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https://www.readbyqxmd.com/read/27884142/dna-methylation-patterns-associated-with-oxidative-stress-in-an-ageing-population
#1
Åsa K Hedman, Mihkel Zilmer, Johan Sundström, Lars Lind, Erik Ingelsson
BACKGROUND: Oxidative stress has been related to type 2 diabetes (T2D) and cardiovascular disease (CVD), the leading global cause of death. Contributions of environmental factors such as oxidative stress on complex traits and disease may be partly mediated through changes in epigenetic marks (e.g. DNA methylation). Studies relating differential methylation with intermediate phenotypes and disease endpoints may be useful in identifying additional candidate genes and mechanisms involved in disease...
November 25, 2016: BMC Medical Genomics
https://www.readbyqxmd.com/read/27879044/clustering-according-to-urolithin-metabotype-explains-the-interindividual-variability-in-the-improvement-of-cardiovascular-risk-biomarkers-in-overweight-obese-individuals-consuming-pomegranate-a-randomised-clinical-trial
#2
Antonio González-Sarrías, Rocío García-Villalba, María Romo-Vaquero, Cesarettin Alasalvar, Asim Örem, Pilar Zafrilla, Francisco A Tomás-Barberán, María V Selma, Juan Carlos Espín
SCOPE: The pomegranate lipid-lowering properties remain controversial, probably due to the interindividual variability in polyphenol (ellagitannins) metabolism. OBJECTIVE: We aimed at investigating whether the microbial-derived ellagitannin-metabolizing phenotypes, i.e. urolithin metabotypes A, (UM-A), B (UM-B) and 0 (UM-0), influence the effects of pomegranate extract (PE) consumption on eighteen cardiovascular risk biomarkers in healthy overweight-obese individuals...
November 23, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27842906/metformin-preconditioned-adipose-derived-mesenchymal-stem-cells-is-a-better-option-for-the-reversal-of-diabetes-upon-transplantation
#3
Nitya Shree, Ramesh R Bhonde
Metformin is used worldwide as an insulin sensitizer. Adipose derived mesenchymal stem cells have shown promising results in the reducing hyperglycemia. We examined whether preconditioning of adipose derived mesenchymal stem cells (ASCs) with metformin could have a better therapeutic value for the reversal of type 2 diabetes. We compared the effect of metformin, ASCs and metformin preconditioned ASCs (MetASCs) in high fat diet induced C57BL/6 mice by injecting the cells intramuscularly only once where as metformin was given at a concentration of 300mg per kg body weight orally daily...
November 11, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27780284/effect-of-continuous-and-intermittent-exercises-on-oxidised-hdl-and-ldl-lipids-in-runners
#4
I A Välimäki, T Vuorimaa, M Ahotupa, T Vasankari
We studied the effects of different types of exercises on the concentrations of oxidised HDL (oxHDLlipids) and LDL lipids (oxLDLlipids), serum lipids, antioxidant potential, paraoxonase and malondialdehyde in endurance runners by performing both a 40-min continuous run (velocity corresponding to 80% VO2max) and a 40-min intermittent run (2-min run, velocity corresponding to 100% VO2max, and 2-min rest) using a treadmill. Blood samples were taken before exercise, after 20 and 40 min of exercise, and 15 and 90 min after the end of exercise...
October 25, 2016: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/27581680/statin-action-enriches-hdl3-in-polyunsaturated-phospholipids-and-plasmalogens-and-reduces-ldl-derived-phospholipid-hydroperoxides-in-atherogenic-mixed-dyslipidemia
#5
Alexina Orsoni, Patrice Thérond, Ricardo Tan, Philippe Giral, Paul Robillard, Anatol Kontush, Peter J Meikle, M John Chapman
Atherogenic mixed dyslipidemia associates with oxidative stress and defective HDL antioxidative function in metabolic syndrome (MetS). The impact of statin treatment on the capacity of HDL to inactivate LDL-derived, redox-active phospholipid hydroperoxides (PCOOHs) in MetS is indeterminate. Insulin-resistant, hypertriglyceridemic, hypertensive, obese males were treated with pitavastatin (4 mg/day) for 180 days, resulting in marked reduction in plasma TGs (-41%) and LDL-cholesterol (-38%), with minor effects on HDL-cholesterol and apoAI...
