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https://www.readbyqxmd.com/read/29232728/-conjunction-of-orthopaedic-and-trauma-surgery-the-leipzig-model-three-years-experiences-of-o%C3%A2-%C3%A2-u%C3%A2-%C3%A2-p-at-the-university-hospital-leipzig
#1
Christoph Eckhard Heyde, Pierre Hepp, Andreas Roth, Stefan Langer, Christoph Josten
The establishment and implementation of the combined specialisation of orthopaedic and trauma surgery in daily routine was and still is a huge challenge for all stakeholders. In recent years, major efforts have been made by the professional associations, the specialty societies and all parties involved in the implementation of this project. Basically, there is no general recipe for the implementation of such a concept. For each centre or clinic, the local structural, professional and historical circumstances must be meticulously taken into account when considering implementation of this concept...
December 12, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29232723/biopsy-of-liver-target-lesions-under-contrast-enhanced-ultrasound-guidance-a-multi-center-study
#2
Giampiero Francica, Maria Franca Meloni, Ilario de Sio, Fulvia Terracciano, Eugenio Caturelli, Laura Riccardi, Paola Roselli, Maddalena Diana Iadevaia, Mariano Scaglione, Giovanni Lenna, Jason Chiang, Maurizio Pompili
Purpose To retrospectively characterize the prevalence and impact of contrast-enhanced ultrasound (CEUS) as a guidance technique for the biopsy of liver target lesions (LTLs) at six interventional ultrasound centers. Materials and Methods The six participating centers retrospectively selected all patients in whom biopsy needles were positioned in LTLs during CEUS. The prevalence of CEUS-guided biopsies at each center between 2005 and 2016, contrast agent consumption, procedure indications, diagnostic yield and complications were assessed...
December 12, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29232720/inhibitors-in-hemophilia-treatment-challenges-and-novel-options
#3
Assaf Arie Barg, Tami Livnat, Gili Kenet
No abstract text is available yet for this article.
December 12, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29232710/stabilizing-patterns-in-time-neural-network-approach
#4
Nadav Ben-Shushan, Misha Tsodyks
Recurrent and feedback networks are capable of holding dynamic memories. Nonetheless, training a network for that task is challenging. In order to do so, one should face non-linear propagation of errors in the system. Small deviations from the desired dynamics due to error or inherent noise might have a dramatic effect in the future. A method to cope with these difficulties is thus needed. In this work we focus on recurrent networks with linear activation functions and binary output unit. We characterize its ability to reproduce a temporal sequence of actions over its output unit...
December 12, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29232709/local-setting-influences-the-quantity-of-household-food-waste-in-mid-sized-south-african-towns
#5
Gamuchirai Chakona, Charlie M Shackleton
The world faces a food security challenge with approximately 868 million people undernourished and about two billion people suffering from the negative health consequences of micronutrient deficiencies. Yet, it is believed that at least 33% of food produced for human consumption is lost or wasted along the food chain. As food waste has a negative effect on food security, the present study sought to quantify household food waste along the rural-urban continuum in three South African mid-sized towns situated along an agro-ecological gradient...
2017: PloS One
https://www.readbyqxmd.com/read/29232665/the-laryngeal-mask-airway-and-its-use-in-neonatal-resuscitation-a-critical-review-of-where-we-are-in-2017-2018
#6
Satvik Chaitanya Bansal, Stefano Caoci, Eugene Dempsey, Daniele Trevisanuto, Charles Christoph Roehr
Studies using videotape recordings and respiratory function monitoring have shown that both face mask (FM) application and endotracheal tube (ETT) placement represent a challenge for resuscitators. Hence, there is a strong need for devices that can largely be used independently of individual operator training levels, in order to ensure more reliable support in time-critical situations, such as neonatal resuscitation. The laryngeal mask airway device (LMA) has evolved as a potentially very valuable tool. We conducted a systematic review of studies evaluating the use of the LMA in neonatal resuscitation...
December 13, 2017: Neonatology
https://www.readbyqxmd.com/read/29232650/internal-validation-of-two-new-retrotransposons-based-kits-innoquant%C3%A2-hy-and-innotyper%C3%A2-21-at-a-forensic-lab
#7
Cátia Martins, Paulo Miguel Ferreira, Raquel Carvalho, Sandra Cristina Costa, Carlos Farinha, Luísa Azevedo, António Amorim, Manuela Oliveira
Obtaining a genetic profile from pieces of evidence collected at a crime scene is the primary objective of forensic laboratories. New procedures, methods, kits, software or equipment must be carefully evaluated and validated before its implementation. The constant development of new methodologies for DNA testing leads to a steady process of validation, which consists of demonstrating that the technology is robust, reproducible, and reliable throughout a defined range of conditions. The present work aims to internally validate two new retrotransposon-based kits (InnoQuant® HY and InnoTyper® 21), under the working conditions of the Laboratório de Polícia Científica da Polícia Judiciária (LPC-PJ)...
