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https://www.readbyqxmd.com/read/29774169/phase-2-study-of-everolimus-for-relapsed-or-refractory-classical-hodgkin-lymphoma
#1
Patrick B Johnston, Lauren C Pinter-Brown, Ghulam Warsi, Kristen White, Radhakrishnan Ramchandren
Background: The current standard of care for classical Hodgkin lymphoma (HL) is multiagent chemotherapy with or without radiation. In patients who relapse or fail to respond, additional high-dose chemotherapy with autologous hematopoietic stem cell transplantation (AHSCT) can improve progression-free survival (PFS). Novel therapies are required for patients refractory to chemotherapy and AHSCT. The mammalian target of rapamycin inhibitor everolimus has shown preliminary activity in preclinical models of HL and promising efficacy in patients with relapsed or refractory HL...
2018: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29771941/efficacy-of-ivermectin-mass-drug-administration-to-control-scabies-in-asylum-seekers-in-the-netherlands-a-retrospective-cohort-study-between-january-2014-march-2016
#2
Dorien T Beeres, Sofanne J Ravensbergen, Annelies Heidema, Darren Cornish, Machiel Vonk, Leonie D Wijnholds, Jessica J H Hendriks, Johanneke Kleinnijenhuis, Till F Omansen, Ymkje Stienstra
Scabies is a skin infestation with the mite Sarcoptes scabiei causing itch and rash and is a major risk factor for bacterial skin infections and severe complications. Here, we evaluated the treatment outcome of 2866 asylum seekers who received (preventive) scabies treatment before and during a scabies intervention programme (SIP) in the main reception centre in the Netherlands between January 2014 and March 2016. A SIP was introduced in the main national reception centre based on frequent observations of scabies and its complications amongst Eritrean and Ethiopian asylum seekers in the Netherlands...
May 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29765150/phase-i-studies-of-azd1208-a-proviral-integration-moloney-virus-kinase-inhibitor-in-solid-and-haematological-cancers
#3
Jorge Cortes, Kenji Tamura, Daniel J DeAngelo, Johann de Bono, David Lorente, Mark Minden, Geoffrey L Uy, Hagop Kantarjian, Lisa S Chen, Varsha Gandhi, Robert Godin, Karen Keating, Kristen McEachern, Karthick Vishwanathan, Janet Elizabeth Pease, Emma Dean
BACKGROUND: Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanced solid tumours. METHODS: Two dose-escalation studies were performed to evaluate the safety and tolerability, and to define the maximum tolerated dose (MTD), of AZD1208 in AML and solid tumours...
May 16, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29763476/drug-induced-linear-iga-bullous-dermatosis-in-a-patient-with-a-vancomycin-impregnated-cement-spacer
#4
Kelsie Riemenschneider, Daren A Diiorio, John A Zic, Matthew R Livingood, Jo-David Fine, Jennifer G Powers, Jeffrey P Zwerner, Eric Tkaczyk
Linear IgA bullous dermatosis (LABD) is an autoimmune blistering rash caused by IgA autoantibodies against the epidermal basement membrane zone. It commonly is drug induced, often in association with systemic vancomycin. We report a case of a previously healthy 77-year-old man who developed a diffuse macular rash and hemorrhagic bullae on the left leg 10 days after placement of a vancomycin-impregnated cement spacer (VICS) during a revision knee arthroplasty and initiation of postoperative treatment with intravenous (IV) vancomycin...
