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https://www.readbyqxmd.com/read/29625223/antioxidant-and-hepatoprotective-effects-of-intracellular-mycelium-polysaccharides-from-pleurotus-geesteranus-against-alcoholic-liver-diseases
#1
Xinling Song, Qiang Shen, Min Liu, Chen Zhang, Lan Zhang, Zhenzhen Ren, Wenshuai Wang, Yuhan Dong, Xiuxiu Wang, Jianjun Zhang, Le Jia
In the present study, we investigated the antioxidant and hepatoprotective effects of intracellular mycelium polysaccharides from Pleurotus geesteranus (IMPP) to address acute alcoholic liver diseases (ALD). Animal studies have demonstrated that the hepatic parameters of CYP2E1, MPO, TC, ALT, AST and ALP, HDLC, LDL-C and VLDL-C were improved; the inflammatory factor levels, including TNF-α, IL-1β and IL-6, were decreased; the hepatic ADH and ALDH activities were inhibited; the activities of the antioxidant enzymes SOD, GSH-Px, CAT and T-AOC were enhanced; and the MDA and LPO contents were reduced by IMPP treatment...
April 3, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29576521/relationship-between-serum-levels-of-oxidative-stress-and-metabolic-syndrome-components
#2
Maryam Abbasian, Mehri Delvarianzadeh, Hossein Ebrahimi, Farideh Khosravi, Pirasteh Nourozi
AIMS: This study aimed to investigate the relationship between the total antioxidant capacity (TAC) and Malondialdehyde (MDA) with number of metabolic syndrome (Mets) components on the personnel working in Shahroud University of Medical Sciences. METHODS: This cross-sectional study was conducted on 167 personnel aged 30-60 years old. ATP III criteria were used to diagnose patients with MetS. Oxidative stress indicators were measured. The data was analyzed via one-way ANOVA, and Pearson and Spearman correlation coefficients...
March 16, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29564091/the-effect-of-opuntia-ficus-indica-juice-supplementation-on-oxidative-stress-cardiovascular-parameters-and-biochemical-markers-following-yo-yo-intermittent-recovery-test
#3
Aloui Khouloud, Salma Abedelmalek, Hamdi Chtourou, Nizar Souissi
The aim of the study was to investigate the effect of a flavonoid-rich fresh fruit juice on cardiovascular, oxidative stress, and biochemical parameters during the yo-yo intermittent recovery test (YYIRT). Twenty-two healthy males subjects participated in this study divided into two groups: An experimental group (EG: n  = 11) who consumed the antioxidant supplement and a control group (CG: n  = 11). All participants performed two test sessions at 07:00 hr before and after 2 weeks of supplementation with Opuntia ficus-indica juice...
March 2018: Food Science & Nutrition
https://www.readbyqxmd.com/read/29558323/effects-of-chicory-leaf-extract-on-serum-oxidative-stress-markers-lipid-profile-and-periodontal-status-in-patients-with-chronic-periodontitis
#4
Hossein Babaei, Fahimeh Forouzandeh, Leila Maghsoumi-Norouzabad, Hojat Allah Yousefimanesh, Maryam Ravanbakhsh, Ahmad Zare Javid
AIM: The aim of present study was to evaluate the effects of chicory leaf extract on serum oxidative stress markers, lipid profile, and periodontal status in patients with chronic periodontitis. METHODS: In this double-blind, randomized controlled clinical trial 40 patients with chronic periodontitis were allocated to intervention and control groups. The intervention group received a 1-gram chicory leaf methanolic extract capsule twice daily for 8 weeks. In the control group, participants received a placebo capsule (containing 1 gram wheat flour) twice daily for 8 weeks...
March 20, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29528768/effect-of-low-energy-dense-diet-rich-in-multiple-functional-foods-on-weight-loss-maintenance-inflammation-and-cardiovascular-risk-factors-a-randomized-controlled-trial
#5
Vajihe Izadi, Fahimeh Haghighatdoost, Parisa Moosavian, Leila Azadbakht
BACKGROUND: There are no investigations regarding the effects of consuming low-energy-dense diets rich in multiple functional foods on weight-loss maintenance, inflammatory markers, and cardiovascular disease (CVD) risk factors simultaneously. METHOD: This randomized controlled trial design was conducted on 90 men and women who were under a previous weight loss diet. Three months of intervention with recruitment at Allzahra Hospital, Isfahan, Iran, was done. Intervention was conducted following achieving 7-11 kg weight loss...
