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https://www.readbyqxmd.com/read/28335417/dna-sequencing-sensors-an-overview
#1
REVIEW
Jose Antonio Garrido-Cardenas, Federico Garcia-Maroto, Jose Antonio Alvarez-Bermejo, Francisco Manzano-Agugliaro
The first sequencing of a complete genome was published forty years ago by the double Nobel Prize in Chemistry winner Frederick Sanger. That corresponded to the small sized genome of a bacteriophage, but since then there have been many complex organisms whose DNA have been sequenced. This was possible thanks to continuous advances in the fields of biochemistry and molecular genetics, but also in other areas such as nanotechnology and computing. Nowadays, sequencing sensors based on genetic material have little to do with those used by Sanger...
March 14, 2017: Sensors
https://www.readbyqxmd.com/read/28328672/pediatric-trauma-under-triage-in-ohio
#2
Juan P Gurria, Lynn Haas, Md Monir Hossain, Mohammad Alfrad Nobel Bhuiyan, Misty Troutt, Suzanne Moody, Richard A Falcone
BACKGROUND: Appropriate and timely triage is an essential component of a trauma system. In the state of Ohio there are 6 verified pediatric trauma centers (PTC) across 8 state regions. The purpose of this study was to better understand the pediatric under-triage rates in the state. METHODS: We utilized the Ohio Trauma Registry from 2007 - 2012, consisting of 14,045 records of children < 16 years admitted to a hospital for greater than 48 hours or who sustained a traumatic death...
March 20, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28327697/seven-mm-long-dental-implants-in-posterior-jaws-3-year-report-of-an-ongoing-prospective-single-cohort-study
#3
Paulo Maló, Miguel de Araújo Nobre, Armando Lopes, Inês Gonçalves, Mariana Nunes
PURPOSE: To report on the outcome of 7 mm long implants in the rehabilitation of posterior areas of atrophic jaws 3 years after loading. MATERIALS AND METHODS: This prospective study included 127 patients treated with 217 implants supporting 165 fixed prostheses. Final abutments were delivered at surgery stage and in the large majority of patients (n = 116) the implants (n = 199) were loaded after 4 months. Primary outcome measures were implant success and prosthetic success calculated at patient level; secondary outcome measures were complications, and marginal bone level changes calculated at patient level...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28327692/immediate-immediate-delayed-6%C3%A2-weeks-and-delayed-4%C3%A2-months-post-extractive-single-implants-1-year-post-loading-data-from-a-randomised-controlled-trial
#4
Marco Esposito, Giovanni Zucchelli, Gioacchino Cannizzaro, Luigi Checchi, Carlo Barausse, Anna Trullenque-Eriksson, Pietro Felice
PURPOSE: To compare the clinical outcome of single implants placed immediately after tooth extraction with implants placed 6 weeks after tooth extraction (immediate-delayed placement), and with implants placed after 4-month extraction and socket healing (delayed placement). MATERIALS AND METHODS: Two-hundred and ten (210) patients requiring a single implant-supported crown to replace a tooth to be extracted were randomised to receive immediate post-extractive implants (70 patients), immediate-delayed implants at 6 weeks (70 patients), and delayed implants after 4 months of healing (70 patients) according to a parallel group design...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28317831/-conceptual-approach-to-classification-of-implant-supported-prosthesis-for-edentulous-patients
#5
V N Trezubov, R A Rozov, G S Azarin
The aim of this study was the creation of a conceptual model of the standard implant prosthetics for edentulous patients using the data of comprehensive examination and implantation prosthetics in 372 patients aged 38 to 80 years (201 women, 171 men) with 582 implant supported prosthesis of various types, supporting on implants «Nobel Replace Select/Groove» and «Nobel Speedy Groove» (3675 implants). Clinical classification of implant-supported prosthesis for edentulous patients included 5 classes: class 1 (1-2 implants) included 6...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28317053/practical-applications-of-supramolecular-chemistry
#6
Igor V Kolesnichenko, Eric V Anslyn
This year marks the 50th anniversary of Charles Pedersen's discovery of crown ethers, what is widely considered the birth of supramolecular chemistry. Since then, the field has progressed greatly, winning two Nobel Prizes and seeing the implementation of many practical applications. In commemoration, we are exploring the more recent advances of the field, which have made it past the realm of chemistry, into the real world. Though not a comprehensive review, the topics that we discuss here are supramolecular sensors, imaging for medical applications, metal extraction from ores and nuclear waste, as well as drug delivery...
