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https://www.readbyqxmd.com/read/29770291/a-review-of-the-nunn-modified-single-patch-technique-for-atrioventricular-septal-defect-repair
#1
REVIEW
Tracy R Geoffrion, Kanchana Singappuli, John S K Murala
Atrioventricular septal defect (AVSD) is a common congenital cardiac surgical problem. Over the years, younger and smaller infants are having operations for this condition before irreversible cardio pulmonary changes occur. Traditionally a single or two patch techniques have been used to repair this defect. However, in the past two decades an innovative method of modified single patch technique popularized by Dr. Graham Nunn has gained worldwide popularity. This review discusses the origin, surgical principles, technique and outcomes of this method, popularly known as Nunn or Australian technique...
April 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29755140/resilience-in-carbonate-production-despite-three-coral-bleaching-events-in-5-years-on-an-inshore-patch-reef-in-the-florida-keys
#2
Derek P Manzello, Ian C Enochs, Graham Kolodziej, Renée Carlton, Lauren Valentino
The persistence of coral reef frameworks requires that calcium carbonate (CaCO3 ) production by corals and other calcifiers outpaces CaCO3 loss via physical, chemical, and biological erosion. Coral bleaching causes declines in CaCO3 production, but this varies with bleaching severity and the species impacted. We conducted census-based CaCO3 budget surveys using the established ReefBudget approach at Cheeca Rocks, an inshore patch reef in the Florida Keys, annually from 2012 to 2016. This site experienced warm-water bleaching in 2011, 2014, and 2015...
2018: Marine Biology
https://www.readbyqxmd.com/read/29718321/telomere-sequence-content-can-be-used-to-determine-alt-activity-in-tumours
#3
Michael Lee, Erdahl T Teber, Oliver Holmes, Katia Nones, Ann-Marie Patch, Rebecca A Dagg, Loretta M S Lau, Joyce H Lee, Christine E Napier, Jonathan W Arthur, Sean M Grimmond, Nicholas K Hayward, Peter A Johansson, Graham J Mann, Richard A Scolyer, James S Wilmott, Roger R Reddel, John V Pearson, Nicola Waddell, Hilda A Pickett
The replicative immortality of human cancer cells is achieved by activation of a telomere maintenance mechanism (TMM). To achieve this, cancer cells utilise either the enzyme telomerase, or the Alternative Lengthening of Telomeres (ALT) pathway. These distinct molecular pathways are incompletely understood with respect to activation and propagation, as well as their associations with clinical outcomes. We have identified significant differences in the telomere repeat composition of tumours that use ALT compared to tumours that do not...
April 30, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29557829/repair-of-exposed-ahmed-glaucoma-valve-tubes-long-term-outcomes
#4
Adi Einan-Lifshitz, Avner Belkin, David Mathew, Nir Sorkin, Clara C Chan, Yvonne M Buys, Graham E Trope, David S Rootman
PURPOSE: To assess the long-term outcomes of GDD exposure repair with corneal lamellar patch graft covered by a buccal mucous membrane graft sutured to surrounding conjunctiva. METHODS: In this retrospective longitudinal study, the charts of all patients who underwent buccal mucous membrane grafts combined with corneal lamellar patch grafts for exposed GDD tubes between the years 2006 to 2013 were reviewed. A minimum follow-up of 3 years was required for inclusion...
March 19, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29553577/phase-1-clinical-study-of-an-embryonic-stem-cell-derived-retinal-pigment-epithelium-patch-in-age-related-macular-degeneration
#5
Lyndon da Cruz, Kate Fynes, Odysseas Georgiadis, Julie Kerby, Yvonne H Luo, Ahmad Ahmado, Amanda Vernon, Julie T Daniels, Britta Nommiste, Shazeen M Hasan, Sakina B Gooljar, Amanda-Jayne F Carr, Anthony Vugler, Conor M Ramsden, Magda Bictash, Mike Fenster, Juliette Steer, Tricia Harbinson, Anna Wilbrey, Adnan Tufail, Gang Feng, Mark Whitlock, Anthony G Robson, Graham E Holder, Mandeep S Sagoo, Peter T Loudon, Paul Whiting, Peter J Coffey
Age-related macular degeneration (AMD) remains a major cause of blindness, with dysfunction and loss of retinal pigment epithelium (RPE) central to disease progression. We engineered an RPE patch comprising a fully differentiated, human embryonic stem cell (hESC)-derived RPE monolayer on a coated, synthetic basement membrane. We delivered the patch, using a purpose-designed microsurgical tool, into the subretinal space of one eye in each of two patients with severe exudative AMD. Primary endpoints were incidence and severity of adverse events and proportion of subjects with improved best-corrected visual acuity of 15 letters or more...
