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https://www.readbyqxmd.com/read/28429635/congenital-hypothalamic-hamartoblastoma-versus-hamartoma
#1
C Dunham, D McFadden, L Dahlgren, B Butler, S Hamilton, M McKinnon
Pallister Hall syndrome (PHS) is a rare malformative disorder that is due to truncating functional repressor mutations in GLI3. Since the seminal publication in 1980, hypothalamic tumors have been recognized to be a cardinal feature of PHS. In their original description of the neuropathologic features of PHS, Clarren et al. coined the term "hamartoblastoma" to characterize what they deemed to be a dual malformative and neoplastic mass of the hypothalamus. In subsequent published cases/series of PHS, the term "hamartoma" was often substituted for hamartoblastoma given what appeared to be a benign natural history of this lesion...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28427473/intestinal-beh%C3%A3-et-and-crohn-s-disease-two-sides-of-the-same-coin
#2
REVIEW
Simona Valenti, Romina Gallizzi, Dominique De Vivo, Claudio Romano
Behçet's disease (BD) and Crohn's disease (CD) are chronic immune-mediated, inflammatory disorders affecting many different systems (joints, skin, eyes, gastrointestinal and biliary tracts). Both disorders have fluctuating courses and when gastrointestinal symptoms are prevalent, differential diagnosis can be difficult. BD involves the gastrointestinal tract in 10-15% of cases with localized lesions in the ileocecal region. The clinical picture is heterogeneous with various clusters of disease expression. CD is a chronic inflammatory disorder, which can affect any part of the intestinal tract, as well as extra-intestinal tissue...
April 20, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28427092/erratum-pulmonary-embolism-and-atrial-fibrillation-two-sides-of-the-same-coin-a-systematic-review
#3
Behnood Bikdeli, Maen D Abou Ziki, Gregory Y H Lip
No abstract text is available yet for this article.
April 20, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28426986/schr%C3%A3-dinger-s-code-script-not-a-genetic-cipher-but-a-code-of-development
#4
A E Walsby, M J S Hodge
In his book What is Life? Erwin Schrödinger coined the term 'code-script', thought by some to be the first published suggestion of a hereditary code and perhaps a forerunner of the genetic code. The etymology of 'code' suggests three meanings relevant to 'code-script which we distinguish as 'cipher-code', 'word-code' and 'rule-code'. Cipher-codes and word-codes entail translation of one set of characters into another. The genetic code comprises not one but two cipher-codes: the first is the DNA 'base-pairing cipher'; the second is the 'nucleotide-amino-acid cipher', which involves the translation of DNA base sequences into amino-acid sequences...
April 17, 2017: Studies in History and Philosophy of Biological and Biomedical Sciences
https://www.readbyqxmd.com/read/28424579/grp78-at-the-centre-of-the-stage-in-cancer-and-neuroprotection
#5
REVIEW
Caty Casas
The 78-kDa glucose-regulated protein GRP78, also known as BiP and HSP5a, is a multifunctional protein with activities far beyond its well-known role in the unfolded protein response (UPR) which is activated after endoplasmic reticulum (ER) stress in the cells. Most of these newly discovered activities depend on its position within the cell. GRP78 is located mainly in the ER, but it has also been observed in the cytoplasm, the mitochondria, the nucleus, the plasma membrane, and secreted, although it is dedicated mostly to engage endogenous cytoprotective processes...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28423607/cancer-and-neurodegeneration-two-sides-same-coin
#6
EDITORIAL
Sara Garcia-Ratés, Susan Greenfield
No abstract text is available yet for this article.
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418473/diagnosis-of-bacterial-infection-using-a-2-transcript-host-rna-signature-in-febrile-infants-60-days-or-younger
#7
COMMENT
Myrsini Kaforou, Jethro A Herberg, Victoria J Wright, Lachlan J M Coin, Michael Levin
No abstract text is available yet for this article.
April 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28414862/editorial-perspective-longitudinal-research-in-autism-introducing-the-concept-of-chronogeneity
#8
EDITORIAL
Stelios Georgiades, Somer L Bishop, Thomas Frazier
Autism Spectrum Disorder (ASD or autism) is a heterogeneous neurodevelopmental disorder. We are now at a critical juncture in autism research where we have the knowledge base and expertise to begin to think about studies that view heterogeneity, not as 'statistical noise' that can be 'accounted for' using data-reduction techniques (such as group trajectories), but rather as 'informative variance' that can help form a more precise and dynamic picture of autism. In this Editorial we coin a new term and introduce the concept of 'chronogeneity' for the study of autism heterogeneity in relation to the dimension of time (chrono)...
