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https://www.readbyqxmd.com/read/29677694/3s-systematic-systemic-and-systems-biology-and-toxicology
#1
Lena Smirnova, Nicole Kleinstreuer, Raffaella Corvi, Andre Levchenko, Suzanne C Fitzpatrick, Thomas Hartung
A biological system is more than the sum of its parts - it accomplishes many functions via synergy. Deconstructing the system down to the molecular mechanism level necessitates the complement of reconstructing functions on all levels, i.e., in our conceptualization of biology and its perturbations, our experimental models and computer modelling. Toxicology contains the somewhat arbitrary subclass "systemic toxicities"; however, there is no relevant toxic insult or general disease that is not systemic...
2018: ALTEX
https://www.readbyqxmd.com/read/29677671/advances-and-challenges-in-sustainable-tourism-toward-a-green-economy
#2
REVIEW
Shu-Yuan Pan, Mengyao Gao, Hyunook Kim, Kinjal J Shah, Si-Lu Pei, Pen-Chi Chiang
This paper provides an overview of the interrelationships between tourism and sustainability from a cross-disciplinary perspective. The current challenges and barriers in the tourism sustainability, such as high energy use, extensive water consumption and habitat destruction, are first reviewed. Then the key cross-disciplinary elements in sustainable tourism, including green energy, green transportation, green buildings, green infrastructure, green agriculture and smart technologies, are discussed. To overcome the challenges and barriers, a few implementation strategies on achieving sustainable tourism from the aspects of policy/regulation, institution, finance, technology and culture are proposed, along with the framework and details of a key performance indicator system...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29677664/age-induced-changes-in-the-lower-limb-muscle-activities-during-uphill-walking-at-steep-grades
#3
Sonja Th Kwee-Meier, Alexander Mertens, Sabina Jeschke
BACKGROUND: Uphill walking is particularly challenging for elderly persons. However, there is a lack of age-differentiated studies investigating the underlying differences in muscle activation when walking on sloped surfaces. These studies are needed, e.g., for planning of evacuations of large modern cruise ships with long walking distances on often inclined surfaces. METHODS: An age-differentiated, gender-balanced study with 26 young (20-30 years) and 26 elderly people (60-77 years) was therefore conducted, investigating uphill walking at 7° and at 14° contrasted to level walking on a treadmill...
April 12, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29677636/aunp-rf-sensor-an-innovative-application-of-rf-technology-for-sensing-pathogens-electrically-in-liquids-spel-within-the-food-supply-chain
#4
Leann Lerie Matta, Saranraj Karuppuswami, Premjeet Chahal, Evangelyn C Alocilja
Rapid detection techniques of pathogenic bacteria in the liquid food supply chain are of significant research interest due to their pivotal role in preventing foodborne outbreaks, and in maintaining high standards of public health and safety. Milk and dairy products are of particular interest due to their widespread consumption across the globe. In this paper, a biosensor for detecting pathogenic bacteria in milk using dextrin-capped gold nanoparticles (d-AuNP) as labels decoded at microwave frequencies is presented...
April 11, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29677595/bioherbicides-current-knowledge-on-weed-control-mechanism
#5
REVIEW
Ramalingam Radhakrishnan, Abdulaziz A Alqarawi, Elsayed Fathi Abd Allah
Weed control is a challenging event during crop cultivation. Integrated management, including the application of bioherbicides, is an emerging method for weed control in sustainable agriculture. Plant extracts, allelochemicals and some microbes are utilized as bioherbicides to control weed populations. Bioherbicides based on plants and microbes inhibit the germination and growth of weeds; however,few studies conducted in weed physiology. This review ascribes the current knowledge of the physiological changes in weeds that occur during the exposure to bioherbicides...
April 17, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29677580/effects-of-a-skill-demonstration-video-delivered-by-smartphone-on-facilitating-nursing-students-skill-competencies-and-self-confidence-a-randomized-controlled-trial-study
#6
Yeu-Hui Chuang, Fu-Chih Lai, Chia-Chi Chang, Hsu-Tien Wan
BACKGROUND: The correct and appropriate performance of nursing skills by students can ensure patient safety and care quality. However, developing appropriate teaching and learning strategies to enhance nursing students' nursing skills and knowledge are challenging tasks for nursing faculty members. Nowadays, smartphones are popular mobile devices that are used on campuses by students and could be considered a potential tool to deliver learning materials to nursing students. OBJECTIVES: This study aimed to examine the effects of a skill demonstration video delivered by smartphone on facilitating nursing students' nursing skill competency and confidence...
April 7, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29677579/factors-underlying-perceptions-of-community-care-and-other-healthcare-areas-in-first-year-baccalaureate-nursing-students-a-focus-group-study
#7
Margriet van Iersel, Corine H M Latour, Marjon van Rijn, Rien de Vos, Paul A Kirschner, Wilma J M Scholte Op Reimer
BACKGROUND: Despite the increasing labour market shortage of well-educated community nurses, few baccalaureate nursing students choose for a career in community care. Obtaining knowledge of how students perceive healthcare areas early in their education is important to take meaningful steps in counteracting any existing misconceptions with targeted curriculum redesign. OBJECTIVE: Determination of factors underlying perceptions of healthcare areas in first-year baccalaureate nursing students...
