keyword
https://read.qxmd.com/read/36437811/impact-of-lactiplantibacillus-plantarum-inducia-on-metabolic-and-antioxidative-response-in-cholesterol-and-bmi-variable-indices-randomised-double-blind-placebo-controlled-trials
#21
RANDOMIZED CONTROLLED TRIAL
J Štšepetova, M Rätsep, O Gerulis, A Jõesaar, M Mikelsaar, E Songisepp
Probiotics may have potential in reducing cardiovascular disease (CVD) risk in middle-aged persons with borderline metabolic indices. The ability of potential probiotic Lactiplantibacillus plantarum Inducia to reduce CVD risk factors in persons with variable cholesterol and body mass indices (BMI) was assessed. In two parallel-armed double-blind placebo-controlled interventions (n=136) and (n=104), participants daily received either test yoghurt (Inducia) or placebo yoghurt. BMI, blood pressure, plasma glucose, cholesterol, high-sensitivity C-reactive protein (hs-CRP), oxidative stress and immunological markers were measured...
March 14, 2023: Beneficial Microbes
https://read.qxmd.com/read/36420478/alteration-in-redox-status-and-lipoprotein-profile-in-covid-19-patients-with-mild-moderate-and-severe-pneumonia
#22
JOURNAL ARTICLE
Miodrag Lalosevic, Jelena Kotur-Stevuljevic, Jelena Vekic, Manfredi Rizzo, Tijana Kosanovic, Iva Perovic Blagojevic, Aleksandra Zeljkovic, Danilo Jeremic, Marija Mihajlovic, Aleksa Petkovic, Lejla Hajdarpasic, Marjana Djordjevic, Violeta Dobrilovic, Sanja Erceg, Sanja Vujcic, Jelena Marjanovic, Jovana Milijic Jovanovic, Jovica Saponjski, Natasa Bogavac-Stanojevic
BACKGROUND: Metabolic alterations, particularly disorders of lipoprotein metabolism in COVID-19, may affect the course and outcome of the disease. This study aims at evaluating the lipoprotein profile and redox status in SARS-CoV-2 infected patients with different pneumonia severity and their association with lethal outcomes. METHODS: The prospective cohort study was performed on 98 COVID-19 patients with mild, moderate, and severe pneumonia. Lipid and inflammatory parameters, lipoprotein subclasses, and redox status biomarkers were determined at the study entry and after one week...
2022: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/36218037/circulatory-soluble-lox-1-is-a-novel-predictor-for-coronary-artery-disease-patients
#23
JOURNAL ARTICLE
Md Sayed Ali Sheikh
BACKGROUND: This study investigated the biomarker effect of soluble lectin-like oxidised low-density lipoprotein (sLOX-1) levels for the evaluation of stable and unstable coronary heart disease, correlating it with aging. METHODS: This case-control study was conducted at the Cardiology Department of Xiangya Hospital between June 2015 and September 2018. Stable coronary artery disease (CAD) patients were confirmed by an invasive coronary angiogram, and American College of Cardiology as well as European Cardiology Society clinical protocols were used for the diagnosis of unstable CAD subjects...
October 11, 2022: Cardiovascular Journal of Africa
https://read.qxmd.com/read/36217887/effects-of-lysosomal-low-density-lipoprotein-oxidation-by-ferritin-on-macrophage-function
#24
JOURNAL ARTICLE
Oluwatosin O Ojo, David S Leake
We have previously demonstrated that low density lipoprotein (LDL) can be oxidised by iron in the lysosomes of macrophages. Some of the iron content of lysosomes might be delivered through autophagy of ferritin (the main iron-storage protein in the body). We have now investigated the effects of ferritin-mediated LDL oxidation on macrophage function. The addition of ferritin to human THP-1 cells and human monocyte-derived macrophages increased lysosomal lipid peroxidation, as shown by LPO-Foam, a fluorescent probe targetted to lysosomes...
October 11, 2022: Free Radical Research
https://read.qxmd.com/read/36140371/relationship-between-renal-function-fibrin-clot-properties-and-lipoproteins-in-anticoagulated-patients-with-atrial-fibrillation
#25
JOURNAL ARTICLE
Wern Yew Ding, Ian G Davies, Dhiraj Gupta, Gregory Y H Lip
Background : Mechanisms by which chronic kidney disease (CKD) influences fibrin clot properties in atrial fibrillation (AF) remain ill-defined. We aimed to investigate the effects of AF and CKD on fibrin clot properties and lipoproteins, and determine the relationship between these factors. Methods : Prospective cross-sectional study of patients recruited from cardiology services in Liverpool between September 2019 and October 2021. Primary groups consisted of anticoagulated AF patients with and without CKD in a 1:1 ratio...