November 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27547436/lauric-acid-rich-medium-chain-triglycerides-can-substitute-for-other-oils-in-cooking-applications-and-may-have-limited-pathogenicity
#6
REVIEW
Mark F McCarty, James J DiNicolantonio
Recently, medium-chain triglycerides (MCTs) containing a large fraction of lauric acid (LA) (C12)-about 30%-have been introduced commercially for use in salad oils and in cooking applications. As compared to the long-chain fatty acids found in other cooking oils, the medium-chain fats in MCTs are far less likely to be stored in adipose tissue, do not give rise to 'ectopic fat' metabolites that promote insulin resistance and inflammation, and may be less likely to activate macrophages. When ingested, medium-chain fatty acids are rapidly oxidised in hepatic mitochondria; the resulting glut of acetyl-coenzyme A drives ketone body production and also provokes a thermogenic response...
2016: Open Heart
https://www.readbyqxmd.com/read/27475954/survival-or-death-a-dual-role-for-autophagy-in-stress-induced-pericyte-loss-in-diabetic-retinopathy
#7
Dongxu Fu, Jeremy Y Yu, Shihe Yang, Mingyuan Wu, Samar M Hammad, Anna R Connell, Mei Du, Junping Chen, Timothy J Lyons
AIMS/HYPOTHESIS: Intra-retinal extravasation and modification of LDL have been implicated in diabetic retinopathy: autophagy may mediate these effects. METHODS: Immunohistochemistry was used to detect autophagy marker LC3B in human and murine diabetic and non-diabetic retinas. Cultured human retinal capillary pericytes (HRCPs) were treated with in vitro-modified heavily-oxidised glycated LDL (HOG-LDL) vs native LDL (N-LDL) with or without autophagy modulators: green fluorescent protein-LC3 transfection; small interfering RNAs against Beclin-1, c-Jun NH(2)-terminal kinase (JNK) and C/EBP-homologous protein (CHOP); autophagy inhibitor 3-MA (5 mmol/l) and/or caspase inhibitor Z-VAD-fmk (100 μmol/l)...
October 2016: Diabetologia
https://www.readbyqxmd.com/read/27378363/association-between-plasma-lipoprotein-levels-and-bioprosthetic-valve-structural-degeneration
#8
Mohamed Jalloul Nsaibia, Ablajan Mahmut, Haifa Mahjoub, Abdellaziz Dahou, Rihab Bouchareb, Marie-Chloé Boulanger, Jean-Pierre Després, Yohan Bossé, Benoît J Arsenault, Eric Larose, Philippe Pibarot, Patrick Mathieu
INTRODUCTION: Structural valve degeneration (SVD) leads to the failure of aortic valve bioprostheses. It is suspected that lipid-derived factors could play a role in SVD. We hypothesised that oxidised low-density lipoprotein (OxLDL), OxLDL/LDL, OxLDL/high-density lipoprotein (OxLDL/HDL) and proprotein convertase subtilisin/kexin 9 (PCSK9) may be associated with SVD. METHODS: We included 199 patients who underwent an aortic valve replacement with a bioprosthesis and had an echocardiography follow-up to evaluate the function of the prosthesis...
July 4, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27367723/an-intervention-with-mineral-water-decreases-cardiometabolic-risk-biomarkers-a-crossover-randomised-controlled-trial-with-two-mineral-waters-in-moderately-hypercholesterolaemic-adults
#9
Laura Toxqui, M Pilar Vaquero
Water intake is essential for health maintenance and disease prevention. The effects of an intervention with two mineral waters, sodium-bicarbonated mineral water (BW) or control mineral water low in mineral content (CW), on cardiometabolic risk biomarkers were studied. In a randomised-controlled crossover-trial, sixty-four moderately hypercholesterolaemic adults were randomly assigned to consume 1 L/day of either BW (sodium, 1 g/L; bicarbonate, 2 g/L) or CW with the main meals for eight weeks, separated by an eight-week washout period...
2016: Nutrients
https://www.readbyqxmd.com/read/27306616/extravascular-modified-lipoproteins-a-role-in-the-propagation-of-diabetic-retinopathy-in-a-mouse-model-of-type-1-diabetes
#10
Jeremy Y Yu, Mei Du, Michael H Elliott, Mingyuan Wu, Dongxu Fu, Shihe Yang, Arpita Basu, Xiaowu Gu, Jian-Xing Ma, Christopher E Aston, Timothy J Lyons
AIMS/HYPOTHESIS: We aimed to determine whether plasma lipoproteins, after leakage into the retina and modification by glycation and oxidation, contribute to the development of diabetic retinopathy in a mouse model of type 1 diabetes. METHODS: To simulate permeation of plasma lipoproteins into retinal tissues, streptozotocin-induced mouse models of diabetes and non-diabetic mice were challenged with intravitreal injection of human 'highly-oxidised glycated' low-density lipoprotein (HOG-LDL), native- (N-) LDL, or the vehicle PBS...
