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https://www.readbyqxmd.com/read/28925815/examining-the-spatiotemporal-disruption-to-gaze-when-using-a-myoelectric-prosthetic-hand
#1
J V V Parr, S J Vine, N R Harrison, G Wood
The aim of this study was to provide a detailed account of the spatial and temporal disruptions to eye-hand coordination when using a prosthetic hand during a sequential fine motor skill. Twenty-one able-bodied participants performed 15 trials of the picking up coins task derived from the Southampton Hand Assessment Procedure with their anatomic hand and with a prosthesis simulator while wearing eye-tracking equipment. Gaze behavior results revealed that when using the prosthesis, performance detriments were accompanied by significantly greater hand-focused gaze and a significantly longer time to disengage gaze from manipulations to plan upcoming movements...
September 19, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28923231/future-clinical-trials-genetically-driven-trials
#2
REVIEW
Igor Astsaturov
The design of modern oncology clinical trials seeks to match patients' cancer molecular biomarkers with medications that specifically target those biomarkers, a general paradigm shift in cancer care coined clinical cancer biology. This approach exploits the synthetic lethality between a specific genetic alteration in the cancer cell and a drug: rapid termination of exaggerated kinase activity exemplifies this phenomenon. Synthetic lethality-based investigations are driven by rapidly evolving technologies for cancer molecular profiling...
October 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28921595/the-interplay-of-type-i-and-type-ii-interferons-in-murine-autoimmune-cholangitis-as-a-basis-for-sex-biased-autoimmunity
#3
Heekyong R Bae, Deborah L Hodge, Guo-Xiang Yang, Patrick S C Leung, Sathi Babu Chodisetti, Julio C Valencia, Michael Sanford, John M Fenimore, Ziaur S M Rahman, Koichi Tsuneyama, Gary L Norman, M Eric Gershwin, Howard A Young
We have reported a murine model of autoimmune cholangitis, generated by altering the AU rich element by deletion of the IFN-γ 3'UTR region (coined ARE-Del(-/-) ), that has striking similarities to human primary biliary cholangitis (PBC) with female predominance. Previously, we suggested that the gender bias of autoimmune cholangitis was secondary to intense and sustained type I and II IFN signaling. Based on this thesis, and to define the mechanisms that lead to portal inflammation, we specifically addressed the hypothesis that type I IFNs are the driver of this disease...
September 16, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28920499/tactile-radar-experimenting-a-computer-game-with-visually-disabled
#4
Virgínia Kastrup, Alvaro Cassinelli, Paulo Quérette, Niklas Bergstrom, Eliana Sampaio
BACKGROUND: Visually disabled people increasingly use computers in everyday life, thanks to novel assistive technologies better tailored to their cognitive functioning. Like sighted people, many are interested in computer games - videogames and audio-games. Tactile-games are beginning to emerge. The Tactile Radar is a device through which a visually disabled person is able to detect distal obstacles. In this study, it is connected to a computer running a tactile-game. The game consists in finding and collecting randomly arranged coins in a virtual room...
September 18, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28912916/acute-liver-failure-in-a-patient-travelling-from-asia-the-other-face-of-the-coin-of-infectious-disease
#5
Balen Abdulrahman, Mohamed H Ahmed, John Ramage
We present a case of a 63-year-old male who had travelled from South India to United Kingdom (UK) visiting relatives. He had developed episodes of diarrhea, vomiting and fevers while travelling and on assessment in hospital, mild abdominal distension was noted with rapid deterioration to hypovolemic shock. Initial blood test showed a low platelet count with deranged liver function tests (LFTs). It was noted that during admission to intensive care unit (ICU), blood continued to ooze from a previous surgical laparoscopy wound, central and arterial line access sites...
August 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28902615/irregular-analytical-errors-in-diagnostic-testing-a-novel-concept
#6
Michael Vogeser, Christoph Seger
BACKGROUND: In laboratory medicine, routine periodic analyses for internal and external quality control measurements interpreted by statistical methods are mandatory for batch clearance. Data analysis of these process-oriented measurements allows for insight into random analytical variation and systematic calibration bias over time. However, in such a setting, any individual sample is not under individual quality control. The quality control measurements act only at the batch level. Quantitative or qualitative data derived for many effects and interferences associated with an individual diagnostic sample can compromise any analyte...
September 13, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28901162/imagining-autism-feasibility-of-a-drama-based-intervention-on-the-social-communicative-and-imaginative-behaviour-of-children-with-autism
#7
Julie Beadle-Brown, David Wilkinson, Lisa Richardson, Nicola Shaughnessy, Melissa Trimingham, Jennifer Leigh, Beckie Whelton, Julian Himmerich
We report the feasibility of a novel, school-based intervention, coined 'Imagining Autism', in which children with autism engage with drama practitioners though participatory play and improvisation in a themed multi-sensory 'pod' resembling a portable, tent-like structure. A total of 22 children, aged 7-12 years, from three UK schools engaged in the 10-week programme. Measures of social interaction, communication and emotion recognition, along with parent and teacher ratings, were collected before and up to 12 months after the intervention...
