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https://www.readbyqxmd.com/read/29467881/diffuse-large-b-cell-lymphoma-10-years-real-world-clinical-experience-with-rituximab-plus-cyclophosphamide-doxorubicin-vincristine-and-prednisolone
#1
Matej Horvat, Vesna Zadnik, Tanja Južnič Šetina, Lučka Boltežar, Jana Pahole Goličnik, Srdjan Novaković, Barbara Jezeršek Novaković
Treatment with rituximab plus a regimen of cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) for patients with diffuse large B-cell lymphoma (DLBCL) has proven efficacy in clinical trials. The present study investigated its application in clinical practice. This single-center, retrospective database analysis included patients with DLBCL treated at the Slovenian Institute of Oncology Ljubljana between 2004 and 2013. Overall survival (OS) and progression-free survival (PFS) were assessed according to International Prognostic Index (IPI) and revised IPI (R-IPI) categories...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29464806/histopathological-and-immunophenotypic-features-of-ipilimumab-associated-colitis-compared-to-ulcerative-colitis
#2
Brittany L Adler, Maryam K Pezhouh, Amy Kim, Lan Luan, Qingfeng Zhu, Faiz Gani, Mark Yarchoan, Jonathan Chen, Lysandra Voltaggio, Alyssa Parian, Mark Lazarev, Gregory Y Lauwers, Timothy M Pawlik, Elizabeth A Montgomery, Elizabeth Jaffee, Dung T Le, Janis M Taube, Robert A Anders
BACKGROUND: Use of the immune checkpoint inhibitor ipilimumab is sometimes complicated by ipilimumab-associated colitis (Ipi-AC), an immune-mediated colitis that mimics inflammatory bowel disease. OBJECTIVE: We sought to characterize the histopathologic and immunophenotypic features of Ipi-AC, and to directly compare these features to ulcerative colitis (UC). METHODS: This is a retrospective cohort study of 22 patients with Ipi-AC, 12 patients with treatment-naïve UC, and 5 controls with diarrhea but normal endoscopic findings...
February 21, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29460654/cumulative-experience-and-long-term-follow-up-of-pentostatin-based-chemoimmunotherapy-trials-for-patients-with-chronic-lymphocytic-leukemia
#3
Neil E Kay, Betsy R LaPlant, Adam M Pettinger, Timothy G Call, Jose F Leis, Wei Ding, Sameer A Parikh, Michael J Conte, Deborah A Bowen, Tait D Shanafelt
BACKGROUND: 7 regimens of pentostatin based chemoimmunotherapy (CIT) for progressive previously untreated CLL primarily with long term follow-up to update both efficacy and toxicity. RESEARCH DESIGN AND METHODS: Prognostic markers including assessment of IGVH and FISH status were done on all. Response rates and 95% binomial confidence intervals were calculated for each regimen and in the combined cohort. Overall survival and treatment-free survival were evaluated using Kaplan-Meier methods...
February 20, 2018: Expert Review of Hematology
https://www.readbyqxmd.com/read/29457831/low-t3-syndrome-as-a-predictor-of-poor-prognosis-in-chronic-lymphocytic-leukemia
#4
Rui Gao, Rui-Ze Chen, Yi Xia, Jin-Hua Liang, Li Wang, Hua-Yuan Zhu, Jia-Zhu Wu, Lei Fan, Jian-Yong Li, Tao Yang, Wei Xu
Low triiodothyronine (T3) state is associated with poor prognosis in critical acute and prolonged illness. However, the information on thyroid dysfunction and cancer is limited. The aim of our study was to evaluate the prognostic value of low T3 syndrome in chronic lymphocytic leukemia (CLL). Two hundred and fifty-eight patients with detailed thyroid hormone profile at CLL diagnosis were enrolled. Low T3 syndrome was defined by low free T3 (FT3) level accompanied by normal-to-low free tetraiodothyronine (FT4) and thyroid-stimulating hormone (TSH) levels...
February 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29441651/invasive-pneumococcal-infections-in-pediatric-liver-small-bowel-pancreas-transplant-recipients
#5
Hanh D Vo, Diana F Florescu, Cindy R Brown, Heather E Chambers, David F Mercer, Luciano M Vargas, Wendy J Grant, Alan N Langnas, Ruben E Quiros-Tejeira
Children undergoing LSBPTx are at increased risk of IPI due to splenectomy. We aimed to describe the clinical features and outcomes of IPI in pediatric LSBPTx recipients. Between 2008 and 2016, 122 LSBPTx children at our center were retrospectively reviewed. Nine patients had 12 episodes of IPI; the median age at first infection was 3.5 years (range: 1.5-7.1 years). The median time from transplant to first infection was 3 years (range: 0.8-5.8 years). Clinical presentation included as follows: pneumonia (n = 1), bacteremia/sepsis (n = 7), pneumonia with sepsis (n = 1), meningitis with sepsis (n = 2), pneumonia and meningitis with sepsis (n = 1)...
