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NaHS and vasodilation

Marcin Magierowski, Katarzyna Magierowska, Magdalena Hubalewska-Mazgaj, Marcin Surmiak, Zbigniew Sliwowski, Mateusz Wierdak, Slawomir Kwiecien, Anna Chmura, Tomasz Brzozowski
Hydrogen sulfide (H2 S) and carbon monoxide (CO) exert gastroprotection against acute gastric lesions. We determined the cross-talk between H2 S and CO in gastric ulcer healing process and regulation of gastric blood flow (GBF) at ulcer margin. Male Wistar rats with acetic acid-induced gastric ulcers were treated i.g. throughout 9 days with vehicle (control), NaHS (0.1-10 mg/kg) +/- zinc protoporphyrin (ZnPP, 10 mg/kg), d,l-propargylglycine (PAG, 30 mg/kg), CO-releasing CORM-2 (2.5 mg/kg) +/- PAG...
December 1, 2017: Biochemical Pharmacology
Haiya Pu, Yongmei Hua
Hydrogen sulfide (H2S) is a gas signaling molecule that has multiple influences on physiological and pathological processes in the mammalian body, including vasodilation, neurotransmission, inflammation, hypoxia sensing and bone remodeling. Our previous studies suggested that H2S might be involved in the periodontal tissue remodeling during the orthodontic tooth movement (OTM) via increasing periodontal ligament cell differentiation, tissue mineralization, bone formation and collagen synthesis. The aim of the present study was to investigate the effects of H2S on alveolar bone remodeling that is associated with tooth movement...
December 2017: Molecular Medicine Reports
Ai-Jun Liu, Bin Li, Ming Yang, Yang Liu, Ying-Long Liu, Jun-Wu Su
BACKGROUND: Current knowledge indicates that oxidative damage and the following inflammation is pivotal pathway for myocardial cell death. In recent decades, hydrogen sulfide (H2S) has been identified as a novel endogenous vasodilator and neuromodulator due to its antioxidation capacity. However, whether H2S pretreatment in neonatal mouse cardiomyocytes is a protection effect against oxidative stress remains elusive. METHODS: Primary neonatal mouse cardiomyocytes were isolated and cultured, subsequently, pretreated with the H2S donor, sodium hydrosulfide (NaHS)...
October 5, 2017: Chinese Medical Journal
Martin Caprnda, Tawar Qaradakhi, Joanne L Hart, Nazarii Kobyliak, Radka Opatrilova, Peter Kruzliak, Anthony Zulli
OBJECTIVE: Cardiovascular disease (CVD) caused by atherosclerosis remains a worldwide burden. Hydrogen sulfide is a promising new therapeutic avenue for the treatment of CVD, however reports show exogenous H2 S has both vasodilator and vasoconstrictor effects depending on organ examined, and in vitro studies in animal models which are not resistant to developing atherosclerosis are limited. We sought to determine if rabbit arteries constricted or dilated to hydrogen sulfide. MATERIAL AND METHODS: The aorta, carotid, renal and iliac arteries were harvested from New Zealand White rabbits (n=4) and subjected to a concentration response curve to the fast H2 S releaser NaHS...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Laura V Gonzalez Bosc, Jessica M Osmond, Wieslawa K Giermakowska, Carolyn E Pace, Jennifer L Riggs, Olan Jackson-Weaver, Nancy L Kanagy
Sleep apnea is a risk factor for cardiovascular disease, and intermittent hypoxia (IH, 20 episodes/h of 5% O2-5% CO2 for 7 h/day) to mimic sleep apnea increases blood pressure and impairs hydrogen sulfide (H2S)-induced vasodilation in rats. The enzyme that produces H2S, cystathionine γ-lyase (CSE), is decreased in rat mesenteric artery endothelial cells (EC) following in vivo IH exposure. In silico analysis identified putative nuclear factor of activated T cell (NFAT) binding sites in the CSE promoter. Therefore, we hypothesized that IH exposure reduces Ca(2+) concentration ([Ca(2+)]) activation of calcineurin/NFAT to lower CSE expression and impair vasodilation...
