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https://www.readbyqxmd.com/read/28817948/effects-of-dietary-supplementation-of-resveratrol-on-performance-egg-quality-yolk-cholesterol-and-antioxidant-enzyme-activity-of-laying-hens
#1
Z H Feng, J G Gong, G X Zhao, X Lin, Y C Liu, K W Ma
1. This experiment was conducted to evaluate the effects of dietary supplementation of resveratrol on laying performance, egg quality, egg yolk cholesterol and antioxidant enzyme activities of laying hens. 2. A total of 360 Beijing PINK-1 laying hens (60 weeks old) were randomly distributed among 5 dietary treatments, each of which included 6 replicates of 12 hens. Dietary treatments were basal diet supplemented with 0 (control), 0.5, 1.0, 2.0 and 4.0 g/kg diet resveratrol. The study lasted for 9 weeks including 1 week of adaptation and 8 weeks of the main experimental period...
August 18, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28816548/dietary-supplementation-with-virgin-coconut-oil-improves-lipid-profile-and-hepatic-antioxidant-status-and-has-potential-benefits-on-cardiovascular-risk-indices-in-normal-rats
#2
Ademola C Famurewa, Chima A Ekeleme-Egedigwe, Sophia C Nwali, Ngozi N Agbo, Joy N Obi, Goodness C Ezechukwu
Research findings that suggest beneficial health effects of dietary supplementation with virgin coconut oil (VCO) are limited in the published literature. This study investigated the in vivo effects of a 5-week VCO-supplemented diet on lipid profile, hepatic antioxidant status, hepatorenal function, and cardiovascular risk indices in normal rats. Rats were randomly divided into 3 groups: 1 control and 2 treatment groups (10% and 15% VCO-supplemented diets) for 5 weeks. Serum and homogenate samples were used to analyze lipid profile, hepatorenal function markers, hepatic activities of antioxidant enzymes, and malondialdehyde level...
August 17, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28806986/antihyperlipidaemic-and-hepatoprotective-activities-of-acidic-and-enzymatic-hydrolysis-exopolysaccharides-from-pleurotus-eryngii-si-04
#3
Chen Zhang, Juan Li, Jing Wang, Xingling Song, Jianjun Zhang, Shang Wu, Chunlong Hu, Zhiyuan Gong, Le Jia
BACKGROUND: Hyperlipidaemia is the major risk factor contributing to the development and progression of atherosclerosis, fatty liver and cerebrovascular disease. Pleurotus eryngii (P. eryngii) is rich in biologically active components, especially polysaccharides that exhibit various biological activities, including reducing blood lipids. In the present study, three novel polysaccharide types, including exopolysaccharides (EPS), enzymatic EPS (EEPS) and acidic EPS (AEPS) were isolated, and the hypolipidaemic and hepatoprotective effects were investigated to better understand possible hypolipidaemic mechanisms and their hepatoprotective effects...
August 14, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28792690/evaluation-of-malondialdehyde-low-density-lipoprotein-stratified-by-low-density-lipoprotein-cholesterol
#4
Kengo Moriyama, Eiko Takahashi
BACKGROUND: Malondialdehyde low-density lipoprotein (MDA-LDL) is a major form of oxidized LDL and considered to be more atherogenic than LDL. Information on major determinants of MDA-LDL and their association in subjects who are not under treatment for diabetes mellitus and dyslipidemia is limited. METHODS: This study included 778 Japanese subjects who were not taking medication for diabetes mellitus and dyslipidemia. All subjects underwent an annual health examination that included MDA-LDL analysis...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28761829/effects-of-pomegranate-punica-granatum-l-seed-and-peel-methanolic-extracts-on-oxidative-stress-and-lipid-profile-changes-induced-by-methotrexate-in-rats
#5
Farideh Doostan, Roxana Vafafar, Parvin Zakeri-Milani, Aliasghar Pouri, Rogayeh Amini Afshar, Mehran Mesgari Abbasi
Purpose: Methotrexate (MTX) is prescribed in many diseases and can result in oxidative stress (OS) followed by injuries in some tissues. Antioxidants administration are effective in reducing OS. Pomegranate exhibits high anti-oxidant capacities. This study investigated whether pomegranate seed and peel methanolic extracts (PSE and PPE) could protect against MTX-induced OS and lipid profile changes in rats. Methods: Forty-eight rats were randomly divided into 6 groups: control group (normal salin), PSE group (500 mg/kg, orally), PPE group (500 mg/kg, orally), MTX group (10 mg/kg, IM), MTX and PSE group, and MTX and PPE group...