March 12, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29527628/efficiencies-of-low-level-laser-therapy-lllt-and-gabapentin-in-the-management-of-peripheral-neuropathy-diabetic-neuropathy
#6
Khaled G Abdel-Wahhab, Eitedal M Daoud, Aliaa El Gendy, Hagar H Mourad, Fathia A Mannaa, Maha M Saber
Diabetic neuropathy (DN) is the highly occurred complication of diabetes mellitus; it has been defined as an event of peripheral nerve dysfunction characterized by pain, allodynia, hyperalgesia, and paraesthesia. The current study was conducted to evaluate the efficacy of low-level laser therapy (LLLT) in the management of neuropathy in diabetic rats. The used animals were divided into the following groups: negative control, streptozotocin-induced diabetic rats, and diabetic rats with peripheral neuropathy (DNP) and DNP treated with gabapentin or with LLLT...
March 12, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29446047/epigallocatechin-gallate-suppresses-hepatic-cholesterol-synthesis-by-targeting-srebp-2-through-sirt1-foxo1-signaling-pathway
#7
Yongnan Li, Shuodong Wu
This study aims to explore the effect of epigallocatechin gallate (EGCG) on blood lipids, liver lipids, and cholesterol synthesis in hyperlipidemic rats. SREBP-2 transgenic rats were used to investigate the transcriptional level of SREBP-2 regulated by SIRT-1/FOXO1 and the molecular mechanism of rate-limiting enzyme HMGCR that affects cholesterol synthesis. Rat models of hyperlipidemia were established and administered EGCG. Cholesterol synthesis was observed. Enzyme linked immunosorbent assay was used to determine serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), free fatty acid (FFA), superoxide dismutase (SOD), malondialdehyde (MDA), and T-AOC contents...
February 14, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29444683/potential-effects-of-the-combination-of-nicotinamide-vitamin-b2-and-vitamin-c-on-oxidative-mediated-hepatotoxicity-induced-by-thioacetamide
#8
Samir A E Bashandy, Hossam Ebaid, Sherif A Abdelmottaleb Moussa, Ibrahim M Alhazza, Iftekhar Hassan, Abdulaziz Alaamer, Jameel Al Tamimi
BACKGROUND: The liver disease is one of the most important traditional public health problems in Egypt. Oxidative stress is attributed to such pathological condition that further contributes to the initiation and progression of liver injury. In the present study, we have investigated if the strong antioxidant power of Nicotinamide (NA), Vitamin B2 (VB2), and Vitamin C (VC) can ameliorate TAA-induced oxidative stress-mediated liver injury in the rats. METHODS: Thirty-six albino rats were divided into six groups: Control group; TAA group (IP injection with TAA at a dosage of 200 mg/Kg three times a week for two months); TAA + NA group (rats administered with NA at a dosage of 200 mg/kg daily besides TAA as in the control); TAA + VB2 group (rats administered with vitamin B2 at a dosage of 30 mg/kg daily besides injection with TAA); TAA + VC group (rats administered with vitamin C at a dosage of 200 mg/kg daily along with injection of TAA)...
February 14, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29438753/antidiabetic-activities-of-polysaccharides-from-anoectochilus-roxburghii-and-anoectochilus-formosanus-in-stz-induced-diabetic-mice
#9
Tingting Tang, Xiaoyu Duan, Yu Ke, Lan Zhang, Yingbin Shen, Bin Hu, Aiping Liu, Hong Chen, Cheng Li, Wenjuan Wu, Li Shen, Yuntao Liu
Six polysaccharides were extracted from different parts (whole plants, roots and leaves) of Anoectochilus roxburghii and Anoectochilus formosanus (ARPs, ARPs-1, ARPs-2, AFPs, AFPs-1 and AFPs-2). Their primary characteristics were identified and their antidiabetic activities were evaluated in STZ-induced diabetic mice. Root polysaccharides (ARPs-1and AFPs-1) and leaf polysaccharides (ARPs-2 and AFPs-2) were distinct from each other in terms of the Mws, monosaccharide compositions and functional groups. Notably, the primary structures of ARPs and AFPs were similar to those of ARPs-1and AFPs-1, respectively...
