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https://www.readbyqxmd.com/read/29164482/molecular-imaging-in-musculoskeletal-infections-with-99m-tc-ubi-29-41-spect-ct
#1
Mike Sathekge, Osvaldo Garcia-Perez, Diana Paez, Noura El-Haj, Taylor Kain-Godoy, Ismaheel Lawal, Enrique Estrada-Lobato
OBJECTIVE: To determine the added value of CT over planar and SPECT-only imaging in the diagnosis of musculoskeletal infection using (99m)Tc-UBI 29-4. MATERIALS AND METHODS: 184 patients with suspected musculoskeletal infection who underwent planar and SPECT/CT imaging with (99m)Tc-UBI 29-41 were included. Planar, SPECT-only and SPECT/CT images were reviewed by two independent analysts for presence of bone or soft tissue infection. Final diagnosis was confirmed with tissue cultures, surgery/histology or clinical follow-up...
November 21, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29150470/platelet-rich-plasma-in-achilles-tendon-healing-2-path-2-trial-protocol-for-a-multicentre-participant-and-assessor-blinded-parallel-group-randomised-clinical-trial-comparing-platelet-rich-plasma-prp-injection-versus-placebo-injection-for-achilles-tendon-rupture
#2
Joseph Alsousou, David J Keene, Philippa A Hulley, Paul Harrison, Susan Wagland, Christopher Byrne, Michael Maia Schlüssel, Susan J Dutton, Sarah E Lamb, Keith Willett
BACKGROUND: Achilles tendon injuries give rise to substantial long-lasting morbidity and pose considerable challenges for clinicians and patients during the lengthy healing period. Current treatment strategies struggle to curb the burden of this injury on health systems and society due to lengthy rehabilitation, work absence and reinjury risk. Platelet-rich plasma (PRP) is an autologous preparation that has been shown to improve the mechanobiological properties of tendons in laboratory and animal studies...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29137644/functional-resonance-magnetic-imaging-fmri-in-adolescents-with-idiopathic-musculoskeletal-pain-a-paradigm-of-experimental-pain
#3
Juliana Molina, Edson Amaro, Liana Guerra Sanches da Rocha, Liliana Jorge, Flavia Heloisa Santos, Claudio A Len
BACKGROUND: Studies on functional magnetic resonance imaging (fMRI) have shown that adults with musculoskeletal pain syndromes tolerate smaller amount of pressure (pain) as well as differences in brain activation patterns in areas related to pain.The objective of this study was to evaluate, through fMRI, the brain activation in adolescents with idiopathic musculoskeletal pain (IMP) while performing an experimental paradigm of pain. METHODS: The study included 10 consecutive adolescents with idiopathic musculoskeletal pain (average age 16...
November 14, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29137025/tapentadol-versus-tramadol-in-the-management-of-low-back-pain-in-the-emergency-department-impact-of-use-on-the-need-for-reassessments
#4
Carlos A Guillén-Astete, César Cardona-Carballo, Cristina de la Casa-Resino
Nontraumatic musculoskeletal disorders are the main reason for presentation to the emergency department (ED), with rachialgia (back pain) being the most common reason to request medical assessment among them. This also generates the highest demand for reassessments due to poor pain control or onset of adverse reactions to the treatment prescribed in the initial assessment.A retrospective observational study based on usual clinical practice was conducted in patients attending the ED due to low back pain during a period of 24 months...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136387/randomized-multicenter-placebo-controlled-clinical-trial-of-duloxetine-versus-placebo-for-aromatase-inhibitor-associated-arthralgias-in-early-stage-breast-cancer-swog-s1202
#5
N Lynn Henry, Joseph M Unger, Anne F Schott, Louis Fehrenbacher, Patrick J Flynn, Debra M Prow, Carl W Sharer, Gary V Burton, Charles S Kuzma, Anna Moseley, Danika L Lew, Michael J Fisch, Carol M Moinpour, Dawn L Hershman, James L Wade
Purpose Adherence to aromatase inhibitor (AI) therapy for early-stage breast cancer is limited by AI-associated musculoskeletal symptoms (AIMSS). Duloxetine is US Food and Drug Administration approved for treatment of multiple chronic pain disorders. We hypothesized that treatment of AIMSS with duloxetine would improve average joint pain compared with placebo. Methods This randomized, double-blind, phase III trial included AI-treated postmenopausal women with early-stage breast cancer and who had average joint pain score of ≥ 4 out of 10 that developed or worsened since AI therapy initiation...