September 13, 2022: Biomedicines
https://read.qxmd.com/read/36012465/oxidised-low-density-lipoprotein-induced-platelet-hyperactivity-receptors-and-signalling-mechanisms
#26
REVIEW
Martin Berger, Khalid M Naseem
Dyslipidaemia leads to proatherogenic oxidative lipid stress that promotes vascular inflammation and thrombosis, the pathologies that underpin myocardial infarction, stroke, and deep vein thrombosis. These prothrombotic states are driven, at least in part, by platelet hyperactivity, and they are concurrent with the appearancxe of oxidatively modified low-density lipoproteins (LDL) in the circulation. Modified LDL are heterogenous in nature but, in a general sense, constitute a prototype circulating transporter for a plethora of oxidised lipid epitopes that act as danger-associated molecular patterns...
August 16, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35994001/oxldl-induces-il-1%C3%AE-release-from-human-ec-and-vsmc-via-different-caspase-1-dependent-mechanisms
#27
JOURNAL ARTICLE
Majid Al Mansouri, Pooja Atul Patel, Janet Chamberlain, Sheila Francis
Atherosclerosis is characterised by disturbed blood flow due to abnormal lipid and cell accumulation within arterial layers. Modified cholesterol forms such as oxidised low-density lipoprotein (oxLDL) enter cells altering their phenotype, triggering over exuberant repair and arterial occlusion, myocardial infarction or stroke. We hypothesised that oxLDL enters vascular wall cells and induces IL-1β secretion, potentially via a caspase-1/NLRP3 mechanism. Human coronary artery endothelial cells (HCAEC) and smooth muscle cells (VSMC), isolated from different donors, were cultured and stimulated (primed) with pro-inflammatory cytokines TNFα and IL-1α (10 ng/ml each, for 48 hours), followed by incubation with human oxLDL (10-50ug/ml) for - up to 6 hours...
August 1, 2022: Vascular biology
https://read.qxmd.com/read/35855629/mir-550a-3p-restores-damaged-vascular-smooth-muscle-cells-by-inhibiting-thrombomodulin-in-an-em-in-vitro-em-atherosclerosis-model
#28
JOURNAL ARTICLE
Shiyuan Chen, Longfei Zhang, Benchi Feng, Wei Wang, Delang Liu, Xinyu Zhao, Chaowen Yu, Xiaogao Wang, Yong Gao
Thrombomodulin (TM) is involved in the pathological process of atherosclerosis; however, the underlying mechanism remains unclear. Oxidised low-density lipoprotein (Ox-LDL; 100 μg/mL) was used to induce human vascular smooth muscle cells (HVSMCs) into a stable atherosclerotic cell model. The expression levels of miR-550a-3p and TM were detected by real-time reverse transcription-polymerase chain reaction. Cell proliferation was estimated using CCK8 and EDU assays. Wound scratch and transwell assays were used to measure the ability of cells to invade and migrate...
July 19, 2022: European Journal of Histochemistry: EJH
https://read.qxmd.com/read/35384137/foamy-macrophages-potentially-inhibit-tuberculous-wound-healing-by-inhibiting-the-tlrs-nf-%C3%AE%C2%BAb-signalling-pathway
#29
JOURNAL ARTICLE
Peng Wang, Bin Yin, Zexin Zhang, Shuting Mao, Wu Bao, Wenqin Lian, Yueying Fan, Chao Hong, Yingjun Su, Chiyu Jia
To characterise the distribution, classification, and quantity of foamy macrophages (FMs) in tuberculous wound tissue and the relationship between FM and delayed healing of tuberculous wounds. Morphological studies were performed to explore the distribution of FM and Mycobacterium tuberculosis (Mtb) in tuberculous wounds, with acute and chronic wounds included for comparison. Phorbol-12-myristate-13-acetate stimulation-differentiated THP-1 cells were treated with Mtb to induce their differentiation into FM with oxidised low-density lipoprotein treatment serving as a control...
April 6, 2022: Wound Repair and Regeneration
https://read.qxmd.com/read/34882371/role-of-cd36-expression-on-circulating-monocytes-subsets-in-children-on-regular-hemodialysis
#30
JOURNAL ARTICLE
Noha Mansour, Manal Abdel-Salam, Reham Hammad, Shimaa Moustafa, Hala Maghraby
Cardiovascular diseases are common in children with chronic kidney disease (CKD). According to studies, monocytes play a role in atherosclerotic vascular disorders. CD36 promotes the binding of oxidised low-density lipoprotein (oxLDL) on monocytes, however its role in atherosclerosis is unclear. We aimed to assess the frequency of monocyte subsets in CKD children, and to determine CD36 differential expression on monocyte subsets and its association with the risk of atherosclerotic incidents in those patients...