February 10, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29384323/regular-egg-consumption-at-breakfast-by-japanese-woman-university-students-improves-daily-nutrient-intakes-open-labeled-observations
#10
Chie Taguchi, Yoshimi Kishimoto, Norie Suzuki-Sugihara, Emi Saita, Mika Usuda, Wei Wang, Yasunobu Masuda, Kazuo Kondo
BACKGROUND AND OBJECTIVES: Eggs, an important source of high-quality protein, contain a variety of key nutrients and antioxidants. Here we conducted an intervention study to evaluate whether the additional consumption of one egg per day would affect the daily nutritional intakes and blood antioxidant status in Japanese woman university students. METHODS AND STUDY DESIGN: For 4 weeks, the 14 subjects were provided a nutritious breakfast including one boiled egg, and they were asked to keep a daily dietary record...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29370236/ethyl-pyruvate-inhibits-oxidation-of-ldl-in-vitro-and-attenuates-oxldl-toxicity-in-ea-hy926-cells
#11
Christine Rossmann, Christoph Nusshold, Margret Paar, Gerhard Ledinski, Erwin Tafeit, Martin Koestenberger, Eva Maria Bernhart, Wolfgang Sattler, Gerhard Cvirn, Seth Hallström
BACKGROUND: Ethyl pyruvate (EP) exerts anti-inflammatory and anti-oxidative properties. The aim of our study was to investigate whether EP is capable of inhibiting the oxidation of LDL, a crucial step in atherogenesis. Additionally, we examined whether EP attenuates the cytotoxic effects of highly oxidized LDL in the human vascular endothelial cell line EA.hy926. METHODS: Native LDL (nLDL) was oxidized using Cu2+ ions in the presence of increasing amounts of EP...
2018: PloS One
https://www.readbyqxmd.com/read/29365615/circulating-mda-ldl-after-endovascular-therapy-evt-as-novel-prognostic-marker-in-peripheral-artery-disease-pad-patients
#12
Takaaki Takamura, Minako Oda, Makoto Watanabe, Ryuhei Saito, Taketsugu Tsuchiya, Hironobu Akao, Yasuyuki Kawai, Michihiko Kitayama, Kouji Kajinami
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29353699/near-infrared-heat-lamp-therapeutic-effect-on-paraoxonase-1-and-myeloperoxidase-as-potential-biomarkers-of-redox-state-changes-induced-by-%C3%AE-irradiation-in-albino-rats
#13
N Abdel-Magied, A G Ahmed, S M Shedid
Infrared radiation has a potential therapeutic effect in some diseases. The aim of this study was to estimate the therapeutic role of near infrared heat lamp (NIRHL) on the variations of the activity of paraoxonase 1 (PON1) and myeloperoxidase (MPO), in relation to lipid disorders, associated with oxidative stress in rats gamma-irradiated. In addition, study the effect of the duration of NIRHL treatment. Animals were divided into six groups. The results revealed that irradiated rats treated with NIRHL 20 min/once/day showed positive modulation of PON1 and MPO linked to significant improvement of lipid disorders evidenced by lower triglycerides, low density lipoprotein cholesterol (LDL-C), oxidized low density lipoprotein cholesterol (oxLDL-C) and higher density lipoprotein cholesterol (HDL-C) as well as significant amelioration of redox state, manifested by markedly increase of glutathione (GSH) content, total antioxidant capacity (TAC) associated with a noticeable decrease of pro-inflammatory cytokines...
January 16, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29353208/natural-products-berberine-and-curcumin-exhibited-better-ameliorative-effects-on-rats-with-non-alcohol-fatty-liver-disease-than-lovastatin
#14
Wu-Wen Feng, Shuang-Yu Kuang, Can Tu, Zhi-Jie Ma, Jing-Yao Pang, Yan-Hui Wang, Qing-Ce Zang, Ta-Si Liu, Yan-Ling Zhao, Xiao-He Xiao, Jia-Bo Wang
Studies have shown that satins and herbal products have potential to treat non-alcohol fatty liver disease (NAFLD) in clinic. However, no study has compared their effects, and their mechanisms remain unresolved. Here, we choose lovastatin and two herbal products including berberine and curcumin to compare their effects in treating NAFLD. NAFLD model was established by high fat food, and rats were administrated with lovastatin, berberine, curcumin, berberine + curcumin at the dosage of 100, 100, 100, 50 + 50 mg/kg bw, respectively...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29352865/antihyperlipidemic-and-hepatoprotective-activities-of-polysaccharide-fraction-from-cyclocarya-paliurus-in-high-fat-emulsion-induced-hyperlipidaemic-mice
#15
Zhanwei Yang, Jin Wang, Jingen Li, Lei Xiong, Hui Chen, Xin Liu, Ning Wang, Kehui Ouyang, Wenjun Wang
The objective of this study was to analyse the structure of CPP-2, and to observe the pharmacological effects of CPP-2 on lipid metabolism and oxidative stress. CPP-2, eluted as two main fractions comprised of two polysaccharides with Mw of 307 and 3.7kDa, was mainly consisted of rhamnose, mannose, glucose and galactose in a molar ratio of 1.00:0.78:3.22:0.45. The results showed that treatment with CPP-2 could improve blood lipid levels (TC, TG, HDL-C and LDL-C), liver lipid levels (TC and TG) and antioxidant status (SOD, T-AOC, GSH-PX, MDA and LPO)...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29331380/eicosapentaenoic-acid-inhibits-oxidation-of-high-density-lipoprotein-particles-in-a-manner-distinct-from-docosahexaenoic-acid
#16
Samuel C R Sherratt, R Preston Mason
The omega-3 fatty acid eicosapentaenoic acid (EPA) reduces oxidation of ApoB-containing particles in vitro and in patients with hypertriglyceridemia. EPA may produce these effects through a potent antioxidant mechanism, which may facilitate LDL clearance and slow plaque progression. We hypothesize that EPA antioxidant effects may extend to ApoA-containing particles like HDL, potentially preserving certain atheroprotective functions. HDL was isolated from human plasma and incubated at 37 °C in the absence (vehicle) or presence of EPA and/or DHA; 5...
