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https://www.readbyqxmd.com/read/29455189/is-it-time-to-abandon-the-nobel-prize
#1
EDITORIAL
Clare Fiala, Eleftherios P Diamandis
No abstract text is available yet for this article.
February 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29442038/non-viral-gene-delivery-systems-hurdles-for-bench-to-bedside-transformation
#2
N A Helal, A Osami, A Helmy, T McDonald, L A Shaaban, M I Nounou
Biologist and Nobel Prize winner James Watson's quote, "We used to think that our fate was in our stars, but now we know that, in large measure, our fate is in our genes", represents the initial food for thought that revolutionized the way medications and active pharmaceutical ingredients are defined (Rocholl 1996). This fate engraved in the genetic material, as mentioned in Watson's quote, fueled a tremendous revolution wave in gene therapy. Gene therapy is a promising technology for treating genetic and acquired diseases by modulating the expression of a specific gene in the pathological cells...
November 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29428046/the-bethesda-classification-for-thyroid-fine-needle-aspiration-a-predictor-or-an-alarmist
#3
John D Galbraith, Noah Swann, Brian Cox, Nobel LeTendre, James Recabaren
Thyroid malignancies comprise only 2 per cent of all cancers. Yet the incidence of thyroid cancers has been increasing faster than other malignancies, likely due to increased screening and surveillance of thyroid nodules. The Bethesda system represents the preferred method of evaluating thyroid nodules for malignancy using fine needle aspiration (FNA). Many thyroidectomies are performed for small, asymptomatic nodules found on ultrasound. These small papillary cancers (<0.5 cm) are termed microcarcinomas and represent a more indolent natural history causing some to name them "occult papillary tumors...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29426786/effect-of-feldspathic-porcelain-layering-on-the-marginal-fit-of-zirconia-and-titanium-complete-arch-fixed-implant-supported-frameworks
#4
Burak Yilmaz, Faris A Alshahrani, Ediz Kale, William M Johnston
STATEMENT OF PROBLEM: Veneering with porcelain may adversely affect the marginal fit of long-span computer-aided design and computer-aided manufacturing (CAD-CAM) implant-supported fixed prostheses. Moreover, data regarding the precision of fit of CAD-CAM-fabricated implant-supported complete zirconia fixed dental prostheses (FDPs) before and after porcelain layering are limited. PURPOSE: The purpose of this in vitro study was to evaluate the effect of porcelain layering on the marginal fit of CAD-CAM-fabricated complete-arch implant-supported, screw-retained FDPs with presintered zirconia frameworks compared with titanium...
February 6, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29423601/the-2017-nobel-prize-in-chemistry-cryo-em-comes-of-age
#5
Peter S Shen
The 2017 Nobel Prize in Chemistry was awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson for "developing cryo-electron microscopy (cryo-EM) for the high-resolution structure determination of biomolecules in solution." This feature article summarizes some of the major achievements leading to the development of cryo-EM and recent technological breakthroughs that have transformed the method into a mainstream tool for structure determination.
February 9, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29422456/an-introduction-to-optical-super-resolution-microscopy-for-the-adventurous-biologist
#6
Jeroen Vangindertael, Rafael Camacho, Wouter Sempels, Hideaki Mizuno, Peter Dedecker, Kris Pieter Frans P F Janssen
Ever since the inception of light microscopy, the laws of physics have seemingly thwarted every attempt to visualize the processes of life at its most fundamental, sub- cellular, level. The diffraction limit has restricted our view to length scales well above 250 nm and in doing so, severely compromised our ability to gain true insights into many biological systems. Fortunately, continuous advancements in optics, electronics and mathematics have since provided the means to once again make physics work to our advantage...
February 9, 2018: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/29421790/edgar-adrian-1889-1977-and-shell-shock-electrotherapy-a-forgotten-history
#7
Laurent Tatu
The English electrophysiologist Edgar Adrian (1889-1977) was the recipient of the Nobel Prize for physiology in 1932 for his research on the functions of neurons. During World War I, at Queen Square in London, he devised an intensive electrotherapeutic treatment for shell-shocked soldiers. The procedure, developed with Lewis Yealland (1884-1954), was similar to "torpillage," the faradic psychotherapy used in France. Adrian and Yealland considered that the pain accompanying the use of faradic current was necessary for both therapeutic and disciplinary reasons, especially because of the suspicion of malingering...
