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https://www.readbyqxmd.com/read/28719899/the-relationship-between-mmp-2-1306c-t-and-mmp-9-1562c-t-polymorphisms-and-the-risk-and-prognosis-of-t-cell-acute-lymphoblastic-leukemia-in-a-chinese-population-a-case-control-study
#1
Cong-Meng Lin, Yan-Ling Zeng, Min Xiao, Xu-Qiao Mei, Lv-Ying Shen, Meng-Xian Guo, Zhe-Yao Lin, Qi-Fa Liu, Tin Yang
BACKGROUND: T-cell acute lymphoblastic leukemia (T-ALL) is a malignant hematological disease and is often accompanied by a variety of genetic abnormalities. Hence, our study aims to investigate the relationship between MMP-2 -1306C>T and MMP-9 -1562C>T polymorphisms and the risk and prognosis of T-ALL. METHODS: From April 2009 to February 2011, a total of 376 T-ALL patients were chosen as the case group. Meanwhile, 352 healthy people who passed routine health examinations were selected as the control group...
July 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28719879/four-types-of-attenuation-of-phenol-and-cresols-in-microcosms-under-simulated-marine-conditions-a-kinetic-study
#2
Yuejie Wang, Fanping Meng, Yufei Lin, Weiyan Duan, Qunqun Liu
Phenol, o-cresol, m-cresol, and p-cresol were selected to conduct microcosm experiments to examine their attenuation under simulated marine conditions, aiming at estimating natural attenuation and the contribution of oxidation, photolysis, biodegradation, and volatilisation to total attenuation of phenol and three cresols in the marine environment. The development of attenuation in microcosms showed the relevance of the pseudo-first-order kinetic for all phenols. The half-lives of phenol, o-cresol, m-cresol, and p-cresol attenuation under optimal conditions were 7...
July 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28719875/novel-magnetic-carboxyl-modified-hypercrosslinked-resins-for-effective-removal-of-typical-ppcps
#3
Jing Jin, Tianyu Feng, Yan Ma, Wei Wang, Yunshu Wang, Qing Zhou, Aimin Li
A series of novel magnetic carboxyl modified hypercrosslinked resins were successfully prepared via a sequence of suspension polymerization, hydrolysis and post-crosslinking reactions. The serial resins possessed both high cation exchange capacity and high specific surface area with MA-10 having the supreme specific surface area of 1238.65 m(2)/g and MA-70 having the largest exchange capacity of 6.45 mmol/g. The serial resins exhibited excellent adsorption capacity of typical PPCPs including chloramphenicol, atenolol, ibuprofen and tetracycline, which were neutral, cationic, anionic and zwitterionic respectively in natural water...
July 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28719860/liposome-modified-titanium-surface-a-strategy-to-locally-deliver-bioactive-molecules
#4
Vincenzo De Leo, Monica Mattioli-Belmonte, Maria Teresa Cimmarusti, Annamaria Panniello, Manuela Dicarlo, Francesco Milano, Angela Agostiano, Elvira De Giglio, Lucia Catucci
Titanium and its alloys are widely employed materials for implants in orthopedic or dental surgery due to their mechanical properties, resistance to corrosion and osseointegration capability. However adverse reactions at the tissue/implant interface may occur, which limit the success of the osseointegration process. Therefore, different strategies have to be used to overcome these drawbacks. In this work, we developed two different liposome-based coatings on titanium surfaces as drug or bioactive molecule deposits for dental/orthopedic implant applications...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28719832/expression-of-myhc-isoforms-mrna-transcripts-in-different-regions-of-the-masseter-and-medial-pterygoid-muscles-in-chimpanzees
#5
Neus Ciurana, Rosa Artells, Carmen Muñoz, Júlia Arias-Martorell, Gaëlle Bello-Hellegouarch, Alejandro Pérez-Pérez, Juan Francisco Pastor, Josep Maria Potau
OBJECTIVE: The aim of this study is to examine the expression pattern of the different myosin heavy chain (MyHC) isoforms in the masseter and medial pterygoid muscles by real time quantitative polymerase chain reaction (RT-qPCR) to obtain information at molecular level which can be related to the functional characteristics of these two muscles. DESIGN: The masseter, deep and superficial portion, and medial pterygoid muscles of five adult Pan troglodytes were dissected in order to obtain samples of the anterior and posterior regions of each portion of the masseter and of the medial pterygoid...
