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https://www.readbyqxmd.com/read/28321031/role-of-ketotifen-on-metabolic-profiles-inflammation-and-oxidative-stress-in-diabetic-rats
#1
Zimiao Chen, Hongwei Sun, Jian Wang, Liansong Ni, Xuejiang Gu, Shengjie Ge, Qiong Chen, Liangshan Mu, Xingbo Cheng
We aim to explore effects of Ketotifen on metabolic profiles, inflammation and oxidative stress. Sprague Dawley (SD) male rats were randomly divided into normal control group (NC) and experimental groups, and experimental group rats were fed with high-sugar and fat diet for 6 weeks. Then, experimental group rats were divided into diabetes group (DM) and ketotifen treatment group (KT). KT group was given ketotifen via Intragastric for 8 weeks with the dosage of 0.09 mg/kg•d. Fasting plasma glucose (FPG) was measured using glucose oxidase-phenol amino phenazone method...
March 17, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28319871/autoantibodies-and-immune-complexes-to-oxidation-specific-epitopes-and-progression-of-aortic-stenosis-results-from-the-astronomer-trial
#2
Romain Capoulade, Kwan L Chan, Patrick Mathieu, Yohan Bossé, Jean G Dumesnil, James W Tam, Koon K Teo, Xiaohong Yang, Joseph L Witztum, Benoit J Arsenault, Jean-Pierre Després, Philippe Pibarot, Sotirios Tsimikas
BACKGROUND AND AIMS: Elevated levels of lipoprotein(a) [Lp(a)] and oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) predict the progression of pre-existing mild-to-moderate calcific aortic valve stenosis (CAVS). Whether indirect markers of oxidation-specific epitopes (OSE) are also predictive is not known. The association between IgG and IgM autoantibodies and malondialdehyde-modified low density lipoprotein (MDA-LDL) and IgG and IgM apolipoprotein B immune complexes (apoB-IC), and the hemodynamic progression rate of CAVS was determined in the ASTRONOMER (Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin, NCT00800800) trial...
March 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28301565/parallel-comparison-of-risk-factors-between-progression-of-organic-stenosis-in-the-coronary-arteries-and-onset-of-acute-coronary-syndrome-by-covariance-structure-analysis
#3
Kazuo Ogawa, Kosuke Minai, Makoto Kawai, Toshikazu Tanaka, Tomohisa Nagoshi, Takayuki Ogawa, Michihiro Yoshimura
BACKGROUND: It is widely accepted that progression of organic stenosis in the coronary arteries and onset of acute coronary syndrome (ACS) are similar in the development of atherosclerosis. However, the extent of the association of each risk factor with the respective pathological conditions has not been fully elucidated. OBJECTIVES: We investigated the differences in risk factors between these conditions using a statistical procedure. METHODS: The study population consisted of 1,029 patients with ischemic heart disease (IHD)...
2017: PloS One
https://www.readbyqxmd.com/read/28299944/streptococcus-thermophilus-fermented-milk-reduces-serum-mda-ldl-and-blood-pressure-in-healthy-and-mildly-hypercholesterolaemic-adults
#4
M Ito, S Kusuhara, W Yokoi, T Sato, H Ishiki, S Miida, A Matsui, K Nakamori, C Nonaka, K Miyazaki
Low-density lipoprotein (LDL)-cholesterol, malondialdehyde-modified low-density lipoprotein (MDA-LDL), MDA-LDL/LDL-cholesterol in serum, and blood pressure are considered useful risk markers of cardiovascular diseases. This study aimed to examine whether a fermented milk containing Streptococcus thermophilus YIT 2001 (ST), which has high anti-oxidative activity, would benefit healthy and mildly hyper-LDL-cholesterolaemic adults via a randomised, double-blind, placebo-controlled trial. ST-fermented milk or non-fermented placebo milk (PC) was consumed once a day for 12 weeks by 29 and 30 subjects, respectively, with average serum LDL-cholesterol levels of about 140 mg/dl...
March 16, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28296591/hypolipidemic-and-antioxidant-effects-of-malus-toringoides-rehd-hughes-leaves-in-high-fat-diet-induced-hyperlipidemic-rats
#5
Shan Huang, Haifeng Liu, Ning Meng, Bin Li, Jule Wang
Malus toringoides (Rehd.) Hughes (MT) leaves are traditionally used as a medicine for treating or preventing cardiovascular disease in Tibet. In addition to the effect of this medicinal plant on thrombosis, we tested its effect on dyslipidemia in a hypolipidemic rat model. A total of 60 healthy Sprague-Dawley rats were randomly divided into six groups, as follows: normal control, model control, simvastatin groups, and MT low-, medium-, and high-dose groups. The normal controls were fed with a normal diet, whereas all other groups were fed with a high-fat diet...
