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https://www.readbyqxmd.com/read/28548951/development-of-a-novel-score-for-the-prediction-of-hospital-mortality-in-patients-with-severe-sepsis-the-use-of-electronic-healthcare-records-with-lasso-regression
#1
Zhongheng Zhang, Yucai Hong
BACKGROUND AND OBJECTIVE: There are several disease severity scores being used for the prediction of mortality in critically ill patients. However, none of them was developed and validated specifically for patients with severe sepsis. The present study aimed to develop a novel prediction score for severe sepsis. RESULTS: A total of 3206 patients with severe sepsis were enrolled, including 1054 non-survivors and 2152 survivors. The LASSO score showed the best discrimination (area under curve: 0...
May 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28547211/sheldon-spectrum-and-the-plankton-paradox-two-sides-of-the-same-coin-a-trait-based-plankton-size-spectrum-model
#2
José A Cuesta, Gustav W Delius, Richard Law
The Sheldon spectrum describes a remarkable regularity in aquatic ecosystems: the biomass density as a function of logarithmic body mass is approximately constant over many orders of magnitude. While size-spectrum models have explained this phenomenon for assemblages of multicellular organisms, this paper introduces a species-resolved size-spectrum model to explain the phenomenon in unicellular plankton. A Sheldon spectrum spanning the cell-size range of unicellular plankton necessarily consists of a large number of coexisting species covering a wide range of characteristic sizes...
May 25, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28546543/metabolic-profiling-of-polycystic-ovary-syndrome-reveals-interactions-with-abdominal-obesity
#3
Alexessander Couto Alves, Beatriz Valcarcel, Ville-Petteri Mäkinen, Laure Morin-Papunen, Sylvain Sebert, Antti J Kangas, Pasi Soininen, Shikta Das, Maria De Iorio, Lachlan Coin, Mika Ala-Korpela, Marjo-Riitta Järvelin, Stephen Franks
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with metabolic disturbances including obesity, insulin resistance, and diabetes mellitus. Here we investigate whether changes in the metabolic profile of PCOS women are driven by increased tendency to obesity or are specific features of PCOS related to increased testosterone levels. DESIGN AND METHODS: We conducted an NMR metabolomics association study of PCOS cases (n=145) and controls (n=687) nested in a population-based birth cohort (n=3,127)...
May 26, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28546238/persistent-fetal-lobulation-of-kidney-mimicking-renal-tumour
#4
Syed Muhammad Nazim, Muhibullah Bangash, Basit Salam
Renal pseudotumour is a term coined to describe conditions of renal anatomic variants that simulate focal renal pathology like a tumour on ultrasonography. These include persistent fetal lobulation, hypertrophy of Bertin columns and dromedary humps. We report a case of a 30-year-old nulliparous woman who was managed in gynaecology clinic for menorrhagia and was subsequently referred to us for management of recurrent urinary tract infections. The clinical examination was normal and on ultrasound scan, she was found to have multiple enlarged heterogeneous solid masses in both kidneys with significantly increased vascularity, suspicious for neoplastic lesions...
May 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28545857/different-valsalva-manoeuvre-procedures-for-the-diagnosis-of-right-to-left-shunt-by-contrast-transcranial-doppler
#5
Chao Liu, Teng Lu, Ni-Na Zhai, Ning Bu, Hu-Qing Wang, Meng-Yi Chen, Hai-Qin Wu
The main purpose of this study was to compare two contrast agent injection times during the Valsalva manoeuvre (VM) for the diagnosis of right-to-left shunt using contrast-transcranial Doppler (c-TCD). In total, 992 consecutive patients underwent testing. All patients underwent step 1, and then a coin toss was used to determine the order of steps 2 and 3. The following testing steps were repeated twice: (1) a contrast agent (CA) was infused at rest (CA at rest testing); (2) the VM was initiated immediately after CA injection and released 10 s after CA injection (CA pre-VM testing); and (3) a CA was injected 5 s after initiating the VM, which was released 5 s after CA injection (CA mid-VM testing)...
May 22, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28544040/two-sides-of-the-epstein-barr-virus-ebv-coin-long-term-control-of-ebv-after-liver-transplantation
#6
EDITORIAL
Masaki Yamada, Andrew J Nowalk
No abstract text is available yet for this article.
May 22, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28543877/it-s-time-to-move-on-from-the-bell-curve
#7
Lawrence R Robinson
The bell-curve was first described in the 18(th) century by de Moivre and Gauss to depict the distribution of binomial events, such as coin tossing, or repeated measures of physical objects. In the 19(th) and 20(th) centuries, the bell-curve was appropriated, or perhaps misappropriated, to apply to biologic and social measures across people. For many years we used it to derive reference values for our electrophysiologic studies. There is, however, no reason to believe that electrophysiologic measures should approximate a bell curve distribution, and empiric evidence suggests they do not...