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29756718/-drug-reaction-with-eosinophilia-and-systemic-symptoms-due-to-carbamazepine-pediatric-case
#5
Rocío Del P Pereira-Ospina, Ana M Bejarano-Quintero, José M Suescún-Vargas, Javier Y Pinzón-Salamanca
Severe skin reactions include Stevens-Johnson Syndrome, toxic epidermal necrolysis and Drug reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome, which are uncommon in the pediatric population (incidence 1/1000- 10 000 children), but they have bad prognosis. Drug-sensitive Syndrome with eosinophilia and systemic symptoms consists in rash, hematological abnormalities, lymphadenopathy and organ involvement. We report the case of a 12-year-old male patient who developed this pathology after initiating anticonvulsant therapy with carbamazepine...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29756421/survey-of-cutaneous-adverse-reactions-to-targeted-cancer-therapies-value-of-dermatological-advice
#6
Giovanni Damiani, Ausilia Manganoni, Simone Cazzaniga, Luigi Naldi
BACKGROUND: Target-therapy offers a better efficacy for several cancers, with less toxic adverse effects, if compared with traditional chemotherapy. However cutaneous complications are increased in number and complexity. The severity of these reactions positively correlates with efficacy, and the management of these reactions is challenging. METHODS: This was a multicenter cross-sectional study on a consecutive series of adult patients with incident cutaneous reactions linked to targeted cancer therapies observed in five referral centers for cancer treatment in the province of Bergamo and Brescia in northern Italy...
May 11, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29756000/bullous-fixed-drug-eruption-following-ibuprofen-ingestion
#7
Seyed Amirhossein Fazeli, Morteza Abbasi, Hadi Jalali, Sonia Eskandari, Farzaneh Shamshirgaran, Zahra Dehghani, Reza Golabchifard, Shahram Ghiyasvand, Kaveh Ghannad
Fixed drug eruption (FDE) is a drug reaction involving skin and less commonly mucosal membranes. The common manifestation is localized well-demarcated patches or plaques appeared following receiving of a culprit drug. When re-exposure occurs, the rashes will appear at areas involved in previous episodes. Limited reports on bullous FDE due to ibuprofen have been documented before. Herein, we described an elderly man who experienced multifocal lesions in his oral mucosa, penis, and multiple sites of skin following ibuprofen ingestion confirmed as FDE by pathological studies...
January 2018: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29743410/safety-of-reversing-anticoagulation-by-protamine-following-elective-transfemoral-percutaneous-coronary-intervention-in-the-drug-eluting-stent-era
#8
Shingo Yamamoto, Kenichi Sakakura, Yousuke Taniguchi, Kei Yamamoto, Hiroshi Wada, Shin-Ichi Momomura, Hideo Fujita
Bleeding complications following percutaneous coronary interventions (PCI) have been closely associated with morbidity and mortality. Although radial arteries have been widely used in current PCI, including primary PCI, transfemoral PCI remains necessary for complex PCI. The purpose of this study was to compare the incidence of complications following elective transfemoral PCI between manual compression with and without protamine. We identified 249 consecutive patients who underwent elective transfemoral PCI from hospital records, and divided them into two groups: patients who used protamine for manual compression (the protamine group; n = 205) and patients who did not (the non-protamine group, n = 44)...
May 9, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29742194/widespread-skin-necrosis-secondary-to-gemcitabine-therapy
#9
Patrick M Zito, Adrianna M Gonzalez, Joshua D Fox, Megan Cronin, Nicholas Mackrides, Robert S Kirsner, Anna J Nichols
Gemcitabine, a pyrimidine nucleoside analogue, is an oncologic agent used in the treatment of cutaneous T-cell lymphoma (CTCL). Common dermatologic reactions associated with gemcitabine include alopecia, mild skin rash, and mucositis but skin necrosis is exceptional. Herein we present an unusual case of widespread skin necrosis mimicking toxic epidermal necrolysis in a 45-year-old woman receiving gemcitabine therapy for stage IIIA cutaneous T-cell lymphoma. This is the first reported case of a TEN-like reaction subsequent to gemcitabine treatment...
May 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29736694/pre-surgical-trial-of-the-akt-inhibitor-mk-2206-in-patients-with-operable-invasive-breast-cancer-a-new-york-cancer-consortium-trial
#10
K Kalinsky, J A Sparano, X Zhong, E Andreopoulou, B Taback, L Wiechmann, S M Feldman, P Ananthakrishnan, A Ahmad, S Cremers, A N Sireci, J R Cross, D K Marks, P Mundi, E Connolly, K D Crew, M A Maurer, H Hibshoosh, S Lee, D L Hershman
INTRODUCTION: The PI3K/AKT/mTOR pathway is an oncogenic driver in breast cancer (BC). In this multi-center, pre-surgical study, we evaluated the tissue effects of the AKT inhibitor MK-2206 in women with stage I-III BC. MATERIALS AND METHODS: Two doses of weekly oral MK2206 were administered at days - 9 and - 2 before surgery. The primary endpoint was reduction of pAktSer473 in breast tumor tissue from diagnostic biopsy to surgery. Secondary endpoints included changes in PI3K/AKT pathway tumor markers, tumor proliferation (ki-67), insulin growth factor pathway blood markers, pharmacokinetics (PK), genomics, and MK-2206 tolerability...
