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https://www.readbyqxmd.com/read/29135318/the-effect-and-safety-of-anacetrapib-in-the-treatment-of-dyslipidemia-a-systematic-review-and-meta-analysis
#1
Junteng Zhou, Qi Zhang, Yushu Wang, Peijuan Gao, Decai Chen
BACKGROUND: Cardiovascular disease (CVD) is the major cause of morbidity and mortality worldwide. Anacetrapib may be a new treatment option that has a cardiovascular benefit for the management of dyslipidemia. OBJECTIVE: The aim of our current study was to perform a systematic review and meta-analysis of all randomized controlled trials (RCTs) assessing the effect and safety of anacetrapib in the treatment of dyslipidemia. METHODS: We systematically searched PubMed, Embase, and Cochrane Library database from their inception to 5 October 2017, with the terms: 'anacetrapib' and 'placebo'...
November 14, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29126045/the-effectiveness-of-conservative-non-pharmacological-treatment-of-plantar-heel-pain-a-systematic-review-with-meta-analysis
#2
REVIEW
Stefano Salvioli, Maddalena Guidi, Giulia Marcotulli
Plantar heel pain is one of the most common causes of pain and musculoskeletal pathologies of the foot. The aim of this systematic review was to identify the most effective, conservative and non-pharmacological treatments regarding pain in patients with plantar heel pain. The authors searched 5 databases and included only randomized control trials which investigated the efficacy of a conservative non-pharmacological treatment compared to the placebo, for the outcome of pain. Study selection, data collection and risk of bias assessment were conducted independently by two authors, and consensus was reached with a third author...
June 15, 2017: Foot
https://www.readbyqxmd.com/read/29122652/how-can-we-best-reduce-pain-catastrophizing-in-adults-with-chronic-non-cancer-pain-a-systematic-review-and-meta-analysis
#3
REVIEW
Robert Schütze, Clare Rees, Anne Smith, Helen Slater, Jared M Campbell, Peter O'Sullivan
Pain catastrophizing (PC), defined as an exaggerated negative cognitive-affective orientation toward pain, is one of the strongest psychological predictors of pain outcomes. While regularly included as a process variable in clinical trials, there have been no comprehensive reviews of how it can be modified. Using a registered protocol (PROSPERO 2016 CRD42016042761), we searched MEDLINE, PsychINFO, EMBASE, CINAHL, and CENTRAL up to November 2016 for all randomized controlled trials measuring PC in adults with chronic non-cancer pain...
November 6, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29122581/physical-activity-based-interventions-using-electronic-feedback-may-be-ineffective-for-reducing-pain-and-disability-in-patients-with-chronic-musculoskeletal-pain-a-systematic-review-with-meta-analysis
#4
REVIEW
Crystian B Oliveira, Márcia R Franco, Chris G Maher, Paulo H Ferreira, Priscila K Morelhão, Tatiana M Damato, Cynthia Gobbi, Rafael Z Pinto
OBJECTIVE: To investigate the effectiveness of physical activity-based interventions using electronic feedback to reduce pain and disability compared to minimal or no interventions in patients with chronic musculoskeletal pain. DESIGN: Systematic review with meta-analysis DATA SOURCES: The following electronic databases were searched: EMBASE, MEDLINE, the Cochrane Central Register of Controlled Trials, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, SPORTDiscus, Web of Science, Physiotherapy Evidence Database (PEDro), and main clinical trial registers...
November 6, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29115188/sit-stand-workstations-and-impact-on-low-back-discomfort-a-systematic-review-and-meta-analysis
#5
Shuchi Agarwal, Craig Steinmaus, Carisa Harris-Adamson
BACKGROUND: Sit-stand workstations are proposed solutions to reduce sedentary time at work. Numerous companies are using them to mitigate health concerns such as musculoskeletal discomfort. OBJECTIVE: To review the literature on sit-stand workstations and low back discomfort. METHOD: We conducted a meta-analysis on literature published before November 17, 2016 that addressed the relationship between sit-stand workstations and musculoskeletal discomfort, focusing on the low back...