November 29, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29232636/magnetite-lanthanum-hydroxide-for-phosphate-sequestration-and-recovery-from-lake-and-the-attenuation-effects-of-sediment-particles
#8
Liping Fang, Ru Liu, Ji Li, Cuihong Xu, Li-Zhi Huang, Dongsheng Wang
An effective approach for eutrophication control and phosphate recovery remains a longstanding challenge. Herein, we present a new technique for phosphate sequestration in lake and phosphate recovery using novel magnetically recoverable magnetite/lanthanum hydroxide [M-La(OH)3] hybrids that can be prepared using a simple one-pot synthesis method. Batch studies show that M-La(OH)3 exhibits a strong sorption towards phosphate with sorption capacities of up to 52.7 mg-P/g at pH 7.0 in water. A simple model indicates that the efficiency of M-La(OH)3 for phosphate sequestration in lake is significantly attenuated by 34-45% compared to that in water, due to interference from sediment particles...
December 5, 2017: Water Research
https://www.readbyqxmd.com/read/29232627/the-phenomenology-of-cell-size-control
#9
REVIEW
Kurt M Schmoller
Cells control their size through an intricate balance of cell growth, cell division, and cell death. Extensive work on unicellular model organisms revealed that cell-size-dependent cell cycle progression accounts for major aspects of cell size regulation and provided insights into the underlying molecular mechanisms. Nevertheless, elaborate live-cell imaging approaches still reveal new phenomenological observations that challenge our simplified models of size regulation and raise the question of what determines optimal cell size...
December 9, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/29232608/rapid-preparative-separation-of-monoclonal-antibody-charge-variants-using-laterally-fed-membrane-chromatography
#10
Rahul Sadavarte, Pedram Madadkar, Carlos Dm Filipe, Raja Ghosh
Monoclonal antibodies undergo various forms of chemical transformation which have been shown to cause loss in efficacy and alteration in pharmacokinetic properties of these molecules. Such modified antibody molecules are known as variants. They also display physical properties such as charge that are different from intact antibody molecules. However, the difference in charge is very subtle and separation based on it is quite challenging. Charge variants are usually separated using ion-exchange column chromatography or isoelectric focusing...
December 5, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29232600/a-retrospective-review-of-phyllodes-tumours-of-the-breast-a-single-institution-experience
#11
Vithusha Ganesh, Leah Drost, Justin Lee, Bo Angela Wan, Liying Zhang, Eileen Rakovitch, Danny Vesprini, Elzbieta Slodkowska, K Liang Zeng, Philomena Sousa, Caitlin Yee, Henry Lam, Edward Chow
BACKGROUND: Phyllodes tumours are rare and histologically diverse, posing challenges in prognosis and treatment. Due to their rarity, they have seldom been studied. PURPOSE: The purpose was to investigate clinical practices in the management of phyllodes tumours, as well as patient outcomes to contribute to the limited body of knowledge surrounding these tumours. METHODS: A retrospective review was conducted on all patients with phyllodes tumours at a single institution...
December 9, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29232557/myeloid-cell-derived-reactive-oxygen-species-induce-epithelial-mutagenesis
#12
Özge Canli, Adele M Nicolas, Jalaj Gupta, Fabian Finkelmeier, Olga Goncharova, Marina Pesic, Tobias Neumann, David Horst, Martin Löwer, Ugur Sahin, Florian R Greten
Increased oxidative stress has been suggested to initiate and promote tumorigenesis by inducing DNA damage and to suppress tumor development by triggering apoptosis and senescence. The contribution of individual cell types in the tumor microenvironment to these contrasting effects remains poorly understood. We provide evidence that during intestinal tumorigenesis, myeloid cell-derived H2O2 triggers genome-wide DNA mutations in intestinal epithelial cells to stimulate invasive growth. Moreover, increased reactive oxygen species (ROS) production in myeloid cells initiates tumor growth in various organs also in the absence of a carcinogen challenge in a paracrine manner...
December 11, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29232532/reconsideration-of-laparoscopic-kasai-operation-for-biliary-atresia
#13
Sheng-Yang Huang, Chou-Ming Yeh, Hou-Chuan Chen, Chia-Man Chou
INTRODUCTION: Minimal invasive surgery for all kinds of surgical diseases had been practiced for years. The laparoscopic Kasai operation is one of the most challenging procedures and remains controversial for treating biliary atresia (BA). PURPOSE: This work presented the initial experience of our Institute and compared the outcomes of open and laparoscopic Kasai operations for BA. MATERIALS AND METHODS: Patients 18 years old and younger, and were operated in our Institute for BA from January 2011 to August 2017, were included in this study...
