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https://www.readbyqxmd.com/read/29331842/predicting-1-year-disability-and-mortality-of-injured-older-adults
#1
Alvin D Jeffery, Mary S Dietrich, Cathy A Maxwell
PURPOSE: The growing incidence of elderly patients injured from falls, combined with a growing understanding of the contribution of cognition and frailty to mortality, prompted this work. Our objective was to develop a clinical risk prediction model for prognosticating disability and mortality among injured older adults 1 year after hospitalization. METHODS: Secondary analysis of prospective longitudinal data from an urban Level 1 trauma center. A proportional odds regression model was used to model mortality and functional status as ordinal outcomes...
January 6, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29331082/mechanistic-target-of-rapamycin-complex-1-and-2-in-human-temporal-lobe-epilepsy
#2
Delia M Talos, Leah M Jacobs, Sarah Gourmaud, Carlos A Coto, Hongyu Sun, Kuei-Cheng Lim, Timothy H Lucas, Kathryn A Davis, Maria Martinez-Lage, Frances E Jensen
OBJECTIVE: Temporal lobe epilepsy (TLE) is a chronic epilepsy syndrome defined by seizures and progressive neurological disabilities, including cognitive impairments, anxiety and depression. Here, human TLE specimens were investigated focusing on the mechanistic target of rapamycin (mTOR) Complex 1 (mTORC1) and Complex 2 (mTORC2) activities in the brain, as both pathways may represent unique targets for treatment. METHODS: Surgically resected hippocampal and temporal lobe samples from therapy-resistant TLE patients were analyzed by Western blotting to quantify the expression of established mTORC1 and mTORC2 activity markers and upstream or downstream signaling pathways involving the two complexes...
January 13, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29330230/reducing-sedentary-behaviour-to-decrease-chronic-low-back-pain-the-stand-back-randomised-trial
#3
Bethany Barone Gibbs, Andrea L Hergenroeder, Sophy J Perdomo, Robert J Kowalsky, Anthony Delitto, John M Jakicic
OBJECTIVE: The Stand Back study evaluated the feasibility and effects of a multicomponent intervention targeting reduced prolonged sitting and pain self-management in desk workers with chronic low back pain (LBP). METHODS: This randomised controlled trial recruited 27 individuals with chronic LBP, Oswestry Disability Index (ODI) >10% and desk jobs (sitting ≥20 hours/week). Participants were randomised within strata of ODI (>10%-<20%, ≥20%) to receive bimonthly behavioural counselling (in-person and telephone), a sit-stand desk attachment, a wrist-worn activity-prompting device and cognitive behavioural therapy for LBP self-management or control...
January 12, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29327593/the-impact-of-age-and-gender-on-the-icf-based-assessment-of-chronic-low-back-pain
#4
Elisabeth Fehrmann, Simone Kotulla, Linda Fischer, Thomas Kienbacher, Kerstin Tuechler, Patrick Mair, Gerold Ebenbichler, Birgit Paul
PURPOSE: To evaluate the impact of age and gender on the international classification of functioning, disability and health (ICF)-based assessment for chronic low back pain. METHODS: Two hundred forty-four chronic low back pain patients (52% female) with a mean age of 49 years (SD =17.64) were interviewed with the comprehensive ICF core set for activities and participation, and environmental factors. After conducting explorative factor analysis, the impact of age and gender on the different factors was analyzed using analyzes of variances...
January 12, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29327378/comparing-impact-on-the-family-and-insurance-coverage-in-children-with-cerebral-palsy-and-children-with-another-special-healthcare-need
#5
B Schaible, G Colquitt, M C Caciula, A Carnes, L Li, N Moreau
BACKGROUND: Families and caregivers of children with special healthcare needs (CSHCN) often experience financial difficulties, have unmet physical and mental health needs, and are at increased risk of marital problems due to the stress caused by carrying for their child. Within the larger population of CHSCN, young people with cerebral palsy (CP) have more unmet needs due to the complexity and potential severity of the disability. The purpose of this study was to identify factors associated with differences in insurance coverage and impact on the family of children with CP and other CHSCN...