February 13, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29432937/detection-of-vim-2-imp-1-and-ndm-1-producing-multidrug-resistant-pseudomonas-aeruginosa-in-malaysia
#6
Siew Mun Liew, Ganeswrei Rajasekaram, Savithri D Puthucheary, Kek Heng Chua
OBJECTIVES: The increasing incidence of carbapenem-resistant Pseudomonas aeruginosa along with the discovery of novel metallo-β-lactamases (MBLs) is of concern. In this study, the isolation of Malaysian MBL-producing P. aeruginosa clinical strains was investigated. METHODS: Fifty-three P. aeruginosa clinical strains were isolated from different patients in Sultanah Aminah Hospital, Johor Bahru, Malaysia in 2015. Antimicrobial susceptibility test was conducted. Minimum inhibitory concentrations (MICs) of imipenem and meropenem were determined by Etest...
February 9, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29427185/geriatric-nutritional-risk-index-as-a-prognostic-factor-in-patients-with-diffuse-large-b-cell-lymphoma
#7
Yusuke Kanemasa, Tatsu Shimoyama, Yuki Sasaki, Tsunekazu Hishima, Yasushi Omuro
The geriatric nutritional risk index (GNRI) is a simple and well-established nutritional assessment tool that is a significant prognostic factor for various cancers. However, the role of the GNRI in predicting clinical outcomes of diffuse large B cell lymphoma (DLBCL) patients has not been investigated. To address this issue, we retrospectively analyzed a total of 476 patients with newly diagnosed de novo DLBCL. We defined the best cutoff value of the GNRI as 96.8 using a receiver operating characteristic curve...
February 9, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29423584/interpregnancy-interval-and-risk-of-adverse-pregnancy-outcomes-a-register-based-study-of-328-577-pregnancies-in-denmark-1994-2010
#8
Emilie Rune Hegelund, Stine Kjaer Urhoj, Anne-Marie Nybo Andersen, Laust Hvas Mortensen
Objectives To investigate the associations of interpregnancy interval (IPI) with miscarriage, stillbirth, preterm delivery and small for gestational age delivery. Methods The study population comprised all women who had a live birth and at least one subsequent pregnancy in Denmark during the period from 1994 to 2010 (N = 328,577). Linear regression was used to estimate risk differences for miscarriage, stillbirth, preterm delivery and small for gestational age delivery according to IPI. Results The results were heterogeneous: the risk of miscarriage increased monotonically with the length of the IPI...
February 8, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29415639/low-expression-of-mda-7-il-24-and-high-expression-of-c-myb-in-tumour-tissues-are-predictors-of-poor-prognosis-for-burkitt-lymphoma-patients
#9
Ming Ma, Riyang Zhao, Xingxiao Yang, Lianmei Zhao, Lihua Liu, Cong Zhang, Xuexiao Wang, Baoen Shan
OBJECTIVES: Burkitt lymphoma is one of the most common types of haematopoietic malignancy in children and adolescents. Mda-7/IL-24 had been identified as a differentiation inducer of Burkitt lymphoma cells. Previous studies have revealed that knockdown of C-myb can also lead to the terminal differentiation of Burkitt lymphoma cells. The aim of the present study was to investigate the correlation between the expression of Mda-7/IL-24 and C-myb, as well as their prognostic significance, for Burkitt lymphoma patients...
February 8, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29415040/the-role-of-family-size-employment-and-education-of-parents-in-the-prevalence-of-intestinal-parasitic-infections-in-school-children-in-accra
#10
Akua Obeng Forson, Isaac Arthur, Patrick F Ayeh-Kumi
INTRODUCTION: Intestinal parasitic infections (IPIs) in school children are a public health problem in most developing countries. METHODS AND PRINCIPAL FINDINGS: A cross sectional survey was conducted from May to July 2016 with school children living in overcrowded urban slums in Accra, Ghana. A simple random sample of 300 children aged 2-9 years was collected. The study used structured pre-tested questionnaire and stool tests to obtain information on epidemiological, sanitation habits, employment and education status of parents and children...
