keyword
MENU ▼
Read by QxMD icon Read
search

Ipi

keyword
https://www.readbyqxmd.com/read/29242726/relationship-between-dual-time-point-fdg-pet-ct-and-clinical-prognostic-indexes-in-patients-with-high-grade-lymphoma-a-pilot-study
#1
Do Hyoung Lim, Jai Hyuen Lee
Purpose: This study investigated the correlative relationship between metabolic parameters estimated from dual time point 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG) positron emission tomography/computerized tomography (PET/CT) and the clinical tools predicting the outcome of a lymphoma. We also measured metabolic and volumetric alterations between early and delayed 18F-FDG PET/CT in patients with high grade lymphoma (HGL). Methods: The samples were 122 lymph nodes and extralymphatic lesions from 26 patients diagnosed with HGL...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29239133/simplicity-at-the-cost-of-predictive-accuracy-in-diffuse-large-b-cell-lymphoma-a-critical-assessment-of-the-r-ipi-ipi-and-nccn-ipi
#2
Jorne Biccler, Sandra Eloranta, Peter de Nully Brown, Henrik Frederiksen, Mats Jerkeman, Karin E Smedby, Martin Bøgsted, Tarec C El-Galaly
The international prognostic index (IPI) and similar models form the cornerstone of clinical assessment in newly diagnosed diffuse large B-cell lymphoma (DLBCL). While being simple and convenient to use, their inadequate use of the available clinical data is a major weakness. In this study, we compared performance of the International Prognostic Index (IPI) and its variations (R-IPI and NCCN-IPI) to a Cox proportional hazards (CPH) model using the same covariates in nondichotomized form. All models were tested in 4863 newly diagnosed DLBCL patients from population-based Nordic registers...
December 13, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29234945/clinical-significance-and-functional-validation-of-inorganic-pyrophosphatase-in-diffuse-large-b-cell-lymphoma-in-humans
#3
Limei Li, Aruna, Dehong Luo, Arong Jin
Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin's lymphoma, displays marked heterogeneity. Although it is usually curable, 30-40% of patients die within 1-2 years due to refractory treatment or cancer relapse. In different types of cancer in humans, inorganic pyrophosphatase (PPA1) is deregulated, thereby contributing to tumorigenesis by supplying the tumor with an enormous energy source. However, the role of PPA1 in DLBCL is still unclear. Here, we analized PPA1 in 65 patients with DLBCL and 20 patients with reactive hyperplasia of the lymph nodes (control)...
December 12, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29233821/activity-of-the-pi3k-%C3%AE-%C3%AE-inhibitor-duvelisib-in-a-phase-i-trial-and-preclinical-models-of-t-cell-lymphoma
#4
Steven M Horwitz, Raphael Koch, Pierluigi Porcu, Yasuhiro Oki, Alison Moskowitz, Megan Perez, Patricia Myskowski, Adam Officer, Jacob D Jaffe, Sara N Morrow, Kerstin Allen, Mark Douglas, Howard Stern, Jennifer Sweeney, Patrick Kelly, Virginia Kelly, Jon C Aster, David Weaver, Francine M Foss, David M Weinstock
Duvelisib (IPI-145) is an oral inhibitor of phosphoinositide-3-kinase (PI3K)-δ/γ isoforms currently in clinical development. PI3K-δ/γ inhibition may directly inhibit malignant T-cell growth, making Duvelisib a promising candidate for patients with peripheral (PTCL) or cutaneous (CTCL) T-cell lymphoma. Inhibition of either isoform may also contribute to clinical responses by modulating nonmalignant immune cells. We investigated these dual effects in a TCL cohort from a Phase 1, open-label study of Duvelisib in patients with relapsed or refractory PTCL [n=16] and CTCL [n=19], along with in vitro and in vivo models of TCL...
December 12, 2017: Blood
https://www.readbyqxmd.com/read/29226652/a-pooled-analysis-of-the-clinical-utilities-of-long-non-coding-rna-based-molecular-signature-for-diffuse-large-b-cell-lymphoma
#5
Pei Xu, Xiaoli Chen, Panke Su
BACKGROUND: Long non-coding RNAs (lncRNAs) have been highlighted as promising biomarkers for several types of malignancies. The current meta-analysis sought to investigate the clinical value of lncRNA-based molecular signatures as biomarkers for diagnosis, subtype classification, and prognosis in diffuse large B cell lymphoma (DLBCL). METHODS: A systematic search of the online databases was carried out and data were retrieved by pairs of independent reviewers. Effect sizes of the diagnostic parameters were combined using a quantitative meta-analysis...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29214417/diagnostic-and-prognostic-value-of-baseline-fdg-pet-ct-skeletal-textural-features-in-diffuse-large-b-cell-lymphoma
#6
Nicolas Aide, Marjolaine Talbot, Christophe Fruchart, Gandhi Damaj, Charline Lasnon
PURPOSE: Our purpose was to evaluate the diagnostic and prognostic value of skeletal textural features (TFs) on baseline FDG PET in diffuse large B cell lymphoma (DLBCL) patients. METHODS: Eighty-two patients with DLBCL who underwent a bone marrow biopsy (BMB) and a PET scan between December 2008 and December 2015 were included. Two readers blinded to the BMB results visually assessed PET images for bone marrow involvement (BMI) in consensus, and a third observer drew a volume of interest (VOI) encompassing the axial skeleton and the pelvis, which was used to assess skeletal TFs...