June 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28759039/elevated-tumor-ldlr-expression-accelerates-ldl-cholesterol-mediated-breast-cancer-growth-in-mouse-models-of-hyperlipidemia
#6
E J Gallagher, Z Zelenko, B A Neel, I M Antoniou, L Rajan, N Kase, D LeRoith
Obesity is associated with an increase in cancer-specific mortality in women with breast cancer. Elevated cholesterol, particularly low-density lipoprotein cholesterol (LDL-C), is frequently seen in obese women. Here, we aimed to determine the importance of elevated circulating LDL, and LDL receptor (LDLR) expression in tumor cells, on the growth of breast cancer using mouse models of hyperlipidemia. We describe two novel immunodeficient mouse models of hyperlipidemia (Rag1(-/)(-)/LDLR(-/)(-) and Rag1(-/)(-)/ApoE (apolipoprotein E)(-/)(-) mice) in addition to established immunocompetent LDLR(-/)(-) and ApoE(-/)(-) mice...
July 31, 2017: Oncogene
https://www.readbyqxmd.com/read/28755576/hepatoprotective-effect-of-opuntia-microdasys-lehm-pfeiff-flowers-against-diabetes-type-ii-induced-in-rats
#7
Hassiba Chahdoura, Khawla Adouni, Aida Khlifi, Ichrak Dridi, Zohra Haouas, Fadoua Neffati, Guido Flamini, Habib Mosbah, Lotfi Achour
Opuntia sp. has long been used as a folk medicine to treat hepatitis and diabetes in Sicile (Italy). To extract the polyphenols from the flower of Opuntia microdasys Lehm. at post flowring stage and evaluate the antidiabetic activity in vitro and in vivo. The hepatoprotective activity of Opuntia microdasys aqueous flowers extract at post flowering stage (OFP) has been tested for their antidiabetic activity. On fructose-alloxan induced diabete in rat model, evaluating the inhibitory effects of OFP on some carbohydrate metabolizing enzymes, pancreatic α-amylase and intestinal α-glucosidase activities in vitro...
July 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28734952/potential-predictive-role-of-lipid-peroxidation-markers-for-type-2-diabetes-in-the-tunisian-population
#8
Houda Bouhajja, Faten Hadj Kacem, Rania Abdelhedi, Marwa Ncir, Jordan D Dimitrov, Rim Marrakchi, Kamel Jamoussi, Ahmed Rebai, Abdelfattah El Feki, Mohamed Abid, Hammadi Ayadi, Srini V Kaveri, Mouna Mnif-Feki, Noura Bougacha-Elleuch
OBJECTIVES: We evaluated the potential clinical relevance of malondialdehyde (MDA) and autoantibodies to copper oxidized low-density lipoprotein (CuOx-LDL) in type 2 diabetes occurrence. METHODS: This cross-sectional study enrolled 69 normoglycemic subjects, 18 prediabetic patients and 108 type 2 diabetes patients. MDA concentration was assessed spectrophotometrically. Plasma IgG, IgA and IgM levels to CuOx-LDL were determined by ELISA. RESULTS: Plasma MDA levels were considerably higher in obese, prediabetic and type 2 diabetes subjects compared to controls...
July 19, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28718838/phyllanthus-niruri-standardized-extract-alleviates-the-progression-of-non-alcoholic-fatty-liver-disease-and-decreases-atherosclerotic-risk-in-sprague-dawley-rats
#9
Raghdaa Hamdan Al Zarzour, Mariam Ahmad, Mohd Zaini Asmawi, Gurjeet Kaur, Mohammed Ali Ahmed Saeed, Majed Ahmed Al-Mansoub, Sultan Ayesh Mohammed Saghir, Nasiba Salisu Usman, Dhamraa W Al-Dulaimi, Mun Fei Yam
Non-alcoholic fatty liver disease (NAFLD) is one of the major global health issues, strongly correlated with insulin resistance, obesity and oxidative stress. The current study aimed to evaluate anti-NAFLD effects of three different extracts of Phyllanthus niruri (P. niruri). NAFLD was induced in male Sprague-Dawley rats using a special high-fat diet (HFD). A 50% methanolic extract (50% ME) exhibited the highest inhibitory effect against NAFLD progression. It significantly reduced hepatomegaly (16%) and visceral fat weight (22%), decreased NAFLD score, prevented fibrosis, and reduced serum total cholesterol (TC) (48%), low-density lipoprotein (LDL) (65%), free fatty acids (FFAs) (25%), alanine aminotransferase (ALT) (45%), alkaline phosphatase (ALP) (38%), insulin concentration (67%), homeostatic model assessment of insulin resistance (HOMA-IR) (73%), serum atherogenic ratios TC/high-density lipoprotein (HDL) (29%), LDL/HDL (66%) and (TC-HDL)/HDL (64%), hepatic content of cholesterol (43%), triglyceride (29%) and malondialdehyde (MDA) (40%) compared to a non-treated HFD group...