July 9, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28719816/sulfate-radical-induced-degradation-of-%C3%AE-2-adrenoceptor-agonists-salbutamol-and-terbutaline-phenoxyl-radical-dependent-mechanisms
#6
Lei Zhou, Mohamad Sleiman, Corinne Ferronato, Jean-Marc Chovelon, Pascal de Sainte-Claire, Claire Richard
The present study investigated the reactivity and oxidation mechanisms of salbutamol (SAL) and terbutaline (TBL), two typical β2-adrenoceptor agonists, towards sulfate radical (SO4(-)) by using photo-activated persulfate (PS). The reaction pathways and mechanisms were proposed based on products identification using high resolution HPLC-ESI-MS, laser flash photolysis (LFP) and molecular orbital calculations. The results indicated that SO4(-) was the dominant reactive species in the UV/PS process. The second-order rate constants of sulfate radical reaction with SAL and TBL were measured as (3...
July 14, 2017: Water Research
https://www.readbyqxmd.com/read/28719814/enantiomeric-separation-of-seven-%C3%AE-agonists-by-nace-study-of-chiral-selectivity-with-diacetone-d-mannitol-boric-acid-complex
#7
Lili Lv, Lijuan Wang, Jun Li, Yajun Jiao, Shengnan Gao, Jiachang Wang, Hongyuan Yan
A rapid and effective nonaqueous capillary electrophoresis (NACE)-ultraviolet (UV) method was developed for the enantiomeric separation of seven β-agonists. Diacetone-d-mannitol-boric acid complex was used as a new chiral selector. It was in situ synthesized by the reaction of diacetone-d-mannitol and boric acid in methanol medium containing triethylamine. The effects of diacetone-d-mannitol, boric acid, and triethylamine concentrations on the enantioseparation were carefully investigated. Under the optimized conditions, baseline enantioseparation could be obtained for six of the tested β-agonists within 12min...
July 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28719812/the-impact-of-zno-and-tio2-on-the-stability-of-clotrimazole-under-uva-irradiation-identification-of-photocatalytic-degradation-products-and-in-vitro-cytotoxicity-assessment
#8
Agata Kryczyk, Paweł Żmudzki, Paulina Koczurkiewicz, Joanna Piotrowska, Elżbieta Pękala, Urszula Hubicka
In order to ensure the safe and effective use of pharmaceutical products especially for topical administration photostability testing is necessary. The current paper presents an in-depth analysis of the stability of one of the most common antifungal agents, namely clotrimazole. Clotrimazole has proven to be stable under UVA irradiation in applied experimental conditions, but the presence of catalysts such as ZnO and TiO2 has contributed significantly to the degradation of this compound. The findings indicate that its photocatalytic degradation reactions followed the pseudo first-order kinetics with rate constant depending on the pH and the used solvent...
June 19, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28719807/evaluation-of-a-novel-radiotracer-for-positron-emission-tomography-imaging-of-reactive-oxygen-species-in-the-central-nervous-system
#9
Alan A Wilson, Oleg Sadovski, José N Nobrega, Roger J Raymond, Francis R Bambico, Mina G Nashed, Armando Garcia, Peter M Bloomfield, Sylvain Houle, Romina Mizrahi, Junchao Tong
INTRODUCTION: Few, if any, radiotracers are available for the in vivo imaging of reactive oxygen species (ROS) in the central nervous system. ROS play a critical role in normal cell processes such as signaling and homeostasis but overproduction of ROS is implicated in several disorders. We describe here the radiosynthesis and initial ex vivo and in vivo evaluation of [(11)C]hydromethidine ([(11)C]HM) as a radiotracer to image ROS using positron emission tomography (PET). METHODS: [(11)C]HM and its deuterated isotopologue [(11)C](4) were produced using [(11)C]methyl triflate in a one-pot, two-step reaction and purified by high performance liquid chromatography...
June 1, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28719804/maternal-obesity-attenuates-predelivery-inflammatory-reaction-in-c57bl-6n-mice
#10
Sarah Appel, Merle Schulze-Edinghausen, Tobias Kretschmer, Sarah Storck, Ruth Janoschek, Inga Bae-Gartz, Marion Handwerk, Maria Wohlfarth, Kai-Dietrich Nüsken, Eva Hucklenbruch-Rother, Malte Heykants, Esther Mahabir, Jörg Dötsch
Inflammation and oxidative stress are known to increase before labour. Whether gonadal white adipose tissue (gWAT) participates in this process and whether labour-related processes in placental and adipose tissue are altered in obese women is unknown. In our mouse model, lean mice display elevated placental inflammation and oxidative stress towards the end of pregnancy, accompanied by an increased expression of pro-inflammatory factors in gWAT. Obese mice also display elevated levels of pro-inflammatory factors and oxidative stress in placentas shortly before birth...
