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https://www.readbyqxmd.com/read/28208737/special-issue-on-ruthenium-complexes
#1
EDITORIAL
Ileana Dragutan, Valerian Dragutan, Albert Demonceau
The organic chemistry of ruthenium has been one of the most vigorously growing research areas over the past decades. Considerable effort has been extended towards the design and application of a broad series of ruthenium complexes, which culminated with the development by Ryoji Noyori (2001 Nobel Prize for Chemistry) of chiral ruthenium catalysts for stereoselective hydrogenation reactions [1], and the discovery by Robert H. Grubbs (2005 Nobel Prize for Chemistry) of well-defined ruthenium- benzylidene catalysts for olefin metathesis [2] [...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28207255/supramolecular-complexation-of-carbon-nanostructures-by-crown-ethers
#2
Luis Moreira, Beatriz M Illescas, Nazario Martín
Since its discovery, crown ethers as well as the most recent carbon nanostructures, namely fullerenes, carbon nanotubes and graphene, have received a lot of attention from the chemical community. As a proof, these innovative chemical structures have gathered three Nobel Prizes in 1987, 1996 and 2010 corresponding to crown ethers, fullerenes and graphene, respectively. Merging these singular chemical structures has provided a wealth number of unprecedented supramolecular assemblies with new geometrical and electronic properties whose more representative examples have been presented in this synopsis organized according to the different nature of the carbon nanostructures...
February 16, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28202601/cell-scientist-to-watch-arun-shukla
#3
(no author information available yet)
Arun Shukla received his master's degree in Biotechnology from the Jawaharlal Nehru University in New Delhi, and joined the lab of Nobel laureate Hartmut Michel at the Max Planck Institute of Biophysics in Frankfurt, Germany, for his PhD. He then moved to the United States for his postdoctoral work with Robert Lefkowitz at Duke University (Durham, NC) in a very close collaboration with Brian Kobilka (Stanford University, CA). Arun became an Assistant Professor in the Department of Medicine at Duke University in 2011, before returning to India in April 2014 as an Assistant Professor at the Indian Institute of Technology (IIT) in Kanpur as a Wellcome Trust DBT India Alliance Intermediate Fellow...
February 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28196978/ivermectin-enigmatic-multifaceted-wonder-drug-continues-to-surprise-and-exceed-expectations
#4
REVIEW
Andy Crump
Over the past decade, the global scientific community have begun to recognize the unmatched value of an extraordinary drug, ivermectin, that originates from a single microbe unearthed from soil in Japan. Work on ivermectin has seen its discoverer, Satoshi Ōmura, of Tokyo's prestigious Kitasato Institute, receive the 2014 Gairdner Global Health Award and the 2015 Nobel Prize in Physiology or Medicine, which he shared with a collaborating partner in the discovery and development of the drug, William Campbell of Merck & Co...
February 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28186333/the-exponential-growth-of-autophagy-related-research-from-the-humble-yeast-to-the-nobel-prize
#5
Noboru Mizushima
Autophagy was discovered more than half a century ago. In the early days, autophagy was studied mostly through the use of biochemical methods and electron microscopy. In the 1990s, yeast genetics was introduced to this field and brought about an exponential expansion. The 2016 Nobel Prize in Physiology or Medicine was eventually awarded to the scientist who spearheaded the rapid development of the field: Yoshinori Ohsumi. Here, I describe in a Nutshell how the autophagy machinery was discovered and how the autophagy research field has grown following the breakthroughs from yeast studies...
February 10, 2017: FEBS Letters
https://www.readbyqxmd.com/read/28185409/a-retrospective-study-on-1592-consecutively-performed-operations-in-one-private-referral-clinic-part-i-early-inflammation-and-early-implant-failures
#6
Hadi Antoun, Michel Karouni, Jérémy Abitbol, Ons Zouiten, Torsten Jemt
BACKGROUND: Few large-scale follow-up studies are reported on routine implant treatment. PURPOSE: To report retrospective data on early inflammatory and early implant failures in a large number of routine patients at one private referral clinic. MATERIALS AND METHODS: A total of 1017 patients were consecutively provided with 3082 implants with an anodized surface (Nobel Biocare AB) at 1592 implant operations between 2000 and 2011. All patients reported with mucosa inflammation and bone loss and/or implant failures to the first annual examination were identified...