2018: PloS One
https://www.readbyqxmd.com/read/29401976/simultaneous-location-and-size-measurement-of-particles-using-extended-glare-point-imaging-technique
#11
Lu Qieni, Yu Xiaoxue, Ge Baozhen, Chen Tingting
Interferometric particle imaging (IPI) is a robust and popular technique for measuring particle size and velocity. A method based on a template matching algorithm and an auto-correlation method is proposed to simultaneously extract the location and the separation of doublet images of a particle from an IPI focused image. The position coordinate (x,y) of the particle can be determined with high accuracy, as evaluated by using a serial particle mask. Furthermore, the method can be employed to achieve sub-pixel spacing extraction when combined with Gaussian interpolation...
January 22, 2018: Optics Express
https://www.readbyqxmd.com/read/29397837/-expression-and-clinical-prognostical-significance-of-rip2-in-diffuse-large-b-cell-lymphoma
#12
Xin-Chen Wang, Kai-Yang Ding, Xiao-Qiu Wang, Zhi-Hua Wang, Jue Wang
OBJECTIVE: To investigate the expression and prognosis significance of receptor interacting protein 2 (RIP2) in diffuse large B-cell lymphoma (DLBCL). METHODS: The expression of RIP2 in DLBCL GCB and non-GCB type was detected by immunohistochemistry, at same time the expressions of BCL-2 and C-MYC were detected. Then, the role of RIP2 in development of DLBCL was analyzed by related clinical and pathological parameters. RESULTS: The expression of RIP2 was related with middle-high risk group by IPI score, the An Arbor stage III+IV and intranodal lesions, and the differences were statistically significant (P<0...
February 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29387221/association-between-laptm4b-gene-polymorphism-and-susceptibility-to-and-prognosis-of-diffuse-large-b-cell-lymphoma
#13
Huirong Ding, Xiaojing Cheng, Ning Ding, Zhihua Tian, Jun Zhu, Chunlian Zhou, Jing Shen, Yuqin Song
Lysosomal protein transmembrane 4β (LAPTM4B) is an oncogene that is overexpressed in a number of various types of human cancer. There are two known alleles of LAPTM4B: LAPTM4B*1 and LAPTM4B*2. The present study assessed the association between LAPTM4B polymorphisms and the susceptibility to diffuse large B-cell lymphoma (DLBCL) and its prognosis. LAPTM4B genotypes were determined using polymerase chain reaction analysis in 164 DLBCL and 350 healthy control cases. The association between LAPTM4B polymorphisms and the risk of DLBCL was analyzed using unconditional logistic regression...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29380463/clinicopathologic-implications-of-tnfaip3-a20-deletions-in-extranodal-nk-t-cell-lymphoma
#14
Hyein Ahn, Jeong Mi Yang, Yoon Kyung Jeon, Jin Ho Paik
The A20/Tumor necrosis factor-alpha-induced protein 3 (A20/TNFAIP3) is a negative regulator of NF-κB signaling. We analyzed the clinicopathologic implications of A20 deletions in extranodal NK/T-cell lymphoma (NKTL). Fluorescence in situ hybridization analysis of the A20 gene was performed using archived formalin-fixed tissues in 49 cases of NKTL. Among the 49 NKTL patients (median age, 48 years [10-79]), stage I-II (75% [36/48]) and upper aerodigestive tract (UAT)-origin (84% [41/49]) were predominant. All A20 deletions were monoallelic and found in cases with UAT-origin, accounting for 18% (9/49) of all NKTLs and 22% (9/41) of UAT-origin...
January 30, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29378644/prevalence-of-and-risk-factors-for-malaria-filariasis-and-intestinal-parasites-as-single-infections-or-co-infections-in-different-settlements-of-gabon-central-africa
#15
Noé Patrick M'bondoukwé, Eric Kendjo, Denise Patricia Mawili-Mboumba, Jeanne Vanessa Koumba Lengongo, Christelle Offouga Mbouoronde, Dieudonné Nkoghe, Fousseyni Touré, Marielle Karine Bouyou-Akotet
BACKGROUND: Malaria, filariasis, and intestinal parasitic infections (IPIs) are common and frequently overlap in developing countries. The prevalence and predictors of these infections were investigated in three different settlements (rural, semi-urban, and urban) of Gabon. METHODS: During cross-sectional surveys performed from September 2013 to June 2014, 451 individuals were interviewed. In addition, blood and stool samples were analysed for the presence of Plasmodium, filarial roundworm, intestinal protozoan, and helminth infections...