July 1, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28719750/electrostatic-interaction-assisted-construction-of-3d-networks-of-manganese-dioxide-nanosheets-for-flexible-high-performance-solid-state-asymmetric-supercapacitors
#11
Na Liu, Yan Li Su, Zhiqiang Wang, Zhen Wang, Jinsong Xia, Yong Chen, Zhigang Zhao, Qingwen Li, Fengxia Geng
A three-dimensional (3D) macroscopic network of manganese oxide MnO2 sheets was firstly synthesized by an easily scalable solution approach, grafting the negatively charged surfaces of the MnO2 sheets with an aniline monomer by electrostatic interactions followed by a quick chemical oxidizing polymerization reaction. The obtained structure possessed MnO2 sheets interconnected with polyaniline chains, producing a 3D monolith rich of mesopores. The MnO2 sheets had almost all their reactive centers exposed on the electrode surface, combining with the electron transport highways provided by polyaniline and the shortened diffusion paths provided by the porous structure, the deliberately designed electrode achieved excellent capacitance of 762 F g-1 at a current of 1 A g-1 and cycling performance with a capacity retention of 90% over 8000 cycles...
July 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28719735/rare-earth-and-uranium-mesoionic-carbenes-a-new-class-of-f-block-carbene-complex-derived-from-an-n-heterocyclic-olefin
#12
Stephen Liddle, John Seed, Matthew Gregson, Floriana Tuna, Nicholas Chilton, Ashley Wooles, Eric McInnes
Neutral mesoionic carbenes (MICs) have emerged as an important class of carbene, however they are found only in the free form or ligated to a few d-block ions. Here, we report unprecedented f-block MIC complexes [M(N'')3{CN(Me)C(Me)N(Me)CH}] (M = U, Y, La, Nd; N'' = N(SiMe3)2). These complexes were prepared by a formal 1,4-proton migration reaction when the metal-triamides [M(N'')3] were treated with the N-heterocyclic olefin H2C=C(NMeCH)2, which constitutes a new, general way to prepare MIC complexes. Quantum chemical calculations on the 5f3 uranium(III) complex suggest the presence of a U=C donor-acceptor bond, composed of a MIC→U σ-component and a U(5f)→MIC(2p) π-back-bond, but for the d0f0 Y and La and 4f3 Nd congeners only MIC→M σ-bonding is found...
July 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28719724/synthesis-and-properties-of-new-n-heteroheptacenes-for-solution-based-organic-field-effect-transistors
#13
Fei Zhou, Sheng Liu, Bernard D Santarsiero, Donald J Wink, Damien Boudinet, Antonio Facchetti, Tom G Driver
A series of N-heteroheptacenes was synthesized from ortho-thiophene-substituted aryl azides using a Rh2(II)-catalyzed C-H bond amination reaction to construct the thienoindole moieties. This reaction tolerated the presence of electron-donating or withdrawing groups on the aryl azide without adversely affecting the yield of the amination reaction. The central thiophene ring was created from two thienoindole pieces through a Pd-catalyzed Stille reaction to install the thioether followed by a Cu-mediated Ullman reaction to trigger the cyclization...
July 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28719716/the-sophono-bone-conduction-system-surgical-audiologic-and-quality-of-life-outcomes
#14
Timothy Mclean, Irumee Pai, Andrew Philipatos, Michael Gordon
We prospectively evaluated the surgical, audiologic, and quality-of-life outcomes in 5 patients-2 men and 3 women, aged 22 to 64 years (mean: 41.8)-who were implanted with the Sophono Alpha 2 MPO Processor. The indications for implantation of this bone-conduction device included recurrent ear canal infections with hearing aids (n = 3), single-sided deafness (n = 1), and patient preference in view of difficulty using a conventional hearing aid (n = 1). In addition to the patient with single-sided deafness, 3 patients had a bilateral mixed hearing loss and 1 had a bilateral conductive hearing loss...
July 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28719648/oligo-ethylene-glycol-sidechain-microgels-prepared-in-absence-of-cross-linking-agent-polymerization-characterization-and-variation-of-particle-deformability
#15
Nicole Welsch, L Andrew Lyon
We present a systematic study of self-cross-linked microgels formed by precipitation polymerization of oligo ethylene glycol methacrylates. The cross-linking density of these microgels and, thus, the network flexibility can be easily tuned through the modulation of the reaction temperature during polymerization. Microgels prepared in absence of any difunctional monomer, i.e. cross-linker, show enhanced deformability and particle spreading on solid surfaces as compared to microgels cross-linked with varying amounts of poly(ethylene glycol diacrylate) (PEG-DA) in addition to self-crosslinking...
