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https://www.readbyqxmd.com/read/28530842/the-past-present-and-future-of-gene-therapy-from-nobel-laureate-david-baltimore
#1
James M Wilson
No abstract text is available yet for this article.
May 22, 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/28528032/a-surprising-alliance-two-giants-of-the-20th-century
#2
Robert M Sade
Alexis Carrel and Charles Lindbergh were among the most famous international figures in the 20th century: Carrel, the surgeon-scientist who won a Nobel prize as a young surgeon, and Lindbergh, the aviator-engineer who pioneered aviation and promoted commercial flight throughout his life. Surprisingly, these two amazing individuals came together to collaborate on the early development of extracorporeal circulation. Their work was interrupted by the onset of World War II, which destroyed one of them and nearly destroyed the other...
June 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28520684/pediatric-trauma-undertriage-in-ohio
#3
Juan P Gurria, Lynn Haas, Misty Troutt, Suzanne Moody, Md Monir Hossain, Mohammad Alfrad Nobel Bhuiyan, Richard A Falcone
BACKGROUND: Appropriate and timely triage is an essential component of a trauma system. In the state of Ohio, there are 6 verified pediatric trauma centers (PTCs) across 8 state regions. The purpose of this study was to better understand the pediatric undertriage rates in the state. METHODS: We used the Ohio Trauma Registry from 2007 to 2012, consisting of 14,045 records of children younger than 16 years admitted to a hospital for more than 48 hours or who sustained a traumatic death...
June 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28512195/an-interview-with-eric-wieschaus
#4
Aidan Maartens
Eric Wieschaus is a HHMI Investigator, and the Squibb Professor in Molecular Biology at Princeton University and the Lewis-Sigler Institute for Integrative Genomics. In 1995, he was awarded the Nobel Prize jointly with Edward Lewis and Christiane Nüsslein-Volhard for discoveries about the genetic control of Drosophila embryogenesis. We caught up with Eric at the joint meeting of the German and Japanese Societies of Developmental Biologists held in Kiel in March 2017, and discussed his career, his thoughts on the field and the impact the Nobel award had on his life...
May 15, 2017: Development
https://www.readbyqxmd.com/read/28511200/enteric-infection-in-relapse-of-inflammatory-bowel-disease-the-utility-of-stool-microbial-pcr-testing
#5
Jordan E Axelrad, Andrew Joelson, Yael R Nobel, Garrett Lawlor, Peter H R Green, Simon Lichtiger, Benjamin Lebwohl
BACKGROUND: The similar presentations in relapse of inflammatory bowel disease (IBD) and enteric infection pose substantial barriers to diagnosis and treatment. The objective of this study was to investigate the incidence, etiology, predictors, and treatment of enteric infection in patients with IBD. METHODS: We reviewed the records of 214 patients with IBD who underwent 295 gastrointestinal pathogen panel and Clostridium difficile infection (CDI) polymerase chain reaction (PCR) stool tests during an exacerbation of symptoms...
June 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28506430/george-e-palade-memorial-lecture-my-life-in-pancreatic-research-unexpected-results-may-open-the-door
#6
REVIEW
Makoto Otsuki
The Palade Prize is the most distinguished award of the IAP for achievement in pancreatic research. It is named after George E. Palade, who in 1974 was awarded the Nobel Prize for his work on protein trafficking in pancreatic acinar cells. It is a great honor to be awarded the 2016 Palade Prize. While I was in graduate school, I was conducting research on hypothalamo-pituitary-thyroid axis; after finishing graduate school, I began research on amylase isoenzymes. This was the first step of my pancreatic research...
May 6, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28504815/the-arago-laboratory-of-banyuls-and-some-of-its-academicians
#7
Marie-Odile Soyer-Gobillard
Since its founding in 1881 by Henri de Lacaze-Duthiers (1821-1901), the Arago Laboratory of Banyuls has been one of the three marine stations of the University Pierre and Marie Curie-Paris 6. It is located in Banyuls (Banyuls-sur-Mer) in Northern Catalonia. The center hosts researchers and students from all over the world. Some became famous, including four Nobel Prize winners: André Lwoff (1965), Pierre-Gilles de Gennes (1991), Albert Fert (2007) and Jules Hoffmann (2011). This article focuses on five scientists closely related to the center...