January 30, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29362889/computer-driven-quantitative-image-analysis-in-the-assessment-of-tumor-cell-and-t-cell-features-in-diffuse-large-b-cell-lymphomas
#16
Francesco Gaudio, Roberto Tamma, Giuseppe Ingravallo, Tommasina Perrone, Filomena Emanuela Laddaga, Mariastella De Candia, Eugenio Maiorano, Domenico Ribatti, Giorgina Specchia
Diffuse large B cell lymphoma (DLBCL) is recognized as the most common non-Hodgkin lymphoma subtype. Advanced high-resolution digital scans of pathology slides have enabled the development of computer-based image analysis algorithms that may assist pathologists in quantifying immunohistochemical stains. In this retrospective study, we reviewed data from 29 patients affected by DLBCL. In order to evaluate the number of tumor cells and microenvironment T cells, we performed an analysis of CD20, Ki67, and CD3 counts, assessed with the Positive Pixel Count algorithm embedded in the Aperio ImageScope software...
January 23, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29352718/consolidative-radiotherapy-to-residual-masses-after-chemotherapy-is-associated-with-improved-outcome-in-diffuse-large-b-cell-lymphoma-a-retrospective-population-based-study
#17
Øystein Fluge, Bård Mannsåker, Anders Torp, Ingvil Mjaaland, Lars Helgeland, Jan Klos, Olav Mella, Sigbjørn Berentsen, Peter Meyer
BACKGROUND: The role of consolidative radiotherapy (RT) in advanced diffuse large B-cell lymphoma (DLBCL) is not established. PATIENTS AND METHODS: In a population-based retrospective analysis of patients with DLBCL in Western Norway during 2003 to 2008, 170 consecutive patients admitted to Haukeland University Hospital (HUS) and 94 to Stavanger University Hospital (SUS) were included. The mean age was 64 years (range, 17-95 years), 147 patients (56%) were male, 80 patients (30%) had stage I/II, 126 patients (48%) stage III/IV, and 57 patients (22%) had primary extranodal disease...
December 24, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29348421/patients-over-40-years-old-with-precursor-t-cell-lymphoblastic-lymphoma-have-different-prognostic-factors-comparing-to-the-youngers
#18
Meng Dong, Xudong Zhang, Zhenzhen Yang, Shaoxuan Wu, Mijing Ma, Zhaoming Li, Yu Chang, Xinhua Wang, Ling Li, Xin Li, Mingzhi Zhang, Qingjiang Chen
This study aimed to analyze the clinical characteristics and prognostic factors of patients, divided into over 40-year-old group or not, with precursor T-cell lymphoblastic lymphoma (Pre-T-LBL). Based on the retrospective analysis of the clinical data of 59 patients with Pre-T-LBL during the period from December 2010 to December 2015, albumin level, anemia, pleural or pericardial effusion, protocol, therapy response, mediastinal mass, lactate dehydrogenase (LDH), and international prognostic index (IPI) or age-adjusted international prognostic index (aaIPI) were summarized...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29344120/interim-18f-fdg-pet-ct-improves-the-prognostic-value-of-s-ipi-r-ipi-and-nccn-ipi-in-patients-with-diffuse-large-b-cell-lymphoma
#19
Maoqing Jiang, Ping Chen, Xinzhong Ruan, Xianwang Ye, Yuning Pan, Jie Zhang, Qiuli Huang, Wenlan Zhou, Hubing Wu, Quanshi Wang
The current study aimed to explore whether the efficiency of the standard International Prognostic Index (S-IPI), revised-IPI (R-IPI) and enhanced-IPI (NCCN-IPI) in evaluating the prognosis of patients with diffuse large B-cell lymphoma (DLBCL) may be improved by interim 18F-FDG PET/CT. A total of 185 patients with newly diagnosed DLBCL were enrolled in the current study. All patients underwent interim PET/CT following the 4th cycle of chemotherapy. Patients were divided into different risk groups using S-IPI, R-IPI and NCCN-IPI and further subdivided into risk groups using interim PET/CT...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29333404/relevance-of-prognostic-index-with-%C3%AE-2-microglobulin-for-patients-with-diffuse-large-b-cell-lymphoma-in-the-rituximab-era
#20
Jihoon Kang, Shinkyo Yoon, Cheolwon Suh
Background: The International Prognostic Index (IPI) has been a useful tool for predicting the prognosis of aggressive non-Hodgkin lymphoma in the last 20 years. Herein, we aimed to develop a new prognostic model for diffuse large B-cell lymphoma (DLBCL) in the rituximab era. Methods: Between March 2004 and June 2012, patients with DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy regimen were identified in the database of the Asan Medical Center (AMC) Lymphoma Registry...
December 2017: Blood Research
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