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https://www.readbyqxmd.com/read/28820392/orally-administered-angiotensin-converting-enzyme-inhibitors-captopril-and-isoleucine-proline-proline-have-distinct-effects-on-local-renin-angiotensin-system-and-corticosterone-synthesis-in-dextran-sulfate-sodium-induced-colitis-in-mice
#1
H Salmenkari, M Holappa, R A Forsgard, R Korpela, H Vapaatalo
The effects of angiotensin-converting enzyme (ACE) inhibition by an antihypertensive drug, captopril, and milk casein-derived ACE-inhibiting bioactive tripeptide isoleucine-proline-proline (Ile-Pro-Pro), on local renin-angiotensin system (RAS) and glucocorticoid production in the intestine were studied in the dextran sodium sulfate induced colitis in mice. Mice received water or 3% dextran sodium sulfate with or without either 15.7 mg/l captopril or 833 mg/l Ile-Pro-Pro for 7 days. Captopril and Ile-Pro-Pro were found to have distinct effects on local renin-angiotensin system and mRNA expression of glucocorticoid synthesis components in colon in vitro...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28820267/causes-and-significance-of-increased-compound-potency-in-cellular-or-physiological-contexts
#2
Adam G Schwaid, Ivan Cornella-Taracido
Compound potency is a key metric that is often used to drive medicinal chemistry programs. Compound potency is also taken into account when identifying the mechanism of action of compounds whose pharmacological target is unknown, particularly when these compounds are identified in phenotypic screens. Often compound potency is determined from assays using recombinantly generated, purified protein. It is well understood in the medicinal chemistry community that potency measured with recombinant enzyme and potency measured in cell may not entirely coincide...
August 18, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28814336/risk-behaviour-determinants-among-people-who-inject-drugs-in-stockholm-sweden-over-a-10-year-period-from-2002-to-2012
#3
Niklas Karlsson, Michele Santacatterina, Kerstin Käll, Maria Hägerstrand, Susanne Wallin, Torsten Berglund, Anna Mia Ekström
BACKGROUND: People who inject drugs (PWID) frequently engage in injection risk behaviours exposing them to blood-borne infections. Understanding the underlying causes that drive various types and levels of risk behaviours is important to better target preventive interventions. METHODS: A total of 2150 PWID in Swedish remand prisons were interviewed between 2002 and 2012. Questions on socio-demographic and drug-related variables were asked in relation to the following outcomes: Having shared injection drug solution and having lent out or having received already used drug injection equipment within a 12 month recall period...
August 16, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28814121/perceptions-of-iranian-female-drug-users-toward-hiv-testing-a-qualitative-content-analysis
#4
Mansoureh Jamshidimanesh, Effat Merghati Khoie, Seyed Abbas Mousavi, Afsaneh Keramat, Mohammad Hassan Emamian
BACKGROUND: Drug-dependent women are the vulnerable population deprived of access to health services and also have particular relevance to public health perspective because they are important bridge population for driving HIV/AIDS epidemic. This qualitative study aimed to explore the perception of drug-dependent women regarding HIV testing. METHODS: In this qualitative study, we approached 23 women with substance use disorders in 2 of the selected drop-in centers in the south Tehran...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28813473/the-availability-of-pharmacies-in-the-united-states-2007-2015
#5
Dima Mazen Qato, Shannon Zenk, Jocelyn Wilder, Rachel Harrington, Darrell Gaskin, G Caleb Alexander
IMPORTANCE: Despite their increasingly important role in health care delivery, little is known about the availability, and characteristics, of community pharmacies in the United States. OBJECTIVES: (1) To examine trends in the availability of community pharmacies and pharmacy characteristics (24-hour, drive-up, home delivery, e-prescribing, and multilingual staffing) associated with access to prescription medications in the U.S. between 2007 and 2015; and (2) to determine whether and how these patterns varied by pharmacy type (retail chains, independents, mass retailers, food stores, government and clinic-based) and across counties...
2017: PloS One
https://www.readbyqxmd.com/read/28812983/a-microfluidic-platform-for-modeling-metastatic-cancer-cell-matrix-invasion
#6
Laura Blaha, Chentian Zhang, Mario Cabodi, Joyce Y Wong
Invasion of the extracellular matrix is a critical step in the colonization of metastatic tumors. The invasion process is thought to be driven by both chemokine signaling and interactions between invading cancer cells and physical components of the metastatic niche, including endothelial cells that line capillary walls and serve as a barrier to both diffusion and invasion of the underlying tissue. Transwell chambers, a tool for generating artificial chemokine gradients to induce cell migration, have facilitated recent work to investigate the chemokine contributions to matrix invasion...
August 16, 2017: Biofabrication
https://www.readbyqxmd.com/read/28808046/car-t-cells-drive-cll-remissions
#7
(no author information available yet)
A new study shows that chimeric antigen receptor T cells produce objective responses in 71% of patients with chronic lymphocytic leukemia whose disease progressed despite receiving ibrutinib or who are unable to tolerate the drug. Cancer cells were undetectable in the bone marrow in 81% of tested patients, and 64% of tested patients showed complete lymph node responses. Most patients experienced adverse effects, however.
