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electromagnetic cell differentiation

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https://www.readbyqxmd.com/read/29140244/subcellular-analysis-of-pigeon-hair-cells-implicates-vesicular-trafficking-in-cuticulosome-formation-and-maintenance
#1
Simon Nimpf, Erich Pascal Malkemper, Mattias Lauwers, Lyubov Ushakova, Gregory Nordmann, Andrea Wenninger-Weinzierl, Thomas R Burkard, Sonja Jacob, Thomas Heuser, Guenter P Resch, David A Keays
Hair cells are specialized sensors located in the inner ear that enable the transduction of sound, motion, and gravity into neuronal impulses. In birds some hair cells contain an iron-rich organelle, the cuticulosome, that has been implicated in the magnetic sense. Here, we exploit histological, transcriptomic and tomographic methods to investigate the development of cuticulosomes, as well as the molecular and subcellular architecture of cuticulosome positive hair cells. We show that this organelle forms rapidly after hatching in a process that involves vesicle fusion and nucleation of ferritin nanoparticles...
November 15, 2017: ELife
https://www.readbyqxmd.com/read/29109418/extremely-low-frequency-pulsed-electromagnetic-fields-cause-antioxidative-defense-mechanisms-in-human-osteoblasts-via-induction-of-%C3%A2-o2-and-h2o2
#2
Sabrina Ehnert, Anne-Kristin Fentz, Anna Schreiner, Johannes Birk, Benjamin Wilbrand, Patrick Ziegler, Marie K Reumann, Hongbo Wang, Karsten Falldorf, Andreas K Nussler
Recently, we identified a specific extremely low-frequency pulsed electromagnetic field (ELF-PEMF) that supports human osteoblast (hOBs) function in an ERK1/2-dependent manner, suggesting reactive oxygen species (ROS) being key regulators in this process. Thus, this study aimed at investigating how ELF-PEMF exposure can modulate hOBs function via ROS. Our results show that single exposure to ELF-PEMF induced ROS production in hOBs, without reducing intracellular glutathione. Repetitive exposure (>3) to ELF-PEMF however reduced ROS-levels, suggesting alterations in the cells antioxidative stress response...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28990042/hydroxytyrosol-contributes-to-cell-proliferation-and-inhibits-apoptosis-in-pulsed-electromagnetic-fields-treated-human-umbilical-vein-endothelial-cells-in-vitro
#3
Yong Cheng, Zhiwei Qu, Ximeng Fu, Qi Jiang, Jianfeng Fei
A variety of pulsed electromagnetic fields (PEMFs) have been experimentally and clinically used in an effort to promote wound healing, although the mechanisms involved remain unknown. The aim of the present study was to investigate the action of a novel protocol of co‑treatment with PEMFs and hydroxytyrosol (HTY) on the proliferation and differentiation potential of human umbilical vein endothelial cells (HUVECs). The HUVECs were assigned randomly into three groups: Control, PEMF‑treated and PEMF + HT‑treated...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28965919/pulsed-electromagnetic-fields-inhibit-human-osteoclast-formation-and-gene-expression-via-osteoblasts
#4
Zhiming He, Nagarajan Selvamurugan, Johanna Warshaw, Nicola C Partridge
Pulsed electromagnetic fields (PEMFs) can be effective in promoting the healing of delayed union or nonunion fractures. We previously reported that PEMF (Spinal-Stim® by Orthofix, Inc., Lewisville, TX) stimulated proliferation, differentiation and mineralization of rat calvarial osteoblastic cells in culture. In the present work we investigated the effects of PEMF (Physio-Stim® by Orthofix, Inc., Lewisville, TX) on human bone marrow macrophages (hBMMs) differentiated to osteoclasts. PEMF had striking inhibitory effects on formation of osteoclasts from hBMMs from both younger and older women...
