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https://www.readbyqxmd.com/read/28938456/growth-hormone-improves-cardiopulmonary-capacity-and-body-composition-in-children-with-growth-hormone-deficiency
#1
Donatella Capalbo, Flavia Barbieri, Nicola Improda, Francesco Giallauria, Elisa Di Pietro, Antonio Rapacciuolo, Raffaella Di Mase, Carlo Vigorito, Mariacarolina Salerno
Context: Growth hormone deficiency (GHD) in children may be associated with early cardiovascular risk factors and alterations in left ventricular (LV) structure and function; however, data on cardiopulmonary functional capacity are lacking. Objectives: Aim of the study was to evaluate the effect of GHD and GH therapy on cardiopulmonary functional capacity, left and right cardiac structure and function, and body composition in children and adolescents. Design: Prospective, case-control study...
August 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938308/sensor-based-physiologic-control-strategy-for-biventricular-support-with-rotary-blood-pumps
#2
Yu Wang, Steven C Koenig, Zhongjun Wu, Mark S Slaughter, Guruprasad A Giridharan
Rotary biventricular assist devices (BiVAD) are becoming a clinically accepted treatment option for end-stage biventricular failure. To improve BiVAD efficacy and safety, we propose a control algorithm to achieve the clinical objectives of maintaining left-right-sided balance, restoring physiologic flows, and preventing ventricular suction. The control algorithm consists of two proportional-integral (PI) controllers for left and right ventricular assist devices (LVAD and RVAD) to maintain differential pump pressure across LVAD (ΔPL) and RVAD (ΔPR) to provide left-right balance and physiologic flow...
September 21, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28937582/design-of-the-exercise-mri-evaluation-of-hiv-pulmonary-arterial-hypertension-longitudinal-determinants-exhalted-trial
#3
Mohamad Amer Alaiti, Aditya Goud, Gautam Ramani, Sashwatee Bagchi, Sadeer Al-Kindi, Steven Sawicki, Christopher Longenecker, Trevor Jenkins, David Pauza, Myung Park, Grace McComsey, Orlando Simonetti, Brian Hoit, Sanjay Rajagopalan
BACKGROUND: Pulmonary arterial hypertension (PAH) is a potentially serious cause of dyspnea and exercise limitation in patients with HIV infection. In this trial, we propose using exercise MRI in conjunction with cardiopulmonary testing to delineate PAH from other causes of cardiovascular dysfunction, identify individuals with exercise-induced PAH who are at high risk of developing resting PAH, and provide longitudinal estimates of progression of PAH and right ventricular function. METHODS: In this prospective observational study, HIV patients with dyspnea and exercise limitation in the absence of identifiable causes and those who meet the inclusion criteria will be enrolled based on resting pulmonary artery pressure (≤ or >40 mmHg) on a screening echocardiogram and exercise limitation on the Modified Medical Research Council dyspnea scale...
September 20, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28937256/evaluation-of-left-and-right-ventricular-systolic-and-diastolic-electromechanical-synchrony-in-older-people-a-population-based-observational-study
#4
R Laszlo, H Konz, K Kunz, D Dallmeier, J Klenk, M Denkinger, W Koenig, D Rothenbacher, J M Steinacker
It is unknown whether physiological ageing also goes along with electromechanical asynchrony of contraction. Aim of the study was to evaluate synchrony of contraction in older people with ("non-healthy") or without ("healthy") evidence for structural cardiac disease. In 547 persons (age 76.7+/-5.5 years, 306 male, 241 female) recruited from a population-based cohort of the ActiFE-Um study including a random sample of people >/= 65 years old living in the region of Ulm, Germany, various PW- and TDI-Doppler based markers for asynchrony were obtained by echocardiography...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28937040/surgical-outcomes-of-anomalous-origin-of-the-left-coronary-artery-from-the-pulmonary-artery-in-children-an-echocardiography-follow-up