December 7, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29209623/myc-gene-rearrangements-are-closely-associated-with-poor-survival-of-diffuse-large-b-cell-lymphoma-with-hepatitis-b-virus-infection
#7
Zhihe Liu, Siyun Li, Wei Guo, Yinping Wang, Ming Wang, Ou Bai
The aim of this study was to identify clinical adverse prognostic factors affecting overall survival (OS) of diffuse large B cell (DLBCL) patients with hepatitis B virus (HBV) infection. In this study, 30 DLBCL patients with HBV infection and 51 DLBCL patients with HBV-free were reviewed retrospectively. As of July 2016, the median follow-up period was 26.4 months (3.0~65.0 months). The median OS of patients in HBV infection group was 38.6 months, while that of patients in HBV-free group was not reached (P = 0...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29199519/outcomes-of-da-epoch-r-induction-plus-autologous-transplant-consolidation-for-double-hit-lymphoma
#8
Andy I Chen, Jessica T Leonard, Craig Y Okada, Nathan D Gay, Kari Chansky, Guang Fan, Jennifer B Dunlap, Philipp W Raess, Rita M Braziel, Alex Stentz, Richard T Maziarz
High-grade B cell lymphoma with MYC and BCL2 rearrangements (double hit) has a poor prognosis with standard R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone). We report here a treatment algorithm of DA-EPOCH-R (dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, rituximab) followed by BEAM (carmustine, etoposide, cytarabine, melphalan) autologous transplant in 36 cases of previously untreated double hit lymphoma (DHL) from 2010 to 2015. A high risk International Prognostic Index (IPI) was present in 42% of cases...
December 3, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29198127/immunohistochemical-investigation-of-p16-p53-and-ki-67-s-prognostic-values-in-diffuse-large-b-cell-lymphomas
#9
M Baran, O Canoz, H Altuntas, S Sivgin, M Cetin, A Yay, S Ketenci
AIM: The aim of this study is to determine the immunohistochemical properties of Ki-67, P53 expression and loss of P16, and to assess their relationship with both clinical parameters and patient survival in DLBCL. METHOD: Forty patients, diagnosed at the Pathology Department of our institute with nodal DLBCL were selected as the study group. The relationship between P16, P53, Ki-67 expressions and clinical and laboratory parameters like age, gender, performance status, Eastern Cooperative Oncology Group (ECOG), clinical stage, presence of B-symptoms, bone marrow involvement, International Prognostic Index (IPI) score, lactate dehydrogenase (LDH) level, extranodal extension, relapse, C-reactive protein (CRP), sedimentation, number of leukocytes in patients and patient survival were then statistically evaluated...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29194714/survival-following-salvage-therapy-for-primary-refractory-peripheral-t-cell-lymphomas-ptcl
#10
Janie Y Zhang, Robert Briski, Sumana Devata, Mark S Kaminski, Tycel J Phillips, Tera L Mayer, Nathanael G Bailey, Ryan A Wilcox
Optimal salvage therapy for primary refractory peripheral T-cell lymphomas (PTCL) and the role of hematopoietic stem cell transplant remain poorly defined. We conducted a retrospective review of clinical outcomes and prognostic factors in a single-center cohort of 93 patients with primary refractory PTCL, defined as progression during first-line therapy or relapse within 6 months of its completion. Clinical outcomes were poor in this population, with median event-free survival (EFS) of 3.5 months, median overall survival (OS) of 9...
December 1, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29191916/duvelisib-a-novel-oral-dual-inhibitor-of-pi3k-%C3%AE-%C3%AE-is-clinically-active-in-advanced-hematologic-malignancies
#11
Ian W Flinn, Susan O'Brien, Brad Kahl, Manish Patel, Yasuhiro Oki, Francine F Foss, Pierluigi Porcu, Jeffrey Jones, Jan A Burger, Nitin Jain, Virginia M Kelly, Kerstin Allen, Mark Douglas, Jennifer Sweeney, Patrick Kelly, Steven Horwitz
Duvelisib (IPI-145) is a novel, oral, dual inhibitor of phosphoinositide 3-kinase (PI3K)-δ and PI3K-γ in late-stage clinical development for treatment of hematologic malignancies. This Phase 1 study (registered as NCT01476657 at ClinicalTrials.gov) evaluated the maximum tolerated dose (MTD), pharmacokinetics (PK), pharmacodynamics (PD), efficacy, and safety of duvelisib in 210 patients with advanced hematologic malignancies. In the Dose Escalation Phase (n=31), duvelisib 8 to 100 mg BID was administered, with MTD determined to be 75 mg BID...
