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Chunyan Li, Malinda E C Fitzgerald, Nobel Del Mar, Anton Reiner
Preganglionic parasympathetic neurons of the ventromedial part of the superior salivatory nucleus (SSN) mediate vasodilation of orbital and choroidal blood vessels, via their projection to the nitrergic pterygopalatine ganglion (PPG) neurons that innervate these vessels. We recently showed that the baroresponsive part of the nucleus of the solitary tract (NTS) innervates choroidal control parasympathetic preganglionic neurons of SSN in rats. As this projection provides a means by which blood pressure (BP) signals may modulate choroidal blood flow (ChBF), we investigated if activation of baroresponsive NTS evokes ChBF increases in rat eye, using Laser Doppler Flowmetry (LDF) to measure ChBF transclerally...
2016: Frontiers in Neuroanatomy
Stefan Hohmann
No abstract text is available yet for this article.
October 20, 2016: FEMS Yeast Research
Wei Bu, Huiling Ren, Yunping Deng, Nobel Del Mar, Natalie M Guley, Bob M Moore, Marcia G Honig, Anton Reiner
We have previously reported that mild TBI created by focal left-side cranial blast in mice produces widespread axonal injury, microglial activation, and a variety of functional deficits. We have also shown that these functional deficits are reduced by targeting microglia through their cannabinoid type-2 (CB2) receptors using 2-week daily administration of the CB2 inverse agonist SMM-189. CB2 inverse agonists stabilize the G-protein coupled CB2 receptor in an inactive conformation, leading to increased phosphorylation and nuclear translocation of the cAMP response element binding protein (CREB), and thus bias activated microglia from a pro-inflammatory M1 to a pro-healing M2 state...
2016: Frontiers in Neuroscience
David A Leigh
In the beginning…: The Nobel Prize in Chemistry 2016 goes to three of the pioneers of the field of synthetic molecular machines, Jean-Pierre Sauvage, Sir J. Fraser Stoddart, and Ben L. Feringa. Their work has led from the reliable synthesis of rotaxanes and catenanes to molecular rotary motors, shuttles, muscles, and other devices.
October 20, 2016: Angewandte Chemie
Armando Lopes, Paulo Maló, Miguel de Araújo Nobre, Elena Sánchez-Fernández, Inês Gravito
BACKGROUND: There is a necessity of studies documenting the long-term outcome of full-arch flapless rehabilitations. PURPOSE: To evaluate the 7 years implant and prosthesis survival rate and 5-years marginal bone loss of full-arch fixed prosthetic rehabilitations supported by implants in immediate function with the All-on-4(®) treatment concept using a computer guided surgical protocol (NobelGuide(®) , Nobel Biocare). MATERIALS AND METHODS: This retrospective clinical study included 111 edentulous patients (n = 53 bruxers; n = 21 smokers; n = 59 systemically compromised), rehabilitated between February 2005 and November 2010 with 532 implants with the All-on-4(®) treatment concept using NobelGuide(®) ...
October 18, 2016: Clinical Implant Dentistry and related Research
Takeshi Ohkuma
No abstract text is available yet for this article.
October 17, 2016: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
Yoko Yamaguchi, Makoto Shiota, Motohiro Munakata, Shohei Kasugai, Masahiko Ozeki
BACKGROUND: Primary stability following implant placement is essential for osseointegration and is affected by both implant design and bone density. The aim of this study was to compare the relationships between torque-time curves and implant designs in a poor bone quality model. METHODS: Nine implant designs, with five implants in each category, were compared. A total of 90 implants (Straumann: Standard RN, Bone Level RC, Tapered Effect RN; Nobel Biocare: Brånemark MKIII, MKIV) were placed in type IV artificial bone...
December 2015: Int J Implant Dent
Lidia Pino, Cristina Italiano, Antonio Vita, Concetto Fabiano, Vincenzo Recupero
Sorbents for CO2 capture have been prepared by wet impregnation of a commercial active carbon (Ketjen-black, Akzo Nobel) with two CO2-philic compounds, polyethylenimine (PEI) and tetraethylenepentamine (TEPA), respectively. The effects of amine amount (from 10 to 70wt.%), CO2 concentration in the feed, sorption temperature and gas hourly space velocity on the CO2 capture performance have been investigated. The sorption capacity has been evaluated using the breakthrough method, with a fixed bed reactor equipped with on line gas chromatograph...
October 2016: Journal of Environmental Sciences (China)
Robert F Service
No abstract text is available yet for this article.
October 14, 2016: Science
Richard Van Noorden, Davide Castelvecchi
No abstract text is available yet for this article.
October 5, 2016: Nature
Tom Clynes
No abstract text is available yet for this article.