#5
Yan Gao, Jing Zhang, Guo-Ying Huang, Xue-Cun Liang, Bing Jia, Xiao-Jing Ma
BACKGROUND: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare but potentially life-threatening congenital heart defect. A retrospective analysis was carried out to elucidate the surgical outcomes of ALCAPA in infants and children using follow-up echocardiography. METHODS: From September 2008 to March 2017, 26 children diagnosed with ALCAPA underwent left coronary re-implantation. All surviving patients received echocardiography during follow-up...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28937038/factors-related-to-ventricular-size-and-valvular-regurgitation-in-healthy-tibetans-in-lhasa
#6
Ying Yang, Yun-Dai Chen, Bin Feng, Zha-Xi-Duo Ji, Wei Mao, Guang Zhi
BACKGROUND: Lhasa is the main residence of Tibetans and one of the highest cities in the world. Its unique geography and ethnic population provide the chance to investigate the interactions among high altitude, ethnicity, and cardiac adaptation. Meanwhile, echocardiographic data about healthy Tibetans on a large scale are not available. This study aimed to analyze physiological factors related to ventricular size and valvular function in healthy Tibetans in Lhasa. METHODS: A representative sample of residents in Tibet was recruited using a multistage cluster random sampling method...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936441/correlation-between-electrocardiographic-changes-and-coronary-findings-in-patients-with-acute-myocardial-infarction-and-single-vessel-disease
#7
Abdallah Sanaani, Srikanth Yandrapalli, George Jolly, Rajiv Paudel, Howard A Cooper, Wilbert S Aronow
BACKGROUND: Correlation of ST-segment elevation on the 12-lead electrocardiogram (ECG) with the expected affected coronary territory is established in patients with ST-elevation myocardial infarction (STEMI). In patients with non-ST-elevation myocardial infarction (NSTEMI), correlation of ischemic ECG abnormalities with the affected coronary territory has not been well-established. We sought to investigate the correlation of electrocardiographic abnormalities with the location of 1-vessel obstructive coronary artery disease (CAD) in patients with both STEMI and NSTEMI...
September 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28934691/the-role-of-ppar-alpha-in-perfluorooctanoic-acid-induced-developmental-cardiotoxicity-and-l-carnitine-mediated-protection-results-of-in-ovo-gene-silencing
#8
Meng Zhao, Qixiao Jiang, Min Geng, Li Zhu, Yunqiu Xia, Aashish Khanal, Chunbo Wang
Perfluorooctanoic acid (PFOA) is a persistent organic pollutant. This study established an in ovo peroxisome proliferator-activated receptor alpha (PPAR alpha) silencing model in chicken embryo heart, and investigated the role of PPAR alpha in PFOA induced developmental cardiotoxicity. The in ovo silencing was achieved by introducing lentivirus expressing PPAR alpha siRNA into ED2 chicken embryo via microinjection (0.05ul/g egg weight). Transfection efficacy was confirmed by fluorescent microscopy and western blotting...
September 14, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28933244/ventricular-fibrillation-and-myocardial-depression-following-pulmonary-valve-replacement-in-tetralogy-of-fallot-with-an-intramural-coronary-artery-and-coronary-artery-compression-by-chest-tube
#9
Mubbasheer Ahmed, Nathan E Thompson, Susan R Foerster, Michele A Frommelt, Michael E Mitchell, John P Scott
We describe the case of a 10-year-old male with a history of repaired Tetralogy of Fallot and known intramural right coronary artery (RCA) who presented for bioprosthetic pulmonary valve replacement. The operation was complicated by postoperative ventricular fibrillation arrest. Selective coronary angiography revealed external compression of the mid-RCA by a mediastinal chest tube that improved immediately upon removal of the tube. Ultimately, the patient required additional unroofing of the intramural coronary for full recovery...