March 20, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28299272/three-dimensional-planning-in-craniomaxillofacial-surgery
#7
Josep Rubio-Palau, Alejandra Prieto-Gundin, Asteria Albert Cazalla, Miguel Bejarano Serrano, Gemma Garcia Fructuoso, Francisco Parri Ferrandis, Alejandro Rivera Baró
INTRODUCTION: Three-dimensional (3D) planning in oral and maxillofacial surgery has become a standard in the planification of a variety of conditions such as dental implants and orthognathic surgery. By using custom-made cutting and positioning guides, the virtual surgery is exported to the operating room, increasing precision and improving results. MATERIALS AND METHODS: We present our experience in the treatment of craniofacial deformities with 3D planning. Software to plan the different procedures has been selected for each case, depending on the procedure (Nobel Clinician, Kodak 3DS, Simplant O&O, Dolphin 3D, Timeus, Mimics and 3-Matic)...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28288477/intraoperative-bleeding-and-the-risk-of-residual-cholesteatoma-a-multivariate-analysis
#8
Gavin J le Nobel, Sharon L Cushing, Blake C Papsin, Adrian L James
OBJECTIVE: Residual cholesteatoma most frequently occurs where visualization and surgical access are restricted by anatomic constraints. Other factors that compromise surgical field visualization might also increase rates of residual cholesteatoma. We evaluated whether impaired surgical field clarity from bleeding increases rates of residual cholesteatoma. STUDY DESIGN: Prospective cohort study. SETTING: Tertiary care hospital. PATIENTS: Consecutive series of children having intact canal wall surgery for cholesteatoma...
April 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28285851/ivermectin-old-drug-new-tricks
#9
REVIEW
Roz Laing, Victoria Gillan, Eileen Devaney
Ivermectin is one of the most important drugs in veterinary and human medicine for the control of parasitic infection and was the joint focus of the 2015 Nobel Prize in Physiology or Medicine, some 35 years after its remarkable discovery. Although best described for its activity on glutamate-gated chloride channels in parasitic nematodes, understanding of its mode of action remains incomplete. In the field of veterinary medicine, resistance to ivermectin is now widespread, but the mechanisms underlying resistance are unresolved...
March 9, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28282087/-media-narrative-and-scientific-research
#10
María López Geist
The transmission of the scientific knowledge poses the question of the diversity of academic publications and stakeholders. Emphasis is placed on the relationship between scientific researchers and science journalists, and some issues that both handle with legitimate but different criteria are discussed. The complexity of the narrative in the discourse of science is evidenced when uncertainty and controversy take place. Some well-known bogus scientific stories in the media, such as Andrew Wakefield, Hwang Woo Suk and John Bohannon illustrate the role of the media and the factors of power in the social construction of knowledge...
July 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28279189/therapeutic-strategies-of-drug-repositioning-targeting-autophagy-to-induce-cancer-cell-death-from-pathophysiology-to-treatment
#11
REVIEW
Go J Yoshida
The 2016 Nobel Prize in Physiology or Medicine was awarded to the researcher that discovered autophagy, which is an evolutionally conserved catabolic process which degrades cytoplasmic constituents and organelles in the lysosome. Autophagy plays a crucial role in both normal tissue homeostasis and tumor development and is necessary for cancer cells to adapt efficiently to an unfavorable tumor microenvironment characterized by hypo-nutrient conditions. This protein degradation process leads to amino acid recycling, which provides sufficient amino acid substrates for cellular survival and proliferation...
March 9, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28270807/the-autophagic-machinery-in-viral-exocytosis
#12
REVIEW
Christian Münz
The discovery of the molecular machinery of autophagy, namely Atg proteins, was awarded with the Nobel prize in physiology and medicine to Yoshinori Ohsumi in 2016. While this machinery was originally identified by its ability to allow cells to survive starvation via lysosomal degradation to recycle cellular components, it has recently become apparent that it also is used by cells to secrete cytoplasmic constituents. Furthermore, viruses have learned to use this Atg supported exocytosis to exit cells, acquire envelopes in the cytosol and select lipids into their surrounding membranes that might allow for increased robustness of their virions and altered infection behavior...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28262598/effectiveness-and-cost-effectiveness-of-a-nurse-delivered-intervention-to-improve-adherence-to-treatment-for-hiv-a-pragmatic-multicentre-open-label-randomised-clinical-trial
#13
Marijn de Bruin, Edwin J M Oberjé, Wolfgang Viechtbauer, Hans-Erik Nobel, Mickaël Hiligsmann, Cees van Nieuwkoop, Jan Veenstra, Frank J Pijnappel, Frank P Kroon, Laura van Zonneveld, Paul H P Groeneveld, Marjolein van Broekhuizen, Silvia M A A Evers, Jan M Prins
BACKGROUND: No high-quality trials have provided evidence of effectiveness and cost-effectiveness of HIV treatment adherence intervention strategies. We therefore examined the effectiveness and cost-effectiveness of the Adherence Improving self-Management Strategy (AIMS) compared with treatment as usual. METHODS: We did a pragmatic, multicentre, open-label, randomised controlled trial in seven HIV clinics at academic and non-academic hospitals in the Netherlands...
