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https://www.readbyqxmd.com/read/29144965/role-of-serum-1-3%C3%AE-d-glucan-assay-in-early-diagnosis-of-invasive-fungal-infections-in-a-neonatal-intensive-care-unit
#1
Abd Elazeez Shabaan, Lobna Mahmoud Elbaz, Wafaa M El-Emshaty, Basma Shouman
OBJECTIVES: To study the microbiological pattern of late onset neonatal sepsis cultures and to assess the diagnostic performance of serum (1,3)-β-d-glucan level for early diagnosis of invasive fungemia in high-risk infants admitted to a neonatal intensive care unit. METHODS: A prospective multicenter clinical trial conducted on infants at high risk for invasive fungal infections, with suspected late onset sepsis, admitted to a neonatal intensive care unit at Mansoura University Children's Hospital and Mansoura General Hospital between March 2014 and February 2016...
November 13, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/29143632/a-method-for-estimating-maternal-and-newborn-lives-saved-from-health-related-investments-funded-by-the-uk-government-department-for-international-development-using-the-lives-saved-tool
#2
Ingrid K Friberg, Angela Baschieri, Jo Abbotts
BACKGROUND: In 2010, the UK Government Department for International Development (DFID) committed through its 'Framework for results for reproductive, maternal and newborn health (RMNH)' to save 50,000 maternal lives and 250,000 newborn lives by 2015. They also committed to monitoring the performance of this portfolio of investments to demonstrate transparency and accountability. Methods currently available to directly measure lives saved are cost-, time-, and labour-intensive. The gold standard for calculating the total number of lives saved would require measuring mortality with large scale population based surveys or annual vital events surveillance...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29135369/t-cell-immunity-to-zika-and-dengue-viral-infections
#3
Jinsheng Wen, Sujan Shresta
The 2015-2016 Zika virus (ZIKV) outbreak in the Americas has brought this relatively unknown flavivirus into the spotlight as the etiologic agent of congenital Zika syndrome in newborns and, potentially, of Guillain-Barré syndrome in adults. ZIKV shares a high degree of amino acid sequence homology with the closely related flavivirus Dengue virus (DENV). Due to the paucity of research investigating T cell-mediated immune responses to ZIKV, the precise roles of T cells in protection against and pathogenesis of ZIKV infection are unclear...
November 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29133154/adverse-birth-outcomes-associated-with-zika-virus-exposure-during-pregnancy-in-s%C3%A3-o-jos%C3%A3-do-rio-preto-brazil
#4
Mauricio Lacerda Nogueira, Nivison Ruy Rocha Nery Júnior, Cássia Fernanda Estofolete, Ana Carolina Bernardes Terzian, Georgia de Freitas Guimarães, Nathalia Zini, Rafael Alves da Silva, Gislaine Celestino Dutra Silva, Ligia Cosentino Junqueira Franco, Paula Rahal, Cintia Bittar, Bruno Carneiro, Pedro Fernando Vasconcelos da Costa, Daniele Freitas Henriques, Deusenia Machado Ulisses Barbosa, Patrícia Lopes Rombola, Luciana de Grande, Andréia Francesli Negri Reis, Sacha Ariane Palomares, Marcia Wakai Catelan, Lilian Elisa Arão Antonio Cruz, Silvia Helena Necchi, Rita de Cassia Vilella Mendonça, Izalco Nuremberg Penha Dos Santos, Suzimeiri Brigatti Alavarse Caron, Federico Costa, Fernando A Bozza, Antonio Soares de Souza, Cinara Cássia Brandão de Mattos, Luiz Carlos de Mattos, Nikos Vasilakis, Antonio Helio Oliani, Denise Cristina Mós Vaz Oliani, Albert Icksang Ko
OBJECTIVE: We aimed to report the first 54 cases of pregnant women infected by Zika vírus (ZIKV) and their virological and clinical outcomes, as well as the newborns' outcomes in 2016, after the emergence of ZIKV in dengue endemic areas of São Paulo, Brazil. METHODS: This is a descriptive study performed from February to October 2016 on 54 qPCR ZIKV-positive pregnant women identified by the Public Health Authority of São Jose do Rio Preto, São Paulo, Brazil...
