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https://www.readbyqxmd.com/read/28815900/mechanically-interlocked-molecules-mims-molecular-shuttles-switches-and-machines-nobel-lecture
#1
REVIEW
J Fraser Stoddart
Chemistry welcomes a new bond: The mechanical bond has endowed molecules with component parts whose movements can be controlled and monitored. In his Nobel Lecture, J. F. Stoddart describes how being able to template the formation of mechanically interlocked molecules has led to the design and synthesis of shuttles, switches, and machines at the nanoscale.
August 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28810347/-history-of-world-neurosurgery
#2
X Wang
In 5000 BC, South American tribes digged the bones in the living head to seek ways to communicate with the gods, which was primitive trephination and may be the first neurosurgical behavior. In 2600 BC, Imhotep in ancient Egypt took the brain out of the head from the nose, for a better preserve of the mummy, which was a prototype of modern transsphenoidal surgery. And the development of anatomy in ancient Greek laid a solid foundation for neurosurgery. From 500 to 1500 AD, the rise of religion and the occurrence of war, prompted a large number of craniocerebral trauma, which contributed greatly to the early development of neurosurgery as a distinct specialty...
May 28, 2017: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28804857/nobel-prize-nominees-hundred-years-ago-abraham-jacobi-1830-1919-and-otto-heubner-1843-1926
#3
Nils Hansson, Anne Oommen-Halbach, Arndt Borkhardt, Heiner Fangerau
Pediatrics directly and indirectly played an important role in the history of the Nobel Prize in physiology or medicine. However, the history of the Nobel Prize and pediatrics goes beyond the actual laureates. Based on original files in the archive of the Nobel committee of physiology or medicine at the Karolinska Institute in Sweden, this overview aims to shed new light on why the international pioneers of pediatrics Abraham Jacobi (1830-1919) and Otto Heubner (1843-1926) were nominated but never received the prize in 1918...
August 13, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28799689/fusion-and-scission-of-membranes-ubiquitous-topological-transformations-in-cells
#4
Roland L Knorr, Noboru Mizushima, Rumiana Dimova
2016 Nobel Prizes were awarded to Yoshinori Ohsumi for autophagy and to David Thouless, Duncan Haldane and Michael Kosterlitz for topological transitions. Both of these phenomena are intrinsically related when it comes to membranes. Here, we give a brief account on topological transformations of lipid membranes, commonly known as membrane fusion and membrane scission, and introduce the underlying topological invariant, the genus. The genus of a shape is a useful concept to distinguish unambiguously the processes of membrane fusion/scission and offers a simple method to describe complex, cellular membrane structures, such as fenestrated cristae...
August 11, 2017: Traffic
https://www.readbyqxmd.com/read/28780738/john-p-craig-md-mph-physician-scientist-educator-and-mentor-1923-2016
#5
M A Haseeb, Pascal James Imperato
John P. Craig (1923-2016) was an eminent physician-scientist, gifted educator, and greatly valued mentor. Born in West Liberty, Ohio on 29 November 1923, he attended Oberlin College, and received his medical degree from Case Western Reserve University, School of Medicine. This was followed by an internship at Yale University Medical Center, and then service in the U.S. Army during the Korean War. He was a battalion surgeon, preventive medicine officer, and epidemiologist. While in Korea, he conducted important investigations of hemorrhagic fever among American troops...
August 5, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28757938/postextraction-computer-guided-implant-surgery-in-partially-edentate-patients-with-metal-restorations-a-case-report
#6
A Pinto, C Raffone
OBJECTIVES: The aim of the present study was to describe a postextraction, computer-guided protocol for implant-prosthetic rehabilitations in partially edentate patients with metal restorations. METHODS: A 60-year-old man with a loose FDP (fixed dental prosthesis) in the first quadrant was selected for a postextraction computer guided implantology according with the 2-piece radiographic template protocol. A two components radiographic template was produced, with the teeth setup portion based on the wax-up...
January 2017: Oral & Implantology
https://www.readbyqxmd.com/read/28756294/vitamin-d-cod-liver-oil-sunshine-and-phototherapy-safe-effective-and-forgotten-tools-for-treating-and-curing-tuberculosis-infections-a-comprehensive-review
#7
REVIEW
Patrick J McCullough, Douglas S Lehrer
Tuberculosis remains an epidemic throughout the world, with over 2 billion people, or more than one third of the world's population, infected with TB. In 2015, there were an estimated 10.4 million new cases of tuberculosis, and 1.8 million deaths, making TB one of the top ten causes of death worldwide. Approximately 95% of new TB cases occur in developing countries, where the costs of treatment force many patients and their families into poverty. The United Nations and the World Health Organization are working to end this global epidemic...