April 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29484072/percutaneous-transgastric-interventional-radiology-operated-duodenoscopy-for-the-identification-of-duodenal-perforation-and-graham-patch-dehiscence
#6
Ravi Nara Srinivasa, Matthew L Osher, Douglas A Murrey, Jordan Bruce Fenlon, Charles Brewerton, Wael E Saad, Jeffrey Forris Beecham Chick
Patients with a Roux-en-Y gastric bypass may be challenging diagnostic and therapeutic dilemmas for gastroenterologists and endoscopists due to anatomic considerations. Pancreaticobiliary limb pathology is particularly difficult to diagnose from standard endoscopic approaches as it often requires double balloon enteroscopy. Percutaneous access and gastrostomy placement into the gastric remnant, however, is a commonly performed procedure by interventional radiology. This report describes the identification of duodenal perforation and Graham patch dehiscence in the pancreaticobiliary limb of a patient with a prior Roux-en-Y gastric bypass who had failed traditional endoscopic measures, using transgastric remnant interventional duodenoscopy and confirmed with methylene blue injection into a periduodenal abscess...
December 2017: Radiology Case Reports
https://www.readbyqxmd.com/read/29468728/european-surveillance-system-on-contact-allergies-essca-polysensitization-2009-2014
#7
Daan Dittmar, Wolfgang Uter, Andrea Bauer, Ana B Fortina, Andreas J Bircher, Magdalena Czarnecka-Operacz, Aleksandra Dugonik, Peter Elsner, Rosella Gallo, Sharizan A Ghaffar, Anna Giménez-Arnau, Graham A Johnston, Beata Kręcisz, Francesca L Filon, Thomas Rustemeyer, Anna Sadowska-Przytocka, Javier Sánchez-Pérez, Axel Schnuch, Dagmar Simon, Radoslaw Spiewak, Philipp Spring, Maria T Corradin, Skaidra Valiukevičienė, Marko Vok, Elke Weisshaar, Mark Wilkinson, Marie L Schuttelaar
BACKGROUND: Polysensitization, defined as being allergic to three or more haptens from the European baseline series, is considered to reflect increased susceptibility to developing a contact allergy, and is likely to be associated with an impaired quality of life. OBJECTIVES: To evaluate the prevalences of polysensitization across Europe and to analyse factors associated with polysensitization. METHODS: Patch test data collected by the European Surveillance System on Contact Allergies (ESSCA; www...
June 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29464766/systemic-and-transdermal-melatonin-administration-prevents-neuropathology-in-response-to-perinatal-asphyxia-in-newborn-lambs
#8
James D S Aridas, Tamara Yawno, Amy E Sutherland, Ilias Nitsos, Michael Ditchfield, Flora Y Wong, Rod W Hunt, Michael C Fahey, Atul Malhotra, Euan M Wallace, Graham Jenkin, Suzanne L Miller
Perinatal asphyxia remains a principal cause of infant mortality and long-term neurological morbidity, particularly in low-resource countries. No neuroprotective interventions are currently available. Melatonin (MLT), a potent antioxidant, anti-inflammatory and antiapoptotic agent, offers promise as an intravenous (IV) or transdermal therapy to protect the brain. We aimed to determine the effect of melatonin (IV or transdermal patch) on neuropathology in a lamb model of perinatal asphyxia. Asphyxia was induced in newborn lambs via umbilical cord occlusion at birth...
May 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29430661/glucose-and-lactate-as-metabolic-constraints-on-presynaptic-transmission-at-an-excitatory-synapse
#9
Sarah J Lucas, Christophe B Michel, Vincenzo Marra, Joshua L Smalley, Matthias H Hennig, Bruce P Graham, Ian D Forsythe
KEY POINTS: Synapses have high energy demands which increase during intense activity. We show that presynaptic terminals can utilise extracellular glucose or lactate to generate energy to maintain synaptic transmission. Reducing energy substrates induces a metabolic stress: presynaptic ATP depletion impaired synaptic transmission through a reduction in the number of functional synaptic vesicle release sites and a slowing of vesicle pool replenishment, without a consistent change in release probability...
May 1, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29274104/designing-connected-marine-reserves-in-the-face-of-global-warming
#10
Jorge G Álvarez-Romero, Adrián Munguía-Vega, Maria Beger, Maria Del Mar Mancha-Cisneros, Alvin N Suárez-Castillo, Georgina G Gurney, Robert L Pressey, Leah R Gerber, Hem Nalini Morzaria-Luna, Héctor Reyes-Bonilla, Vanessa M Adams, Melanie Kolb, Erin M Graham, Jeremy VanDerWal, Alejandro Castillo-López, Gustavo Hinojosa-Arango, David Petatán-Ramírez, Marcia Moreno-Baez, Carlos R Godínez-Reyes, Jorge Torre
Marine reserves are widely used to protect species important for conservation and fisheries and to help maintain ecological processes that sustain their populations, including recruitment and dispersal. Achieving these goals requires well-connected networks of marine reserves that maximize larval connectivity, thus allowing exchanges between populations and recolonization after local disturbances. However, global warming can disrupt connectivity by shortening potential dispersal pathways through changes in larval physiology...