May 23, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28541349/synthesis-of-spiro-quasi-1-catenanes-and-quasi-1-rotaxanes-via-a-templated-backfolding-strategy
#8
Luuk Steemers, Martin J Wanner, Martin Lutz, Henk Hiemstra, Jan H van Maarseveen
Due to their well-defined three-dimensional geometry, spiro compounds are widely utilized in drug research. From the central tetrahedral carbon atom, besides the regular structure, an inverted spiro connectivity may be envisioned. Here we disclose the synthesis of this molecule class that we have coined quasi[1]catenanes. Next to their fascinating and aesthetic shape, the higher compactness as compared to regular spiro bicycles is noteworthy. To enable synthetic access to compact entangled multimacrocyclic molecules, we have developed a new strategy...
May 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28540559/ceramide-and-s1p-signaling-in-embryonic-stem-cell-differentiation
#9
Guanghu Wang, Stefka D Spassieva, Erhard Bieberich
Bioactive sphingolipids are important regulators for stem cell survival and differentiation. Most recently, we have coined the term "morphogenetic lipids" for sphingolipids that regulate stem cells during embryonic and postnatal development. The sphingolipid ceramide and its derivative, sphingosine-1-phosphate (S1P), can act synergistically as well as antagonistically on embryonic stem (ES) cell differentiation. We show here simple as well as state-of-the-art methods to analyze sphingolipids in differentiating ES cells and discuss new protocols to use ceramide and S1P analogs for the guided differentiation of mouse ES cells toward neuronal and glial lineage...
May 25, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28540131/parkinson-s-disease-microglial-macrophage-induced-immunoexcitotoxicity-as-a-central-mechanism-of-neurodegeneration
#10
REVIEW
Russell L Blaylock
Parkinson's disease is one of the several neurodegenerative disorders that affects aging individuals, with approximately 1% of those over the age of 60 years developing the disorder in their lifetime. The disease has the characteristics of a progressive disorder in most people, with a common pattern of pathological change occurring in the nervous system that extends beyond the classical striatal degeneration of dopaminergic neurons. Earlier studies concluded that the disease was a disorder of alpha-synuclein, with the formation of aggregates of abnormal alpha-synuclein being characteristic...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28539902/arousal-in-nocturnal-consciousness-how-dream-and-sleep-experiences-may-inform-us-of-poor-sleep-quality-stress-and-psychopathology
#11
REVIEW
Nirit Soffer-Dudek
The term "sleep experiences," coined by Watson (2001), denotes an array of unusual nocturnal consciousness phenomena; for example, nightmares, vivid or recurrent dreams, hypnagogic hallucinations, dreams of falling or flying, confusional arousals, and lucid dreams. Excluding the latter, these experiences reflect a single factor of atypical oneiric cognitions ("general sleep experiences"). The current study is an opinionated mini-review on the associations of this factor-measured with the Iowa sleep experiences survey (ISES, Watson, 2001)-with psychopathological symptoms and stress...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28539129/double-aortic-arch-presenting-with-a-foreign-object-in-the-oesophagus-a-case-report-and-imaging-diagnosis
#12
Xiuzhen Yang, Jingjing Ye, Zhan Gao
In this article, we report a rare case of double aortic arch. The case presented initially with a foreign object in the oesophagus. The patient was a 2-year-old boy, who was referred with primary symptoms of tussis (15 days) and emesis (2 days). He had a history of ingesting a coin. Routine chest X-ray indicated a rounded, metal foreign object in the upper oesophagus. A half-Yuan coin was removed by gastroduodenoscopy. Echocardiographic imaging suggested that the patient had double aortic arch, which was subsequently diagnosed by CT angiography with three-dimensional reconstruction...
May 25, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28527054/understanding-migraine-as-a-cycling-brain-syndrome-reviewing-the-evidence-from-functional-imaging
#13
Arne May
Due to the clinical picture and also based on early imaging data (Weiller et al. Nat Med 1:658-660, 1995), the brainstem and midbrain structures have been intensely discussed as possible driving or generating structures in migraine. The fact that the brainstem activation persisted after treatment makes it unlikely that this activation was only due to increased activity of the endogenous anti-nociceptive system. It was consequently (and somewhat simplifying) coined the "migraine generator". Since then several studies have focussed on this region when investigating episodic, but also chronic migraine...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28524799/-y-stent-retriever-a-new-rescue-technique-for-refractory-large-vessel-occlusions
#14
Roberto Crosa, Alejandro M Spiotta, Matías Negrotto, Alejandra Jaume, Walter Casagrande
Long-awaited positive trial data have shown the efficacy of endovascular treatment in patients with ischemic stroke who arrive at the hospital within the first 6 hours with large-vessel occlusion of the anterior circulation. With the introduction of stent retrievers (SRs) for mechanical thrombectomy, efficient and safe large-artery recanalization treatment can be achieved. However, sometimes there are patients who do not attain complete flow restoration following attempts with traditional maneuvers. The authors present the case of a 57-year-old man with acute ischemic stroke due to an M1 embolus that extended into both M2 trunks...