September 2016: Diabetologia
https://www.readbyqxmd.com/read/27197628/effect-of-long-term-ingestion-of-weakly-oxidised-flaxseed-oil-on-biomarkers-of-oxidative-stress-in-ldl-receptor-knockout-mice
#11
M S Nogueira, M C Kessuane, A A B Lobo Ladd, F V Lobo Ladd, B Cogliati, I A Castro
The effect of oxidised fatty acids on atherosclerosis progression is controversial. Thus, our objective was to evaluate the effect of long-term consumption of weakly oxidised PUFA from flaxseed oil on oxidative stress biomarkers of LDL-receptor(-/-) mice. To test our hypothesis, mice were separated into three groups. The first group received a high-fat diet containing fresh flaxseed oil (CONT-), the second was fed the same diet prepared using heated flaxseed oil (OXID), and the third group received the same diet containing fresh flaxseed oil and had diabetes induced by streptozotocin (CONT+)...
July 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27134858/paraoxonase-activity-and-lipid-profile-in-paediatric-nephrotic-syndrome-a-cross-sectional-study
#12
Vijayetha P Patil, Anuradha B Patil, Vidya S Patil, Deepti G Ingleshwar
INTRODUCTION: Dyslipidaemia of Nephrotic Syndrome (NS) is known to be linked to oxidative reactions and atherosclerosis. Paraoxonase (PON1) has been implicated in the prevention of Low Density Lipoprotein (LDL) lipid peroxidation and also degrades biologically active oxidised lipids in lipoprotein. AIM: The present study was taken up to assess PON1 levels in paediatric nephrotic syndrome and also to see if any correlation exists between lipid parameters and PON1...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27006237/hydroxytyrosol-in-functional-hydroxytyrosol-enriched-biscuits-is-highly-bioavailable-and-decreases-oxidised-low-density-lipoprotein-levels-in-humans
#13
Raquel Mateos, Sara Martínez-López, Gema Baeza Arévalo, Miryam Amigo-Benavent, Beatriz Sarriá, Laura Bravo-Clemente
Hydroxytyrosol (HT) and its derivatives in olive oil protect low-density lipoproteins (LDL) against oxidation. Biscuits could be a convenient alternative to broaden consumers' choice of HT-rich foods, although the biscuit matrix could affect HT bioavailability. We performed a crossover, randomized, double-blind study to evaluate HT bioavailability in HT-enriched biscuits (HT-B) versus non-enriched biscuits (C-B), and the effects on oxidative postprandial status. On two separate days, 13 subjects consumed 30 g of C-B or HT-B (5...
August 15, 2016: Food Chemistry
https://www.readbyqxmd.com/read/27004373/inhibitory-effect-of-puerarin-on-vascular-smooth-muscle-cells-proliferation-induced-by-oxidised-low-density-lipoprotein-via-suppressing-erk-1-2-phosphorylation-and-pcna-expression
#14
Yanwu Hu, Kai Liu, Sun Bo, Mengtong Yan, Yang Zhang, Chunsheng Miao, Liqun Ren
Puerarin, an isoflavonoid isolated from the traditional Chinese herbal medicine Pueraria lobata (Wild.) Ohwi, has been shown to process antioxidant, anti-inflammatory, anti-cancer, anti-hypercholesterolemic, and anti-hyperglycemic activities in vivo and in vitro. The aim of the present study was to investigate the antiproliferative effects and the possible mechanisms of puerarin in vascular smooth muscle cells (VSMCs) stimulated with oxidised low-density lipoprotein (ox-LDL). VSMCs were cultured and pretreated with different concentrations of puerarin (0, 1, 10, 50 µM) before stimulated by ox-LDL (50 µg/mL)...
February 2016: Die Pharmazie
https://www.readbyqxmd.com/read/26892129/small-dense-high-density-lipoprotein-3-particles-exhibit-defective-antioxidative-and-anti-inflammatory-function-in-familial-hypercholesterolemia-partial-correction-by-low-density-lipoprotein-apheresis
#15
Hala Hussein, Samir Saheb, Martine Couturier, Marielle Atassi, Alexina Orsoni, Alain Carrié, Patrice Therond, Sandrine Chantepie, Paul Robillard, Eric Bruckert, M John Chapman, Anatol Kontush
BACKGROUND: Familial hypercholesterolemia (FH) features elevated oxidative stress and accelerated atherosclerosis driven by elevated levels of atherogenic lipoproteins relative to subnormal levels of atheroprotective high-density lipoprotein (HDL). Small, dense HDL3 potently protects low-density lipoprotein (LDL) against proinflammatory oxidative damage. OBJECTIVE: To determine whether antioxidative and/or anti-inflammatory activities of HDL are defective in FH and whether such defects are corrected by LDL apheresis...
