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Saleh Ayashi, Ahmad Reza Assareh, Mohammad Taha Jalali, Samaneh Olapour, Hamid Yaghooti
OBJECTIVE: Carvedilol is a nonselective third generation β-blocker that does not display the negative effects of traditional β-blockers. Regarding the antioxidant, anti-inflammatory and distinct metabolic properties of carvedilol which are similar to that of high-density lipoprotein (HDL) and paraoxonase 1 (PON1), the present study intends to investigate the effects of carvedilol treatment on malondialdehyde (MDA) and soluble lectin-like ox-low-density lipoprotein (LDL) receptor (sLOX-1) as markers of oxidative stress in association to lipid profiles, apolipoproteins (apo), and PON1 activity in hypertensive patients...
July 2016: Indian Journal of Pharmacology
Y Altuner Torun, U Ertural, A B Ergul, C Karakukcu, M A Akin
OBJECTIVE: Indirect bilirubin exerts an antioxidant effect when increased mildly. This study aimed to investigate whether increased bilirubin levels lead to an oxidant effect in newborns with hyperbilirubinemia requiring phototherapy. PATIENTS AND METHODS: The study included 30 term newborn infants aged 0-7 days with indirect hyperbilirubinemia requiring phototherapy and no comorbid disease as the study group. In addition, 30 term healthy newborn infants aged 0-7 days without indirect hyperbilirubinemia were employed as a control group...
October 11, 2016: Journal of Maternal-fetal & Neonatal Medicine
Vadim Z Lankin, Alla K Tikhaze
We have provided an overview, based on the literature and our data. In accordance with the theory of D. Harman free radical processes cause damages that can accumulate and contribute to aging of the organism. Atherosclerosis and diabetes are developing for a long time so they are manifested predominantly in old age. We found an increase in the level of free radical peroxidation products and decrease in the activity of antioxidant enzymes in the tissues of animals with experimental atherosclerosis. Similar changes were found by in the blood of patients with atherosclerosis and aortic autopsy material with atherosclerotic lesions...
September 26, 2016: Current Aging Science
Chizuko Maruyama, Rena Nakano, Mitsuha Shima, Asumi Mae, Yuri Shijo, Eri Nakamura, Yuuna Okabe, Sunmi Park, Noriko Kameyama, Satomi Hirai, Mamoru Nakanishi, Kagehiro Uchida, Hiroshi Nishiyama
AIM: We conducted a pilot study to clarify the effects of the Japan Diet nutritional education program on metabolic risk factors for atherosclerotic cardiovascular disease in middle-aged men who were brought up in the westernized dietary environment of modern Japan. METHODS: Thirty-three men, 30-49 years of age, attended a nutrition education class to learn food items and recommended volumes comprising the Japan Diet (more fish, soybeans and soy products, vegetables, seaweed, mushrooms and unrefined cereals, and less animal fat, meat and poultry with fat, sweets, desserts and snacks, and alcoholic drinks), and were encouraged to consume the Japan Diet for 6 weeks...
September 21, 2016: Journal of Atherosclerosis and Thrombosis
Jun Ye, Xuejun Xia, Wujun Dong, Huazhen Hao, Luhua Meng, Yanfang Yang, Renyun Wang, Yuanfeng Lyu, Yuling Liu
There is no effective clinical therapy for triple-negative breast cancers (TNBCs), which have high low-density lipoprotein (LDL) requirements and express relatively high levels of LDL receptors (LDLRs) on their membranes. In our previous study, a novel lipid emulsion based on a paclitaxel-cholesterol complex (PTX-CH Emul) was developed, which exhibited improved safety and efficacy for the treatment of TNBC. To date, however, the cellular uptake mechanism and intracellular trafficking of PTX-CH Emul have not been investigated...
2016: International Journal of Nanomedicine
Shuiping Yu, Xueling Zhou, Bingzong Hou, Bo Tang, Jian Li, Baimeng Zhang
The present study aimed to evaluate the protective effect of rosuvastatin treatment on the mechanism of oxidized low-density lipoprotein (Ox-LDL) in rats with liver fibrosis. In total, 72 male Sprague-Dawley rats were divided into 3 groups: 24 in the control group (A), 24 in the obstructive jaundice models group (B) and 24 in the rosuvastatin group (C). Each group was further divided into four subgroups for assessment at different time-points. The obstructive jaundice models were established and rosuvastatin was administered by gavage...
September 2016: Biomedical Reports
Hiroki Ikenaga, Satoshi Kurisu, Shingo Kono, Yoji Sumimoto, Noriaki Watanabe, Takashi Shimonaga, Tadanao Higaki, Toshitaka Iwasaki, Naoya Mitsuba, Ken Ishibashi, Yoshihiro Dohi, Yukihiro Fukuda, Yasuki Kihara
BACKGROUND: Malondialdehyde-modified low-density lipoprotein (MDA-LDL) is considered to play an essential role in plaque destabilization. We aimed to investigate the association between the tissue characteristics of culprit plaque assessed by integrated backscatter (IB)-intravascular ultrasound (IVUS) and the serum MDA-LDL levels in patients with stable coronary artery disease. METHODS AND RESULTS: The study group consisted of 179 patients undergoing IB-IVUS during elective percutaneous coronary intervention...
