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Talha Burki
No abstract text is available yet for this article.
October 14, 2017: Lancet
Ioannis N Mammas, Demetrios A Spandidos
Dr Neda Voutsa-Perdiki, former Director of Exfoliative Cytology at the University of Florida (Florida, USA), talks about her academic teacher Dr George N. Papanicοlaou, referred to as the 'Father of Exfoliative Cytology', and his wife Mache, known as Mary Papanicolaou. According to Dr Voutsa-Perdiki, Dr Papanicolaou was an exceptional teacher and a unique humanitarian in modern medical history. The secret of his scientific success was hard work, dedication, love of research, faith and the courage he gained from his wife and colleagues...
October 2017: Experimental and Therapeutic Medicine
Ioannis N Mammas, Demetrios A Spandidos
Born in Gelsenkirchen-Buer in Germany on March 11th, 1936, Professor Harald zur Hausen, Emeritus Professor of Virology at the University of Freiburg and 2008 Nobel Prize Laureate in Physiology or Medicine for his discovery of human papillomavirus (HPV), which causes cervical cancer, believes that good knowledge of virological methods and diagnostic possibilities are an asset for all young paediatricians. Professor zur Hausen considers that the creation of an educational platform on Paediatric Virology is definitely very beneficial for young paediatricians, as this will greatly enhance their knowledge in the field of Virology...
October 2017: Experimental and Therapeutic Medicine
Mia Tuft, Karl O Nakken
In Scandinavia, at least 11.500 people were lobotomized in the period 1939-1983. Beside grave personality changes, the surgery caused epilepsy in 10-35% of the patients. Moreover, many died due to perioperative bleedings, convulsive status epilepticus or SUDEP. Most of the stories of these people are anonymous and their post-lobotomy lives are scarcely documented. If it was not for the fact that Ellinor Hamsun (1916-1987) was the daughter of the famous Nobel Prize winning Norwegian author Knut Hamsun, her lobotomy story and the subsequent iatrogenic epilepsy would probably have remained unknown...
2017: Epilepsy & Behavior Case Reports
Gen Li, Andrey A Shabalin, Ivan Rusyn, Fred A Wright, Andrew B Nobel
Expression quantitative trait locus (eQTL) analyses identify genetic markers associated with the expression of a gene. Most up-to-date eQTL studies consider the connection between genetic variation and expression in a single tissue. Multi-tissue analyses have the potential to improve findings in a single tissue, and elucidate the genotypic basis of differences between tissues. In this article, we develop a hierarchical Bayesian model (MT-eQTL) for multi-tissue eQTL analysis. MT-eQTL explicitly captures patterns of variation in the presence or absence of eQTL, as well as the heterogeneity of effect sizes across tissues...
September 25, 2017: Biostatistics
Daniel Cressey, Ewen Callaway
No abstract text is available yet for this article.
October 4, 2017: Nature
Harold Elliss
No abstract text is available yet for this article.
October 2, 2017: British Journal of Hospital Medicine
Andreas Friebe, Peter Sandner, Achim Schmidtko
Although the Nobel Prize for the discovery of nitric oxide (NO) dates back almost 20 years now, the knowledge about cGMP signaling is still constantly increasing. It looks even so that our understanding of the role of the soluble guanylyl cyclase (sGC) and particulate guanylyl cyclase (pGC) in health and disease is in many aspects at the beginning and far from being understood. This holds even true for the therapeutic impact of innovative drugs acting on both the NO/sGC and the pGC pathways. Since cGMP, as second messenger, is involved in the pathogenesis of numerous diseases within the cardiovascular, pulmonary, renal, and endocrine systems and also plays a role in neuronal, sensory, and tumor processes, drug applications might be quite broad...
October 10, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
Lisa Nobel, William M Jesdale, Jennifer Tjia, Molly E Waring, David C Parish, Arlene S Ash, Catarina I Kiefe, Jeroan J Allison
OBJECTIVE: To explore the influence of contextual factors on health-related quality of life (HRQoL), which is sometimes used as an indicator of quality of care, we examined the association of neighborhood socioeconomic status (NSES) and trajectories of HRQoL after hospitalization for acute coronary syndromes (ACS). METHODS: We studied 1481 patients hospitalized with acute coronary syndromes in Massachusetts and Georgia querying HRQoL via the mental and physical components of the 36-item short-form health survey (SF-36) (MCS and PCS) and the physical limitations and angina-related HRQoL subscales of the Seattle Angina Questionnaire (SAQ) during hospitalization and at 1-, 3-, and 6-month postdischarge...
October 9, 2017: Medical Care
Patrick P Weil, Yan Jaszczyszyn, Anne Baroin-Tourancheau, Jan Postberg, Laurence Amar
Small and long noncoding RNAs (ncRNAs) are key regulators of gene expression. Variations in ncRNA expression patterns can consequently affect the control of many cellular processes. Not just since 2006, when Andrew Z Fire and Craig C Mello were jointly awarded The Nobel Prize in Physiology or Medicine for their discovery of RNA interference, great efforts were undertaken to unleash the biomedical applicability of small noncoding RNAs, in particular microRNAs. With the technological evolution of massive parallel sequencing technologies over the last years, which now are available for an increasing number of scientists, there is a demand for comprehensible and efficient workflows reliable even for unique and valuable clinical specimens...