November 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29128193/vitamin-d-levels-vitamin-d-receptor-polymorphisms-and-inflammatory-cytokines-in-aromatase-inhibitor-induced-arthralgias-an-analysis-of-cctg-ma-27
#6
Polly Niravath, Bingshu Chen, Judy-Anne W Chapman, Sandeep K Agarwal, Robert L Welschhans, Tim Bongartz, Krishna R Kalari, Lois E Shepherd, John Bartlett, Kathleen Pritchard, Karen Gelmon, Susan G Hilsenbeck, Mothaffar F Rimawi, C Kent Osborne, Paul E Goss, James N Ingle
BACKGROUND: Approximately half of women taking aromatase inhibitor (AI) therapy develop AI-induced arthralgia (AIA), and many might discontinue AI therapy because of the pain. Using plasma samples from the MA.27 study, we assessed several factors potentially associated with AIA. PATIENTS AND METHODS: MA.27 is a phase III adjuvant trial comparing 2 AIs, exemestane versus anastrozole. Within an 893-participant nested case-control AIA genome-wide association study, we nested a 72 AIA case-144 control assessment of vitamin D plasma concentrations, corrected for seasonal and geographic variation...
October 16, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29113678/a-large-single-institution-review-of-tracheoesophageal-fistulae-with-evaluation-of-the-use-of-transanastomotic-feeding-tubes
#7
Joseph C Fusco, Juan L Calisto, Barbara A Gaines, Marcus M Malek
INTRODUCTION: Transanastomatic feeding tube (TAT) use in the repair of tracheoesophageal fistulas (TEF) with or without esophageal atresia (EA) and EA with or without TEF allows for earlier enteral feedings, however, may predispose to esophageal stricture. METHODS: We review our institutional experience with esophageal atresia repair over a 15-year period from 2000 to 2015 and report on our observed complication rate with emphasis on the surgical approach and use of TATs...
October 10, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29091995/safety-and-efficacy-of-alternating-treatment-with-ep2006-a-filgrastim-biosimilar-and-reference-filgrastim-a-phase-3-randomised-double-blind-clinical-study-in-the-prevention-of-severe-neutropenia-in-patients-with-breast-cancer-receiving-myelosuppressive-chemotherapy
#8
K Blackwell, P Gascon, A Krendyukov, S Gattu, Y Li, N Harbeck
Background: In 2015, the biosimilar filgrastim EP2006 became the first biosimilar approved by the US Food and Drug Administration (FDA) for commercial use in the United States, marketed as Zarxio®. This phase 3 randomised, double-blind registration study in patients with breast cancer receiving (neo)adjuvant myelosuppressive chemotherapy (TAC; docetaxel+doxorubicin+cyclophosphamide) compares reference filgrastim, Neupogen®, with two groups receiving alternating treatment with reference and biosimilar every other cycle...
October 28, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29052757/variation-in-occupational-exposure-associated-with-musculoskeletal-complaints-a-cross-sectional-study-among-professional-bassists
#9
Kees H Woldendorp, Anne M Boonstra, J Hans Arendzen, Michiel F Reneman
BACKGROUND: Variation in occupational exposure is assumed to have a protective effect against the development of musculoskeletal complaints (MSC), but this common assumption is not strongly supported by the literature. Among musicians, who have a high prevalence of MSC, many play more than one type of instrument (multi-instrumentalism) for many hours a day. Since multi-instrumentalism implies greater variation in ergonomic load of specific musculoskeletal areas than mono-instrumentalism, musicians are a suitable study population to test whether the above assumption is true...