March 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28288411/vitexin-alleviates-ox-ldl-mediated-endothelial-injury-by-inducing-autophagy-via-ampk-signaling-activation
#6
Shaoli Zhang, Changlei Guo, Zhigang Chen, Peiyong Zhang, Jianhua Li, Yan Li
Endothelial cell injury plays a crucial role in the development and pathogenesis of cardiovascular disease. Vitexin is a natural flavonoid characterized by anti-oxidative and anti-inflammatory properties. The purpose of this study was to investigate the effects of vitexin on ox-LDL-induced endothelial dysfunction and to explore the underlying molecular mechanisms. In the present study, vitexin was found to play a protective role against ox-LDL-induced endothelial injury. Vitexin significantly promoted cell viability and inhibited apoptosis in ox-LDL-treated HUVECs...
March 10, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28264426/the-combination-of-blueberry-juice-and-probiotics-ameliorate-non-alcoholic-steatohepatitis-nash-by-affecting-srebp-1c-pnpla-3-pathway-via-ppar-%C3%AE
#7
Tingting Ren, Juanjuan Zhu, Lili Zhu, Mingliang Cheng
Nonalcoholic steatohepatitis (NASH) is liver inflammation and a major threat to public health. Several pharmaceutical agents have been used for NASH therapy but their high-rate side effects limit the use. Blueberry juice and probiotics (BP) have anti-inflammation and antibacterial properties, and may be potential candidates for NASH therapy. To understand the molecular mechanism, Sprague Dawley rats were used to create NASH models and received different treatments. Liver tissues were examined using HE (hematoxylin and eosin) and ORO (Oil Red O) stain, and serum biochemical indices were measured...
February 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28250654/insulin-plant-costus-pictus-extract-restores-thyroid-hormone-levels-in-experimental-hypothyroidism
#8
S Ashwini, Zachariah Bobby, M G Sridhar, C C Cleetus
BACKGROUND: The aim of the present study was to investigate the preventive effect of Costus pictus leaf extract in experimental hypothyroidism. MATERIALS AND METHODS: Forty male Wistar rats were randomly divided into four groups with ten rats in each group: Control (C), hypothyroid (H), control+extract (C+E), and hypothyroid+extract (H+E). Rats in C group did not receive any intervention throughout the experimental period. The rats in the C+E and H+E groups received pretreatment with C...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28239698/beneficial-effects-of-apple-peel-polyphenols-on-vascular-endothelial-dysfunction-and-liver-injury-in-high-choline-fed-mice
#9
Mengfan Jia, Daoyuan Ren, Yan Nie, Xingbin Yang
This study was designed to investigate the preventive effects of Red Fuji apple peel polyphenolic extract (APP) on vascular endothelial dysfunction and liver injury in mice fed a high choline diet. The mice were fed 3% dietary choline in drinking water for 8 weeks and displayed vascular dysfunction and liver damage (p < 0.01). The administration of APP at 600 and 900 mg per kg bw significantly elevated serum NO, HDL and 6-Keto-PGF1a levels and lowered serum TC, TG, LDL, ET-1 and TXB2 levels in the HC-fed mice...
February 27, 2017: Food & Function
https://www.readbyqxmd.com/read/28228702/catechin-treatment-ameliorates-diabetes-and-its-complications-in-streptozotocin-induced-diabetic-rats
#10
Saeed Samarghandian, Mohsen Azimi-Nezhad, Tahereh Farkhondeh
CONTEXT: Diabetes mellitus causes atherosclerosis and lipid abnormalities. Hypolipidemic and antioxidative properties of catechin (CTN) have been reported in several studies. OBJECTIVE: This study assesses the possible protective effects of CTN against oxidative damage in the diabetic rats. MATERIALS AND METHODS: The rats were divided into the control, untreated diabetic, and 3 CTN-treated diabetic groups (20, 40, and 80 mg/kg/d, intraperitoneal)...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28225475/stretching-exercises-improve-vascular-endothelial-dysfunction-through-attenuation-of-oxidative-stress-in-chronic-heart-failure-patients-with-an-implantable-cardioverter-defibrillator
#11
Michitaka Kato, Takashi Masuda, Michio Ogano, Kazuki Hotta, Hisato Takagi, Shinya Tanaka, Yumi Kamada, Ayako Akiyama, Daisuke Kamekawa, Ryosuke Shimizu, Minoru Tabata, Jun Tanabe, Takuya Umemoto
PURPOSE: Endurance training improves oxidative stress and vascular endothelial dysfunction in patients with chronic heart failure (CHF). However, patients with CHF and an implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy-defibrillator (CRT-D) often avoid endurance training for fear of ICD shock. Recent studies have reported that stretching exercises enhance antioxidant activity and improve vascular responses. Therefore, we aimed to assess the effects of 4 weeks of stretching exercises on oxidative stress and vascular endothelial function in patients with CHF with an ICD or CRT-D...
