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https://www.readbyqxmd.com/read/29792467/interdisciplinary-team-science-and-the-public-steps-toward-a-participatory-team-science
#1
Jacob Kraemer Tebes, Nghi D Thai
Interdisciplinary team science involves research collaboration among investigators from different disciplines who work interdependently to share leadership and responsibility. Although over the past several decades there has been an increase in knowledge produced by science teams, the public has not been meaningfully engaged in this process. We argue that contemporary changes in how science is understood and practiced offer an opportunity to reconsider engaging the public as active participants on teams and coin the term participatory team science to describe public engagement in team science...
May 2018: American Psychologist
https://www.readbyqxmd.com/read/29788887/designing-peptidomimetics
#2
Juan J Perez
The concept of a peptidomimetic was coined about forty years ago. Since then, an enormous effort and interest has been devoted to mimic the properties of peptides with small molecules or pseudopeptides. The present report aims to review different approaches described in the past to succeed in this goal. Basically, there are two different approaches to design peptidomimetics: a medicinal chemistry approach, where parts of the peptide are successively replaced by non-peptide moieties until getting a non-peptide molecule and a biophysical approach, where a hypothesis of the bioactive form of the peptide is sketched and peptidomimetics are designed based on hanging the appropriate chemical moieties on diverse scaffolds...
May 21, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29788412/treatment-of-mal-de-debarquement-syndrome-in-a-deployed-environment
#3
Stephanie M Schenk, Jacklyn M Wagner, Jarrod A Miller, Tracey M Lyons-White, Emilee C Venn, Michael D April, Brit Long, Steven G Schauer, Joshua J Oliver
We report the case of a 26-year-old Caucasian female with persistent sensations of forward and reverse movement with spontaneous onset. This worsened over 4 wk. The patient reported an episode of these symptoms 5 mo prior, which lasted for 3 mo before improving. Our case details the treatment of Mal de Debarquement syndrome, or Disembarkment Syndrome, in a deployed military environment. Mal de Debarquement was a term originally coined to describe the persistent sensation of rocking back and forth after disembarking a boat and returning to land...
May 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29787494/-barbell-sign-a-diagnostic-imaging-finding-in-progressive-multifocal-leukoencephalopathy
#4
A Fourie Bezuidenhout, Savvas Andronikou, Christelle Ackermann, Anne-Marie Du Plessis, Derik Basson, Rafeeque A Bhadelia
The recently proposed diagnostic algorithm for progressive multifocal leukoencephalopathy underscores the importance of imaging and emphasizes the role of the radiologist in the diagnostic workup. We describe a case series of patients with visual symptoms and a typical pattern of brain involvement in definite progressive multifocal leukoencephalopathy, for which we have coined the term barbell sign.
May 21, 2018: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29785451/lipidus-migrans-a-radiology-imaging-feature-after-ankle-injury
#5
Malwina Kaniewska, Lynne S Steinbach, Urs Neurauter, Suzanne E Anderson
We present an uncommon imaging feature with fluid fat tracking within the tendon sheath of the flexor hallucis longus (FHL) after traumatic injury to the ankle joint. We propose a coined medical term "lipidus migrans" to define the presence of floating fat in a tendon sheath. This is due to lipohemarthrosis from intra-articular fracture of the ankle with leakage of fluid fat into the tendon sheath. Communication between the FHL tendon sheath and ankle joint can occur in up to 25% of patients. Radiologists should be aware of the presence of lipidus migrans as a potential posttraumatic complication after intra-articular ankle fracture and that fat in the tendon sheath may mimic fracture fragments or even a tendon sheath tumor...