August 14, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28804137/pathogen-genetics-evolutionary-dynamics-driving-drug-resistance
#8
Linda Koch
No abstract text is available yet for this article.
August 14, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28803835/receptor-distribution-studies
#9
REVIEW
Renzo Carletti, Stefano Tacconi, Manolo Mugnaini, Philip Gerrard
Receptor distribution studies have played a key role in the characterization of receptor systems (e.g. GABAB, NMDA (GluNRs), and Neurokinin 1) and in generating hypotheses to exploit these systems as potential therapeutic targets. Distribution studies can provide important information on the potential role of candidate receptors in normal physiology/disease and alert for possible adverse effects of targeting the receptors. Moreover, they can provide valuable information relating to quantitative target engagement (e...
August 10, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28803496/management-of-multidrug-resistant-pseudomonas-aeruginosa-in-the-intensive-care-unit-state-of-the-art
#10
Alberto Enrico Maraolo, Marco Cascella, Silvia Corcione, Arturo Cuomo, Salvatore Nappa, Guglielmo Borgia, Francesco Giuseppe De Rosa, Ivan Gentile
Pseudomonas aeruginosa (PA) is one of the most important causes of healthcare-related infections among Gram-negative bacteria. The best therapeutic approach is controversial, especially for multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains as well as in the setting of most severe patients, such as in the intensive care unit (ICU). Areas covered: This article addresses several points. First, the main microbiological aspects of PA, focusing on its wide array of resistance mechanisms. Second, risk factors and the worse outcome linked to MDR-PA infection...
August 14, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28803259/opportunities-and-challenges-in-the-immunological-therapy-of-pediatric-malignancy-a-concise-snapshot
#11
REVIEW
Francesco Ceppi, Maja Beck-Popovic, Jean-Pierre Bourquin, Raffaele Renella
Over the last 50 years, collaborative clinical trials have reduced the number of children dying from pediatric cancer significantly. Unfortunately, certain tumor types have remained resistant to conventional surgical, radiotherapy and chemotherapy combinations, and relapsing and/or refractory disease remains associated with dismal outcomes. Recently, renewed attention has been given to the role for immunotherapies in pediatric oncology. In fact, these combine several attractive features, including (but possibly not limited to) the specificity for cancer cells, potentially in vivo persistence and longevity, and potency against refractory disease...
August 12, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28801108/breaching-barriers-in-glioblastoma-part-ii-targeted-drug-delivery-and-lipid-nanoparticles
#12
REVIEW
Ana Miranda, María Blanco-Prieto, João Sousa, Alberto Pais, Carla Vitorino
Tailored nanocarriers have gained huge research focus for brain drug delivery, aimed at combating several neuro-oncological conditions, such as the glioblastoma multiforme (GBM). The progress of knowledge on the pathogenesis of GBM has allowed identifying the major hurdles for efficient treatment, encompassing biological interfaces (blood-brain barrier and blood-brain tumour barrier), specificities of tumour microenvironment, as well as both bulk and glioma stem cell subpopulations. These findings provided new insights into the molecular basis of GBM, being a strong driving force behind development of targeted nanomedicines in this area...
August 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28800503/intravenous-heroin-use-in-haiphong-vietnam-need-for-comprehensive-care-including-methamphetamine-use-related-interventions
#13
Laurent Michel, Don C Des Jarlais, Huong Duong Thi, Oanh Khuat Thi Hai, Khuê Pham Minh, Marianne Peries, Roselyne Vallo, Thanh Nham Thi Tuyet, Giang Hoang Thi, Mai Le Sao, Jonathan Feelemyer, Vinh Vu Hai, Jean-Pierre Moles, Didier Laureillard, Nicolas Nagot
BACKGROUND: The aim of this study was to describe patterns among people who inject drugs (PWID), risk-related behaviours and access to methadone treatment, in order to design a large-scale intervention aiming to end the HIV epidemic in Haiphong, Vietnam. METHODS: A respondent-driven sampling (RDS) survey was first conducted to identify profiles of drug use and HIV risk-related behaviour among PWID. A sample of PWID was then included in a one-year cohort study to describe access to methadone treatment and associated factors...
August 2, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28795399/new-pharmacogenomics-research-network-an-open-community-catalyzing-research-and-translation-in-precision-medicine
#14
M V Relling, R M Krauss, D M Roden, T E Klein, D M Fowler, N Terada, L Lin, M Riel-Mehan, T P Do, M Kubo, S W Yee, G T Johnson, K M Giacomini
The goal of pharmacogenomics research is to discover genetic polymorphisms that underlie variation in drug response. Increasingly, pharmacogenomics research involves large numbers of patients and the application of new technologies and methodologies to enable discovery. The Pharmacogenomics Research Network (PGRN) has become a community-driven network of investigators spanning scientific and clinical disciplines. Here, we highlight the activities and types of resources that enable PGRN members to enhance and drive basic and translational research in pharmacogenomics...
