
REVIEW
Christian J Gaffney, Christopher E Pelt, Jeremy M Gililland, Christopher L Peters
Total hip and knee arthroplasty is associated with significant perioperative pain, which can adversely affect recovery by increasing risk of complications, length of stay, and cost. Historically, opioids were the mainstay of perioperative pain control. However, opioids are associated with significant downsides. Preemptive use of a multimodal pain management approach has become the standard of care to manage pain after hip and knee arthroplasty. Multimodal pain management uses oral medicines, peripheral nerve blocks, intra-articular injections, and other tools to reduce the need for opioids...
October 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28866348/the-effect-of-intra-articular-cocktail-versus-femoral-nerve-block-for-patients-undergoing-hip-arthroscopy
#17
Sean Childs, Sonia Pyne, Kiritpaul Nandra, Wajeeh Bakhsh, S Atif Mustafa, Brian D Giordano
PURPOSE: To compare clinical efficacy and complication rate as measured by postoperative falls and development of peripheral neuritis between intra-articular blockade and femoral nerve block in patients undergoing arthroscopic hip surgery. METHODS: An institutional review board approved retrospective review was conducted on a consecutive series of patients who underwent elective arthroscopic hip surgery by a single surgeon, between November 2013 and April 2015. Subjects were stratified into 2 groups: patients who received a preoperative femoral nerve block for perioperative pain control, and patients who received an intra-articular "cocktail" injection postoperatively...
August 30, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28866048/subcutaneous-lipoatrophy-and-skin-depigmentation-secondary-to-tmj-intra-articular-corticosteroid-injection
#18
Nicolás Patricio Skármeta, Fernando Ariel Hormazábal, Juan Alvarado, Ana Maria Rodriguez
Chronic orofacial pain is a complex multidimensional experience that produces disability and impairment of normal mandibular function. Overall estimations of chronic orofacial pain prevalence are 7 to 11% of the general population. Temporomandibular disorders (TMDs) are one of the most prevalent chronic orofacial pain conditions, with temporomandibular joint (TMJ) arthralgia accounted for 30.1% of TMD patients. Interventional procedures are often used in pain and palliative medicine to achieve reasonable and cost-effective pain relief...
August 5, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28861195/india-based-knee-osteoarthritis-evaluation-ikare-a-multi-centre-cross-sectional-study-on-the-management-of-knee-pain-and-early-osteoarthritis-in-india
#19
Parag Sancheti, Vijay D Shetty, Mandeep S Dhillon, Sheila A Sprague, Mohit Bhandari
BACKGROUND: Access to early knee osteoarthritis treatment in low and middle income nations is often believed to be limited. We conducted a cross-sectional study in India to assess prior access to treatment among patients presenting with knee pain to specialist orthopaedic clinics. METHODS: The multi-centre, cross-sectional study included patients presenting with knee pain at 3 hospitals in India. Patients who met the inclusion criteria and provided informed consent completed a questionnaire designed to assess patient demographics, socioeconomic status, knee pain, treatment method, and patient's knowledge on osteoarthritis (OA)...
September 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28860852/expression-of-matrix-metalloproteinases-and-components-of-the-endocannabinoid-system-in-the-knee-joint-are-associated-with-biphasic-pain-progression-in-a-rat-model-of-osteoarthritis
#20
Agnieszka Pajak, Magdalena Kostrzewa, Natalia Malek, Michal Korostynski, Katarzyna Starowicz
Matrix metalloproteinases (MMPs) are considered important in articular cartilage breakdown during osteoarthritis (OA). Similarly, the endocannabinoid system (ECS) is implicated in joint function and modulation of nociceptive processing. Functional interplay between ECS and MMPs has been recently indicated. Here, we tested if changes in the expression of selected MMPs and major ECS elements temporally correlate with the intensity of OA-related pain. Knee OA was induced in male Wistar rats by intra-articular sodium monoiodoacetate injection...
2017: Journal of Pain Research
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