May 21, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29782045/revisiting-the-table-2-fallacy-a-motivating-example-examining-preeclampsia-and-preterm-birth
#6
Gretchen Bandoli, Kristin Palmsten, Christina D Chambers, Laura L Jelliffe-Pawlowski, Rebecca J Baer, Caroline A Thompson
BACKGROUND: A "Table Fallacy," as coined by Westreich and Greenland, reports multiple adjusted effect estimates from a single model. This practice, which remains common in published literature, can be problematic when different types of effect estimates are presented together in a single table. The purpose of this paper is to quantitatively illustrate this potential for misinterpretation with an example estimating the effects of preeclampsia on preterm birth. METHODS: We analysed a retrospective population-based cohort of 2 963 888 singleton births in California between 2007 and 2012...
May 21, 2018: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29781699/conceptualisation-of-african-primal-health-care-within-mental-health-care
#7
Neo E Nare, Abel J Pienaar, Ditaba D Mphuthi
BACKGROUND:  It is believed by western education systems that the first contact should be with the nurse in primary health care. However, it is not the case. Therefore, the researcher attempts to correct this misconception by conceptualising the correct beginning of health seeking behaviour in an indigenous African community, namely African Primal Health Care (APHC). 'Primal' was coined during a colloquium by Dr Mbulawa and Seboka team members; however no formal conceptualisation took place, only operational definition...
March 22, 2018: Curationis
https://www.readbyqxmd.com/read/29779364/swing-door-overlay-tympanoplasty-surgical-technique-and-outcomes
#8
So Young Park, Hyuk Jae Lee, Myung Joo Shim, Dong Kee Kim, Byung Do Suh, Shi Nae Park
Objectives: The classical overlay tympanoplasty is technically difficult with some disadvantages and thus less popular. However, it is particularly useful for large, anterior perforations. In this study, we describe the technique of a modified overlay graft in the tympanoplasty coined as the swing-door overlay tympanoplasty and report its outcomes. Methods: Retrospective review of patients undergoing the swing-door overlay tympanoplasty at a tertiary referral center between 2003 and 2016 was performed...
May 22, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29775275/a-high-performance-and-recyclable-al-air-coin-cell-based-on-eco-friendly-chitosan-hydrogel-membranes
#9
Yisi Liu, Qian Sun, Xiaofei Yang, Jianneng Liang, Biqiong Wang, Alicia Koo, Ruying Li, Jie Li, Xueliang Sun
Aluminum-air batteries are a promising power supply for electronics due to its low cost and high energy density. However, portable coin-type Al-air batteries operating under ambient air condition for small electronic appliances have rarely been reported. Herein, coin cell-type Al-air batteries using cost-effective and eco-friendly chitosan hydrogel membranes modified by SiO2, SnO2, and ZnO have been prepared and assembled. The Al-air coin cell employing chitosan hydrogel membrane containing 10 wt.% SiO2 as a separator exhibits better discharge performance with a higher flat voltage plateau, longer discharge duration, and higher power density than the cells using a chitosan hydrogel membrane containing SnO2 or ZnO...
May 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29771960/the-great-indian-joint-families-of-free-ranging-dogs
#10
Manabi Paul, Anindita Bhadra
Cooperative breeding is an excellent example of cooperation in social groups. Domestic dogs have evolved from cooperatively hunting and breeding ancestors but have adapted to a facultatively social scavenging lifestyle on streets, and solitary living in human homes. Pets typically breed and reproduce under human supervision, but free-ranging dogs can provide insights into the natural breeding ecology of dogs. We conducted a five year-long field based behavioural study on parental care of free-ranging dogs in India...