January 12, 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29326900/development-of-strategies-for-changing-in-physical-activity-behaviors-on-older-adults-with-disabilities
#6
Kyo-Man Koo, Chae-Hee Park, Chun-Jong Kim
The purpose of this study was to develop strategies for promoting physical activity for the disabled older adults who were in the transtheoretical model of precontemplation, contemplation, and preparation stages about participating physical activities for promoting healthy life-styles. In order to achieve this goal, we developed a preliminary strategy for promoting physical activity for the elderly with disabilities based on the data gathered through the ground-work studies and the results of the research on the changes of the exercise behavior directly investigated from the elderly with disabilities...
December 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29325472/latent-psychological-distress-existing-behind-a-set-of-assessment-measures-is-comparable-to-or-more-important-than-symptoms-or-disability-in-the-association-with-quality-of-life-and-working-status-of-patients-with-rheumatoid-arthritis
#7
Akie Hirata, Tomoya Miyamura, Yasuo Suenaga, Masao Katayama, Eiichi Suematsu, Shigeto Tohma
OBJECTIVES: To identify the determinant of patients' perspectives of quality of life (QOL) and working status out of analysis-derived components underlying a set of assessment measures of the status of patients with rheumatoid arthritis (RA). METHODS: From the NinJa database in Japan (2012-2014), 1455 RA patients with DAS28 >3.2 were recruited. Components explaining RA status were derived from principal component analysis of 15 assessment measures. Multivariate regression was used to examine the relative contribution of each identified component to the EuroQOL-5 Dimension Questionnaire score and working status...
January 12, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29323524/work-disability-in-soldiers-with-posttraumatic-stress-disorder-posttraumatic-embitterment-disorder-and-not-event-related-common-mental-disorders
#8
Beate Muschalla, Heinrich Rau, Gerd Dieter Willmund, Christine Knaevelsrud
OBJECTIVE: Posttraumatic mental disorders may occur with different affect qualities. Best known is posttraumatic stress disorder (PTSD), a conditioned anxiety reaction with intrusions. Another event-related mental disorder is posttraumatic embitterment (PTED), characterized by affect of embitterment and thoughts of revenge, occurring after an event deeply hurting basic beliefs. Knowing about associated disability is important for treatment and sociomedical decisions. This is the first study to explore work-disability in patients with PTSD, PTED, and not-event-related common mental disorder (CMD)...
January 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29322749/time-reversed-ultrasonically-encoded-optical-focusing-through-highly-scattering-ex-vivo-human-cataractous-lenses
#9
Yan Liu, Yuecheng Shen, Haowen Ruan, Frank L Brodie, Terence T W Wong, Changhuei Yang, Lihong V Wang
Normal development of the visual system in infants relies on clear images being projected onto the retina, which can be disrupted by lens opacity caused by congenital cataract. This disruption, if uncorrected in early life, results in amblyopia (permanently decreased vision even after removal of the cataract). Doctors are able to prevent amblyopia by removing the cataract during the first several weeks of life, but this surgery risks a host of complications, which can be equally visually disabling. Here, we investigated the feasibility of focusing light noninvasively through highly scattering cataractous lenses to stimulate the retina, thereby preventing amblyopia...
January 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29319352/dual-antegrade-intramedullary-headless-screw-fixation-for-treatment-of-unstable-proximal-phalanx-fractures
#10
Michael P Gaspar, Shiv D Gandhi, Randall W Culp, Patrick M Kane
BACKGROUND: Although intramedullary headless screw (IMHS) fixation is a promising minimally invasive surgical treatment option for unstable proximal phalanx fractures, a single IMHS may provide inadequate fixation for certain fracture patterns. The purpose of this study was to evaluate the short-term clinical outcomes in a pilot series of patients with proximal phalanx fractures treated with dual antegrade IMHS fixation. METHODS: We performed a retrospective chart review of proximal phalanx fractures treated with dual antegrade IMHS fixation with a minimum 1 year of follow-up...