December 12, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29232529/arantius-ligament-suspension-a-novel-technique-for-retraction-of-the-left-lateral-lobe-liver-during-laparoscopic-isolated-caudate-lobectomy
#14
Songshan Chai, Jianping Zhao, Yuxin Zhang, Shuai Xiang, Wanguang Zhang
BACKGROUND: Laparoscopic isolated caudate lobectomy remains a challenging procedure because of its deep location and proximity to the important vessels. We present a novel technique, Arantius ligament suspension, which could improve operative field exposure in laparoscopic isolated caudate lobectomy through retraction of the left lateral lobe liver. MATERIALS AND METHODS: The Arantius ligament suspension technique was performed in 6 selected patients during laparoscopic isolated caudate lobectomy in our center: 2 with symptomatic hepatic cavernous hemangioma and 4 with hepatocellular carcinoma (HCC)...
December 12, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29232507/interfacial-deposition-of-ru-ii-bipyridine-dicarboxylate-complexes-by-ligand-substitution-for-applications-in-water-oxidation-catalysis
#15
Degao Wang, Seth L Marquard, Ludovic Troian-Gautier, Matthew V Sheridan, Benjamin D Sherman, Ying Wang, Michael S Eberhart, Byron H Farnum, Christopher J Dares, Thomas J Meyer
Water oxidation is a critical step in artificial photosynthesis and provides the protons and electrons used in reduction reactions to make solar fuels. Significant advances have been made in the area of molecular water oxidation catalysts with a notable breakthrough in the development of Ru(II) complexes that use a planar "bda" ligand (bda is 2,2'-bipyridine-6,6'-dicarboxylate). These Ru(II)(bda) complexes show lower overpotentials for driving water oxidation making them ideal for light-driven applications with a suitable chromophore...
December 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29232506/thiolactone-chemistry-based-combinatorial-methodology-to-construct-multifunctional-polymers-for-efficacious-gene-delivery
#16
Zengshi Zha, Yongyi Hu, Jean Mukerabigwi, Weijian Chen, Yuheng Wang, Chuanxin He, Zhishen Ge
Hydrophobic segments and amino moieties in polymeric nonviral gene vectors play important roles in overcoming a cas-cade of barriers for efficient gene delivery. However, it remains a great challenge to facilely construct well-defined multi-functional polymers through optimization of the amino and hydrophobic groups. Herein, we choose thiolactone chemistry to perform the ring opening reaction of varying hydrophobic groups-modified thiolactones by various amines to generate mercapto groups for further Michael addition reaction with poly[2-(acryloyloxy)ethyl methacrylate] (PAOEMA)...
December 12, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29232501/kinetic-dearomatization-strategy-for-an-expedient-biomimetic-route-to-the-bielschowskysin-skeleton
#17
Stephane Roche, Paul Scesa, Medhi Wangpaichitr, Niramol Savaraj, Lyndon West
Bielschowskysin (1), the flagship of the furanocembranoid-derived diterpene family has attracted attention from chemists owing to its intriguing and daunting polycyclic architecture and medicinal potential against lung cancer. The high level of functionalization of 1 poses a considerable challenge to synthesis. Herein a stereoselective furan dearomatization strategy of furanocembranoids was achieved via the intermediacy of chlorohydrins. The stereochemical course of the kinetic dearomatization was established and the C-3 configuration of the resulting exo-enol ether intermediates proved to be essential to complete the late-stage transannular [2+2] photocycloaddition...
December 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29232475/front-line-therapy-of-advanced-ovarian-cancer-new-approaches
#18
J A Ledermann
Background: The 5-year survival of ovarian cancer has slowly increased but to date much of this has been due to the use of more lines of treatment rather than better first-line therapy. In this setting, there has been little improvement over the past 15 years. The introduction of new treatments to extend time to first progression and overall survival remains a key objective of clinical research. Design: The focus of research in the previous decade has been on the incorporation of anti-angiogenic therapy or dose-dense scheduling of paclitaxel (Taxol) to improve outcome...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29232469/acquired-chemotherapy-resistance-in-ovarian-cancer
#19
E L Christie, D D L Bowtell
Most women diagnosed with high-grade serous ovarian cancer (HGSC) develop recurrent disease and chemotherapy resistance, despite initially responding to treatment. The genomic characteristics of HGSC samples collected at initial surgery have been extensively studied. However, due to challenges of sample collection following treatment, much less is known about the molecular features of recurrent disease. Our recent studies have identified mechanisms of acquired resistance and biomarkers in recurrent HGSCs that could lead to improved treatment approaches...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29232463/ultrasonography-current-status-challenges-and-future-directions
#20
Byung Ihn Choi
No abstract text is available yet for this article.
November 23, 2017: Ultrasonography
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