October 2021: Egyptian Journal of Immunology
https://read.qxmd.com/read/34708098/the-placebo-controlled-effect-of-percutaneous-coronary-intervention-on-exercise-induced-changes-in-anti-malondialdehyde-ldl-antibody-levels-in-stable-coronary-artery-disease-a-substudy-of-the-orbita-trial
#31
JOURNAL ARTICLE
Adam Hartley, Matthew Shun-Shin, Mikhail Caga-Anan, Christopher Rajkumar, Alexandra N Nowbar, Michael Foley, Darrel P Francis, Dorian O Haskard, Ramzi Y Khamis, Rasha K Al-Lamee
Aim: Malondialdehyde-modified low-density lipoprotein (MDA-LDL) forms a significant component of oxidised LDL. The effects of exercise on levels of MDA-LDL and anti-MDA-LDL antibodies are not well-understood. Furthermore, it is not known whether these can be modified in patients with coronary artery disease by percutaneous coronary intervention (PCI). Methods: The Objective Randomised Blinded Investigation with optimal medical Therapy of Angioplasty in stable angina (ORBITA) trial was the first blinded, multi-centre randomised trial of PCI vs...
2021: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/34490366/perivascular-adipose-derived-exosomes-reduce-foam-cell-formation-by-regulating-expression-of-cholesterol-transporters
#32
JOURNAL ARTICLE
Yan Liu, Yan Sun, Xuze Lin, Dai Zhang, Chengping Hu, Jinxing Liu, Yong Zhu, Ang Gao, Hongya Han, Meng Chai, Jianwei Zhang, Yujie Zhou, Yingxin Zhao
Background: Accumulating evidence demonstrates that perivascular adipose tissue (PVAT) plays an important role in maintaining vascular homeostasis. The formation of macrophage foam cells is a central feature of atherosclerosis. This study aimed to evaluate the effect of PVAT-derived exosomes (EXOs) on the lipid accumulation of macrophages and verify the anti-atherogenic characteristics of PVAT. Methods and Results: We extracted EXOs from the PVAT and subcutaneous adipose tissue (SCAT) of wild-type C57BL/6J mice...
2021: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/34377468/native-and-oxidised-lipoproteins-negatively-regulate-the-serum-amyloid-a-induced-nlrp3-inflammasome-activation-in-human-macrophages
#33
JOURNAL ARTICLE
Katariina Nurmi, Katri Niemi, Ilona Kareinen, Kristiina Silventoinen, Martina B Lorey, Yan Chen, Vesa-Petteri Kouri, Jukka Parantainen, Timo Juutilainen, Katariina Öörni, Petri T Kovanen, Dan Nordström, Sampsa Matikainen, Kari K Eklund
Objectives: The NLRP3 inflammasome plays a key role in arterial wall inflammation. In this study, we elucidated the role of serum lipoproteins in the regulation of NLRP3 inflammasome activation by serum amyloid A (SAA) and other inflammasome activators. Methods: The effect of lipoproteins on the NLRP3 inflammasome activation was studied in primary human macrophages and THP-1 macrophages. The effect of oxidised low-density lipoprotein (LDL) was examined in an in vivo mouse model of SAA-induced peritoneal inflammation...
2021: Clinical & Translational Immunology
https://read.qxmd.com/read/34325289/lox-1-expression-is-reduced-in-placenta-from-pregnancies-complicated-by-preeclampsia-and-in-hypoxic-cytotrophoblast
#34
JOURNAL ARTICLE
Natasha de Alwis, Sally Beard, Natalie K Binder, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Owen Stock, Katie M Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Stephen Tong, Natalie J Hannan
OBJECTIVES: The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is upregulated in the maternal vasculature in preeclampsia, and contributes to oxidative stress and endothelial dysfunction. However, its function in the placenta is unclear. This paper investigated LOX-1 expression in models of placental dysfunction and preeclampsia, and whether candidate therapeutics for preeclampsia could alter its expression. STUDY DESIGN: Placentas were collected from preterm pregnancies and cases of preterm preeclampsia and fetal growth restriction...
August 2021: Pregnancy Hypertension
https://read.qxmd.com/read/34092505/critical-role-of-lox-1-pcsk9-axis-in-the-pathogenesis-of-atheroma-formation-and-its-instability
#35
REVIEW
Jonathan Tam, Finosh Thankam, Devendra K Agrawal, Mohamed M Radwan
Cardiovascular disease (CVD) is a major contributor to annual deaths globally. Atherosclerosis is a prominent risk factor for CVD. Although significant developments have been recently made in the prevention and treatment, the molecular pathology of atherosclerosis remains unknown. Interestingly, the recent discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) introduced a new avenue to explore the molecular pathogenesis and novel management strategies for atherosclerosis. Initial research focussed on the PCSK9-mediated degradation of low density lipoprotein receptor (LDLR) and subsequent activation of pro-inflammatory pathways by oxidised low density lipoprotein (ox-LDL)...