January 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29319274/evaluating-a-co-facilitation-approach-to-service-user-and-carer-involvement-in-undergraduate-nurse-education
#11
Anne Felton, Joan Cook, Roni Anthony
Partnership working with service users and carers is an integral aspect of healthcare practice and education. Increasingly complex healthcare environments, alongside changes in higher education, have led to the development of innovative learning strategies, resulting in opportunities for service users to participate in nurse education. This article describes the planning, implementation and evaluation of a co-facilitation approach to learning, in which service users and carers worked alongside lecturers to facilitate small seminar group activities with first-year undergraduate nursing students...
January 10, 2018: Nursing Standard
https://www.readbyqxmd.com/read/29318030/environmental-temperature-and-exercise-modality-independently-impact-central-and-muscle-fatigue-among-people-with-multiple-sclerosis
#12
Geetika Grover, Michelle Ploughman, Devin T Philpott, Liam P Kelly, Augustine J Devasahayam, Katie Wadden, Kevin E Power, Duane C Button
Background: Heat sensitivity and fatigue limit the ability of multiple sclerosis patients to participate in exercise. Objective: The purpose of this study was to determine the optimal aerobic exercise parameters (environmental temperature and exercise modality) to limit exercise-induced central and muscle fatigue among people with multiple sclerosis. Methods: Fourteen people with multiple sclerosis with varying levels of disability completed four randomized exercise sessions at 65% of the maximal volume of oxygen: body-weight supported treadmill cool (16°C), body-weight supported treadmill room (21°C), total-body recumbent stepper cool and total-body recumbent stepper room...
October 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29317957/prevalence-of-migraine-headache-in-taif-city-saudi-arabia
#13
Ziyad Atiah Almalki, Mohammed Abdullah Ghramah Alzhrani, Asmaa Turki Altowairqi, Yara Abdulaziz Aljawi, Sarah Abdulaziz Fallatah, Luai Mohammed Assaedi, Mohammed Abdulaziz Aljawi, Sadeem Adnan Alqusair
Background: Migraine is a public health problem and it is the third most common cause of disability among individuals below the age of 50. In spite of the multiplicity of the studies concerned with exploring the disease epidemiology and nature worldwide, data from Saudi Arabia are lacking. The aim of this study was to study the prevalence of migraine in Taif city, Saudi Arabia. Methods: This was a cross-sectional study conducted on 354 individuals in Taif city. Data were collected via a self-administered questionnaire including demographic variables, clinical variables, and therapeutic variables...
February 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29317298/social-participation-and-psychosocial-outcomes-of-young-adults-with-chronic-physical-conditions-comparing-recipients-and-non-recipients-of-disability-benefits
#14
Marjolijn I Bal, Jane N T Sattoe, Harald S Miedema, AnneLoes van Staa
BACKGROUND: Little is known about any differences between young people with chronic physical conditions who do and do not apply for disability benefits in young adulthood for providing insights for future policy and rehabilitation care. OBJECTIVE: We aimed to identify predictors during adolescence of receiving disability benefits in young adulthood and to compare recipients and non-recipients of benefits in social participation and psychosocial outcomes in young adulthood...
January 6, 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29316232/problem-solving-skills-parent-adolescent-communication-dyadic-functioning-and-distress-among-adolescents-with-cancer
#15
Adrienne Viola, Alison Taggi-Pinto, Olle Jane Z Sahler, Melissa A Alderfer, Katie A Devine
Some adolescents with cancer report distress and unmet needs. Guided by the disability-stress-coping model, we evaluated associations among problem-solving skills, parent-adolescent cancer-related communication, parent-adolescent dyadic functioning, and distress in adolescents with cancer. Thirty-nine adolescent-parent dyads completed measures of these constructs. Adolescents were 14-20 years old on treatment or within 1 year of completing treatment. Better problem-solving skills were correlated with lower adolescent distress (r = -0...