March 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28207162/plasma-oxidative-stress-and-inflammatory-biomarkers-are-associated-with-the-sizes-of-the-left-atrium-and-pulmonary-vein-in-atrial-fibrillation-patients
#12
Jin-Yi Li, Yan He, Hong-Hong Ke, Yu Jin, Zhi-Yuan Jiang, Guo-Qiang Zhong
BACKGROUND: Oxidative stress and inflammatory processes are responsible for the pathogenesis of AF, but their relationship with the sizes of the LA and PVs in AF patients remains unclear. HYPOTHESIS: Oxidative stress and inflammatory processes are associated with the sizes of the LA and PVs in AF patients. METHODS: 82 AF patients were compared to 30 control patients by using a case-control study design. Oxidative stress, inflammatory biomarkers and the sizes of the LA and PVs were detected...
February 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28193083/comparison-of-pure-palm-olein-oil-hydrogenated-oil-containing-palm-and-canola-on-serum-lipids-and-lipid-oxidation-rate-in-rats-fed-with-these-oils
#13
COMPARATIVE STUDY
Seyed-Asadollah Amini, Keihan Ghatreh-Samani, Arash Habibi-Kohi, Laleh Jafari
BACKGROUND: Due to increased consumption of canola oil and hydrogenated oil containing palm and palm olein, and their possible effects on serum lipoproteins, the present study was conducted to determine the effects of these oils on lipids and lipid oxidation level. METHODS: In this experimental study, 88 Wistar rats were randomly assigned to four groups. Control group (A) was on a normal diet. Groups B, C, and D, in addition to normal diet, were fed with hydrogenated oil-contained palm oil, pure palm olein oil, and canola oil, respectively for 4 weeks...
February 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28177669/beta-sitosterol-up-regulated-paraoxonase-1-via-peroxisome-proliferator-activated-receptor-%C3%AE-in-irradiated-rats
#14
Enas Moustafa, Noura Magdy Thabet
This study was designed to evaluate the effect of Beta-sitosterol (BS) on the of peroxisome proliferator-activated receptor gamma (PPAR-γ) gene expression role in the activity of PON-1 enzyme in oxidative stress status of irradiated rats. Animals were exposed to whole body γ-radiation single dose 6Gy and received BS dose (40 mg•(kg body mass) -1•day -1, orally). In liver tissue, gene expression of PPAR-γ ligand was determined. Oxidative stress marker (malonyldialdehyde, MDA) and antioxidant enzymes activities (Superoxide dismutase; SOD Catalase; CAT, PON-1 and arylesterase; ARE) were assayed in serum and liver tissue...
January 24, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28173817/pigment-epithelium-derived-factor-alleviates-endothelial-injury-by-inhibiting-wnt-%C3%AE-catenin-pathway
#15
Shouyuan Ma, Shutong Yao, Hua Tian, Peng Jiao, Nana Yang, Ping Zhu, Shucun Qin
BACKGROUND: Oxidized low-density lipoprotein (ox-LDL) can induce endothelial injury and plays a vital role in the procession and development of atherosclerosis. Little is known regarding whether Wnt/β-catenin pathway is involved in ox-LDL-induced endothelial injury or whether it further promotes atherosclerosis via increased oxidative stress. This study aimed to investigate the role of Wnt/β-catenin pathway in ox-LDL-induced vascular endothelial injury and determine whether pigment epithelium-derived factor (PEDF) could alleviate ox-LDL-induced endothelial injury by inhibiting Wnt/β-catenin pathway...