November 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29133066/-qtc-interval-in-the-neonatal-period-in-a-mexican-population-a-pilot-study
#5
Rocio Alejandra Peña-Juárez, Adrián Garcia-Canales, Luis Martin Garrido-García, Cesar Augusto Valerio-Carballo
INTRODUCTION: QT interval prolongation is associated with ventricular arrhythmias and sudden death syndrome. OBJECTIVE: To determine the value of QTc interval in healthy newborns in a general hospital in Jalisco, Mexico, and their outcome during their first months of life. METHODS: The study included healthy newborns from March to November 2016, in the Hospital General of Occidente in Jalisco, Mexico. A 12-lead electrocardiogram was performed at a speed of 25mm/s during the first 48h of life...
November 10, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/29132459/-short-term-clinical-outcomes-of-neonates-of-secundiparous-mothers-a-single-center-cohort-study
#6
Ai-Juan Yang, Ke-Ping Cheng, Xiao-Lu Ma, Li-Zhong DU
OBJECTIVE: To investigate the short-term clinical outcomes of neonates of secundiparous mothers, and to provide a reference for the clinical practice after the change in birth policy. METHODS: A cohort study was performed for the parturients and their neonates born in Yongkang Maternal and Child Health Care Hospital in Zhejiang, China between June 2015 and April 2016. According to the parity of the mother, the neonates were divided into primiparous group and secundiparous group...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29128850/exploring-the-newborn-head-diameters-in-relation-to-current-obstetric-forceps-dimensions-a-systematic-review
#7
Abdul-Qader T Ismail, Derick Yates, Jonathan Chester, Khaled M K Ismail
OBJECTIVE: The aim of this study was to systematically search the literature for studies that reported term neonate head size and shape, in an attempt to determine the most appropriate dimensions for the obstetric forceps. STUDY DESIGN: We searched the Ovid Medline, Ovid Embase and Ebscohost CINAHL databases from inception to February 2016. We predefined inclusion criteria to identify studies in which head width and length of asymptomatic, term neonates were measured soon after birth using direct, non-photographic methods A bespoke quality assessment score was used to evaluate the identified studies...
October 28, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29120458/precision-newborn-screening-for-lysosomal-disorders
#8
Melissa M Minter Baerg, Stephanie D Stoway, Jeremy Hart, Lea Mott, Dawn S Peck, Stephanie L Nett, Jason S Eckerman, Jean M Lacey, Coleman T Turgeon, Dimitar Gavrilov, Devin Oglesbee, Kimiyo Raymond, Silvia Tortorelli, Dietrich Matern, Lars Mørkrid, Piero Rinaldo
PurposeThe implementation of newborn screening for lysosomal disorders has uncovered overall poor specificity, psychosocial harm experienced by caregivers, and costly follow-up testing of false-positive cases. We report an informatics solution proven to minimize these issues.MethodsThe Kentucky Department for Public Health outsourced testing for mucopolysaccharidosis type I (MPS I) and Pompe disease, conditions recently added to the recommended uniform screening panel, plus Krabbe disease, which was added by legislative mandate...
November 9, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29114367/the-comparison-of-anti-seizure-and-tocolytic-effects-of-phenytoin-and-magnesium-sulphate-in-the-treatment-of-eclampsia-and-preeclampsia-a-randomised-clinical-trial
#9
Maryam Khooshideh, Majid Ghaffarpour, Sama Bitarafan
Background: To date, magnesium sulphate (MgSO4) is the treatment of choice for prevention of seizure in eclampsia and preeclampsia. However, there are some limitations in the administration of MgSO4 due to its tocolytic effects. The aim of this study was to compare the anticonvulsant and tocolytic effects of MgSO4 and another drug, phenytoin, in patients with eclampsia and preeclampsia. Methods: This clinical trial was conducted on pregnant women hospitalised with eclampsia or preeclampsia, during 2014-2016...
July 6, 2017: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/29104181/evaluation-of-newborn-sickle-cell-screening-programme-in-england-2010-2016
#10
Allison Streetly, Rupa Sisodia, Moira Dick, Radoslav Latinovic, Kirsty Hounsell, Elizabeth Dormandy
OBJECTIVE: To evaluate England's NHS newborn sickle cell screening programme performance in children up to the age of 5 years. DESIGN: Cohort of resident infants with sickle cell disease (SCD) born between 1 September 2010 and 31 August 2015 and followed until August 2016. PARTICIPANTS: 1317 infants with SCD were notified to the study from all centres in England and 1313 (99%) were followed up. INTERVENTIONS: Early enrolment in clinical follow-up, parental education and routine penicillin prophylaxis...
