Margo J Reeder, Erin Warshaw, Srikanth Aravamuthan, Donald V Belsito, Johannes Geier, Mark Wilkinson, Amber Reck Atwater, Ian R White, Jonathan I Silverberg, James S Taylor, Joseph F Fowler, Howard I Maibach, Joel G DeKoven, Timo Buhl, Nina Botto, Ana Maria Giménez-Arnau, Rosella Gallo, Christen Mowad, Claudia C V Lang, Vincent A DeLeo, Graham Johnston, Melanie D Pratt, Knut Brockow, Brandon L Adler, Marie-Claude Houle, Heinrich Dickel, Marie Louise A Schuttelaar, JiaDe Yu, Radoslaw Spiewak, Cory Dunnick, Francesca Larese Filon, Skaidra Valiukeviciene, Wolfgang Uter
IMPORTANCE: The common use of isothiazolinones as preservatives is a global cause of allergic contact dermatitis. Differences in allowable concentrations of methylisothiazolinone (MI) exist in Europe, Canada, and the US. OBJECTIVE: To compare the prevalence of positive patch test reactions to the methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) combination and MI alone in North America and Europe from 2009 to 2018. DESIGN, SETTING, AND PARTICIPANTS: This retrospective analysis of North American Contact Dermatitis Group, European Surveillance System on Contact Allergies (ESSCA), and the Information Network of Departments of Dermatology (IVDK) databases included data from patients presenting for patch testing at referral patch test clinics in North America and Europe...
January 18, 2023: JAMA Dermatology