February 8, 2018: European Neurology
https://www.readbyqxmd.com/read/29411208/stool-pcr-for-gastrointestinal-pathogens-in-patients-with-and-without-immune-mediated-intestinal-diseases
#8
Yael R Nobel, Jordan Axelrad, Suzanne K Lewis, Susan Whittier, Garrett Lawlor, Simon Lichtiger, Peter H R Green, Benjamin Lebwohl
BACKGROUND: Patients with celiac disease and inflammatory bowel disease, two immune-mediated luminal conditions, have higher rates of certain infections than healthy counterparts. The prevalence of many gastrointestinal infections in these patients, however, is unknown. AIMS: Using a novel clinical stool pathogen PCR test, we investigated the hypothesis that patients with celiac disease/inflammatory bowel disease had different distributions of diarrheal pathogens than other patients...
February 6, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29400101/-nobel-prize-for-the-discoveries-of-genetic-mechanisms-controlling-the-circadian-rythm
#9
László Maródi
No abstract text is available yet for this article.
February 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29389549/stem-cell-therapy-on-skin-mechanisms-recent-advances-and-drug-reviewing-issues
#10
REVIEW
Gong-Yau Chu, Yu-Fu Chen, Hsiao-Yun Chen, Ming-Hsiao Chan, Churn-Shiouh Gau, Shih-Ming Weng
Stem cell products and its clinical applications have been widely discussed in recent years, particularly when the Japanese "induced pluripotent stem cells" founder Dr. Yamanaka was awarded as Nobel Prize laureate in 2013. For decades, major progresses have been achieved in the stem cell biology field, and more and more evidence showed that skin stem cells are involved in the process of skin repair. Stem/progenitor cells of the epidermis are recognized to play the most essential role in the tissue regeneration of skin...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29381253/accuracy-and-precision-of-flash-glucose-monitoring-sensors-inserted-into-the-abdomen-and-upper-thigh-compared-to-the-upper-arm-out-of-sight
#11
Sara Charleer, Chantal Mathieu, Frank Nobels, Pieter Gillard
Nowadays, most Belgian patients with type 1 diabetes use flash glucose monitoring (FreeStyle® Libre™ [FSL]) to check their glucose values, but some patients find the sensor on the upper arm too visible. The aim of this study was to compare accuracy and precision of FSL sensors when placed on different sites. Twenty-three adults with type 1 diabetes used three FSL sensors simultaneously for 14 days on upper arm, abdomen, and upper thigh. FSL measurements were compared to capillary blood glucose (BG) measurements obtained with built-in FSL BG meter...
January 30, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29377580/bringing-european-physiologists-together
#12
EDITORIAL
Peter Bie, Ralf Brandes, Susan Deuchars, David Eisner, Joachim Fandrey, Markus Hecker, William Louch, Tomi Taira, Bayram Yilmaz
The modern science of physiology began in Europe. Deciding on exactly who the first physiologist was is not easy but excellent candidates include Claude Bernard and Carl Ludwig. The Nobel Prize in Physiology or Medicine was inaugurated in 1901 with the first award mentioning the word "physiology" being made to Ivan Pavlov (Russia) in 1904. This article is protected by copyright. All rights reserved.
January 29, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29373128/early-stages-in-the-history-of-gas-chromatography
#13
Ivan G Kolomnikov, Alexander M Efremov, Tatyana I Tikhomirova, Nadezhda M Sorokina, Yury A Zolotov
The creation of gas chromatography is traditionally associated with the names of Nobel Prize winner Archer Martin and his colleagues Richard Synge and Anthony James. However, sometimes references to their predecessors can be found. An investigation conducted by the authors of this article not only confirmed the reliability of these references; but in fact led to the conclusion that by 1952, which is commonly believed to be the year when gas chromatography was born, many research papers had already been devoted to this method, mainly, in its gas-solid version...