November 8, 2017: Ergonomics
https://www.readbyqxmd.com/read/29100499/the-role-of-psychosocial-stress-in-the-development-of-chronic-musculoskeletal-pain-disorders-protocol-for-a-systematic-review-and-meta-analysis
#6
Valentina Buscemi, Wei-Ju Chang, Matthew B Liston, James H McAuley, Siobhan Schabrun
BACKGROUND: Psychosocial factors play an important role in chronic musculoskeletal pain disorders. Although psychosocial stress is likely to contribute to the development of chronic musculoskeletal pain, investigations are limited to work-related stress or examination of specific conditions such as upper limb pain. The purpose of this review is to assess the evidence for an aetiological role of psychological stress in chronic musculoskeletal pain disorders. METHODS: A systematic review and meta-analysis will be conducted...
November 3, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29090335/the-prevalence-of-musculoskeletal-symptoms-in-the-construction-industry-a-systematic-review-and-meta-analysis
#7
Waleed Umer, Maxwell F Antwi-Afari, Heng Li, Grace P Y Szeto, Arnold Y L Wong
PURPOSE: Although individual studies have reported high prevalence of musculoskeletal symptoms (MSS) among construction workers, no systematic review has summarized their prevalence rates. Accordingly, this systematic review/meta-analysis aimed to synthesize MSS prevalence in different construction trades, gender and age groups, which may help develop specific ergonomic interventions. METHODS: Nine databases were searched for articles related to the research objective...
October 31, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29047337/prevalence-and-incidence-of-musculoskeletal-extremity-complaints-in-children-and-adolescents-a-systematic-review
#8
Signe Fuglkjær, Kristina Boe Dissing, Lise Hestbæk
BACKGROUND: It is difficult to gain an overview of musculoskeletal extremity complaints in childhood although this is essential to develop evidence-based prevention and treatment strategies. The objectives of this systematic review were therefore to describe the prevalence and incidence of musculoskeletal extremity complaints in children and adolescents in both general and clinical populations in relation to age, anatomical site and mode of onset. METHODS: MEDLINE and EMBASE were electronically searched; risk of bias was assessed; and data extraction was individually performed by two authors...
October 18, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29036866/the-prevalence-of-occupational-musculoskeletal-disorders-in-iran-a-meta-analysis-study
#9
Ayub Parno, Kourosh Sayehmiri, Mohsen Parno, Mohammad Khandan, Mohsen Poursadeghiyan, Maryam Maghsoudipour, Mohammad Hossein Ebrahimi
BACKGROUND: Prevention of Work-Related Musculoskeletal Disorders (WRMSDs) is crucial as they jeopardize the well-being of the workforce in workplaces and are prevalent in developed and developing countries. OBJECTIVE: This study aimed to determine the prevalence of WRMSDs among Iranian workers. METHODS: A systematic review and meta-analysis of WRMSDs in Iran was performed by searching relevant keywords in authentic databases and search engines such as SID, Google Scholar, Medlib and PubMed...