September 28, 2017: Bone
https://www.readbyqxmd.com/read/28932245/electromagnetic-fields-for-the-regulation-of-neural-stem-cells
#5
REVIEW
Mengchu Cui, Hongfei Ge, Hengli Zhao, Yongjie Zou, Yujie Chen, Hua Feng
Localized magnetic fields (MFs) could easily penetrate the scalp, skull, and meninges, thus inducing an electrical current in both the central and peripheral nervous systems, which is primarily used in transcranial magnetic stimulation (TMS) for inducing specific effects on different regions or cells that play roles in various brain activities. Studies of repetitive transcranial magnetic stimulation (rTMS) have led to novel attractive therapeutic approaches. Neural stem cells (NSCs) in adult human brain are able to self-renew and possess multidifferential ability to maintain homeostasis and repair damage after acute central nervous system...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28910516/controlling-differentiation-of-stem-cells-for-developing-personalized-organ-on-chip-platforms
#6
REVIEW
Armin Geraili, Parya Jafari, Mohsen Sheikh Hassani, Behnaz Heidary Araghi, Mohammad Hossein Mohammadi, Amir Mohammad Ghafari, Sara Hasanpour Tamrin, Hassan Pezeshgi Modarres, Ahmad Rezaei Kolahchi, Samad Ahadian, Amir Sanati-Nezhad
Organ-on-chip (OOC) platforms have attracted attentions of pharmaceutical companies as powerful tools for screening of existing drugs and development of new drug candidates. OOCs have primarily used human cell lines or primary cells to develop biomimetic tissue models. However, the ability of human stem cells in unlimited self-renewal and differentiation into multiple lineages has made them attractive for OOCs. The microfluidic technology has enabled precise control of stem cell differentiation using soluble factors, biophysical cues, and electromagnetic signals...
September 14, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28843440/the-expression-of-pluripotency-and-neuronal-differentiation-markers-under-the-influence-of-electromagnetic-field-and-nitric-oxide
#7
Nazanin Haghighat, Parviz Abdolmaleki, Javad Parnian, Mehrdad Behmanesh
Nitric oxide (NO) is a diatomic free radical compound that as a secondary messenger contributes to cell physiological functions and its variations influence proteins activity and triggering intracellular signaling cascades. Low frequency electromagnetic field (EMF) alters the cell biology such as cell differentiation by targeting the plasma membrane and entering force to the ions and small electrical ligands. The effect of these chemical (NO) and physical (EMF) factors on the expression of the stemness and neuronal differentiation markers in rat bone marrow mesenchymal stem cells (BMSC) was investigated...
August 24, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28842627/enhancement-of-mesenchymal-stem-cell-chondrogenesis-with-short-term-low-intensity-pulsed-electromagnetic-fields
#8
Dinesh Parate, Alfredo Franco-Obregón, Jürg Fröhlich, Christian Beyer, Azlina A Abbas, Tunku Kamarul, James H P Hui, Zheng Yang
Pulse electromagnetic fields (PEMFs) have been shown to recruit calcium-signaling cascades common to chondrogenesis. Here we document the effects of specified PEMF parameters over mesenchymal stem cells (MSC) chondrogenic differentiation. MSCs undergoing chondrogenesis are preferentially responsive to an electromagnetic efficacy window defined by field amplitude, duration and frequency of exposure. Contrary to conventional practice of administering prolonged and repetitive exposures to PEMFs, optimal chondrogenic outcome is achieved in response to brief (10 minutes), low intensity (2 mT) exposure to 6 ms bursts of magnetic pulses, at 15 Hz, administered only once at the onset of chondrogenic induction...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28833306/pulsed-electromagnetic-fields-promote-the-proliferation-and-differentiation-of-osteoblasts-by-reinforcing-intracellular-calcium-transients
#9
Jie Tong, Lijun Sun, Bin Zhu, Yun Fan, Xingfeng Ma, Liyin Yu, Jianbao Zhang
Pulsed electromagnetic fields (PEMF) can be used to treat bone-related diseases, but the underlying mechanism remains unclear, especially the process by which PEMFs initiate biological effects. In this study, we demonstrated the effects of PEMF on proliferation and differentiation of osteoblasts using the model of calcium transients induced by high extracellular calcium. Our results showed that PEMF can increase both the percentage of responding cells and amplitude of intracellular calcium transients induced by high extracellular calcium stimulation...
October 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28815594/differential-effects-of-changes-in-spectral-irradiance-on-photoacclimation-primary-productivity-and-growth-in-rhodomonas-salina-cryptophyceae-and-skeletonema-costatum-bacillariophyceae-in-simulated-blackwater-environments
#10
Evelyn Lawrenz, Tammi L Richardson
The underwater light field in blackwater environments is strongly skewed toward the red end of the electromagnetic spectrum due to blue light absorption by colored dissolved organic matter (CDOM). Exposure of phytoplankton to full spectrum irradiance occurs only when cells are mixed up to the surface. We studied the potential effects of mixing-induced changes in spectral irradiance on photoacclimation, primary productivity and growth in cultures of the cryptophyte Rhodomonas salina and the diatom Skeletonema costatum...
