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https://www.readbyqxmd.com/read/28641826/the-chemical-history-of-morphine-an-8000-year-journey-from-resin-to-de-novo-synthesis
#1
Karolina Brook, Jessica Bennett, Sukumar P Desai
Evidence of human use of opium dates back as far as the sixth millennium BCE. Ancient societies through the Renaissance period created a variety of opium products, proliferating its common use and subsequent addiction. Because the active moiety was not known at this time, the potency of these opium concoctions could neither be predicted nor controlled. The first step in identifying opium's active ingredient, morphine, was its chemical isolation in the early 1800s by Wilhelm Sertürner. The subsequent elucidation of morphine's chemical formula and Sir Robert Robinson's derivation of morphine's structural formula, which won him the 1947 Nobel Prize in Chemistry, round out 150 years of the incremental advances in our chemical understanding of morphine...
April 2017: Journal of Anesthesia History
https://www.readbyqxmd.com/read/28633136/malaria-fever-therapy-for-general-paralysis-of-the-insane-a-historical-cohort-study
#2
Ingrid M Daey Ouwens, C Elisabeth Lens, Aernoud T L Fiolet, Alewijn Ott, Peter J Koehler, Piet A Kager, Willem M A Verhoeven
BACKGROUND/AIMS: This year marks the 100th anniversary of the first malaria fever treatment (MFT) given to patients with general paralysis of the insane (GPI) by the Austrian psychiatrist and later Nobel laureate, Julius Wagner-Jauregg. In 1921 Wagner-Jauregg reported an impressive therapeutic success of MFT and it became the standard treatment for GPI worldwide. In this study, MFT practice in the Dutch Vincent van Gogh psychiatric hospital in GPI patients who had been admitted in the period 1924-1954 is explored...
June 21, 2017: European Neurology
https://www.readbyqxmd.com/read/28632333/from-chemical-topology-to-molecular-machines-nobel-lecture
#3
REVIEW
Jean-Pierre Sauvage
To a large extent, the field of "molecular machines" started after several groups were able to prepare, reasonably easily, interlocking ring compounds (named catenanes for compounds consisting of interlocking rings and rotaxanes for rings threaded by molecular filaments or axes). Important families of molecular machines not belonging to the interlocking world were also designed, prepared, and studied but, for most of them, their elaboration was more recent than that of catenanes or rotaxanes. Since the creation of interlocking ring molecules is so important in relation to the molecular machinery area, we will start with this aspect of our work...
June 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28622978/the-evolution-and-nomenclature-of-gnrh-type-and-corazonin-type-neuropeptide-signaling-systems
#4
REVIEW
Meet Zandawala, Shi Tian, Maurice R Elphick
Gonadotropin-releasing hormone (GnRH) was first discovered in mammals on account of its effect in triggering pituitary release of gonadotropins and the importance of this discovery was recognized forty years ago in the award of the 1977 Nobel Prize for Physiology or Medicine. Investigation of the evolution of GnRH revealed that GnRH-type signaling systems occur throughout the chordates, including agnathans (e.g. lampreys) and urochordates (e.g. sea squirts). Furthermore, the discovery that adipokinetic hormone (AKH) is the ligand for a GnRH-type receptor in the arthropod Drosophila melanogaster provided evidence of the antiquity of GnRH-type signaling...
June 13, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28622110/pavlov-and-cajal-two-different-pathways-to-a-nobel-prize
#5
Jairo A Rozo, Yuniesky Andrade-Talavera, Antonio Rodríguez-Moreno
Ivan Pavlov (1849-1936) and Santiago Ramón y Cajal (1852-1934) were two contemporary scientists who not only had a great impact on Russian and Spanish science but also on the international stage. Both shared several common features in their life and work, yet they followed fundamentally different paths during their training as scientists. While Pavlov received his laboratory training under the guidance of Ilya Tsion (1843-1912), Cajal did not receive any formal training within a particular laboratory nor did he have a mentor in the traditional sense, rather he was mainly self-taught, although he was supported by key figures like Maestre de San Juan (1828-1890) and Luis Simarro (1851-1921)...
July 2017: Journal of the History of the Neurosciences
https://www.readbyqxmd.com/read/28621284/comparison-of-platform-switched-and-sloping-shoulder-implants-on-stress-reduction-in-various-bone-densities-finite-element-analysis
#6
Joji Markose, S Suresh, Shruthi Eshwar, K Rekha, Vipin Jain, Supriya Manvi
INTRODUCTION: Comparison of platform switched (PS), sloping shoulder, and regular implants on stress reduction in various bone densities with finite element analysis. MATERIALS AND METHODS: A total of 12 three-dimensional finite element models were built to analyze the stress distribution model. Nobel Biocare 4.3 × 8 mm regular platform replace select implant with matching diameter easy abutment, Nobel Biocare 4.3 × 8 mm replace select implant PS with 3.5 mm diameter easy abutment, Bicon 4 × 8 mm implant with 4 mm diameter sloping shoulder abutments were created virtually in compact bone density using software...