September 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28900505/iron-oxide-nanozyme-a-multifunctional-enzyme-mimetic-for-biomedical-applications
#8
REVIEW
Lizeng Gao, Kelong Fan, Xiyun Yan
Iron oxide nanoparticles have been widely used in many important fields due to their excellent nanoscale physical properties, such as magnetism/superparamagnetism. They are usually assumed to be biologically inert in biomedical applications. However, iron oxide nanoparticles were recently found to also possess intrinsic enzyme-like activities, and are now regarded as novel enzyme mimetics. A special term, "Nanozyme", has thus been coined to highlight the intrinsic enzymatic properties of such nanomaterials...
2017: Theranostics
https://www.readbyqxmd.com/read/28899639/prevalence-of-double-diabetes-in-youth-onset-diabetes-patients-from-east-delhi-and-neighboring-ncr-region
#9
B K Mishra, P Shukla, M Aslam, A A Siddiqui, S V Madhu
BACKGROUND: It is being increasingly reported that some of the youth onset diabetes patients cannot be classified clearly as type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) based on usual criteria and the term double diabetes (DD) coined for these cases. AIM: The objective of the study was to find out the prevalence of DD in youth onset diabetes patients from east Delhi and neighboring NCR region. METHODS: A total of 200 patients with youth onset diabetes below 25 years of age were recruited from a tertiary care hospital in East Delhi...
September 9, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28898662/size-dependent-variation-in-plant-form
#10
Karl J Niklas, Edward D Cobb
The study of organic form has a long and distinguished history going at least as far back as Aristotle's Historia Anima¯lium, wherein he identified five basic biological processes that define the forms of animals (metabolism, temperature regulation, information processing, embryo development, and inheritance). Unfortunately, all of Aristotle's writings about plant forms are lost. We know of them only indirectly from his student Theophrastus's companion books, collectively called Historia Plantarum, wherein plant forms are categorized into annual herbs, herbaceous perennials, shrubs, and trees...
September 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28895236/protein-surface-roughness-accounts-for-binding-free-energy-of-plasmepsin-ii-ligand-complexes
#11
Mario E Valdés-Tresanco, Mario S Valdés-Tresanco, Pedro A Valiente, Germinal Cocho, Ricardo Mansilla, J M Nieto-Villar
The calculation of absolute binding affinities for protein-inhibitor complexes remains as one of the main challenges in computational structure-based ligand design. The present work explored the calculations of surface fractal dimension (as a measure of surface roughness) and the relationship with experimental binding free energies of Plasmepsin II complexes. Plasmepsin II is an attractive target for novel therapeutic compounds to treat malaria. However, the structural flexibility of this enzyme is a drawback when searching for specific inhibitors...
September 12, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28894241/an-enhanced-electrochemical-and-cycling-properties-of-novel-boronic-ionic-liquid-based-ternary-gel-polymer-electrolytes-for-rechargeable-li-licoo2-cells
#12
K Karuppasamy, Hyun-Seok Kim, Dongkyu Kim, Dhanasekaran Vikraman, K Prasanna, A Kathalingam, Ramakant Sharma, Hee Woo Rhee
A new generation of boronic ionic liquid namely 1-ethyl-3-methylimidazolium difluoro(oxalate)borate (EMImDFOB) was synthesized by metathesis reaction between 1-ethyl-3-methylimiazolium bromide and lithium difluoro(oxalate)borate (LiDFOB). Ternary gel polymer electrolyte membranes were prepared using electrolyte mixture EMImDFOB/LiDFOB with poly vinylidenefluoride-co-hexafluoropropylene (PVdF-co-HFP) as a host matrix by facile solvent-casting method and plausibly demonstrated its feasibility to use in lithium ion batteries...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893611/emerging-peak-on-the-phylogeographic-landscape-of-mycobacterium-tuberculosis-in-west-asia-definitely-smoke-likely-fire
#13
Igor Mokrousov, Egor Shitikov, Yuriy Skiba, Sergey Kolchenko, Ekaterina Chernyaeva, Anna Vyazovaya
To date, a major attention was justly given to the global lineages of Mycobacterium tuberculosis. Here, we demonstrated an importance of the minor ones, on an example of intriguing and underestimated NEW-1 family that belongs to Euro-American lineage (lineage 4). Analysis of the global WGS/NGS datasets (5715 strains) identified 2235 strains of Lineage 4 and 66 strains of sublineage L4.5. This latter is marked with RD122 genomic deletion and includes NEW-1 family. Phylogenomic analysis confirmed a separate position of the NEW-1 family that we tentatively designate L4...
September 8, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28892500/are-attitudes-toward-peace-and-war-the-two-sides-of-the-same-coin-evidence-to-the-contrary-from-a-french-validation-of-the-attitudes-toward-peace-and-war-scale
#14
Nicolas Van der Linden, Christophe Leys, Olivier Klein, Pierre Bouchat
Bizumic et al. (2013) have recently shown that attitudes towards peace and war reflect two distinct constructs rather than two poles of a single dimension. We present an attempt at validating the French version of their 16-item Attitudes toward Peace and War Scale (APWS) on five distinct (mainly Belgian) French-speaking samples (total N = 808). Confirmatory factor and criterion validity analyses confirmed that attitudes toward peace and war, although negatively related, are distinct in terms of their antecedents and consequences...
