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https://www.readbyqxmd.com/read/29336251/isolating-colchicine-in-19th-century-an-old-drug-revisited
#1
Marianna Karamanou, Gregory Tsoucalas, Konstantinos Pantos, George Androutsos
Colchicine is a tricyclic alkaloid extracted from the herbaceous plant Colchicum autumnale. Known since antiquity for its therapeutic efficacy in the treatment of gout, colchicine was reintroduced in 19th century pharmacopeia, thanks to the work of the French chemists and pharmacists Pierre-Joseph Pelletier (1788-1842) and Joseph Bienaime Caventou (1795-1877) who in 1819, isolated a peculiar substance in the roots of Colchicum autumnale. In 1833, the substance was further analyzed by the German pharmacist and chemist Philipp Lorenz Geiger (1785-1836), who coined the name colchicine...
January 14, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29336158/chromosome-gene-orientations-inversion-networks-goins-of-plasmodium-proteome
#2
Viviana F Quevedo-Tumailli, Bernabe Ortega-Tenezaca, Humbert Gonzalez-Diaz
The spatial distribution of genes in chromosomes seems not to be random. For instance, only 10% of genes are transcribed from bidirectional promoters in humans and many more are organised in larger clusters. This raises intriguing questions asked by different authors before. We would like to add a few more questions in this context, related to gene orientation inversions. Does gene orientation (inversion) follow a random pattern? Is it relevant to biological activity somehow? In this paper, we define a new kind of network coined as the Gene Orientation Inversion Network (GOIN)...
January 16, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29335210/privileged-scaffolds-as-mao-inhibitors-retrospect-and-prospects
#3
REVIEW
Avinash C Tripathi, Savita Upadhyay, Sarvesh Paliwal, Shailendra K Saraf
This review aims to be a comprehensive, authoritative, critical, and readable review of general interest to the medicinal chemistry community because it focuses on the pharmacological, chemical, structural and computational aspects of diverse chemical categories as monoamine oxidase inhibitors (MAOIs). Monoamine oxidases (MAOs), namely MAO-A and MAO-B represent an enormously valuable class of neuronal enzymes embodying neurobiological origin and functions, serving as potential therapeutic target in neuronal pharmacotherapy, and hence we have coined the term "Neurozymes" which is being introduced for the first time ever...
January 4, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29333674/microrna-detection-by-dna-mediated-liposome-fusion
#4
Coline Jumeaux, Olov Wahlsten, Stephan Block, Eunjung Kim, Rona Chandrawati, Philip D Howes, Fredrik Höök, Molly M Stevens
Membrane fusion is a process of fundamental importance in biological systems that involves highly selective recognition mechanisms for the trafficking of molecular and ionic cargos. Mimicking natural membrane fusion mechanisms for the purpose of biosensor development holds great potential for amplified detection because relatively few highly discriminating targets lead to fusion and an accompanied engagement of a large payload of signal-generating molecules. In this work, sequence-specific DNA-mediated liposome fusion is used for the highly selective detection of microRNA...
December 7, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29330469/mycobacterium-tuberculosis-exploits-a-molecular-off-switch-of-the-immune-system-for-intracellular-survival
#5
Ulrich von Both, Maurice Berk, Paul-Michael Agapow, Joseph D Wright, Anna Git, Melissa Shea Hamilton, Greg Goldgof, Nazneen Siddiqui, Evangelos Bellos, Victoria J Wright, Lachlan J Coin, Sandra M Newton, Michael Levin
Mycobacterium tuberculosis (M. tuberculosis) survives and multiplies inside human macrophages by subversion of immune mechanisms. Although these immune evasion strategies are well characterised functionally, the underlying molecular mechanisms are poorly understood. Here we show that during infection of human whole blood with M. tuberculosis, host gene transcriptional suppression, rather than activation, is the predominant response. Spatial, temporal and functional characterisation of repressed genes revealed their involvement in pathogen sensing and phagocytosis, degradation within the phagolysosome and antigen processing and presentation...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330451/tracheophyte-genomes-keep-track-of-the-deep-evolution-of-the-caulimoviridae
#6
Seydina Issa Diop, Andrew D W Geering, Françoise Alfama-Depauw, Mikaël Loaec, Pierre-Yves Teycheney, Florian Maumus
Endogenous viral elements (EVEs) are viral sequences that are integrated in the nuclear genomes of their hosts and are signatures of viral infections that may have occurred millions of years ago. The study of EVEs, coined paleovirology, provides important insights into virus evolution. The Caulimoviridae is the most common group of EVEs in plants, although their presence has often been overlooked in plant genome studies. We have refined methods for the identification of caulimovirid EVEs and interrogated the genomes of a broad diversity of plant taxa, from algae to advanced flowering plants...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29328984/does-college-major-matter-for-women-s-and-men-s-health-in-midlife-examining-the-horizontal-dimensions-of-educational-attainment
#7
Jennifer Karas Montez, Wencheng Zhang, Anna Zajacova, Tod G Hamilton
Studies on how education shapes adult health have largely conceptualized education as the quantity of schooling attained, coined the "vertical dimension" of education. While this dimension is important, heterogeneity within levels of education (the "horizontal dimension") may also shape health. Using data from the 2010-2014 American Community Survey on adults aged 45-64 with a Bachelor's degree (N = 667,362), we investigate the association between a key indicator of adult health (physical functioning) and an understudied horizontal dimension of education (college major)...