February 10, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28184943/analysis-of-chromosomal-radiosensitivity-of-healthy-brca2-mutation-carriers-and-non-carriers-in-brca-families-with-the-g2-micronucleus-assay
#7
Annelot Baert, Julie Depuydt, Tom Van Maerken, Bruce Poppe, Fransiska Malfait, Tim Van Damme, Sylvia De Nobele, Gianpaolo Perletti, Kim De Leeneer, Kathleen B M Claes, Anne Vral
Breast cancer risk drastically increases in individuals with a heterozygous germline BRCA1 or BRCA2 mutation, while it is estimated to equal the population risk for relatives without the familial mutation (non-carriers). The aim of the present study was to use a G2 phase-specific micronucleus assay to investigate whether lymphocytes of healthy BRCA2 mutation carriers are characterized by increased radiosensitivity compared to controls without a family history of breast/ovarian cancer and how this relates to healthy non-carrier relatives...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28181954/nobel-prize-and-surgical-pathology
#8
Badr AbdullGaffar
No abstract text is available yet for this article.
March 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28179607/half-a-century-tales-of-familial-hypercholesterolemia-fh-in-japan
#9
Hiroshi Mabuchi
Familial hypercholesterolemia (FH) is a disease characterized by a triad: elevated low-density lipoprotein (LDL) cholesterol, tendon xanthomas, and premature coronary heart disease. Thus, it can be considered as a model disease for hypercholesterolemia and atherosclerotic cardiovascular disease (ASCVD). For the diagnosis of hetero-FH, the detection of Achilles tendon xanthomas by palpation or on X-ray is an indispensable diagnostic skill in clinical lipidology. To prevent the under-diagnosis and under-treatment of FH, the diagnostic criteria should be more convenient and user-friendly...
February 8, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28168586/they-tamed-the-photon-early-days-of-radiation-dosimetry
#10
John R Patterson
This article is a tribute to the many physicists who tamed the photon in the service of mankind. Many received Nobel Prizes and other high awards. Several have units named after them. Some invented the equipment we use. Some sacrificed their lives before the hazards and benefits of radiation were fully understood. I discuss the progress over 120 years, both theoretical and technical, in the development of radiation protection regulations based on quantitative measurements and a consistent set of units, the gray and sievert...
February 6, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28168438/old-man-young-man-t-s-%C3%A2-eliot-s-gerontion-and-the-problem-of-identity
#11
Moritz E Wigand, Hauke F Wiegand, Markus Jäger, Thomas Becker
BACKGROUND: In his poem Gerontion (1920) Nobel laureate T.S. Eliot uses powerful language to give a fictional, highly condensed, first-person account of medical and psychological conditions that arise with old age: physical frailty, cognitive decline, sensory impairment, depressive symptoms with embitterment, social withdrawal and the psychological strain of having to face old age and make meaning of one's life. Surprisingly, he wrote the poem as a young man. METHODS: In this qualitative study, we used a hermeneutic approach to interpret Gerontion from a psychiatric perspective...
February 6, 2017: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/28168242/does-implant-design-affect-primary-stability-in-extraction-sites
#12
Matthias Karl, Ainara Irastorza-Landa
OBJECTIVE: Immediate implant placement and restoration following tooth extraction is desirable for shortening treatment times and maintaining oral structures. With a variety of bone-level implants available on the market, the goal of this in-vitro study was to compare different implant designs. METHOD AND MATERIALS: Using a polyurethane foam sandwich model with an intermediate cortical layer, a standardized extraction socket model was created. The following implant systems were assessed: OsseoSpeed EV (Astra), Straumann Bone Level Tapered (BLT), and Nobel Active (NA)...