April 13, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29677574/music-colour-synaesthesia-concept-context-and-qualia
#8
REVIEW
Caroline Curwen
This review provides a commentary on coloured-hearing arising on hearing music: music-colour synaesthesia. Although traditionally explained by the hyperconnectivity theory (Ramachandran & Hubbard, 2001a) and the disinhibited feedback theory (Grossenbacher & Lovelace, 2001) as a purely perceptual phenomenon, the review of eight coloured-hearing neuroimaging studies shows that it may not be assumed that these explanations are directly translatable to music-colour synaesthesia. The concept of 'ideaesthesia' (Nikolić, 2009) and the role of conceptual and semantic inducers challenge the likelihood of a single mechanism underlying the cause of synaesthesia and argue for a move away from a purely sensory to sensory explanation...
April 17, 2018: Consciousness and Cognition
https://www.readbyqxmd.com/read/29677570/covalently-circularized-nanodiscs-challenges-and-applications
#9
REVIEW
Mahmoud L Nasr, Gerhard Wagner
Covalently circularized nanodiscs (cNDs) represent a significant advance in the durability and applicability of nanodisc technology. The new cNDs demonstrate higher size homogeneity and improved stability compared with that of non-circularized forms. Moreover, cNDs can be prepared at various defined sizes up to 80-nm diameter. The large cNDs can house much larger membrane proteins and their complexes than was previously possible with the conventional nanodiscs. In order to experience the full advantages of covalent circularization, high quality circularized scaffold protein and nanodisc samples are needed...
April 17, 2018: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/29677466/measuring-electric-fields-in-biological-matter-using-the-vibrational-stark-effect-of-nitrile-probes
#10
Joshua D Slocum, Lauren J Webb
Measurement of the electrostatic interactions that give rise to biological functions has been a longstanding challenge in biophysics. Advances in spectroscopic techniques over the past two decades have allowed for the direct measurement of electric fields in a wide variety of biological molecules and systems via the vibrational Stark effect (VSE). The frequency of the nitrile stretching oscillation has received much attention as an electric field reporter because of its sensitivity to electric fields and its occurrence in a relatively transparent region of the infrared spectrum...
April 20, 2018: Annual Review of Physical Chemistry
https://www.readbyqxmd.com/read/29677439/nanoparticle-based-photo-triggered-cancer-immunotherapy-and-its-domino-effect-in-the-tumor-microenvironment
#11
Santhosh Kalash Rajendrakumar, Saji Uthaman, Chong Su Cho, In-Kyu Park
Immune system evasion by cancer cells is one of the hallmarks of cancers, and it occurs with the support of tumor-associated immune cells (TICs) in the tumor microenvironment that increase the growth and invasiveness of tumor cells. With recent advancements in the development of novel near infrared (NIR)-responsive nanoparticles, specifically eradicating TICs or inducing an inflammatory immune response by activating killer T cells has become possible. This review will discuss the mechanisms and applications of photo-triggered immunotherapy in detail...
April 20, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29677412/gunderkids-design-of-a-clinical-care-management-program-for-parents-with-substance-abuse-and-their-newborn-children-with-a-focus-on-preventing-child-abuse
#12
Ann E Budzak-Garza, Allison L Allmon Dixson, Renee A Holzer, Kaitlin E Lillard-Pierce, Carolynn J Devine
BACKGROUND: In response to an increased need to care for babies born to mothers with substance abuse issues, we developed GunderKids, a care management program that provides integrated medical care beyond standard-of-care, well-child appointments for these socially complex families. METHODS: The program incorporates frequent visits to the pediatrician and the care team, which includes pediatric nurses, a pediatric social worker, and a child psychologist. Enrollment is voluntary...
March 2018: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29677404/hybrid-scaffolds-of-mg-alloy-mesh-reinforced-polymer-extracellular-matrix-composite-for-critical-sized-calvarial-defect-reconstruction
#13
Yingqi Chen, Sang-Ho Ye, Hideyoshi Sato, Yang Zhu, Vesselin Shanov, Tarannum Tiasha, Antonio D'Amore, Samuel Luketich, Guojiang Wan, William R Wagner
The challenge of developing scaffolds to reconstruct critical-sized calvarial defects without the addition of high levels of exogenous growth factor remains relevant. Both osteogenic regenerative efficacy as well as suitable mechanical properties for the temporary scaffold system are of importance. In this study, a Mg alloy mesh reinforced polymer/demineralized bone matrix (DBM) hybrid scaffold was designed where the hybrid scaffold was fabricated by a concurrent electrospinning/electrospraying of poly(lactic-co-glycolic) (PLGA) polymer and DBM suspended in hyaluronic acid (HA)...