January 6, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29324403/performance-of-brain-computer-interfacing-based-on-tactile-selective-sensation-and-motor-imagery
#8
Lin Yao, Xinjun Sheng, Natalie Mrachacz-Kersting, Xiangyang Zhu, Dario Farina, Ning Jiang
A large proportion of users do not achieve adequate control using current non-invasive brain-computer interfaces (BCIs). This issue has being coined "BCI-Illiteracy" and is observed among different BCI modalities. Here, we compare the performance and the BCI-illiteracy rate of a tactile selective sensation (SS) and motor imagery (MI) BCI, for a large subject samples. We analyzed 80 experimental sessions from 57 subjects with two-class SS protocols. For SS, the group average performance was 79.8 ± 10.6%, with 43 out of the 57 subjects (75...
January 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29318509/friend-versus-foe-neural-correlates-of-prosocial-decisions-for-liked-and-disliked-peers
#9
Elisabeth Schreuders, Eduard T Klapwijk, Geert-Jan Will, Berna Güroğlu
Although the majority of our social interactions are with people we know, few studies have investigated the neural correlates of sharing valuable resources with familiar others. Using an ecologically valid research paradigm, this functional magnetic resonance imaging study examined the neural correlates of prosocial and selfish behavior in interactions with real-life friends and disliked peers in young adults. Participants (N = 27) distributed coins between themselves and another person, where they could make selfish choices that maximized their own gains or prosocial choices that maximized outcomes of the other...
January 9, 2018: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29316582/-burnout-in-intensive-care
#10
Andrej Michalsen, Andreas Hillert, Andreas Schießl, Dominik Hinzmann
Both acute crises and chronically incriminating circumstances in people's lives may lead to their being afflicted by psychological and somatic ailments. "Burnout" has been coined and established as the term for chronic occupational strain. Many professions claim to be extraordinarily affected by burnout, amongst others physicians and nurses, especially those working in anaesthesiology and critical care. Usually assessed with the Maslach Burnout Inventary, the prevalence of moderate or severe burnout in these areas is estimated at about 30 % amongst nurses and about 40 % to 50 % amongst physicians...
January 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29315242/nf-kappab-two-sides-of-the-same-coin
#11
REVIEW
Bruno R B Pires, Rafael C M C Silva, Gerson M Ferreira, Eliana Abdelhay
Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number of genes that are involved in important physiological processes, including survival, inflammation, and immune responses. More recently, constitutive expression of NF-κB has been associated with several types of cancer. In addition, microorganisms, such as viruses and bacteria, cooperate in the activation of NF-κB in tumors, confirming the multifactorial role of this transcription factor as a cancer driver. Recent reports have shown that the NF-κB signaling pathway should receive attention for the development of therapies...
January 9, 2018: Genes
https://www.readbyqxmd.com/read/29310751/multi-clonal-evolution-of-multi-drug-resistant-extensively-drug-resistant-mycobacterium-tuberculosis-in-a-high-prevalence-setting-of-papua-new-guinea-for-over-three-decades
#12
Arnold Bainomugisa, Evelyn Lavu, Stenard Hiashiri, Suman Majumdar, Alice Honjepari, Rendi Moke, Paison Dakulala, Grant A Hill-Cawthorne, Sushil Pandey, Ben J Marais, Chris Coulter, Lachlan Coin
An outbreak of multi-drug resistant (MDR) tuberculosis (TB) has been reported on Daru Island, Papua New Guinea. Mycobacterium tuberculosis strains driving this outbreak and the temporal accrual of drug resistance mutations have not been described. Whole genome sequencing of 100 of 165 clinical isolates referred from Daru General Hospital to the Supranational reference laboratory, Brisbane, during 2012-2015 revealed that 95 belonged to a single modern Beijing sub-lineage strain. Molecular dating suggested acquisition of streptomycin and isoniazid resistance in the 1960s, with potentially enhanced virulence mediated by an mycP1 mutation...
January 4, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29310460/stone-compositions-and-different-lithotripters-in-pcnl
#13
Mohammad Hadi Radfar, Behnam Shakiba
We read with great interest the paper by York and colleagues [1] entitled "Randomized controlled trial comparing three different modalities of lithotrites for intracorporeal lithotripsy in PCNL". This study showed that the safety and efficacy of Cyberwand, Lithoclast Select, and the StoneBreaker lithotripters are similar and comparable. They stated that "the clearance rate of "hard" stones (defined as brushite, cystine, and uric acid stones) was comparable across the 3 groups). We would like to point out that this statement is one side of the coin...