November 5, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29094456/a-prospective-cause-of-death-classification-system-for-maternal-deaths-in-low-and-middle-income-countries-results-from-the-global-network-maternal-newborn-health-registry
#11
Omrana Pasha, Elizabeth M McClure, Sarah Saleem, Shiyam Sunder, Adrien Lokangaka, Antoinette Tshefu, Carl L Bose, Melissa Bauserman, Musaku Mwenechanya, Elwyn Chomba, Waldemar A Carlo, Ana L Garces, Lester Figueroa, K Michael Hambidge, Nancy F Krebs, Shivaprasad Goudar, Bhalachandra S Kodkany, Sangappa Dhaded, Richard J Derman, Archana Patel, Patricia L Hibberd, Fabian Esamai, Constance Tenge, Edward A Liechty, Janet L Moore, Dennis D Wallace, Marion Koso-Thomas, Menachem Miodovnik, Robert L Goldenberg
OBJECTIVE: To describe the causes of maternal death in a population-based cohort in six low and middle-income countries using a standardized, hierarchical, algorithmic cause of death (COD) methodology. DESIGN: A population-based, prospective observational study. SETTING: Seven sites in six low-middle income countries including the Democratic Republic of the Congo (DRC), Guatemala, India (2), Kenya, Pakistan and Zambia. POPULATION: All deaths amongst pregnant women resident in the study sites from 2014 to December 2016...
November 1, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29094370/post-ebola-situational-assessment-of-opportunities-for-capacity-building-at-the-national-obstetrics-and-gynecology-referral-hospital-in-sierra-leone
#12
Rachel Chan Seay, Alimamy P Koroma, Jenell Coleman, John Sampson, Lucy Koroma, Emmanuel A Ugwa, Jean Anderson
OBJECTIVE: To describe a site assessment of the Princess Christian Maternity Hospital (PCMH; Freetown, Sierra Leone), the national referral center for reproductive, maternal, newborn, child and adolescent health (RMNCAH) services and logical site for focused efforts to train and expand the RMNCAH workforce in Sierra Leone. METHODS: In April 2016, a mixed-methods assessment approach was used involving facility observation and staff interviews using the WHO's Service Availability and Readiness Assessment (SARA) tool...
November 2, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29080986/use-of-the-t%C3%A3-bingen-splint-for-the-initial-management-of-severely-dysplastic-and-unstable-hips-in-newborns-with-ddh-an-alternative-to-fettweis-plaster-and-pavlik-harness
#13
Hannes Kubo, Hakan Pilge, Kristina Weimann-Stahlschmidt, Karoline Stefanovska, Bettina Westhoff, Ruediger Krauspe
AIM: Hip dysplasia is one of the most common skeletal disorders. As a late consequence 20-25% of the patients are at risk to develop secondary osteoarthritis and may require total hip replacement early in life. The treatment principles of hip dislocation are (1) concentric reposition, (2) retention, i.e., plaster in human post or Pavlik harness and (3) maturation in abduction flexion orthesis. The Tübingen splint was introduced as a further development of abduction devices for the treatment of (residual) hip dysplasia with stable hips...
October 28, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29079012/a-historical-and-current-review-of-newborn-screening-for-neuromuscular-disorders-from-around-the-world-lessons-for-the-united-states
#14
REVIEW
Lainie Friedman Ross, Angus John Clarke
BACKGROUND: We aimed to review the history of newborn screening for three neuromuscular disorders (Duchenne muscular dystrophy, Pompe disease, and spinal muscular atrophy [SMA]) to determine best practices. METHODS: The history of newborn screening for Duchenne muscular dystrophy began in 1975 with the measurement of creatinine kinase on newborn male blood spots from two Midwestern hospitals in the United States. Over the next 40 years, ten programs were implemented around the globe although none currently remain...
August 25, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29077984/neurally-adjusted-ventilatory-assist-compared-to-other-forms-of-triggered-ventilation-for-neonatal-respiratory-support
#15
REVIEW
Thomas E Rossor, Katie A Hunt, Sandeep Shetty, Anne Greenough
BACKGROUND: Effective synchronisation of infant respiratory effort with mechanical ventilation may allow adequate gas exchange to occur at lower peak airway pressures, potentially reducing barotrauma and volutrauma and development of air leaks and bronchopulmonary dysplasia. During neurally adjusted ventilatory assist ventilation (NAVA), respiratory support is initiated upon detection of an electrical signal from the diaphragm muscle, and pressure is provided in proportion to and synchronous with electrical activity of the diaphragm (EADi)...
