Margarita Bartish, Dongmei Tong, Yangxun Pan, Majken Wallerius, Hui Liu, Johannes Ristau, Sabrina de Souza Ferreira, Tatjana Wallmann, Vincent van Hoef, Laia Masvidal, Thomas Kerzel, Anne-Laure Joly, Christophe Goncalves, Samuel E J Preston, Talin Ebrahimian, Christina Seitz, Jonas Bergh, Kristian Pietras, Stephanie Lehoux, Luigi Naldini, John Andersson, Mario Leonardo Squadrito, Sonia V Del Rincón, Ola Larsson, Charlotte Rolny
Tumor-associated macrophages (TAMs) continuously fine tune their immune modulatory properties, but how gene expression programs coordinate this immune cell plasticity is largely unknown. Selective mRNA translation, controlled by MNK1/MNK2 and mTOR pathways impinging on eIF4E, facilitates reshaping of proteomes without changes in abundance of corresponding mRNAs. Using polysome profiling developed for small samples we show that, during tumor growth, gene expression in TAMs is predominately modulated via mRNA-selective changes in translational efficiencies...
November 3, 2020: Proceedings of the National Academy of Sciences of the United States of America