September 23, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
Emmanuel Omari-Siaw, Qilong Wang, Congyong Sun, Zengquan Gu, Yuan Zhu, Xia Cao, Caleb Kesse Firempong, Rita Agyare, Ximing Xu, Jiangnan Yu
An optimized perillaldehyde-loaded liposomal nanoformulation (PAH-LNF) was successfully applied to improve the pharmacological effect of perillaldehyde (PAH) in poloxamer 407-induced hyperlipidemia. Oral administration of PAH-LNF (240mg/kg per body weight) in rats significantly enhanced solubility and relative bioavailability (270.7%) compared to the free PAH with about 2.7-, 1.5-, 1.3-, 1.3- and 1.5-fold increase in AUC, T1/2, MRT, Cmax and Tmax, respectively. Tissue distribution study also revealed the accumulation of PAH in the liver, lungs, spleen, kidney, brain and heart in order of decreasing affinity...
August 24, 2016: International Journal of Pharmaceutics
I V Belik, A A Ivantsova, Z E Mamedova, A D Denisenko
The study included 79 patients with coronary artery disease, 25 individuals with preclinical atherosclerosis and 59 healthy controls. Key lipid parameters were examined in all the participants. Levels of antibodies (Abs) against (IgG and IgM) LDL modified by malondialdehyde (MDA), acetic anhydride and hypochlorite, were determined by the enzyme-linked immunosorbent assay (ELISA). Abs specificity was tested by competitive ELISA. Circulating immune complexes (CIC) were isolated by precipitation in polyethylene glycol...
May 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
Yuxiao Zou, Tenggen Hu, Ying Shi, Sentai Liao, Jun Liu, Lixia Mu, C-Y Oliver Chen
BACKGROUND: Silkworm pupae are good resources of edible oil that is especially rich in unsaturated fatty acids and considered an excellent dietary supplement for hyperlipidemia. RESULTS: Groups fed a high cholesterol diet (HCD) with SPO supplementation (1, 2, or 4 mL•kg(-1) •d(-1) ) orally had significantly lower levels of serum total cholesterol (TC) (P<0.05) and low-density lipoprotein cholesterol (LDL-C) (P<0.05) compared with the HCD group. In regard to antioxidant parameters, except for levels of glutathione peroxidase (GSH-Px) in the liver, 2 and 4 mL•kg(-1) •d(-1) of SPO supplementation leaded to higher total antioxidant capacity (T-AOC) (P<0...
August 25, 2016: Journal of the Science of Food and Agriculture
D Casamassima, M Palazzo, F Vizzarri, R Coppola, C Costagliola, C Corino, A Di Costanzo
Effects of dietary supplementation of Laurus nobilis on selected biochemical parameters and plasma oxidative status in growing rabbits, fed with and without enriched-fat diet, integrated with and without dried bay leaves meal, were investigated. In the test, 120 New Zealand white 35-day-old male rabbits were divided into four homogeneous groups of 30 animals each. A negative control group (CON) received a feed that met the animal nutrient requirement; a positive control group (CG) receiving a supplement of 2...
August 24, 2016: Journal of Animal Physiology and Animal Nutrition
He Tai, Ming-Yue Wang, Yue-Ping Zhao, Ling-Bing Li, Qian-Yan Dong, Xin-Guang Liu, Jin-Song Kuang
BACKGROUND: To observe the effect of alogliptin combined with metformin on pulmonary function in obese patients with type 2 diabetes inadequately controlled by metformin monotherapy (500 mg, bid po, for at least 3 months), and evaluate its efficacy and safety. METHODS: After a 2-week screening period, adult patients (aged 36-72 years) entered a 4-week run-in/stabilization period. Then, patients were randomly assigned to either the intervention group (n = 55) or the control group (n = 50) for 26 weeks...
August 2016: Medicine (Baltimore)
Qian Zhang, Xiaofang Sun, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Zhixin Wang, Cuijuan Qi, Tong Wang, Xiaojing Wang
It is now broadly accepted that the nutritional environment in early life is a key factor in susceptibility to metabolic diseases. In this study, we evaluated the effects of maternal chromium restriction in vivo on the modulation of lipid metabolism and the mechanisms involved in this process. Sixteen pregnant C57BL mice were randomly divided into two dietary treatments: a control (C) diet group and a low chromium (L) diet group. The diet treatment was maintained through gestation and lactation period. After weaning, some of the pups continued with either the control diet or low chromium diet (CC or LL), whereas other pups switched to another diet (CL or LC)...
2016: Nutrients
Shazia Anwer Bukhari, Kashaf Zafar, Muhammad Rajoka, Zubair İbrahim, Sadia Javed, Rafshan Sadiq
BACKGROUND/AIM: Biochemical, environmental, and genetic factors such as oxidative stress-induced DNA damage and homocysteine (Hcy) accumulation in the blood are involved in the development and progression of ovarian cancer. This study measured some biomarkers closely linked to the progression of ovarian cancer and also found their correlates. MATERIALS AND METHODS: Thirty patients were diagnosed with ovarian cancer using pelvic examination, transvaginal ultrasound, and cancer antibody (CA-125) measurement...