February 2018: Global Change Biology
https://www.readbyqxmd.com/read/28944095/intermolecular-interactions-involving-an-acidic-patch-on-immunoglobulin-variable-domain-and-the-%C3%AE-2-constant-region-mediate-crystalline-inclusion-body-formation-in-the-endoplasmic-reticulum
#11
Haruki Hasegawa, Mei Geng, Randal R Ketchem, Ling Liu, Kevin Graham, Frederick Jacobsen
Full-length immunoglobulins (Igs) are widely considered difficult to crystallize because of their large size, N-linked glycosylation, and flexible hinge region. However, numerous cases of intracellular Ig crystallization are reported in plasma cell dyscrasias. What makes some Ig clones more prone to crystallize during biosynthesis as well as the biochemical and cell biological requirements for this cryptic event are poorly understood. To investigate the underlying process of intracellular Ig crystallization we searched for model IgGs that can induce crystalline inclusions during recombinant overexpression...
2017: Cellular Logistics
https://www.readbyqxmd.com/read/28931666/trpa1-activation-in-a-human-sensory-neuronal-model-relevance-to-cough-hypersensitivity
#12
Rebecca Clarke, Kevin Monaghan, Imad About, Caoimhin S Griffin, Gerard P Sergeant, Ikhlas El Karim, J Graham McGeown, S Louise Cosby, Timothy M Curtis, Lorcan P McGarvey, Fionnuala T Lundy
The cough reflex becomes hyperresponsive in acute and chronic respiratory diseases, but understanding the underlying mechanism is hampered by difficulty accessing human tissue containing both nerve endings and neuronal cell bodies. We refined an adult stem cell sensory neuronal model to overcome the limited availability of human neurones and applied the model to study transient receptor potential ankyrin 1 (TRPA1) channel expression and activation.Human dental pulp stem cells (hDPSCs) were differentiated towards a neuronal phenotype, termed peripheral neuronal equivalents (PNEs)...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28905384/heteromeric-%C3%AE-%C3%AE-glycine-receptors-regulate-excitability-in-parvalbumin-expressing-dorsal-horn-neurons-through-phasic-and-tonic-glycinergic-inhibition
#13
M A Gradwell, K A Boyle, R J Callister, D I Hughes, B A Graham
KEY POINTS: Spinal parvalbumin-expressing interneurons have been identified as a critical source of inhibition to regulate sensory thresholds by gating mechanical inputs in the dorsal horn. This study assessed the inhibitory regulation of the parvalbumin-expressing interneurons, showing that synaptic and tonic glycinergic currents dominate, blocking neuronal or glial glycine transporters enhances tonic glycinergic currents, and these manipulations reduce excitability. Synaptically released glycine also enhanced tonic glycinergic currents and resulted in decreased parvalbumin-expressing interneuron excitability...
December 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28844004/altered-intrinsic-and-synaptic-properties-of-lumbosacral-dorsal-horn-neurons-in-a-mouse-model-of-colitis
#14
Kristen E Farrell, Simon Keely, Marjorie M Walker, Alan M Brichta, Brett A Graham, Robert J Callister
Visceral pain in inflammatory and functional gastrointestinal conditions is a major clinical problem. The exact mechanisms underlying the development of pain, during and after visceral inflammation are unknown. However, clinical and pre-clinical evidence suggests plasticity within the spinal cord dorsal horn is a contributing factor. Here we use an in vivo preparation and patch-clamp electrophysiology to test whether the synaptic and intrinsic properties of superficial dorsal horn (SDH) neurons are altered 5days after the induction of mild colitis in adult male mice (i...
August 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/28762726/intracellular-uncaging-of-cgmp-with-blue-light
#15
Hitesh K Agarwal, Shenyu Zhai, D James Surmeier, Graham C R Ellis-Davies
We have made a new caged cGMP that is photolyzed with blue light. Using our recently developed derivative of 7-diethylaminocourmarin (DEAC) called DEAC450, we synthesized coumarin phosphoester derivatives of cGMP with two negative charges appended to the DEAC450 moiety. DEAC450-cGMP is freely soluble in physiological buffer without the need for any organic cosolvents. With a photolysis quantum yield of 0.18 and an extinction coefficient of 43 000 M-1 cm-1 at 453 nm, DEAC450-cGMP is the most photosensitive caged cGMP made to date...