January 1, 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28932586/single-lung-retrieval-from-a-donor-supported-by-a-left-ventricular-assist-device
#10
Keitaro Matsumoto, Naoya Yamasaki, Tomoshi Tsuchiya, Takuro Miyazaki, Ryotaro Kamohara, Go Hatachi, Kazuyoshi Tanigawa, Kiyoyuki Eishi, Takeshi Nagayasu
The number of patients who need cardiac support with a left ventricular assist device (LVAD) has increased over the last decade. However, the number of reports of organ retrieval from donors with an LVAD is still small. Successful lung retrieval for single lung transplantation was performed from a donor on LVAD support. This required special care not to injure the heart, great vessels, and the device, particularly the outflow conduit, because of significant conglutination around the device. A right single lung transplantation was performed successfully, with no postoperative complications...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28929619/assessment-of-subclinical-right-ventricular-systolic-dysfunction-in-coal-miners-using-myocardial-isovolumic-acceleration
#11
Ozge Ozcan Abacıoglu, Mehmet Kaplan, Serkan Abacıoglu, Ala Quisi
OBJECTIVE: Several studies have been conducted regarding the effects of coal mining on the respiratory system. However, there is a lack of data concerning potential effects of coal mining on the cardiovascular system. In this study, we aimed to evaluate the potential subclinical right and left ventricular dysfunction in coal miners. METHODS: This single-center, prospective study included a total of 102 patients. Patient and control groups consisted of 54 coal miners and 48 healthy men, respectively...
September 2017: Echocardiography
https://www.readbyqxmd.com/read/28929528/a-quality-control-exercise-in-the-echo-laboratory-reduction-in-inter-observer-variability-in-the-interpretation-of-pulmonary-hypertension
#12
Daniel M Patton, Atoosa Enzevaie, Andrew Day, Anthony Sanfilippo, Amer M Johri
BACKGROUND: Right ventricular systolic pressure (RVSP) estimated by echocardiography is critical for the initial screening and follow-up of pulmonary hypertension (PH). Inter-observer variability (IOV) in RVSP can impact clinical decision making. This study assessed whether a simple guideline-based teaching intervention could reduce the IOV in RVSP interpretation. METHODS AND RESULTS: Eleven participants in a high-volume tertiary level echocardiography laboratory underwent an assessment of the baseline IOV in the assessment of RVSP for a series of transthoracic echocardiograms (TTE), depicting various degrees of PH among 8 cases each before and after a teaching intervention...
September 19, 2017: Echocardiography
https://www.readbyqxmd.com/read/28929112/imaging-diagnosis-of-right-ventricle-involvement-in-chagas-cardiomyopathy
#13
REVIEW
Minna M D Romano, Henrique T Moreira, André Schmidt, Benedito Carlos Maciel, José Antônio Marin-Neto
Right ventricle (RV) is considered a neglected chamber in cardiology and knowledge about its role in cardiac function was mostly focused on ventricular interdependence. However, progress on the understanding of myocardium diseases primarily involving the RV led to a better comprehension of its role in health and disease. In Chagas disease (CD), there is direct evidence from both basic and clinical research of profound structural RV abnormalities. However, clinical detection of these abnormalities is hindered by technical limitations of imaging diagnostic tools...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28928990/detection-of-a-left-superior-vena-cava-during-a-pacemaker-implantation-in-cotonou
#14
A Sonou, M Hounkponou, L Codjo, P M Adjagba, C Houehanou, H Dohou, S Assani, Y Tchabi, M Houenassi
Persistent left superior vena cava (LSVC) is a rare congenital anomaly. Its prevalence in the general population is 0.1 to 0.5%. LSVC is 5 times rarer when accompanied by an absence of the right superior vena cava (RSVC). We present the case of a 54-year-old man who carries a persistent LSVC without RSVC. Clinically, this patient presented a regular bradycardia at 40 per minute associated with a heart failure syndrome. The electrocardiogram diagnosed a complete atrioventricular block and transthoracic echocardiography showed dilated left heart cavities and a left ventricular ejection fraction of 50%...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28928978/implantation-of-the-micra-leadless-pacemaker-in-a-patient-with-a-low-body-mass-index-of-16
#15
Gary Tse, Tong Liu, Guangping Li, Wing Tak Wong, Gary Chin Pang Chan, Yat Sun Chan, Bryan Yan
A 71-year-old female patient has a history of complete heart block and recurrent pacemaker site infection requiring multiple pacemaker explanations. A leadless pacemaker using passive fixation was inserted into the right ventricular apex via transvenous approach without complications. This case illustrates the feasibility of implanting a leadless pacemaker system in a small-sized adult with a low body mass index of 16 (weight: 33.7 kg, height: 145 cm) which may have potential application in elderly Asian subjects...