February 6, 2017: Quintessence International
https://www.readbyqxmd.com/read/28130697/blobel-and-sabatini-s-beautiful-idea-visual-representations-of-the-conception-and-refinement-of-the-signal-hypothesis
#13
Michelle Lynne LaBonte
In 1971, Günter Blobel and David Sabatini proposed a novel and quite speculative schematic model to describe how proteins might reach the proper cellular location. According to their proposal, proteins destined to be secreted from the cell contain a "signal" to direct their release. Despite the fact that Blobel and Sabatini presented their signal hypothesis as a "beautiful idea" not grounded in experimental evidence, they received criticism from other scientists who opposed such speculation. Following the publication of the 1971 model, Blobel persisted in conducting experiments and revising the model to incorporate new data...
January 27, 2017: Journal of the History of Biology
https://www.readbyqxmd.com/read/28109526/the-threshold-vs-lnt-showdown-dose-rate-findings-exposed-flaws-in-the-lnt-model-part-1-the-russell-muller-debate
#14
REVIEW
Edward J Calabrese
This paper assesses the discovery of the dose-rate effect in radiation genetics and how it challenged fundamental tenets of the linear non-threshold (LNT) dose response model, including the assumptions that all mutational damage is cumulative and irreversible and that the dose-response is linear at low doses. Newly uncovered historical information also describes how a key 1964 report by the International Commission for Radiological Protection (ICRP) addressed the effects of dose rate in the assessment of genetic risk...
January 18, 2017: Environmental Research
https://www.readbyqxmd.com/read/28106908/the-aspirin-story-from-willow-to-wonder-drug
#15
REVIEW
Michael J R Desborough, David M Keeling
The story of the discovery of aspirin stretches back more than 3500 years to when bark from the willow tree was used as a pain reliever and antipyretic. It involves an Oxfordshire clergyman, scientists at a German dye manufacturer, a Nobel Prize-winning discovery and a series of pivotal clinical trials. Aspirin is now the most commonly used drug in the world. Its role in preventing cardiovascular and cerebrovascular disease has been revolutionary and one of the biggest pharmaceutical success stories of the last century...
January 20, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28105742/yeasts-for-global-happiness-report-of-the-14th-international-congress-on-yeasts-icy14-held-in-awaji-island
#16
Daisuke Watanabe, Hiroshi Takagi
The 14th International Congress on Yeasts (ICY14) was held at Awaji Yumebutai International Conference Center (Awaji, Hyogo) in Japan from 11 to 15 September 2016. The main slogan of ICY14 was 'Yeasts for Global Happiness', which enabled us to acknowledge the high-potential usefulness of yeasts contributing to the global happiness in terms of food/beverage, health/medicine and energy/environment industries, as well as to basic biosciences. In addition, two more concepts were introduced: 'from Japan to the world' and 'from senior to junior'...
January 20, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28098825/optical-fibre-sensors-using-graphene-based-materials-a-review
#17
REVIEW
Miguel Hernaez, Carlos R Zamarreño, Sonia Melendi-Espina, Liam R Bird, Andrew G Mayes, Francisco J Arregui
Graphene and its derivatives have become the most explored materials since Novoselov and Geim (Nobel Prize winners for Physics in 2010) achieved its isolation in 2004. The exceptional properties of graphene have attracted the attention of the scientific community from different research fields, generating high impact not only in scientific journals, but also in general-interest newspapers. Optical fibre sensing is one of the many fields that can benefit from the use of these new materials, combining the amazing morphological, chemical, optical and electrical features of graphene with the advantages that optical fibre offers over other sensing strategies...
January 14, 2017: Sensors
https://www.readbyqxmd.com/read/28098617/nobel-prize-for-anesthesia-pioneer
#18
Tyson J Olds, George R Kracke
No abstract text is available yet for this article.
February 2017: Anesthesiology
https://www.readbyqxmd.com/read/28097732/fundamental-mechanisms-deliver-the-nobel-prize-to-ohsumi
#19
Sharon A Tooze, Lisa A Hannan, Michael S Marks, Tom H Stevens, Trina A Schroer
No abstract text is available yet for this article.
February 2017: Traffic
https://www.readbyqxmd.com/read/28096414/profile-of-jean-pierre-sauvage-sir-j-fraser-stoddart-and-bernard-l-feringa-2016-nobel-laureates-in-chemistry
#20
Jonathan C Barnes, Chad A Mirkin
No abstract text is available yet for this article.
January 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
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