July 26, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28756009/flaws-in-the-lnt-single-hit-model-for-cancer-risk-an-historical-assessment
#8
REVIEW
Edward J Calabrese
The LNT single-hit model was derived from the Nobel Prize-winning research of Herman J. Muller who showed that x-rays could induce gene mutations in Drosophila and that the dose response for these so-called mutational events was linear. Lewis J. Stadler, another well-known and respected geneticist at the time, strongly disagreed with and challenged Muller's claims. Detailed evaluations by Stadler over a prolonged series of investigations revealed that Muller's experiments had induced gross heritable chromosomal damage instead of specific gene mutations as had been claimed by Muller at his Nobel Lecture...
July 26, 2017: Environmental Research
https://www.readbyqxmd.com/read/28748095/the-origin-of-mathematics-and-number-sense-in-the-cerebellum-with-implications-for-finger-counting-and-dyscalculia
#9
Larry Vandervert
BACKGROUND: Mathematicians and scientists have struggled to adequately describe the ultimate foundations of mathematics. Nobel laureates Albert Einstein and Eugene Wigner were perplexed by this issue, with Wigner concluding that the workability of mathematics in the real world is a mystery we cannot explain. In response to this classic enigma, the major purpose of this article is to provide a theoretical model of the ultimate origin of mathematics and "number sense" (as defined by S. Dehaene) that is proposed to involve the learning of inverse dynamics models through the collaboration of the cerebellum and the cerebral cortex (but prominently cerebellum-driven)...
2017: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/28742484/the-2016-nobel-prize-for-chemistry-awarded-for-the-design-and-synthesis-of-molecular-machines
#10
Christopher J Rhodes
No abstract text is available yet for this article.
December 1, 2016: Science Progress
https://www.readbyqxmd.com/read/28741439/rudolf-ulrich-kr%C3%A3-nlein-1847-1910-an-innovative-general-thoracic-neuro-and-ocular-surgeon
#11
Konstantinos Laios
The Swiss Professor Rudolf Ulrich Krönlein (1847-1910) was a pioneer in many fields of surgery, because he succeeded in introducing many innovations in different fields of surgery, for example, general surgery, thoracic surgery, neurosurgery, and ocular surgery. He was a reputable Professor of Surgery at Zurich University and was nominated for Nobel Prize in 1902.
July 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28741072/-the-69th-congress-urologists-nominated-for-the-nobel-prize-not-everyone-got-a-prize-four-biographical-sketches
#12
F H Moll, T Halling, M Krischel, N Hansson, H Fangerau
Our research group has reconstructed why the board certified urologists Werner Forssmann (1904-1979) and Charles Huggins (1901-1997) received the Nobel Prize in physiology or medicine (1956, and 1966, respectively). But the history of "Urology and the Nobel Prize" is in fact more multifaceted than the success stories of these two laureates suggest. James Israel (1848-1926), Berlin, Félix Guyon (1831-1920), Paris, Peter J. Freyer (1852-1921), London and Edwin Beer (1876-1938), New York were nominated for the award during the first three decades of the 20th century...
July 24, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28725094/evolution-of-three-nobel-prize-themes-and-a-nobel-snub-theme-in-chemistry-a-bibliometric-study-with-focus-on-international-collaboration
#13
Sichao Tong, Per Ahlgren
In this study, three chemistry research themes closely associated with the Nobel Prize are bibliometrically analyzed-Ribozyme, Ozone and Fullerene-as well as a research theme in chemistry not associated with the Nobel Prize (a Nobel snub theme): Brunauer-Emmett-Teller equation. We analyze, based on an algorithmically constructed publication-level classification system, the evolution of the four themes with respect to publication volume and international collaboration, using two datasets, one of them a subset of highly cited publications, for each considered time period...
2017: Scientometrics
https://www.readbyqxmd.com/read/28715979/a-serendipitous-scientist
#14
Robert J Lefkowitz
Growing up in a middle-class Jewish home in the Bronx, I had only one professional goal: to become a physician. However, as with most of my Vietnam-era MD colleagues, I found my residency training interrupted by the Doctor Draft in 1968. Some of us who were academically inclined fulfilled this obligation by serving in the US Public Health Service as commissioned officers stationed at the National Institutes of Health. This experience would eventually change the entire trajectory of my career. Here I describe how, over a period of years, I transitioned from the life of a physician to that of a physician scientist; my 50 years of work on cellular receptors; and some miscellaneous thoughts on subjects as varied as Nobel prizes, scientific lineages, mentoring, publishing, and funding...