November 30, 2017: Blood
https://www.readbyqxmd.com/read/29191114/gene-cg15630-fipi-is-involved-in-regulation-of-the-interpulse-interval-in-drosophila-courtship-song
#12
Sergey A Fedotov, Julia V Bragina, Natalia G Besedina, Larisa V Danilenkova, Elena A Kamysheva, Nikolai G Kamyshev
To study the central pattern generators functioning, previously we identified genes, whose neurospecific knockdowns led to deviations in the courtship song of Drosophila melanogaster males. Reduced expression of the gene CG15630 caused a decrease in the interpulse interval. To investigate the role of CG15630, which we have called here fipi (factor of interpulse interval), in the courtship song production, at first, we have characterized fipi transcripts and protein (FIPI) in the mutant flies carrying P insertion and deletions in this gene and in flies with its RNAi knockdown...
November 30, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/29190934/red-blood-cell-distribution-width-as-a-predictor-of-survival-in-nasal-type-extranodal-natural-killer-t-cell-lymphoma
#13
Huaichao Luo, Xiaoying Quan, Xiao-Yu Song, Li Zhang, Yilin Yin, Qiao He, Shaolei Cai, Shi Li, Jian Zeng, Qing Zhang, Yu Gao, Sisi Yu
We retrospectively enrolled 191 nasal-type, extranodal natural killer/T-cell lymphoma (ENKTL) patients newly diagnosed from 2008 to 2016 at the Sichuan Cancer Hospital, in order to evaluate the relationship between disease outcomes, demographic and clinical factors, and red blood cell distribution width (RDW). C-index, fisher's exact test, univariate analysis, and cox regression analysis were applied. The median age of patients was 44 years and 134 (70%) were men. The cutoff of RDW was 46.2 fL determined by Cutoff Finder...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29190915/the-prognostic-significance-of-cd11b-cx3cr1-monocytes-in-patients-with-newly-diagnosed-diffuse-large-b-cell-lymphoma
#14
Ho-Young Yhim, Jeong-A Kim, Sun-Hye Ko, Youngrok Park, Eunjung Yim, Hee Sun Kim, Jae-Yong Kwak
Despite their critical roles in angiogenesis and host immunosuppression within the tumor microenvironment, the prognostic significance of myeloid-lineage cells expressing CD11b and CX3CR1 in diffuse large B-cell lymphoma (DLBCL) has not been well studied. We prospectively enrolled newly-diagnosed DLBCL patients at two Korean institutions between May 2011 and Aug 2015. CD11b+CX3CR1+ cells were analyzed by flow cytometry using peripheral blood (PB) and bone marrow (BM) aspirate samples before treatments. Eighty-nine patients (52 males) were enrolled...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29190906/improved-prognostic-stratification-using-nccn-and-geltamo-international-prognostic-index-in-patients-with-diffuse-large-b-cell-lymphoma
#15
Junshik Hong, Seok Jin Kim, Myung Hee Chang, Jeong-A Kim, Jae-Yong Kwak, Jin Seok Kim, Dok Hyun Yoon, Won Sik Lee, Young Rok Do, Hye Jin Kang, Hyeon-Seok Eom, Yong Park, Jong-Ho Won, Yeung-Chul Mun, Hyo Jung Kim, Jung Hye Kwon, Jee Hyun Kong, Sung Yong Oh, Sunah Lee, Sung Hwa Bae, Deok-Hwan Yang, Hyun Jung Jun, Ho Sup Lee, Hwan Jung Yun, Soon Il Lee, Min Kyoung Kim, Jun Ho Yi, Jae Hoon Lee, Won Seog Kim, Cheolwon Suh
The National Comprehensive Cancer Network (NCCN)-International Prognostic Index (IPI) and GELTAMO (Grupo Español de Linfomas/Trasplante Autólogo de Médula Ósea)-IPI were developed to enable better risk prediction of patients with diffuse large B-cell lymphoma (DLBCL). The present study compared the effectiveness of risk prediction between IPI, NCCN-IPI, and GELTAMO-IPI in patients with DLBCL particularly in terms of determining high-risk patients. Among 439 patients who were enrolled to a prospective DLBCL cohort treated with R-CHOP immunochemotherapy, risk groups were classified according to the three IPIs and the prognostic significance of individual IPI factors and IPI models were analyzed and compared...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29186069/risk-assessment-and-source-identification-of-17-metals-and-metalloids-on-soils-from-the-half-century-old-tungsten-mining-areas-in-lianhuashan-southern-china
#16
Li Guo, Weituo Zhao, Xiaowen Gu, Xinyun Zhao, Juan Chen, Shenggao Cheng
Background: Mining activities always emit metal(loid)s into the surrounding environment, where their accumulation in the soil may pose risks and hazards to humans and ecosystems. Objective: This paper aims to determine of the type, source, chemical form, fate and transport, and accurate risk assessment of 17 metal(loid) contaminants including As, Cd, Cu, Ni, Pb, Zn, Cr, Ag, B, Bi, Co, Mo, Sb, Ti, V, W and Sn in the soils collected from an abandoned tungsten mining area, and to guide the implementing of appropriate remediation strategies...
