keyword
https://read.qxmd.com/read/38522715/cgphb2-involved-in-the-haemocyte-mitophagy-in-response-to-vibrio-splendidus-stimulation-in-pacific-oyster-crassostrea-gigas
#1
JOURNAL ARTICLE
Shurong Li, Jiejie Sun, Yinan Li, Xiaoqian Lv, Lingling Wang, Linsheng Song
Prohibitin2 (PHB2) is recently identified as a novel inner membrane mitophagy receptor to mediate mitophagy. In the present study, the function of CgPHB2 in mediating mitophagy in response to Vibrio splendidus stimulation was investigated in Crassostrea gigas. CgPHB2 protein was mainly distributed in the cytoplasm of three subpopulations of haemocytes. After V. splendidus stimulation, the expressions of CgPHB2 mRNA in haemocytes were up-regulated significantly at 6, 12 and 24 h, and the abundance of CgPHB2 protein was also enhanced at 12-24 h compared to control group...
March 22, 2024: Developmental and Comparative Immunology
https://read.qxmd.com/read/38521716/emerging-roles-of-mrg15-in-liver-metabolic-diseases
#2
JOURNAL ARTICLE
Cheng Tian, Xiaosong Gu, Chunping Jiang, Qiurong Ding
MORF4 (mortality factor on chromosome 4)-related gene 15 (MRG15) is a chromodomain protein that exists in various multiprotein complexes involved in transcription, DNA repair, and development. Here we summarize the recent advances involving MRG15 in modulating liver metabolism, both through its chromatin-binding capability and independently of it, highlighting MRG15 as a potential therapeutic target for liver metabolic diseases.
March 22, 2024: Trends in Molecular Medicine
https://read.qxmd.com/read/38521466/ddit3-chop-promotes-lps-atp-induced-pyroptosis-in-osteoblasts-via-mitophagy-inhibition
#3
JOURNAL ARTICLE
Zhipeng Dong, Beining Yang, Meie Jia, Chang Yang, Shuo Wang, Hailin Mu, Jiawei Wang
Inflammatory environments can trigger endoplasmic reticulum (ER) stress and lead to pyroptosis in various tissues and cells, including liver, brain, and immune cells. As a key factor of ER stress, DNA damage-inducible transcript 3 (DDIT3)/CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) is upregulated in osteoblasts during inflammatory stimulation. DDIT3/CHOP may therefore regulate osteoblast pyroptosis in inflammatory conditions. During this investigation, we found that lipopolysaccharides (LPS)/adenosine 5'-triphosphate (ATP) stimulation in vitro induced osteoblasts to undergo pyroptosis, and the expression of DDIT3/CHOP was increased during this process...
March 21, 2024: Biochimica et Biophysica Acta. Molecular Cell Research
https://read.qxmd.com/read/38519468/rab4a-directed-endosome-traffic-shapes-pro-inflammatory-mitochondrial-metabolism-in-t-cells-via-mitophagy-cd98-expression-and-kynurenine-sensitive-mtor-activation
#4
JOURNAL ARTICLE
Nick Huang, Thomas Winans, Brandon Wyman, Zachary Oaks, Tamas Faludi, Gourav Choudhary, Zhi-Wei Lai, Joshua Lewis, Miguel Beckford, Manuel Duarte, Daniel Krakko, Akshay Patel, Joy Park, Tiffany Caza, Mahsa Sadeghzadeh, Laurence Morel, Mark Haas, Frank Middleton, Katalin Banki, Andras Perl
Activation of the mechanistic target of rapamycin (mTOR) is a key metabolic checkpoint of pro-inflammatory T-cell development that contributes to the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE), however, the underlying mechanisms remain poorly understood. Here, we identify a functional role for Rab4A-directed endosome traffic in CD98 receptor recycling, mTOR activation, and accumulation of mitochondria that connect metabolic pathways with immune cell lineage development and lupus pathogenesis...