May 19, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28524724/antibacterial-effect-of-hydrogen-peroxide-titanium-dioxide-suspensions-in-the-decontamination-of-rough-titanium-surfaces
#15
David Wiedmer, Fernanda Cristina Petersen, Jessica Lönn-Stensrud, Hanna Tiainen
The chemical decontamination of infected dental implants is essential for the successful treatment of peri-implantitis. The aim of this study was to assess the antibacterial effect of a hydrogen peroxide-titanium dioxide (H2O2-TiO2) suspension against Staphylococcus epidermidis biofilms. Titanium (Ti) coins were inoculated with a bioluminescent S. epidermidis strain for 8 h and subsequently exposed to H2O2 with and without TiO2 nanoparticles or chlorhexidine (CHX). Bacterial regrowth, bacterial load and viability after decontamination were analyzed by continuous luminescence monitoring, live/dead staining and scanning electron microscopy...
May 19, 2017: Biofouling
https://www.readbyqxmd.com/read/28523915/wide-temperature-electrolytes-for-lithium-ion-batteries
#16
Qiuyan Li, Shuhong Jiao, Langli Luo, Michael S Ding, Jianming Zheng, Samuel S Cartmell, Chong-Min Wang, Kang Xu, Ji-Guang Zhang, Wu Xu
Formulating electrolytes with solvents of low freezing points and high dielectric constants is a direct approach to extending the service temperature range of lithium (Li)-ion batteries (LIBs). In this work, we report such wide temperature electrolyte formulations by optimizing the content of ethylene carbonate (EC) in the ternary solvent system of EC, propylene carbonate (PC) and ethyl methyl carbonate (EMC) with LiPF6 salt and CsPF6 additive. An extended service temperature range from -40°C to 60°C was obtained in LIBs with lithium nickel cobalt aluminum mixed oxide (LiNi0...
May 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28522311/effect-of-second-timed-appointments-for-non-attenders-of-breast-cancer-screening-in-england-a-randomised-controlled-trial
#17
Prue C Allgood, Roberta Maroni, Sue Hudson, Judith Offman, Anne E Turnbull, Lesley Peacock, Jim Steel, Geraldine Kirby, Christine E Ingram, Julie Somers, Clare Fuller, Anthony G Threlfall, Rhian Gabe, Anthony J Maxwell, Julietta Patnick, Stephen W Duffy
BACKGROUND: In England, participation in breast cancer screening has been decreasing in the past 10 years, approaching the national minimum standard of 70%. Interventions aimed at improving participation need to be investigated and put into practice to stop this downward trend. We assessed the effect on participation of sending invitations for breast screening with a timed appointment to women who did not attend their first offered appointment within the NHS Breast Screening Programme (NHSBSP)...
May 15, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28521866/neovascular-deterioration-impaired-nadph-oxidase-and-inflammatory-cytokine-expression-in-adipose-derived-multipotent-cells-from-subjects-with-metabolic-syndrome
#18
Wilfredo Oliva-Olivera, Said Lhamyani, Leticia Coín-Aragüez, Daniel Castellano-Castillo, Juan Alcaide-Torres, Elena María Yubero-Serrano, Rajaa El Bekay, Francisco José Tinahones
OBJECTIVE: Expansion of adipose tissue depends on the growth of its vascular network and it has been shown that adipose tissue dysfunction in obese subjects with the metabolic syndrome is associated with decreased angiogenesis. However, some subjects with a high body mass index do not develop metabolic abnormalities associated with obesity. In this study we examined the neovascular properties, expression levels of proteins involved in cellular redox balance and inflammatory cytokines in adipose-derived multipotent mesenchymal cells (ASCs) of subjects with different metabolic profiles...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28520211/aging-and-parkinson-s-disease-different-sides-of-the-same-coin
#19
REVIEW
Timothy J Collier, Nicholas M Kanaan, Jeffrey H Kordower
Despite abundant epidemiological evidence in support of aging as the primary risk factor for PD, biological correlates of a connection have been elusive. In this article, we address the following question: does aging represent biology accurately characterized as pre-PD? We present evidence from our work on midbrain dopamine neurons of aging nonhuman primates that demonstrates that markers of known correlates of dopamine neuron degeneration in PD, including impaired proteasome/lysosome function, oxidative/nitrative damage, and inflammation, all increase with advancing age and are exaggerated in the ventral tier substantia nigra dopamine neurons most vulnerable to degeneration in PD...
May 18, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28515288/motor-recovery-beginning-23-years-after-ischemic-stroke
#20
Peter Sörös, Robert Teasell, Daniel F Hanley, J David Spence
It is widely believed that most stroke recovery occurs within 6 months, with little benefit of physiotherapy or other modalities beyond a year. We report a remarkable case of stroke recovery beginning 23 years after a severe stroke due to embolization from the innominate artery and subclavian artery, resulting from compression of the right subclavian artery by a cervical rib. The patient had a large right fronto-parietal infarction with severe left hemiparesis, and a totally non-functional spastic left hand...
May 17, 2017: Journal of Neurophysiology
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