May 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28412675/paired-observation-on-light-cured-composite-resin-and-nano-composite-resin-in-dental-caries-repair
#9
Tao Xiaoling, Muhammad Aqeel Ashraf, Zhao Yanyan
To compare the value of light-cured composite resin with that of nano-composite resin in dental caries repair. 88 patients taking dental caries repair in our hospital from May 2014 to April 2015 were selected, and divided into observation group and control group by coin method with 44 patients in each group. Nano-composite resin was used in observation group, while light-cured composite resin in control group. Then, the occurrence rates of odontohyperesthesia, aesthetic satisfaction with dental caries repair and complications were compared between two groups by visual analogue scale (VAS)...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28411887/from-christian-de-duve-to-yoshinori-ohsumi-more%C3%A2-to-autophagy-than-just-dining-at-home
#10
REVIEW
Margaret M Harnett, Miguel A Pineda, Perle Latré de Laté, Russell J Eason, Sébastien Besteiro, William Harnett, Gordon Langsley
Christian de Duve first coined the expression "autophagy" during his seminal work on the discovery of lysosomes, which led to him being awarded the Nobel Prize in Physiology or Medicine in 1974. The term was adopted to distinguish degradation of intracellular components from the uptake and degradation of extracellular substances that he called "heterophagy". Studies until the 1990s were largely observational/morphological-based until in 1993 Yoshinori Oshumi described a genetic screen in yeast undergoing nitrogen deprivation that led to the isolation of autophagy-defective mutants now better known as ATG (AuTophaGy-related) genes...
February 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28411821/electrochemical-discrimination-of-mints-the-last-chinese-emperors-kuang-hs%C3%A3-and-hs%C3%A3-an-t-ung-monetary-unification
#11
Antonio Doménech-Carbó, María Teresa Doménech-Carbó, Elena Montagna, Carla Álvarez-Romero, Yu Lee
An electrochemical methodology for discriminating monetary emissions, a recurrent problem in much archaeological studies, is introduced. The method is based on the record of voltammetric signatures of cuprite and tenorite corrosion products in the patina using a minimally invasive nanosampling following the voltammetry of immobilized particles methodology. A model for the depth variation of voltammetric electrochemical parameters characterizing the composition of the corrosion patinas is presented. This model permits to rationalize electrochemical data and discriminate different monetary emissions...
July 1, 2017: Talanta
https://www.readbyqxmd.com/read/28411350/acute-appendicitis-somatosensory-disturbances-head-zones-and-the-differential-diagnosis-of-anterior-cutaneous-nerve-entrapment-syndrome-acnes
#12
Rudi M H Roumen, Wouter Vening, Rosanne Wouda, Marc M Scheltinga
BACKGROUND: Anterior cutaneous nerve entrapment syndrome (ACNES) is a neuropathic abdominal wall pain syndrome typically characterized by locally altered skin sensations. On the other hand, visceral disease may also be associated with similar painful and altered skin sensations ("Head zones"). Aim of the study was to determine if patients with acute appendicitis demonstrated somatosensory disturbances in the corresponding right lower quadrant Head zone. METHODS: The presence of somatosensory disturbances such as hyperalgesia, hypoesthesia, altered cool perception, or positive pinch test was determined in 100 patients before and after an appendectomy...
April 14, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28411339/validation-of-a-novel-endoscopic-program-for-measuring-the-size-of-gastrointestinal-lesions
#13
Hyungchul Park, Ji Yong Ahn, Hyungil Seo, Gyu Young Pih, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Jisuk Lee, Jinwoo Jeong, Seon Ok Kim, Jung Bok Lee
BACKGROUND: Valid and reliable methods for measurement of lesion sizes during endoscopy have not been established. METHODS: We developed a novel software program (ENDOVER; Poinbionics, Seoul, Republic of Korea) to measure lesions sizes and assessed its validity and reliability. To validate the program, we measured standard coin sizes and estimated measurement errors. To assess program reliability, 32 pictures of endoscopically resected specimens were used to measure tissue sizes six times in a 24-h interval by two examiners...