2017: PloS One
https://www.readbyqxmd.com/read/28890222/identifying-subsets-of-patients-with-single-level-degenerative-disc-disease-for-lumbar-fusion-the-value-of-prognostic-tests-in-surgical-decision-making
#15
Victor E Staartjes, Pieter-Paul A Vergroesen, Dick J Zeilstra, Marc L Schröder
BACKGROUND CONTEXT: Fusion surgery for degenerative disc disease (DDD) has become a standard of care, albeit not without controversy. Outcomes are inconsistent and a superiority over conservative treatment is debatable. Proper patient selection is key to clinical success, and a comprehensive understanding of prognostic tests does not currently exist. PURPOSE: To investigate the value of prognostic tests and sociodemographic factors in predicting outcomes following lumbar fusion surgery for DDD...
September 7, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28886216/identification-of-1-2-3-dihydro-1h-inden-5-yl-2-ethylamino-pentan-1-one-bk-ivp-in-a-seized-drug-exhibit
#16
Audra Curry Yovanovich, John V Goodpaster, Robert E Minto
To circumvent the law by evading regulation and obscuring their identities in routine analyses, numerous substituted cathinones have entered the illicit drug market. These compounds have been coined "bath salts" by users. In the described case, the laboratory received an unknown white powder for controlled substances identification. The sample could not be immediately identified using standard methods and procedures. Ultimately, the structure was elucidated using GC-MS, NMR, FTIR, GC-SPIR, UV, and color tests to be 1-(2,3-dihydro-1H-inden-5-yl)-2-(ethylamino)pentan-1-one (bk-IVP), a cathinone analog with a rarely observed nonoxygenated bicyclic ring system...
September 8, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28884319/benchmarking-pre-spawning-fitness-climate-preferendum-of-some-catfishes-from-river-ganga-and-its-proposed-utility-in-climate-research
#17
Uttam Kumar Sarkar, Malay Naskar, Koushik Roy, Deepa Sudeeshan, Pankaj Srivastava, Sandipan Gupta, Arun Kumar Bose, Vinod Kumar Verma, Soma Das Sarkar, Gunjan Karnatak, Saurav Kumar Nandy
The concept of threshold condition factor (Fulton), beyond which more than 50% of the female fish population may attain readiness for spawning coined as pre-spawning fitness (K spawn50), has been proposed in the present article and has been estimated by applying the non-parametric Kaplan-Meier method for fitting survival function. A binary coding strategy of gonadal maturity stages was used to classify whether a female fish is "ready to spawn" or not. The proposed K spawn50 has been generated for female Mystus tengara (1...
September 7, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28884169/cloud-engineering-principles-and-technology-enablers-for-medical-image-processing-as-a-service
#18
Shunxing Bao, Andrew J Plassard, Bennett A Landman, Aniruddha Gokhale
Traditional in-house, laboratory-based medical imaging studies use hierarchical data structures (e.g., NFS file stores) or databases (e.g., COINS, XNAT) for storage and retrieval. The resulting performance from these approaches is, however, impeded by standard network switches since they can saturate network bandwidth during transfer from storage to processing nodes for even moderate-sized studies. To that end, a cloud-based "medical image processing-as-a-service" offers promise in utilizing the ecosystem of Apache Hadoop, which is a flexible framework providing distributed, scalable, fault tolerant storage and parallel computational modules, and HBase, which is a NoSQL database built atop Hadoop's distributed file system...
April 2017: Proc IEEE Int Conf Cloud Eng
https://www.readbyqxmd.com/read/28882361/relation-between-parental-psychopathology-and-posttraumatic-growth-after-a-child-s-admission-to-intensive-care-two-faces-of-the-same-coin
#19
Rocío Rodríguez-Rey, Jesús Alonso-Tapia
OBJECTIVES: Confronted with the potentially traumatic experience of a child's admission to a paediatric intensive care unit, parents may experience psychopathological post-trauma symptoms as well as posttraumatic growth. The aim of this cross-sectional study was to explore the relation between psychopathology symptoms, namely, posttraumatic stress disorder), anxiety and depression, as well as post traumatic growth in parents following their child's hospitalisation in a paediatric intensive care unit...
September 4, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28881885/igg4-related-disease-involving-the-esophagus-a-clinicopathological-study
#20
I Obiorah, A Hussain, C Palese, N Azumi, S Benjamin, M Ozdemirli
Immunoglobulin G4 (IgG4)-related disease is a recently coined systemic disease characterized by specific histopathologic findings of an intense lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis in the presence of predominant IgG4-positive plasma cells. Although IgG4-related disease has been described in many organs, involvement of the esophagus is very rare. In this study, we describe the clinicopathologic characteristics of eight patients with IgG4-related esophagitis. We evaluated chronic esophagitis specimens with lymphoplasmacytic infiltrate obtained over the past 6 years (from January 2011 to February 2017) using a chart review, pathologic examination, and IgG4 immunohistochemical staining...
December 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
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