April 20, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29677381/technology-innovations-for-better-fall-risk-management-in-home-care
#14
Güneş Koru, Dari Alhuwail, Onimi Jademi, Uchenna Uchidiuno, Robert J Rosati
Achieving better fall risk management is an integral component of quality home care. The current qualitative study uncovers the challenges and opportunities of home health agencies (HHAs) in achieving better fall risk management. A secondary document analysis was adopted to learn from rich contextual information in fall incident reports recorded in a HHA. Poor engagement of patients and caregivers was a contributing factor in many fall incidents. Patients often fell as a result of not understanding or accepting their physical limitations...
April 19, 2018: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/29677285/challenges-in-interpreting-the-lipid-lowering-trials-biology-vs-ecology
#15
Ann Marie Navar, Eric D Peterson
No abstract text is available yet for this article.
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29677213/ifn-%C3%AE-and-micrornas-are-important-modulators-of-the-pulmonary-innate-immune-response-against-influenza-a-h1n2-infection-in-pigs
#16
Louise Brogaard, Lars E Larsen, Peter M H Heegaard, Christian Anthon, Jan Gorodkin, Ralf Dürrwald, Kerstin Skovgaard
The innate immune system is paramount in the response to and clearance of influenza A virus (IAV) infection in non-immune individuals. Known factors include type I and III interferons and antiviral pathogen recognition receptors, and the cascades of antiviral and pro- and anti-inflammatory gene expression they induce. MicroRNAs (miRNAs) are increasingly recognized to participate in post-transcriptional modulation of these responses, but the temporal dynamics of how these players of the antiviral innate immune response collaborate to combat infection remain poorly characterized...
2018: PloS One
https://www.readbyqxmd.com/read/29677206/synergistic-interaction-between-a-pde5-inhibitor-sildenafil-and-a-new-adenosine-a2a-receptor-agonist-lassbio-1359-improves-pulmonary-hypertension-in-rats
#17
Allan K Alencar, Fábio I Carvalho, Ananssa M Silva, Sabrina T Martinez, Jorge A Calasans-Maia, Carlos M Fraga, Eliezer J Barreiro, Gisele Zapata-Sudo, Roberto T Sudo
INTRODUCTION: Pulmonary hypertension (PH) is characterized by enhanced pulmonary vascular resistance, which causes right ventricle (RV) pressure overload and results in right sided heart failure and death. This work investigated the effectiveness of a combined therapy with PDE5 inhibitor (PDE5i) and a new adenosine A2A receptor (A2AR) agonist in mitigating monocrotaline (MCT) induced PH in rats. METHODS: An in vitro isobolographic analysis was performed to identify possible synergistic relaxation effect between sildenafil and LASSBio 1359 in rat pulmonary arteries (PAs)...
2018: PloS One
https://www.readbyqxmd.com/read/29677191/type-2-diabetic-aldehyde-dehydrogenase-2-mutant-mice-aldh-2-2-exhibiting-heart-failure-with-preserved-ejection-fraction-phenotype-can-be-determined-by-exercise-stress-echocardiography
#18
Guodong Pan, Srikar Munukutla, Ananya Kar, Joseph Gardinier, Rajarajan A Thandavarayan, Suresh Selvaraj Palaniyandi
E487K point mutation of aldehyde dehydrogenase (ALDH) 2 (ALDH2*2) in East Asians intrinsically lowers ALDH2 activity. ALDH2*2 is associated with diabetic cardiomyopathy. Diabetic patients exhibit heart failure of preserved ejection fraction (HFpEF) i.e. while the systolic heart function is preserved in them, they may exhibit diastolic dysfunction, implying a jeopardized myocardial health. Currently, it is challenging to detect cardiac functional deterioration in diabetic mice. Stress echocardiography (echo) in the clinical set-up is a procedure used to measure cardiac reserve and impaired cardiac function in coronary artery diseases...
2018: PloS One
https://www.readbyqxmd.com/read/29677173/what-does-this-mutation-mean-the-tools-and-pitfalls-of-variant-interpretation-in-lymphoid-malignancies
#19
REVIEW
Guillermin Yann, Lopez Jonathan, Chabane Kaddour, Hayette Sandrine, Bardel Claire, Salles Gilles, Sujobert Pierre, Huet Sarah
High throughput sequencing (HTS) is increasingly important in determining cancer diagnoses, with subsequent prognostic and therapeutic implications. The biology of cancer is becoming increasingly deciphered and it is clear that therapy needs to be individually tailored. Whilst translational research plays an important role in lymphoid malignancies, few guidelines exist to guide biologists and routine laboratories through this constantly evolving field. In this article, we review the challenges of interpreting HTS in lymphoid malignancies and provide a toolkit to interpret single nucleotide variants obtained from HTS...
April 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29677100/from-community-to-meta-community-mental-health-care
#20
REVIEW
Nick Bouras, George Ikkos, Thomas Craig
Since the 1960s, we have witnessed the development and growth of community mental health care that continues to dominate mental health policy and practice. Several high-income countries have implemented community mental health care programmes but for many others, including mostly low- and middle-income countries, it remains an aspiration. Although community mental health care has been positive for many service users, it has also had severe shortcomings. Expectations that it would lead to fuller social integration have not been fulfilled and many service users remain secluded in sheltered or custodial environments with limited social contacts and no prospect of work...
April 20, 2018: International Journal of Environmental Research and Public Health
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