June 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28614812/the-discovery-of-water-channels-aquaporins
#7
Dennis Brown
The movement of water into and out of cells is a fundamental biological process that is essential for life. Such water movement not only regulates the activity of individual cells but also is responsible for the functioning of many organ systems and for maintaining whole body water balance. It had long been suspected that water movement across biological cell membranes was in some way enhanced or facilitated by pores or channels, but the search to identify these channels was long and tedious. As is often the case in science, the secret of the water channel was eventually discovered by chance in 1992 by Peter Agre and his colleagues at the Johns Hopkins University in Baltimore, who were working on red blood cell membrane proteins...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28612706/autophagy-and-its-link-to-type-ii-diabetes-mellitus
#8
Jai-Sing Yang, Chi-Cheng Lu, Sheng-Chu Kuo, Yuan-Man Hsu, Shih-Chang Tsai, Shih-Yin Chen, Yng-Tay Chen, Ying-Ju Lin, Yu-Chuen Huang, Chao-Jung Chen, Wei-De Lin, Wen-Lin Liao, Wei-Yong Lin, Yu-Huei Liu, Jinn-Chyuan Sheu, Fuu-Jen Tsai
Autophagy, a double-edged sword for cell survival, is the research object on 2016 Nobel Prize in Physiology or Medicine. Autophagy is a molecular mechanism for maintaining cellular physiology and promoting survival. Defects in autophagy lead to the etiology of many diseases, including diabetes mellitus (DM), cancer, neurodegeneration, infection disease and aging. DM is a metabolic and chronic disorder and has a higher prevalence in the world as well as in Taiwan. The character of diabetes mellitus is hyperglycemia resulting from defects in insulin secretion, insulin action, or both...
June 2017: BioMedicine
https://www.readbyqxmd.com/read/28612648/recovery-of-phosphorous-from-industrial-waste-water-by-oxidation-and-precipitation
#9
Rikard Ylmén, Anna M K Gustafsson, Caterina Camerani-Pinzani, Britt-Marie Steenari
This paper describes the development of a method for recovery of phosphorous from one of the waste waters at an Akzo Nobel chemical plant in Ale close to Göteborg. It was found that it is possible to transform the phosphorous in the waste water to a saleable product, i.e. a slowly dissolving fertiliser. The developed process includes oxidation of phosphite to phosphate with hydrogen peroxide and heat. The phosphate is then precipitated as crystalline struvite (ammonium magnesium phosphate) by addition of magnesium chloride...
June 14, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28603953/the-nobel-prized-cellular-target-autophagy-in-eye-diseases
#10
EDITORIAL
Kai Kaarniranta, Goran Petrovski, Anu Kauppinen
No abstract text is available yet for this article.
June 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28596628/identification-of-successful-mentoring-communities-using-network-based-analysis-of-mentor-mentee-relationships-across-nobel-laureates
#11
Julia H Chariker, Yihang Zhang, John R Pani, Eric C Rouchka
Skills underlying scientific innovation and discovery generally develop within an academic community, often beginning with a graduate mentor's laboratory. In this paper, a network analysis of doctoral student-dissertation advisor relationships in The Academic Family Tree indicates the pattern of Nobel laureate mentoring relationships is non-random. Nobel laureates had a greater number of Nobel laureate ancestors, descendants, mentees/grandmentees, and local academic family, supporting the notion that assortative processes occur in the selection of mentors and mentees...
2017: Scientometrics
https://www.readbyqxmd.com/read/28592501/a-physicist-s-quest-in-biology-max-delbr%C3%A3-ck-and-complementarity
#12
Bernard S Strauss
Max Delbrück was trained as a physicist but made his major contribution in biology and ultimately shared a Nobel Prize in Physiology or Medicine. He was the acknowledged leader of the founders of molecular biology, yet he failed to achieve his key scientific goals. His ultimate scientific aim was to find evidence for physical laws unique to biology: so-called "complementarity." He never did. The specific problem he initially wanted to solve was the nature of biological replication but the discovery of the mechanism of replication was made by others, in large part because of his disdain for the details of biochemistry...
June 2017: Genetics
https://www.readbyqxmd.com/read/28582711/biomedical-applications-of-green-synthesized-nobel-metal-nanoparticles
#13
Zia Ul Haq Khan, Amjad Khan, Yongmei Chen, Noor S Shah, Nawshad Muhammad, Arif Ullah Khan, Kamran Tahir, Faheem Ullah Khan, Behzad Murtaza, Sadaf Ul Hassan, Saeed Ahmad Qaisrani, Pingyu Wan
Synthesis of Nobel metal nanoparticles, play a key role in the field of medicine. Plants contain a substantial number of organic constituents, like phenolic compounds and various types of glycosides that help in synthesis of metal nanoparticles. Synthesis of metal nanoparticles by green method is one of the best and environment friendly methods. The major significance of the green synthesis is lack of toxic by-products produced during metal nanoparticle synthesis. The nanoparticles, synthesized by green method show various significant biological activities...