2018: PloS One
https://www.readbyqxmd.com/read/29771081/-analysis-of-related-factors-of-coins-foreign-bodies-crossing-the-esophagus-in-204-cases-of-children
#11
H L Lv, B Yan, Q H Zhang
Objective: To explore the anti-tumor effect of Stat3 antisense oligodeoxynucleotide on human Hep-2 cell tumor-bearing BALB/c nude mouse, to study the therapeutic value of Stat3 antisense oligodeoxynucleotide on laryngeal cancer. Method: Hep-2 cells from human laryngeal carcinoma in logarithmic phase were inoculated subcutaneously into BALB/c mice to establish a model of human Hep-2 cell tumor-bearing BALB/c mice. They were divided into blank group, control group and different concentrations of AS3 groups(1 group, 2 group, 3 group, 4 group), and then intraperitoneally administered once a day for 4 weeks, measuring body weight twice a week, and the long and short diameters of the tumors were recorded...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29771080/-analysis-of-related-factors-of-coins-foreign-bodies-crossing-the-esophagus-in-204-cases-of-children
#12
M M Ni, L Liu, R Zhao, M Nie, X H Yang
Objective: To evaluate the effect of systemic and intratympanic dexamethasone combination therapy on sudden deafness. Method: A total of 98 patients randomly divided into three groups: an intravenous corticosteroid (systemic corticosteroid monotherapy group); an intratympanic corticosteroid (IT monotherapy group); and a combination therapy group (IT plus systemic combination group). All patients were treated additionally with ginkgo-damole and mecobalamine and proton pomp inhibitor. An audiometry was performed before and after the therapies in all patients...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29771079/-analysis-of-related-factors-of-coins-foreign-bodies-crossing-the-esophagus-in-204-cases-of-children
#13
W B Chen, Z R Zhou, Q Li, X F Shen
Objective: To analyze the related factors of coins crossing the esophagus by themselves in children. Method: Two hundred and four cases with coin esophageal foreign bodies in our hospital from April 2016 to June 2017 were selected,the sex, age, size and texture of foreign body and the time of foreign body insertion were analyzed. Result: Of the 204 children, 46 had esophageal foreign bodies falling off the digestive tract below the esophagus,44 cases were discharged by themselves,2 children were removed under digestive endoscopy,1 coins formed diverticulum at the entrance of esophagus...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29768833/effect-of-dispersoid-on-sulfonium-ionic-liquid-based-gel-polymer-electrolyte-for-lithium-secondary-battery
#14
R Muthupradeepa, M Sivakumar, R Subadevi, V Suryanarayanan, Wei-Ren Liu
The present study emphases on the effect of toting of TiO2 filler on the electrochemical enactment of polymer electrolyte containing PVdF-co-HFP(30) + SEt3TFSI(10) + EC/PC(60) + TiO2(x) wt% (Poly (vinylidene fluoride-co-hexafluoropropylene + Triethylsulfoniumbis(trifluoromethylsulfonyl)imide + Ethylene carbonate/Propylene carbonate (1:1 ratio) + Titanium dioxide) for lithium battery applications. Composite electrolytes with different weight percentages of TiO2 were prepared and characterized by different surface analytical, thermal and electrochemical techniques...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29768297/pediatric-esophageal-foreign-body-possible-role-for-digital-tomosynthesis
#15
Andrew Johansen, Gregory P Conners, Jacob Lee, Amie L Robinson, William L Chew, Sherwin S Chan
OBJECTIVES: Foreign body (FB) ingestion is a common reason for emergency department visits, affecting more than 80,000 children in the United States annually. Whereas most ingested FBs are coins or other radiopaque objects, some are radiolucent FBs such as food. Digital tomosynthesis (DTS) is a radiographic technique that produces cross-sectional images with in-plane resolution similar to that of traditional radiographs. Our pilot study evaluated the sensitivity and specificity of DTS to detect FB in comparison to esophagram and clinical impression...
May 15, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29766023/adeno-associated-virus-genome-population-sequencing-achieves-full-vector-genome-resolution-and-reveals-human-vector-chimeras
#16
Phillip W L Tai, Jun Xie, Kaiyuen Fong, Matthew Seetin, Cheryl Heiner, Qin Su, Michael Weiand, Daniella Wilmot, Maria L Zapp, Guangping Gao
Recombinant adeno-associated virus (rAAV)-based gene therapy has entered a phase of clinical translation and commercialization. Despite this progress, vector integrity following production is often overlooked. Compromised vectors may negatively impact therapeutic efficacy and safety. Using single molecule, real-time (SMRT) sequencing, we can comprehensively profile packaged genomes as a single intact molecule and directly assess vector integrity without extensive preparation. We have exploited this methodology to profile all heterogeneic populations of self-complementary AAV genomes via bioinformatics pipelines and have coined this approach AAV-genome population sequencing (AAV-GPseq)...