February 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29324056/cardiopulmonary-effects-induced-by-occupational-exposure-to-titanium-dioxide-nanoparticles
#17
Lin Zhao, Yifang Zhu, Zhangjian Chen, Huadong Xu, Jingwen Zhou, Shichuan Tang, Zhizhen Xu, Fanling Kong, Xinwei Li, Yifei Zhang, Xianzuo Li, Ji Zhang, Guang Jia
Although some toxicological studies have reported that exposure to titanium dioxide nanoparticles (nano-TiO2 ) may elicit adverse cardiopulmonary effects, related data collected from human are currently limited. The purpose of this study is to explore cardiopulmonary effects among workers who were exposed to nano-TiO2 and to identify biomarkers associated with exposure. A cross-sectional study was conducted in a nano-TiO2 manufacturing plant in eastern China. Exposure assessment and characterization of TiO2 particles were performed in a packaging workshop...
March 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29299589/hypolipidemic-effect-and-protection-ability-of-liver-kidney-functions-of-melanin-from-lachnum-ym226-in-high-fat-diet-fed-mice
#18
Fang Shi, Jinglei Li, Liuqing Yang, Guohua Hou, Ming Ye
In the present study, we investigated the hypolipidemic properties of melanin from Lachnum YM226 (LM) in high-fat diet induced hyperlipidemic mice. After the hyperlipidemic model was established, mice were randomly divided into six groups, as follows: normal control group (NC), hyperlipidemic control group (HC), positive control group (7 mg kg-1 d-1 simvastatin) (PC) and LM groups (50, 100 and 200 mg kg-1 d-1 denoted as LM-50, LM-100 and LM-200, respectively). Subsequently, the body weight, organ indices, lipid metabolism, antioxidant properties and liver-kidney functions of the mice were examined...
February 21, 2018: Food & Function
https://www.readbyqxmd.com/read/29273831/synergism-between-apolipoprotein-e-%C3%A6-4-allele-and-paraoxonase-pon1-55-m-allele-is-associated-with-risk-of-systemic-lupus-erythematosus
#19
Maryam Tanhapour, Ali Miri, Asad Vaisi-Raygani, Fariborz Bahrehmand, Amir Kiani, Zohreh Rahimi, Tayebeh Pourmotabbed, Ebrahim Shakiba
Evidences indicate that abnormal lipid metabolism and lipid peroxidation can affect the progression of complications in systemic lupus erythematosus (SLE) patients. Apolipoprotein E (ApoE) and paraoxonase-1 (PON1) play important role in lipid metabolism and protection of lipid peroxidation. The polymorphisms of ApoE and paraoxonase (PON1) L55M (Met < Leu) allele genes lead to disorders in lipid metabolism and are related to atherosclerosis. This study is the first investigation to examine the possible association between ApoE and PON1-L55M polymorphisms and correlation with serum arylesterase (ARE) activities of PON, levels of malondialdehyde (MDA), neopterin, and lipid lipoprotein in SLE patients from Iranian western population...
December 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29250300/cultivation-and-immortalization-of-human-b-cells-producing-a-human-monoclonal-igm-antibody-binding-to-mda-ldl-further-evidence-for-formation-of-atherogenic-mda-ldl-adducts-in-humans-in-vivo
#20
Franz Tatzber, Edith Pursch, Ulrike Resch, Roswitha Pfragner, Sandra Holasek, Meinrad Lindschinger, Gerhard Cvirn, Willibald Wonisch
Oxidatively modified low-density lipoprotein (oLDL) is firmly believed to play an important role in the initiation and development of atherosclerosis, and malonic dialdehyde (MDA) is one of the major lipid peroxidation breakdown products involved in this process. In recent decades, antibodies against MDA-LDL have been detected in human and animal sera. In our study, human B-cells from the peripheral blood of a healthy female donor were fused with the SP2/0 mouse myeloma cell line. Antibody-producing hybridomas were detected by MDA-LDL-IgG/IgM enzyme-linked immunosorbent assays (ELISA) and Cu++ -oxidized LDL IgG/IgM (oLAb) ELISA...
2017: Oxidative Medicine and Cellular Longevity
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