October 18, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28748570/lichen-planopilaris-in-a-latin-american-chilean-population-demographics-clinical-profile-and-treatment-experience
#16
F Mardones, J Shapiro
BACKGROUND: Lichen planopilaris (LPP) is characterized by lymphocytic infiltrate, fibrosis and potential destruction of the hair follicle. Demographic and clinical studies in LPP are limited, and racial differences have not been thoroughly investigated. AIM: To analyse epidemiological data and clinical profiles of Chilean adults with LPP, and report on the treatments used. METHODS: This was a retrospective review of medical records and clinical follow-up of Chilean adults with a clinical and histopathological diagnosis of LPP...
October 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28539334/spatiotemporal-analysis-of-spontaneous-myogenic-contractions-in-the-urinary-bladder-of-the-rabbit-timing-and-patterns-reflect-reported-electrophysiology
#17
C M Hulls, R G Lentle, Q M King, G W Reynolds, J P Chambers
The dynamics of propagating myogenic contractions in the wall of the resting ex vivo urinary bladder of the rabbit were characterized by spatiotemporal maps and related to cyclic variation in intravesical pressure (Pves). Patches of propagating contractions (PPCs) enlarged and involuted in near synchrony with peaks in Pves [mean 3.85  ± 0.3 cycles per minute (cpm)] and were preceded by regions of stretch. The maximum area of the bladder undergoing contraction (55.28 ± 2.65%) and the sizes of individual PPCs (42...
September 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28467829/whole-genome-landscapes-of-major-melanoma-subtypes
#18
Nicholas K Hayward, James S Wilmott, Nicola Waddell, Peter A Johansson, Matthew A Field, Katia Nones, Ann-Marie Patch, Hojabr Kakavand, Ludmil B Alexandrov, Hazel Burke, Valerie Jakrot, Stephen Kazakoff, Oliver Holmes, Conrad Leonard, Radhakrishnan Sabarinathan, Loris Mularoni, Scott Wood, Qinying Xu, Nick Waddell, Varsha Tembe, Gulietta M Pupo, Ricardo De Paoli-Iseppi, Ricardo E Vilain, Ping Shang, Loretta M S Lau, Rebecca A Dagg, Sarah-Jane Schramm, Antonia Pritchard, Ken Dutton-Regester, Felicity Newell, Anna Fitzgerald, Catherine A Shang, Sean M Grimmond, Hilda A Pickett, Jean Y Yang, Jonathan R Stretch, Andreas Behren, Richard F Kefford, Peter Hersey, Georgina V Long, Jonathan Cebon, Mark Shackleton, Andrew J Spillane, Robyn P M Saw, Núria López-Bigas, John V Pearson, John F Thompson, Richard A Scolyer, Graham J Mann
Melanoma of the skin is a common cancer only in Europeans, whereas it arises in internal body surfaces (mucosal sites) and on the hands and feet (acral sites) in people throughout the world. Here we report analysis of whole-genome sequences from cutaneous, acral and mucosal subtypes of melanoma. The heavily mutated landscape of coding and non-coding mutations in cutaneous melanoma resolved novel signatures of mutagenesis attributable to ultraviolet radiation. However, acral and mucosal melanomas were dominated by structural changes and mutation signatures of unknown aetiology, not previously identified in melanoma...
May 11, 2017: Nature
https://www.readbyqxmd.com/read/28450102/an-in%C3%A2-vitro-study-of-the-role-of-implant-positioning-on-ulnohumeral-articular-contact-in-distal-humeral-hemiarthroplasty
#19
Roxanna E Abhari, Ryan Willing, Graham J W King, James A Johnson
PURPOSE: To investigate the effect of implant positioning on ulnohumeral contact using patient-specific distal humeral (DH) implants. METHODS: Seven reverse-engineered DH implants were manufactured based on computed tomography scans of their osseous geometry. Native ulnae were paired with corresponding native humeri and custom DH implants in a loading apparatus. The ulna was set at 90° of flexion and the humeral component (either native bone or reverse-engineered implant) was positioned from 5° varus to 5° valgus in 2...
April 25, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28425096/influence-of-coral-cover-and-structural-complexity-on-the-accuracy-of-visual-surveys-of-coral-reef-fish-communities
#20
D J Coker, J P Nowicki, N A J Graham
Using manipulated patch reefs with combinations of varying live-coral cover (low, medium and high) and structural complexity (low and high), common community metrics (abundance, diversity, richness and community composition) collected through standard underwater visual census techniques were compared with exhaustive collections using a fish anaesthetic (clove oil). This study showed that reef condition did not influence underwater visual census estimates at a community level, but reef condition can influence the detectability of some small and cryptic species and this may be exacerbated if surveys are conducted on a larger scale...
June 2017: Journal of Fish Biology
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