May 7, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29734047/efficacy-and-safety-of-single-agent-pan-human-epidermal-growth-factor-receptor-her-inhibitor-dacomitinib-in-locally-advanced-unresectable-or-metastatic-skin-squamous-cell-cancer
#11
S Cavalieri, F Perrone, R Miceli, P A Ascierto, L D Locati, C Bergamini, R Granata, S Alfieri, C Resteghini, D Galbiati, A Busico, N Paielli, R Patuzzo, A Maurichi, G Gallino, R Ruggeri, L Mariani, M Palla, L Licitra, P Bossi
BACKGROUND: In recurrent or metastatic (R/M) skin squamous cell cancer (sSCC) not amenable to radiotherapy (RT) or surgery, chemotherapy (CT) has a palliative intent and limited clinical responses. The role of oral pan-HER inhibitor dacomitinib in this setting was investigated within a clinical trial. METHODS: Patients with diagnosis of R/M sSCC were treated. Dacomitinib was started at a dose of 30 mg daily (QD) for 15 d, followed by 45 mg QD. Primary end-point was response rate (RR)...
May 4, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29723945/-are-natural-analgesic-products-safe-in-patients-with-allergy-to-non-steroidal-anti-inflammatory-drugs
#12
Iván Chérrez-Ojeda, Juan Carlos Calderón, Erick Calero, César Terán, Annia Chérrez
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAID)-induced hypersensitivity reactions can be clinically apparent with asthma, rhinosinusitis, anaphylaxis or rash. Although natural anti-inflammatory products can have similar components, they are not subjected to rigorous quality control standards. CASE REPORT: The case is presented of a 22-year-old female with NSAID allergy who attended with facial and laryngeal angioedema associated with pruritus in eyelids and pharynx...
January 2018: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29721056/the-efficacy-and-toxicity-of-gefitinib-in-treating-non-small-cell-lung-cancer-a-meta-analysis-of-19-randomized-clinical-trials
#13
Hongmei Wo, Jing He, Yang Zhao, Hao Yu, Feng Chen, Honggang Yi
Background: This meta-analysis evaluated the efficacy and toxicity of gefitinib with other commonly used drugs in different treatment settings and epidermal growth factor receptor (EGFR) mutation status. Methods: Nineteen randomize clinical trials (RCTs) of 6,554 patients with NSCLC were pooled in this meta-analysis by random-effects or fixed-effects model, whichever is proper. Results: In first-line therapy, gefitinib showed higher odds than chemotherapy (OR = 2.19, 95% CI: 1.20-4.01), but less than other targeted therapies (OR = 0...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29720364/monitoring-interest-in-herpes-zoster-vaccination-analysis-of-google-search-data
#14
Elyse J Berlinberg, Michael S Deiner, Travis C Porco, Nisha R Acharya
BACKGROUND: A new recombinant subunit vaccine for herpes zoster (HZ or shingles) was approved by the United States Food and Drug Administration on October 20, 2017 and is expected to replace the previous live attenuated vaccine. There have been low coverage rates with the live attenuated vaccine (Zostavax), ranging from 12-32% of eligible patients receiving the HZ vaccine. OBJECTIVE: This study aimed to provide insight into trends and potential reasons for interest in HZ vaccination...