April 14, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28409954/direct-probe-of-topological-invariants-using-bloch-oscillating-quantum-walks
#14
V V Ramasesh, E Flurin, M Rudner, I Siddiqi, N Y Yao
The topology of a single-particle band structure plays a fundamental role in understanding a multitude of physical phenomena. Motivated by the connection between quantum walks and such topological band structures, we demonstrate that a simple time-dependent, Bloch-oscillating quantum walk enables the direct measurement of topological invariants. We consider two classes of one-dimensional quantum walks and connect the global phase imprinted on the walker with its refocusing behavior. By disentangling the dynamical and geometric contributions to this phase, we describe a general strategy to measure the topological invariant in these quantum walks...
March 31, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28407017/characterizing-the-anti-inflammatory-and-tissue-protective-actions-of-a-novel-annexin-a1-peptide
#15
Mauro Perretti, Clara Di Filippo, Michele D'Amico, Jesmond Dalli
Inflammation in now appreciated to be at the centre of may diseases that affect Western civilization. Current therapeutics for managing these conditions may interfere with the host response leading to immune suppression. We recently developed an annexin (Anx) A1-derived peptide, coined CR-AnxA12-50, which displays potent pro-resolving and tissue protective actions. Herein, we designed a novel peptide using CR-AnxA12-50 as a template that was significantly more resistant to neutrophil-mediated degradation. This peptide, termed CR-AnxA12-48, retained high affinity and specificity to the pro-resolving Lipoxin A4 receptor (ALX) with an IC50 of ~20nM...
2017: PloS One
https://www.readbyqxmd.com/read/28404155/survival-outcomes-following-laparoscopic-versus-open-d3-dissection-for-stage-ii-or-iii-colon-cancer-jcog0404-a-phase-3-randomised-controlled-trial
#16
Seigo Kitano, Masafumi Inomata, Junki Mizusawa, Hiroshi Katayama, Masahiko Watanabe, Seiichiro Yamamoto, Masaaki Ito, Shuji Saito, Shoichi Fujii, Fumio Konishi, Yoshihisa Saida, Hirotoshi Hasegawa, Tomonori Akagi, Kenichi Sugihara, Takashi Yamaguchi, Tadahiko Masaki, Yosuke Fukunaga, Kohei Murata, Masazumi Okajima, Yoshihiro Moriya, Yasuhiro Shimada
BACKGROUND: Although benefits of laparoscopic surgery compared with open surgery have been suggested, the long-term survival of patients undergoing laparoscopic surgery for colon cancer requiring Japanese D3 dissection remains unclear. We did a randomised controlled trial to establish non-inferiority of laparoscopic surgery to open surgery. METHODS: We did an open-label, multi-institutional, randomised, two-arm phase 3 trial in 30 hospitals in Japan. Patients aged 20-75 years who had histologically proven colon cancer; tumours located in the caecum or ascending, sigmoid, or rectosigmoid colon; T3 or deeper lesions without involvement of other organs, node stages N0-2, and metastasis stage M0; and tumour size of 8 cm or smaller were included...
April 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28401789/psoriasis-and-cardiovascular-disease-two-sides-of-the-same-coin
#17
Michael Doumas, Niki Katsiki, Vasilios Papademetriou
No abstract text is available yet for this article.
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28400420/penny-for-your-thoughts-a-coin-in-the-stomach-why-did-it-get-stuck
#18
Asiya K Shakir, Faridali Ramji, Issam El Halabi
No abstract text is available yet for this article.
April 11, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28398521/the-doctrine-of-original-antigenic-sin-separating-good-from-evil
#19
Arnold S Monto, Ryan E Malosh, Joshua G Petrie, Emily T Martin
The term "Original Antigenic Sin" was coined approximately 60 years ago to describe the imprinting by first influenza type A infection on later antibody response to vaccination. These studies did not suggest reduction in response to current antigens, but instead anamnestic recall of antibody to earlier strains. Then, approximately 40 years ago, it was observed that sequential influenza vaccination might lead to reduced vaccine effectiveness. This conclusion was largely dismissed after an experimental study involving sequential administration of then standard influenza vaccines...
April 7, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28398449/photonics-and-spectroscopy-in-nanojunctions-a-theoretical-insight
#20
REVIEW
Michael Galperin
The progress of experimental techniques at the nanoscale in the last decade made optical measurements in current-carrying nanojunctions a reality, thus indicating the emergence of a new field of research coined optoelectronics. Optical spectroscopy of open nonequilibrium systems is a natural meeting point for (at least) two research areas: nonlinear optical spectroscopy and quantum transport, each with its own theoretical toolbox. We review recent progress in the field comparing theoretical treatments of optical response in nanojunctions as is accepted in nonlinear spectroscopy and quantum transport communities...
April 11, 2017: Chemical Society Reviews
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