February 7, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28169366/phytosterol-esters-attenuate-hepatic-steatosis-in-rats-with-non-alcoholic-fatty-liver-disease-rats-fed-a-high-fat-diet
#16
Lihua Song, Dan Qu, Qing Zhang, Jing Jiang, Haiyue Zhou, Rui Jiang, Yating Li, Yao Zhang, Hongli Yan
Given the adverse effects of drugs used for NAFLD treatment, identifying novel and effective natural compound to prevent NAFLD is urgently needed. In the present study, the effects of phytosterol esters (PSEs) on NAFLD were explored. Adult SD rats were randomized into five groups: normal chow diet (NC), high-fat diet (HF), low-, medium- and high-dose PSE treatment plus high-fat diet groups (PSEL, PSEM, and PSEH). Our results showed that the levels of LDL-C in the PSEL group and hepatic TG, TC, and FFA in the three PSEs groups were significantly decreased...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28167469/relationship-of-oxidative-stress-with-elevated-level-of-dna-damage-and-homocysteine-in-cardiovascular-disease-patients
#17
Muhammad Qasim, Shazia Anwer Bukhari, Madiha Javeed Ghani, Muhammad Shareef Masoud, Tayyabah Huma, Muhammad Arshad, Asma Haque, Zubair Ibrahim, Sadia Javed, Muhammad Ibrahim Rajoka
Amounts of DNA damage and homocysteine (Hcy) in heart patients blood may have strong function in the causation of cardiovascular disease (CVD). The main objective of this work was to know experimentally the role of total oxidants (produced by Reactive Oxygen species (ROS), clinical biochemical indices, their oxidized products and total antioxidant status (TAS) among such patients to find the association of homocysteine, total oxidation status (TOS) and oxidative DNA damage with other clinical parameters in sixty positive CVD patients compared with those of 60 normal subjects...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28164576/oxidized-low-density-lipoprotein-ox-ldl-to-ldl-ratio-ox-ldl-ldl-and-ox-ldl-to-high-density-lipoprotein-ratio-ox-ldl-hdl
#18
Mahtab Motamed, Arash A Nargesi, Behnam Heidari, Hossein Mirmiranpour, Alireza Esteghamati, Manouchehr Nakhjavani
BACKGROUND: Oxidized low-density lipoprotein (ox-LDL) plays a principal role in diabetes complications, though ox-LDL concentrations and its functions are dependents of other oxidative and anti-oxidative particles. The oxLDL to low-density lipoprotein ratio (ox-LDL/LDL) and ox-LDL to high-density lipoprotein ratio (ox-LDL/HDL) as new lipid biomarkers may serve as a good estimation of oxidation and anti-oxidation in type 2 diabetes mellitus. The aim of this study was first to examine ox-LDL/LDL and ox-LDL/HDL levels in patients with type 2 diabetes mellitus compared to a control group and evaluate their diagnostic accuracies, and, second, to investigate the correlation of these two ratios with triglyceride and HDL levels...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28154312/effects-of-m%C3%AE-cd-on-lipoxygenase-induced-ldl-oxidation
#19
Meiying Ao, Yong Chen
Beta-cyclodextrin (β-CD) has been applied as drug/food carriers or potential drugs for treating some diseases. Most recently, some evidence indicated that methyl-β-cyclodextrin (MβCD) and 2-hydroxypropyl-β-cyclodextrin (2-HPβCD), two major derivatives of β-CD, may inhibit atherogenesis, implying that cyclodextrins also can be potential drugs for treating atherosclerosis. It is well known that modification (e.g. oxidation) of low-density lipoprotein (LDL) is one of the most critical steps of atherogenesis...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28150588/inhibition-of-kupffer-cell-functions-modulates-arsenic-intoxication-in-wistar-rats
#20
Oluyomi S Adeyemi, Ekong Meyakno, Musbau A Akanji
Study determined the influence of the inhibition of Kupffer cell functions by GdCl3 in arsenic intoxication. Twenty-four Wistar rats weighing between 150 and 160 g were randomly assigned into four groups. Group 1 received sodium arsenite (1.5 mg/kg b.w.) once a day, Group 2 received GdCl3 (2 mg/kg b.w.) once, 24 hours before commencing the arsenite (1.5 mg/kg b.w.) treatment. Group 3 received GdCl3 (2 mg/kg b.w.) once and subsequently given distilled water. Group 4 received distilled water only. The treatments were daily by oral gavage and lasted for 28 days...
February 2, 2017: General Physiology and Biophysics
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