January 8, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29310223/portable-vibration-assisted-filtration-device-for-on-site-isolation-of-blood-cells-or-pathogenic-bacteria-from-whole-human-blood
#14
Yong Tae Kim, Kyun Joo Park, Seyl Kim, Soon Ae Kim, Seok Jae Lee, Do Hyun Kim, Tae Jae Lee, Kyoung G Lee
Isolation of specific cells from whole blood is important to monitor disease prognosis and diagnosis. In this study, a vibration-assisted filtration (VF) device has been developed for isolation and recovery of specific cells such as leukocytes and pathogenic bacteria from human whole blood. The VF device is composed of three layers which was fabricated using injection molding with cyclic olefin copolymer (COC) pellets consisting of: a top layer with coin-type vibration motor (Ф = 10mm), a middle plate with a 1μm or 3μm-pore filter membrane to separate of Staphylococcus aureus (S...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29307065/metals-in-bones-of-the-middle-aged-inhabitants-of-sardinia-island-italy-to-assess-nutrition-and-environmental-exposure
#15
Beatrice Bocca, Giovanni Forte, Valentina Giuffra, Rita Maria Serra, Yolande Asara, Cristiano Farace, Marco Milanese, Eugenia Tognotti, Andrea Montella, Pasquale Bandiera, Roberto Madeddu
Metals in bones of 72 subjects lived between the twelfth and eighteenth century AC and collected in four Sardinian (Italian insular region) burial sites (Alghero, Bisarcio, Geridu, and Sassari) were determined and used as biomarkers to evaluate diet and potential social-environmental differences. Concentrations of Ba, Ca, Cd, Cu, Hg, Pb, Sr, and Zn were quantified in different types of compact bone (femur, fibula, humerus, radius, tibia, ulna) by sector field inductively coupled plasma mass spectrometry previous acidic digestion and differences among the various burial sites, centuries, types of bone, gender, and age were explored by univariate and multivariate analyses...
January 6, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29302322/-crowdsourcing-ten-years-in-a-review
#16
Kerri Wazny
Background: First coined by Howe in 2006, the field of crowdsourcing has grown exponentially. Despite its growth and its transcendence across many fields, the definition of crowdsourcing has still not been agreed upon, and examples are poorly indexed in peer-reviewed literature. Many examples of crowdsourcing have not been scaled-up past the pilot phase. In spite of this, crowdsourcing has great potential, especially in global health where resources are lacking. This narrative review seeks to review both indexed and grey crowdsourcing literature broadly in order to explore the current state of the field...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29302143/the-story-of-creation-of-adam-by-the-hands-on-the-vatican-city-coins
#17
Ahmadreza Afshar
No abstract text is available yet for this article.
December 2017: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/29299756/handheld-metal-detector-for-metallic-foreign-body-ingestion-in-pediatric-emergency
#18
Hazwani Binte Hamzah, Vigil James, Suraj Manickam, Sashikumar Ganapathy
OBJECTIVE: Foreign body ingestion is a common problem for which children present to the emergency department. The most common ingested foreign bodies among children are coins. Metal detector is an equipment, which measures a change in inductance of a coil when an electroconductive material is placed near it and produces an audio-visual signal. The present study was conducted to determine the effectiveness and feasibility of HMD in the local Pediatric population. METHODS: This was a prospective study conducted in the pediatric emergency department among children presenting with history of foreign body ingestion...
January 4, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29297669/in-situ-real-time-mechanical-and-morphological-characterization-of-electrodes-for-electrochemical-energy-storage-and-conversion-by-electrochemical-quartz-crystal-microbalance-with-dissipation-monitoring
#19
Netanel Shpigel, Mikhael D Levi, Sergey Sigalov, Leonid Daikhin, Doron Aurbach
Quartz crystal microbalance with dissipation monitoring (QCM-D) generates surface-acoustic waves in quartz crystal plates that can effectively probe the structure of films, particulate composite electrodes of complex geometry rigidly attached to quartz crystal surface on one side and contacting a gas or liquid phase on the other side. The output QCM-D characteristics consist of the resonance frequency (MHz frequency range) and resonance bandwidth measured with extra-ordinary precision of a few tenths of Hz...
January 3, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29290351/red-meat-intake-in-chronic-kidney-disease-patients-two-sides-of-the-coin
#20
REVIEW
Denise Mafra, Natalia A Borges, Ludmila Ferreira Medeiros de Franca Cardozo, Juliana S Anjos, Ana Paula Black, Cristiane Moraes, Peter Bergman, Bengt Lindholm, Peter Stenvinkel
Red meat is an important dietary source of high biological value protein and micronutrients such as vitamins, iron, and zinc that exert many beneficial functions. However, high consumption of animal protein sources, especially red meat, results in an increased intake of saturated fat, cholesterol, iron, and salt, as well as an excessive acid load. Red meat intake may lead to an elevated production of uremic toxins by the gut microbiota, such as trimethylamine n-oxide (TMAO), indoxyl sulfate, and p-cresyl sulfate...
February 2018: Nutrition
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