July 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28707864/oxidative-stress-antioxidants-and-lipid-profile-in-the-serum-and-saliva-of-individuals-with-coronary-heart-disease-is-there-a-link-with-periodontal-health
#10
Natheer H Al-Rawi, Alaa M Shahid
BACKGROUND: Oxidative stresses and dyslipidemia are an important risk factor in the development of coronary atherosclerotic complications like angina pectoris and myocardial infarction. The aim of this study was to find the relationship between the salivary lipid profile, lipid peroxidation and antioxidants and the periodontal health status of patients with acute coronary heart disease. METHODS: Forty s who had experienced a recent attack of angina pectoris or myocardial infarction and another 40 noncardiac patients matched for age, sex and residence (control) were recruited...
July 12, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28695324/the-effect-of-almonds-on-vitamin-e-status-and-cardiovascular-risk-factors-in-korean-adults-a-randomized-clinical-trial
#11
Hana Jung, C-Y Oliver Chen, Jeffrey B Blumberg, Ho-Kyung Kwak
PURPOSE: Almonds have shown to beneficially modify some cardiovascular risk factors in clinical trials conducted in diverse ethnic populations but this relationship has never been tested in Koreans. Thus, we tested the impact of almonds consumed as a snack within the context of a typical Korean diet on cardiovascular risk factors. METHODS: We conducted a randomized, crossover trial in a free-living setting with a 2-week run-in period, two 4-week intervention phases, and a 2-week washout period between interventions...
July 10, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28689783/immune-complexes-containing-malondialdehyde-mda-ldl-induce-apoptosis-in-human-macrophages
#12
Gabriel Virella, Kelsey Wilson, Johnathon Elkes, Samar M Hammad, Hussein A Rajab, Yanchun Li, Charlyne Chassereau, Yan Huang, Maria Lopes-Virella
Immune complexes (IC) containing predominantly malondialdehyde-LDL and the corresponding autoantibodies (MDA-LDL IC) predict acute cardiovascular events, while IC rich in oxidized LDL (oxLDL IC) predict cardiovascular disease progression. Our objective was to determine mechanisms that could explain these prognostic differences. We compared the effects of the interaction of oxLDL, MDA-LDL and the corresponding IC with human macrophages focusing on apoptosis, metalloproteinases, and proinflammatory cytokines...
July 6, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28688900/mir-34a-sirtuin-1-foxo3a-is-involved-in-genistein-protecting-against-ox-ldl-induced-oxidative-damage-in-huvecs
#13
Huaping Zhang, Zhenxiang Zhao, Xuefen Pang, Jian Yang, Haixia Yu, Yinhong Zhang, Hui Zhou, Jiahui Zhao
The antioxidant activity of genistein is associated with preventing atherosclerosis; however, the underlying mechanisms are not fully understood. In this study, human umbilical vein endothelial cells (HUVECs) were pretreated with genistein at different concentrations (10nM, 100nM and 1000nM) for 6h and then exposed to ox-LDL (50mg/L) for another 24h. Results showed that genistein restrained reactive oxygen species (ROS) and malondialdehyde (MDA) production, and ameliorated the inhibitory effect on superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione peroxidase (GPx) activity elicited by ox-LDL stimulation...
August 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28651186/circulating-malondialdehyde-modified-low-density-lipoprotein-mda-ldl-as-a-novel-predictor-of-clinical-outcome-after-endovascular-therapy-in-patients-with-peripheral-artery-disease-pad
#14
Taka-Aki Takamura, Taketsugu Tsuchiya, Minako Oda, Makoto Watanabe, Ryuhei Saito, Ryoko Sato-Ishida, Hironobu Akao, Yasuyuki Kawai, Michihiko Kitayama, Kouji Kajinami
BACKGROUND AND AIMS: Despite advances in the treatment of peripheral artery disease (PAD), cardiovascular events and death rates remain high. This study aimed at identifying markers of outcome in patients with PAD undergoing endovascular therapy (EVT). METHODS: Consecutive patients undergoing EVT were recruited. Markers of oxidative stress (malondialdehyde-modified low-density lipoprotein [MDA-LDL]), inflammation (IL-6; high-sensitivity C-reactive protein [hsCRP]) and fibrinolysis (D-dimer) were measured pre-EVT and at post-EVT time-points to 36 h...
June 16, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28650494/chemical-characteristics-of-an-ilex-kuding-tea-polysaccharide-and-its-protective-effects-against-high-fructose-induced-liver-injury-and-vascular-endothelial-dysfunction-in-mice
#15
Xichuan Zhai, Daoyuan Ren, Yiyang Luo, Yuanyuan Hu, Xingbin Yang
The present study was designed to investigate the protective effects of Ilex Kuding tea polysaccharides (IKTP) on high fructose (HF)-induced liver injury and vascular endothelial dysfunction in mice. IKTP were identified as acidic heteropolysaccharides by FT-IR and HPLC. Healthy male Kunming mice fed 20% fructose in drinking water for 8 consecutive weeks significantly displayed dyslipidemia, hepatic steatosis, oxidative stress and vascular endothelial dysfunction. However, continuous administration of IKTP at 200, 400 and 800 mg per kg bw in HF-fed mice could prevent the damage caused by HF-diets, especially at dosages of 400 and 800 mg per kg bw (p < 0...