October 20, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29028358/posterior-tibial-translation-measurements-on-magnetic-resonance-imaging-improve-diagnostic-sensitivity-for-chronic-posterior-cruciate-ligament-injuries-and-graft-tears
#10
Nicholas N DePhillipo, Mark E Cinque, Jonathan A Godin, Gilbert Moatshe, Jorge Chahla, Robert F LaPrade
BACKGROUND: Magnetic resonance imaging (MRI) of the knee is a highly sensitive and specific method for diagnosing acute posterior cruciate ligament (PCL) tears, with a reported accuracy of 96% to 100%. In chronic and revision settings, these injuries may be missed on MRI because of the apparent continuity of nonfunctional PCL fibers. Posterior tibial translation (PTT) of the medial compartment has been identified as a potential secondary finding of PCL tear on routine MRI. Purpose/Hypothesis: The purpose of this study was to evaluate the sensitivity of PTT on MRI associated with PCL injuries and compare it with the sensitivity of a radiologist's MRI interpretation with preoperative posterior knee stress radiographs as the gold standard...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28992772/hip-abductor-muscle-volume-and-strength-differences-between-women-with-chronic-hip-joint-pain-and-asymptomatic-controls
#11
Matthew J Mastenbrook, Paul K Commean, Travis J Hillen, Gretchen B Salsich, Gretchen A Meyer, Michael J Mueller, John C Clohisy, Marcie Harris-Hayes
Study Design Secondary analysis, cross-sectional study. Background Chronic hip joint pain (CHJP) can lead to limitations in activity participation, but the musculoskeletal factors associated with the condition are relatively unknown. Understanding the factors associated with CHJP may help develop rehabilitation strategies to improve quality of life of individuals with long-term hip pain. Objectives To compare measures of hip abductor muscle volume and hip abductor muscle strength between women with CHJP and asymptomatic controls...
October 9, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28988692/the-survey-on-cellular-and-tissue-engineered-therapies-in-europe-and-neighboring-eurasian-countries-in-2014-and-2015
#12
Hilary Ireland, Max H P Gay, Helen Baldomero, Barbara De Angelis, Hossein Baharvand, Mark W Lowdell, Jakob Passweg, Ivan Martin
BACKGROUND AIMS: With the support of five established scientific organizations, this report, the seventh of its kind, describes activity in Europe for the years 2014 and 2015 in the area of cellular and tissue-engineered therapies, excluding hematopoietic stem cell (HSC) treatments for the reconstitution of hematopoiesis. METHODS: In 2015 [respectively 2014], 205 [276] teams from 32 countries responded to the cellular and tissue-engineered therapy survey; 178 [126] teams reported treating 3686 [2665] patients...
October 4, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28986742/treatment-strategies-for-central-low-grade-chondrosarcoma-of-long-bones-a-systematic-review-of-the-literature-and-meta-analysis
#13
REVIEW
S S Shemesh, J D Acevedo-Nieves, J Pretell-Mazzini
The need for wide local excision (WLE) versus intralesional (IL) treatment of low-grade chondrosarcomas (CS) of the appendicular skeleton remains controversial. We sought to perform a systematic review and meta-analysis to compare different conventional types of surgical treatments for grade I CS in terms of: (1) rate of local recurrence (LR) and metastases, (2) functional outcome as measured by the Musculoskeletal Tumor Society (MSTS) score, (3) complication rate. Eighteen studies enrolling 695 patients met our criteria...
October 6, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28976423/effectiveness-and-costs-of-a-vocational-advice-service-to-improve-work-outcomes-in-patients-with-musculoskeletal-pain-in-primary-care-a-cluster-randomised-trial-swap-trial-isrctn-52269669
#14
Gwenllian Wynne-Jones, Majid Artus, Annette Bishop, Sarah A Lawton, Martyn Lewis, Sue Jowett, Jesse Kigozi, Chris Main, Gail Sowden, Simon Wathall, A Kim Burton, Danielle A van der Windt, Elaine M Hay, Nadine E Foster
Musculoskeletal pain is a common cause of work absence and early intervention is advocated to prevent the adverse health and economic consequences of longer-term absence. This cluster randomised controlled trial investigated the effect of introducing a vocational advice service, into primary care to provide occupational support. Six general practices were randomised, patients were eligible if they were consulting their general practitioner (GP) with musculoskeletal pain, were employed and struggling at work or absent from work <6 months...
September 30, 2017: Pain
https://www.readbyqxmd.com/read/28972793/potential-discrepancy-between-plain-films-and-ct-scans-in-brooker-classification-of-heterotopic-ossification
#15
Tao Mary Jiayi, Probyn Linda, Poon Michael, Kreder Hans, Nousiainen Markku, Jenkinson Richard, Wan Bo Angela, Tsao May, Barnes Elizabeth, Chow Edward
OBJECTIVES: The Brooker classification is a commonly used tool to characterize the extent of heterotopic ossification (HTO), which is the dystrophic formation of mature lamellar bone in non-osseous tissues such as muscles, connective tissue or nerves. We aim to provide illustrative cases to describe the limitations and challenges of this system. METHODS: A retrospective review was conducted in all patients who had retrieved hip and/or pelvic radiotherapy for HTO prophylaxis at Sunnybrook Health Sciences Centre between July 1998 and August 2016...