April 1, 2017: American Journal of Physiology. Heart and Circulatory Physiology
Serena Materazzi, Giovanni Zagli, Romina Nassini, Ilenia Bartolini, Stefano Romagnoli, Cosimo Chelazzi, Silvia Benemei, Andrea Coratti, Angelo Raffaele De Gaudio, Riccardo Patacchini
The role of endogenous H2S has been highlighted as a gaseous transmitter. The vascular smooth muscle inhibitory effects of H2S have been characterized in isolated aorta and mesenteric arteries in rats and mice. Our study was aimed at investigating the vascular effects of H2S on human isolated mesenteric arteries and examining the underlying mechanisms involved. All experiments were performed on rings (4-8mm long) of human mesenteric arteries obtained from patients undergoing abdominal surgery. Ethical approval was obtained from the Ethics Committee of the University Hospital of the University of Florence (app...
January 2017: Microvascular Research
Mei Wang, Youyang Hu, Yifei Fan, Yan Guo, Fanglin Chen, Shuo Chen, Qinglin Li, Zhiwu Chen
BACKGROUND/AIM: H2S is a novel vasoactivator. To verify the hypothesis that H2S may act as an endothelium-derived hyperpolarizing factor (EDHF) in the rat cerebrovasculature, the role of H2S in endothelium-derived relaxing factor (EDRF)-mediated responses was investigated. METHODS: Cystathionine-γ-lyase (CSE) was knocked down with an siRNA technique. Artery diameter, hyperpolarization and Ca2+-activated K+ (KCa) current were measured. RESULTS: CSE knockdown was indicated by a decrease in protein and mRNA expression in the rat middle cerebral artery (MCA) and cerebral basilar artery (CBA)...
2016: Journal of Vascular Research
Marcin Magierowski, Katarzyna Magierowska, Jakub Szmyd, Marcin Surmiak, Zbigniew Sliwowski, Slawomir Kwiecien, Tomasz Brzozowski
BACKGROUND: Alendronate is an inhibitor of osteoclast-mediated bone resorption, but its clinical utility is limited due to gastrointestinal complications including bleeding erosions. AIMS: We studied whether potent vasodilators hydrogen sulfide (H2 S) and carbon monoxide (CO) can protect against alendronate-induced gastric lesions in rats exposed to mild stress. METHODS: Three series (A, B, and C) of Wistar rats received alendronate (150-700 mg/kg i...
November 2016: Digestive Diseases and Sciences
Gunay Yetik-Anacak, Gulnur Sevin, Ozge Ozzayım, Mehmet Vehbi Dereli, Asif Ahmed
Reactive oxygen species (ROS) decreases bioavailability of nitric oxide (NO) and impairs NO-dependent relaxations. Like NO, hydrogen sulfide (H2 S) is an antioxidant and vasodilator; however, the effect of ROS on H2 S-induced relaxations is unknown. Here we investigated whether ROS altered the effect of H2 S on vascular tone in mouse aorta and determined whether resveratrol (RVT) protects it via H2 S. Pyrogallol induced ROS formation. It also decreased H2 S formation and relaxation induced by l-cysteine and in mouse aorta...
December 2016: Vascular Pharmacology
Elise R Hedegaard, Anja Gouliaev, Anna K Winther, Daniel D R Arcanjo, Mathilde Aalling, Nirthika S Renaltan, Mark E Wood, Matthew Whiteman, Nini Skovgaard, Ulf Simonsen
Endogenous hydrogen sulfide (H2S) is involved in the regulation of vascular tone. We hypothesized that the lowering of calcium and opening of potassium (K) channels as well as calcium-independent mechanisms are involved in H2S-induced relaxation in rat mesenteric small arteries. Amperometric recordings revealed that free [H2S] after addition to closed tubes of sodium hydrosulfide (NaHS), Na2S, and GYY4137 [P-(4-methoxyphenyl)-P-4-morpholinyl-phosphinodithioic acid] were, respectively, 14%, 17%, and 1% of added amount...