May 27, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28578578/synthesis-of-gold-nanoparticles-from-au-i-ions-shuttle-to-solidify-application-on-the-sensor-array-design
#14
Yumin Leng, Kai Jiang, Wentai Zhang, Yuhui Wang
Metal-mediated interlocking rings won the 2016 Nobel Prize in Chemistry. The metal-directed interlocking rings in macromolecular systems (e.g. proteins) may be similar to the form of Maxwell's electromagnetic waves, the metal ions may shuttle among the rings in the special environment. To verify this hypothesis, we designed a general approach to synthesize the multicolor gold nanoparticles (GNPs) mediated by Au(I)-directed interlocking rings in proteins. The Au(I) ions shuttled among these interlocking rings in the strong alkaline solution...
June 5, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28578038/particle-formation-induced-by-sonication-during-yogurt-fermentation-impact-of-exopolysaccharide-producing-starter-cultures-on-physical-properties
#15
Adrian Körzendörfer, Stefan Nöbel, Jörg Hinrichs
Two major quality defects of yogurt are syneresis and the presence of large particles, and several reasons have been extensively discussed. Vibrations during fermentation, particularly generated by pumps, must be considered as a further cause as latest research showed that both ultrasound and low frequencies induced visible particles. The aim of this study was to investigate the impact of sonication during fermentation with starter cultures differing in exopolysaccharide (EPS) synthesis on the physical properties of set (syneresis, firmness) and stirred yogurt (large particles, laser diffraction, rheology)...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28572896/how-molecular-motors-work-insights-from-the-molecular-machinist-s-toolbox-the-nobel-prize-in-chemistry-2016
#16
REVIEW
R D Astumian
The Nobel prize in Chemistry for 2016 was awarded to Jean Pierre Sauvage, Sir James Fraser Stoddart, and Bernard (Ben) Feringa for their contributions to the design and synthesis of molecular machines. While this field is still in its infancy, and at present there are no commercial applications, many observers have stressed the tremendous potential of molecular machines to revolutionize technology. However, perhaps the most important result so far accruing from the synthesis of molecular machines is the insight provided into the fundamental mechanisms by which molecular motors, including biological motors such as kinesin, myosin, FoF1 ATPase, and the flagellar motor, function...
February 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28569453/prosthetic-complications-of-different-manufacturers-in-implant-supported-restorations-with-a-minimum-of-5-years-follow-up-systematic-literature-review
#17
Stefano Storelli, Massimo Scanferla, Giulia Palandrani, Daniela Mosca, Eugenio Romeo
INTRODUCTION: Prosthetic complications on implant supported restorations have been documented in several papers published in the literature. Several manufacturers are present on the market but results are often cumulated and may mislead the reader. The objective of the present review is to assess the prosthetic complications of implants supported restorations with particular interest of the results obtained by different manufacturers. EVIDENCE ACQUISITION: A Medline-pubmend and manual search were carried out up to June 2016, leading to 6832 articles that were narrowed to 1450 titles, then 347 abstract to include 55 papers after full text reading...
May 31, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28559310/disparate-foundations-of-scientists-policy-positions-on-contentious-biomedical-research
#18
Achim Edelmann, James Moody, Ryan Light
What drives scientists' position taking on matters where empirical answers are unavailable or contradictory? We examined the contentious debate on whether to limit experiments involving the creation of potentially pandemic pathogens. Hundreds of scientists, including Nobel laureates, have signed petitions on the debate, providing unique insights into how scientists take a public stand on important scientific policies. Using 19,257 papers published by participants, we reconstructed their collaboration networks and research specializations...
June 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28555208/comparison-of-immediately-loaded-flapless-placed-one-piece-implants-and-flapped-placed-conventionally-loaded-two-piece-implants-both-fitted-with-all-ceramic-single-crowns-%C3%A2-in-the-posterior-mandible-3-year-results-from-%C3%A2-a-randomised-controlled-pilot-trial
#19
Wolfgang Bömicke, Olaf Gabbert, Andreas Koob, Johannes Krisam, Peter Rammelsberg
PURPOSE: To compare outcomes for immediately loaded one-piece implants (OPI), placed flapless, and conventionally loaded two-piece implants (TPI), placed after two-stage flapped surgery. MATERIALS AND METHODS: Thirty-eight participants were randomised to receive either one OPI (19 participants, OPI group) or one TPI (19 participants, TPI group) inserted in the posterior mandible with a torque of at least 35 Ncm according to a parallel group design. OPI were immediately loaded with non-occluding temporary crowns...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28530842/the-past-present-and-future-of-gene-therapy-from-nobel-laureate-david-baltimore
#20
James M Wilson
No abstract text is available yet for this article.
June 2017: Human Gene Therapy. Clinical Development
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