December 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28967339/increased-substance-use-and-poorer-mental-health-in-adolescents-with-problematic-musculoskeletal-pain
#16
Nicola McLaren, Steven J Kamper, Rebecca Hodder, John Wiggers, Luke Wolfenden, Jennifer Bowman, Elizabeth Campbell, Julia Dray, Christopher M Williams
Study Design Cross-sectional study. Background Adolescents with musculoskeletal pain are thought to be at greater risk of modifiable health risk behaviors, but little is known about these behaviors in adolescents with problematic pain. Objective To describe the prevalence of substance use (tobacco smoking, alcohol consumption, and illicit drugs) and poor mental health in adolescents with problematic musculoskeletal pain, compared to those without such pain. Methods Data on self-reported pain, substance use, and poor mental health were collected from 1831 year 9 students (age range, 14-16 years)...
October 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28960382/ultrasonographic-evaluation-of-zone-ii-partial-flexor-tendon-lacerations-of-the-fingers-a-cadaveric-study
#17
Nikolas H Kazmers, Joshua A Gordon, Kristen L Buterbaugh, David J Bozentka, David R Steinberg, Viviane Khoury
OBJECTIVES: Accurate assessment of zone II partial flexor tendon lacerations in the finger is clinically important. Surgical repair is recommended for lacerations of greater than 50% to 60%. Our goal was to evaluate ultrasonographic test characteristics and accuracy in identifying partial flexor tendon lacerations in a cadaveric model. METHODS: From fresh-frozen above-elbow human cadaveric specimens, 32 flexor digitorum profundus tendons were randomly selected to remain intact or receive low- or high-grade lacerations involving 10% to 40% and 60% to 90% of the radioulnar width within Verdan Zone II, respectively...
September 29, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28958273/variation-in-clinical-characteristics-of-women-versus-men-preoperative-for-laparoscopic-roux-en-y-gastric-bypass-analysis-of-83-059-patients
#18
COMPARATIVE STUDY
Jandie Schwartz, Christopher Bashian, Leon Kushnir, Cristina Nituica, Gus J Slotman
Variation by sex in preoperative clinical characteristics of female and male laparoscopic Roux-en-Y gastric bypass (LRYGB) patients has not been evaluated comprehensively. The objective of our study was to identify clinical differences between morbidly obese women and men seeking LRYGB. Data from 83,059 patients in the Surgical Review Corporation's Bariatric Outcomes Longitudinal Database who were about to undergo LRYGB was analyzed in two groups: women (n = 65,325) and men (n = 17,734). Statistics were evaluated with analysis of variance and the χ2 equation...
September 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28919122/functional-movement-screen-pain-versus-composite-score-and-injury-risk
#19
Joseph A Alemany, Timothy T Bushman, Tyson Grier, Morgan K Anderson, Michelle Canham-Chervak, William J North, Bruce H Jones
OBJECTIVES: The Functional Movement Screen (FMS™) has been used as a screening tool to determine musculoskeletal injury risk using composite scores based on movement quality and/or pain. However, no direct comparisons between movement quality and pain have been quantified. DESIGN: Retrospective injury data analysis. METHODS: Male Soldiers (n=2154, 25.0±1.3years; 26.2±.7kg/m(2)) completed the FMS (scored from 0 points (pain) to 3 points (no pain and perfect movement quality)) with injury data over the following six months...
August 23, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28916548/do-comorbidities-play-a-role-in-hand-osteoarthritis-disease-burden-data-from-the-hand-osteoarthritis-in-secondary-care-cohort
#20
Wendy Damman, Rani Liu, Féline P B Kroon, Monique Reijnierse, Tom W J Huizinga, Frits R Rosendaal, Margreet Kloppenburg
OBJECTIVE: Because the association and its clinical relevance between comorbidities and primary hand osteoarthritis (OA) disease burden is unclear, we studied this in patients with hand OA from our Hand OSTeoArthritis in Secondary care (HOSTAS) cohort. METHODS: Cross-sectional data from the HOSTAS study were used, including consecutive patients with primary hand OA. Nineteen comorbidities were assessed: 18 self-reported (modified Charlson index and osteoporosis) and obesity (body mass index ≥ 30 kg/m(2))...
November 2017: Journal of Rheumatology
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