March 22, 2024: Nature Communications
https://read.qxmd.com/read/38482399/identification-and-validation-of-mitophagy-related-signatures-as-a-novel-prognostic-model-for-colorectal-cancer
#5
JOURNAL ARTICLE
Qing Ke, Yun Wang, Yanyan Deng, Jinjin Wang, Mengjiao Yuan, Aifeng Liang, Jin Wang, Qian Gong
BACKGROUND: Colorectal cancer (CRC) is one of the most commonly diagnosed cancers in the world. Mitophagy is associated with tumorigenesis and development of malignancy. However, the specific role of mitophagy has yet not been systematically explored in CRC. METHODS: The RNA-sequencing dataset of CRC from The Cancer Genome Atlas (TCGA) and microarray data of gene expression profiles of CRC from Gene Expression Omnibus (GEO) were downloaded. Mitophagy-related gene sets were obtained from the Pathway Unification database...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38474132/brain-region-specific-genes-form-the-major-pathways-featuring-their-basic-functional-role-their-implication-in-animal-chronic-stress-model
#6
JOURNAL ARTICLE
Vladimir Babenko, Olga Redina, Dmitry Smagin, Irina Kovalenko, Anna Galyamina, Natalia Kudryavtseva
The analysis of RNA-Sec data from murine bulk tissue samples taken from five brain regions associated with behavior and stress response was conducted. The focus was on the most contrasting brain region-specific genes (BRSG) sets in terms of their expression rates. These BRSGs are identified as genes with a distinct outlying (high) expression rate in a specific region compared to others used in the study. The analysis suggested that BRSG sets form non-randomly connected compact gene networks, which correspond to the major neuron-mediated functional processes or pathways in each brain region...
March 1, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38463988/the-nutrient-sensing-rag-gtpase-complex-in-b-cells-controls-humoral-immunity-via-tfeb-tfe3-dependent-mitochondrial-fitness
#7
Xingxing Zhu, Yue Wu, Yanfeng Li, Xian Zhou, Jens O Watzlawik, Yin Maggie Chen, Ariel L Raybuck, Daniel Billadeau, Virginia Shapiro, Wolfdieter Springer, Jie Sun, Mark R Boothby, Hu Zeng
During the humoral immune response, B cells undergo rapid metabolic reprogramming with a high demand for nutrients, which are vital to sustain the formation of the germinal centers (GCs). Rag-GTPases sense amino acid availability to modulate the mechanistic target of rapamycin complex 1 (mTORC1) pathway and suppress transcription factor EB (TFEB) and transcription factor enhancer 3 (TFE3), members of the microphthalmia (MiT/TFE) family of HLH-leucine zipper transcription factors. However, how Rag-GTPases coordinate amino acid sensing, mTORC1 activation, and TFEB/TFE3 activity in humoral immunity remains undefined...
March 1, 2024: bioRxiv
https://read.qxmd.com/read/38443986/non-cytopathic-bovine-viral-diarrhea-virus-bvdv-inhibits-innate-immune-responses-via-induction-of-mitophagy
#8
JOURNAL ARTICLE
Zhijun Li, Ying Zhang, Bao Zhao, Qinghong Xue, Chunjiang Wang, Siyu Wan, Jingyu Wang, Xiwen Chen, Xuefeng Qi
Bovine viral diarrhea virus (BVDV) belongs to the genus Pestivirus within the family Flaviviridae. Mitophagy plays important roles in virus-host interactions. Here, we provide evidence that non-cytopathic (NCP) BVDV shifts the balance of mitochondrial dynamics toward fission and induces mitophagy to inhibit innate immune responses. Mechanistically, NCP BVDV triggers the translocation of dynamin-related protein (Drp1) to mitochondria and stimulates its phosphorylation at Ser616, leading to mitochondrial fission...
March 5, 2024: Veterinary Research
https://read.qxmd.com/read/38441018/defective-mitophagy-impairs-response-to-inflammatory-activation-of-macrophage-like-cells
#9
JOURNAL ARTICLE
Alexander N Orekhov, Alexander D Zhuravlev, Andrey Y Vinokurov, Nikita G Nikiforov, Andrey V Omelchenko, Vasily N Sukhorukov, Vasily V Sinyov, Igor A Sobenin
BACKGROUND AND AIMS: The role of mitophagy in atherosclerosis has been extensively studied during the last few years. It was shown that mitophagy is involved in the regulation of macrophages, which are important players as immune cells in atherosclerosis development. In this study, we investigated the relationship between mitophagy and response to inflammatory stimulation of macrophage-like cells. Six cybrid cell lines with normal mitophagy, that is, increasing in response to stimulation, and 7 lines with defective mitophagy not responding to stimulation were obtained...
March 1, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38432537/transcriptome-analysis-provides-new-insights-into-the-immune-response-of-ruditapes-philippinarum-infected-with-vibrio-alginolyticus
#10
JOURNAL ARTICLE
Hongda Li, Hongtao Nie, Dongdong Li, Bing Wang, Zhongming Huo, Yanming Su, Xiwu Yan
Manila clam (Ruditapes philippinarum) is a bivalve species with commercial value, but it is easily infected by pathogenic microorganisms in aquaculture, which restricts the shellfish industry. Notably, the impact of Vibrio alginolyticus on clam culture is obvious. In this study, RNA-seq was performed to analyze clam hepatopancreas tissue in 48 h (challenge group, G48h) and 96 h (challenge group, G96h) after infection with V. alginolyticus and 0 h after injection of PBS (control group, C)...
