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https://www.readbyqxmd.com/read/28103651/addressing-the-challenges-in-forensic-drug-chemistry
#1
EDITORIAL
Simon D Brandt, Pierce V Kavanagh
No abstract text is available yet for this article.
January 19, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28103613/tissue-based-next-generation-sequencing-application-in-a-universal-healthcare-system
#2
REVIEW
Seán O Hynes, Brendan Pang, Jacqueline A James, Perry Maxwell, Manuel Salto-Tellez
In the context of solid tumours, the evolution of cancer therapies to more targeted and nuanced approaches has led to the impetus for personalised medicine. The targets for these therapies are largely based on the driving genetic mutations of the tumours. To track these multiple driving mutations the use of next generation sequencing (NGS) coupled with a morphomolecular approach to tumours, has the potential to deliver on the promises of personalised medicine. A review of NGS and its application in a universal healthcare (UHC) setting is undertaken as the technology has a wide appeal and utility in diagnostic, clinical trial and research paradigms...
January 19, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28103588/quantifying-kinetics-from-time-series-of-single-molecule-fret-efficiency-histograms
#3
Stephan Benke, Daniel Nettels, Hagen Hofmann, Benjamin Schuler
Single-molecule fluorescence spectroscopy is a powerful approach for probing biomolecular structure and dynamics, including protein folding. For the investigation of nonequilibrium kinetics, F��rster resonance energy transfer (FRET) in combination with confocal multiparameter detection has proven particularly versatile, owing to the large number of observables and the broad range of accessible timescales, especially in combination with rapid microfluidic mixing. However, a comprehensive kinetic analysis of the resulting time series of transfer efficiency histograms and complementary observables can be challenging owing to the complexity of the data...
January 19, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28103561/statistical-shape-modeling-of-the-left-ventricle-myocardial-infarct-classification-challenge
#4
Avan Suinesiaputra, Pierre Ablin, Xenia Alba, Martino Alessandrini, Jack Allen, W Bai, Serkan Cimen, Peter Claes, Brett R Cowan, Jan D'hooge, Nicolas Duchateau, Jan Ehrhardt, Alejandro F Frangi, Ali Gooya, Vicente Grau, Karim Lekadir, Allen Lu, Anirban Mukhopadhyay, Ilkay Oksuz, Xavier Pennec, Marco Pereanez, Catarina Pinto, Paolo Piras, Marc-Michel Rohe, Daniel Rueckert, Maxime Sermesant, Kaleem Siddiqi, Mahdi Tabassian, Luciano Teresi, Sotirios A Tsaftaris, Matthias Wilms, Alistair A Young, Xingyu Zhang, Pau Medrano-Gracia
Statistical shape modeling is a powerful tool for visualizing and quantifying geometric and functional patterns of the heart. After myocardial infarction (MI), the left ventricle typically remodels in response to physiological challenges. Several methods have been proposed in the literature to describe statistical shape changes. Which method best characterizes left ventricular remodeling after MI is an open research question. A better descriptor of remodeling is expected to provide a more accurate evaluation of disease status in MI patients...
January 17, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28103557/data-dependent-label-distribution-learning-for-age-estimation
#5
Zhouzhou He, Xi Li, Zhongfei Zhang, Fei Wu, Xin Geng, Yaqing Zhang, Ming-Hsuan Yang, Yueting Zhuang
As an important and challenging problem in computer vision, face age estimation is typically cast as a classification or regression problem over a set of face samples with respect to several ordinal age labels, which have intrinsically cross-age correlations across adjacent age dimensions. As a result, such correlations usually lead to the age label ambiguities of the face samples. Namely, each face sample is associated with a latent label distribution that encodes the cross-age correlation information on label ambiguities...
January 18, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28103555/robust-head-pose-estimation-based-on-partially-latent-mixture-of-linear-regressions
#6
Vincent Drouard, Radu Horaud, Antoine Deleforge, Sileye Ba, Georgios Evangelidis
Head-pose estimation has many applications, such as social event analysis, human-robot and human-computer interaction, driving assistance, and so forth. Head-pose estimation is challenging because it must cope with changing illumination conditions, variabilities in face orientation and in appearance, partial occlusions of facial landmarks, as well as bounding-box-to- face alignment errors. We propose tu use a mixture of linear regressions with partially-latent output. This regression method learns to map high-dimensional feature vectors (extracted from bounding boxes of faces) onto the joint space of head-pose angles and bounding-box shifts, such that they are robustly predicted in the presence of unobservable phenomena...
January 16, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28103546/quantifying-net-synergy-redundancy-of-spontaneous-variability-regulation-via-predictability-and-transfer-entropy-decomposition-frameworks
#7
Alberto Porta, Vlasta Bari, Beatrice De Maria, Anielle C M Takahashi, Stefano Guzzetti, Riccardo Colombo, Aparecida M Catai, Ferdinando Raimondi, Luca Faes
OBJECTIVE: Indexes assessing the balance between redundancy and synergy were hypothesized to be helpful in characterizing cardiovascular control from spontaneous beat-to-beat variations of heart period (HP), systolic arterial pressure (SAP) and respiration (R). METHODS: Net redundancy/synergy indexes were derived according to predictability and transfer entropy decomposition strategies via a multivariate linear regression approach. Indexes were tested in two protocols inducing modifications of the cardiovascular regulation via baroreflex loading/unloading (i...