December 2016: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/28504774/yoshinori-ohsumi-s-nobel-prize-for-mechanisms-of-autophagy-from-basic-yeast-biology-to-therapeutic-potential
#8
D C Rubinsztein, R A Frake
On 3 October 2016, Japanese cell biologist Yoshinori Ohsumi was awarded the Nobel Prize in Physiology or Medicine 'for his discoveries of mechanisms for autophagy'; autophagy being an intracellular degradation pathway that helps maintain cytoplasmic homeostasis. This commentary discusses Ohsumi's Nobel prize-winning work in context, before explaining the clinical relevance of autophagy.
December 2016: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/28471291/thomas-mann-s-depiction-of-neurosyphilis-and-other-diseases
#9
François Boller, Nicoletta Caputi
Thomas Mann (1875-1955), a Nobel Prize recipient rightly considered one of the great novelists of the twentieth century, was one of the most medically perceptive writers of recent times. His novels take place against the background of the different plagues (tuberculosis, cholera) that characterized the eighteenth and nineteenth centuries. One of Mann's later novels, Doctor Faustus, is set against a background of syphilis. In the 500-page book, which is subtitled The Life of the German Composer Adrian Leverkühn as told by a Friend, we see the theologian turned composer make a pact with the devil...
May 4, 2017: Journal of the History of the Neurosciences
https://www.readbyqxmd.com/read/28465332/an-interview-with-john-gurdon
#10
Aidan Maartens
John Gurdon is a Distinguished Group Leader in the Wellcome Trust/Cancer Research UK Gurdon Institute and Professor Emeritus in the Department of Zoology at the University of Cambridge. In 2012, he was awarded the Nobel Prize in Physiology or Medicine jointly with Shinya Yamanaka for work on the reprogramming of mature cells to pluripotency, and his lab continues to investigate the molecular mechanisms of nuclear reprogramming by oocytes and eggs. We met John in his Cambridge office to discuss his career and hear his thoughts on the past, present and future of reprogramming...
May 1, 2017: Development
https://www.readbyqxmd.com/read/28453001/mechanical-complications-associated-with-angled-screw-channel-restorations
#11
Anna C Greer, Philippa J Hoyle, Joseph W Vere, Phillip F Wragg
The aim of this study was to identify mechanical complications associated with Nobel Biocare's angled screw channel (ASC) restorations following provision of the definitive crown. All ASC restorations provided between 1 January 2014 and 19 January 2016 were identified. Patients' clinical records were reviewed for demographic details, implant characteristics, occlusal considerations, and complications. A total of 84 implants placed in 60 patients were included. Three patients (4%) returned with mechanical complications, but the majority (n = 81; 96%) had no recorded complications...
May 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/28442477/nobel-laureate-a-v-hill-and-the-refugee-scholars-1933-1945
#12
Jack A Rall
A. V. Hill shared the 1922 Nobel Prize in Physiology or Medicine for his investigation of the energetics of muscular contraction. His scientific work has been well chronicled over many years (Rall JA. Mechanism of Muscular Contraction, 2014). There is the natural tendency to focus solely on an investigator's scientific achievements. But in the case of Hill, it has been said (Katz B. Biogr Mem Fellows R Soc 24: 71-149, 1978) that "it was his devotion to such wider issues, outside the boundaries of his own research, through which he exerted his most important influence on other people's lives and on the course of events...