2017: PloS One
https://www.readbyqxmd.com/read/28719598/the-predictive-value-of-abcb1-abcg2-cyp3a4-5-and-cyp2d6-polymorphisms-for-risperidone-and-aripiprazole-plasma-concentrations-and-the-occurrence-of-adverse-drug-reactions
#16
C Rafaniello, M Sessa, F F Bernardi, M Pozzi, S Cheli, D Cattaneo, S Baldelli, M Molteni, R Bernardini, F Rossi, E Clementi, C Bravaccio, S Radice, A Capuano
We investigated in ninety Caucasian pediatric patients the impact of the main polymorphisms occurring in CYP3A, CYP2D6, ABCB1 and ABCG2 genes on second-generation antipsychotics plasma concentrations, and their association with the occurrence of adverse drug reactions. Patients with the CA/AA ABCG2 genotype had a statistically significant lower risperidone plasma concentration/dose ratio (Ct/ds) (P-value: 0.007) and an higher estimated marginal probability of developing metabolism and nutrition disorders as compared to the ABCG2 c...
July 18, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28719591/non-equilibrium-dissipative-supramolecular-materials-with-a-tunable-lifetime
#17
Marta Tena-Solsona, Benedikt Rieß, Raphael K Grötsch, Franziska C Löhrer, Caren Wanzke, Benjamin Käsdorf, Andreas R Bausch, Peter Müller-Buschbaum, Oliver Lieleg, Job Boekhoven
Many biological materials exist in non-equilibrium states driven by the irreversible consumption of high-energy molecules like ATP or GTP. These energy-dissipating structures are governed by kinetics and are thus endowed with unique properties including spatiotemporal control over their presence. Here we show man-made equivalents of materials driven by the consumption of high-energy molecules and explore their unique properties. A chemical reaction network converts dicarboxylates into metastable anhydrides driven by the irreversible consumption of carbodiimide fuels...
July 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28719578/de-novo-active-sites-for-resurrected-precambrian-enzymes
#18
Valeria A Risso, Sergio Martinez-Rodriguez, Adela M Candel, Dennis M Krüger, David Pantoja-Uceda, Mariano Ortega-Muñoz, Francisco Santoyo-Gonzalez, Eric A Gaucher, Shina C L Kamerlin, Marta Bruix, Jose A Gavira, Jose M Sanchez-Ruiz
Protein engineering studies often suggest the emergence of completely new enzyme functionalities to be highly improbable. However, enzymes likely catalysed many different reactions already in the last universal common ancestor. Mechanisms for the emergence of completely new active sites must therefore either plausibly exist or at least have existed at the primordial protein stage. Here, we use resurrected Precambrian proteins as scaffolds for protein engineering and demonstrate that a new active site can be generated through a single hydrophobic-to-ionizable amino acid replacement that generates a partially buried group with perturbed physico-chemical properties...
July 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28719571/mir-27b-3p-suppressed-osteogenic-differentiation-of-maxillary-sinus-membrane-stem-cells-by-targeting-sp7
#19
Wei Peng, Shuangxi Zhu, Xiang Li, Junquan Weng, Songling Chen
OBJECTIVE: To explore the critical role and function of miRNAs in the regulation of development and physiology of maxillary sinus membrane stem cell (MSMSC) osteogenesis. METHODS: Microarray analysis was performed to screen the miRNAs expression profiles during the process of MSMSC osteogenic differentiation. Quantitative real-time polymerase chain reaction was applied to verify the miRNAs expression profiles. Gain- and loss-of-function experiments were used to demonstrate that miR-27b-3p inhibited MSMSC osteoblastic differentiation...
July 14, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28719544/postoperative-pyoderma-gangrenosum-in-children-the-case-report-of-a-13-year-old-boy-with-pyoderma-gangrenosum-after-hip-reconstruction-surgery-and-a-review-of-the-literature
#20
Nina Berger, Michael Ebenhoch, Maya Salzmann
BACKGROUND: Postoperative pyoderma gangrenosum (PG) is a neutrophilic dermatosis and pathergic reaction at surgical sites. Reports of children with postoperative PG are rare in the literature. METHODS: We report the case of a 13-year-old boy without any known preexisting illnesses, who developed severe systemic response and wound deterioration after elective hip reconstruction surgery. The working diagnosis of necrotizing fasciitis was later determined to be postoperative PG...
July 17, 2017: Journal of Pediatric Orthopedics
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