January 17, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28103542/interactive-exploration-of-3d-scanned-baggage
#8
Michael Traore, Christophe Hurter
An interactive visualization system can support volumetric data exploration in airport security screenings by addressing the challenges unique to the baggage inspection. The proposed system includes a set of interaction techniques that combine the direct manipulation of voxels and their interactive visualization. The system's final tools and GUI design incorporate feedback from airport personnel and were validated by real-world users in terms of effectiveness and ease of use.
January 2017: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/28103539/algorithm-animation-with-galant
#9
Matthias F Stallmann
Although surveys suggest positive student attitudes toward the use of algorithm animations, it is not clear that they improve learning outcomes. The Graph Algorithm Animation Tool, or Galant, challenges and motivates students to engage more deeply with algorithm concepts, without distracting them with programming language details or GUIs. Even though Galant is specifically designed for graph algorithms, it has also been used to animate other algorithms, most notably sorting algorithms.
January 2017: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/28103500/thoracoscopic-surgery-in-the-prone-position-for-esophageal-cancer-in-patients-with-situs-inversus-totalis-a-report-of-two-cases
#10
Toru Nakano, Takashi Kamei, Yu Onodera, Naoto Ujiie, Noriaki Ohuchi
INTRODUCTION: Situs inversus totalis (SIT) is a rare congenital condition characterized by a complete transposition of thoracic and abdominal organs. Here, we present two successful cases of left thoracoscopic esophagectomy in the prone position for SIT-associated esophageal cancer. PRESENTATION OF CASE: Our first case was of an 82-year-old man who underwent a left thoracoscopic esophagectomy in the prone position, followed by hand-assisted laparoscopic gastric mobilization...
January 6, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28103450/paper-based-analytical-devices-for-clinical-diagnosis-recent-advances-in-the-fabrication-techniques-and-sensing-mechanisms
#11
Mazhar Sher, Rachel Zhuang, Utkan Demirci, Waseem Asghar
There is a significant interest in developing inexpensive portable biosensing platforms for various applications including disease diagnostics, environmental monitoring, food safety, and water testing at the point-of-care (POC) settings. Current diagnostic assays available in the developed world require sophisticated laboratory infrastructure and expensive reagents. Hence, they are not suitable for resource-constrained settings with limited financial resources, basic health infrastructure, and few trained technicians...
January 19, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28103319/an-hsv-2-trivalent-vaccine-is-immunogenic-in-rhesus-macaques-and-highly-efficacious-in-guinea-pigs
#12
Sita Awasthi, Lauren M Hook, Carolyn E Shaw, Bapi Pahar, Jacob A Stagray, David Liu, Ronald S Veazey, Harvey M Friedman
A genital herpes vaccine is urgently needed to prevent pain and suffering, reduce the incidence of neonatal herpes, and decrease the risk of HIV acquisition and transmission that accompanies genital infection. We evaluated a trivalent HSV-2 subunit antigen vaccine administered with CpG and alum in rhesus macaques and guinea pigs. The vaccine contains glycoproteins C, D and E (gC2, gD2, gE2) to block virus entry by gD2 and immune evasion by gC2 and gE2. In rhesus macaques, the trivalent vaccine induced plasma and mucosa neutralizing antibodies, antibodies that block gC2 and gE2 immune evasion activities, and stimulated CD4 T cell responses...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28103277/protection-elicited-by-nasal-immunization-with-recombinant-pneumococcal-surface-protein-a-rpspa-adjuvanted-with-whole-cell-pertussis-vaccine-wp-against-co-colonization-of-mice-with-streptococcus-pneumoniae
#13
Rafaella O Tostes, Tasson C Rodrigues, Josefa B da Silva, Alessandra S Schanoski, Maria Leonor S Oliveira, Eliane N Miyaji
A promising alternative vaccine candidate to reduce the burden of pneumococcal diseases is the protein antigen PspA (Pneumococcal surface protein A). Since concomitant colonization with two or more pneumococcal strains is very common in children, we aimed to determine if immunization with PspA would be able to control co-colonization. We evaluated nasal immunization with recombinant PspA (rPspA) in a model of co-colonization with two strains expressing different PspAs. Mice were immunized intranasally with rPspAs from clades 1 to 4 (rPspA1, rPspA2, rPspA3 or rPspA4) using whole-cell pertussis vaccine (wP) as adjuvant...