September 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28928615/stenting-of-right-ventricular-outflow-tract-in-tetralogy-of-fallot-with-subarterial-ventricular-septal-defect-a-word-of-caution
#16
Jonathan Lee, Sivakumar Sivalingam, Mazeni Alwi
We report a case of Tetralogy of Fallot with severe cyanosis who underwent a successful right ventricular outflow tract stenting. Follow-up echocardiography revealed moderate aortic regurgitation due to the impingement of the stent on the aortic valve. The patient underwent successful surgical correction at which time the stent was removed completely with a resolution of the aortic regurgitation.
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28928607/speckle-tracking-evaluation-of-right-ventricular-functions-in-children-with-sickle-cell-disease
#17
Osama Abd Rab Elrasol Tolba, Mohamed Ramadan El-Shanshory, Mohamed Abd Elaziz El-Gamasy, Walid Ahmed El-Shehaby
BACKGROUND: Cardiac dysfunction is a risk factor for death in patients with sickle cell disease (SCD). AIM OF THE WORK: Aim of the work is to evaluate the right ventricular systolic and diastolic functions by tissue Doppler and speckling tracking imaging in children with SCD. SUBJECTS AND METHODS: Thirty children with SCD and thirty controls were subjected to clinical, laboratory evaluations, and echocardiographic study using GE Vivid 7 (GE Medical System, Horten, Norway with a 3...
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28928601/early-right-ventricular-apical-pacing-induced-gene-expression-alterations-are-associated-with-deterioration-of-left-ventricular-systolic-function
#18
Haiyan Xu, Xiongwei Xie, Jiangjin Li, Yuanyuan Zhang, Changsong Xu, Jing Yang
The chronic high-dose right ventricular apical (RVA) pacing may have deleterious effects on left ventricular (LV) systolic function. We hypothesized that the expression changes of genes regulating cardiomyocyte energy metabolism and contractility were associated with deterioration of LV function in patients who underwent chronic RVA pacing. Sixty patients with complete atrioventricular block and preserved ejection fraction (EF) who underwent pacemaker implantation were randomly assigned to either RVA pacing (n = 30) group or right ventricular outflow tract (RVOT) pacing (n = 30) group...
2017: Disease Markers
https://www.readbyqxmd.com/read/28927316/cardiovascular-magnetic-resonance-detects-silent-heart-disease-missed-by-echocardiography-in-systemic-lupus-erythematosus
#19
S Mavrogeni, L Koutsogeorgopoulou, G Markousis-Mavrogenis, A Bounas, M Tektonidou, S-N C Lliossis, D Daoussis, S Plastiras, G Karabela, E Stavropoulos, G Katsifis, V Vartela, G Kolovou
Background Accurate diagnosis of cardiovascular involvement in systemic lupus erythematosus (SLE) remains challenging, due to limitations of echocardiography. We hypothesized that cardiovascular magnetic resonance can detect cardiac lesions missed by echocardiography in SLE patients with atypical symptoms. Aim To use cardiovascular magnetic resonance in SLE patients with atypical symptoms and investigate the possibility of silent heart disease, missed by echocardiography. Patients/methods From 2005 to 2015, 80 SLE patients with atypical cardiac symptoms/signs (fatigue, mild shortness of breath, early repolarization and sinus tachycardia) aged 37 ± 6 years (72 women/8 men), with normal echocardiography, were evaluated using a 1...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28926602/autoimmune-disease-mouse-model-exhibits-pulmonary-arterial-hypertension
#20
Koichi Sugimoto, Kazuhiko Nakazato, Akihiko Sato, Satoshi Suzuki, Akiomi Yoshihisa, Takeshi Machida, Shu-Ichi Saitoh, Hideharu Sekine, Yasuchika Takeishi
BACKGROUND: Pulmonary arterial hypertension is often associated with connective tissue disease. Although there are some animal models of pulmonary hypertension, an autoimmune disease-based model has not yet been reported. MRL/lpr mice, which have hypergammaglobulinemia, produce various autoimmune antibodies, and develop vasculitis and nephritis spontaneously. However, little is known about pulmonary circulation in these mice. In the present study, we examined the pulmonary arterial pressure in MRL/lpr mice...
2017: PloS One
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