July 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28617536/effects-of-mulberry-leaf-polysaccharide-on-oxidative-stress-in-pancreatic-%C3%AE-cells-of-type-2-diabetic-rats
#16
C-G Liu, Y-P Ma, X-J Zhang
OBJECTIVE: To explore and discuss the effects and mechanisms of mulberry leaf polysaccharide (MLP) on oxidative stress in pancreatic β-cells of type 2 diabetic rats. MATERIALS AND METHODS: The model of diabetic rats was established by inducing the Sprague-Dawley (SD) rats with high-sugar and high-fat diet for 6 weeks and then giving them streptozotocin (STZ) by single intraperitoneal injection. The mulberry leaf polysaccharide was administered via gavage daily for 8 weeks, and the tissue morphology was observed through electron microscopy...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28606375/circulating-lipoproteins-a-trojan-horse-guiding-squalenoylated-drugs-to-ldl-accumulating-cancer-cells
#17
Dunja Sobot, Simona Mura, Marie Rouquette, Branko Vukosavljevic, Fanny Cayre, Eric Buchy, Grégory Pieters, Sébastien Garcia-Argote, Maike Windbergs, Didier Desmaële, Patrick Couvreur
Selective delivery of anticancer drugs to rapidly growing cancer cells can be achieved by taking advantage of their high receptor-mediated uptake of low-density lipoproteins (LDLs). Indeed, we have recently discovered that nanoparticles made of the squalene derivative of the anticancer agent gemcitabine (SQGem) strongly interacted with the LDLs in the human blood. In the present study, we showed both in vitro and in vivo that such interaction led to the preferential accumulation of SQGem in cancer cells (MDA-MB-231) with high LDL receptor expression...
July 5, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28606074/modulatory-influence-of-acacia-hydaspica-r-parker-ethyl-acetate-extract-against-cisplatin-inveigled-hepatic-injury-and-dyslipidemia-in-rats
#18
Tayyaba Afsar, Suhail Razak, Ali Almajwal, Muhammad Rashid Khan
BACKGROUND: Cisplatin (CP) is recommended as a first-line chemotherapeutic agent for solid tumors, however its usage outcomes in severe adverse effects. Acacia hydaspica possesses various phytochemicals and pharmacological activities. The current study aimed to investigate the protective effect of A. hydaspica ethyl acetate extract (AHE) against CP induced aberrations in lipid profile and hepatotoxicity. METHODS: Rats were randomly separated into six groups (n = 6)...
June 12, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28603128/antihyperglycemic-and-antioxidant-effect-of-the-total-flavones-of-potentilla-kleiniana-wight-et-arn-in-streptozotocin-induced-diabetic-rats
#19
Shenghua Li, Juan Tan, Junying Zeng, Xianjin Wu Xianjin Wu, Jian Zhang
To investigate the antihyperglycemic and antioxidant activity of the total flavones of Potentilla kleiniana Wight et Arn. (TFP) in streptozotocin (STZ) induced diabetic rats. STZ-induced diabetic rats were treated with TFP weekly for 4 weeks at three doses (100 mg/kg, 200 mg/kg and 400 mg/kg). Blood glucose levels (BGL), body weight, insulin, total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), very low density lipoprotein (VLDL), low density lipoprotein (LDL), malondialdehyde (MDA), glutathione (GSH), super oxide dismutase (SOD) and catalase (CAT) levels of liver and pancreas were measured weekly for 4 weeks...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28579896/the-cytoprotective-effects-of-%C3%AE-17-fatty-acid-desaturase-on-injured-huvecs-and-its-underlying-mechanism
#20
Xiulan Zhang, Shixin Xia, Qiqi Xu, Jiandong Huang
Endothelium toxicity has been involved in early endothelial dysfunction to show the pathogenesis of multiple cardiovascular disease that shows atherosclerosis and its complications. Saturated free fatty acids are the main inducing factors of endothelial cell apoptosis and inflammatory cytokines. In humans, stearoyl-CoA desaturase 1 (SCD-1) is a restriction step to saturation to unsaturated fatty acid desaturation, which plays a beneficial role protecting endothelial cells against lipotoxicity. Δ-17 fatty acid desaturase (FAD) is a newly identified FAD which shares 55% identity at the amino acid level with SCD-1...
May 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
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