2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29026323/diagnostic-accuracy-of-xpert-mtb-rif-assay-for-musculoskeletal-tuberculosis-a-meta-analysis
#10
REVIEW
Hai Wen, Pengzhi Li, Hong Ma, Guohua Lv
OBJECTIVES: Xpert MTB/RIF assay, a rapid and automated real-time nucleic acid amplification test, has been reported for the diagnosis of musculoskeletal tuberculosis (TB) in current years. This meta-analysis aims to determine the diagnostic accuracy of Xpert for the detection of musculoskeletal TB and rifampicin (RIF) resistance. METHODS: We searched PubMed, Embase, China National Knowledge Infrastructure, and Wanfang for original articles published up to 1st June 2017 to identify studies in which the Xpert assay was applied to diagnose musculoskeletal TB...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29020989/predictors-of-multidisciplinary-rehabilitation-outcomes-in-patients-with-chronic-musculoskeletal-pain-protocol-for-a-systematic-review-and-meta-analysis
#11
Elena Tseli, Wilhelmus Johannes Andreas Grooten, Britt-Marie Stålnacke, Katja Boersma, Paul Enthoven, Björn Gerdle, Björn Olov Äng
BACKGROUND: Chronic musculoskeletal pain is a major public health problem. Early prediction for optimal treatment results has received growing attention, but there is presently a lack of evidence regarding what information such proactive management should be based on. This study protocol, therefore, presents our planned systematic review and meta-analysis on important predictive factors for health and work-related outcomes following multidisciplinary rehabilitation (MDR) in patients with chronic musculoskeletal pain...
October 11, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29018544/verbal-augmented-feedback-in-the-rehabilitation-of-lower-extremity-musculoskeletal-dysfunctions-a-systematic-review
#12
REVIEW
Marianne Storberget, Linn Helen J Grødahl, Suzanne Snodgrass, Paulette van Vliet, Nicola Heneghan
BACKGROUND: Verbal augmented feedback (VAF) is commonly used in physiotherapy rehabilitation of individuals with lower extremity musculoskeletal dysfunction or to induce motor learning for injury prevention. Its effectiveness for acquisition, retention and transfer of learning of new skills in this population is unknown. OBJECTIVES: First, to investigate the effect of VAF for rehabilitation and prevention of lower extremity musculoskeletal dysfunction. Second, to determine its effect on motor learning and the stages of acquisition, retention and transfer in this population...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28990575/a-systematic-review-of-the-concept-and-clinical-applications-of-bone-marrow-aspirate-concentrate-in-tendon-pathology
#13
Mohamed A Imam, James Holton, Saman Horriat, Ahmed S Negida, Florian Grubhofer, Rohit Gupta, Ali Narvani, Martyn Snow
Tendon pathologies are a group of musculoskeletal conditions frequently seen in clinical practice. They can be broadly classified into traumatic, degenerative and overuse-related tendinopathies. Rotator cuff tears, Achilles tendinopathy and tennis elbow are common examples of these conditions. Conventional treatments have shown inconsistent outcomes and might fail to provide satisfactory clinical improvement. With the growing trend towards the use of mesenchymal stem cells (MSCs) in other branches of medicine, there is an increasing interest in treating tendon pathologies using the bone marrow MSC...
2017: SICOT-J
https://www.readbyqxmd.com/read/28990574/an-evidence-based-evaluation-on-the-use-of-platelet-rich-plasma-in-orthopedics-a-review-of-the-literature
#14
Nasir Hussain, Herman Johal, Mohit Bhandari
Within orthopedics, the use of platelet-rich plasma (PRP) has been rapidly increasing in popularity, however, its true effectiveness has yet to be fully established. Several studies find that injecting PRP to the site of injury does not provide any significant benefit with respect to clinical outcomes; however, many others report the contrary. Due to the conflicting evidence and multiple meta-analyses conducted on the topic, a literature review of high-quality evidence on the use of PRP for common orthopaedic conditions was performed...
2017: SICOT-J
https://www.readbyqxmd.com/read/28988517/developing-and-testing-a-consensus-based-core-set-of-outcome-measures-for-rehabilitation-in-musculoskeletal-diseases
#15
M Klokkerud, H Dagfinrud, T Uhlig, T N Dager, K-A Furunes, Å Klokkeide, M Larsen, S Nygård, S Nylenna, L Øie, I Kjeken
OBJECTIVES: Rehabilitation is important for people with musculoskeletal diseases (MSDs), and evaluating the effect of rehabilitation on both an individual and group level is advocated. A consensus concerning use of outcome measures will improve collaboration between healthcare providers, and increase the possibility of conducting meta-analyses in future research. The aim of this study was to develop a consensus-based core set of outcome measures for rehabilitation in MSDs, and to test the feasibility and responsiveness of the set...