March 1, 2024: Fish & Shellfish Immunology
https://read.qxmd.com/read/38430646/cuproptotic-nanoinducer-driven-proteotoxic-stress-potentiates-cancer-immunotherapy-by-activating-the-mtdna-cgas-sting-signaling
#11
JOURNAL ARTICLE
Xinying Yu, Bei Li, Jie Yan, Wenxi Li, Hao Tian, Guohao Wang, Songtao Zhou, Yunlu Dai
Proteotoxic stress, caused by the accumulation of abnormal unfolded or misfolded cellular proteins, can efficiently activate inflammatory innate immune response. Initiating the mitochondrial proteotoxic stress might go forward to enable the cytosolic release of intramitochondrial DNA (mtDNA) for the immune-related mtDNA-cGAS-STING activation, which however is easily eliminated by a cell self-protection, i.e., mitophagy. In light of this, a nanoinducer (PCM) is reported to trigger mitophagy-inhibited cuproptotic proteotoxicity...
February 26, 2024: Biomaterials
https://read.qxmd.com/read/38425502/mitochondrial-dna-leakage-triggers-inflammation-in-age-related-cardiovascular-diseases
#12
REVIEW
Wanyue Ding, Jingyu Chen, Lei Zhao, Shuang Wu, Xiaomei Chen, Hong Chen
Mitochondrial dysfunction is one of the hallmarks of cardiovascular aging. The leakage of mitochondrial DNA (mtDNA) is increased in senescent cells, which are resistant to programmed cell death such as apoptosis. Due to its similarity to prokaryotic DNA, mtDNA could be recognized by cellular DNA sensors and trigger innate immune responses, resulting in chronic inflammatory conditions during aging. The mechanisms include cGAS-STING signaling, TLR-9 and inflammasomes activation. Mitochondrial quality controls such as mitophagy could prevent mitochondria from triggering harmful inflammatory responses, but when this homeostasis is out of balance, mtDNA-induced inflammation could become pathogenic and contribute to age-related cardiovascular diseases...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38414629/bioinformatics-analysis-and-experimental-validation-of-mitochondrial-autophagy-genes-in-knee-osteoarthritis
#13
JOURNAL ARTICLE
Kuihan Tang, Li Sun, Long Chen, Xiaobo Feng, Jiarui Wu, Hao Guo, Yong Zheng
BACKGROUND: Mitochondrial autophagy is closely related to the pathogenesis of osteoarthritis, In order to explore the role of mitochondrial autophagy related genes in knee osteoarthritis (KOA) and its molecular mechanism. METHODS: KOA-related transcriptome data were extracted from the Gene Expression Omnibus (GEO) database. Differentially expressed mitochondrial autophagy gene (DEMGs) were screened in patients with KOA by differential expression analysis. The STRING website was used to construct a protein-protein interaction (PPI) network among DEMGs...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38404962/mitochondrial-bioenergetics-metabolism-and-beyond-in-pancreatic-%C3%AE-cells-and-diabetes
#14
REVIEW
Alejandra María Rivera Nieves, Brian Michael Wauford, Accalia Fu
In Type 1 and Type 2 diabetes, pancreatic β-cell survival and function are impaired. Additional etiologies of diabetes include dysfunction in insulin-sensing hepatic, muscle, and adipose tissues as well as immune cells. An important determinant of metabolic health across these various tissues is mitochondria function and structure. This review focuses on the role of mitochondria in diabetes pathogenesis, with a specific emphasis on pancreatic β-cells. These dynamic organelles are obligate for β-cell survival, function, replication, insulin production, and control over insulin release...
2024: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/38397465/constructing-and-evaluating-a-mitophagy-related-gene-prognostic-model-implications-for-immune-landscape-and-tumor-biology-in-lung-adenocarcinoma
#15
JOURNAL ARTICLE
Jin Wang, Kaifan Liu, Jiawen Li, Hailong Zhang, Xian Gong, Xiangrong Song, Meidan Wei, Yaoyu Hu, Jianxiang Li
Mitophagy, a conserved cellular mechanism, is crucial for cellular homeostasis through the selective clearance of impaired mitochondria. Its emerging role in cancer development has sparked interest, particularly in lung adenocarcinoma (LUAD). Our study aimed to construct a risk model based on mitophagy-related genes (MRGs) to predict survival outcomes, immune response, and chemotherapy sensitivity in LUAD patients. We mined the GeneCards database to identify MRGs and applied LASSO/Cox regression to formulate a prognostic model...