January 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/26848395/the-relationship-between-oxidised-ldl-endothelial-progenitor-cells-and-coronary-endothelial-function-in-patients-with-chd
#16
Jonathan Watt, Simon Kennedy, Nadeem Ahmed, James Hayhurst, John D McClure, Colin Berry, Roger M Wadsworth, Keith G Oldroyd
OBJECTIVE: The balance between coronary endothelial dysfunction and repair is influenced by many protective and deleterious factors circulating in the blood. We studied the relationship between oxidised low-density lipoprotein (oxLDL), circulating endothelial progenitor cells (EPCs) and coronary endothelial function in patients with stable coronary heart disease (CHD). METHODS: 33 patients with stable CHD were studied. Plasma oxLDL was measured using ELISA, coronary endothelial function was assessed using intracoronary acetylcholine infusion and EPCs were quantified using flow cytometry for CD34(+)/KDR(+) cells...
2016: Open Heart
https://www.readbyqxmd.com/read/26774674/oxidized-ldl-induced-extracellular-trap-formation-in-human-neutrophils-via-tlr-pkc-irak-mapk-and-nadph-oxidase-activation
#17
Deepika Awasthi, Sheela Nagarkoti, Amit Kumar, Megha Dubey, Abhishek Kumar Singh, Priya Pathak, Tulika Chandra, Manoj Kumar Barthwal, Madhu Dikshit
Neutrophil extracellular traps (NETs) formation was initially linked with host defence and extracellular killing of pathogens. However, recent studies have highlighted their inflammatory potential. Oxidized low density lipoprotein (oxLDL) has been implicated as an independent risk factor in various acute or chronic inflammatory diseases including systemic inflammatory response syndrome (SIRS). In the present study we investigated effect of oxLDL on NETs formation and elucidated the underlying signalling mechanism...
April 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/26710938/acute-modification-in-plasma-lipid-levels-in-ultramarathon-runners
#18
Luiz Gustavo Marin Emed, Daniela Gunther Passaglia, Surya T Guerios, Paula G D João, André I S Moser, Dulcinéia S P Abdalla, Luis Cesar Guarita-Souza, Emanuella Stella Mikilita, Cristina Pellegrino Baena, Ana Beatriz Brenner Affonso da Costa, José Rocha Faria-Neto
We aimed to evaluate the effects of a 24-h ultramarathon, an aerobic test of high physical load, on lipid profile and apolipoproteins B (ApoB) and A1 (ApoA1) levels, minimally modified low-density lipoprotein (LDL), and oxidised LDL. Prospective evaluation of 16 male athletes who participated in an ultramarathon run, where the objective was to run the greatest distance possible in 24 h. Fourteen participants completed the run. The mean distance achieved was 133.1 km (maximum of 169.6 km). There was a trend in reduction of triglycerides and total cholesterol (P = 0...
September 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/26674304/conventional-and-advanced-lipid-parameters-in-premature-coronary-artery-disease-patients-in-india
#19
Sanjiv Kumar Bansal, Sarita Agarwal, Mridul Kumar Daga
BACKGROUND: Coronary artery disease (CAD) is the leading cause of death worldwide and has assumed alarming proportions in India with gradual increase in its incidence and prevalence over the last decade. India is in the middle of epidemic of coronary artery disease which is leading cause of hospital admissions, morbidity and mortality. In the Indian population, there is higher tendency to develop CAD at a younger age, which cannot be explained on the basis of conventional lipid parameters...
November 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26671914/-dual-action-of-vitamin-c-versus-degradation-and-supplementation
#20
REVIEW
Katarzyna Kaliś
The article discusses vitamin C from the point of view of its supplementation with food and in the form of oral supplements. The dual action of vitamin C is connected with the presence of oxygen, which may reduce the amount of the vitamin in food products, influence thermal resistance, cause degradation and show an antioxidation effect. Vitamin C stimulates the immune cells and collagen synthesis. It may protect the LDL fraction against oxidation, and therefore it is interesting for cosmetology, rheumatology, immunology and dietetics...
2015: Postȩpy Higieny i Medycyny Doświadczalnej
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