January 2016: Journal of Pharmacology and Experimental Therapeutics
Gunay Yetik-Anacak, Mehmet V Dereli, Gulnur Sevin, Ozge Ozzayım, Yasemin Erac, Asif Ahmed
INTRODUCTION: Resveratrol (RVT) found in red wine protects against erectile dysfunction and relaxes penile tissue (corpus cavernosum) via a nitric oxide (NO) independent pathway. However, the mechanism remains to be elucidated. Hydrogen sulfide (H2 S) is a potent vasodilator and neuromodulator generated in corpus cavernosum. AIMS: We investigated whether RVT caused the relaxation of mice corpus cavernosum (MCC) through H2 S. METHODS: H2 S formation is measured by methylene blue assay and vascular reactivity experiments have been performed by DMT strip myograph in CD1 MCC strips...
October 2015: Journal of Sexual Medicine
Olan Jackson-Weaver, Jessica M Osmond, Jay S Naik, Laura V Gonzalez Bosc, Benjimen R Walker, Nancy L Kanagy
Ca(+) sparks are vascular smooth muscle cell (VSMC) Ca(2+)-release events that are mediated by ryanodine receptors (RyR) and promote vasodilation by activating large-conductance Ca(2+)-activated potassium channels and inhibiting myogenic tone. We have previously reported that exposing rats to intermittent hypoxia (IH) to simulate sleep apnea augments myogenic tone in mesenteric arteries through loss of hydrogen sulfide (H2S)-induced dilation. Because we also observed that H2S can increase Ca(2+) spark activity, we hypothesized that loss of H2S after IH exposure reduces Ca(2+) spark activity and that blocking Ca(2+) spark generation reduces H2S-induced dilation...
December 1, 2015: American Journal of Physiology. Heart and Circulatory Physiology
Kwi Young Kang, Chan Hong Jeon, Sung Jae Choi, Bo Young Yoon, Chan-Bum Choi, Chang Hoon Lee, Chang-Hee Suh, Choong Won Lee, Chul Soo Cho, Eon Jeong Nam, Eun-Mi Koh, Ho-Youn Kim, Hyo Jin Choi, Hyoun-Ah Kim, Jae-Bum Jun, Jaejoon Lee, Jinseok Kim, Jong Dae Ji, Jun Ki Min, Ki Jo Kim, Kichul Shin, Min Wook So, Seong Ryul Kwon, Seong-Kyu Kim, Seong-Su Nah, Seung-Ki Kwok, Soo-Kon Lee, Sung Won Lee, Sung-Hwan Park, Won Park, Yong-Beom Park, Young Ho Lee, Shin-Seok Lee, Dae Hyun Yoo
OBJECTIVES: Pulmonary arterial hypertension (PAH) is a major cause of mortality in connective tissue disease (CTD). The survival rates and mortality-predictive factors of a nationwide registry of Korean patients with CTD-PH measured by echocardiography were determined. METHODS: Patients with CTD-PH were enrolled between April 2008 and December 2012. Hemodynamic parameters and clinical data (WHO-functional class [FC], organ involvement, laboratory tests and treatment agents) were recorded...
September 2017: International Journal of Rheumatic Diseases
Jun Han, Jia-li Xuan, Hao-ran Hu, Zhi-wu Chen
To investigate the effects and potential mechanisms of hyperoside (Hyp) on the vascular endothelium function in middle cerebral artery (MCA) ex vivo in rats. Isolated arterial segments from MCAs of rats were used for surveying vasomotoricity in a pressurized chamber. Transmembrane potential was recorded by using glass microelectrodes to evaluate hyperpolarization. Hyp (1 x 10(-6)-1 x 10(-4) mol . L-1) was utilized to observe the effect on 1 x 10(-7) mol . L-1 U46619-preconstricted MCA in rats. The results showed that 1 x 10(-6)-1 x 10(-4) mol ...