January 9, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29315926/occupational-status-among-adult-survivors-following-allogeneic-stem-cell-transplantation-in-childhood
#16
Jeanette Winterling, Eva Johansson, Lena Wettergren, Per Ljungman, Kristina Alexanderson
This study examined occupational status and factors associated with sick leave and disability pension among adult long-term survivors previously treated with allogeneic stem cell transplantation (allo-SCT) during childhood. Moreover, occupational status was compared to that of a reference group. Data were collected with questionnaires and from medical records. The SCT group included 59 adults (18-45 years old: response rate 63%) treated with allo-SCT in childhood with a median of 17 (range 3-28) years earlier...
January 8, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29315428/cervical-radiculopathy-effectiveness-of-adding-traction-to-physical-therapy-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#17
Paolo Pillastrini, Antonio Romeo, Carla Vanti, Valerio Boldrini, Martina Ruggeri, Andrew Guccione, Lucia Bertozzi
Background: Cervical radiculopathy (CR) is a common cervical spine disorder. Cervical traction (CT) is a frequently recommended treatment for patients with CR. Purpose: The purpose of this study was to conduct a review and meta-analysis of randomized controlled trials (RCTs) on the effect of CT combined with other physical therapy procedures versus physical therapy procedures alone on pain and disability. Data Sources: Data were obtained from COCHRANE Controlled Trials Register, PubMed, CINAHL, Scopus, ISI Web of Science, and PEDro, from their inception to July 2016...
January 5, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29314645/tofacitinib-with-conventional-synthetic-disease-modifying-antirheumatic-drugs-in-chinese-patients-with-rheumatoid-arthritis-patient-reported-outcomes-from-a-phase-3-randomized-controlled-trial
#18
Zhanguo Li, Yuan An, Houheng Su, Xiangpei Li, Jianhua Xu, Yi Zheng, Guiye Li, Kenneth Kwok, Lisy Wang, Qizhe Wu
AIM: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We assess the effect of tofacitinib + conventional synthetic disease-modifying anti rheumatic drugs (csDMARDs) on patient-reported outcomes in Chinese patients with RA and inadequate response to DMARDs. METHODS: This analysis of data from the Phase 3 study ORAL Sync included Chinese patients randomized 4 : 4 : 1 : 1 to receive tofacitinib 5 mg twice daily, tofacitinib 10 mg twice daily, placebo→tofacitinib 5 mg twice daily, or placebo→tofacitinib 10 mg twice daily, with csDMARDs...
January 4, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29314463/prevalence-and-patterns-of-anti-epileptic-medication-prescribing-in-the-treatment-of-epilepsy-in-older-adults-with-intellectual-disabilities
#19
M O'Dwyer, J Peklar, N Mulryan, P McCallion, M McCarron, M C Henman
BACKGROUND: The prevalence of epilepsy is higher in people with intellectual disability (ID) and increases with the degree of ID. Although life expectancy for people with ID is increasing, people with ID coexisting with epilepsy have a higher mortality rate, particularly those who had recent seizures. There have been few observational studies of the prevalence and patterns of anti-epileptic prescribing among older people with ID and epilepsy. The aim of this study was to investigate prevalence and patterns of anti-epileptic prescribing in the treatment of epilepsy in a representative population of older people with ID and epilepsy...
January 5, 2018: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29310946/validation-of-lumbar-spine-loading-from-a-musculoskeletal-model-including-the-lower-limbs-and-lumbar-spine
#20
Jason A Actis, Jasmin D Honegger, Deanna H Gates, Anthony J Petrella, Luis A Nolasco, Anne K Silverman
Low back mechanics are important to quantify to study injury, pain and disability. As in vivo forces are difficult to measure directly, modeling approaches are commonly used to estimate these forces. Validation of model estimates is critical to gain confidence in modeling results across populations of interest, such as people with lower-limb amputation. Motion capture, ground reaction force and electromyographic data were collected from ten participants without an amputation (five male/five female) and five participants with a unilateral transtibial amputation (four male/one female) during trunk-pelvis range of motion trials in flexion/extension, lateral bending and axial rotation...
December 13, 2017: Journal of Biomechanics
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