August 16, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28782873/stable-morphological-physiological-and-neural-protein-expression-changes-in-rat-bone-marrow-mesenchymal-stem-cells-treated-with-electromagnetic-field-and-nitric-oxide
#11
Nazanin Haghighat, Parviz Abdolmaleki, Mehrdad Behmanesh, Mohammad Satari
As an external physical factor, electromagnetic field (EMF) may influence cellular processes and nitric oxide (NO) by serving as a secondary messenger molecule in intracellular signaling cascades. Effects of these factors were evaluated simultaneously on viability, morphology, and variation of calcium ion content, and neural protein marker expression in rat bone marrow mesenchymal stem cells (BMSCs). The mesenchymal stem cells were isolated from rat bone marrow and cultured. Deta-NO as a donor molecule of NO was added to cell culture medium after several passages...
December 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28746081/synergism-of-electrospun-nanofibers-and-pulsed-electromagnetic-field-on-osteogenic-differentiation-of-induced-pluripotent-stem-cells
#12
Abdolreza Ardeshirylajimi, Arash Khojasteh
According to the current therapies failure for bone fractures and lesions, tissue engineering showed a great potential to help solve these challenges. Because the use of growth factors is very limited in the clinic, it could be very useful that could be introducing an alternative to it. Extremely low frequency pulsed electromagnetic fields (PEMF, 1 mT, 50 Hz) were used for achieving this aim. The PEMF potential in combination with electrospun polycaprolactone (PCL) nanofibers was used to investigate the osteogenic potential of human induced pluripotent stem cells (iPSCs)...
July 25, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28741320/differential-intensity-dependent-effects-of-pulsed-electromagnetic-fields-on-rankl-induced-osteoclast-formation-apoptosis-and-bone-resorbing-ability-in-raw264-7-cells
#13
Pan Wang, Juan Liu, Yuefan Yang, Mingming Zhai, Xi Shao, Zedong Yan, Xuhui Zhang, Yan Wu, Lu Cao, Bingdong Sui, Erping Luo, Da Jing
Pulsed electromagnetic fields (PEMF) have been proven to be effective for promoting bone mass and regulating bone turnover both experimentally and clinically. However, the exact mechanisms for the regulation of PEMF on osteoclastogenesis as well as optical exposure parameters of PEMF on inhibiting osteoclastic activities and functions remain unclear, representing significant limitations for extensive scientific application of PEMF in clinics. In this study, RAW264.7 cells incubated with RANKL were exposed to 15 Hz PEMF (2 h/day) at various intensities (0...
December 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28715443/far-infrared-radiation-promotes-rabbit-renal-proximal-tubule-cell-proliferation-and-functional-characteristics-and-protects-against-cisplatin-induced-nephrotoxicity
#14
I-Ni Chiang, Yeong-Shiau Pu, Chao-Yuan Huang, Tai-Horng Young
Far infrared radiation, a subdivision of the electromagnetic spectrum, is beneficial for long-term tissue healing, anti-inflammatory effects, growth promotion, sleep modulation, acceleration of microcirculation, and pain relief. We investigated if far infrared radiation is beneficial for renal proximal tubule cell cultivation and renal tissue engineering. We observed the effects of far infrared radiation on renal proximal tubules cells, including its effects on cell proliferation, gene and protein expression, and viability...
2017: PloS One
https://www.readbyqxmd.com/read/28713615/effects-of-radiofrequency-exposure-emitted-from-a-gsm-mobile-phone-on-proliferation-differentiation-and-apoptosis-of-neural-stem-cells
#15
Mahsa Eghlidospour, Amir Ghanbari, Seyyed Mohammad Javad Mortazavi, Hassan Azari
Due to the importance of neural stem cells (NSCs) in plasticity of the nervous system and treating neurodegenerative diseases, the main goal of this study was to evaluate the effects of radiofrequency radiation emitted from a GSM 900-MHz mobile phone with different exposure duration on proliferation, differentiation and apoptosis of adult murine NSCs in vitro. We used neurosphere assay to evaluate NSCs proliferation, and immunofluorescence assay of neural cell markers to examine NSCs differentiation. We also employed alamarBlue and caspase 3 apoptosis assays to assess harmful effects of mobile phone on NSCs...