December 2014: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
H Xue, S Zhou, L Xiao, Q Guo, S Liu, Y Wu
As a novel gasotransmitter, hydrogen sulfide (H(2)S) has vasodilating and antihypertensive effects in cardiovascular system. Thus, we hypothesized that H(2)S might have beneficial effects on thoracic endothelial function in two-kidney one-clip (2K1C) rats, a model of renovascular hypertension. Sodium hydrosulfide (NaHS, 56 micromol/kg/day) was administrated intra-peritoneally from the third day after the 2K1C operation. Along with the development of hypertension, the systolic blood pressure (SBP) was measured before the operation and each week thereafter...
2015: Physiological Research
S Takır, G Z Ortaköylü, A Toprak, B S Uydeş-Doğan
Hydrogen sulphide (H2S) is known to be produced endogenously in ocular tissues with the highest levels in the retina and cornea. However, it is yet unclear whether it can modulate retinal arterial tone. Herein, we aimed to investigate the effectiveness and the mechanism of the action of H2S in the isolated bovine retinal arteries. For this purpose, the probable vasorelaxant and inhibitory effects of H2S on vascular reactivity were tested comparatively in the retinal arteries by using the donor, sodium hydrosulphide (NaHS)...
March 2015: Experimental Eye Research
Zaid Altaany, YoungJun Ju, Guangdong Yang, Rui Wang
The gasotransmitter hydrogen sulfide (H(2)S), which is generated by cystathionine γ-lyase (CSE), signals by modifying proteins through S-sulfhydration and potentially other mechanisms. A target protein for H(2)S is endothelial nitric oxide synthase (eNOS), an enzyme that generates nitric oxide (NO), which causes vasodilation. We investigated whether H(2)S-induced S-sulfhydration affected the S-nitrosylation and phosphorylation of eNOS and the functional effects of changes in these posttranslational modifications on eNOS activity...
September 9, 2014: Science Signaling
Pitchai Balakumar, Ying Hui Nyo, Raja Renushia, Devarajan Raaginey, Ann Nah Oh, Rajavel Varatharajan, Sokkalingam A Dhanaraj
Dipyridamole is a platelet inhibitor indicated for the secondary prevention of transient ischemic attack. It inhibits the enzyme phosphodiesterase, elevates cAMP and cGMP levels and prevents platelet aggregation. Dipyridamole inhibits the cellular uptake of adenosine into red blood cells, platelets and endothelial cells that results in increased extracellular availability of adenosine, leading to modulation of cardiovascular function. The antiplatelet action of dipyridamole might offer therapeutic benefits in secondary stroke prevention in combination with aspirin...
September 2014: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Fiaz Ud Din Ahmad, Munavvar A Sattar, Hassaan A Rathore, Yong Chia Tan, Safia Akhtar, Oh Hui Jin, Yen Pei Pei, Nor A Abdullah, Edward J Johns
Oxidative stress and suppressed H2S production lead to increased renal vascular resistance, disturbed glomerular hemodynamics, and abnormal renal sodium and water handling, contribute to the pathogenesis and maintenance of essential hypertension in man and the spontaneously hypertensive rat. This study investigated the impact of H2S and tempol alone and in combination on blood pressure and renal hemodynamics and excretory functions in the SHR. Groups of WKY rats or SHR (n=6) were treated for 4 weeks either as controls or received NaHS (SHR+NaHS), tempol (SHR+Tempol), or NaHS plus tempol (SHR+NaHS +Tempol)...
May 2014: Renal Failure
Kim M Holwerda, Suzanne D Burke, Marijke M Faas, Zsuzsanna Zsengeller, Isaac E Stillman, Peter M Kang, Harry van Goor, Amy McCurley, Iris Z Jaffe, S Ananth Karumanchi, A Titia Lely
Soluble fms-like tyrosine kinase 1 (sFlt1), a circulating antiangiogenic protein, is elevated in kidney diseases and contributes to the development of preeclampsia. Hydrogen sulfide is a vasorelaxant and proangiogenic gas with therapeutic potential in several diseases. Therefore, we evaluated the potential therapeutic effect and mechanisms of action of hydrogen sulfide in an animal model of sFlt1-induced hypertension, proteinuria, and glomerular endotheliosis created by adenovirus-mediated overexpression of sFlt1 in Sprague-Dawley rats...
April 2014: Journal of the American Society of Nephrology: JASN
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