January 3, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29372074/jules-gonin-and-the-nobel-prize-pioneer-of-retinal-detachment-surgery-who-almost-received-a-nobel-prize-in-medicine
#14
Fábio Barreto Morais
No abstract text is available yet for this article.
2018: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/29367188/chronobiology-2017-nobel-prize-in-physiology-or-medicine
#15
Li Yuan, Yi-Rou Li, Xiao-Dong Xu
Chronobiology is a field of biology that examines the generation of biological rhythms in various creatures and in many parts of body, and their adaptive fitness to solar- and lunar-related periodic phenomena. The synchronization of internal circadian clocks with external timing signals confers accurate phase response and tissue homeostasis. Herein we state a series of studies on circadian rhythms and introduce the brief history of chronobiology. We also present a detailed timeline of the discoveries on molecular mechanisms controlling circadian rhythm in Drosophila, which was awarded the 2017 Nobel Prize in Physiology or Medicine...
January 20, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29354840/electrochemical-processes-on-solid-shaped-nanoparticles-with-defined-facets
#16
REVIEW
Peter Strasser, Manuel Gliech, Stefanie Kuehl, Tim Moeller
This 2007 Chemistry Nobel prize update covers scientific advances of the past decade in our understanding of electrocatalytic processes on surfaces of nanoscale shape-controlled polyhedral solids. It is argued that the field of chemical reaction processes on solid surfaces has recently been paying increasing attention to the fundamental understanding of electrified solid-liquid interfaces and toward the operando study of the minute fraction of catalytically active, structurally dynamic non-equilibrium Taylor-type surface sites...
January 22, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29353498/-family-tree-of-george-von-b%C3%A3-k%C3%A3-sy-the-nobel-prized-hungarian-researcher
#17
János Vincze
No abstract text is available yet for this article.
January 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29344776/dawning-of-a-new-era-in-trp-channel-structural-biology-by-cryo-electron-microscopy
#18
REVIEW
M Gregor Madej, Christine M Ziegler
Cryo-electron microscopy (cryo-EM) permits the determination of atomic protein structures by averaging large numbers of individual projection images recorded at cryogenic temperatures-a method termed single-particle analysis. The cryo-preservation traps proteins within a thin glass-like ice layer, making literally a freeze image of proteins in solution. Projections of randomly adopted orientations are merged to reconstruct a 3D density map. While atomic resolution for highly symmetric viruses was achieved already in 2009, the development of new sensitive and fast electron detectors has enabled cryo-EM for smaller and asymmetrical proteins including fragile membrane proteins...
January 17, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29344005/biological-clocks-their-relevance-to-immune-allergic-diseases
#19
REVIEW
Roberto Paganelli, Claudia Petrarca, Mario Di Gioacchino
The 2017 Nobel Prize for Physiology or Medicine, awarded for the discoveries made in the past 15 years on the genetic and molecular mechanisms regulating many physiological functions, has renewed the attention to the importance of circadian rhythms. These originate from a central pacemaker in the suprachiasmatic nucleus in the brain, photoentrained via direct connection with melanopsin containing, intrinsically light-sensitive retinal ganglion cells, and it projects to periphery, thus creating an inner circadian rhythm...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29342264/effect-of-continuous-glucose-monitoring-on-glycemic-control-acute-admissions-and-quality-of-life-a-real-world-study
#20
Sara Charleer, Chantal Mathieu, Frank Nobels, Christophe De Block, Regis P Radermecker, Michel P Hermans, Youri Taes, Chris Vercammen, Guy T'Sjoen, Laurent Crenier, Steffen Fieuws, Bart Keymeulen, Pieter Gillard
Context: Randomized controlled trials evaluating real-time continuous glucose monitoring (RT-CGM) patients with type 1 diabetes (T1D) show improved glycemic control, but limited data are available on real-world use. Objective: To assess impact of RT-CGM in real-world settings on glycemic control, hospital admissions, work absenteeism and quality of life (QOL). Design: Prospective, observational, multicenter, cohort study. Participants: Five hundred fifteen adults with T1D on continuous subcutaneous insulin infusion (CSII) therapy starting in the Belgian RT-CGM reimbursement program...
January 12, 2018: Journal of Clinical Endocrinology and Metabolism
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