August 10, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28795381/research-progress-on-prevention-and-treatment-of-glucolipid-metabolic-disease-with-integrated-traditional-chinese-and-western-medicine
#15
Jiao Guo
Hyperlipidemia, type 2 diabetes mellitus, nonalcoholic fatty liver and many other metabolic disorder are frequently co-existing in patients. In addition, these diseases are closely related in pathophysiological settings. However, increasing of the disease incidence, lacking of comprehensive prevention and control measurements against the key pathology point concomitant occurrence with the pattern of the single disease, single target therapy, that is leading therapeutic strategy for these metabolic disorders in the setting of Western medicine (WM)...
June 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28794807/prognostic-and-predictive-biomarkers-in-prostate-cancer-latest-evidence-and-clinical-implications
#16
REVIEW
Naoki Terada, Shusuke Akamatsu, Takashi Kobayashi, Takahiro Inoue, Osamu Ogawa, Emmanuel S Antonarakis
Advances in our understanding of the mechanisms driving castration-resistant prostate cancer have promoted the development of several new drugs including androgen receptor-directed therapy and chemotherapy. Concomitant docetaxel treatment at the beginning of hormonal therapy for metastatic prostate cancer has resulted in longer overall survival than with hormonal therapy alone. Elucidating an appropriate treatment sequence using these therapies is important for maximizing clinical benefit in castration-sensitive and castration-resistant prostate cancer patients...
August 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/28790501/conquering-the-challenges-of-genotypic-and-phenotypic-tumor-heterogeneity-to-realize-the-promise-of-personalized-cancer-therapy-the-role-of-academia
#17
Sofia Merajver, Sameer Phadke, Matthew Soellner
The advent of rapid and progressively more affordable sequencing and gene expression studies have spurred research on therapies for cancer targeted to specific gene alterations. With few exceptions, such as those cancers with either a paucity of mutations or major chromosomal rearrangements driving the neoplastic transformation, the approaches based on one mutational target-one drug have achieved only modest outcomes in cancer. Using the paradigm of aggressive breast cancers, we will show the mathematical explanation that predicts our failures and indicates a plausible way forward...
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28783169/glioblastoma-stem-cells-exploit-the-%C3%AE-v%C3%AE-8-integrin-tgf%C3%AE-1-signaling-axis-to-drive-tumor-initiation-and-progression
#18
P A Guerrero, J H Tchaicha, Z Chen, J E Morales, N McCarty, Q Wang, E P Sulman, G Fuller, F F Lang, G Rao, J H McCarty
Glioblastoma (GBM) is a primary brain cancer that contains populations of stem-like cancer cells (GSCs) that home to specialized perivascular niches. GSC interactions with their niche influence self-renewal, differentiation and drug resistance, although the pathways underlying these events remain largely unknown. Here, we report that the integrin αvβ8 and its latent transforming growth factor β1 (TGFβ1) protein ligand have central roles in promoting niche co-option and GBM initiation. αvβ8 integrin is highly expressed in GSCs and is essential for self-renewal and lineage commitment in vitro...
August 7, 2017: Oncogene
https://www.readbyqxmd.com/read/28780319/cdk1-mediated-mitotic-phosphorylation-of-pbk-is-involved-in-cytokinesis-and-inhibits-its-oncogenic-activity
#19
Seth Stauffer, Yongji Zeng, Jiuli Zhou, Xingcheng Chen, Yuanhong Chen, Jixin Dong
PDZ-binding kinase (PBK) plays a major role in proliferation and in safeguarding mitotic fidelity in cancer cells. Frequently upregulated in many cancers, PBK drives tumorigenesis and metastasis. PBK has been shown to be phosphorylated in mitosis by cyclin-dependent kinase 1 (CDK1)/cyclin B, however, no studies have been done examining PBK mitotic phosphorylation in oncogenesis. Additionally to the previously identified Threonine-9 phosphorylation, we found that Threonine-24, Serine-32, and Serine-59 of PBK are also phosphorylated...
August 3, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28778032/prevalence-of-psychoactive-substances-alcohol-and-illicit-drugs-in-spanish-drivers-a-roadside-study-in-2015
#20
Antonia Domingo-Salvany, M Jesús Herrero, Beatriz Fernandez, Julio Perez, Pilar Del Real, Juan Carlos González-Luque, Rafael de la Torre
A survey was conducted during 2015 to monitor psychoactive substance use in a sample of drivers in Spanish roads and cities. Traffic police officers recruited drivers at sites carefully chosen to achieve representativeness of the driver population. A brief questionnaire included the date, time, and personal and driving patterns data. Alcohol use was ascertained through ethanol breath test at the roadside and considered positive if concentrations >0.05mg alcohol/L were detected. Four drug classes were assessed on-site through an oral fluid screening test that, if positive, was confirmed through a second oral fluid sample at a reference laboratory...
July 20, 2017: Forensic Science International
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