2017: Methods in Molecular Biology
Adrian Cho
No abstract text is available yet for this article.
October 6, 2017: Science
Ewen Callaway, Heidi Ledford
No abstract text is available yet for this article.
October 2, 2017: Nature
(no author information available yet)
No abstract text is available yet for this article.
October 4, 2017: Nature
Davide Castelvecchi
No abstract text is available yet for this article.
October 3, 2017: Nature
Marco Artico, Marialuisa Spoletini, Lorenzo Fumagalli, Francesca Biagioni, Larisa Ryskalin, Francesco Fornai, Maurizio Salvati, Alessandro Frati, Francesco Saverio Pastore, Samanta Taurone
In June 2017 we celebrate the 90th anniversary of the pioneer discovery of cerebral angiography, the seminal imaging technique used for visualizing cerebral blood vessels and vascular alterations as well as other intracranial disorders. Egas Moniz (1874-1955) was the first to describe the use of this revolutionary technique which, until 1975 (when computed tomography, CT, scan was introduced in the clinical practice), was the sole diagnostic tool to provide an imaging of cerebral vessels and therefore alterations due to intracranial pathology...
2017: Frontiers in Neuroanatomy
Iñaki Cercadillo-Ibarguren, Alba Sánchez-Torres, Rui Figueiredo, Frank Schwarz, Cosme Gay-Escoda, Eduard Valmaseda-Castellón
OBJECTIVE: Evaluate the peri-implant status on the long-term (1-9years) of patients treated with immediately-loaded full-arch prostheses in a private practice. METHODS: A retrospective cohort study was carried out in patients consecutively treated with immediately loaded full-arch restorations supported with a minimum of 4 implants (Replace(®) Tapered, Nobel Biocare AB) and Multi-Unit conical abutments (MUA(®), Nobel Biocare AB) with a follow-up of over 12months after placement of the final prosthesis...
September 28, 2017: Journal of Dentistry
Jeanine A Harrigan, Xavier Jacq, Niall M Martin, Stephen P Jackson
More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin-proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors, first-generation deubiquitylating enzyme (DUB) inhibitors are now approaching clinical trials. However, although our knowledge of the physiological and pathophysiological roles of DUBs has evolved tremendously, the clinical development of selective DUB inhibitors has been challenging. In this Review, we discuss these issues and highlight recent advances in our understanding of DUB enzymology and biology as well as technological improvements that have contributed to the current interest in DUBs as therapeutic targets in diseases ranging from oncology to neurodegeneration...
September 29, 2017: Nature Reviews. Drug Discovery
Kamran Mousavi Hosseini, Mehran Ghasemzadeh
CONTEXT: The major motivation for the preparation of the plasma derived biological medicine was the treatment of casualties from the Second World War. Due to the high expenses for preparation of plasma derived products, achievement of self-sufficiency in human plasma biotechnological industry is an important goal for developing countries. EVIDENCE ACQUISITION: The complexity of the blood plasma was first revealed by the Nobel Prize laureate, Arne Tiselius and Theodor Svedberg, which resulted in the identification of thousands of plasma proteins...
December 2016: Iranian journal of biotechnology
Teodor K Todorov, Saurabh Singh, Douglas M Bishop, Oki Gunawan, Yun Seog Lee, Talia S Gershon, Kevin W Brew, Priscilla D Antunez, Richard Haight
Selenium was used in the first solid state solar cell in 1883 and gave early insights into the photoelectric effect that inspired Einstein's Nobel Prize work; however, the latest efficiency milestone of 5.0% was more than 30 years ago. The recent surge of interest towards high-band gap absorbers for tandem applications led us to reconsider this attractive 1.95 eV material. Here, we show completely redesigned selenium devices with improved back and front interfaces optimized through combinatorial studies and demonstrate record open-circuit voltage (V OC) of 970 mV and efficiency of 6...
September 25, 2017: Nature Communications
Mauro Merli, Eugenio Bianchini, Giorgia Mariotti, Marco Moscatelli, Matteo Piemontese, Giorgio Rappelli, Michele Nieri
PURPOSE: The objectives of this two-period, crossover, mono-centred, double-blind, randomised controlled trial (RCT) were to compare two different materials used for full arch implant-supported prosthetic restorations with regard to patient preference and impact on a patient's quality of life. MATERIALS AND METHODS: Edentulous patients requesting one full arch restoration in the mandible or maxilla supported by dental implants were included in this study. Patients were randomised to receive either a full arch zirconia framework hand-veneered with ceramic, or a full arch zirconia framework hand-veneered with composite material...
2017: European Journal of Oral Implantology
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