June 15, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29764908/management-of-endocrine-disease-which-metabolic-procedure-comparing-outcomes-in-sleeve-gastrectomy-and-roux-en-y-gastric-bypass
#17
Adrian T Billeter, Javier de la Garza Herrera, Katharina M Scheurlen, Felix Nickel, Franck Billmann, Beat Müller-Stich
Obesity and its associated comorbidities have become one of the largest challenges for health care in the near future. Conservative therapy for obesity and related comorbidities have a very high failure rate and poor long-term results. Similarly, the conservative and medical management of the majority of metabolic diseases such as type 2 diabetes mellitus are only able to slow down disease progression but have no causal effect on the disease process. Obesity surgery has evolved as a highly effect therapy for severe obesity achieving long-lasting weight loss...
May 15, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29764688/bridgehead-effects-and-role-of-adaptive-evolution-in-invasive-populations
#18
REVIEW
Cleo Bertelsmeier, Laurent Keller
Biological invasions are a major threat to biodiversity, agriculture, and human health. Invasive populations can be the source of additional new introductions, leading to a self-accelerating process whereby invasion begets invasion. This phenomenon, coined bridgehead effect, has been proposed to stem from the evolution of higher invasiveness in a primary introduced population. There is, however, no conclusive evidence that the success of bridgehead populations stems from the evolution of increased invasiveness...
May 12, 2018: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/29762739/ckd-staging-with-cystatin-c-or-creatinine-based-formulas-flipping-the-coin
#19
Sergio Luis-Lima, Beatriz Escamilla-Cabrera, Natalia Negrín-Mena, Sara Estupiñán, Patricia Delgado-Mallén, Domingo Marrero-Miranda, Ana González-Rinne, Rosa Miquel-Rodríguez, María Ángeles Cobo-Caso, Manuel Hernández-Guerra, Juana Oramas, Norberto Batista, Ana Aldea-Perona, Pablo Jorge-Pérez, Carlos González-Alayón, Miguel Moreno-Sanfiel, Juan Antonio González-Rodríguez, Laura Henríquez, Raquel Alonso-Pescoso, Laura Díaz-Martín, Federico González-Rinne, Bernardo Alio Lavín-Gómez, Judith Galindo-Hernández, Macarena Sánchez-Gallego, Alejandra González-Delgado, Alejandro Jiménez-Sosa, Armando Torres, Esteban Porrini
Background: Chronic kidney disease (CKD) affects 10-13% of the population worldwide. CKD classification stratifies patients in five stages of risk for progressive renal disease based on estimated glomerular filtration rate (eGFR) by formulas and albuminuria. However, the reliability of formulas to reflect real renal function is a matter of debate. The effect of the error of formulas in the CKD classification is unclear, particularly for cystatin C-based equations. Methods: We evaluated the reliability of a large number of cystatin C and/or creatinine-based formulas in the definition of the stages of CKD in 882 subjects with different clinical situations over a wide range of glomerular filtration rates (GFRs) (4...
May 11, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29762181/intraneural-ultrasound-guided-sciatic-nerve-block-minimum-effective-volume-and-electrophysiologic-effects
#20
Gianluca Cappelleri, Andrea Luigi Ambrosoli, Marco Gemma, Valeria Libera Eva Cedrati, Federico Bizzarri, Giorgio Francesco Danelli
BACKGROUND: Both extra- and intraneural sciatic injection resulted in significant axonal nerve damage. This study aimed to establish the minimum effective volume of intraneural ropivacaine 1% for complete sensory-motor sciatic nerve block in 90% of patients, and related electrophysiologic variations. METHODS: Forty-seven consecutive American Society of Anesthesiologists physical status I-II patients received an ultrasound-guided popliteal intraneural nerve block following the up-and-down biased coin design...
May 15, 2018: Anesthesiology
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