June 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/28438168/upon-entering-an-age-of-global-ivermectin-based-integrated-mass-drug-administration-for-neglected-tropical-diseases-and-malaria
#13
Frank O Richards
Ivermectin mass drug administration (MDA) in humans to reduce malaria vectors is yet another use for this remarkable medicine whose discoverers shared the 2015 Nobel Prize in Medicine with the discoverer of artemisinin. The malaria community should join those who have long used ivermectin MDA in an integrated battle to break transmission of three vector-borne parasitic diseases.
April 24, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28436150/george%C3%A2-a-olah-1927-2017
#14
G K Surya Prakash
George Andrew Olah, Founding Director, Loker Hydrocarbon Research Institute at the University of Southern California, passed away on March 8, 2017. Olah was awarded the Nobel Prize in Chemistry 1994 for his work on the stabilization of carbocations in superacids. In recent years he was highly active in establishing a methanol economy, in which carbon dioxide is converted to methanol for use as a fuel or feedstock.
April 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28425586/introduction-to-nobel-conference-the-cell-cycle-and-cell-death-in-disease
#15
K G Wiman, B Zhivotovsky
No abstract text is available yet for this article.
May 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28411887/from-christian-de-duve-to-yoshinori-ohsumi-more%C3%A2-to-autophagy-than-just-dining-at-home
#16
REVIEW
Margaret M Harnett, Miguel A Pineda, Perle Latré de Laté, Russell J Eason, Sébastien Besteiro, William Harnett, Gordon Langsley
Christian de Duve first coined the expression "autophagy" during his seminal work on the discovery of lysosomes, which led to him being awarded the Nobel Prize in Physiology or Medicine in 1974. The term was adopted to distinguish degradation of intracellular components from the uptake and degradation of extracellular substances that he called "heterophagy". Studies until the 1990s were largely observational/morphological-based until in 1993 Yoshinori Oshumi described a genetic screen in yeast undergoing nitrogen deprivation that led to the isolation of autophagy-defective mutants now better known as ATG (AuTophaGy-related) genes...
February 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28411883/horning-cell-self-digestion-autophagy-wins-the%C3%A2-2016-nobel-prize-in-physiology-or-medicine
#17
EDITORIAL
Po-Yuan Ke
Autophagy is an evolutionarily conserved process by which eukaryotic cells eliminate intracellular components via the lysosomal degradation process. This cell self-digestion process was first discovered and morphologically characterized in the late 1950s and early 1960s. The genetic screen studies in baker's yeast in the 1990s further identified the essential genes functioning in the autophagic process. In the past two decades, the detailed molecular process involved in the completion of autophagy was delineated...
February 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28411878/food-for-thought-autophagy-researcher-wins-2016-nobel-prize-in-physiology-or-medicine
#18
EDITORIAL
Emma Louise Walton
This special edition of the Biomedical Journal honors the awarding of the 2016 Nobel Prize in Physiology and Medicine to Yoshinori Ohsumi for his pioneering work on elucidating the mechanisms of autophagy. We also highlight a study reporting a new and simple animal model for a widespread surgical technique called interbody spinal fusion. Finally, this issue also includes two articles reporting protocols that could produce specific cell types for cell based therapies.
February 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28403247/early-complications-of-immediate-loading-in-edentulous-full-arch-restorations-a-retrospective-analysis-of-88-cases
#19
Iñaki Cercadillo-Ibarguren, Alba Sánchez-Torres, Rui Figueiredo, Eduard Valmaseda-Castellón
PURPOSE: To describe the clinical outcomes and complications related to provisional prostheses after full-arch implant-supported rehabilitation by means of an immediate loading protocol. MATERIALS AND METHODS: This retrospective cohort study included patients who were consecutively treated with full-arch implant-supported restorations with a minimum of four implants (Replace Select Tapered TiUnite, Nobel Biocare AB) per arch and conical abutments (multi-unit, Nobel Biocare AB) by means of an immediate loading protocol...
April 12, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28400114/autophagy-nobel-prize-2016-and-allergy-and-asthma-research
#20
EDITORIAL
Harald Renz
No abstract text is available yet for this article.
April 8, 2017: Journal of Allergy and Clinical Immunology
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