October 7, 2016: Nature
Stephen R Adams
Roger Y. Tsien, professor at the University of California, San Diego and Howard Hughes Medical Institute Investigator, passed away on August 24, 2016. Tsien shared the 2008 Nobel Prize in Chemistry for his work on the discovery and development of the green fluorescent protein, and developed a whole series of colored fluorescent proteins, as well as widely used small-molecule probes for Ca(2+) ions.
October 12, 2016: Angewandte Chemie
Nicholas J Maness
Decades of research, including the 1996 Nobel Prize in Medicine, confirm the evolutionary and immunological importance of CD8 T lymphocytes (TCD8+) that target peptides bound by the highly variable major histocompatibility complex class I (MHC-I) proteins. However, their perceived importance has varied dramatically over the past decade. Regardless, there remains myriad reasons to consider the diversity of MHC-I alleles and the TCD8+ that target them as enormously important in infectious disease research. Thus, understanding these molecules in the best animal models of human disease could be a necessity for optimizing the translational potential of these models...
October 11, 2016: Toxicologic Pathology
Irina Odnoletkova, Dirk Ramaekers, Frank Nobels, Geert Goderis, Bert Aertgeerts, Lieven Annemans
BACKGROUND: People with diabetes have a high risk of developing micro- and macrovascular complications associated with diminished life expectancy and elevated treatment costs. Patient education programs can improve diabetes control in the short term, but their cost-effectiveness is uncertain. Our study aimed to analyze the lifelong cost-effectiveness of a nurse-led telecoaching program compared to usual care in people with type 2 diabetes from the perspective of the Belgian healthcare system...
2016: PloS One
Sutapa Khatua, Abby M Geltemeyer, Anand Gourishankar
Robert Heinrich Herman Koch, a German physician and microbiologist, received Nobel Prize in 1905 for identifying the specific causative agent of Tuberculosis. During his time it was believed that TB was an inherited disease. However he was convinced that the disease was caused by a bacterium and was infectious, tested his postulates using guinea pigs, and found the causative agent to be slow growing Mycobacterium Tuberculosis.TB is the second most common cause of death from infectious diseases after HIV/AIDS...
October 10, 2016: Pediatric Research
Merle Hantsche, Patrick Cramer
Transcription is the first step in expression of the genetic information in all living cells. The regulation of transcription underlies cell differentiation, organism development, and responses of living systems to changes in the environment. During transcription, the enzyme RNA polymerase uses DNA as a template to synthesize a complementary RNA copy from a gene. Here we summarize the progress in our understanding of the structural basis of eukaryotic gene transcription that has been made ten years after the Nobel Prize in Chemistry given to Roger Kornberg in 2006...
October 10, 2016: Angewandte Chemie
Pietro Felice, Giovanni Zucchelli, Gioacchino Cannizzaro, Carlo Barausse, Michele Diazzi, Anna Trullenque-Eriksson, Marco Esposito
PURPOSE: To compare the clinical outcome of single implants placed immediately after tooth extraction with implants placed 6 weeks after tooth extraction (immediate-delayed placement), and with implants placed after 4 months of extraction and socket healing (delayed placement). MATERIALS AND METHODS: Two hundred and ten patients requiring a single implant-supported crown to replace a tooth to be extracted were randomised to receive immediate post-extractive implants (70 patients), immediate-delayed implants at 6 weeks (70 patients), and delayed implants after 4 months of healing (70 patients), according to a parallel group design...
2016: European Journal of Oral Implantology
Dara Mohammadi
No abstract text is available yet for this article.
October 15, 2016: Lancet
J Aznar, J Tudela
On the 10-year anniversary of the discovery of induced pluripotent stem cells, we review the main results from their various fields of application, the obstacles encountered during experimentation and the potential applications in clinical practice. The efficacy of induced pluripotent cells in clinical experimentation can be equated to that of human embryonic stem cells; however, unlike stem cells, induced pluripotent cells do not involve the severe ethical difficulties entailed by the need to destroy human embryos to obtain them...
October 4, 2016: Revista Clínica Española
Jun Li, Dajeong Yim, Woo-Dong Jang, Juyoung Yoon
Crown ethers, discovered by the winner of the Nobel Prize Charles Pedersen, are cyclic chemical compounds that consist of a ring or multiple rings containing several ether groups that are capable of binding alkali ions. A smart fluorescent probe containing a crown ether moiety could be developed as a sensor for metal ions, anions and other bio-molecules and be further applied to monitor the relevant biological process in vivo. This review highlights recent advances which can be divided into seven parts: (i) fluorescent probes containing a simple crown ether or an aza-crown ether structure; (ii) fluorescent probes containing an azathia crown ether; (iii) fluorescent probes containing a cryptand; (iv) fluorescent probes containing two or more binding sites; (v) crown ether derivatives-metal complex assisted chemosensing of bioactive species; (vi) crown ether-based chemosensors for bioactive molecular detection; and (vii) efforts to improve biological relevance...
September 26, 2016: Chemical Society Reviews
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