July 17, 2017: Annual Review of Pharmacology and Toxicology
https://www.readbyqxmd.com/read/28699494/the-small-molecules-targeting-ubiquitin-proteasome-system-for-cancer-therapy
#15
Nannan Ao, Qianping Chen, Geng Liu
The ubiquitin-proteasome system (UPS) is responsible for the degradation of majority of the intracellular proteins. The fundamental importance of UPS was highlighted when Rose, Hershko, and Ciechanover were awarded the 2004 Nobel Prize in Chemistry. The alterations in this process have been shown to contribute to the cancer progression. Therefore, pharmacological targeting of the UPS can potentially provide chemotherapeutics for the treatment of tumours. The application of bortezomib proved that interfering with UPS activity could be very effective against haematological malignancies...
July 10, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28686374/-spatial-navigation-brief-overview-of-the-medicine-and-physiology-nobel-prize-2014
#16
Franciscus Boselie, Jean-Philippe Guyot
Various cells of the thalamus, hippocampus, and the medial entorhinal cortex plays a crucial role in spatial navigation ability. The highlighting of these cells and the understanding of their functioning by John O'Keefe, May-Britt and Edvard Moser have earned them the Nobel Prize for Medicine and Physiology in 2014. The vision, olfaction, and the vestibular system contribute to this complex system. These observations may well explain why patients with vestibular disorder complain of spatial disorientation, often a source of deep anxiety...
October 5, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28678417/stochastic-optical-reconstruction-microscopy-storm
#17
Jianquan Xu, Hongqiang Ma, Yang Liu
Super-resolution (SR) fluorescence microscopy, a class of optical microscopy techniques at a spatial resolution below the diffraction limit, has revolutionized the way we study biology, as recognized by the Nobel Prize in Chemistry in 2014. Stochastic optical reconstruction microscopy (STORM), a widely used SR technique, is based on the principle of single molecule localization. STORM routinely achieves a spatial resolution of 20 to 30 nm, a ten-fold improvement compared to conventional optical microscopy...
July 5, 2017: Current Protocols in Cytometry
https://www.readbyqxmd.com/read/28660642/towards-inclusive-occupational-therapy-introducing-the-core-approach-for-inclusive-and-occupation-focused-practice
#18
Robert B Pereira
BACKGROUND/AIM: Occupation is a human right and a social determinant of health. It is also taken for granted. Having access to, and participating in, occupation, is intricately linked to positive health and wellbeing. Despite theory and evidence to support the link between occupation, health and wellbeing, occupational therapists can struggle with applying an occupation focus in practice and knowing how to use occupational frameworks to enable occupation. The purpose of this paper is to introduce the Capabilities, Opportunities, Resources and Environments (CORE) approach for inclusive and occupation-focused practice...
June 29, 2017: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/28657492/efficacy-of-losartan-as-add-on-therapy-to-prevent-aortic-growth-and-ventricular-dysfunction-in-patients-with-marfan-syndrome-a-randomized-double-blind-clinical-trial
#19
Laura Muiño-Mosquera, Sylvia De Nobele, Daniel Devos, Laurence Campens, Anne De Paepe, Julie De Backer
BACKGROUND: Marfan syndrome (MFS) is a multisystemic hereditary connective tissue disease. Aortic root aneurysms and dissections are the most common and life-threatening cardiovascular disorders affecting these patients. Other cardiac manifestations include mitral valve prolapse, ventricular dysfunction and arrhythmias. Medical treatment of cardiovascular features is ultimately aimed at slowing down aortic root growth rate and preventing dissection. Losartan has been proposed as a new therapeutic tool for this purpose...
June 28, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28656847/the-telomere-effect-a-revolutionary-approach-to-living-younger-healthier-longer-blackburn-elizabeth-and-epel-elissa-the-telomere-effect-a-revolutionary-approach-to-living-younger-healthier-longer-417pp-%C3%A2-14-99-orion-books-9780297609230-0297609238-formula-see
#20
(no author information available yet)
Elizabeth Blackburn received a Nobel prize for discovering the molecular nature of telomeres (the ends of our chromosomes that serve as protective caps) and telomerase (the enzyme that maintains telomeres).
June 28, 2017: Nursing Standard
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