November 29, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29164825/autism-spectrum-disorder-and-birth-spacing-findings-from-the-study-to-explore-early-development-seed
#17
Laura A Schieve, Lin H Tian, Carolyn Drews-Botsch, Gayle C Windham, Craig Newschaffer, Julie L Daniels, Li-Ching Lee, Lisa A Croen, M Danielle Fallin
Previous studies of autism spectrum disorder (ASD) and birth spacing had limitations; few examined phenotypic case subtypes or explored underlying mechanisms for associations and none assessed whether other (non-ASD) developmental disabilities (DDs) were associated with birth spacing. We assessed associations between inter-pregnancy interval (IPI) and both ASD and other DDs using data from the Study to Explore Early Development, a multi-site case-control study with rigorous case-finding and case-classification methods and detailed data collection on maternal reproductive history...
November 22, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29137104/tumor-and-bone-marrow-uptakes-on-18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-predict-prognosis-in-patients-with-diffuse-large-b-cell-lymphoma-receiving-rituximab-containing-chemotherapy
#18
Chin-Chuan Chang, Shih-Feng Cho, Hung-Pin Tu, Chia-Yang Lin, Ya-Wen Chuang, Shu-Min Chang, Wen-Ling Hsu, Ying-Fong Huang
The purpose of this study was to determine the relevance of standardized uptake value (SUV) on [F]fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), focusing on tumor and bone marrow, to disease outcomes based on progression-free survival (PFS) and overall survival (OS) in patients with diffuse large B-cell lymphoma (DLBCL) receiving rituximab-containing chemotherapy.We reviewed the records of patients with DLBCL who were diagnosed between September 2009 and January 2013 and underwent pretreatment whole-body FDG PET/CT scans...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29130134/is-it-possible-to-improve-prognostic-value-of-nccn-ipi-in-patients-with-diffuse-large-b-cell-lymphoma-the-prognostic-significance-of-comorbidities
#19
Darko Antic, Jelena Jelicic, Goran Trajkovic, Milena Todorovic Balint, Jelena Bila, Olivera Markovic, Ivan Petkovic, Vesna Nikolic, Bosko Andjelic, Vladislava Djurasinovic, Aleksandra Sretenovic, Mihailo Smiljanic, Vojin Vukovic, Biljana Mihaljevic
The prognostic value of the International Prognostic Index (IPI) has been re-evaluated in the rituximab-treated diffuse large B cell lymphoma (DLBCL) patients. Accordingly, National Comprehensive Cancer Network-IPI (NCCN-IPI) has been introduced to estimate prognosis of DLBCL patients. However, comorbidities that frequently affect elderly DLBCL patients were not analyzed. The aim of this study was to evaluate the prognostic significance of comorbidities using Charlson Comorbidity Index (CCI) in 962 DLBCL patients...
November 12, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29123411/increased-histone-deacetylase-6-expression-serves-as-a-favorable-prognostic-factor-for-diffuse-large-b-cell-lymphoma
#20
Xiao-Ji Lin, Li-Meng Cai, Zi-Jun Qian, Chen-Yi Wang, Ni Sun, Xiao-Hai Sun, He Huang, Wen-Jian Guo, Hai-Yan Lin, Rong-Xin Yao
Objective: This study aims to investigate ectopic expression of histone deacetylase 6 (HDAC6) in diffuse large B-cell lymphoma (DLBCL). Methods: This study analyzed patients with DLBCL (n=132) and reactive lymph node hyperplasia (n=32) diagnosed in our hospital from December 2007 to May 2016. Correlation between HDAC6 expression and clinical pathologic features was analyzed by χ(2) test. The significant differences between the 5-year overall survival (OS) or progression-free survival (PFS) and high HDAC6 expression as well as DLBCL clinic-pathological features including age, International Prognostic Index (IPI) score, Eastern Cooperative Oncology Group score, lactate dehydrogenase (LDH), and germinal center B-cell-like were assessed by univariate and multivariate analyses...
2017: OncoTargets and Therapy
keyword
keyword
8788
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"