October 9, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28986742/treatment-strategies-for-central-low-grade-chondrosarcoma-of-long-bones-a-systematic-review-of-the-literature-and-meta-analysis
#16
REVIEW
S S Shemesh, J D Acevedo-Nieves, J Pretell-Mazzini
The need for wide local excision (WLE) versus intralesional (IL) treatment of low-grade chondrosarcomas (CS) of the appendicular skeleton remains controversial. We sought to perform a systematic review and meta-analysis to compare different conventional types of surgical treatments for grade I CS in terms of: (1) rate of local recurrence (LR) and metastases, (2) functional outcome as measured by the Musculoskeletal Tumor Society (MSTS) score, (3) complication rate. Eighteen studies enrolling 695 patients met our criteria...
October 6, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28977041/physical-psychological-and-occupational-consequences-of-job-burnout-a-systematic-review-of-prospective-studies
#17
REVIEW
Denise Albieri Jodas Salvagioni, Francine Nesello Melanda, Arthur Eumann Mesas, Alberto Durán González, Flávia Lopes Gabani, Selma Maffei de Andrade
Burnout is a syndrome that results from chronic stress at work, with several consequences to workers' well-being and health. This systematic review aimed to summarize the evidence of the physical, psychological and occupational consequences of job burnout in prospective studies. The PubMed, Science Direct, PsycInfo, SciELO, LILACS and Web of Science databases were searched without language or date restrictions. The Transparent Reporting of Systematic Reviews and Meta-Analyses guidelines were followed. Prospective studies that analyzed burnout as the exposure condition were included...
2017: PloS One
https://www.readbyqxmd.com/read/28964279/pediatric-primary-sj%C3%A3-gren-syndrome-presenting-with-bilateral-ranulas-a-case-report-and-systematic-review-of-the-literature
#18
REVIEW
Casey Means, Mark A Aldape, Ericka King
CONTEXT: Primary Sjögren syndrome is uncommon in children, and the standard clinical criteria used in diagnosis of adult Sjögren syndrome will miss many children with the disease. Floor of mouth ranulas have not been described in Sjögren syndrome. OBJECTIVE: This study aims to describe a novel presentation of juvenile primary Sjögren syndrome, and to present a comprehensive systematic review of the literature regarding the presentation and diagnosis of Sjögren syndrome in children...
October 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28943224/the-effect-of-lipophilicity-and-dose-on-the-frequency-of-statin-associated-muscle-symptoms-a-systematic-review-and-meta-analysis
#19
REVIEW
Jordon C Irwin, Saman Khalesi, Andrew S Fenning, Rebecca K Vella
Addressing the factors which lead to the development of statin-associated muscle symptoms (SAMS) is vital for maintaining patient compliance with these pharmaceuticals, and thus improving patient outcomes. This study aimed to clarify the relationship between statin lipophilicity, or dose, and the frequency of adverse muscle symptoms using a systematic review of randomised controlled trials (RCTs). RCTs, including statin monotherapy and placebo groups, which reported data on muscle adverse events were identified through the PubMed and Scopus databases...
September 21, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28925663/top-poems-of-2016-consistent-with-the-principles-of-the-choosing-wisely-campaign
#20
Roland Grad, Mark H Ebell
A challenge in the Choosing Wisely campaign is to identify low-value clinical actions supported by high-quality evidence. We applied a method based on crowdsourcing the Daily POEM (patient-oriented evidence that matters) to identify low-value clinical actions from research studies consistent with the principles of Choosing Wisely. In 2016, we analyzed an average of 1,382 questionnaires on 265 unique POEMs delivered to physician members of the Canadian Medical Association. From these questionnaires, we identified the POEMs ranking highest on one questionnaire item directly linked to reducing overdiagnosis or overtreatment...
August 15, 2017: American Family Physician
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