May 2, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29710019/-parkinson-s-disease-associated-with-sapho-syndrome-a-case-report
#15
Takashi Ando, Amane Araki, Shinichi Terao, Masahisa Katsuno
A 77-year-old woman with Parkinson's disease presented with left chest pain. Physical examination revealed tenderness at her second left sternocostal joint. There was no skin rash. Chest CT revealed hyperostosis of the sternocostal joint, and cervical MRI showed vertebral osteosclerosis and osteolysis. 99mTc-MDP bone scintigraphy showed an increased activity in the sternocostal joint and vertebral column. The patient was diagnosed with SAHPO syndrome according to the diagnostic criteria. Her chest pain was relieved after oral administration of nonsteroidal anti-inflammatory drugs...
April 28, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29703869/a-10-years-retrospective-study-on-severe-cutaneous-adverse-reactions-scars-in-a-tertiary-hospital-in-penang-malaysia
#16
C H Loo, W C Tan, Y H Khor, L C Chan
INTRODUCTION: Severe cutaneous adverse drug reactions (SCARs) are not uncommon and potentially lifethreatening. Our objective is to study the patient characteristics, the pattern of implicated drugs and treatment outcome among patients with SCARs. METHODS: A 10-year retrospective analysis of SCARs cases in Penang General Hospital was carried out from January 2006 to December 2015. Data collection is based on the Malaysian Adverse Drug Reactions Advisory Committee registry and dermatology clinic records...
April 2018: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29702230/adverse-events-of-fluoroquinolones-vs-other-antimicrobials-prescribed-in-primary-care-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#17
REVIEW
M Tandan, M Cormican, A Vellinga
BACKGROUND: Fluoroquinolones (FQs) are second line antimicrobial agents. Once the decision to prescribe an antimicrobial is made, its choice should be based on both the benefits and harms. This systematic review quantifies the occurrence of common adverse events (AEs) related to FQs in relation to any other antimicrobial for any indication in primary care. METHODS: We searched randomized controlled trials from Embase, PubMed, Cochrane Central Register of Controlled Trials and CINHAL...
April 24, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29697857/the-protective-effects-of-melatonin-and-glucagon-like-peptide-1-receptor-agonist-liraglutide-on-gastric-ischemia-reperfusion-injury-in-high-fat-sucrose-fed-rats
#18
Hanan A Mubarak, Manal M Mahmoud, Heba S Shoukry, Dina H Merzeban, Safinaz S Sayed, Laila A Rashed
Ischemia-reperfusion (I-R) injury is a serious pathology that is often encountered with thrombotic events, during surgery when blood vessels are cross-clamped, and in organs for transplantation. Increased oxidative stress is the main pathology in I-R injury, as assessed in studies on the heart, kidney, and brain with little data available on gastric I-R (GI-R). Liraglutide is a GLP-1receptor agonist that has insulinotropic and weight reducing actions, and melatonin that has much studied as a chronotropic hormone; have also studied as being antioxidative stress agents...
April 26, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29692453/controversies-in-the-management-of-cutaneous-adverse-drug-reactions
#19
Yashpal Manchanda, Sudip Das, Aarti Sarda, Projna Biswas
Some cutaneous adverse drug reactions (CADRs) are severe life-threatening conditions due to multisystem involvements with a high morbidity and mortality rates ranging from 25 - 70% and require immediate medical care. But there are huge controversies regarding the management because large clinical trials are lacking. Most frequent discussion and division occur regarding the use of systemic corticosteroid as early intervention with corticosteroids controls inflammation. Corticosteroids are potent agents that target several intracellular processes to modify almost all components of inflammatory and immune responses but their impact on the long term disease course is not known...
March 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29692451/unusual-and-interesting-adverse-cutaneous-drug-reactions
#20
Vaishali Masatkar, Ashok Nagure, Lalit Kumar Gupta
Any drug can cause any rash! Cutaneous adverse drug reactions (CADRs) are great mimickers and can be included in the differential diagnosis of any inflammatory dermatoses. Several drugs can cause rash of similar morphology and the same drug can cause rash of different morphology. While some common and specific drug reaction patterns are recognized easily by the clinicians, many a times unusual and interesting patterns can be induced by drug(s), thus leading to erroneous diagnosis and mistreatment. This review aims to familiarize clinicians with some rare, yet interesting patterns of CADR...
March 2018: Indian Journal of Dermatology
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