2017: PloS One
https://www.readbyqxmd.com/read/28103269/wildlife-population-dynamics-in-human-dominated-landscapes-under-community-based-conservation-the-example-of-nakuru-wildlife-conservancy-kenya
#14
Joseph O Ogutu, Bernard Kuloba, Hans-Peter Piepho, Erustus Kanga
Wildlife conservation is facing numerous and mounting challenges on private and communal lands in Africa, including in Kenya. We analyze the population dynamics of 44 common wildlife species in relation to rainfall variation in the Nakuru Wildlife Conservancy (NWC), located in the Nakuru-Naivasha region of Kenya, based on ground total counts carried out twice each year from March 1996 to May 2015. Rainfall in the region was quasi-periodic with cycle periods dependent on the rainfall component and varying from 2...
2017: PloS One
https://www.readbyqxmd.com/read/28103239/identifying-t-cell-receptors-from-high-throughput-sequencing-dealing-with-promiscuity-in-tcr%C3%AE-and-tcr%C3%AE-pairing
#15
Edward S Lee, Paul G Thomas, Jeff E Mold, Andrew J Yates
Characterisation of the T cell receptors (TCR) involved in immune responses is important for the design of vaccines and immunotherapies for cancer and autoimmune disease. The specificity of the interaction between the TCR heterodimer and its peptide-MHC ligand derives largely from the juxtaposed hypervariable CDR3 regions on the TCRα and TCRβ chains, and obtaining the paired sequences of these regions is a standard for functionally defining the TCR. A brute force approach to identifying the TCRs in a population of T cells is to use high-throughput single-cell sequencing, but currently this process remains costly and risks missing small clones...
January 19, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28103236/impact-of-cd4-t-cell-responses-on-clinical-outcome-following-oral-administration-of-wild-type-enterotoxigenic-escherichia-coli-in-humans
#16
Monica A McArthur, Wilbur H Chen, Laurence Magder, Myron M Levine, Marcelo B Sztein
Enterotoxigenic Escherichia coli (ETEC) is a non-invasive enteric pathogen of considerable public health importance, being one of the most common attributable causes of diarrheal illness in infants and young children in developing countries and the most common cause of traveler's diarrhea. To enhance study-to-study consistency of our experimental challenge model of ETEC in volunteers, and to allow concomitant multi-site trials to evaluate anti-ETEC immunoprophylactic products, hundreds of vials, each containing a standardized inoculum of virulent wild-type (wt) ETEC strain H10407 (serotype O78:H11 expressing colonization factor antigen I and heat-labile and heat-stable enterotoxins), were prepared under current Good Manufacturing Practices (cGMP) and frozen...
January 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28103193/comprehensive-use-of-curvature-for-robust-and-accurate-online-surface-reconstruction
#17
Damien Lefloch, Markus Kluge, Hamed Sarbolandi, Tim Weyrich, Andreas Kolb
Interactive real-time scene acquisition from hand-held depth cameras has recently developed much momentum, enabling applications in ad-hoc object acquisition, augmented reality and other fields. A key challenge to online reconstruction remains error accumulation in the reconstructed camera trajectory, due to drift-inducing instabilities in the range scan alignments of the underlying iterative-closest-point (ICP) algorithm. Various strategies have been proposed to mitigate that drift, including SIFT-based pre-alignment, color-based weighting of ICP pairs, stronger weighting of edge features, and so on...
January 5, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28103192/audio-visual-speaker-diarization-based-on-spatiotemporal-bayesian-fusion
#18
Israel Gebru, Sileye Ba, Xiaofei Li, Radu Horaud
Speaker diarization consists of assigning speech signals to people engaged in a dialogue. An audio-visual spatiotemporal diarization model is proposed. The model is well suited for challenging scenarios that consist of several participants engaged in multi-party interaction while they move around and turn their heads towards the other participants rather than facing the cameras and the microphones. Multiple-person visual tracking is combined with multiple speech-source localization in order to tackle the speech-to-person association problem...
January 5, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28103189/dynamic-programming-for-instance-annotation-in-multi-instance-multi-label-learning
#19
Anh Pham, Raviv Raich, Xiaoli Fern
Labeling data for classification requires significant human effort. To reduce labeling cost, instead of labeling every instance, a group of instances (bag) is labeled by a single bag label. Computer algorithms are then used to infer the label for each instance in a bag, a process referred to as instance annotation. This task is challenging due to the ambiguity regarding the instance labels. We propose a discriminative probabilistic model for the instance annotation problem and introduce an expectation maximization framework for inference, based on the maximum likelihood approach...
January 5, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28103154/facilitator-training-program-the-universit%C3%A3-laval-interprofessional-initiative
#20
Élise Milot, Anne-Claire Museux, Emmanuelle Careau
A facilitator training program (FTP) for interprofessional learning (IPL) facilitators has been developed at Université Laval. This article describes the impacts of this program as perceived by the 22 IPL facilitators involved and outlines recommendations. Two qualitative data collection strategies were used to document the facilitators' pedagogical needs and views of the program's impacts. Results suggest that the FTP's pedagogical approach was effective. The IPL facilitators became more aware of their challenges and identified concrete strategies to use...
January 19, 2017: Social Work in Health Care
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