March 2, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28261794/nicotinic-acetylcholine-receptors-at-the-single-channel-level
#14
REVIEW
Cecilia Bouzat, Steven M Sine
Over the past four decades, the patch clamp technique and nicotinic acetylcholine (nACh) receptors have established an enduring partnership. Like all good partnerships, each partner has proven significant in its own right, while their union has spurred innumerable advances in life science research. A member and prototype of the superfamily of pentameric ligand-gated ion channels, the nACh receptor is a chemo-electric transducer, binding nerve-released ACh and rapidly opening its channel to cation flow to elicit cellular excitation...
March 5, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28248424/image-scanning-microscopy-an-overview
#15
E N Ward, R Pal
For almost a century, the resolution of optical microscopy was thought to be limited by Abbé's law describing the diffraction limit of light. At the turn of the millennium, aided by new technologies and fluorophores, the field of optical microscopy finally surpassed the diffraction barrier: a milestone achievement that has been recognized by the 2014 Nobel Prize in Chemistry. Many super-resolution methods rely on the unique photophysical properties of the fluorophores to improve resolution, posing significant limitations on biological imaging, such as multicoloured staining, live-cell imaging and imaging thick specimens...
March 1, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28246758/-when-all-of-you-will-be-forgotten-the-name-israel-will-still-be-shining-james-israel-1848-1926-a-career-in-the-german-empire-and-his-nomination-for-the-nobel-prize
#16
Friedrich H Moll, Thorsten Halling, Nils Hansson, Heiner Fangerau
In 1902, the Berlin Jewish urologist James Israel was nominated for the Nobel Prize in physiology or medicine. Taking scholar, social, and political aspects into consideration, this biographical essay traces how James Israel gained a sound scientific reputation especially in kidney surgery within Imperial Germany and its antisemitic attitude and how he promoted urology to become a specialty in its own right.
February 28, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28246359/remembering-emil-von-behring-from-tetanus-treatment-to-antibody-cooperation-with-phagocytes
#17
EDITORIAL
Stefan H E Kaufmann
A century ago, Emil von Behring passed away. He was the first to be honored by the Nobel Prize for Medicine in 1901 for the successful therapy of diphtheria and tetanus, which he had developed from the bench to the bed. He also contributed to the foundation of immunology, since his therapy was based on passive immunization with specific antisera. Being an ambitious character, he did not shy away from friction with his colleagues Paul Ehrlich and Elias Metchnikoff and his mentor, Robert Koch. Behring was not only an excellent translational researcher but also a successful entrepreneur and early proponent of public-private partnerships...
February 28, 2017: MBio
https://www.readbyqxmd.com/read/28208737/special-issue-on-ruthenium-complexes
#18
EDITORIAL
Ileana Dragutan, Valerian Dragutan, Albert Demonceau
The organic chemistry of ruthenium has been one of the most vigorously growing research areas over the past decades. Considerable effort has been extended towards the design and application of a broad series of ruthenium complexes, which culminated with the development by Ryoji Noyori (2001 Nobel Prize for Chemistry) of chiral ruthenium catalysts for stereoselective hydrogenation reactions [1], and the discovery by Robert H. Grubbs (2005 Nobel Prize for Chemistry) of well-defined ruthenium- benzylidene catalysts for olefin metathesis [2] [...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28207255/supramolecular-complexation-of-carbon-nanostructures-by-crown-ethers
#19
Luis Moreira, Beatriz M Illescas, Nazario Martín
Since their discovery, crown ethers as well as the most recent carbon nanostructures, namely fullerenes, carbon nanotubes, and graphene, have received a lot of attention from the chemical community. Merging these singular chemical structures by noncovalent forces has provided a large number of unprecedented supramolecular assemblies with new geometric and electronic properties whose more representative examples are presented in this Synopsis organized according to the different nature of the carbon nanostructures...
February 28, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28202601/cell-scientist-to-watch-arun-shukla
#20
(no author information available yet)
Arun Shukla received his master's degree in Biotechnology from the Jawaharlal Nehru University in New Delhi, and joined the lab of Nobel laureate Hartmut Michel at the Max Planck Institute of Biophysics in Frankfurt, Germany, for his PhD. He then moved to the United States for his postdoctoral work with Robert Lefkowitz at Duke University (Durham, NC) in a very close collaboration with Brian Kobilka (Stanford University, CA). Arun became an Assistant Professor in the Department of Medicine at Duke University in 2011, before returning to India in April 2014 as an Assistant Professor at the Indian Institute of Technology (IIT) in Kanpur as a Wellcome Trust DBT India Alliance Intermediate Fellow...
February 15, 2017: Journal of Cell Science
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