Darrin J Lee, Luka Milosevic, Robert Gramer, Sanskriti Sasikumar, Tameem M Al-Ozzi, Philippe De Vloo, Robert F Dallapiazza, Gavin J B Elias, Melanie Cohn, Suneil K Kalia, William D Hutchison, Alfonso Fasano, Andres M Lozano
OBJECTIVENeuronal loss within the cholinergic nucleus basalis of Meynert (nbM) correlates with cognitive decline in dementing disorders such as Alzheimer's disease and Parkinson's disease (PD). In nonhuman primates, the nbM firing pattern (5-40 Hz) has also been correlated with working memory and sustained attention. In this study, authors performed microelectrode recordings of the globus pallidus pars interna (GPi) and the nbM immediately prior to the implantation of bilateral deep brain stimulation (DBS) electrodes in PD patients to treat motor symptoms and cognitive impairment, respectively...
February 22, 2019: Journal of Neurosurgery