2016: Turkish Journal of Medical Sciences
Feifei Sun, Yangchun Cao, Chuanjiang Cai, Shengxiang Li, Chao Yu, Junhu Yao
This study investigated the effects of rumen-protected methionine (RPM) and rumen-protected choline (RPC) on energy balance, postpartum lactation performance, antioxidant capacity and immune response in transition dairy cows. Forty-eight multiparous transition cows were matched and divided into four groups: control, 15 g/d RPC, 15 g/d RPM or 15 g/d RPC + 15 g/d RPM. Diet samples were collected daily before feeding, and blood samples were collected weekly from the jugular vein before morning feeding from 21 days prepartum to 21 days postpartum...
2016: PloS One
T M Solomenchuk, V Vosukh, A Bedzay, V G Koval, I M Chepka, V V Trotsko
The article presents the results for the study of lipid correction capacity and safety of concomitant use of policosanol and rosuvastatin compared with rosuvastatin monotherapy in patients with stable coronary artery disease and moderate hepatic dysfunction. Fifty-seven subjects aged 37 to 72 years (mean age 54.4 years +/- 6.5 years) have been enrolled into the study with the following inclusion criteria: therapy with statins for more than 8 weeks, failure to achieve target LDL cholesterol levels and moderately elevated liver enzymes...
October 2015: Likars'ka Sprava
Saeed Samarghandian, Mohsen Azimi-Nezhad, Mahmoud M Shabestari, Farahzad Jabbari Azad, Tahereh Farkhondeh, Fereshteh Bafandeh
Cadmium (Cd) is an environmental toxic metal implicated in lipid abnormalities. The present study was designed to elucidate the possible association between chronic exposure to Cd concentration and alterations in plasma lipid, lipoprotein, and oxidative stress indices in rats. Sixteen male rats were assigned to 2 groups of 8 rats each (test and control). The Cd-exposed group obtained drinking water containing cadmium chloride (CdCl2) in the concentration of 2.0 mg Cd/L in drinking water for 3 months. At the end of the experimental period, blood samples were obtained to determine the changes of serum triglycerides (TG), total cholesterol (TC), highdensity lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), reduced glutathione (GSH), malondialdehyde (MDA) and also serum Cd contents...
September 2015: Interdisciplinary Toxicology
M Knaś, M Maciejczyk, I Daniszewska, A Klimiuk, J Matczuk, U Kołodziej, D Waszkiel, J R Ładny, M Żendzian-Piotrowska, A Zalewska
Objective. This study evaluated oxidative damage caused to the salivary glands in streptozotocin-induced diabetes (DM). Materials and Methods. Rats were divided into 4 groups: groups 1 and 2, control rats, and groups 3 and 4, DM rats. 8-Hydroxy-2'-deoxyguanosine (8-OHdG), protein carbonyl (PC), 4-hydroxynonenal protein adduct (4-HNE), oxidized and/or MDA-modified LDL-cholesterol (oxy-LDL/MDA), 8-isoprostanes (8-isoP), and oxidative stress index (OSI) were measured at 7 (groups 1 and 3) and 14 (groups 2 and 4) days of experiment...
2016: Journal of Diabetes Research
Huajie Zhao, Shangshang Li, Jianjun Zhang, Gen Che, Meng Zhou, Min Liu, Chen Zhang, Nuo Xu, Lin Lin, Yu Liu, Le Jia
Two polysaccharides, EIPS and AIPS were obtained by the hydrolysis of IPS from Termitomyces albuminosus, and their pharmacological effects on blood lipid profiles metabolism and oxidative stress were investigated. The results demonstrated that EIPS was superior to IPS and AIPS on reducing hepatic lipid levels and preventing oxidative stress by improving serum enzyme activities (ALT, AST, and ALP), serum lipid levels (TC, TG, HDL-C, LDL-C and VLDL-C), hepatic lipid levels (TC and TG), and antioxidant status (SOD, GSH-Px, CAT, T-AOC, MDA, and LPO)...
October 20, 2016: Carbohydrate Polymers
Pia Rantakari, Daniel A Patten, Joona Valtonen, Marika Karikoski, Heidi Gerke, Harriet Dawes, Juha Laurila, Steffen Ohlmeier, Kati Elima, Stefan G Hübscher, Chris J Weston, Sirpa Jalkanen, David H Adams, Marko Salmi, Shishir Shetty
Macrophages are key regulators of fibrosis development and resolution. Elucidating the mechanisms by which they mediate this process is crucial for establishing their therapeutic potential. Here, we use experimental models of liver fibrosis to show that deficiency of the scavenger receptor, stabilin-1, exacerbates fibrosis and delays resolution during the recovery phase. We detected a subset of stabilin-1(+) macrophages that were induced at sites of cellular injury close to the hepatic scar in mouse models of liver fibrosis and in human liver disease...
August 16, 2016: Proceedings of the National Academy of Sciences of the United States of America
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