October 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29073229/effect-of-a-package-of-integrated-demand-and-supply-side-interventions-on-facility-delivery-rates-in-rural-bangladesh-implications-for-large-scale-programs
#16
Sayedur Rahman, Aziz Ahmed Choudhury, Rasheda Khanam, Syed Mamun Ibne Moin, Salahuddin Ahmed, Nazma Begum, Nurun Naher Shoma, Md Abdul Quaiyum, Abdullah H Baqui
BACKGROUND: According to the Bangladesh Demographic and Health Survey 2014, only approximately 37 percent of women deliver in a health facility. Among the eight administrative divisions of Bangladesh, the facility delivery rate is lowest in the Sylhet division (22.6 percent) where we assessed the effect of integrated supply- and demand-side interventions on the facility-based delivery rate. METHODS: Population-based cohort data of pregnant women from an ongoing maternal and newborn health improvement study being conducted in a population of ~120,000 in Sylhet district were used...
2017: PloS One
https://www.readbyqxmd.com/read/29073222/maternal-experience-of-intimate-partner-violence-and-low-birth-weight-of-children-a-hospital-based-study-in-bangladesh
#17
Jannatul Ferdos, Md Mosfequr Rahman
OBJECTIVE: Intimate partner violence (IPV) is the most prevalent form of gender-based violence worldwide. IPV either before or during pregnancy has been documented as a risk factor for the health of the mother and her unborn child. The aim of this study was to examine the relationship between maternal experience of IPV and low birth weight (LBW). STUDY DESIGN: A hospital-based survey was conducted among women in the postnatal wards of a large public hospital at Rajshahi, Bangladesh...
2017: PloS One
https://www.readbyqxmd.com/read/29072928/donor-milk-utilization-for-healthy-infants-experience-at-a-single-academic-center
#18
Sarbattama Sen, Charis Benjamin, Jennifer Riley, Abigail Heleba, Kaitlin Drouin, Katherine Gregory, Mandy Brown Belfort
BACKGROUND: Banked donor milk (BDM) has historically been used as an alternative to formula for preterm infants. Recently, BDM has been endorsed by two national organizations for use in healthy infants. We sought to quantify utilization trends and characteristics of mothers and their healthy newborns who received BDM during their postpartum stay between 2013 and 2016 at a single academic medical center. MATERIALS AND METHODS: In this observational study, we used a clinical log to identify all infants who received BDM in the well-baby nursery between July 2013 and June 2016...
October 26, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29067428/effect-of-therapeutic-hypothermia-initiated-after-6-hours-of-age-on-death-or-disability-among-newborns-with-hypoxic-ischemic-encephalopathy-a-randomized-clinical-trial
#19
RANDOMIZED CONTROLLED TRIAL
Abbot R Laptook, Seetha Shankaran, Jon E Tyson, Breda Munoz, Edward F Bell, Ronald N Goldberg, Nehal A Parikh, Namasivayam Ambalavanan, Claudia Pedroza, Athina Pappas, Abhik Das, Aasma S Chaudhary, Richard A Ehrenkranz, Angelita M Hensman, Krisa P Van Meurs, Lina F Chalak, Shannon E G Hamrick, Gregory M Sokol, Michele C Walsh, Brenda B Poindexter, Roger G Faix, Kristi L Watterberg, Ivan D Frantz, Ronnie Guillet, Uday Devaskar, William E Truog, Valerie Y Chock, Myra H Wyckoff, Elisabeth C McGowan, David P Carlton, Heidi M Harmon, Jane E Brumbaugh, C Michael Cotten, Pablo J Sánchez, Anna Maria Hibbs, Rosemary D Higgins
Importance: Hypothermia initiated at less than 6 hours after birth reduces death or disability for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our knowledge, hypothermia trials have not been performed in infants presenting after 6 hours. Objective: To estimate the probability that hypothermia initiated at 6 to 24 hours after birth reduces the risk of death or disability at 18 months among infants with hypoxic-ischemic encephalopathy...
October 24, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29057796/six-years-2011-2016-of-mandatory-nationwide-bovine-viral-diarrhea-control-in-germany-a-success-story
#20
Kerstin Wernike, Jörn Gethmann, Horst Schirrmeier, Ronald Schröder, Franz J Conraths, Martin Beer
Bovine viral diarrhea (BVD) is one of the most important infectious diseases in cattle, causing major economic losses worldwide. Therefore, control programs have been implemented in several countries. In Germany, an obligatory nationwide eradication program has been in force since 2011. Its centerpiece is the detection of animals persistently infected (PI) with BVD virus, primarily based on the testing of ear tissue samples of all newborn calves for viral genome or antigen, and their removal from the cattle population...
October 18, 2017: Pathogens
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