February 16, 2024: Biomolecules
https://read.qxmd.com/read/38386664/ubiquitin-ligase-parkin-regulates-the-stability-of-sars-cov-2-main-protease-and-suppresses-viral-replication
#16
JOURNAL ARTICLE
Li Zhou, Ruochuan Liu, Heather Pathak, Xiaoyu Wang, Geon H Jeong, Pratima Kumari, Mukesh Kumar, Jun Yin
The highly infectious coronavirus SARS-CoV-2 relies on the viral main protease (Mpro , also known as 3CLpro or Nsp5) to proteolytically process the polyproteins encoded by the viral genome for the release of functional units in the host cells to initiate viral replication. Mpro also interacts with host proteins of the innate immune pathways, such as IRF3 and STAT1, to suppress their activities and facilitate virus survival and proliferation. To identify the host mechanism for regulating Mpro , we screened various classes of E3 ubiquitin ligases and found that Parkin of the RING-between-RING family can induce the ubiquitination and degradation of Mpro in the cell...
February 22, 2024: ACS Infectious Diseases
https://read.qxmd.com/read/38375420/identification-of-mitophagy-related-hub-genes-during-the-progression-of-spinal-cord-injury-by-integrated-multinomial-bioinformatics-analysis
#17
JOURNAL ARTICLE
Zhihao Guo, Zihui Zhao, Xiaoge Wang, Jie Zhou, Jie Liu, Ward Plunet, Wenjie Ren, Linqiang Tian
Spinal cord injury (SCI) is a disturbance of peripheral and central nerve conduction that causes disability in sensory and motor function. Currently, there is no effective treatment for SCI. Mitophagy plays a vital role in mitochondrial quality control during various physiological and pathological processes. The study aimed to elucidate the role of mitophagy and identify potential mitophagy-related hub genes in SCI pathophysiology. Two datasets (GSE15878 and GSE138637) were analyzed. Firstly, the differentially expressed genes (DEGs) were identified and mitophagy-related genes were obtained from GeneCards, then the intersection between SCI and mitophagy-related genes was determined...
July 2024: Biochemistry and Biophysics Reports
https://read.qxmd.com/read/38374038/mechanism-and-role-of-mitophagy-in-the-development-of-severe-infection
#18
REVIEW
Lixiu Ma, Tianyu Han, Yi-An Zhan
Mitochondria produce adenosine triphosphate and potentially contribute to proinflammatory responses and cell death. Mitophagy, as a conservative phenomenon, scavenges waste mitochondria and their components in the cell. Recent studies suggest that severe infections develop alongside mitochondrial dysfunction and mitophagy abnormalities. Restoring mitophagy protects against excessive inflammation and multiple organ failure in sepsis. Here, we review the normal mitophagy process, its interaction with invading microorganisms and the immune system, and summarize the mechanism of mitophagy dysfunction during severe infection...
February 19, 2024: Cell Death Discovery
https://read.qxmd.com/read/38370419/hcv-induced-autophagy-and-innate-immunity
#19
REVIEW
Jiyoung Lee, J-H James Ou
The interplay between autophagy and host innate immunity has been of great interest. Hepatitis C virus (HCV) impedes signaling pathways initiated by pattern-recognition receptors (PRRs) that recognize pathogens-associated molecular patterns (PAMPs). Autophagy, a cellular catabolic process, delivers damaged organelles and protein aggregates to lysosomes for degradation and recycling. Autophagy is also an innate immune response of cells to trap pathogens in membrane vesicles for removal. However, HCV controls the autophagic pathway and uses autophagic membranes to enhance its replication...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38356715/genomic-analysis-of-hypoxia-and-mitophagy-related-genes-with-prognosis-and-characterization-of-the-immune-microenvironment-in-luad
#20
JOURNAL ARTICLE
Jinghao Liu, Hua Huang, Yueting Han, Yu Hua, Boshi Li, Hongyu Liu, Jun Chen
Background: Lung adenocarcinoma (LUAD) stands as a prominent subtype within the realm of non-small cell lung cancer and constitutes a primary contributor to cancer-related mortality on a global scale. Notably, hypoxia, a prevalent attribute within solid tumor environments, and mitophagy, a selective manifestation of autophagy dedicated to the removal of damaged mitochondria, have risen to prominence as pivotal factors influencing the initiation and advancement of tumorigenesis. Methods: This investigation harnessed publicly accessible genomic datasets encompassing LUAD patients to delineate genes linked to hypoxia and mitophagy, termed hereafter as hypoxia and mitophagy-related genes (HMRGs)...
2024: Journal of Cancer
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