June 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/28607928/extremely-low-frequency-electromagnetic-fields-affect-myogenic-processes-in-c2c12-myoblasts-role-of-gap-junction-mediated-intercellular-communication
#16
Caterina Morabito, Nathalie Steimberg, Francesca Rovetta, Jennifer Boniotti, Simone Guarnieri, Giovanna Mazzoleni, Maria A Mariggiò
Extremely low-frequency electromagnetic fields (ELF-EMFs) can interact with biological systems. Although they are successfully used as therapeutic agents in physiatrics and rehabilitative practice, they might represent environmental pollutants and pose a risk to human health. Due to the lack of evidence of their mechanism of action, the effects of ELF-EMFs on differentiation processes in skeletal muscle were investigated. C2C12 myoblasts were exposed to ELF-EMFs generated by a solenoid. The effects of ELF-EMFs on cell viability and on growth and differentiation rates were studied using colorimetric and vital dye assays, cytomorphology, and molecular analysis of MyoD and myogenin expression, respectively...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28595038/bio-electric-field-enhancement-the-influence-on-hyaluronan-mediated-motility-receptors-in-human-breast-carcinoma
#17
Marcy C Purnell
Mechanisms that regulate cancer cell metastasis are often intricately linked to mechanisms that control cell migration in wound repair. Hyaluronan Mediated Motility Receptor (HMMR) encodes a receptor for hyaluronan-mediated motility (RHAMM), a non-integral cell surface hyaluronan receptor and intracellular protein that promotes mitotic spindle formation and cell motility. RHAMM has been found to have increased expression in both cancers and wounds, and when cancers show increased RHAMM expression poor outcomes have occurred...
April 2017: Discovery Medicine
https://www.readbyqxmd.com/read/28594366/rf-emf-risk-perception-revisited-is-the-focus-on-concern-sufficient-for-risk-perception-studies
#18
Peter M Wiedemann, Frederik Freudenstein, Christoph Böhmert, Joe Wiart, Rodney J Croft
An implicit assumption of risk perception studies is that concerns expressed in questionnaires reflect concerns in everyday life. The aim of the present study is to check this assumption, i.e., the extrapolability of risk perceptions expressed in a survey, to risk perceptions in everyday life. To that end, risk perceptions were measured by a multidimensional approach. In addition to the traditional focus on measuring the magnitude of risk perceptions, the thematic relevance (how often people think about a risk issue) and the discursive relevance (how often people think about or discuss a risk issue) of risk perceptions were also collected...
June 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28579894/osteogenic-differentiation-of-bone-marrow-mesenchymal-stem-cells-by-magnetic-nanoparticle-composite-scaffolds-under-a-pulsed-electromagnetic-field
#19
Jianghong Huang, Daming Wang, Jielin Chen, Wei Liu, Li Duan, Wei You, Weimin Zhu, Jianyi Xiong, Daping Wang
This study was conducted to investigate the effect of magnetic nanoparticle composite scaffold under a pulsed electromagnetic field on bone marrow mesenchymal stem cells (BMSCs), which was achieved by examining the biological behaviors of cell adhesion, proliferation and differentiation on the surface of the scaffolds. This may provide some experimental evidence for the use of magnetic nanoparticles in medical application. The magnetic nanoparticle composite scaffolds were evaluated and characterized by the following indexes: the cell proliferation was detected by the CCK-8 method, the alkaline phosphatase (ALP) activity was examined by a detection kit, and the expression of type I collagen and osteocalcin gene were evaluated by RT-PCR...
May 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28512472/pulsed-electromagnetic-field-regulates-microrna-21-expression-to-activate-tgf-%C3%AE-signaling-in-human-bone-marrow-stromal-cells-to-enhance-osteoblast-differentiation
#20
Nagarajan Selvamurugan, Zhiming He, Daniel Rifkin, Branka Dabovic, Nicola C Partridge
Pulsed electromagnetic fields (PEMFs) have been documented to promote bone fracture healing in nonunions and increase lumbar spinal fusion rates. However, the molecular mechanisms by which PEMF stimulates differentiation of human bone marrow stromal cells (hBMSCs) into osteoblasts are not well understood. In this study the PEMF effects on hBMSCs were studied by microarray analysis. PEMF stimulation of hBMSCs' cell numbers mainly affected genes of cell cycle regulation, cell structure, and growth receptors or kinase pathways...
2017: Stem Cells International
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