June 3, 2021: Heart, Lung & Circulation
https://read.qxmd.com/read/33981434/the-up-to-date-pathophysiology-of-kawasaki-disease
#36
REVIEW
Toshiro Hara, Kenichiro Yamamura, Yasunari Sakai
Kawasaki disease (KD) is an acute systemic vasculitis of an unknown aetiology. A small proportion of children exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or infected by Yersinia reproducibly develop principal symptoms of KD in various ethnic areas, but not in all studies. These microbes provoke a rapid cell-damaging process, called 'pyroptosis', which is characterised by a subsequent release of proinflammatory cellular components from damaged endothelial and innate immune cells. In agreement with these molecular events, patients with KD show elevated levels of damage-associated molecular patterns derived from cell death...
2021: Clinical & Translational Immunology
https://read.qxmd.com/read/33932293/low-density-neutrophils-in-chronic-graft-versus-host-disease-cgvhd-are-primarily-immature-cd10-and-enhance-t-cell-activation
#37
JOURNAL ARTICLE
Nick C Matthews, Charlotte S Burton, Arun Alfred
Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogeneic haematopoietic stem cell transplantation. Low density neutrophils (LDNs) in autoimmunity, which shares disease features with cGVHD, are proinflammatory, whereas those in cancer and sepsis suppress T cell immunity. Mature LDNs can be distinguished from immature LDNs on the basis of expression of CD10 and suppressive neutrophils can be identified using lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) expression. The functionality of LDNs in cGVHD has not been specifically investigated...
August 2021: Clinical and Experimental Immunology
https://read.qxmd.com/read/33867709/association-of-oxidative-stress-with-disease-activity-and-damage-in-systemic-lupus-erythematosus-a-cross-sectional-study-from-a-tertiary-care-centre-in-southern-india
#38
JOURNAL ARTICLE
Sanjeev Shruthi, Molly Mary Thabah, Bobby Zachariah, Vir Singh Negi
To study oxidative stress in systemic lupus erythematosus (SLE) by estimating serum oxidised LDL (OxLDL), 8-hydroxy-2'-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and total anti-oxidant status and to correlate with SLE disease activity and disease damage. Eighty SLE patients satisfying the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) 2012 criteria and 80 healthy controls were studied. Exclusion criteria were infections, renal insufficiency, other connective tissue diseases, drug-induced lupus, smoking, alcohol consumption...
April 2021: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/33639994/changes-in-pcsk-9-and-apolipoprotein-b100-in-niemann-pick-disease-after-enzyme-replacement-therapy-with-olipudase-alfa
#39
JOURNAL ARTICLE
Bethanie Garside, Jan Hoong Ho, See Kwok, Yifen Liu, Shaishav Dhage, Rachelle Donn, Zohaib Iqbal, Simon A Jones, Handrean Soran
BACKGROUND: Enzyme replacement therapy (ERT) with olipudase alfa, a recombinant human acid sphingomyelinase (rhASM), is being developed to treat patients with ASM deficiency (ASMD), commonly known as Niemann-Pick disease (NPD) types A or B. This study assessed the effect of ERT on lipid parameters and inflammatory markers. METHODS: Serum and plasma samples from five adults with NPD type B (NPD-B) who received olipudase alfa ERT for 26 weeks were analysed. We also collected fasting blood samples from fifteen age- and sex-matched participants as reference and comparison group...
February 27, 2021: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/33633187/mitochondrial-function-and-oxidative-stress-markers-in-higher-frequency-episodic-migraine
#40
JOURNAL ARTICLE
Elena C Gross, Niveditha Putananickal, Anna-Lena Orsini, Deborah R Vogt, Peter S Sandor, Jean Schoenen, Dirk Fischer
Increasing evidence points towards the role of mitochondrial functioning, energy metabolism, and oxidative stress in migraine. However not all previous research has been conclusive and some mitochondrial function/oxidative stress markers have not yet been examined. To this end, alpha-lipoic acid (ALA), total thiols, total plasma antioxidant capacity (TAC), lipid peroxide (PerOx), oxidised LDL (oxLDL), HbA1c and lactate were determined in the serum of 32 higher frequency episodic migraineurs (5-14 migraine days/ months, 19 with aura, 28 females) in this cross-sectional study...
February 25, 2021: Scientific Reports
keyword
keyword
87899
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.